PMID
int64 35.7M
36.4M
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36,289,297
|
associ social disengag health status caus mortal among communiti dwell older adult evid otassha studi studi examin impact disengag health status mortal among communiti dwell older adult japan disengag societi oper defin drop longitudin survey follow mail survey conduct among respond n baselin mail survey step step follow survey fls includ simplifi mail postcard home visit survey sent particip respond disengag level defin accord respons fls zero mail survey low simplifi mail survey middl postcard survey high home visit survey highest non respond home visit survey adjust health status baselin proport respond self rate healthi fls signific higher high level zero level group proport respond report week less frequenc go outdoor fls signific higher low middl high level group zero level group mortal rate signific higher high highest level zero level group higher disengag level increas risk lower health status mortal suggest urgent need prevent societ disengag among older adult
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D057187;D006304
|
T056;T080
|
36,289,296
|
direct current stimul modul gene express isol astrocyt implic glia mediat plastic applic transcrani direct current stimul tdcs across brain diseas cognit divers reli chang brain function outlast stimul cellular mechan dcs lead brain plastic studi role astrocyt remain unaddress previous predict tdcs current concentr across blood brain barrier amplifi exposur endotheli cell ec form blood vessel astrocyt wrap around object studi investig effect tdcs gene express astrocyt ec dcs min appli monolay mous brain ec human astrocyt gene express set neuroact gene measur use rt qpcr express assess immedi h dcs previous show dcs produc electroosmot flow fluid shear stress known influenc ec astrocyt function compar three intervent pressur driven flow across monolay alon pressur driven flow plus dcs dcs alon flow block show dcs direct modul gene express astrocyt notabl fos bdnf independ synergist pressur driven flow gene express ec pressur driven flow activ gene express evid contribut dcs ec dcs alon produc mix effect includ upregul fgf downregul ntf propos new adjunct mechan tdcs base glial medit plastic
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D001253;D065908
|
T061;T025
|
36,289,293
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spatial scale pollen plant divers relationship landscap contrast divers pattern mitig effect global chang biodivers requir understand past main proxi plant divers fossil pollen record complex relationship surround veget unknown spatial scale explor use modern pollen spectra speci rich speci poor region temper central europ also consid bias effect tree use site forest open habitat region pollen sampl collect moss polster site plant speci record along two km transect site found signific posit correl pollen plant rich alpha divers complet dataset subset open habitat pollen rich forest dataset signific relat florist data due canopi intercept pollen rather pollen product varianc beta divers six pollen florist dataset strong correl sourc area pollen rich determin number speci appear increas distanc aggreg inform divers individu patch within landscap mosaic composit similar result valid pollen reconstruct tool plant divers past
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D065928;D044822
|
T070;T080
|
36,289,292
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simul machin learn enabl learn health system risk predict use synthet patient data enabl machin learn ml learn health system lhs hold promis improv effect healthcar deliveri patient one major barrier lhs research develop lack access ehr patient data overcom challeng studi demonstr feasibl develop simul ml enabl lhs use synthet patient data ml enabl lhs initi use dataset synthet synthea patient risk predict xgboost base model lung cancer addit dataset patient generat ad previous updat dataset sequenti simul addit new patient result dataset patient new xgboost model built instanc perform improv data size increas attain recal auc area curv patient dataset effect new ml enabl lhs process verifi implement xgboost model stroke risk predict synthea patient popul make ml code synthet patient data public avail test train first synthet lhs process pave way research start develop lhs real patient data
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D000080891;D008175
|
T058;T191
|
36,289,291
|
low glutam diet improv work memori contribut alter bold respons function connect within work memori network gulf war ill gulf war ill chronic multi symptom disord sever cognit impair may relat glutam excitotox central nervous system dysfunct low glutam diet propos comprehens intervent gulf war ill examin effect low glutam diet verbal work memori use fmri n back task accuraci whole brain blood oxygen level depend bold respons task base function connect assess baselin month diet n multi voxel pattern analysi identifi region whole brain bold pattern differ diet use seed subsequ seed voxel function connect analys verbal work memori accuraci improv diet p whole brain bold signal chang observ reveal lower activ within region frontopariet network default mode network low glutam diet multi voxel pattern analysi result cluster compris part frontopariet network cluster ventral attent network cluster seed voxel analys identifi signific function connect chang post diet cluster peak p cluster fdr p relat baselin cluster decreas function connect region ventral attent somatomotor network cluster also increas function connect region default mode frontopariet network find suggest among veteran gulf war ill low glutam diet improv verbal work memori accuraci alter bold respons alter function connect within two network central work memori
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D008570;D018923
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T047;T041
|
36,289,289
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transcriptom analysi predict metabol state stress induc viabl non cultur bacillus subtili cell mani bacteria adapt physiolog enter viabl non cultur state surviv prolong exposur advers environment condit vbnc cell maintain activ metabol membran integr gene transcript howev lose abil form coloni convent cultur media thus standard coloni count method detect aliv dormant cell gram posit bacterium bacillus subtili found enter vbnc state pre expos osmot stress treat lethal dose kanamycin cell reduc metabol activ ceas growth divis becam kanamycin toler interest despit activ metabol major kanamycin toler cell could reviv lb agar studi use robust rna seq techniqu elucid differ transcript profil b subtili vbnc cell compar analysi differ express gene operon perform studi indic high similar transcript respons vbnc kanamycin sensit cell antibiot treatment moreov work reveal vbnc cell strong upregul gene involv prolin uptak catabol suggest putat role prolin nutrient vbnc cell
|
D015964;D001412
|
T045;T007
|
36,289,288
|
combin ulinastatin somatostatin reduc complic rate acut pancreat systemat review meta analysi random control trial current specif pharmaceut agent treat acut pancreat ap somatostatin analogu use prevent autolysi pancrea ap howev effect confirm investig aim examin efficaci ulinastatin proteas inhibitor combin somatostatin analogu treatment ap conduct systemat databas search databas identifi random control trial efficaci ulinastatin combin somatostatin analogu compar somatostatin analogu alon patient ap sinc patient popul analys paper slight differ use random effect model pool odd ratio mean differ md correspond confid interv ci total articl compris patient includ meta analysi combin therapi signific reduc complic rate acut respiratori distress syndrom acut kidney injuri multipl organ dysfunct symptom reliev threefold combin therapi compar somatostatin alon combin therapi signific shorten length hospit stay decreas mortal statist signific
|
D010195
|
T047;T046
|
36,289,287
|
cftr delet mous epitheli immun cell differenti influenc intestin microbiota cystic fibrosi cf life threaten genet disord caus mutat cf transmembran conduct regul gene cftr encod cftr camp activ chlorid bicarbon channel clinic cf lung diseas domin adult patient popul howev gastrointestin ill claim earli morbid mortal manifest intestin dysbiosi inflamm obstruct cf wide accept diseas epitheli dysfunct unknown whether cftr loss function immun cell contribut clinic outcom use cftr genet knockout bone marrow transplant mous model perform rrna gene sequenc intestin microb show cftr delet epitheli immun cell collect influenc intestin microbiota howev immun defect major factor determin dysbiosi small intestin epitheli defect larg influenc larg intestin find revis current concept suggest cf epitheli defect immun defect play differenti role cf intestin diseas
|
D000069196;D003550
|
T047;T007;T001
|
36,289,286
|
assess impact covid mass test south tyrol use semi parametr growth model mass antigen test propos possibl cost effect tool contain covid pandem test impact voluntari mass test campaign implement italian region south tyrol spread virus follow month use innov empir approach emb semi parametr growth model covid transmiss dynam allow vari across region impact implement mass test campaign synthet control framework creat appropri control group italian region result suggest mass test campaign use instrument mitig pandem
|
D000086382;D001686
|
T047;T070;T067;T038
|
36,289,285
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pseudovirus base platform measur neutral antibodi mexico use sar cov proof concept gold standard method evalu function antivir immun respons titer neutral antibodi nab viral pathogen histor perform use vitro assay virus mediat infect requir bsl facil insuffici latin american countri includ mexico scant inform obtain local viral pathogen nab use function assay altern solut use bsl assay live virus use bsl safe assay non replic pseudovirus pseudovir particl engin display select pathogen entri protein surfac deliv report gene target cell upon transduct comprehens describ first develop bsl safe nab measur function assay mexico base product pseudotyp lentivir particl proof concept assay base nanoluc luciferas mediat luminesc measur target cell transduc sar cov spike pseudotyp lentivir particl appli optim assay bsl facil measur nab serum sampl evidenc assay sensit specif accuraci overal first report bsl safe pseudovirus base function assay develop mexico measur nab cornerston methodolog necessari measur nab function assay limit resourc set
|
D057134;D000086382
|
T129;T047;T116;T067
|
36,289,284
|
real world data prognost signific monocytopenia myelodysplast syndrom monocytopenia common find patient myelodysplast syndrom mds although monocyt may exhibit prognost signific mds due role innat immun incorpor prognost score system mds studi analyz nation registri data adult mds monocytopenia present patient correl presenc excess blast higher revis intern prognost score system categori univari analysi show monocytopenia prognost lower overal surviv os versus month p retain prognost signific multivari model compris anemia neutropenia thrombocytopenia hazard ratio hr os p moreov prognost lower leukemia free surviv lfs univari analysi multivari model compris cytopenia bone marrow blast cytogenet risk hr lfs p find regard os lfr exclus pronounc lower risk patient respect moreov monocytopenia could divid low intermedi risk group ipss r prognost distinct subgroup result redefin prognost role monocyt mds set basi studi valid result expand knowledg prognost signific monocytopenia mds
|
D009190;D013921;D009503
|
T047;T046;T191
|
36,289,282
|
