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biomedical-topic-categorization-validation

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36,288,707
gm csf tc cell requir bolster vaccin immun lethal fungal pneumonia without caus overt patholog gm csf co express cell instig patholog inflamm autoimmun disord function immun infect unclear demonstr role gm csf tc cell vaccin immun lethal fungal pneumonia cytokin requir induct memori homeostasi vaccin induc gm csf tc cell necessari bolster pulmonari fungal immun without inflat patholog although gm csf express tc cell preferenti elev memori phase phenotyp attribut strong suggest like tc cell ifn produc tc cell il il gm csf necessari elicit gm csf tc cell follow vaccin il dispens memori tc gm csf tc cell mainten recal respons effector memori tc cell lung requir studi reveal benefici nonpatholog role gm csf tc cell fungal vaccin immun
D011014;D014612
T129;T121;T050;T116;T047
36,288,706
structur basi interleukin b receptor complex neutral antibodi guid human affin matur upregul interleukin receptor b il rb known oncogen il receptor ligand general involv pro inflammatori pathway identifi mous neutral monoclon antibodi mab block il rbil b pathway inhibit pancreat tumorigenesi orthotop mous model x ray crystal structur il rb ectodomain complex neutral antibodi show bind predict ligand bind interfac engag loop il rb fibronectin iii domain uniqu conform state structur also provid import paratop inform guid design antibodi human affin matur result human b antibodi margin affin loss effect neutral il bil rb signal imped tumorigenesi mous xenograft model
D053722;D020381
T129;T123;T116;T192
36,288,705
otub exert tumor suppress role via stat mediat calml activ increas phosphatidylserin synthesi oral esophag squamous cell carcinoma sccs associ high mortal yet molecular mechan under malign larg unclear show dna hypermethyl otubain otub previous recogn oncogen drive tongu esophag scc initi drug resist mechanist otub promot deubiquitin phosphoryl signal transduc activ transcript stat subsequ regul transcript calmodulin like protein calml activ calml mediat mitochondri calcium signal promot oxid phosphoryl oxpho synthesi phosphatidylserin ps mous model oral administ soybean deriv ps inhibit scc initi cell low otub express increas sensit chemotherapi studi indic otubstatcalmlp axi play tumor suppress role show potenti ps administr strategi treatment prevent tongu esophag sccs
D002147;D010718
T123;T116;T109
36,288,704
gasdermin restrict anti tumor immun pd l checkpoint blockad tumor microenviron tmes requir co oper innat adapt immun cell influenc tumor progress immunotherapi caspas activ gasdermin facilit tumor death promot anti tumor immun pyroptosi immun cell affect tme remain unclear tme express gasdermin gsdmd high express antigen present cell apc correl immun checkpoint signatur condit delet gsdmd demonstr gsdmd tme apc restrict anti tumor immun pd l inhibit loss gsdmd apc enhanc interferon stimul gene isg therebi promot cd cell activ cgas depend manner moreov pharmacolog inhibit gsdmd mediat pyroptosi pd l improv anti tumor immun highlight potenti combin gsdmdpd l inhibit immunotherapi therapeut strategi
D060890;D059016
T129;T070;T116
36,288,703
focus b cell respons recur gluten motif implic epitop spread celiac diseas antibodi deamid gluten peptid accur diagnost marker celiac diseas howev bind patient antibodi possibl gluten epitop previous investig assess serum antibodi specif across gluten proteom use high densiti peptid array confirm import deamid antibodi bind show respons remark focus known epitop qpeqpfp e result deamid q addit describ epitop nativ non deamid gluten qqpeqii e gene encod associ b cell cell reactiv antibodi nativ epitop cross reactiv major deamid epitop due recognit share peq motif sinc cross reactiv b cell present peptid differ gluten specif cell propos b cell play role epitop spread engag cell multipl specif
D002446;D005983
T123;T047;T116
36,288,702
bacteri argonaut effici dna rna cleavag activ guid small dna rna argonaut protein widespread prokaryot eukaryot diversifi catalyt activ describ argonaut marinitoga hydrogenitoleran mhago eight cleavag activ util four type guid effici cleavag singl strand dna ssdna rna target reveal prefer terminus nucleotid p guid obvious prefer oh guid uncov moreov cleavag effici heavili impair mismatch central supplementari region guid affin guid guidestarget duplex mhago prove one factor affect cleavag effici structur mutat analys impli unknown distinct structur featur behind cleavag activ mhago meanwhil oh guid rna grna mediat plasmid cleavag activ unveil conclus mhago versatil biochem characterist improv understand pago pago base techniqu
D060565;D017394
T123;T116;T114
36,288,701
kcc drive chlorid microdomain format dendrit bleb intracellular chlorid ion concentr cl homeostasi critic excitatoryinhibitori balanc volum regul neuron quantit map spatiotempor dendrit cl dynam n methyl aspart nmda excitotox determin cl chang contribut local dendrit swell bleb stroke like condit whole cell patch clamp electrophysiolog combin simultan fluoresc lifetim imag flim cl dye n ethoxycarbonylmethyl methoxyquinolinium bromid mqae mqae flim reliabl report rest dynam cl shift dendrit nmda applic generat spatial restrict persist high cl subdomain dendrit bleb process requir ca influx subsequ open small conduct ca activ k sk channel propos sustain local k efflux increas extracellular k concentr k suffici discret region revers k cl cotransport kcc transport trigger synapt swell togeth data establish mechan kcc generat patholog cl microdomain bleb relev multipl neurolog disord
D002712;D027981
T123;T196;T034;T116
36,288,700
multienzym nitrosyl cascad regul cholesterol homeostasi accumul evid suggest protein nitrosyl enzymat regul specif nitrosyl deriv dedic nitrosylas denitrosylas conjug remov nitrosothiol respect report mice defici protein denitrosylas scor nitroso coenzym reductas akra exhibit mark reduct serum cholesterol due reduc secret cholesterol regul protein pcsk scor associ endoplasm reticulum er secretori machineri control nitrosyl cascad involv er cargo select protein sar surf moonlight nitrosylas sar act surf nitrosylas surf pcsk nitrosylas inhibit pcsk secret scor counteract nitrosylas activ promot pcsk denitrosyl inhibit pcsk base drug requir nitrosylas activ small molecul inhibit scor phenocopi pcsk mediat reduct cholesterol observ scor defici mice result reveal enzymat machineri control cholesterol level nitrosyl suggest distinct treatment paradigm cardiovascular diseas
D000071449;D026403
T123;T121;T116;T109;T126
36,288,699
phosphoryl dna repair scaffold slx drive fold sap domain activ mus eme endonucleas dna repair scaffold slx multifacet role genom stabil mani depend structur select endonucleas slx coordin cell cycl regul assembl slx mus eme xpf ercc tri nucleas complex call smx mechanist mitot kinas cdk regul interact slx mus eme remain unclear show cdk cyclin b phosphoryl slx residu mus bind region slx mbr phosphoryl slx mbr relax substrat specif mus eme stimul cleavag replic recombin structur provid biochem explan chromosom pulver occur slx bind mus phase remark phosphoryl slx mbr drive fold sap domain underpin high affin interact mus also report structur phosphoryl slx mbr identifi mus bind interfac work provid mechanist insight cell cycl regul phosphoryl slx drive recruit activ mus eme
D004720;D045522
T126;T116
36,288,698
yeast smi human homolog gigyf regul cdcvcp function transcript stress last resort pathway result ubiquityl degrad rna polymeras ii respons transcript stress govern factor def yeast show smi gene act multi copi suppressor def delet function multipl step last resort pathway also provid genet biochem evid dispar cellular process smi work broad hitherto overlook regul cdc function similar smi homolog gigyf affect transcript stress respons human cell regul function cdc homolog vcpp present explor target cancer therapi inde show apoptosi induc effect vcp inhibitor nms cb gigyf depend
D012441;D029701
T004;T116
36,288,697
microgli nlrp inflammasom activ neurotox astrocyt depress like mice function regul differ heterogen reactiv state astrocyt depress remain unclear demonstr neurotox reactiv like astrocyt strong induc prior behavior impair dendrit atrophi depress like mice interest global microglia specif knockout nod like receptor protein nlrp mark mitig like astrocyt induct wherea astrocyt specif nlrp deplet ineffect microgli nlrp ablat also allevi neuron dysfunct induc like astrocyt vitro vivo show microglia nf b pathway activ nlrp inflammasom turn activ caspas induc secret inductor lead product like astrocyt altogeth studi reveal function microgli nlrp inflammasom induct neurotox astrocyt via activ neuroinflammatori caspas pathway respons chronic stress suggest potenti therapeut strategi depress
D058847;D020258
T123;T116;T037
36,288,696
