PMID
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36.4M
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36,286,528
|
imag inflammasom activ microglia inflammasom multiprotein complex play key role host innat immun respons insult assembl inflammatori complex initi oligomer upstream inflammasom form sensor follow well orchestr multi step process lead downstream effector function critic innat immun respons final assembl step provid detect readout inflammasom complex activ form apoptosi associ speck like protein contain card asc speck inflammasom activ releas il asc speck microglia brain resid immun cell implic various neurolog neurodegen disord protocol exist generat fluoresc inflammasom indic peripher macrophag build upon protocol describ protocol detail generat fluoresc inflammasom indic microglia cell use recombin retrovirus transduc murin bv cell protocol cell establish manner allow experiment control initi prime step inflammasom activ process provid seri step use report cell within inflammasom activ assay use real time imag asc speck format indic inflammasom activ addit describ strategi use cell examin effect test substanc inflammasom activ protocol offer effect approach conduc screen examin modif microglia inflammasom activ due exposur chemic pharmacolog agent publish articl us govern work public domain usa basic protocol product retrovirus express inflammasom indic basic protocol generat inflammasom indic bv cell basic protocol prime activ bv asc cerulean cell inflammasom activ assay basic protocol examin modif inflammasom activ test substanc basic protocol imag analysi asc speck format
|
D058847;D053468
|
T123;T116
|
36,286,506
|
experi middl age older taiwanes adult chronic insomnia descript qualit studi purpos current studi describ experi middl age older adult chronic insomnia descript qualit studi design use semi structur interview conduct particip two primari clinic health center northern taiwan mean age particip year particip middl age age year mean durat insomnia year three theme emerg imperfect live experi dilemma whether take hypnot seek help altern therapi particip believ chronic insomnia contribut accumul anxieti negat emot result psycholog burden particip insomnia negat impress hypnot usual sought altern therapi improv sleep health care provid endeavor understand need individu insomnia provid sleep hygien knowledg assist safe sleep practic journal gerontolog nurs
|
D007319
|
T184;T047;T048
|
36,286,505
|
standard posit physic approach improv oral hygien nurs home resid alzheim diseas relat dementia resid alzheim diseas relat dementia adrd nurs home nhs reli direct care worker dcws assist activ daili live oral hygien current qualiti improv project implement evalu effect teach standard posit physic approach oral hygien complet patient adrd resid nh pre postintervent evalu incorpor video present coupl hand simul experi show statist signific improv dcws overal sens compet dementia score well subcategori sens compet dementia care staff survey addit resid day shift oral hygien care complet rate increas month pre postintervent nhs consid implement train includ hand experi equip dcws knowledg skill need improv oral hygien among resid adrd journal gerontolog nurs
|
D000544;D005851
|
T047;T091;T048
|
36,286,504
|
educ polici advocaci predict use hospit order skill nurs facil nurs social worker uniqu posit advoc patient wish hospit dnh direct purpos current studi explor impact dnh educ polici advocaci use dnh order nurs rns licens practic nurs lpns social worker employ skill nurs facil snfs multisit secondari analysi use cross section survey data analyz respons rns lpns social worker n urban snfs mix model regress use examin possibl predictor frequenc dnh order within snfs adjust random effect result show dnh written polici educ dnh order advanc care plan advoc facil strong associ higher report frequenc dnh discuss resid famili p variabl journal gerontolog nurs
|
D012866;D057766
|
T170;T073;T093
|
36,286,503
|
feasibl physic train intervent music communiti dwell older women quasi experiment studi physic activ perform music activ import brain area associ cognit emot motor skill limit inform avail feasibl accept physic activ music intervent current studi aim determin feasibl physic train intervent music older women b describ differ pretest posttest variabl ie cognit state immedi memori execut function gait paramet cadenc gait speed muscl strength flexibl symptom depress result suggest intervent physic train music feasibl given high accept retent rate high level attend session absenc advers event signific improv observ immedi memori p execut function p cadenc p leg strength p right arm strength p left arm strength p symptom depress p left lower bodi flexibl p therefor random clinic trial larger sampl could confirm effect intervent memori execut function cadenc leg strength arm strength symptom depress left lower bodi flexibl journal gerontolog nurs
|
D057187;D009146
|
T056;T170
|
36,286,502
|
continu commit long term care rns experi communic resid famili end life care prefer rns lead care plan long term care ltc yet knowledg gap regard communic resid famili end life eol care prefer sampl ltc rns virtual interview describ eol care communic experi use interpret phenomenolog framework narrat analysi within interpret constructiv paradigm yield four concept togeth becom clear becom comfort advocaci honor resid uniqu impact nurs part rns commit continu dynam eol care communic process nurs commit ongo whole person assess educ becom proactiv advoc resid center goal concord care knowledg experienti deriv nurs educ adequ prepar eol care communic complex multidimension relationship resid famili research need evalu natur interact relat contribut compon eol care communic ltc journal gerontolog nurs
|
D013727;D017051;D005851
|
T058;T091;T093
|
36,286,501
|
older adult famili caregiv perspect engag primari care purpos current depth qualit studi explor experi older adult famili caregiv primari care twenti patient caregiv six comprehens primari care plus cpc practic patient famili advisori council within larg academ health system particip telephon interview decemb may particip most women averag age year nine chronic condit transcript code use convent content analysi two key theme emerg relat person center care pcc engag health care patient provid relationship engag health care defin particip proactiv center patient goal treatment discuss adher self triag approxim particip discuss import relationship interact provid influenc engag identifi theme offer recommend improv primari pcc journal gerontolog nurs
|
D017028;D012648
|
T099;T098;T097;T056
|
36,286,484
|
nonlyt quasi envelop hepatovirus releas facilit px protein interact e ubiquitin ligas itch hepatovirus atyp hepatotrop picornavirus releas infect cell without lysi small membran vesicl exosom like quasi envelop virion ehav infecti form hepat virus hav found circul blood acut infect ehav releas multivesicular endosom process depend endosom sort complex requir transport escrt capsid protein interact escrt associ bro domain protein alg interact protein x alix domain contain protein tyrosin phosphatas hd ptp recruit px domain vppx critic process previous proteom studi suggest px also bind hect domain nedd famili e ubiquitin ligas itch confirm interact show itch bind direct carboxi termin half px human bat hepatovirus independ alix small chemic compound compound design disrupt interact ww domain nedd ligas substrat molecul block itch bind px demonstr substanti antivir activ hav crispr delet small interf rna sirna knockdown itch express inhibit releas self assembl nanocag protein fuse px also impair releas ehav infect cell releas could rescu overexpress wild type itch catalyt inact itch mutant despit found evid itch ubiquityl px ehav releas strong depend upon lys residu px data indic itch play import role escrt depend releas quasi envelop hepatovirus although substrat molecul target ubiquityl remain determin import mechan under cellular releas quasi envelop hepatovirus partial understood yet play crucial role pathogenesi common agent viral hepat multipl nedd famili e ubiquitin ligas includ itch report promot bud convent envelop virus known function releas hav picornavirus infect cell show uniqu c termin px extens vp capsid protein hav interact direct itch itch promot ehav releas manner analog role bud convent envelop virus catalyt activ itch requir effici ehav releas may potenti function ubiquityl viral capsid activ escrt compon
|
D044767;D030041
|
T005;T126;T116
|
36,286,483
|