preval la mrsa pigsti analysi factor influenc de colon process profession pig husbandri often associ less high load la mrsa possibl risk factor la mrsa colon pig herd alreadi identifi studi suggest hous condit may affect la mrsa preval europ pig kept varieti condit aim studi identifi husbandri hous condit factor affect colon la mrsa pig farm select assign three categori accord hous condit convent altern organ anim surfac sampl taken examin presenc la mrsa begin end one fatten period per farm altogeth signific p decreas colon la mrsa begin end fatten period pig surfac observ altern farm show higher dynam colon organ farm almost colon found influenc hous condit factor determin la mrsa status end fatten period number pig build la mrsa status begin fatten period materi floor straw bed strict black white separ antibiot treatment fatten period pig farm general knowledg measur reduc colon la mrsa would import
|
D055624;D013203;D013553
|
T047;T007
|
36,289,281
|
map human diseas associ enzym reactom allow character diseas group interact accord databas omim humsavar clinvar monarch human enzym present associ genet diseas rare orphanet code mondo ontolog initi allow standard diseas name specif code make possibl comput associ gene variant diseas effect biolog process tackl problem biolog process enzym affect protein variant diseas associ adopt reactom describ human biolog process map diseas associ enzym reactom pathway establish reactom diseas associ allow novel categor human monogen polygen diseas base reactom pathway reaction analysi aim dissect complex human genet diseas univers highlight possibl link within diseas reactom pathway novel map help understand biochemicalmolecular biolog diseas allow direct glimps present knowledg molecul involv use complet overview diseas molecular mechan plan futur investig data collect dar databas free search avail https darbiocompuniboit
|
D001686
|
T070;T038
|
36,289,280
|
new schiff base ligand novel cr iii mn ii co ii ni ii cu ii zn ii complex spectral investig biolog applic semiconduct properti new schiff base ligand deriv antivir valacyclovir novel cr iii mn ii co ii ni ii cu ii zn ii complex synthes use varieti analyt spectroscop techniqu type bond ligand metal ion recent form complex clarifi schiff base ligand act bident coordin metal ion azomethin n phenol center mono deproton form except zn ii complex display tetrahedr geometri complex display octahedr geometri tga find support stabil decomposit properti metal complex entir distinct one anoth thermogram show decomposit investig metal complex c three four five step indic high thermal stabil complex accord xrd pattern particl complex locat nanoscal moreov sampl analyz tem imag show uniform homogen surfac morpholog biolog activ reveal high effici screen complex antibacteri antitumor agent antimicrobi activ ligand complex examin varieti pathogen bacteria fungi includ escherichia coli staphylococcus aureus candida albican data obtain reveal metal ion complex enhanc antimicrobi activ compar free ligand high effici toward aureus e coli c albican appear cu ii complex ni ii complex ni ii complex respect antitumor activ ligand complex test hepatocellular carcinoma cell line hepg cell residu produc heat cu ii complex c h exhibit strong inhibit hepg cell growth result dna cleavag investig demonstr abil investig cu ii complex degrad dna dock find show strong interact ligand examin cu ii complex reveal abil cleavag dna potent inhibitori effect tumor cell electr conduct studi confirm ligand investig complex semiconduct properti
|
D056831;D000970
|
T104;T121;T109
|
36,289,279
|
comparison genet suscept lung adenocarcinoma squamous cell carcinoma japanes patient use novel panel cancer relat drug metabol enzym gene differ genet suscept lung adenocarcinoma squamous cell carcinoma remain unclear develop custom target gene sequenc panel effici sensit identif germlin variant includ whole gene delet type cancer relat drug metabol enzym gene lung adenocarcinoma squamous cell carcinoma minor allel frequenc variant confirm clinic signific japanes popul differ signific normal particip list public databas genotyp analysi compar lung adenocarcinoma n squamous cell carcinoma n indic variant dpyd rs fisher exact test p rs p aldh rs p associ increas risk squamous cell carcinoma compar adenocarcinoma convers whole gene delet cypa associ adenocarcinoma squamous cell carcinoma notabl whole gene delet cypa confirm patient lung adenocarcinoma patient squamous cell carcinoma patient whole gene delet cypa femal non smoker discoveri whole gene delet cypa patient lung adenocarcinoma may import role clinic practic advanc understand cypa germlin variant associ carcinogenesi suscept lung adenocarcinoma
|
D000230;D000077192;D002294;D008175
|
T191
|
36,289,278
|
pattern microbi resist bloodstream infect hemodialysi patient cross section studi palestin bloodstream infect bsis promin caus death hospit among hemodialysi hd patient emerg multidrug resist organ mdro make manag infect challeng studi describ clinic characterist microbi profil antibiot resist pattern patient bsis retrospect cross section studi conduct najah nation univers hospit januari decemb clinic demograph data regard bsis collect hospit inform system data regard bacteri isol antimicrobi resist bsis collect microbiolog lab data enter analyz use version statist packag social scienc program ibm spss bsis occur studi period rate infect per patient month patient hd median durat day alreadi bsi studi period microorgan isol gram posit gram negat among gram posit isol coagulas negat staphylococci con predomin gram negat isol frequent stenotrophomona maltophilia escherichia coli five posit cultur among latter two extend spectrum beta lactamas produc esbl frequent use empir antibiot combin vancomycin gentamicin follow vancomycin alon regard gram posit isol vancomycin frequent use effect antibiot cultur wherea gram negat bacteria found gentamicin mdros defin resist least one agent three antimicrobi categori isol found mdro gram posit bacteria gram negat bacteria compar patient accord type vascular access infect mdro found among patient central venous cathet cvcs howev statist signific relationship found type vascular access infect mdro p mdro caus remark high proport bsis palestinian patient result studi support empir use vancomycin gentamicin treat infect vital health care provid prevent infect via institut adher infect control polici hemodialysi center provid proper antibiot therapi limit use durat necessari avoid breed resist
|
D016470;D018805
|
T047;T046
|
36,289,277
|
multilay perceptron base predict stroke mimic prehospit triag identif stroke mimic sms patient stroke could lead delay diagnosi wast medic resourc multilay perceptron mlp prove accur tool clinic applic howev mlp nt appli patient suspect stroke onset within h aim develop mlp model predict sm patient retrospect review data patient prehospit diagnosi suspect stroke juli june sms confirm hospit includ demograph inform clinic manifest medic histori systol diastol pressur admiss first cohort random divid train set extern test set least absolut shrinkag select oper lasso method use featur select mlp model train base select item evalu perform model use ten fold cross valid method final use extern test set compar mlp model fab score system fab telestrok mimic score tm score use receiv oper characterist roc curv total patient includ classifi sms ten fold cross valid mean area roc curv auc train set valid set respect extern test set auc mlp model signific higher fab vs p tm score vs p mlp model signific better perform predict sms fab tm score
|
D014218;D020521
|
T061;T047
|
36,289,276
|
advanc setup safe breath sampl patient monitor high infecti condit clinic environ proxim matrix breath offer immedi metabol outlook respiratori infect howev high viral load exhal impos higher transmiss risk need improv method safe repeat analysi advanc state art method real time offlin mass spectrometri base analysi exhal volatil organ compound voc sar cov andor similar respiratori condit reduc infect risk general experiment setup direct offlin breath sampl modifi certain mainstream side stream viral filter examin direct lab base applic confounderscontribut filter optimum oper condit assess observ immedi effect infect safeti mandat breath biomark profil main stream filter induc physiolog analyt effect side stream filter caus systemat analyt effect observ substanc specif effect part depend compound origin properti sampl flow respiratori rate offlin sampl storag time condit temperatur crucial method provid repeat condit point care lab base breath analysi low risk diseas transmiss besid breath voc profil spontan breath subject screen scenario covid similar test centr method protocol applic moderatelysever ill even mechan ventil high contagi patient intens care
|
D055549;D000086382
|
T047;T067;T109
|
36,289,275
|
signific chronic kidney diseas heart failur cardiovascular diseas mortal type diabet nationwid observ studi peopl type diabet substanti increas risk prematur death nationwid regist base cohort studi evalu signific risk factor previous cardiovascular diseas cvd heart failur chronic kidney diseas ckd mortal type diabet nationwid longitudin regist base cohort studi patient n list swedish nation diabet regist januari decemb includ follow decemb data retriev nation health registri patient uniqu identifi captur data clinic characterist outcom death describ mortal rate risk group mean follow time year patient year observ death correspond crude overal mortal deathsyear statist signific increas risk multivari analyz found older age group men underweight peopl normal bmi high hbac blood pressur histori cvd albuminuria advanc stage ckd associ increas risk mortal combin condit increas risk mortal result emphas import risk factor cardiovascular renal diabet complic peopl combin ckd cvd heart failur exhibit mark increas risk die prematur find provid strong argument optim individu treatment group peopl type diabet clinic everyday life
|
D002318;D003922;D051436;D006333
|
T047;T046
|
36,289,274
|
dark plume glacial meltwat affect vertic distribut zooplankton arctic polar region releas glacial meltwat result turbid plume expect transform coastal water numer consequ marin ecosystem studi aim determin influenc turbid regim vertic distribut copepod togeth potenti food chlorophyl fluoresc non visual predat gelatin zooplankton hydrographi turbid suspend particul matter chlorophyl studi juli august west spitsbergen water european arctic fine scale vertic distribut pattern zooplankton assess optic counter lopc underwat camera uvp verifi plankton net water shallow impact dark plume calanus spp gelatin zooplankton concentr upper water layer wherea area thick turbid layer distribut even water column howev chlorophyl peak found restrict surfac turbid water subsurfac maxima shallow turbid regim regardless region turbid regim signific factor shape vertic distribut calanus spp specul similar trend might observ rapid emerg turbid ecosystem urg futur plankton research also includ relat simpl turbid measur
|
D015048;D033342
|
T204
|
36,289,273
|
psycholog well covid pandem itali assess four wave survey covid pandem negat impact mental health well wb citizen cross section studi includ wave data collect aim identifi profil individu differ level wb studi includ repres stratifi sampl respond itali item well scale use assess wb differ supervis machin learn approach multinomi logist regress partial least squar discrimin analysi pls da classif tree ct appli identifi individu characterist differ wb score first wave subsequ wave forti one percent particip report good wb poor wb depress find carri use multinomi logist regress show resili import variabl abl discrimin wb across wave pls da increas unhealthi behaviour prove import featur first two wave financi situat gain relev last two covid perceiv risk relev less variabl across wave interest use ct abl establish cut resili equal discrimin good wb probabl wave conclud found covid negat implic wb govern support evid base strategi consid factor influenc wb ie resili perceiv risk healthi behaviour financi situat