nkt cell adopt glutamin addict phenotyp regul homeostasi function natur killer nkt cell oper distinct differ metabol program cd cell includ strict requir glutamin regul cell homeostasi howev under mechan remain unknown report steadi state nkt cell higher glutamin level cd cell nkt cell increas glutaminolysi activ activ nkt cell use glutamin fuel tricarboxyl acid cycl glutathion synthesi addit glutamin deriv nitrogen enabl protein glycosyl via hexosamin biosynthesi pathway hbp branch glutamin metabol seem critic nkt cell homeostasi mitochondri function glutaminolysi hbp differenti regul interleukin il interferon ifn product glutamin metabol appear control amp activ protein kinas ampk mammalian target rapamycin complex mtorc signal find highlight distinct metabol requir nkt cell compar cd cell may therapeut implic treatment certain nutrient restrict diseas
D055611
T025
36,288,695
trna methyl resolv codon usag bias limit cell viabil codon usag genom close correl abund trna isoacceptor codon usag bias resolv trna post transcript modif larg unknown demonstr n methyl guanosin posit g side anticodon direct respons read codon neutral resolv differenti decod prolin codon genom wide suppressor screen non viabl escherichia coli strain lack g identifi pros suppressor mutat indic coupl methyl trna prolyl aminoacyl set limit cell viabil use suppressor prolyl aminoacyl decoupl trna methyl show g neutral differenti translat prolin codon major isoacceptor lack g inactiv neutral expos need minor isoacceptor cell viabil work medic implic bacteri speci exclus use major isoacceptor surviv
D000926;D000081183
T045;T123;T114
36,288,694
dna doubl strand break deriv rna drive tirrbp complex dissoci tudor interact repair regul tirr rna bind protein negat regul dna repair factor p bind protein bp non damag condit tirr bound bp dna damag tirr bp dissoci bp bind chromatin doubl strand break dsb promot non homolog end join nhej mediat repair howev exact mechanist detail dissoci damag unknown increas evid implic rna crucial factor dna damag respons ddr show rna separ tirrbp specif rna hairpin secondari structur transcrib dsb rna polymeras ii rnapii promot tirrbp complex separ hairpin rna bind residu tirr bp result uncov role dna damag deriv rna modul protein protein interact contribut understand dsb repair
D053903;D012313
T049;T114
36,288,693
de novo establish circuit modul restor locomot spinal cord injuri adult zebrafish mechan under spontan locomotor recoveri spinal cord injuri sci remain unclear use adult zebrafish complet sci show va interneuron regrow axon bridg lesion spinal segment subclass specif chronolog order earli sci reestablish unitari high rhythm locomotor circuit driven mere axon regrown fast va interneuron later reestablish intraspin de novo circuit organ modular design axon regrown fast slow va interneuron rostral lesion select drive caudal fast vamotor neuron slow vamotor neuron respect order circuitri reestablish determin stepwis restor locomotor repertoir recapitul development process progress interrupt ablat calretinin fast modul relat protein acceler physic train find suggest promot axon regrowth propriospin va interneuron establish de novo intraspin circuit underpin effect physic train patient sci
D015027;D013119
T037;T013
36,288,692
circadian transcript pathway atlas highlight proteasom switch intermitt fast intermitt fast safe strategi benefit health remain unclear whether timer exist vivo record fast durat trigger transcript switch map circadian transcript pathway atlas sampl across four metabol tissu mice five feed regimen result show detect canon pathway rhythmic tissu specif feed regimen specif manner less induc chang transcript function fast h initi circadian reson pathway liver reson punctual switch follow refeed hepat proteasom coordin reson gene encod proteasom subunit display h fast depend transcript switch find indic hepat proteasom may serv fast timer coordin pathway transcript reson provid target reveal under mechan intermitt fast
D005215;D057906
T033;T055;T040
36,288,691
crystal structur function analysi znf wwe wwe region parpzap defin distinct mode engag poli adp ribos parpzap zinc finger antivir protein act multipl virus promot degrad viral mrna parp four n termin zinc zn finger bind cg rich nucleotid sequenc c termin adp ribosyltransferas fold central region fifth zn finger tandem wwe domain central parp region znf wwe wwe implic bind poli adp ribos howev limit insight structur function present crystal structur znf wwe wwe mous parp complex adp ribos complex atp crystal structur bind studi demonstr wwe interact adp ribos atp wherea wwe function bind site bind studi poli adp ribos ligand indic wwe serv anchor preferenti bind termin end poli adp ribos chain composit znf wwe wwe structur form extend surfac engag adp ribos chain repres distinct mode recognit provid framework investig impact poli adp ribos parp function
D011064;D000246
T123;T114
36,288,690
activ toll like receptor ebola virus shed glycoprotein direct requir intern fusion loop glycosyl infect ebola virus member filovirida famili rna virus lead acut viral hemorrhag fever end stage ebola virus diseas character cytokin storm caus tissu damag vascular disintegr multi organ failur previous studi show shed form viral spike glycoprotein sgp drive hyperinflammatori respons activ toll like receptor tlr find glycosyl requir activ tlr sgp identifi intern fusion loop ifl essenti inflammatori signal sgp compet lipid antagonist tlr ifl interact direct tlr co receptor md togeth find indic sgp activ tlr analog bacteri agonist lipopolysaccharid lps bind hydrophob pocket md promot format activ heterotetram conclus support dock studi predict bind site sgp tlr md
D029043;D019142
T005;T047
36,288,678
mechan properti young mice tibia four circumferenti quadrant nanoindent character mechan properti differ anatom quadrant bone conduct literatur help understand correl among bone morphometr densitometr materi properti howev although data compar four quadrant long bone adult limit research young adult especi young femal henc nine tibia mid shaft specimen harvest nine week old cblj femal mice rough correspond age rang juvenil young adult one left tibia harvest one anim total indent test perform four indent per quadrant nine tibia specimen divid four quadrant oliv pharr method use calcul indent modulus hard one way anova kruskal walli nonparametr test use studi influenc differ anatom quadrant indent modulus hard result show indent modulus week old mous tibia shaft gpa hard gpa influenc circumferenti anatom quadrant tibial shaft indent modulus p hard p statist signific method result could potenti help studi treatment young femal long bone comprehens understand effect treatment four quadrant consid collagen fiber degre miner chang collagen cross link high resolut nanoindent
D013977;D018483
T023
36,288,667
discoveri novel dihydropyrazol stilben deriv amelior heart failur modul pnf b signal pathway heart failur one diseas highest mortal world inflamm main caus occurr develop stilben skeleton resveratrol shown excel anti inflammatori antioxid activ order continu research dihydropyrazol deriv seri novel e methyl phenyl styrylphenyl dihydro h pyrazol yl thiazol deriv design synthes accord principl molecular hybrid evalu anti inflammatori antioxid activ screen anti inflammatori abil raw cell analyz preliminari structur activ relationship explor relat molecular mechan use doxorubicin dox induc heart failur model explor protect role compound vivo result show compound f exhibit potent activ superior posit control revers express lipopolysaccharid lps regul induc nitric oxid synthas ino cyclooxygenas cox tumor necrosi factor tnf interleukin il superoxid dismutas sod raw cell addit compound f also inhibit dox induc inflamm reactiv oxygen speci modul pnuclear factor kappa b nf b signal pathway hc cell vivo result show compound f amelior dox caus damag reduc left ventricular eject fraction sever inflamm fibrosi oxid stress heart conclus compound f could use promis agent treatment heart failur attenu oxid stress inflamm
D013267;D006333
T047;T046;T109
36,288,666
temperatur respons aquat greenhous gas emiss differ domin plant type greenhous gas ghg emiss small inland water disproportion larg climat warm expect favor domin alga free float plant expens submerg plant differ rout function plant type may far reach impact freshwat ghg emiss futur warmer water yet unknown conduct l mesocosm experi test effect plant type warm ghg emiss temper inland water domin either alga free float submerg plant control warm c treatment one year result show effect experiment warm ghg flux differ domin differ function plant type main modul methan ebullit often domin ghg emiss pathway specif demonstr respons experiment warm strongest free float lowest submerg plant domin system import result suggest anticip shift plant type submerg plant domin alga free float plant warm may increas total ghg emiss shallow water togeth warm induc emiss respons repres far overlook posit climat feedback manag strategi aim favour submerg plant domin may thus substanti mitig ghg emiss