epstein barr virus viral process factor ea facilit virus lytic replic induc poli adp ribos polymeras degrad gammaherpesvirus includ epstein barr virus ebv import human pathogen associ various tumor poli adp ribos polymeras parp multifunct host nuclear protein respons poli adp ribosyl ation paryl target protein parp act negat regul suppress lytic replic gammaherpesvirus virus often equip various strategi overcom parp inhibit howev mechan ebv may modul repress host protein parp still elus studi found ebv reactiv induc parp downregul ebv infect cell ebv dna polymeras process factor ea encod bmrf gene direct interact central automodif domain ad parp necessari suffici downregul parp via k link polyubiquitin moreov knockdown ea b cell restor parp level abrog express zta also known zebra switch molecul ebv life cycl reactiv interest parp paryl rta anoth key switch molecul decreas rta transactiv promot zta bmrf bmlf gene ea allevi paryl rta enhanc rta mediat transactiv lytic promot report assay taken togeth result suggest ebv viral process factor play key role facilit lytic replic induc parp degrad via interact parp ad high conserv mechan among gammaherpesvirus counteract host repress activ parp viral lytic replic import parp act negat regul lytic replic ebv success enter reactiv cycl ebv develop multipl strategi counteract host repress mechan studi investig ebv manipul host repress factor parp facilit lytic replic ebv process factor ea downregul parp proteasom depend manner via direct bind parp ad knockdown ea restor parp level inhibit zta express reactiv interest parp paryl rta ea reduc paryl rta therebi promot zta promot activ result suggest ea play key role ebv lytic replic induc parp degrad addit support dna replic viral process factor given kshv process factor also induc parp degrad enhanc rta function gammaherpesvirus share conserv molecular mechan overcom inhibitori effect parp promot lytic replic
|
D004854;D020031
|
T005;T047
|
36,286,482
|
cellular heterogen molecular reprogram host respons influenza acut lung injuri exuber host respons contribut influenza virus iav influenza mediat lung injuri howev despit signific inform host respons iav cellular framework molecular interact dictat develop acut injuri iav infect lung remain incomplet understood perform unbias singl cell rna sequenc scrnaseq analysi examin cellular heterogen regul host respons iav model acut lung injuri cellular level iav infect promot overwhelm recruit monocyt exhibit cell differenti trajectori monocyt deriv macrophag togeth monocyt monocyt deriv myeloid cell constitut total immun cell iav infect lung contrast iav infect result signific loss nonhematopoiet cell molecular data show multidimension cell cell communic dynam interferon chemokin signal immun nonimmun cell cell specif molecular pathway regul host respons iav induc lung injuri data provid foundat explor mechanist associ iav host respons acut lung injuri import dysregul host respons develop acut lung injuri iav infect howev patholog immun mechan associ acut lung injuri iav infect yet elucid studi perform scrnaseq examin dynam host respons peak iav mediat lung injuri cellular level data reveal signific myelopoiesi predomin monocyt macrophag simultan disrupt nonhematopoiet cell framework crucial regul inflamm barrier integr iav infect lung molecular observ complex cellular network involv cell cell communic number uniqu regulon dictat outcom interferon chemokin respons peak lung injuri data present uniqu atlas cellular chang regul global cell specif host respons iav infect expect inform open new avenu identifi target therapeut intervent iav lung injuri
|
D007251;D009976;D009980;D055371
|
T047;T005;T037
|
36,286,481
|
block autophagi macrophag enhanc virus replic eye diseas ocular infect transgen mice macrophag one first innat immun infiltr cornea mice follow ocular infect herp simplex virus hsv use gamma interferon ifn interleukin il inject polar macrophag respect condit knockout mice shown macrophag play import role suppress virus replic eye eye diseas hsv infect mice autophagi also import control hsv infect integr infect cell determin block autophagi macrophag affect hsv infect eye diseas generat two transgen mous strain express hsv autophagi gene promot promot found block autophagi macrophag increas virus replic eye eye diseas comparison block autophagi macrophag wild type wt control mice block autophagi affect latenc reactiv howev block autophagi affect fertil transgen mice analysi autophagi gene cytokineschemokin infect bone marrow deriv macrophag wt mice suggest upregul autophagi block gene ie hifa mtmr mtor mtmr stk ulk inflammatori tumor necrosi factor alpha tnf gene transgen mice correl increas pathogen upregul proautophagi gene nrbf rbcc macrophag correl reduc pathogen vivo vitro respons transgen mice hsv infect independ presenc gene wild type hsv result suggest macrophag macrophag play import role autophagi relat primari virus replic eye eye diseas infect mice import autophagi play critic role clear disassembl recycl damag cell thus limit inflamm hsv gene involv neurovirul immun evas block autophagi infect cell found block autophagi macrophag enhanc hsv virus replic eye eye diseas ocular infect transgen mice result also show suppress effect immun respons infect suggest import intact autophagi macrophag control primari infect eye diseas
|
D018259;D006561;D005128
|
T005;T047
|
36,286,478
|
integr exogen tune thraustochytrid ferment sulfur polymer singl cell oil develop plant like oil studi demonstr bioprocess approach encompass exogen addit low molecular weight compound tune fatti acid fa profil novel thraustochytrid strain produc desir fas maximum lipid recoveri dri wt biomass obtain tween mgl vitamin b transesterifi lipid show palmit acid c tfa stearic acid c tfa oleic acid c tfa main compon total fas main present plant oil strike limonen addit ferment medium repress product polyunsatur fatti acid pufa sulfur polymer guid lipid separ reveal presenc satur sfas tfa monounsatur fatti acid mufa tfa thraustochytrid oil mimic plant oil like fa profil work industri valuabl advoc use sulfur polymer prepar plant like oil tuneabl thraustochytrid lipid
|
D011136;D005227
|
T121;T123;T109;T168;T122
|
36,286,477
|
marin biolog macromolecul chemic modifi macromolecul potenti anticoagul coagul potenti defens mechan involv activ seri zymogen convert solubl fibrinogen insolubl fibrin clot prevent bleed hemorrhag complic prevent extra format diffus clot counterbal inhibitori mechan activ level coagul pathway contrariwis system evad normal control due either inherit acquir defect age lead unusu clot format abnorm format deposit excess fibrin trigger serious arteri cardiovascular diseas although heparin heparin base anticoagul wide prescrib class anticoagul clinic use heparin limit due unpredict anticoagul risk bleed complic henc signific interest establish year investig altern therapeut anticoagul natur sourc especi marin sourc good safeti potenc due uniqu chemic structur biolog activ review summar coagul cascad potenti macromolecular anticoagul deriv marin flora fauna
|
D000925;D013927
|
T121;T046
|
36,286,476
|
branch chondroitin sulfat oligosaccharid deriv sea cucumb acaudina molpadioid stimul neurit outgrowth fucosyl chondroitin sulfat fcs sea cucumb acaudina molpadioid fcs first one report branch disaccharid galnac fuc ss sulfat fuc four size homogen fraction seven oligosaccharid separ elimin depolymer product detail nmr spectroscop ms analys reveal oligom hexa hepta octa nonasaccharid confirm precis structur nativ fcs compos cs e like backbon full content sulfat galnac disaccharid repeat unit branch consist sulfat fucos fuc fuc ss heterodisaccharid galnac fuc ss pharmacolog fcs depolymer deriv includ fraction oligosaccharid show potent neurit outgrowth promot activ chain length depend manner comparison analys among oligosaccharid reveal sulfat pattern fuc branch instead heterodisaccharid could affect promot intens fuc ss saccharid length endow neurit outgrowth stimul activ
|
D012616
|
T204
|
36,286,475
|
bromoditerpen red seawe sphaerococcus coronopifolius potenti cytotox agent proteasom inhibitor relat mechan action seawe great sourc compound cytotox properti potenti use anticanc agent studi evalu cytotox proteasom inhibitori activ r hydroxi bromosphaerol hydroxi bromosphaerol bromosphaerol isol sphaerococcus coronopifolius cytotox evalu malign cell line caco hct mcf nci h pc sh syy sk mel use mtt ldh assay abil compound stimul product hydrogen peroxid h induc mitochondri dysfunct extern phosphatidylserin caspas activ chang nuclear morpholog also studi mcf cell abil induc dna damag also studi l fibroblast proteasom inhibitori activ estim molecular dock studi compound exhibit ic valu r hydroxi bromosphaerol hydroxi bromosphaerol increas h level mcf cell bromosphaerol induc dna damag fibroblast compound promot depolar mitochondri membran potenti caspas activ nuclear condens fragment compound shown interact chymotrypsin like catalyt site molecular dock studi howev hydroxi bromosphaerol evidenc interact ala ser key residu proteasom catalyt mechan studi outlin deepli character understand potenti bromoditerpen anticanc therapeut
|
D012624;D009447;D000461;D000970
|
T121;T109;T191;T204;T002
|
36,286,474
|