|
D000086382
|
T047;T067
|
36,289,272
|
acsl promot imatinib induc chronic myeloid leukemia cell senesc regul sirtpp pathway although tyrosin kinas inhibitor tkis improv prognosi chronic myeloid leukemia cml patient resist tkis residu leukemia stem cell lscs inevit becom bottleneck cure therefor need explor novel treatment strategi base convent treatment strategi previous studi found cml cell senesc may one main factor achiev clinic cure cml studi shown lipid metabol play key role cellular senesc found long chain acyl coa synthetas acsl signific regul senesc cml cell furthermor demonstr overexpress acsl induc senesc inhibit cell growth k cell alter cell cycl progress enhanc prolifer inhibit effect imatinib overexpress acsl enhanc imatinib induc tumorigen declin k cell vivo knockdown acsl revers imatinib induc senesc k cell mechanist overexpress acsl induc senesc k cell via sirtpp axi collect studi show acsl promot imatinib induc k cell senesc tumor growth regul sirtpp pathway acslsirtp signal axi novel mechan cell senesc cml new potenti target erad cml lscs
|
D056564;D015464
|
T191;T126;T116
|
36,289,271
|
promis sar cov main proteas inhibitor ligand bind mode evalu use lb pac mdfmo parallel cascad select molecular dynam base ligand bind path sampl lb pac md combin fragment molecular orbit fmo calcul reveal ligand path aqueous solut sar cov main proteas pro activ site customis ligand bind pocket suitabl deliv potent inhibitor rubraxanthon exhibit mix inhibit antivir activ sar cov pro relat low cytotox high cellular inhibit howev atom inhibit mechan remain ambigu lb pac mdfmo hybrid ligand bind evalu method elucid rubraxanthon interact sar cov pro first step lb pac md regard flexibl dock effici sampl set ligand bind pathway reason dock pose lb pac md evalu fmo calcul elucid set protein ligand interact enabl one know bind affin specifi ligand respect target protein possibl conform propos rubraxanthon bind sar cov pro activ site alloster inhibit elucid combin blind dock k mean cluster interact profil key bind residu consider interact elucid rubraxanthon bind pro site integr lb pac mdfmo provid reason complex structur ligand bind sar cov pro activ site vital discov design antivir drug
|
D000086402;D000086382
|
T005;T067;T047
|
36,289,270
|
environment relev concentr antipsychot drug sulpirid clozapin induc abnorm dopamin serotonin signal zebrafish brain presenc drug surfac groundwat advers affect physiolog function non target organ due special activ pose serious threat various form aquat life psychotrop drug one common use drug world henc aim studi investig effect environment relev concentr antipsychot drug sulpirid clozapin dopaminerg daergic serotonerg htergic neurotransmitt system brain zebrafish adult zebrafish ab strain expos environment relev concentr sulpirid clozapin mixtur sulpirid clozapin effect drug mrna protein level major function molecul daergic htergic system analyz telencephalon diencephalon drug induc abnorm mrna protein level import function molecul da ht signal pathway telencephalon diencephalon shown abnorm transcript level th dat dr dr mao tph serotonin transport sert htr aa htr b thr aa htr b abnorm translat level dat dr sert htr htr b htr b addit observ specif advers effect antipsychot drug term dose brain part compar effect alon drug mixtur weaker effect da ht system suggest antagonist interact sulpirid clozapin find suggest sulpirid clozapin interfer daergic htergic neurotransmitt system telencephalon diencephalon zebrafish result possibl effect brain function pose serious threat health zebrafish
|
D003024;D014150
|
T121;T039;T109
|
36,289,269
|
impact somatostatin interneuron interact barrel plastic induc whisker depriv activ inhibitori interneuron profound role shape cortic plastic somatostatin express interneuron som in involv sever aspect experi depend cortic rewir address question barrel cortex som engag plastic format induc sensori depriv adult mice month old use spare vibrissa paradigm result massiv sensori map reorgan use chemogenet manipul activ barrel cortex som in block activ continu clozapin n oxid cno administr one week long depriv visual depriv induc plastic c deoxyglucos map cortic function represent spare whisker perform end depriv plastic manifest extens cortic activ respons spare vibrissa stimul found som inhibit cortic column spare whisker influenc areal extent cortex activ spare whisker howev block activ som in depriv column adjac spare one decreas plastic spare whisker represent som activ affect plastic data show som activ part cortic circuitri affect interbarrel interact under depriv induc plastic adult mice
|
D014738;D013003
|
T023;T029
|
36,289,268
|
season nearshor ocean acidif deoxygen southern california bight california current system experi season ocean acidif hypoxia oah owe wind driven upwel littl known intens frequenc depth distribut oah shallow nearshor environ present observ oah dissolv inorgan carbon nutrient paramet base month transect march septemb extend surf zone depth contour la jolla california biolog concern oah condit observ depth shallow close shorelin depth observ undersatur respect aragonit observ ph less observ subleth oxygen threshold mol kg observ rais import question impact oah coastal organ ecosystem futur intensifi upwel may exacerb condit
|
D017753;D012623
|
T167;T070;T082
|
36,289,267
|
detect hz auditori steadi state respons optic pump magnetomet magnetoencephalographi meg function neuroimag techniqu noninvas detect brain magnet field neuron activ convent meg measur brain signal use superconduct quantum interfer devic squid squid meg requir cryogen environ involv bulki non magnet dewar flask consumpt liquid helium restrict variabl sensor array gap cortic sourc sensor recent miniatur optic pump magnetomet opm develop commerci opm requir cryogen cool place within millimet scalp present studi arrang six opm sensor tempor area detect auditori relat brain respons two layer magnet shield room present auditori stimuli khz pure tone burst ms durat obtain compon auditori evok field deliv period stimuli hz repetit rate observ gamma band power chang inter trial phase coher auditori steadi state respons hz found opm sensor perform compar convent squid meg sensor result suggest feasibl use opm sensor function neuroimag brain comput interfac applic
|
D006371;D015225
|
T060;T121;T196
|
36,289,266
|
artifici intellig base method fusion electron health record imag data healthcar data inher multimod includ electron health record ehr medic imag multi omic data combin multimod data sourc contribut better understand human health provid optim person healthcar import question use multimod data fuse field grow interest among research advanc artifici intellig ai technolog particular machin learn ml enabl fusion differ data modal provid multimod insight end scope review focus synthes analyz literatur use ai techniqu fuse multimod medic data differ clinic applic specif focus studi fuse ehr medic imag data develop various ai method clinic applic present comprehens analysi various fusion strategi diseas clinic outcom multimod fusion use ml algorithm use perform multimod fusion clinic applic avail multimod medic dataset follow prisma scr prefer report item systemat review meta analys extens scope review guidelin search embas pubm scopus googl scholar retriev relev studi pre process screen extract data studi fulfil inclus criteria found studi fuse imag data ehr increas doubl analysi typic workflow observ feed raw data fuse differ data modal appli convent machin learn ml deep learn dl algorithm final evalu multimod fusion clinic outcom predict specif earli fusion use techniqu applic multimod learn studi found multimod fusion model outperform tradit singl modal model task diseas diagnosi predict common clinic outcom report studi respect clinic outcom perspect neurolog disord domin categori studi ai perspect convent ml model use studi follow dl model studi multimod data use includ studi most privat repositori studi scope review offer new insight research interest know current state knowledg within research field
|
D001185;D057286
|
T090;T170;T073;T066
|
36,289,265
|
foundat plant speci provid resili microclimat heterogen dryland climat chang profound influenc plant anim ecosystem includ dryland semi arid arid scrubland grassland peak extend megadrought southwestern usa microclimat refug provid foundat plant speci associ veget examin shrub open interstiti space without canopi annual plant instrument wet season central dryland california year season test veget signific mediat fine scale near surfac air temperatur relat soil moistur content defin microclim foundat speci veget provid signific thermal refug potenti capac plant anim variat grow season soil moistur content frequent increas direct canopi effect shrub evid suggest climat mani plant anim experi even extend megadrought mediat local plant high impact dryland anthropogen disturb signific water induc challeng foundat speci shrub dryland function potent start point examin ecolog relev climat scale german mani speci local ecolog framework climat resili use shrub improv conserv restor plan dryland
|
D017753;D008834
|
T070;T082
|
36,289,264
|
ferritin threshold cardiac liver hemosiderosi thalassemia patient diagnost accuraci studi ferritin frequent use screen dire consequ iron overload thalassemia patient studi aim defin best cutoff point ferritin screen cardiac liver hemosiderosi case registri base studi thalassemia patient live throughout mazandaran provinc iran n diagnost research index test ferritin level measur chemiluminesc immunoassay refer test weight magnet reson imag weight mri appli determin cardiac liver hemosiderosi cutoff point ngml ferritin show sensit specif ppv npv cardiac hemosiderosi area curv auc ci adjust odd ratio ci optimum cutoff point ngml sensit specif ppv npv liver hemosiderosi estim auc ci adjust ci likelihood cardiac hemosiderosi serum ferritin level ngml moreov thalassemia patient serum ferritin level ngml may suffer liver hemosiderosi regardless grade
|
D006486;D017086;D019190
|
T047
|
36,289,262
|
bond specif fragment oligopeptid via electron stop swift heavi ion molecular film high bond specif fragment oligopeptid induc swift heavi ion shi irradi investig mean mass spectrometri pronounc contrast measur sampl irradi kev ion oligopeptid expos mev au ion show high abund specif fragment high bond specif natur shi induc fragment attribut electron stop relev energi loss mechan shi oligopeptid sampl combin subsequ coupl excit electron atom subsystem fragment induc shi observ influenc structur oligopeptid suggest electron excit andor electron vibrat coupl depend detail molecular structur
|
D020450
|
T196
|
36,289,261
|
paleomagnet techniqu date speleothem high concentr detrit materi u seri date young dirti speleothem challeng due difficulti assess isotop composit detrit contamin low abund th generat situ propos new date approach base comparison speleothem paleomagnet direct refer curv global paleomagnet reconstruct approach demonstr stalagmit collect soprador carvalho cave central region portug radioisotop age model built use four u seri age three c suggest relat steadi carbon precipit bce ce forti five mm thick subsampl analyz use altern field thermal demagnet protocol provid well defin primari magnet direct age model stalagmit obtain fit paleomagnet record refer paleosecular variat curv obtain previous paleo reconstruct model appli statist bootstrap analysi defin best fit result age model fit close radioisotop age model provid signific higher time resolut reach conclus appli approach anoth stalagmit algarv region portug approach thus appear promis altern date young speleothem high detrit content
|
D002254;D008280
|
T090;T121;T109
|