D000074382
T197
36,288,665
fate microplast estuari quantit simul approach microplast pollut emerg environment concern howev almost mps numer simul studi yangtz estuari consid largest plastic export world quantit simul carri exist model therefor complet quantit simul explor differ pattern mps transport main object studi addit concentr distribut risk mps also analyz mass number method propos quantit simul microplast concentr feb may error less compar sediment floccul settl transport independ float transport suscept surfac current result increas beach inhomogen concentr distribut meanwhil influenc current local topographi salt wedg mps perform linear motion clockwis spiral motion insid outsid estuari rapid form hot spot southeastern part chongm island mps beach settl insid estuari especi north shore therefor mps risk sensit target concern accord risk assess result result break space time limit explor fate mps yangtz estuari provid new idea concern mps numer simul
D000080545;D014874
T131;T122
36,288,664
aquat photolysi pharmaceut ambroxol role dibromoanilin chromophor heavi atom effect bromin one effect expector class drug ambroxol amb frequent use treat acut chronic bronchiti extens use human excret result widespread occurr amb wastewat herein report photolysi amb aqueous solut upon nm ultraviolet radiat uv spectroscop character show dibromoanilin dba moieti core chromophor amb quantum yield dba chang littl ph howev amb show higher quantum yield ph dba amb high photoreact attribut heavi atom effect bromin substitu photolysi amb occur photoreduct photoion photonucleophil substitut side chain cleavag coupl reaction amb dba underw debromin yield reach mj cm uv fluenc photo debromin occur preferenti para posit presenc natur organ matter inhibit photodegrad main due light screen effect photolysi amb slight enhanc presenc like due radic induc oxid bioluminesc inhibit assay reveal photoproduct toxic result show uv radiat fluenc relev advanc oxid process effect abat amb wastewat howev uv treatment wastewat contain higher concentr g l amb done caution releas br convert toxic bromin disinfect byproduct bromat subsequ oxid process
D000551;D014874
T121;T131;T109
36,288,663
use pilot scale geomedia amend biofiltr system remov polar trace organ inorgan contamin stormwat runoff stormwat runoff captur groundwat recharg provid sustain mean augment local water resourc water stress citi simultan mitig flood risk provid process compromis groundwat qualiti develop test one year innov pilot scale stormwat treatment train employ cost effect engin geomedia continu flow unit process system remov contamin urban runoff aquif recharg system consist iron enhanc sand filter phosphat remov woodchip bioreactor nitrat remov coupl aerat step column pack differ configur biochar manganes oxid contain sand remov trace metal persist mobil toxic trace organ contamin condit authent stormwat runoff extend period month woodchip bioreactor remov influent nitrat g n phosphat broke iron enhanc sand filter challeng test month geomedia remov mass metal trace organ compound column hydraul perform stabl entir studi weather biochar manganes oxid effect remov trace organ contamin metal respect condit like encount field sustain nutrient remov probabl polar organ compound could breakthrough decad condit studi site
D018508
T052;T057
36,288,633
trim promot ovarian cancer cell prolifer migrat invas activ stat signal tripartit motif trim protein play promin role mani cancer studi aim investig biolog role trim ovarian cancer
D010051
T191
36,288,632
target massiv parallel sequenc panel diagnos genet endocrin disord tertiari hospit analyz effici multigen target massiv parallel sequenc panel relat endocrin disord molecular diagnosi patient assist tertiari hospit involv train medic faculti
D059014
T063;T059
36,288,629
inject multifunct thermo sensit chitosan base hydrogel periodont therapi bacteria recogn drive factor periodont howev excess reactiv oxygen speci ros harm periodont tissu also caus uncontrol inflammatori respons henc elimin excess ros block ros induc abnorm inflammatori respons antioxid achiev remark result periodont therapi moreov influenc deep irregular periodont pocket inject thermo sensit chitosan base hydrogel attract lot attent studi aim formul antibacteri antioxid therapeut regimen incorpor antimicrobi peptid nal p andor antioxid polydopamin nanoparticl pdnps chitosan base hydrogel hydrogel character vitro final examin rat use experiment periodont model releas kinet show hydrogel could stabli releas nal p pdnps day scaveng activ hydrogel dpph antibacteri ratio streptococcus gordonii gordonii fusobacterium nucleatum f nucleatum porphyromona gingivali p gingivali import examin hydrogel abil prevent periodont tissu damag thus chitosan base hydrogel may provid basi design multifunct local drug deliveri biomateri treatment periodont
D048271;D010518
T121;T047;T109
36,288,625
simpl fast determin tetrodotoxin human plasma base hydrophil interactionion exchang mix mode solid phase extract combin liquid chromatographi tandem mass spectroscopi studi develop valid simpl fast sensit lc msms method measur tetrodotoxin ttx human plasma three hilic type solid phase extract spe carrier psa silica siphila hilix differ stationari phase function group compar siphila hilix spe plate contain multi carboxyl group final select due obvious better extract recoveri ttx recoveri plasma sampl two signific matrix effect observ specul mix mode synergist effect hydrophil interact ion exchang l plasma sampl precipit rapid acetonitril contain trichloroacet acid filtrat load onto siphila hilix well spe plate wash acetonitril ttx elut l acetonitril contain trichloroacet acid l elut solut direct inject lc msms total run time beh amid column min method avoid evapor ultrafiltr process simpl timesav ngml intra inter assay accuraci rang relat standard deviat rsds rsds respect bias spike analysi rang healthi human plasma sampl rsds hemolyt high triglycerid high cholesterol high bilirubin plasma sampl rsds prove good anti interfer properti method result show method sensit accur specif reliabl use monitor concentr ttx plasma meet need clinic research poison screen
D053719;D014238
T063;T121;T131;T109
36,288,624
quecher base extract two dimension liquid chromatographi high resolut mass spectrometri determin long chain chlorin paraffin sediment studi method establish analysi long chain chlorin paraffin lccps sediment base quick easi cheap effect rug safe quecher extract two dimension liquid chromatographi orbitrap high resolut mass spectrometri dlcorbitrap hrms compar report method method great reduc sampl prepar time h solvent consumpt quecher extract method present satisfactori recoveri ngg lccps cl spike sediment meanwhil matrix effect found lccps analysi onlin purif dlc system current commerci lccp standard mixtur three chlorin paraffin cps industri product suspect screen strategi establish accur identif lccps includ vlccps carbon chain length greater plight refer standard vlccps current unavail total c lccp vlccp congen identifi sediment sampl collect dongt lake china total concentr lccps six sediment sampl rang ngg median ngg domin c group mean c group mean c group mean taken togeth success applic method analyz sediment sampl show great potenti analysi lccps environment sampl futur studi
D010232;D006843
T121;T073;T109
36,288,623
identif monoclon antibodi clip variant cross valid use capillari electrophoresi sodium dodecyl sulfat capillari zone electrophoresi mass spectrometri capillari isoelectr focus mass spectrometri critic qualiti attribut cqas recombin monoclon antibodi therapeut constant monitor throughout life cycl drug develop manufactur past decad numer analyt techniqu develop character cqas regard non reduc reduc capillari electrophoresi sodium dodecyl sulfat ce sds method wide adopt biopharmaceut industri evalu size relat heterogen biolog work demonstr recent develop capillari electrophoresi mass spectrometri ce ms technolog clip variant bevacizumab may identifi direct capillari zone electrophoresi mass spectrometri cze ms capillari isoelectr focus mass spectrometri cief ms approach provid power addit tradit ce sds analysi workflow novel workflow linear regress mobil molecular weight first result approxim size rang variant intact mass speci bevacizumab obtain deconvolut featur identifi cze ms analysi subsequ cze ms analysi subunit bevacizumab lead confirm clip heavi chain furthermor cief ms intact bevacizumab confirm exist clip variant cross valid ce sds cze ms cief ms creat comprehens roadmap monoclon antibodi size variant profil ce base analyt techniqu complementari lead orthogon verif size heterogen character
D000911;D001688
T129;T121;T123;T116
36,288,622