antimicrobi peptid lj hep lateolabrax japonicus exert activ multipl pathogen bacteria immun protect vivo hepcidin wide present mani kind fish import innat immun factor varieti hamp type hepcidin strong antimicrobi activ immunomodulatori function expect develop substitut antibiot studi antimicrobi activ hepc japanes seabass lateolabrax japonicus design lj hep investig use recombin precursor protein rlj hep express pichia pastori chemic synthes matur peptid lj hep result show rlj hep synthet lj hep display broad antimicrobi spectrum potent activ gram negat gram posit bacteria fungi especi lj hep stronger antimicrobi activ exhibit potent activ sever clinic isol multidrug resist bacteria includ acinetobact baumannii escherichia coli pseudomona aeruginosa klebsiella pneumonia enterococcus faecium moreov lj hep exert rapid bactericid kinet kill test bacteria within h induc signific morpholog chang promot agglutin e coli p aeruginosa aeromona hydrophila activ lj hep e coli p aeruginosa hydrophila stabl remain activ heat min addit lj hep exhibit cytotox mammalian cell line hekt fish cell line epc zf vivo studi show lj hep could improv surviv rate marin medaka oryzia melastigma challeng hydrophila indic immunoprotect function taken togeth rlj hep lj hep good prospect use potenti antimicrobi agent aquacultur medicin futur
|
D064451;D009990
|
T125;T123;T116;T013
|
36,286,473
|
structur investig aaptourinamin novel modul assembl base calcul natur product various complic structur still challeng elucid compound especi lack two dimension nuclear magnet reson nmr correl main caus high ch ratio proton defici multipl heteroatom convent structur analyt method report novel modul assembl calcul method name dooerafa includ construct meta structur graft method base crucial limit nmr correl ring contract strategi base mechan forc field quantum chemic theori self assembl calcul python program shape structur candid along dft giao calcul new method verifi known alkaloid spiroreticulatin structur determin x ray diffract perform structur elucid aaptourinamin isol marin spong aapto suberitoid show us brand new scaffold imidazo ij pyrrolo f quinolin h one biosynthet relationship bioactiv structur uniqu aaptamin alkaloid
|
D011161;D000470;D001688
|
T123;T121;T109;T131;T204
|
36,286,472
|
two laminaria japonica ferment broth allevi oxid stress inflammatori respons caus uvb damag photoprotect repar effect uvb radiat induc oxid stress inflammatori respons human epiderm cell establish uvb induc damag model human immort epiderm keratinocyt hacat explor protect repar effect laminaria japonica uvb damag epiderm inflamm ferment white ganoderma lucidum curti p karst saccharomyc cerevisia compar unfer laminaria japonica ferment laminaria japonica possess stronger vitro free radic scaveng abil laminaria japonica white ganoderma lucidum ferment broth lj g laminaria japonica rice wine yeast ferment broth lj effect remov excess reactiv oxygen speci ros cell increas content intracellular antioxid enzym heme oxygenas ho nad p h quinon oxidoreductas nqo addit ferment laminaria japonica effect reduc content pro inflammatori factor il tnf mmp secret cell molecular research result show ferment laminaria japonica activ nrf signal pathway increas synthesi antioxid enzym inhibit gene express level pro inflammatori factor allevi cellular oxid stress inflammatori respons caus uvb radiat base result conclud ferment laminaria japonica stronger antioxid anti inflammatori activ unfer laminaria japonica possess good safeti develop use function inflamm reliev ferment laminaria japonica polysaccharid slender morpholog structur rockulos better moistur rheolog properti
|
D007795;D014920
|
T121;T168;T204
|
36,286,471
|
meridianin inhibit gsk vivo improv behavior alter induc chronic stress major depress disord mdd sever mental alter multifactori origin chronic stress one relev environment risk factor associ mdd although exist therapeut option patient still resist type treatment gsk inhibitor consid promis therapeut tool counteract stress relat affect howev often associ excess target effect undesir secondari alter meridianin alkaloid indol framework link aminopyrimidin ring antarct marin ascidian meridianin could overcom sever aforement limit sinc previous demonstr inhibit gsk activ without associ neurotox target effect rodent show meridianin deliv later ventricl inhibit gsk sever brain region involv stress relat symptom also observ chang major signal pathway prefront cortex akt pka hippocampus pkc glur moreov meridianin increas synapt activ specif ca ca hippocamp subfield final chronic treat mice subject unpredict mild chronic stress cum paradigm meridianin result show improv produc meridianin behavior alter provok cum conclus meridianin could therapeut interest patient stress relat disord mdd
|
D006624;D051057
|
T026;T023;T126;T116
|
36,286,470
|
manzamin alter vitro calvari osteoblast function manzamin marin deriv alkaloid anti viral anti prolif properti current investig efficaci treatment certain virus malaria herp hiv cancer breast cervic colorect manzamin found exert effect via modul six gene express gene critic craniofaci develop via wnt notch pikakt pathway date littl work focus manzamin use may affect bone hypothes manzamin six alter bone cell activ assess effect manzamin cell respons generat bone pre osteoblast osteoblast pcr qrtpcr mts cell viabil caspas function assay use test effect manzamin cell data suggest six high express osteoblast progenitor osteoblast progenitor osteoblast exhibit great sensit manzamin treatment exhibit signific decreas cell viabil increas cellular apoptosi decreas alkalin phosphatas activ silico bind experi show manzamin potenti inhibitor cell prolifer surviv protein ie ib jak akt pkc fak bcl overal data suggest manzamin may great effect bone health overal may disrupt skelet develop homeostasi repair
|
D019869;D051057
|
T126;T116
|
36,286,469
|
prepar anticoagul antioxid properti glucosamin heparin salt excess inorgan ion vivo may lead electrolyt disord induc damag human bodi therefor prepar enhanc bioactiv compound compos activ organ cation organ anion great interest among research work glucosamin heparin salt ghs primarili synthes posit charg glucosamin hydrochlorid gah negat charg heparin sodium hep ion exchang method detail structur inform ghs character ftir h nmr spectroscopi icp ms addit anticoagul potenc antioxid properti evalu respect result demonstr ghs salt achiev enhanc antioxid activ includ radic scaveng activ oh radic scaveng rate dpph radic scaveng capac mgml sever meanwhil anticoagul potenc attp ghs strengthen moll thus introduc cation glucosamin residu ghs could improv anticoagul activ find suggest ghs product small amount inorgan ion great abat prime cost antioxid anticoagul signific econom benefit practic signific
|
D006493;D000925
|
T123;T121;T109
|
36,286,468
|
astaxanthin protect neuron excitotox via glutam receptor inhibit improv mitochondri function excitotox known associ neurodegen diseas alzheim diseas parkinson diseas amyotroph later sclerosi huntington diseas well age stroke trauma ischemia epilepsi excess releas glutam overactiv glutam receptor calcium overload mitochondri dysfunct excess reactiv oxygen speci ros format suggest key mechan astaxanthin ast carotenoid known act antioxid protect neuron excitotox injuri howev exact molecular mechan ast neuroprotect clear thus studi investig role ast neuroprotect excitotox util primari cortic neuron cultur live cell fluoresc imag studi result suggest ast prevent neuron death reduc ros format decreas abnorm mitochondri membran depolar induc excitotox glutam insult addit ast modul intracellular calcium level inhibit peak irrevers secondari sustain calcium level neuron furthermor ast regul ionotrop glutam subtyp receptor nmda ampa ka mitochondri calcium moreov ast decreas nmda ampa receptor protein express level ka remain unaffect overal result indic ast protect neuron excitotox neuron injuri regul ionotrop glutam receptor cytosol secondari calcium rise mitochondri calcium buffer henc ast could promis therapeut agent excitotox insult neurodegen diseas
|
D018698;D019636
|
T123;T047;T121;T116
|
36,286,467
|
exogen arachidon acid affect fucoxanthin biosynthesi photoprotect phaeodactylum tricornutum fucoxanthin oxygen carotenoid compon report play import role anti oxid anti obes anti cancer human bodi fucoxanthin chlorophyl protein fcp complex particip light harvest photoprotect diatom order better understand chang fucoxanthin content role photoprotect growth fucoxanthin biosynthesi photosynthet phenotyp studi diatom phaeodactylum tricornutum treatment exogen arachidon acid aa result demonstr even low concentr aa mgl strong induc fucoxanthin accumul algal cell maximum mgg dri weight dw higher untreat one princip compon analysi pca also identifi close correl fucoxanthin accumul express gene involv fucoxanthin biosynthesi especi phytoen synthas psi suggest aa chang metabol fucoxanthin induc carotenoid metabol enzym transcript level furthermor found exogen applic aa affect non photochem quench npq photoinhibit result chang diadinoxanthin dd diatoxanthin dt cycl thus play import role photoprotect