36,289,260
|
thermal acclim metabol scale groundwat asellid climat chang scenario metabol rate long use anim adapt perform studi individu oxygen consumpt use proxi metabol rate stygofauna organ adapt groundwat presum lower metabol rate surfac relat stygofauna cope global temperatur increas remain unpredict studi thermal acclim metabol scale bodi mass stygobit crustacean proasellus lusitanicus climat chang scenario measur oxygen consumpt rate thermal ramp experi four assay temperatur test two hypothes p lusitanicus exhibit narrow thermal plastic inadequ cope fast increas thermal regim ii oxygen consumpt rate scale bodi mass factor close common observ anim result show p lusitanicus low thermal plastic fast increas thermal regim data also suggest oxygen consumpt rate speci follow mass depend scale potenti repres new trait metabol optim groundwat habitat often limit food oxygen speci limit dispers capac rigid metabol guild face extinct risk due climat chang omit groundwat ecosystem climat chang agenda emphas unprotect status stygofauna
|
D057231;D060587
|
T081;T070;T082
|
36,289,259
|
hetastarch induc volum chang starv adenoma suggest mechan action submucos inject often requir step endoscop mucos resect emr clinic practic observ emr inject solut contain hetastarch hes lead select increas neoplasm volum facilit resect aim studi explor possibl mechan behaviour report elsewher hct cell line human colon cancer expos emr solut vitro signific volum increas hct cell observ starv cell cultur suggest starv essenti neoplasm specif volum chang suggest iso oncot composit emr submucosa inject solut hes compon crucial subject starch hydrolysi follow facilit transport result monosaccharid submucosa neoplast tissu
|
D000236;D000069916
|
T061;T191
|
36,289,258
|
intercellular interact mechan promot divers intracellular atp concentr escherichia coli popul fluctuat environ mani microorgan acquir phenotyp heterogen surviv tactic increas likelihood surviv overal popul one exampl interindividu heterogen divers atp concentr among member escherichia coli popul glucos depriv despit import environment driven phenotyp heterogen differ intracellular atp concentr emerg among individu e coli organ unknown studi focus mechan individu e coli achiev high intracellular atp concentr first measur atp retain e coli time cultur low mm control mm concentr glucos obtain chronolog chang atp concentr compar chronolog chang atp concentr analyz whether stochast state transit period oscil cellular age intercellular communic report molecular biolog mechan generat interindividu heterogen involv show appear high atp hold individu observ among e coli explain intercellular transmiss perform metabolom analysi post cultur medium reveal signific increas atp especi low glucos number e coli retain signific higher atp control ad larg amount atp medium even popul cultur control glucos concentr result reveal first time atp mediat intercellular transmiss enabl individu e coli popul grown low glucos retain larg amount atp
|
D004926;D005947
|
T121;T123;T007;T109
|
36,289,257
|
feasibl transthorac esophagectomi next generat surgic robot robot assist minim access surgeri mas compar convent mas shown number benefit across sever therapeut indic use transthorac esophagectomi tte requir evalu report first human seri major esophag resect perform use next generat tele oper robot surgic system singl center robot assist tte perform use versius surgic system singl surgeon assess robot system abil achiev tumor clearanc measur r resect rate whilst reduc anastomot leakag rate intra post oper outcom median oper time length hospit intra oper blood loss number complic also assess fifti seven patient underw robot assist tte august june procedur complet success unplan convers altern surgic method estim blood loss minim advers event complic death report experi versius surgic system demonstr safe adopt implement tte
|
D012371;D004938
|
T090;T191
|
36,289,255
|
plant growth acceler use transpar eu paint uv red convers film stimul photosynthesi strategi achiev sustain plant product red light use plant growth absorb chlorophyl pigment initi natur photosynthet process ultraviolet uv red wavelength convert materi promis candid eco friend plant cultur requir electr power studi transpar film equip uv red wavelength convert luminophor eu complex prepar commerci avail plastic film plant growth experi present eu base film absorb uv light exhibit strong red luminesc sunlight eu paint film provid signific growth acceler size increment biomass product veget crop tree northern region plant cultur eu paint film fold height fold total bodi biomass cultur without eu luminophor present film promot plant product field agricultur forestri
|
D010788;D002734
|
T123;T070;T109;T039;T044
|
36,289,254
|
histoarchitectur fibrillari matrix human fetal posterior tibial tendon adult tendon high differenti matur individu tendon heal injuri occur fibrot tissu format understand intrins repar properti fetal tendon would help understand matur tissu process tendon tissu repair present studi evalu evolut histoarchitectur cellular distribut collagen iii v posterior tibial tendon human fetus differ gestat age morpholog profil assess nine fresh spontan abort fetus group five fetus age week gestat group ii four fetus age week gestat character combin histolog fluoresc immunohistochemistri group posterior tibial tendon show statist signific greater cellular presenc collagen iii v group ii tendon show predomin collagen better organ extracellular matrix compar group tendon addit statist signific higher rate cd marker mesenchym cell found group tendon fetus gestat age week posterior tibiali tendon show thin disorgan fibrillar structur increas collagen iii v fiber mesenchym cell posterior tibiali tendon fetus gestat age week fibrillar structur thicker statist signific increas type collagen decreas cellular
|
D024042;D013710
|
T123;T023;T116
|
36,289,253
|
microrna p negat regul txnip express reliev inflammatori respons brain induc lipopolysaccharid sepsi one common caus death patient suffer sever infect injuri current specif effect therapi remain establish present studi mir p mir mir b p mir p mir b p mir p mir p mir b mir mir p predict target txnip mrna databas mirdb targetscan microt cds luciferas report assay confirm mir p negat regul txnip express elisa analys western blot demonstr mir p downregul product il il il tnf lipopolysaccharid lps stimul cell rat well protein level txnip nlrp cleav caspas addit mir p increas cell viabil decreas apoptosi lps stimul ctx tna cell reduc abnorm morpholog brain lps stimul rat besid mir p decreas relat mean fluoresc intens dcf lps stimul ctx tna cell apoptosi protein level mnsod catalas lps stimul brain find indic mir p downregul lps induc inflammatori respons reactiv oxygen speci product brain damag suggest mir p candid treatment septic encephalopathi
|
D008070;D035683
|
T123;T114;T109
|
36,289,252
|
viscosupplement upper lower compart temporomandibular joint check ultrasonographi ex vivo vivo studi viscosupplement vs temporomandibular joint tmj aim treat temporomandibular dysfunct tmd stimul synovi cell improv intracapsular lubric purpos present studi assess vs protocol plan aid cone beam comput tomographi cbct check ultrasonographi us studi carri stage first check correspond propos facial refer point osseous compon joint mean cbct second stage upper lower compart tmjs fresh frozen cadav inject colour liquid accuraci techniqu confirm dissect anatom specimen third stage consist vs patient tmjs real time verif locat needl tip mean ultrasonographi cbct confirm correct locat mark point use propos vs protocol dissect show inject effect reach upper lower compart locat needl tip effect verifi ultrasonographi confirm correct access compart propos protocol effect access upper lower compart tmj evalu protocol prove accur safe clinic reproduc mean vs upper lower compart tmj
|
D013705;D055676
|
T061;T047
|
36,289,251
|
languag opinion chang social media len communic action messag effect induc chang opinion listen approach question within frame haberma theori communic action posit illocutionari intent messag pragmat mean key thank recent advanc natur languag process abl operation theori extract latent social dimens messag name archetyp social intent languag come social exchang theori identifi key ingredi opinion chang look k post comment reddit rchangemyview debat forum peopl tri chang opinion explicit mark opinion chang comment special flag call delta comment express intent less like chang mind recipi compar comment convey least one social dimens among various social dimens one like produc opinion chang knowledg similar trust reson haberma theori communic action also find new import dimens appeal power empathet express support final line theori construct conflict yet contrari popular character conflict bane modern social media find show voic conflict context structur public debat promot integr especi use counter anoth conflict stanc leverag recent advanc natur languag process work provid empir framework haberma theori find concret exampl effect wild suggest possibl extens facet understand intent interpret social dimens languag
|
D061108
|
T170
|
36,289,250
|
import malaria definit minimum data surveil mobil malaria infect individu pose challeng elimin campaign way spread parasit drug resist strain countri countri collabor make routin data collect difficult especi resourc poor set nevertheless concert effort made develop common framework defin spatial tempor compon import malaria case recommend minimum data need identifi conduct scope review import malaria literatur show definit vari wide local capabl detect import often restrict low incom countri follow propos common definit import malaria minimum data requir identifi case depend countri capabl conduct epidemiolog investig last util propos definit use data brazil demonstr feasibl import track import case case brazil highlight capabl regular surveil system monitor import also need regular use data inform local respons support countri use regular collect data adopt common definit paramount tackl import malaria case achiev elimin goal set forth world health organ
|
D008288
|
T047
|
36,289,249
|
copper adorn magnet nanoparticl heterogen catalyst sonogashira coupl reaction aqueous media nanomagnet hydrophil heterogen copper catalyst term fe peg pamam g cu success prepar character use ft ir xrd fe sem tem edx map tgadtg vsm icp analys catalyst display excel activ palladium free sonogashira cross coupl reaction various aryl iodid bromid phenylacetylen deriv pure water presenc polyethylen glycol coupl hydrophil charact cu catalyst adorn fe mnps provid readi dispers catalyst particl water lead higher catalyt perform well facil catalyst recoveri via simpl magnet decant recov catalyst reus least six success run littl reduct catalyt activ notic chang structur use water green solvent without requir addit organ solvent well exploit abund low cost copper catalyst instead expens pd catalyst along catalyst recoveri scalabl make method favor environment econom point view sonogashira coupl reaction
|
D003300;D058185
|
T123;T196;T121;T130
|
36,289,247
|
optim set advantag drone tool canopi arthropod collect grow field aeroecolog limit difficulti associ sampl air column aerial insect particular hard sampl despit main prey air column recent studi attempt use drone collect method conduct studi determin optim drone set collect insect canopi drone seldom use attach net bodi small commerci drone test yield differ height speed net set wetland well compar insect divers across differ habitat canopi height import set graze canopi yield signific insect fli one meter speed drone type net size influenc number insect caught per trial wetland canopi higher abund divers speci rich arthropod popul compar forest canopi lake compar yield lindgren funnel tradit sampl method entomolog drone captur higher divers abund insect fraction time studi confirm drone effici accur way collect canopi arthropod