planar chromatographi bioassay parallel sensit detect androgen anti androgen cytotox anti androgen enter aquat environ eg effluent wastewat treatment plant agricultur set contribut endocrin disrupt wildlif human due simultan presenc agonist compound common vitro bioassay underestim risk pose androgen antagonist hand cytotox effect might lead fals posit assess anti androgen effect convent bioassay present studi combin normal phase high perform thin layer chromatographi np hptlc yeast base report gene assay establish detect anti androgen promis tool reduc interfer androgen anti androgen compound present sampl avoid misinterpret anti androgen cytotox effect cell viabil assess parallel plate use resazurin viabil assay adapt hptlc plate method character establish dose respons curv model compound flutamid bisphenol calcul effect dose ed ng zone flutamid ng zone bisphenol success distinct anti androgen cytotox exemplarili demonstr nitroquinolin oxid proof concept detect quantif anti androgen extract landfil leachat demonstr studi show hyphen hptlc yeast anti androgen screen matrix robust cost effici fast screen tool sensit simultan detect anti androgen cytotox effect environment sampl method offer wide rang possibl applic environment monitor contribut identif anti androgen driver cours effect direct analysi
D000728;D000726
T125;T121;T039
36,288,621
multimod imag multifoc choroid adapt optic ophthalmoscopi describ longitudin anatom function alter caus inflammatori neovascular lesion idiopath multifoc choroiditispunct inner choroidopathi use adapt optic imag microperimetri
D007208;D002833
T047;T130;T109
36,288,620
invent cyanoacryl retinopexi st centuri literatur review case seri report use cyanoacryl n butyl cyanoacryl previous fail retin reattach surgeri chorio retin coloboma report surgic techniqu challeng long term outcom three patient underw surgeri
D012163;D003103;D004659;D012167
T121;T109;T122;T019;T047
36,288,619
danon diseas model photoreceptor degener secondari primari retin pigment epithelium diseas describ detail retin phenotyp lamp associ danon diseas
D015794;D052120;D012162
T047;T046
36,288,602
pediatr hip diseas increas risk opioid use adulthood long term burden pain depress legg calv perth diseas lcpd slip capit femor epiphysi scfe result pain deform hip joint impair rang motion earli develop secondari osteoarthr investig whether lcpd scfe associ increas use pain antidepress drug prescript later life
D007873;D060048;D009293
T047;T048
36,288,601
exercis facilit polar microglia enhanc autophagi via bdnfaktmtor pathway neuropath pain neuropath pain follow peripher nerv injuri microglia rapid activ accumul spinal cord physic exercis allevi neuropath pain howev exact mechan under analges effect fulli understood
D059348;D009437
T184;T047;T037
36,288,600
radiofrequ treatment iliac paravertebr cluneal nerv low back pain paravertebr cluneal nerv constrain within tunnel consist thoracolumbar fascia iliac crest superior rim pass iliac crest involv low back pain present previous
D017116;D012585
T184;T047
36,288,599
long term outcom puls radiofrequ supraorbit neuralgia retrospect multicentr studi puls radiofrequ prf percutan micro invas micro destruct neuromodul technolog report use treatment supraorbit neuralgia sn howev long term effect safeti techniqu sn report yet
D061208;D009437;D014277
T061;T184;T047
36,288,598
non invas pelvic floor rehabilit cancer popul incomplet cohort pelvic floor dysfunct associ symptom common clinic challeng cancer popul despit noninvas natur pelvic floor rehabilit pfr condit promis clinic result observ use pfr appear underus therapi
D009369;D053610
T121;T191;T131;T109
36,288,597
influenc handgrip strength psoa muscl index analges efficaci epidur steroid inject patient degen lumbar spinal diseas handgrip strength hgs psoa muscl index pmi wide use protocol screen diagnos sarcopenia measur muscl strength mass epidur steroid inject esi common intervent treatment spinal pain howev influenc pre procedur sarcopen status therapeut effect esi investig
D013130;D055948;D013122
T047;T020
36,288,596
comparison effect balloon cathet vs nucleoplasti vs balloon cathet nucleoplasti patient lumbar spinal stenosi nucleoplasti neuroplasti often perform patient refractori lower back pain conserv treatment ineffect lumbar spinal stenosi lss caus multipl factor case singl procedur nucleoplasti neuroplasti alon provid suffici treatment effect
D013130
T020
36,288,595
efficaci nucleoplasti radiculopathi caus foramin cervic disc herniat clinic result case seri technic note percutan cervic nucleoplasti pcn minim invas techniqu use treatment cervic disc herniat howev lesion locat neural foramen complet access effect neural decompress often challeng special anatom condit uncovertebr joint osteophyt facet joint cervic foramin space
D007405;D011843;D017587
T061;T047;T037
36,288,594
comparison pain reduct chang serum cortisol glucos level differ dose lumbar epidur dexamethason prospect studi lumbar epidur steroid inject lesi effect treatment low back pain howev may result increas blood glucos level decreas plasma cortisol concentr suppress adrenocorticotrop hormon axi
D017116
T184;T047
36,288,593
chang temperatur follow radiofrequ thermal ablat nucleus pulposus annulus fibrosus cadaver studi various minim invas procedur treat discogen pain report recent year disc fx system use perform nucleus pulposus np remov radiofrequ ablat annuloplasti guidanc x ray fluoroscopi howev probe tip focus heat place intradiscalsubannular area perform nucleo annuloplasti use radiofrequ lesion thermal injuri spinal cord spinal nerv concern
D000070616;D000070614;D007403;D017115
T061;T023
36,288,592
comparison two punctur approach ct guid percutan radiofrequ ablat stylomastoid foramen treatment hemifaci spasm hemifaci spasm hfs main character paroxysm involuntari twitch one side facial muscl develop awak ct guid percutan punctur stylomastoid foramen radiofrequ ablat rfa therapi treatment hemifaci spasm success use clinic
D019569;D005158;D000078703
T033;T184;T047;T061
36,288,591
analysi hemodynam respons radiofrequ thermocoagul trigemin neuralgia radiofrequ thermocoagul rft trigemin ganglion excel treatment option medic intract trigemin neuralgia howev procedur manifest abrupt chang cardiovascular respons abrupt cardiovascular chang sudden trigeminocardiac reflex occur rft trigemin ganglion
D014277
T047
36,288,590
effect repeat high voltag long durat puls radiofrequ herpet neuralgia puls radiofrequ prf common use minim invas method treat herp zoster neuralgia intens standard voltag prf limit result patient get last therapeut effect therapeut effect repeat high voltag long durat prf acut herp zoster neuralgia studi
D051474;D061208;D009437;D006562
T061;T184;T047
36,288,589
clinic radiolog risk factor earli recurr lumbar disc herniat six month less clinic retrospect analysi one medic center recurr ldh rldh one common caus unsatisfactori outcom discectomi usual need secondari surgeri lead physic psycholog suffer patient substanti cost societi
D007405;D017587
T061;T047
36,288,588
clinic outcom percutan endoscop lumbar discectomi assist sequenti snrb treat lumbosacr contigu doubl level disc herniat patient lumbosacr contigu doubl level disc herniat consensus level treat select nerv root block snrb identifi pain generat nerv root howev diagnost accuraci remain controversi due potenti spread inject sequenti snrb l may improv diagnost specif
D017587;D007405
T061;T047
36,288,587
cross section studi social media presenc acgm accredit pain medicin fellowship program time get onlin approxim american use social media platform use specif platform instagram twitter snapchat tiktok especi common among adult presenc social media account among resid fellowship program academ medicin use connect specialti highlight achiev research dissemin inform general public recruit tool applic
D061108;D000086382;D007396
T067;T170;T097;T065;T047
36,288,586
effect hypovitaminosi preoper pain threshold periop opioid use colorect cancer surgeri cohort studi postop pain colorect cancer surgeri signific impact postop physic mental health vitamin defici correl acut pain state includ postop post traumat pain sever chronic pain diseas effect hypovitaminosi preoper pain threshold periop opioid use colorect cancer surgeri still need studi
D014808;D009293;D015179
T047;T191;T048
36,288,585
effect ultrasound guid bilater erector spina plane block without dexmedetomidin intraop postop pain laparoscop cholecystectomi random control doubl blind prospect trial laparoscop cholecystectomi common surgic procedur perform western world perform minim invas procedur patient often complain moder sever postop pain role anesthesiologist effect manag remain crucial modern anesthesiolog practic embrac trunk block contribut periop multimod analgesia emerg literatur favor effect erector spina plane block reduct pain laparoscop cholecystectomi
D017081;D009407;D020927