|
D017377
|
T204
|
36,286,466
|
antimicrobi secondari metabolit mangrov plant asia pacif microb white spot syndrom virus account sever loss shrimp farm industri global review examin literatur mangrov plant asia pacif antibacteri antifung antivir activ avail data publish subject collect googl scholar pubm scienc direct web scienc chemspid pubchem librari search plant speci exhibit antimicrobi effect total antimicrobi natur product identifi includ mic valu gml plant medicin mangrov plant asia pacif yield secondari metabolit potenti mitig infecti diseas shrimp aquacultur
|
D000935;D001688
|
T121;T195;T123
|
36,286,465
|
tetrahydrofuran motif marin lipid terpen heterocycl particular common moieti within marin natur product specif tetrahydrofuranyl ring present varieti compound present complex structur interest biolog activ focus terpenoid high number tetrahydrofuran contain metabolit isol last decad show promis biolog activ make potenti lead novel antibiot antikinetoplastid drug amoebicid substanc anticanc drug thus attract attent synthet communiti numer approach total synthes appear offer reader overview marin deriv terpenoid relat compound isol structur determin special focus total synthes biolog profil
|
D001688;D000970
|
T123;T121;T109
|
36,286,464
|
new ceramid cerebrosid deep sea far eastern starfish ceramast patagonicus three new ceramid three new cerebrosid along three previous known cerebrosid ophidiocerebrosid c ce isol deep sea starfish speci orang cooki starfish ceramast patagonicus structur amp nbsp determin nmr esim techniqu also chemic transform ceramid contain iso c c phytosphingosin long chain base c c r hydroxi fatti acid normal type cerebrosid contain c sphingosin anteiso type long chain base r hydroxyheptadecano acid normal type compound contain satur c phytosphingosin anteiso type long chain base differ length polymethylen chain r hydroxi fatti acid normal type c c new cerebrosid glucopyranos monosaccharid residu composit neutral sphingolipid c patagonicus describ first time investig compound exhibit slight moder cytotox activ human cancer cell ht sk mel mda mb normal embryon kidney cell hek compound concentr inhibit coloni format mda mb cell respect coloni inhibit activ compound compar effect doxorubicin reduc number coloni concentr
|
D002554;D002518
|
T121;T123;T109
|
36,286,463
|
toward sustain medicin resourc marin soft coral aquacultur insight chemic divers biolog potenti recent decad aquacultur techniqu soft coral made remark progress term condit product research abl obtain larger quantiti soft coral thus larger quantiti biolog activ metabolit allow studi biolog activ mani pharmacolog assay even produc suffici quantiti clinic trial review summar secondari metabolit identifi cultur soft coral era septemb various type diterpen eunicellin cembran spatan norcembran briaran aquarian well biscembran sterol quinon discov subject bioactiv investig differ studi also introduc depth discuss potenti biolog effect anti cancer anti inflammatori anti microbi mechan action identifi secondari metabolit hope review shed light untap potenti applic aquacultur produc valuabl secondari metabolit tackl current emerg health condit
|
D037421;D004224
|
T204;T109
|
36,286,462
|
anti inflammatori antioxid properti malapterurus electricus skin fish methanol extract arthrit rat therapeut protect effect protect therapeut anti inflammatori antioxid potenc malapterurus electricus f malapterurida skin fish methanol extract fe mgkgbwtday day oral test monosodium urat msu induc arthrit wistar albino male rat joint serum uric acid tnf il nf b mda gsh catalas sod glutathion reductas level measur accord find fe signific reduc uric acid level ankl swell protect therapeut group furthermor anti inflammatori effect downregul inflammatori cytokin primarili decreas oxid stress increas antioxid status aforement lesion signific improv protect treat rat fe accord histopatholog find ino immunostain reveal protect treat arthrit rat fe weak posit immun reactiv cell phytochem analysi reveal fe high fatti amino acid abund compound vaccen octadeceno palmit stearic acid glycin mg mg alanin mg mg extens molecular model dynam simul experi reveal compound potenti target inhibit cox isoform higher affin cox result contend fe could promis protect therapeut option arthriti aid prevent progress chronic inflammatori diseas
|
D000975;D014527
|
T123;T121;T109;T114;T039;T044
|
36,286,461
|
fucoidan brown alga comparison sulfat polysaccharid fucus vesiculosus ascophyllum nodosum prepar sulfat polysaccharid obtain brown alga known fucoidan biopolym attract consider attent due mani biolog activ may find practic applic two atlant repres phaeophycea name fucus vesiculosus ascophyllum nodosum belong order fucal popular sourc commerci fucoidan often regard similar chemic composit biolog action nevertheless two fucoidan prepar polysaccharid mixtur differ consider amount chemic natur compon henc circumst taken account investig biolog properti structur activ relationship spite differ fraction care character structur prepar fucoidan may valuabl applic drug develop
|
D044646;D044645;D000459
|
T002;T204
|
36,286,460
|
aminopyrimidon aminoimidazol alkaloid rodrigu calcar marin spong ernsta naturali chemic studi ch cl meoh extract spong ernsta naturali collect rodrigu mauritius base molecular network derepl strategi highlight one novel aminopyrimidon alkaloid compound ernstin seven new aminoimidazol alkaloid compound phorbatopsin e calcaridin c naamin h naamidin j k along known thymidin structur establish spectroscop analysi nmr spectra hresim data improv investig unstudi calcar marin spong metabolom studi molecular network conduct isol molecul distribut two cluster interest naamin naamidin deriv group togeth ernstin first cluster twenti three molecul phorbatopsin deriv calcaridin c group togeth cluster twenti one molecul interpret msms spectra compound cluster structur featur close isol one allow us propos structur hypothesi compound known potenti new
|
D011161;D000470
|
T123;T121;T109;T131;T204
|
36,286,459
|
isol synthesi absolut configur pericharaxin b epimer hydroxi polyen glycerol ether calcarean spong pericharax heteroraphi natur occur epimer hydroxi polyen glycerol ether pericharaxin b b isol calcarean spong pericharax heteroraphi structur stereochem character diastereoisom establish basi spectroscop data analysi total synthesi seven step mixtur pericharaxin b b proven epimer chiral phase hplc analysi synthet natur sampl separ epim applic mosher method synthet compound allow unequivoc absolut configur assign natur product synthet intermedi shown non cytotox hct cell line endochondr differenti activ use human type x collagen transcript activ atdc cell interest
|
D011161;D001688
|
T123;T121;T204
|
36,286,458
|
marin biotoxin whole process scallop argentin sea harm algal bloom increas worldwid threat seafood industri human health consequ natur product biotoxin accumul shellfish argentin sea identifi issu offshor fisheri patagonian scallop zygochlami patagonica lead potenti harm effect consum assess spatial tempor pattern marin biotoxin concentr patagonian scallop harvest argentinian water base analys paralyt shellfish toxin lipophil toxin amnes shellfish toxin evid concentr lipophil amnes toxin regulatori accept threshold trace concentr pectenotoxin azaspiracid okada acid group toxin confirm convers paralyt shellfish toxin quantifi scallop gonyautoxin domin unusu toxin profil term saxitoxin equival maximum concentr reach g stx eqkg chang profil link part season chang total toxin concentr compar sampl adductor muscl whole tissu result show absenc toxin adductor muscl confirm toxin accumul digest tract scallop absenc human health threat follow process scallop adductor meat find highlight paralyt shellfish toxin unusu toxin profil occur relat high concentr whole patagonian scallop specif region particular time period also show process scallop board factori ship obtain frozen adductor muscl effect manag process minim risk poison final product destin human consumpt
|
D008387;D049897
|
T131;T116;T204
|
36,286,457
|
vivo studi evalu efficaci blue shark prionac glauca cartilag collagen cosmet blue shark prionac glauca class chondrichthy pelag shark speci common found tropic temper ocean shark main sold asian countri food tradit chines medicin accord red list intern union conserv natur p glauca classifi low risk near endang p glauca cartilag contain collagen type ii make suitabl bioactiv ingredi cosmeceut product studi evalu effect gel contain various concentr lyophil hydrolyz p glauca cartilag human inner wrist skin compar placebo base skin properti evalu test conduct appli various concentr p glauca cartilag gel min inner wrist particip use skin analyz determin moistur level oil level textur level complexion level level ad lyophil hydrolyz shark cartilag lhsc signific improv moistur textur complexion skin control oil provid wrinkl smooth effect result indic lhsc formul prepar differ concentr signific enhanc effect skin hydrat elast textur smooth wrinkl level lhsc also effect control oil secret complexion