|
D001181
|
T204
|
36,289,246
|
databas sar cov coronavirus kinet relev assess persist food process plant sar cov sever acut respiratori syndrom coronavirus virus caus sever acut respiratori diseas human emerg late respiratori virus spread via aerosol fomit contamin hand surfac coronavirus studi persist differ environment condit repres key step better understand virus transmiss work aim present reproduc procedur collect data stabil inactiv kinet scientif literatur aim identifi data use character persist virus food product plant result larg dataset relat persist matric liquid media differ environment condit present procedur combin bibliograph survey data digit techniqu predict microbiolog model identifi research articl provid coronavirus kinet rank step well technic valid gage repeat amp reproduc process perform check qualiti kinet data deposit public repositori futur use research
|
D000086382;D000086402
|
T047;T005;T067
|
36,289,245
|
wide applic extend flow cytometr stem cell enumer panel qualiti control advanc cellular product wide use qualiti control assay cd hematopoiet stem cell product character protocol establish intern societi hematotherapi graft engin ishag protocol still gold standard stem cell enumer viabil assess includ cell enumer nowaday mandatori assay standard allogen graft various advanc therapi medicin product atmp accord develop extens valid new approach comprehens character hematopoiet cellular product use pre formul dri antibodi format panel addit count bead typic marker cd fluorescein isothiocyan fitc cd phycoerythrin pe well viabil dye amino actinomycin aad novel pre formul panel also contain cd pacif blue pb cd allophycocyanin apc tube therebi allow combin calcul leucocyt stem cell b cell show high linear sensit accuraci approach easi implement enabl depth character cellular product releas test condit addit dri pre formul antibodi approach increas assay reliabl compar standard antibodi panel
|
D010799;D006412
|
T123;T116;T025
|
36,289,244
|
oral administr human carbon anhydras suppress coliti murin inflammatori bowel diseas model incid inflammatori bowel diseas ibd increas henc effect treatment warrant therapeut effect human carbon anhydras hca ibd remain unknown therefor investig whether oral toler hca would induc antigen specif protect intestin inflamm vivo sever combin immunodefici mice receiv hca keyhol limpet hemocyanin klh phosphat buffer salin pbs oral day colon mesenter lymph node mlns collect week cell transfer addit mechan under therapeut effect investig comparison effect well establish drug hca oral administr investig oral administr hca amelior coliti remark hca reach cecum amelior coliti effect mesalazin similar prednisolon compar pbs treatment hca treatment reduc interleukin il il retino acid relat orphan receptor gamma rort express colon mlns moreov hca mark reduc il il interferon gamma ifn level mln oral administr hca induc immun toler suppress coliti vivo thus hca administr could propos new treatment option ibd
|
D003092;D015212
|
T047
|
36,289,242
|
incid predictor brain infarct neonat patient extracorpor membran oxygen observ cohort studi determin incid identifi predictor brain infarct bi neonat patient treat extracorpor membran oxygen ecmo perform retrospect cohort studi ecmo centr karolinska stockholm sweden logist regress model use identifi bi predictor neonat age day treat veno arteri va veno venous vv ecmo primari outcom comput tomographi ct verifi bi diagnos ecmo treatment total patient includ patient underw least one brain ct patient diagnos bi bi diagnosi associ increas day mortal vs high pre ecmo pediatr index mortal score sepsi indic ecmo treatment va ecmo convers ecmo mode use continu renal replac therapi extracrani thrombosi identifi independ predictor bi develop incid bi neonat ecmo patient may higher previous understood risk factor identif may help initi step lower risk facilit earlier diagnosi bi neonat undergo ecmo treatment
|
D015199
|
T061
|
36,289,240
|
dynam post occlus water diffus stratum corneum diffus water membran present consider challeng diffus often depend local concentr water one particular exampl strong biolog relev stratum corneum sc primari permeabl barrier skin simpl altern constant diffus model provid fujita two paramet ration approxim captur experiment observ fact sc diffus constant water increas increas water concentr base fick law diffus one dimension concentr depend diffus model develop appli analysi steadi state transepiderm water loss tewl non steadi state call skin surfac water loss sswl occur remov occlus patch sc surfac shown age relat chang sswl qualit explain variat dimensionless fujita concentr depend paramet
|
D014867;D004817
|
T121;T197;T024
|
36,289,235
|
eya control affin cell lineag drive tissu self organ drosophila oogenesi cooper morphogenesi cell lineag under develop function unit organ studi mechan drive coordin lineag investig soma germlin interact oogenesi invertebr vertebr oocyt develop part germlin cyst consist oocyt call nurs cell feed oocyt eventu remov envelop somat cell special facilit either oocyt matur nurs cell remov make essenti establish right match germlin somat cell uncov transcript regul eya express somat lineag control bilater cell cell affin germlin somat cell drosophila oogenesi employ function studi mathemat model show differenti affin result forc drive somat cell redistribut germlin surfac control oocyt growth match oocyt nurs cell respect somat cell thus data demonstr differenti affin cell lineag suffici drive complex assembl inter lineag function unit under tissu self organ drosophila oogenesi
|
D004330;D029721
|
T123;T116;T204
|
36,289,234
|
dataset compris bind interact antibodi sar cov peptid dataset present contain quantit bind score scfv format antibodi sar cov target peptid collect via alphaseq assay use develop benchmark machin learn model start three seed sequenc identifi phage display campaign use human nave librari four set antibodi design silico creat k mutat random k k mutat throughout complementari determin region cdrs design success built alphaseq librari target bind subsequ measur design result predict affin valu least one triplic measur data includ antibodi predict affin measur rang pm mm knowledg dataset largest public avail dataset contain antibodi sequenc antigen sequenc quantit measur bind score provid opportun serv benchmark evalu antibodi specif represent model machin learn
|
D000086382;D057127
|
T129;T047;T067
|
36,289,233
|
crystal structur na h antiport nhaa activ ph reveal mechanist basi ph sens strict exchang proton sodium ion across cell membran na h exchang fundament mechan cell homeostasi activ ph na h exchang model competit h na ion bind site harbour either one two aspart acid residu nevertheless extens analysi model na h antiport nhaa escherichia coli shown residu cytoplasm surfac term ph sensor shift ph nhaa becom activ unclear incorpor ph senor model altern access mechan base nhaa structur inact ph report crystal structur nhaa activ ph improv resolut show ph residu ph sensor rearrang form new salt bridg interact involv key histidin residu widen inward face caviti refer ph gate trigger conform chang enabl water na access ion bind site support molecular dynam md simul work highlight uniqu channel like switch prior substrat transloc secondari activ transport
|
D029968
|
T116
|
36,289,231
|
rescu deficit brwd copi number restor tsdn mous model syndrom incid birth syndrom ds common chromosom condit link intellectu disabl worldwid genet basi ds identifi triplic chromosom hsa gene encod hsa direct contribut cognit deficit remain incomplet understood found hsa encod chromatin effector brwd upregul neuron deriv ip cell individu syndrom brain trisom mice show select copi number restor brwd trisom anim rescu deficit hippocamp ltp cognit gene express demonstr brwd tight bind baf chromatin remodel complex increas brwd express promot baf genom mistarget import brwd renorm rescu aberr baf local along associ chang chromatin access gene express find establish brwd key epigenom mediat normal neurodevelop import contributor ds relat phenotyp
|
D004314;D003072
|
T047;T048
|
36,289,228
|
freshwat microbi metagenom sampl across differ water bodi characterist space time israel freshwat bodi critic compon terrestri ecosystem microbi communiti freshwat ecosystem intim link water qualiti microb interact util recycl inorgan element organ matter present three metagenom sequenc dataset total gbp differ freshwat environ israel first dataset divers freshwat bodi intend differ usag natur reserv irrig aquacultur facil tertiari wastewat treatment plant desert rainfal reservoir second repres two year time seri collect rough month interv water reservoir connect aquacultur facil third sever time point winter spring lake kinneret includ bloom cyanobacterium microcysti sp dataset accompani physic chemic biolog measur sampl point expect metagenom facilit wide rang compar studi seek illumin new aspect freshwat microbi ecosystem inform futur water qualiti manag approach
|
D000458;D054892
|
T007;T028
|
36,289,227
|
robot assist acoustofluid end effector liquid manipul foundat laboratori process macroscal liquid handl commerci robot system avail howev microscal reagent expens sampl prepar difficult last decad lab chip loc system come serv microscal liquid manipul howev lack autom multi function despit potenti synergi grown separ suitabl interfac yet exist link macro level robot micro level loc microfluid devic present robot assist acoustofluid end effector raee system compris robot arm acoustofluid end effector combin robot microfluid function carri fluid pump particl zebrafish embryo trap mobil mix complex viscous liquid final pre program raee perform autom mix viscous liquid well plate illustr versatil automat execut chemic process
|
D012371
|
T090
|
36,289,226
|
fosb accumul hippocamp granul cell drive cfos pattern separ spatial learn mice display sign fear neuron express cfos fear condit artifici reactiv find gave rise notion cfos mark neuron encod specif memori show cfos express pattern mous dentat gyrus dg chang dramat day day water maze spatial learn paradigm regardless train level optogenet inhibit neuron express cfos first train day affect perform day later suggest neuron continu import spatial memori recal mechan prevent repeat cfos express dg granul cell involv accumul fosb long live splice variant fosb ca neuron contrast repeat express cfos thus cfos express granul cell may encod new featur ad intern represent last train session form timestamp thought requir format episod memori
|
D018891;D065853
|
T023;T041
|
36,289,225
|
function metabol alter gut microbiota children new onset type diabet gut dysbiosi link type diabet td howev microbi capac td remain unclear integr profil gut microbi function metabol alter children new onset td independ cohort investig under mechan td microbiota character decreas butyr product bile acid metabol increas lipopolysaccharid biosynthesi speci gene metabolit level combin bacteri speci fecal metabolit provid excel discriminatori power td gut microbiota children td induc elev fast glucos level declin insulin sensit antibiot treat mice streptozotocin induc td mice butyr lipopolysaccharid exert protect destruct effect islet structur function respect lipopolysaccharid aggrav pancreat inflammatori respons butyr activ insulin insulin gene express studi reveal perturb microbi function metabol trait td provid potenti avenu microbiom base prevent intervent td
|
D000069196;D003922
|
T047;T007;T001
|
36,289,224
|