T061;T121;T109
36,288,584
pediatr postop pain control quadratus lumborum block dexamethason two rout bupivacain prospect random control clinic trial ultrasound guid quadratus lumborum block qlb region analgesia approach report provid effect post oper pain relief abdomin retroperiton surgeri bupivacain often use well document local anesthet medic children dexamethason system glucocorticoid often use minim postop nausea vomit pain improv recoveri qualiti surgeri
D002045;D000779
T121;T109
36,288,583
ultrasound guid erector spina block versus ultrasound guid thorac paravertebr block pain relief patient acut thorac herp zoster random control trial sever acut pain signific risk factor postherpet neuralgia phn import earli manag allevi zoster pain overst
D059787;D009407;D051474;D006562
T061;T184;T047
36,288,582
comparison intravascular uptak technic eas anteroposterior obliqu view lumbar medial branch block inadvert intravascular inject local anesthet lead fals negat result follow lumbar medial branch block mbb perform diagnos facet joint origin pain previous studi demonstr type approach method could affect incid intravascular inject technic eas procedur
D009407;D021801
T061;T030
36,288,581
nurs support web base cognit behavior therapi chronic musculoskelet pain random control trial web base cognit behavior therapi cbt increas access effect pain manag though efficaci web base face face cbt may compar fewer studi examin whether remot clinic support addit web base cbt improv pain relat outcom
D059352;D015928;D059350
T033;T184;T047;T061
36,288,580
current understand phantom pain treatment phantom limb pain plp defin pain sensat portion bodi amput occur upward limb ampute signific impact patient qualiti life first hypothes diseas poor understood much time still today exact etiolog condit yet elucid peripheri plp resembl neuron chang seen neuropath pain condit howev central nervous system cns imag studi suggest chang uniqu plp cortic reorgan despit grow understand underpin mechan base treatment yet avail rather plethora treatment methodolog avail vari level support evid mani treatment util base efficaci seen non plp patient
D010591;D000674;D062187
T061;T047;T101
36,288,579
efficaci scrambler therapi manag chronic pain meta analysi random control trial although sever random control trial rcts report efficaci scrambler therapi st manag chronic pain find remain inconsist
D059350
T184;T047
36,288,578
comparison various region analgesia method postop analges effect video assist thoracoscop surgeri systemat review network meta analysi optim analgesia video assist thoracoscop surgeri vat still unknown
D020775;D015360
T061
36,288,577
compar systemat review meta analysi cochran review epidur inject lumbar radiculopathi sciatica epidur inject among common perform procedur manag low back lower extrem pain pinto et al chou et al previous perform systemat review meta analys along recent updat oliveira et al show lack effect epidur steroid inject manag lumbar disc herniat spinal stenosi radiculopathi contrast paper multipl systemat review meta analys support effect use epidur inject util fluoroscop guid techniqu major flaw review relat attribut activ control trial placebo control trial assumpt local anesthet provid sustain benefit despit extens evid local anesthet provid long term relief similar combin local anesthet steroid flaw
D011843;D012585;D017116
T184;T047;T037
36,288,571
enantioselect synthesi n benzyl heterocycl niphotoredox dual catalysi asymmetr cross coupl n heterocycl trifluorobor aryl bromid use niphotoredox dual catalysi develop c sp c sp cross coupl provid access pharmaceut relev chiral n benzyl heterocycl good excel enantioselect bioxazolin biox use chiral ligand high throughput experiment signific streamlin reaction develop identifi biox ligand investig allow rapid optim condit new trifluorobor salt
D009532;D001965
T123;T196;T197
36,288,560
nanoliposom sens local osmolar tear film corneal surfac purpos local hotspot elev tear hyperosmolar exceed mosm predict dri eye diseas ded measur studi aim develop character evalu suitabl fluoresc nanoliposom noninvas sens local osmolar tear film method fluoresc nanoliposom load calcein suscept self quench sensor dye sulforhodamin sr refer dye produc thin film hydrat method result dynam light scatter measur cryo tem show liposom negat charg mv spheric diamet nm uniform size polydispers index properti unaffect cold storag c day dye leakag signific day swell shrinkag liposom exposur hypoosmot hyperosmot media led rapid dequench quench calcein fluoresc f green effect sr fluoresc f red ratio f green f red decreas increas osmolar vice versa obey boyl va nt hoff relationship liposom dispers gelatin film dynam radial sucros gradient local f green f red decreas increas hyperosmolar predict instil hydrophil surfac contact lens ex vivo cornea nanoliposom dispers even thin film import measur f green f red declin continu evapor consequ increas osmolar conclus studi provid proof principl noninvas measur local tear film osmolar base osmosensit fluoresc nanoliposom strategi potenti advanc understand pathophysiolog ded
D008081;D015352
T184;T047;T109
36,288,559
ocular distribut pharmacokinet oxo deoxyguanosin novel therapeut candid ocular surfac diseas purpos studi evalu ocular distribut plasma pharmacokinet pks oxo deoxyguanosin oxo dg rabbit rat respect method test formul contain radiolabel c oxo dg unlabel oxo dg ocular administ rabbit singl dose mg per bodi intraven inject rat singl dose mgkg ocular distribut c oxo dg evalu use autoradiographi h postdos plasma radioact rabbit rat determin h respect result ocular instil c oxo dg distribut ocular tissu high radioact concentr observ ciliari bodi conjunctiva cornea maximum plasma concentr c max area concentr time curv auc highest ciliari bodi conjunctiva respect conjunctiva cornea aqueous humor time reach c max max h half live h respect radioact c oxo dg plasma rabbit display doubl peak phenomenon second peak consid c max ng eqml occur h postdos system exposur c oxo dg rat rapid declin initi phase termin half life h observ conclus rapid ocular distribut high concentr anterior ocular tissu minim system exposur observ ocular instil oxo dg rabbit pk profil favor treatment ocular surfac diseas
D003315;D005128
T023;T047
36,288,558
lidocain hydrochlorid gel ocular surfac anesthesia pharmacokinet evalu random placebo control trial china background new generic formul lidocain hydrochlorid ophthalm gel develop china studi aim evalu pharmacokinet effect lidocain hydrochlorid gel ocular surfac anesthesia method pharmacokinet studi new form lidocain hydrochlorid gel akten lidocain hydrochlorid gel appli eye rabbit ocular tissu plasma sampl collect applic lidocain hydrochlorid gel akten lidocain gel analyz use liquid chromatographi tandem mass spectrometri lc msms method determin concentr lidocain multicent random doubl blind prospect clinic trial conduct chines adult two hundr twenti particip random sham gel group lidocain hydrochlorid group primari efficaci endpoint defin percentag subject achiev anesthesia min result anim pharmacokinet studi show lidocain level signific higher choroid min vitreous bodi min lower tear h lidocain hydrochlorid gel akten p clinic trial show percentag subject achiev anesthesia within min lidocain hydrochlorid gel group signific higher sham gel group p incid advers event relat low favor group conclus new formul lidocain hydrochlorid gel pharmacokinet similar akten may exert sustain effect safe anesthet effect clinic trial new generic formul lidocain hydrochlorid regist drug clinic trial registr inform public platform establish state food drug administr china registr ctr
D000758;D008012
T061;T121;T109
36,288,554
zbtb regul prolactin express lactotrop function adult mice lactotrop prolactin prl secret endocrin cell anterior pituitari establish zinc finger protein zbtb essenti transcript factor lactotrop specif disrupt result complet loss lactotrop mice howev potenti role zbtb matur lactotrop remain unclear demonstr zbtb act critic cell autonom regul prl express matur lactotrop adult mice via crisprca approach first generat tamoxifen induc prl creer knockin mous line could effici mediat gene recombin specif lactotrop condit delet zbtb gene specif matur lactotrop adulthood led substanti decreas prl level pituitari plasma without signific alter lactotrop relat densiti pituitari male femal mice furthermor condit disrupt zbtb adult femal mice signific chang pregnanc elicit lactotrop expans caus impair mammari gland expans lactat due prl defect thus data point import role zbtb regul prl express lactotrop function adulthood
D011388;D010903
T125;T121;T023;T116
36,288,549