|
D000068937;D003358;D012754
|
T073;T167;T013
|
36,286,456
|
total synthesi biolog evalu modifi ilamycin deriv ilamycinsrufomycin marin cycloheptapeptid contain unusu amino acid produc streptomyc sp compound show potent activ rang mycobacteria includ multidrug resist strain mycobacterium tuberculosi cyclic peptid target aaa protein clpc togeth peptidas clppclpp form essenti atp driven proteas deriv ilamycin simplifi tryptophan unit synthes straightforward manner ilamycin deriv cyclic hemiamin structur activ nm rang sever mycobacteri strain show signific cytotox contrast deriv glutam acid posit signific less activ mic mid rang detail investig mode action indic deregul clpc activ strong enhanc clpc wt atpas activ consequ clpc proteolyt activ substrat specif suggest dual effect clpc wt function posit effect relat clpc wt atpas activ negat competit substrat bind clpc ntd
|
D001426;D009169
|
T123;T007;T116
|
36,286,455
|
vivo anticoagul antithromb activ depolymer glycosaminoglycan apostichopus japonicus dynam effect exposur relationship rat plasma glycosaminoglycan apostichopus japonicus ahg depolymer fragment dahg anticoagul fucosyl chondroitin sulfat aim studi evalu anticoagul antithromb activ ahg dahg well reveal dynam relationship exposur effect vivo result demonstr ahg mw kda dahg mw kda dahg mw kda exhibit potent anticoagul activ inhibit intrins factor xase complex fxase well antithrombin depend factor iia fiia factor xa fxa glycosaminoglycan mark prevent thrombosi format thrombin induc platelet aggreg dose molecular weight depend manner vitro vivo bleed time measur indic dahg exhibit obvious lower hemorrhag risk nativ ahg follow oral administr dahg could absorb blood dose depend prolong activ partial thromboplastin time aptt thrombin time tt well inhibit fxa fiia partial fxase anticoagul activ posit associ plasma concentr follow oral administr dahg studi propos new point view understand correl effect exposur fucosyl chondroitin sulfat effect safe oral antithrombot agent
|
D000925;D047528
|
T121;T204
|
36,286,454
|
molecular network guid catalog secondari metabolom select egyptian red sea soft coral soft coral recogn abund sourc divers secondari metabolit uniqu chemic featur physiolog capabl howev discoveri metabolit usual hinder tradit protocol requir larg quantiti live tissu isol spectroscop investig order overcom problem untarget metabolom protocol develop latter appli studi chemodivers common egyptian soft coral speci use minut amount coral biomass spectral similar network base high resolut tandem mass spectrometri data employ explor highlight metabol biodivers nine egyptian soft coral speci speci specif metabolit highlight futur priorit soft coral speci ms guid chemic investig overal metabolit tentat assign encompass diterpen sesquiterpen sterol simultan methodolog assist shed light newli overlook chemic divers potenti undescrib scaffold instanc glycosyl fatti acid nitrogen aromat compound polyketid propos sinularia leptoclado alkaloid terpen n acyl amino acid propos sarcophyton roseum sarcophyton acutum
|
D037421;D004224;D012717;D061065
|
T121;T204;T109
|
36,286,453
|
compar studi anti obes effect dietari sea cucumb saponin energi restrict respons weight loss weight regain mice dietari supplement sea cucumb saponin calori restrict prove effect allevi obes differ anti obes effect sea cucumb saponin energi restrict weight loss weight regain still unknown present studi high fat induc obes mice random divid three group includ high fat diet group hf energi restrict group hf l sea cucumb saponin group hf compar effect dietari sea cucumb saponin energi restrict weight glucos lipid metabol obes mice weight loss weight regain result show dietari sea cucumb saponin limit energi intak weight loss effect interest sea cucumb saponin could allevi impair glucos toler insulin resist caus obes addit inhibit srebp c mediat lipogenesi might lead allevi weight regain resum high fat diet even sea cucumb saponin longer supplement contrast limit energi intak tend promot lipid synthesi liver white adipos tissu restor high fat diet inflamm also induc find indic sea cucumb saponin could replac calori restrict prevent obes might use function food drug resist obes relat diseas caus obes
|
D012616;D012503
|
T204;T109
|
36,286,452
|
network pharmacolog analysi red sea spong hyrtio erectus extract reveal anticanc efficaci correspond load niosom studi lc hrms assist chemic profil hyrtio erectus spong led annot eleven major compound h erectus deriv crude extract test vitro antiprolif activ three human cancer cell line hep g human liver cancer cell line mcf breast cancer cell line caco colon cancer cell line encapsul within niosom hyrtio erectus extract show moder vitro antiprolif activ toward studi cell line ic valu respect formul extract contain niosom size nm pdi zeta potenti increas vitro antiprolif activ entrap extract signific ic respect subsequ comput chemic studi perform build spong metabolit target cancer diseas network focus target possess anticanc activ toward three cancer type breast colon liver pubchem bindingdb disgenet databas use build network shinygo kegg databas addit funrich softwar use gene ontolog function analysi comput analysi link metabolit gene among gene relat cancer gene intersect three cancer type studi prove co occurr compound probabl compound possess cytotox activ due larg number connect intersect cytotox gene edg rang target possess anticanc effect pathway cancer endocrin resist proteoglycan cancer mention kegg shinygo databas studi introduc niosom promis strategi promot cytotox potenti h erectus extract
|
D000970;D008081
|
T121;T109
|
36,286,451
|
therapeut potenti microalga deriv bioactiv metabolit influenc differ larg scale cultur strategi microalga identifi one promis sourc novel bioactiv compound biomed applic food industri cosmet last decad sever biotechnolog develop facilit identif grow number compound well studi optim microalga cultur condit product biomass enrich specif molecul interest studi two common commerci marin microalga nannochloropsi oculata porphyridium purpureum cultur standard nutrient stress condit obtain biomass extract assess potenti inhibit cancer cell prolifer migrat well antioxid activ result viabil cancer cell model show enhanc antitumour activ p purpureum model compar togeth greater capac reduc migrat capac cancer cell biomass nutrient stress condit wherea antioxid activ n oculata decreas expos nutrient stress condit date one studi prove control chang larg scale cultur condit nutrient deplet relev impact bioactiv biomass cancer cell
|
D058086;D044665
|
T002;T204
|
36,286,450
|
bioactiv peptid skipjack tuna cardiac arteri bulb prepar identif antioxid activ stabil thermal ph simul gastrointestin digest treatment cardiac arteri bulb skipjack tuna katsuwonus pelami rich elastin hydrolys high qualiti raw materi daili cosmet order effect util skipjack tuna process byproduct cardiac arteri bulb prepar peptid high antioxid activ pepsin select six proteas hydrolyz protein best hydrolysi condit pepsin optim use ultrafiltr chromatograph method eleven antioxid peptid purifi protein hydrolys tuna cardiac arteri bulb four tripeptid qgd pkk gpq gln identifi well seven pentapeptid geqsn geegd yeggd geger gegqr gpglm gdrgd three name tripeptid pkk pentapeptid yeggd gpglm exhibit highest radic scaveng activ diphenyl picrylhydrazyl dpph hydroxyl azino bis ethylbenzothiazolin sulfon acid abt superoxid anion assay also show protect plasmid dna hepg cell h induc oxid stress furthermor exhibit high stabil temperatur rang c ph valu rang simul gastrointestin digest min result suggest prepar eleven antioxid peptid cardiac arteri bulb especi three peptid pkk yeggd gpglm could serv promis candid health promot product due high antioxid activ stabil
|
D000975;D011492
|
T123;T121;T116;T039;T044
|
36,286,449
|
marin compound mitochondria malign therapeut nexus marin environ import yet general underexplor contain new sourc function constitu affect various pathway food process storag fortif bioactiv secondari metabolit produc marin microorgan may signific potenti applic human various compon isol dispar marin microorgan includ fungi microalga bacteria myxomycet show consider biolog effect anticanc antioxid antivir antibacteri neuroprotect activ grow studi reveal potenti anticanc effect marin agent could achiev modul sever organell mitochondria known organell influenc growth differenti death cell via influenc biosynthet bioenerget various signal pathway relat oxid stress cellular metabol consequ mitochondria play essenti role tumorigenesi cancer treatment adapt alter environment cellular condit grow interest marin deriv anticanc agent combin develop progress novel technolog extract cultur marin life led revel new compound meaning pharmacolog applic first critic review marin deriv anticanc agent potenti target mitochondri function tumorigenesi studi aim provid promis strategi cancer prevent treatment