v bypass suppress lead direct specif microsaccad modul visual code percept microsaccad play critic role refresh visual inform shown direct specif influenc human percept howev neural mechan under direct specif effect remain unknown report emerg direct specif microsaccad modul middl layer v v respons v neuron microsaccad move toward recept field stronger microsaccad move away decreas respons v v correl amplitud microsaccad away recept field suggest topograph locat specif suppress oculomotor sourc consist direct effect v microsaccad function guid monkey behavior peripher detect task explain dynam neural network find suggest v bypass suppress circuit direct specif microsaccad modul v function influenc visual sensit highlight optim sampl natur microsaccad
|
D012438;D005133
|
T033;T039
|
36,289,223
|
subcellular spatial transcriptom identifi three mechanist differ class local rnas intracellular rna local widespread dynam phenomenon compartment gene express contribut function polar cell thus far mechan rna local identifi drosophila base rnas differ tissu comprehens mechanist analysi rna local singl tissu lack subcellular spatial transcriptom identifi rnas local apic basal domain columnar follicular epithelium fe analyz mechan mediat local wherea dyneinbicdegl machineri control apic rna local basal target rnas requir kinesin overcom default dynein mediat transport moreov non canon translat dynein depend mechan mediat apic local subgroup dynein activ adaptor encod rnas bicd bsgd hook altogeth studi identifi least three mechan under rna local fe suggest possibl link rna local dyneindynactinadaptor complex format vivo
|
D004398;D029721
|
T123;T126;T116
|
36,289,222
|
mettl acetyl imped cancer metastasi via fine tune nuclear cytosol function methyltransferas like mettl general recogn nuclear protein bear oncogen properti find predomin cytoplasm mettl express invers correl node metastasi human cancer remain unclear nuclear mettl function distinct cytosol mettl drive tumorigenesi tumor cell sens oncogen insult coordin mettl function within intracellular compart report acetyl depend regul mettl local impact metastat dissemin identifi il depend posit feedback axi facilit nuclear mettl function elicit breast cancer metastasi il whose mrna transcript subject mettl mediat modif promot mettl deacetyl nuclear transloc therebi induc global abund deacetyl mediat nuclear shift mettl counterbalanc sirt inhibit process enforc aspirin treatment lead ablat lung metastasi via impair methyl intrigu acetyl mimet mettl mutant reconstitut result enhanc translat compromis metastat potenti studi identifi acetyl depend regulatori mechan determin subcellular local mettl may provid mechanist clue develop therapeut strategi combat breast cancer metastasi
|
D008780;D001943
|
T191;T126;T116
|
36,289,221
|
kynurenin promot neonat heart regener stimul cardiomyocyt prolifer cardiac angiogenesi indoleamin dioxygenas ido catalyz tryptophan kynurenin metabol mani inflammatori cancer diseas note acut inflamm occur immedi heart injuri essenti neonat cardiomyocyt prolifer heart regener howev ido catalyz tryptophan metabol heart regener larg unexplor find apic neonat mous heart resect surgeri led rapid consist increas cardiac ido express kynurenin accumul cardiac delet ido gene chemic inhibit ido impair heart regener mechanist elev kynurenin trigger cardiomyocyt prolifer activ cytoplasm aryl hydrocarbon receptor src yaperk pathway addit cardiomyocyt deriv kynurenin transport endotheli cell stimul cardiac angiogenesi promot aryl hydrocarbon receptor nuclear transloc enhanc vascular endotheli growth factor express notabl ahr delet prevent indoleamin dioxygenas kynurenin associ heart regener summari increas indoleamin dioxygenas deriv kynurenin level promot cardiac regener function endogen regul cardiomyocyt prolifer cardiac angiogenesi
|
D007737;D018336
|
T123;T116;T192
|
36,289,220
|
reveal trcp activ dynam live cell genet encod biosensor f box protein beta transducin repeat contain protein trcp act substrat adapt scf e ubiquitin ligas complex play crucial role cell physiolog often deregul mani type cancer develop fluoresc biosensor quantit measur trcp activ live singl cell real time find trcp remain constitut activ throughout cell cycl function maintain discreet steadi state level substrat find correl express level trcp trcp activ indic post transcript regul high throughput screen small molecul use report identifi receptor tyrosin kinas signal key axi regul trcp activ inhibit bind trcp core scf complex studi introduc method monitor trcp activ live cell identifi key signal network regul trcp activ throughout cell cycl
|
D044783;D015374
|
T059;T116;T075
|
36,289,219
|
fibroblast govern fibrosi suscept repress dream promot fibrosi multipl organ addit autoimmun inflammatori diseas variant tnfaip gene encod ubiquitin edit enzym also associ fibrosi system sclerosi ssc howev remain unclear genet factor contribut ssc pathogenesi cell type drive diseas due ssc specif genet alter therefor character express function role negat transcript regul dream patient ssc diseas model level signific reduc ssc skin lung dream elev isol fibroblast mitig ex vivo profibrot respons mice haploinsuffici harbor fibroblast specif delet recapitul major patholog featur ssc wherea dream null mice elev express protect dream null fibroblast tgf induc express compar wild type fibroblast anti fibrot small molecul target cellular adiponectin receptor stimul express vitro wild type defici fibroblast bleomycin treat mice thus novel cell intrins function restrain fibroblast activ togeth dream constitut critic regulatori network govern fibrot process ssc dream repres novel druggabl target fibrosi therapi
|
D054419;D012595
|
T047;T116;T192
|
36,289,218
|
multi omic character autophagi relat molecular featur therapeut target autophagi autophagi major contributor anti cancer therapi resist mani effort made understand overcom autophagi mediat therapi resist effort unsuccess clinic applic studi establish autophagi signatur estim tumor autophagi status classifi approxim tumor sampl across cancer type cancer genom atlas autophagi score high autophagi score low group character associ multi dimension molecular featur tumor autophagi analys effect autophagi status drug respons contrast convent view induct autophagi serv key resist mechan cancer therapi analysi reveal autophagi induct may also sensit cancer cell anti cancer drug experiment valid phenomenon sever anti cancer drug vitro vivo reveal autophagi induc potenti sensit tumor cell etoposid downregul express level ddit studi provid comprehens landscap molecular alter associ tumor autophagi highlight opportun leverag multi omic analysi util multipl drug sensit induc autophagi
|
D000970;D009369
|
T121;T191;T109
|
36,289,217
|
global thermal spring distribut relationship endogen exogen factor present digit analysi thermal spring world dataset compil gerald ashley ware collect analog map obtain geograph coordin geotherm spring area includ complementari data eg temperatur total dissolv solid flow rate make avail electron format use temperatur flow rate deriv heat discharg thermal spring area mw median valu mw mw total integr data set global data set studi relationship thermal endogen exogen factor supervis machin learn algorithm analysi confirm domin role terrestri heat flow topographi volcan extension tecton data set offer new insight boost futur studi geotherm energi explor
|
D045482
|
T070
|
36,289,215
|
myocardi trpc mediat zn influx induc benefici posit inotropi adrenoceptor baroreflex control cardiac contract posit inotropi sympathet nerv activ import cardiocirculatori homeostasi transient receptor potenti canon subfamili trpc channel respons adrenoceptor ar stimul cation entri upregul associ patholog cardiac remodel whether trpc channel particip physiolog pump function remain unclear demonstr trpc specif zn influx potenti adrenoceptor ar stimul posit inotropi rodent cardiomyocyt delet trpc impair sympathet nerv activ posit inotropi chronotropi mice trpc mediat zn influx boost ar stimul arg depend signal rat cardiomyocyt inhibit arrestin mediat ar intern replac two trpc specif amino acid pore region trpc residu diminish ar stimul zn influx posit inotrop respons pharmacolog enhanc trpc mediat zn influx prevent chronic heart failur progress mice data demonstr trpc mediat zn influx ar stimul enhanc baroreflex induc posit inotropi may new therapeut strategi chronic heart failur
|
D050052;D006333
|
T123;T047;T046;T116
|
36,289,211
|
ultrafast one minut electron detect sar cov infect cl pro enzymat activ untreat saliva sampl sinc onset decemb sever acut respiratori syndrom coronavirus sar cov caus million death worldwid octob attempt curb viral transmiss reli heavili reliabl test detect infect sinc larg number transmiss carri asymptomat individu mani avail detect method fall short term reliabl point care applic report electrochem approach target viral proteolyt enzym clpro marker activ infect detect proteolyt activ direct untreat saliva within one minut sampl incub use reduct oxid ph indic import clinic test saliva sampl subject show accur detect sar cov high sensit specif valid pcr test coupl platform ultrafast detect simplic low cost point care compat make promis method real world sar cov mass screen
|
D000086382
|
T047;T067
|
36,289,209
|
hifi metagenom sequenc enabl assembl accur complet genom human gut microbiota advanc metagenom assembl led discoveri genom belong uncultur microorgan metagenom assembl genom mag often suffer fragment chimer recent complet mag cmag assembl oxford nanopor long read sequenc human fecal sampl low nucleotid accuraci report cmag obtain pacif bioscienc pacbio high accuraci long read hifi metagenom sequenc five human fecal sampl whose initi circular contig select complet prokaryot genom use bioinformat workflow nucleotid accuraci final cmag high illumina sequenc cmag could exceed mbp includ complet genom divers taxa includ entir uncultur rf tanb order moreov cmag reveal region hard assembl short read sequenc compris most genom island rrnas hifi metagenom sequenc facilit catalog accur complet genom complex microbi communiti includ uncultur speci
|
D054892;D000069196
|
T001;T007;T028
|
36,289,208
|
fungal nrps pks enzym catalys format flavonoid naringenin biosynthesi flavonoid naringenin plant bacteria common catalys type iii polyketid synthas pks use one p coumaroyl coa three malonyl coa molecul substrat report fungal non ribosom peptid synthetas polyketid synthas nrps pks hybrid fnsa naringenin format feed experi isotop label precursor demonstr fnsa accept p coumar acid p ca also p hydroxybenzo acid p hba starter unit three four malonyl coa molecul elong respect vitro assay msms analysi prove p ca p hba first activ adenyl domain fnsa phylogenet analysi reveal pks portion fnsa share high sequenc homolog type pkss refactor biosynthet pathway yeast involv fnsa provid altern approach product flavonoid isorhamnetin acacetin
|
D048630;D005419
|
T121;T116;T127;T109;T126
|
36,289,207
|
polerovirus n termin readthrough domain structur reveal molecular strategi mitig virus transmiss aphid polerovirus enamovirus luteovirus icosahedr posit sens rna virus caus econom import diseas food fiber crop transmit phloem feed aphid circul manner involv movement across within insect tissu n termin portion viral readthrough domain n rtd implic key determin aphid transmiss genera report crystal structur n rtds polerovirus turnip yellow virus tuyv potato leafrol virus plrv resolut respect adopt two domain arrang uniqu interdigit topolog form high conserv dimer stabil c termin peptid critic proper fold demonstr plrv n rtd act inhibitor virus transmiss identifi n rtd mutant variant lethal aphid sequenc conserv argu enamovirus luteovirus n rtds follow structur blueprint afford biolog approach block spread agricultur pathogen generaliz manner
|
D001042;D052679;D017793
|
T005;T204
|
36,289,206
|