hydroxid chemoselect chang water microsolv solvent molecul known affect chemic reaction especi interact one reactant catalyst ion microsolv ie solvent molecul first solvat sphere strong electron interact creat lead signific chang charg distribut consequ nucleophilicityelectrophil aciditybas despit long histori research field fundament issu regard effect ion microsolv still open especi condens phase use reaction hydroxid relat stabl quaternari ammonium salt exampl show water microsolv chang hydroxid chemoselect differ affect basic nucleophil exampl hydroxid reactiv nucleophil less affect water microsolv reactiv base dispar discuss calcul compar oxid potenti polariz differ water hydroxid cluster
D014867;D006878
T121;T197
36,288,542
role social bias race condom use willing prescrib hiv pre exposur prophylaxi msm experiment vignett base studi daili antiretrovir pre exposur prophylaxi prep safe effect method prevent hiv clinician assumpt bias judgment may imped access prep specif concern patient engag condomless sex risk compens cite clinician reason prescrib prep
D065129;D015658;D000072339
T061;T047;T098
36,288,532
barrier provid lactat servic support famili appalachia mix method studi lactat profession support object understand barrier facilit lactat profession support lpss appalachian region unit state experi provid servic support famili method use mix method explanatori sequenti design survey lpss appalachia marchjuli follow semistructur interview lpss januaryapril summar survey respons descript analyz interview transcript themat result survey complet lpss appalachia conduct semistructur interview lpss survey particip common identifi challeng health care provid hospit practic nonmed indic supplement barrier interview particip describ challeng client famili support breastfeed difficulti reach client limit number lpss lack racialethn divers among lpss lpss identifi need train lactat substanc use mental health birth trauma support lesbian gay bisexu transgend queer question plus lgbtq famili lpss describ social media telehealth facilit barrier social support lpss facilit conclus lpss appalachia face various challeng address challeng potenti improv lactat support servic famili appalachia receiv j public health https doiorgajph
D001942;D000072339
T098;T055;T058;T040
36,288,529
iron defici unit state limit guidelin data monitor dispar iron defici sever sequela iron defici anemia public health problem associ morbid mortal particular among pregnant women younger children center diseas control prevent recommend prevent control iron defici unit state old reflect recent evid foundat refer mani feder clinic program guidelin surveil data iron defici spars level critic gap pregnant women younger children anemia iron defici iron defici anemia often conflat clinic guidelin anemia iron defici iron defici anemia give inconsist recommend caus nonsystemat assess iron defici screen iron defici typic reli identifi anemia despit anemia low sensit iron defici nation health nutrit examin survey iron defici miss among pregnant women children reli hemoglobin iron defici screen improv assess diagnosi strengthen surveil better complet data updat foundat guidanc iron defici anemia need consid new evid measur interpret laboratori result j public health https doiorgajph
D000090463;D018798;D000740
T047
36,288,521
breast milk feed infant birth among peopl confirm sar cov infect pregnanc set net state march decemb object describ preval breast milk feed among peopl sever acut respiratori syndrom coronavirus sar cov infect pregnanc examin associ breast milk feed time matern infect deliveri room status deliveri hospit method perform retrospect cohort studi use data massachusett minnesota nebraska pennsylvania tennesse whether peopl confirm sar cov infect pregnanc initi breast milk feed birth result among weight number peopl sar cov infect pregnanc confid interv ci initi breast milk feed birth hospit peopl infect within day deliveri signific lower preval breast milk feed adjust preval ratio apr ci infect least day deliveri stratifi room status associ time infect breast milk feed remain among infant room mother apr ci conclus pregnant postpartum peopl sar cov infect access lactat support advis import breast milk feed safe feed infant room j public health https doiorgajph
D000086382;D011251
T047;T067
36,288,519
effect sugari drink countermarket video caregiv attitud intent serv fruit drink toddler milk young children object test effect countermarket video address common mispercept ingredi claim children sugari drink method conduct onlin random control experi januari us caregiv n young children age month assess effect watch countermarket versus control video intent serv sugari healthi drink point scale attitud point scale fruit drink toddler milk result countermarket video signific reduc posit attitud fruit drink mean differ toddler milk mean differ reduc intent serv mean differ respect increas intent serv plain milk mean differ versus control video p intent differ individu characterist video remain effect control characterist moreov video effect toddler milk versus fruit drink effect fruit drink intent greater black versus white caregiv caregiv children age month younger conclus countermarket campaign aim divers caregiv young children design correct mislead children drink market present promis public health approach reduc sugari drink consumpt first day j public health https doiorgajph
D008892;D000080845
T168;T031
36,288,511
crisprca precis regul dna templat silver nanoclust fluoresc sensor meat adulter detect meat adulter caus consum fraud food allergi religi issu rapid sensit detect method urgent demand supervis meat authent herein cluster regular interspac short palindrom repeat crispr cas precis regul dna templat silver nanoclust dna agnc sensor ingeni design detect meat adulter specif sequenc recognit crisprcasa allow accur identif target dna emerg label free fluoresc probe dna agnc class promis fluorophor biochem analysi attract photost remark enhanc fluoresc properti first introduc substrat crisprcasa system allow sensit output amplifi signal precis regul uniqu target dna activ tran cleavag activ casa base specif recognit effici signal transduct crisprcasa outstand fluoresc properti dna agnc propos strategi achiev satisfactori linear rang pm limit detect lod low pm achiev sensit detect meat adulter
D012834;D015374
T196;T059;T075
36,288,509
construct scheme ag moo znfe nanofib heterojunct enhanc photoelectrocatalyt activ visibl light irradi remov organ dye pathogen bacteria contamin water remain signific challeng present studi type heterojunct ag moo znfe amozfo composit nanofib synthes electrospin co precipit fabric photoanod found construct type heterojunct amozfo composit effect inhibit recombin photogener carrier addit benefit expos activ site greater specif surfac area sever properti improv amozfo composit exhibit excel photoelectrocatalyt perform result demonstr visibl light irradi photoelectrocatalyt degrad rate amozfo methylen blue reach within min kill rate salmonella within min enhanc photoelectrocatalyt activ due synergi electrochem photocatalyt effect import four test cycl amozfo still better abil kill pathogen bacteria degrad organ dye due high stabil work provid feasibl method oxid organ dye pathogen bacteria
D057139
T073
36,288,502
droplet tweezer base hydrophil hydrophob interfac structur biolog applic droplet control oper wide applic microfluid biomedicin microreactor field droplet spontan transfer high energi state low energi state revers transfer droplet difficult task articl use special hydrophil hydrophob interphas structur hhis achiev revers transfer specif studi critic condit droplet transfer achiev length hydrophil surfac structur hydrophilichydrophob properti surfac must appropri rang base optim structur use transfer droplet design final carri research biolog applic success achiev transfer droplet zebrafish egg zebrafish larva uniqu method low cost biofriend high applic various surfac illustr great potenti chemic biolog analysi
D015027;D044085
T090;T013
36,288,497
nonunion coracoid base secondari cutibacterium acn infect surgic naiv patient case report present case year old man coracoid base fractur progress nonunion patient underw percutan autolog bone marrow deminer bone matrix dbm graft month injuri intraop cultur posit cutibacterium acn patient prior surgeri began shave axilla around time injuri treat amoxicillin week follow comput tomographi demonstr complet fractur heal
D005599;D050723;D001688
T121;T123;T046;T037
36,288,475
singl vesicl infrar nanoscopi noninvas tumor malign diagnosi protein heterogen molecular express structur determin tumorigenesi diagnost therapeut cancer biomark small extracellular vesicl sev cell releas nanosc membran bound vesicl transfer bioactiv molecul intercellular communic play essenti role tumor progress metastasi therefor protein heterogen tumor deriv sev indic degre malign transform provid noninvas biomark cancer diagnosi malign evalu employ near field infrar nano ftir spectroscopi investig malign relat protein heterogen singl sev demonstr discrimin sev protein heterogen evalu tumor malign metastasi found amid iii adsorpt ratio sev increas tumor malign proport helix random coil helix random coil sev protein decreas tumor malign proport sheet turn sheet turn increas tumor malign nano ftir spectral signatur sev primari tumor tissu breast cancer patient show high sensit specif evalu tumor metastasi studi show advantag nano ftir singl sev character demonstr signific sev protein heterogen cancer diagnosi provid noninvas solut elucid cancer develop facilit exploit potenti cancer biomark