|
D000970;D009369;D001688
|
T121;T191;T123;T109
|
36,286,448
|
new perspect reveal algicid properti bacillus subtili alexandrium pacificum bacteri communiti toxin algicid bacteria import control toxic dinoflagel bloom studi environment behavior relat algal toxin still lack studi bacillus subtili show highest algicid activ alexandrium pacificum group iv six bacillus strain treat v v bacteri cultur steril supernat algicid rate h respect algicid substanc secret consid mechan algicid effect algicid process rapid prolifer alteromona sp phycospher pacificum may acceler algal death moreov algicid develop releas larg amount intracellular paralyt shellfish toxin psts water extracellular psts increas h compar treatment bacteri cultur steril supernat h respect although total amount psts increas slight total toxic algal sampl decreas gtx transform gtx gtx result comprehens reveal complex relationship algicid bacteria microalga provid potenti sourc biolog control harm algal bloom toxin
|
D004141;D020591;D014118
|
T123;T007;T131;T204
|
36,286,447
|
growth factor free vascular marin origin collagen spong use cryopreserv stromal vascular fraction human adipos tissu success integr transplant three dimension tissu engin te construct depend great rapid vascular therefor essenti address vascular issu initi design construct perfus tissu two import variabl regard scaffold composit cell sourc collagen marin origin overcom issu associ mammal deriv collagen maintain advantag term biocompat concurr fresh isol stromal vascular fraction svf adipos tissu propos advantag cell fraction vascular purpos due high angiogen properti allow extrins angiogen growth factor free vascular strategi te applic studi aim understand whether marin collagen matric could support cryopreserv human svf maintain intrins angiogen properti observ fresh svf cryopreserv human svf seed blue shark collagen spong cultur day basal medium secretom profil sever angiogenesi relat factor studi throughout cultur time correl express pattern cd cd show format prevascular network upon ovo implant increas vessel recruit observ prevascular spong compar spong without svf cell immunohistochemistri cd demonstr improv integr prevascular spong within chick chorioalanto membran cam tissu situ hybrid show human cell line blood vessel result demonstr potenti use cryopreserv svf combin marin collagen streamlin approach improv vascular te construct
|
D000090002;D000273
|
T201;T024;T031
|
36,286,446
|
intratympan administr dieckol prevent ototox hear loss system administr dieckol report amelior acut hear loss studi dieckol deliv inner ear intratympan rout function anatom effect safeti dieckol assess use rat ototox model
|
D002945;D034381
|
T033;T121;T197;T047
|
36,286,445
|
nitrogen starvat enhanc product satur unsatur fatti acid aurantiochytrium sp pku sw regul key biosynthet gene nitrogen depriv known improv lipid accumul microalga thraustochytrid howev pattern fatti acid product molecular mechan under accumul unsatur satur fatti acid sfas nitrogen starvat remain larg unknown thraustochytrid studi batch cultur experi nitrogen replet nitrogen starvat condit perform chang transcriptom aurantiochytrium sp pku sw strain condit investig result show improv yield total fatti acid tfas total unsatur fatti acid total sfas nitrogen starvat suggest nitrogen starvat favor accumul unsatur satur fatti acid pku sw howev nitrogen starvat result fold increas sfas wherea fold increas unsatur fatti acid observ indic disproportion increas group fatti acid fabd enoyl coa hydratas gene signific upregul nitrogen starvat support observ increas yield tfas gl gl furthermor pfa b gene involv polyketid synthas pks pathway signific upregul nitrogen starvat suggest increas express pfa b gene nitrogen starvat may one explan increas yield docosahexaeno acid fold overal studi advanc current understand molecular mechan underli respons thraustochytrid nitrogen depriv fatti acid biosynthesi
|
D009584;D058009
|
T123;T196;T204
|
36,286,444
|
seven new alkaloid isol marin flavobacterium tenacibaculum discolor sv marin flavobacterium tenacibaculum discolor sv proven promis produc bioactiv nitrogen contain heterocycl chemic investig amp nbsp discolor sv reveal seven new heterocycl includ six new imidazolium contain alkaloid discolin c h one pyridinium contain alkaloid dispyridin molecular structur compound elucid analysi nmr hr esi ms data furthermor enzymat decarboxyl tryptophan tyrosin tryptamin tyramin catalyz decarboxylas disa investig use vivo vitro experi antimicrobi activ isol compound evalu discolin c e exhibit moder activ gram posit bacillus subtili dsm mycobacterium smegmati atcc listeria monocytogen dsm staphylococcus aureus atcc mic valu rang gml gml
|
D000470;D000890;D002262
|
T123;T121;T116;T109;T131;T126
|
36,286,443
|
investig genotox potenti marin toxin c samt use vivo comet micronucleus assay contamin respons atyp toxic report mussel bizert lagoon northern tunisia last decad character c sphinganin analog mycotoxin c samt neurotoxin show common mous toxic symptom includ flaccid paralysi sever dyspnea follow rapid death hazard assess human health work aim evalu vivo genotox effect marin biotoxin use classic alkalin modifi fpg comet assay perform detect dna break alkali labil site well oxid base micronucleus assay use bone marrow detect chromosom genom damag c samt induc statist insignific increas dna tail intens dose duodenum spleen contrari liver percentag tail dna increas signific mid dose gkg bwd c samt affect number micronuclei bone marrow microscop observ liver show increas number mitosi hepatocyt cytoplasm clarif level studi confirm c samt induc dna damag liver evid effect caus dna oxid chromosom genom damag
|
D009183
|
T131;T109
|
36,286,442
|
carotenoid marin microalga antimelanoma agent melanoma cell high invas metastat tumor cell common express molecular alter contribut multidrug resist eg braf mutat convent treatment effect long term requir exhaust search new altern recent carotenoid microalga investig adjuv antimelanoma therapi due safeti accept clinic toler mani current use food supplement review compil sever studi show microalg carotenoid inhibit cell prolifer cell migrat invas well induc cell cycl arrest apoptosi various melanoma cell line mapk nf b pathway mmp apoptot factor frequent affect exposur microalg carotenoid fucoxanthin astaxanthin zeaxanthin main carotenoid investig vitro vivo experiment model preclin data indic compound exhibit direct antimelanoma effect also capabl restor melanoma cell sensit convent chemotherapi eg vemurafenib dacarbazin
|
D058086;D008545;D000970
|
T121;T191;T204;T109
|
36,286,441
|
epigenet manipul induc product immunosuppress chromon cytochalasin mangrov endophyt fungus phomopsi asparagi dhs mangrov endophyt fungus phomopsi asparagi dhs found particular product regard accumul substanti new compound previous studi order explor potenti produc unobserv secondari metabolit epigenet manipul use fungus activ cryptic silent gene use histon deacetylas hdac inhibitor sodium butyr dna methyltransferas dnmt inhibitor azacytidin aza base coloni growth dri biomass hplc h nmr analys fungal chemic divers profil signific chang compar control two new compound name phaseolorin j phomoparagin along three known chromon six known cytochalasin isol cultur treat sodium butyr structur includ absolut configur elucid use combin detail hresim nmr ecd c nmr calcul immunosuppress cytotox activ isol compound evalu compound moder inhibit prolifer cona concanavalin induc lps lipopolysaccharid induc b murin spleen lymphocyt compound exhibit signific vitro cytotox test human cancer cell line hela hepg compar posit control adriamycin fluorouracil find demonstr epigenet manipul effici strategi induct new metabolit mangrov endophyt fungi
|
D003572;D002867
|
T123;T121;T109
|
36,286,440
|
bacteria associ benthic invertebr extrem marin environ promis underexplor sourc biotechnolog relev molecul microb invertebr associ common occur natur play fundament role life symbiont even hostil habitat assum key import ecolog evolutionari studi relev biotechnolog extrem environ emerg new frontier natur product chemistri search novel chemotyp microbi origin signific biolog activ howev date main focus microb sediment seawat wherea associ biota receiv signific less attent review therefor conceiv summar main inform invertebr bacteria associ establish extrem marin environ brief overview current known extrem marin environ main characterist report associ extremophil microorgan macrobenth organ hostil habitat provid second part review deal biotechnolog relev bioactiv molecul involv establish maintain symbiot associ