bias signal due oligomer g protein coupl platelet activ factor receptor g protein coupl receptor gpcrs import drug target mediat various signal pathway activ g protein engag arrestin protein despit import develop therapeut fewer side effect under mechan control balanc signal mode gpcrs remain larg unclear show assembl dimer oligom larg influenc signal mode platelet activ factor receptor pafr singl particl analysi result show pafr form oligom low densiti two possibl dimer interfac stabil pafr oligom cross link increas g protein activ decreas arrestin recruit agonist induc intern signific reciproc arrestin prevent pafr oligomer result highlight mechan involv control receptor signal therebi provid import insight relationship gpcr oligomer downstream signal
|
D010972;D043562
|
T192;T129;T116;T109
|
36,289,205
|
type diabet gene tyk regul cell develop respons interferon type diabet td autoimmun diseas result destruct insulin produc pancreat cell one gene associ td tyk encod janus kinas critic role type interferon ifn mediat intracellular signal studi role tyk cell develop respons ifn generat tyk knockout human ipsc direct pancreat endocrin lineag show loss tyk compromis emerg endocrin precursor regul kras express matur stem cell islet sc islet function affect sc islet loss inhibit tyk prevent ifn induc antigen process present includ mhc class class express enhanc surviv cd cell cytotox result identifi unsuspect role tyk cell develop support tyk inhibit adult cell potent therapeut target halt td progress
|
D003922;D061385
|
T121;T047
|
36,289,204
|
optogenet control immunotherapeut design cell post surgic cancer immunotherapi surgic resect main treatment option solid tumor yet cancer recurr surgic resect remain signific challeng cancer therapi recent advanc cancer immunotherapi enabl radic cure mani tumor patient technolog remain challeng appli side effect relat uncontrol immun system activ develop far red light control immunomodulatori engin cell flic load hydrogel scaffold enabl precis optogenet control cytokin releas ifn tnf il upon illumin experi bf melanoma resect mous model show flic load hydrogel implant place surgic wound site achiev sustain releas immunomodulatori cytokin lead prevent tumor recurr increas anim surviv moreov flic load hydrogel implant elicit long term immunolog memori prevent tumor recurr find illustr optogenet periop immunotherapi flic load hydrogel implant offer safe treatment option solid tumor base activ host innat adapt immun system inhibit tumor recurr surgeri beyond extend optogenet toolbox immunotherapi envis optogenet control live cell factori platform could deploy biomed context requir precis induct bio therapeut dosag
|
D062308;D009364
|
T063;T191
|
36,289,203
|
clonal somat copi number alter driver event inform drug sensit high grade serous ovarian cancer chromosom instabl major challeng patient stratif target drug develop high grade serous ovarian carcinoma hgsoc show somat copi number alter scnas frequent amplifi hgsoc cancer gene signific correl gene express methyl status identifi five preval clonal driver scnas chromosom amplif encompass myc pikca ccne kras tert multi region hgsoc data reason strong select prioritis key biomark target therapi use primari hgsoc spheroid model test interact vitro target therapi scnas myc chromosom copi number associ vitro clinic respons paclitaxel vitro respons mtorc inhibit activ mtor surviv pathway context myc amplifi hgsoc statist associ increas preval scnas gene pik pathway co occurr amplif myc gene pik pathway independ observ squamous lung cancer tripl negat breast cancer work show identifi co occurr clonal driver scna gene could use tailor therapeut precis medicin
|
D010051;D018284
|
T191
|
36,289,202
|
decreas suscept plasmodium falciparum dihydroartemisinin lumefantrin northern uganda artemisinin partial resist may facilit select plasmodium falciparum resist combin therapi partner drug evalu p falciparum isol collect northern uganda resist associ pfk cy av mutat emerg eastern uganda mutat uncommon ex vivo ring surviv assay isol mutat median surviv mutant mix wild type andor mutat pfcoronin falcipain signific greater surviv isol surviv mutat least one protein ex vivo growth inhibit assay suscept lumefantrin median ic vs nm p nm p target sequenc isol identifi multipl polymorph associ alter drug suscept notabl pfk decreas suscept lumefantrin p pfcrt mutat chloroquin resist p result rais concern regard activ artemeth lumefantrin first line antimalari uganda
|
D000962;D016778;D037621
|
T121;T047;T109
|
36,289,201
|
driver global mangrov loss gain social ecolog system mangrov forest store high amount carbon protect communiti storm support fisheri mangrov exist complex social ecolog system henc identifi socioeconom condit associ decreas loss increas gain remain challeng albeit import impact nation govern conserv polici mangrov conserv landscap scale assess date interact local econom pressur biophys driver assess relationship socioeconom biophys variabl mangrov chang across coastal geomorph unit worldwid global find driver loss also driver gain driver chang year associ econom growth appear revers shift negat impact mangrov first decad enabl mangrov expans second decad import find communiti forestri promot mangrov expans wherea convers agricultur aquacultur often occur protect area result high loss sustain develop communiti forestri co manag protect area promis strategi revers mangrov loss increas capac mangrov support human livelihood combat climat chang
|
D017753;D053833
|
T083;T070;T082
|
36,289,199
|
juxtaposit bub cdc phosphoryl mad catalyt mitot checkpoint complex assembl respons improp kinetochor microtubul attach mitosi spindl assembl checkpoint sac assembl mitot checkpoint complex mcc inhibit anaphas promot complexcyclosom therebi delay entri anaphas mcc compris mad cdc bubr bub assembl catalys unattach kinetochor mad mad platform mad bound close mad c mad recruit open mad mad self dimer interact combin mps kinas mediat phosphoryl bub mad acceler mcc assembl process requir mad c mad convers concomit bind cdc mad phosphoryl catalys mcc assembl poor understood character mps phosphoryl mad obtain structur insight phosphoryl specif mad cdc interact interact togeth mps phosphoryl depend associ bub mad generat tripartit assembl bub cdc onto c termin domain mad mad ctd addit identifi flexibl mad mad suggest cdc mad ctd interact bring mad interact motif mim cdc near mad thus mps depend format mcc assembl scaffold function posit orient cdc mim near mad therebi catalys format c mad cdc
|
D059566;D018797
|
T123;T116;T043
|
36,289,198
|
tab aggrav progress esophag squamous cell carcinoma enhanc catenin nuclear transloc fhl depend manner tab also name tnksbp bind protein tankyras found particip dna repair previous studi reveal involv tab radioresist esophag squamous cell carcinoma escc cell howev whether tab contribut escc tumorigenesi progress remain unclear studi found high express tab close associ poor prognosi patient escc tab silenc reduc escc cell prolifer invas vitro tumorigen metastasi vivo rna seq ip ms analysi reveal tab could affect catenin signal pathway via interact catenin furthermor tab prevent catenin phosphoryl gsk recruit four half lim protein fhl therebi promot catenin nucleus transloc result activ downstream target transcript escc cell find demonstr tab enhanc tumorigenesi esophag cancer promot activ catenin signal pathway provid new insight molecular mechan tab acceler progress escc
|
D004938;D000077277;D038501
|
T191;T126;T116
|
36,289,195
|
gasdermin mediat endoplasm reticulum stress via famb regul cardiomyocyt autophagi apoptosi doxorubicin induc cardiotox cardiomyocyt pyroptosi apoptosi play vital role pathophysiolog sever cardiovascular diseas recent studi reveal gasdermin gsdmd promot myocardi ir injuri via caspas gsdmd pathway also found gsdmd delet attenu myocardi ir mi injuri reduc cardiomyocyt apoptosi pyroptosi howev gsdmd mediat cardiomyocyt apoptosi protect myocardi function remain unclear found doxorubicin dox treatment result increas apoptosi pyroptosi cardiomyocyt caspas gsdmd could mediat dox induc cardiotox dic injuri interest gsdmd overexpress promot cardiomyocyt apoptosi attenu gsdmd knockdown notabl gsdmd overexpress exacerb dic injuri impair cardiac function vitro vivo enhanc dox induc cardiomyocyt autophagi mechanist gsdmd regul activ famb endoplasm reticulum autophagi receptor pore format endoplasm reticulum membran via n terminus thus activ endoplasm reticulum stress turn famb interact autophag protein lc thus induc cardiac autophagi promot cardiomyocyt apoptosi aggrav dic result suggest gsdmd promot autophagi induc cardiomyocyt apoptosi modul reaction famb lc therebi promot dic injuri target regul gsdmd may new target prevent treatment dic
|
D066126;D032383
|
T025;T037
|
36,289,190
|
oncoprotein muc facilit breast cancer progress promot pink depend mitophagi via atada destabil mitophagi vital process control mitochondria qualiti dysregul promot cancer oncoprotein mucin muc target mitochondria attenu drug induc apoptosi howev littl known whether muc contribut mitochondri homeostasi cancer cell identifi novel role muc promot mitophagi increas mitophagi coupl transloc muc mitochondria muc interact induc degrad atpas famili aaa domain contain atada result protect pten induc kinas pink atada mediat cleavag interest muc induc mitophagi associ increas oncogen cancer cell similar inhibit mitophagi signific suppress muc induc cancer cell activ vitro vivo consist muc atada protein level present invers relationship tumor tissu breast cancer patient data valid mucatadapink axi mediat mitophagi constitut novel mechan maintain malign cancer cell provid novel therapeut approach muc posit cancer
|
D001943;D063306
|
T191;T043
|
36,289,166
|
ecolog potenti assess land use area estim agricultur land base multi time imag sentinel use anp wlc gis bastam iran use land base ecolog potenti key manag factor achiev sustain develop conserv soil water resourc purpos studi use multi time imag sentinel determin area agricultur land evalu ecolog potenti bastam semnan provinc iran therefor first step common agricultur land includ apricot grape orchard field crop includ wheat forag maiz phenolog period determin inform classifi use name support vector machin maximum likelihood minimum distanc next step soil topographi climat data extract accord expert opinion analysi basin natur potenti ecolog evalu model region appli homogen unit calcul ecolog potenti index integr anp wlc model ecolog potenti map generat result land use classif show support vector machin model minimum distanc respect best worst perform kappa coeffici highest area cultiv land hectar estim wheat lowest hectar forag maiz moreov result ecolog potenti evalu show apricot orchard wheat field class good ecolog potenti overal hectar poor class hectar excel class term ecolog potenti
|
D040362;D009320
|
T123;T170;T073;T116
|
36,289,148
|
cacti low cost substrat produc l asparaginas endophyt fungi studi aim select endophyt fungi produc l asparaginas partial optimis product enzym use cacti substrat seventeen endophyt assess intracellular enzymat potenti modifi czapek dox medium use l prolin induc best produc evalu intracellular extracellular enzymat activ modifi czapek dox medium use flour opuntia ficus indica nopalea cochenillifera substrat biomass l asparaginas product profil analys best condit enzym product verifi use factori design penicillium decaturens urm diaporth ueckera urm colletotrichum annellatum urm produc u g u g u g l asparaginas respect diaporth ueckera urm produc intracellular l asparaginas use flour n cochenillifera u g ficus indica u g last select next step ideal time biomass l asparaginas product h best condit enzym product u g initi ph inoculum concentr cacti flour concentr observ increas compar initi product opuntia ficus indica flour indic altern low cost substrat product l asparaginas endophyt fungus ueckera urm
|
D001215;D029421
|
T121;T126;T116;T002
|
36,289,139
|