D000067128;D009369
T026;T191
36,288,465
potent uncompetit inhibitor nicotinamid n methyltransferas nnmt vivo chemic probe nnmt use sam cofactor catalyz methyl nicotinamid produc methylnicotinamid recent studi shown nnmt upregul cancer associ fibroblast caf requir maintain caf phenotyp high grade serous carcinoma observ suggest nnmt evalu therapeut target especi cancer although sever small molecul inhibitor nnmt identifi remain need high potent select inhibitor excel vivo activ adm properti use reliabl chemic probe identifi azaindolin carboxamid select potent nnmt inhibitor favor pkpd safeti profil well excel oral bioavail pharmaceut properti mechanist studi indic bind uncompetit sam competit nicotinamid consist bind nicotinamid bind site like form posit interact sam
D050903;D009536
T121;T116;T127;T109;T126
36,288,453
screen halogen enrich fragment librari lead unconvent bind mode conceiv halogen enrich fragment librari heflib investig potenti halogen bond earli stage drug discoveri number competit interact increas ligand size reason bind mode reli halogen bond like fragment high decor molecul thus fragment could featur unexplor bind mode screen heflib human kinas dyrka verifi micromolar bind fragment via isotherm titrat calorimetri itc crystal structur one fragment reveal noncanon bind mode despit fragment classic hing bind motif addit fragment occupi secondari bind site bind mode featur halogen bond evalu ab initio calcul structur affin relationship sar set analogu improv affin provid promis fragment growth vector highlight benefit applic halogen bond earli lead develop
D006219;D055808
T062;T196
36,288,448
care bereav parent nicu father miss piec puzzl grief infant death common experi bereav parent often seen neonat intens care unit nicu nicu staff tend focus mother support father often treat equal mother studi aim investig circumst care parent face infant death nicus
D007363;D001601
T041;T073;T093
36,288,447
antenat milk express lactat support intervent parent infant sever birth defect case seri diet high parent milk parent milk lifesav intervent critic ill infant lactat parent whose infant born birth defect requir surgic repair surgic infant short birth often struggl initi maintain milk suppli meet infant nutrit need antenat milk express identifi safe feasibl potenti effect strategi promot parent direct chestbreastfeed milk express lactat confid help parent attain lactat goal two case present illustr potenti use antenat milk express lactat support intervent parent surgic infant
D007774;D008892
T168;T031;T042
36,288,446
preval incid persist postpartum anxieti depress comorbid cohort studi among women havana cuba estim preval incid persist postpartum anxieti depress comorbid symptom first month postpartum cohort havana women evalu sensit specif predict power edinburgh postnat depress scale epd state trait anxieti inventori stai week postpartum depress anxieti symptom week
D019052
T048
36,288,445
father experi alberta famili integr care qualit studi famili integr care ficar program adapt alberta ab level ii neonat intens care unit nicus aim increas parent involv support nicu stay experi father preterm infant ficar program current unknown
D007234;D019033
T033;T058;T100;T093
36,288,443
nurs driven intervent improv elbw neurodevelopment outcom surviv rate extrem low birth weight elbw infant improv neurodevelopment impair ndi rate stay stabl therebi increas overal number infant ndi although mani determin ndi popul nutrit factor interest readili modifi clinic set nurs influenc nutrit factor improv access human milk feed use growth monitor establish feed polici implement oral care colostrum facilit kangaroo care provid lactat educ mother measur assist lead decreas ndi rate among elbw infant
D052577;D009035
T092;T047;T099
36,288,441
explor perinat nurs care opioid use disord knowledg stigma compass opioid epidem great increas number pregnant women opioid use newborn expos opioid utero mother opioid use disord face stigma nurs perinat care set contribut negat care experi survey distribut nurs care mother newborn expos opioid larg urban hospit pacif northwest unit state n march juli survey measur includ particip characterist attitud toward substanc use pregnanc postpartum stigma compass satisfact comfort knowledg open end question relationship among variabl questionnair item examin use pearson correl sampl test simultan multipl linear regress qualit descript use analyz open end question nurs stigma negat correl compass satisfact r feel knowledg r comfort provid care popul r nurs identifi defens lack trust inadequ social support key challeng patient popul nurs suggest support mother nurs increas nurs educ clinic guidelin improv clinic practic foster therapeut relationship find highlight potenti strategi improv nurs care chemic depend mother infant strategi may offer practic approach reduc stigma develop therapeut relationship improv patient outcom
D017283;D009732;D009293
T058;T091;T048
36,288,440
exploratori analysi matern health variabl increas sever congenit heart diseas infant congenit heart defect chd preval birth anomali lead caus infant morbid mortal worldwid heart defect often attribut chromosom abnorm environment factor caus remain unknown purpos analysi explor matern health variabl relationship birth outcom infant chd
D006330;D006973
T019;T047
36,288,405
share biophys mechan determin earli biofilm architectur develop across differ bacteri speci bacteri biofilm among abund multicellular structur earth play essenti role wide rang ecolog medic industri process howev general principl govern emerg biofilm architectur across differ speci remain unknown combin experi simul statist analysi identifi share biophys mechan determin earli biofilm architectur develop singl cell level speci vibrio cholera escherichia coli salmonella enterica pseudomona aeruginosa grown microcoloni flow chamber data driven analysi reveal despit mani molecular differ speci biofilm architectur differ describ control paramet cellular aspect ratio cell densiti experi use singl speci mutant cell aspect ratio cell densiti systemat vari mechanist simul show tune control paramet reproduc biofilm architectur differ speci altogeth result show biofilm microcoloni architectur determin mechan cell cell interact conserv across differ speci
D018441;D014734
T007
36,288,404
analysi interfac mechan properti geotextil tail pull test consid strain soften characterist pull interfac geotextil tail determin interfac interact characterist paper propos trilinear shear stress displac soften model geotextil reinforc tail obtain nonlinear govern equat dimensionless express finit differ form result indic accur numer solut could obtain within reason calcul time discret reinforc length unit three new dimensionless interact term name relat stiff relat displac relat interfac shear stiff reinforc tail interact introduc addit estim method base approxim valu relat stiff reinforc soil interfac low tensil forc displac rang propos interfac shear stress rang accord paramet parameter normal relationship tensil forc pull end displac determin numer valu calcul model compar pull test result demonstr propos model accur predict pull behavior extens reinforc
D055595;D012987
T070;T167
36,288,402
sequenc protein influenc mrna process trypanosoma brucei evolutionari conserv sr domain ptb protein function splice leader tran splice addit short cap sequenc end mrnas widespread eukaryot evolut factor influenc tran splice acceptor site choic littl investig kinetoplastid protein code mrnas tran splice polypyrimidin tract usual found upstream ag splice acceptor branch point consensus moreov splice dictat polyadenyl preced mrna valid drug target
D014346
T204
36,288,398
temperatur settlement characterist grade crush rock layer runway engin permafrost region maintain temperatur settlement stabil subgrad combin grade crush rock layer insul layer may appli optim pavement structur studi verifi propos numer model pavement subgrad design permafrost region evalu temperatur settlement characterist differ particl size thick grade crush rock layer differ thick locat insul layer result show temperatur settlement combin grade crush rock layer insul layer decreas signific particl diamet thick grade crush rock layer increas vari littl thick insul layer locat instal layer signific influenc temperatur subbas layer littl influenc temperatur subgrad maximum settlement pavement structur subgrad decreas instal layer vari top subbas layer bottom subbas layer optim combin grade crush rock layer insul layer thick instal layer bottom thick grade crush rock layer particl size cm studi provid theoret basi design construct oper mainten safeti manag airport runway permafrost region