|
D007448;D001688
|
T123;T121;T204
|
36,286,439
|
evalu magnesium phosphat particl incorpor co electrospun chitosan elastin membran skin wound heal major challeng face clinician treat burn wound lack integr treatment wound inadequ mechan properti treatment high infect rate ultim lead poor wound resolut electrospun chitosan membran escm gain popular use tissu engin applic due drug load abil biocompat biomimet fibrous structur antimicrobi characterist work aim modifi escm improv perform burn wound applic incorpor elastin magnesium phosphat particl mgp improv mechan bioactiv properti follow escm made evalu individu compon effect c chitosan ce chitosan elastin cmg chitosan mgp cemg chitosan elastin mgp membran properti analyz fiber size structur hydrophil properti elastin incorpor mgp incorpor vitro releas mechan properti degrad profil vitro cytocompat niht fibroblast addit elastin mgp increas averag fiber diamet ce nm cmg nm cemg nm compar c nm water contact angl analysi show elastin incorpor membran ce cemg increas hydrophil compar group c cmg result degrad studi show mass retent c cmg group compar seen ce cemg week lysozymepb solut cmg cemg exhibit burst releas behavior gml mm magnesium within h vitro analysi niht fibroblast show ce cemg group superior cytocompat compar c cmg work demonstr success incorpor elastin mgp escm allow futur studi burn wound applic
|
D000890;D002056;D048271;D057139
|
T121;T073;T037;T109
|
36,286,438
|
caspas cathepsin b inhibitor marin invertebr aim reduct neuroinflamm neuroinflamm condit associ sever type dementia alzheim diseas ad main caus inflammatori respons amyloid peptid induc microgli activ subsequ cytokin releas neuron caspas inflammasom cathepsin b key enzym mediat neuroinflamm ad therefor reveal new molecul modul enzym may interest approach treat neurodegen diseas studi search new caspas cathepsin b inhibitor five speci brazilian marin invertebr four cnidarian one echinoderm result show extract box jellyfish chiropsalmus quadrumanus inhibit caspas extract fraction product monitor inhibitori activ obtent pure molecul identifi trigonellin mass spectrometri moreov four extract inhibit cathepsin b exaiptasia diaphana select subsequ fraction character result identif betain respons inhibitori action molecul alreadi found marin organ howev first studi show potent inhibitori effect caspas cathepsin b activ therefor new prototyp consid enzym inhibit subsequ control neuroinflamm
|
D002401;D000544
|
T047;T126;T116;T048
|
36,286,437
|
come new age marin glycom fundament medic ecolog aspect special issu marin glycom https wwwmdpicomjournalmarinedrugsspecialissuesmarineglycom access septemb provid new approachesand inform bioactiv compound glycan lectin marin anim seawe microorgan applic clinic therapi elucid thephysiolog function marin organ
|
D054794;D037102
|
T090;T116;T123
|
36,286,436
|
vitro modul complement activ therapeut prospect analogu marin polychaeta arenicin peptid widespread resist antibiot pathogen bacteria make develop new generat antimicrobi urgent task develop new antibiot must accompani comprehens studi biolog activ order avoid advers side effect applic promis antibiot prototyp deriv structur arenicin antimicrobi peptid lugworm arenicola marina develop previous describ abil natur arenicin modul human complement system activ vitro regard seem import evalu effect therapeut promis arenicin analogu complement activ describ complement modul activ three analogu ar vr alp aa found mode action ar vr alp complement similar natur arenicin activ inhibit complement depend concentr howev ar vr behav predomin inhibitor show moder increas ca product altern pathway model enhanc classic pathway complement activ contrast action alp character mark increas complement activ classic pathway concentr rang gml time higher concentr gml peptid exhibit complement inhibitori effect characterist arenicin peptid aa like arenicin exhibit inhibitori effect complement concentr gml much less pronounc overal result suggest effect complement system taken account develop antibiot base arenicin
|
D011077
|
T204
|
36,286,435
|
quinoid pigment sea urchin scaphechinus mirabili strongylocentrotus intermedius biolog activ potenti applic review present literatur data histori discoveri quinoid compound biosynthesi biolog activ special attent paid descript quinoid pigment sea urchin scaphechinus mirabili famili scutellida strongylocentrotus intermedius famili strongylocentrotida marin environ consid one import sourc natur bioactiv compound extrem rich biodivers primari secondari mouth anim contain high concentr new biolog activ substanc mani signific potenti interest medic purpos quinon pigment product secondari metabol marin anim complex structur becom basi develop new natur product echinoid modul chemic interact possibl activ ingredi medicin prepar chemic compound high pharmacolog potenti isol describ marin organ three well known way naphthoquinon biosynthesi polyketid shikim mevalon polyketid pathway biosynthesi pathway various quinon shikim pathway main pathway biosynthesi naphthoquinon note quinoid compound plant anim synthes various way biosynthesi
|
D047269;D039282;D009285;D061065;D001688
|
T121;T123;T109;T204;T002
|
36,286,434
|
silico analysi bioactiv peptid produc underutil sea cucumb product bioinformat approach bioinformat tool wide use predict potent bioactiv peptid food deriv materi studi focus util sea cucumb process product generat antioxid ace inhibitori peptid applic rang silico techniqu identifi peptid use lc msms virtual screen peprank techniqu follow silico proteolysi simul repres digest enzym use biopep uwm tm data base tool result peptid simul digest evalu toxic use toxinpr softwar digest resist peptid found non toxic display favor function properti indic potenti use wide rang food applic includ hydrophob hydrophil system identifi peptid assess medicin characterist employ swissadm web base applic find provid insight potenti use undervalu sea cucumb process discard function food product develop natur pharmaceut ingredi attribut oral drug discoveri process
|
D019295;D012616
|
T091;T204
|
36,286,433
|
krill oil inhibit cholesterol synthesi stimul cholesterol excret hypercholesterolem rat present studi aim investig antihypercholesterolem effect krill oil supplement high cholesterol diet induc hypercholesterolem rat mechan under effect rat divid five group normal control control high cholesterol diet krill oil mgkg bw high cholesterol diet krill oil mgkg bw krill oil mgkg bw high cholesterol diet krill oil mgkg bw week rat sacrif observ effect krill oil cholesterol synthesi excret found krill oil supplement suppress total triglycerid total cholesterol ldl cholesterol level well hmg coa reductas activ stimul ampk phosphoryl ldl receptor acat express liver fecal output cholesterol furthermor decreas level p selectin svcam well aortic wall thick demonstr role prevent atherosclerosi thus suggest krill oil supplement reduc ldl cholesterol level blood hypercholesterolemia stimul uptak ldl cholesterol tissu cholesterol excret well inhibit cholesterol synthesi
|
D033201;D006937;D006949
|
T033;T047;T204
|
36,286,432
|
depth understand ecklonia stolonifera okamura review bioactiv bioactiv compound ecklonia stolonifera okamura es main distribut coastal area middl pacif around korea japan long stand edibl valu rich various compound polysaccharid fatti acid algin acid fucoxanthin phlorotannin among polyphenol compound phlorotannin main activ ingredi studi shown extract activ compon es exhibit anti cancer antioxid anti obes anti diabet antibacteri cardioprotect immunomodulatori pharmacolog properti vivo vitro although es contain varieti bioactiv compound wide known extens studi base potenti health benefit expect play import role improv nutrit valu food econom medic therefor es need better understood develop util develop applic marin medicin function food bioactiv substanc mani field review provid comprehens overview bioactiv bioactiv compound es promot depth research refer comprehens util es futur
|
D000975;D000459
|
T123;T121;T204;T039;T044
|
36,286,431
|
nanoformul seawe eisenia bicyc albumin nanoparticl target cardiovascular diseas vitro vivo evalu natur product especi deriv seawe start seen effect various diseas cardiovascular diseas cvds studi aim design novel oral formul bovin albumin serum nanoparticl bsa nps load extract eisenia bicyc valid benefici health effect particular target hypercholesterolemia cvd prevent small well defin bsa nps load eisenia bicyc extract success prepar exhibit high encapsul effici antioxid activ cholesterol biosynthesi enzym hydroxi methylutaryl coenzym reductas hmgr inhibit well reduct cholesterol permeat intestin line model cell assess extract free nanoformul form nanoformul effici free extract particular term hmgr inhibit cholesterol permeat reduct vitro cytotox vivo assay wistar rat perform evalu safeti overal effect metabol result demonstr eisenia bicyc extract bsa nps cytotox human intestin caco liver hepg cell also safe oral administr rat model addit innov approach adopt compar metabolom profil serum anim involv vivo assay show extract nanoformul impact cvd associ key metabolit altogeth preliminari result reveal seawe extract nanoformul may constitut altern natur dosag form safe simpl produc capabl reduc cholesterol level consequ help prevent hypercholesterolemia main risk factor cvds