joint interact mutual understand social robot social robot aim design robot capabl joint interact human conceptu level suffici mutual understand usual said necessari condit joint interact background follow question remain open sens legitim speak human robot joint interact exact mean speak human robot suffici understand account human robot joint interact joint interact effect possibl refer eg mere ascript simul understand answer question first discuss technic approach aim implement certain aspect human human communic interact social robot order make robot access understand human henc human robot joint interact possibl second examin human tendenc anthropomorph context view human understand joint interact social robot third analyz promin concept mutual understand implic human robot joint interact conclud least time legitim speak human robot joint interact relev implic moral ethic
|
D012371
|
T090
|
36,289,136
|
nanoscal surfac rough induc poor solvent polym film surfac describ new nanoscal morpholog produc polym surfac expos poor solvent measur morpholog polystyren surfac exposur pentan heptan dodecan well poli methyl methacryl expos propanol methanol length scale morpholog determin analyz imag obtain atom forc microscopi case polystyren perform detail character morpholog solvent molecular weight valu formula see text rang kgmol compar result model dimpl morpholog dens graft chain suggest mechan respons
|
D011108;D011137
|
T104;T122;T109
|
36,289,122
|
isoflavon consumpt reduc inflamm modul phenylalanin lipid metabol phytoestrogen found soy fruit peanut legum identifi metabolit capabl provid benefici effect multipl patholog condit due abil mimic endogen estrogen interest health promot effect phytoestrogen isoflavon depend presenc specif gut bacteria specif gut bacteria metabol isoflavon equol higher affin endogen estrogen receptor compar dietari isoflavon previous shown patient multipl sclerosi ms neuroinflammatori diseas lack gut bacteria abl metabol phytoestrogen valid import isoflavon phytoestrogen metabol gut bacteria diseas protect util anim model ms specif shown isoflavon rich diet protect neuroinflammatori diseas protect depend abil gut bacteria metabol isoflavon equol addit mice diet isoflavon show anti inflammatori respons compar mice diet lack isoflavon howev unknown isoflavon andor equol mediat protect effect especi effect host metabolit level
|
D007529
|
T121;T109
|
36,289,116
|
gas liquid interfac lennard jone binari mixtur control differenti activ phase transit interfaci stabil perform molecular dynam simul two dimension binari mixtur lennard jone particl character degre activ insid start base state featur gas liquid interfac complet segreg system thermodynam equilibrium introduc differenti scalar activ two speci prescrib two differ effect temperatur differenti activ measur ratio two temperatur previous studi show segreg homogen mix system induc high activ studi investig effect activ pre exist gas liquid interfac two separ speci wherea high activ ratio induc format new interfac show low activ ratio destabil exist one moreov combin pre exist interfac differenti activ lead partial crystal thus tripl phase coexist solid liquid gas observ wide rang moder differenti activ find ideal system guid understand interfaci behavior certain biolog system
|
D056004
|
T066;T044
|
36,289,115
|
tn tn famili transposon encod putat iron uptak function found acinetobact acinetobact baumannii opportunist pathogen becom difficult erad main high level antibiot resist featur contribut organ success abil compet nutrient iron recent sever novel tn famili transposon encod synthesi transport siderophor iron uptak system characteris anoth tn type transposon name tn describ tn contain set iron utilis gene transposit modul relat tn tn famili transposon carri iron uptak system facilit spread function acinetobact strain given tn known transpos effici prefer target site find siderophor function tn famili transposon import context dissemin virul gene amongst acinetobact strain
|
D017262;D040981
|
T123;T007;T109
|
36,289,114
|
ontolog base studi water qualiti probabilist risk assess exposur fluorid nitrat shiraz drink water iran use fuzzi multi criteria group decis make model world health organ report million peopl die year insuffici sanitari drink water ontolog base studi focus investig chemic qualiti drink water new water qualiti index design fuzzi multi criteria group decis make method merg gis second survey non carcinogen risk assess fluorid nitrat use mont carlo simul sensit analysi shiraz water sourc f ec tds alkalin th cl na appli wqi mean concentr mgl cold warm season mean concentr fluorid mgl cold warm period th centil fluorid hqs among infant children teenag adult respect cold season respect mention group warm season comparison th centil nitrat hqs among infant children teenag adult respect hqs infant children teenag nitrat various advers effect wherea fluorid advers affect age group season also nitrat concentr increas non carcinogen risk ir ed lead hq increas contrast bw negat effect risk increas overal sourc manag paramet signific reduc concentr nitrat advers human health effect
|
D060587;D060766;D014874
|
T070;T082;T131;T081;T167
|
36,289,108
|
cytotox anti biofilm activ biogen cadmium nanoparticl cadmium nitrat preliminari studi wild type microorgan becom toler higher antibiot antimicrobi agent concentr due global increas antibiot consumpt green synthes nanoparticl nps propos potenti antimicrobi agent overcom problem research prepar cadmium nanoparticl cd nps use artemisia persica extract clarifi biolog behavior cd nps cd cytotox antibacteri anti biofilm biocompat experi perform sinc cd toxic associ liver kidney damag deficit hepg huvec cell line employ vitro cytotox model cd nps lower cytotox effect cd hepg huvec cell cd nps exhibit hemolysi activ antibacteri anti biofilm studi conduct use gram posit staphylococcus aureus gram negat proteus mirabili pseudomona aeruginosa abil form sever adher biofilm antibacteri activ cd nps clinic isol aureus p mirabili p aeruginosa g ml cd nps g ml decreas biofilm format aureus p mirabili p aeruginosa respectivelymoreov ad cd nps gdisc antibiot disc increas antibacteri activ vancomycin gentamicin tetracyclin streptomycin meropenem kanamycin methicillin resist aureus signific due emerg resist microorgan cd nps use excit materi counterattack global health problem research need clarifi molecular mechan under cd nps pharmacolog toxicolog effect
|
D055624;D053758;D000890;D053768
|
T121;T007;T073
|
36,289,095
|
zavot cattl genet character use microsatellit studi aim reveal genet divers phylogenet relationship intra inter breed zavot cattl rais local around kar provinc trkiy total zavot zav n eastern anatolian red ear n simment sim n brown swiss bs n holstein hol n non relat cattl without clinic health problem evalu use standard phenol chloroform method deoxyribonucl acid dna isol blood sampl amplifi multiplex polymeras chain reaction pcr use bovin specif microsatellit marker capillari electrophoresi process appli denatur pcr product total differ allel identifi averag averag effect allel accord genet distanc matrix popul largest genet distanc found zav hol popul zav ear popul locat root largest f st valu found among zav hol popul accord factori correspond analysi fca graph popul locat separ also show mixtur especi zav ear bs popul averag polymorph inform content pic valu lowest bm marker highest tgla marker conclus zav cattl bred kar region found complet separ bs sim breed claim contribut format zav breed sinc current nativ breed symbol region inbreed prevent increas studi devot protect breed establish pure herd use futur nativ cattl trkiy
|
D002725;D014644
|
T131;T070;T130;T109
|
36,289,094
|
feasibl studi lenvatinib plus pembrolizumab japanes patient advanc solid tumor combin treatment use lenvatinib multikinas inhibitor plus pembrolizumab program death immun checkpoint inhibitor shown efficaci treatment endometri renal cell cancer phase b studi investig toler safeti lenvatinib plus pembrolizumab japanes patient metastat select solid tumor
|
D002289;D008175;D002295;D007680
|
T191
|
36,288,995
|
earli stage contactin associ protein like limbic enceph clue diagnosi previous studi suggest autoimmun limbic enceph antibodi contactin associ protein like caspr enceph clinic heterogen progress slowli prevent earli recognit aim describ onset progress caspr enceph assess long term outcom
|
D020363;D007319;D004660;D009437
|
T184;T047;T048
|
36,288,931
|
qualit content analysi comment press articl deem consent organ donat canada two canadian provinc becam first jurisdict north america pass deem consent legisl increas deceas organ donat transplant rate sought explor perspect deem consent legisl organ donat canada viewpoint individu comment press articl
|
D009927;D016377
|
T061;T073;T055;T033;T058
|
36,288,901
|
actin bind domain rng spars bound f actin strong inhibit actin movement myosin ii report case sub stoichiometr bind actin bind protein profound structur function consequ provid insight fundament properti actin regul rng iqgap contain contractil ring fission yeast schizosaccharomyc pomb use high speed atom forc microscopi electron microscopi found sub stoichiometr bind calponin homolog actin bind domain rng rngchd induc global structur chang skelet muscl actin filament includ shorten filament helic pitch sub stoichiometr bind rngchd also reduc affin actin filament muscl myosin ii carri adp strong inhibit motil actin filament myosin ii vitro skelet muscl myosin ii coat surfac rngchd stop actin movement bind ratio rngchd also inhibit actin movement myosin ii amoeba dictyostelium case detach actin filament myosin ii coat surfac thus spars bound rngchd induc appar cooper structur chang actin filament inhibit forc generat actomyosin ii
|
D004023;D012568
|
T004;T204
|
36,288,898
|
activ vitamin c ovarian cancer cell enhanc hyperthermia vitamin c essenti proper function human bodi play crucial role mani biolog process cofactor enzym anticanc activ vitamin c indic year hyperthermia use clinic allow increas effect anticanc therapi may also use enhanc action substanc purpos studi enhanc anticanc activ vitamin c hyperthermia ovarian cancer cell
|
D010051;D000970;D006979
|
T061;T121;T191;T109
|
36,288,897
|
neoadjuv modifi short cours radiotherapi stage iv rectal cancer studi aim assess clinic outcom neoadjuv modifi short cours radiotherapi msc rt rectal metastat adenocarcinoma
|
D012004;D000230
|
T191
|
36,288,896
|
role matrix metallopeptidas genotyp taiwanes patient colorect cancer matrix metalloproteinas mmp report play critic role metastat behavior cancer via regul extracellular matrix howev genotyp seldom examin colorect cancer crc examin role mmp promot rs rs genotyp colorect cancer crc
|
D015179;D020778
|
T191;T126;T116
|
36,288,895
|
impact routin surveil imag recurr sinonas malign signific variat post treatment surveil imag sinonas malign studi examin util surveil imag detect recurr patient treat sinonas malign
|
D010255;D009669
|
T191
|
36,288,894
|
clinic signific earli recurr curat resect colorect cancer although surviv case earli recurr curat resect colorect cancer persist poor risk factor earli recurr remain unknown
|
D018395;D015179
|
T129;T191;T109
|
36,288,893
|
loss heterozygos brca predict marker talazoparib respons tumor cell line essenti tool understand molecular mechan under cancer biolog therapeut respons poli adp ribos polymeras inhibitor parpi kill tumor cell harbor pathogen mutat brca dna repair associ gene brca approv treat ovarian metastat breast cancer loss heterozygos loh wild type brca locus suspect increas cellular respons parpi better elucid molecular mechan under parpi sensit resist studi assess respons various pathogen brca mutant cell line parpi talazoparib
|
D012266;D001943
|
T191;T109
|
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