D065946
T083;T167
36,288,397
secret life babi turtl novel system predict hatchl emerg detect infertil nest remot monitor sea turtl nest event current understand sea turtl nest hatch emerg event larg limit observ event surfac sand though recent approach use audio visual equip allow scientist better understand underground nest phenomena use technolog base approach defin motion relat caretta caretta hatch emerg nest event describ novel low cost acceleromet base system call turtlesens detect movement temperatur within sea turtl nest remot turtlesens success abl specif detect motion within sea turtl nest entir cours incub system allow identif infertil nest detect four predict sequenti development activ pattern viabl nest includ hatch posthatch period time use tight predict hatchl emerg event almost day turtlesens provid much better understand happen nest emerg allow generat theori mechan trigger mass emerg result suggest motion play larg role hatchl communic time emerg event may relat cessat movement within nest current manag sea turtl nest event primarili driven count number day sinc nest laid safeguard place nest upon subsequ visual observ depress emerg event use turtlesens technolog impact nest manag conserv effort allow organ use motion data tight predict emerg date sea turtl hatchl use viabil data inform nest manag decis
D014426
T014
36,288,396
uptak key essenti nutrit action ena messag predictor among mother children age month southern ethiopia communiti base crossect studi essenti nutrit action ena framework manag advocaci establish foundat implement comprehens packag prevent nutrit activ essenti nutrit action studi studi provid current inform nutrit action allow health system focus nutrit critic tackl doubl burden malnutrit underweight overweight henc studi aim assess level ena practic predictor among mother children age month southern ethiopia
D007455;D009035
T123;T121;T092;T196;T099
36,288,395
leptospira enrich cultur follow ont metagenom sequenc allow better detect leptospira presenc divers water soil sampl leptospirosi life threaten diseas human anim one widespread global zoonosi contamin soil water major transmiss sourc human anim cluster diseas outbreak common raini season
D007919;D007922
T047;T007
36,288,392
understand high risk acut myeloid leukemia analyz interactom major driver mutat classifi posit acut myeloid leukemia aml subgroup high risk aml clinic biolog peculiar young age therapi resist encod deknup fusion oncoprotein target small subpopul bone marrow progenitor leukem transform distinguish deknup fusion oncoprotein pmlrar runxeto mllaf broad target popul block differenti increas stem cell capac common theme among leukemogen fusion protein aberr local compar wild type counterpart although actual consequ wide unknown seem contribut leukemogenesi like sequest interact partner thus appli global approach studi consequ aberr local deknup interactom studi aim disclos role local deknup relat sequest protein interact deknup determin biolog aml show complex biolog consequ express deknup depth bioinformat analysi interactom deknup biolog dead mutant deknup interactom point essenti role aberr rna regul aberr regul apoptosi leukocyt activ signific determin phenotyp aml taken togeth provid evid interactom contribut aberr biolog oncoprotein provid opportun develop novel target therapi approach
D015514;D015470
T191;T116
36,288,391
negat air ion action antioxid anti inflamm anti apoptosi angiogenesi amelior lipopolysaccharid induc acut lung injuri promot diabet wound heal rat negat air ion nai bioactiv negat charg molecul may confer antioxid anti inflammatori activ assess effect nai two inflammatori diseas anim model includ lipopolysaccharid lps induc acut lung injuri ali wound heal diabet rat use intra tracheal infus lps induc ali made full thick cutan wound streptozotocin induc diabet femal wistar rat evalu nai effect reactiv oxygen speci amount leukocyt infiltr wound heal rate western blot immunohistochemistri lung ali skin section wound data found nai expos salin display higher antioxid activ vs non expos salin nai exposur signific affect arteri blood pressur respiratori frequenc control lps treat group lps increas leukocyt infiltr caspas poli adp ribos polymeras mediat apoptosi format decreas beclin lc ii mediat autophagi lung nai exposur confer pulmonari protect depress leukocyt infiltr caspas poli adp ribos polymeras mediat apoptosi enhanc lc ii mediat autophagi lps induc ali nai treatment result signific acceler wound closur rate decreas erythrocyt accumul leukocyt infiltr mediat oxid stress inflamm upregul express skin collagen vascular endotheli growth factor receptor vegfr factor transform growth factor beta tgf vs non treat group base result suggest nai confer protect upregul lc ii depend autophagi mechan downregul leukocyt infiltr mediat inflamm caspas poli adp ribos polymeras signal lps treat ali promot diabet wound heal enhanc skin collagen synthesi vegfr tgf pathway
D003921;D055371
T050;T037
36,288,390
estim treatment cost uncompl diabet hospit serv refuge kenya diabet mellitus dm increas mark low middl incom countri three quarter global death occur due non communic diseas unfortun condit consid cost often depriorit humanitarian set compet goal use mix method approach studi aim quantifi cost outpati treatment uncompl type tdm type tdm diabet secondari care facil serv refuge kenya retrospect cost analysi combin micro gross cost provid perspect employ main outcom includ unit cost per health servic activ cover total cost labor capit medic consum overhead care pathway map uncompl diabet patient identifi direct indirect medic cost interview conduct determin input requir diabet care estim staff time alloc total patient predomin somali refuge treat tdm n tdm n outpati consult identifi n male n femal total test run set random blood sugar rbs test hbac test mean cost estim per outpati consult per rbs test per hbac test annual pharmacotherapi regimen cost tdm tdm invest holist sustain non communic diseas manag forefront humanitarian respons expect benefici immedi implic covid respons also reduc burden care time despit studi limit essenti servic manag uncompl diabet humanitarian set modest afford therefor integr diabet care primari health care fundament pillar long term polici respons stakehold
D003922;D003924;D012036;D000086382
T047;T098;T067
36,288,388
associ health relat qualiti life measur adipos among filipino adult estim associ health relat qualiti life hrqol adipos low incom popul
D050154;D011788
T078;T032
36,288,387
feedback loop mettl usp regul cell migrat invas emt well metastasi bladder cancer bladder cancer bca one preval malign global previous studi report inhibitori effect methyltransferas like mettl bca tumorigenesi role cell migrat invas epitheli mesenchym transit emt bca remain unknown
D001749;D035683
T123;T191;T114
36,288,385
effici malaysian state manag covid outbreak mani develop countri drastic imbalanc health system differ region covid outbreak pose challeng hospit structur equip doctor critic care unit respir avail suffici extent region
D000086382
T047;T067
36,288,384
work time alloc primari health care level two region albania although well perform workforc essenti equit effici health servic deliveri countri systemat address perform improv health worker use work time task accomplish import start point therefor time motion studi conduct assess work time alloc pattern primari health care doctor nurs two region albania
D058873;D000086382
T047;T067
36,288,383
elast potenti yield surfac isotrop materi paper propos elast potenti may rigor formul use negat gibb free energi complementari strain energi densiti may use yield surfac elasto plastic constitut model thus yield surfac may assum materi elast potenti surfac specif level critic complementari strain energi densiti tradit approach total strain energi criterion consid second order term ie elast potenti centr origin current stress state first order term consid consequ elast potenti may translat allow reproduc desir level tension compress asymmetri propos approach add two addit paramet eg uniaxi compress tensil yield limit elast one linear elast propos approach provid ellipt yield surfac show correl shape ellips poisson ratio agre publish experiment data soil metal glass ellipt yield surfac also fit well experiment valu amorph polym rock besid propos approach automat consid influenc intermedi stress non linear elast wider rang elast potenti ie yield surfac possibl distort ellipsoid case incompress non linear materi yield surfac von mise tresca one
D010969;D012987
T167