|
D012624;D002318;D006937;D000459;D053758;D001688
|
T123;T121;T073;T204;T047
|
36,286,430
|
vitro anti inflammatori activ fucoidan five speci brown seawe studi aim compar anti inflammatori effect fucoidan brown seawe saccharina japonica sj fucus vesiculosus fv fucus distichus fd fucus serratus fs ascophyllum nodosum determin relationship composit biolog activ anti inflammatori activ test vitro believ inflamm could trigger free radic fucoidan f vesiculosus fv fv show strongest diphenyl picrylhydrazyl dpph radic scaveng activ ic mgml total antioxid capac tac test activ concentr depend notabl tac fucoidan except sampl fv sj lower phenol content higher phloroglucinol tac fucoidan strong posit correl polyphenol content weak correl associ xylos content synergist effect fucoidan calcul first time use carbohydr polyphenol model mixtur synergi dpph test found fv fv mixtur effect respect strong posit correl polyphenol relationship fucos content posit moder first establish anti inflammatori effect fucoidan could mediat via inhibit protein denatur inhibit concentr depend strong correl fucos content moder sulfat content purifi fucoidan fv show promis activ ic mgml vs ic mgml diclofenac sodium similar relat also observ membran protect model fucoidan abl stabil cell membran integr human red blood corpuscl hrbc result studi support ration fucoidan use promis agent treatment inflammatori relat diseas via mechan radic scaveng antioxid activ inhibit protein denatur hrbc membran stabil
|
D000459;D012624;D044645
|
T002;T204
|
36,286,429
|
spong deriv bromin compound aeroplysinin impair endotheli inflammatori respons inhibit nf b pathway aeroplysinin apl bromin compound isol marin spong aplysina aerophoba exhibit pleiotrop bioactiv effect impair cell growth cancer cell inhibit angiogenesi vitro vivo modul redox status differ cell type among report activ addit aforement effect anti inflammatori potenti natur compound explor previous work laboratori mechan action under effect describ work delv anti inflammatori effect apl context vascular endotheli cell vitro provid new data regard molecular mechan under activ character mechan action point inhibitori effect apl nf b pathway one main axe involv endotheli respons inflammatori event result show apl inhibit express pro inflammatori gene tumor necrosi factor alpha tnf lipopolysaccharid lps stimul human umbil vein endotheli cell huvec target nuclear factor kappa b subunit nf b pathway mechan action involv inhibit kappa b kinas ikk complex phosphoryl relap nuclear import addit apl prevent phosphoryl akt induc tnf huvec probabl support inhibitori effect compound nf b pathway experiment evid report work open door potenti pharmacolog use compound anti inflammatori agent diseas cours patholog endotheli respons inflamm atherosclerosi
|
D016328;D011161
|
T129;T116;T204
|
36,286,428
|
uncommon capnosan diterpen neuroprotect potenti south china sea soft coral sarcophyton boettgeri first investig south china sea soft coral sarcophyton boettgeri afford five new capnosan diterpen sarboettgerin e togeth one known relat compound pavidolid structur includ absolut configur elucid extens spectroscop analysi c nmr calcul x ray diffract among new compound featur rare encount z geometri doubl bond within fuse bicycl capnosan carbon framework plausibl biogenet relationship isol propos might give insight futur biomimet synthesi novel compound vitro bioassay compound display potent anti neuroinflammatori activ lps induc releas bv microgli cell might develop new type potenti neuroprotect agent futur
|
D037421;D018696;D004224
|
T121;T169;T204;T109
|
36,286,427
|
scalaran sesterterpenoid isol marin spong hyrtio erectus cytotox eighteen scalaran sesterterpenoid includ eight new deriv isol spong hyrtio erectus famili thorectida extract show cytotox hela mcf cell line new deriv six compound found contain hydroxybutenolid moieti capabl revers stereoinvers hydroxyl carbon center influenc adjac function group deriv exhibit differ stereochem behavior fulli deduc roesi experi isol compound examin cytotox mts assay use staurosporin posit control ic hela mcf cell respect found show weak growth inhibitori activ hela mcf cell minim ic valu compound contain hydroxybutenolid moieti show cytotox ic valu rang potent deriv heteronemin although cytotox isol compound insuffici discuss structur activ relationship research could contribut expand structur divers scalaran understand stereochem behavior hydroxybutenolid
|
D011161;D000970
|
T121;T204;T109
|
36,286,426
|
identif character atp bind cassett transport chlamydomona reinhardtii microalga promis microorgan use produc valu ad product develop sustain approach environment remedi atp bind cassett protein abc chlamydomona reinhardtii character indispens transport co concentr mechan lipid biosynthesi heavi metal sequestr howev microalg abc protein studi compar higher plant non photosynthet microorgan studi perform genom wide evolutionari transcriptom survey c reinhardtii abc protein crabc total crabc identifi class eight abc subfamili abca abci found whole partial genom duplic event occur c reinhardtii ancient endosymbiosi event gene duplic occur small rang chromosom region forc abc famili expans abund light abscis acid jasmon acid respons cis element map crabc promot coincid evolutionari histori hormon signal chlorophyta express survey lightdark rhythm reveal close bond crabc cell divis develop broad studi crabc support expect role heavi metal detoxif lipid metabol environment adapt moreov evolutionari express survey predict function unknown crabc elabor text two half size crabcg crabcg crabcg describ plasma membran transport might particip lipid compound secret studi provid fundament exhaust inform crabc indispens function elucid abc protein microalga
|
D018528;D016825
|
T123;T116;T204
|
36,286,425
|
revalor microalga biomass synergist interact sustain applic bioplast generat microalga cyanobacteria photosynthet microorgan sourc renew biomass use bioplast product microorgan high growth rate contrari feedstock land crop requir arabl land addit use feedstock bioplast product compet food sourc eg corn wheat soy protein studi review macromolecul microalga cyanobacteria serv product bioplast includ starch glycogen polyhydroxyalkano phas cellulos polylact acid pla triacylglycerol tag addit focus cultiv microalga cyanobacteria wastewat treatment approach would allow reduc nutrient suppli biomass product treat wastewat thus combin wastewat treatment product biomass serv feedstock bioplast product discuss comprehens inform provid communic would expand scope interdisciplinari translat research
|
D058086;D054813;D000458
|
T007;T204;T109
|
36,286,424
|
altern solvent biorefineri spirulina impact pretreat free fatti acid high ad valu grow demand molecul interest microalg biomass phycobiliprotein led accumul unus product exampl phycocyanin obtain extract spirulina generat cake rich non polar molecul interest free fatti acid ffas ffas general consid marker lipidom degrad repres relev altern topic antibiot base biomimet approach order develop sustain spirulina biorefineri scheme differ pretreat altern solvent screen identifi best combin valor ffas thus five pre treatment studi includ phycocyanin extract product follow three biobas solvent select ethyl acet etoac dimethyl carbon dmc fatti acid base natur deep eutect solvent nade pigment fatti acid profil establish spectroscop chromatograph approach nade demonstr superior extract capac select compar biobas solvent regardless pretreat contrast etoac dmc show greater divers ffas predomin polyunsatur fatti acid pufa product also highlight relev raw materi facilit recoveri ffas result pave way green biorefineri lipid fraction phycobiliprotein microalga
|
D053545;D058086
|
T007;T204
|
36,286,423
|
compar studi docosahexaeno acid differ molecular form promot apoptosi non small cell lung cancer cell ppar depend manner cancer lead caus death worldwid grow evid shown docosahexaeno acid dha amelior effect cancer howev effect dha enrich phosphatidylcholin dha pc efficaci differ dha pc dha triglycerid dha tg dha ethyl ester dha ee cancer cell studi studi lung cancer cell vitro use determin effect under mechan dha differ molecular form result show dha pc dha tg treatment signific inhibit growth cell wherea dha ee signific effect morpholog analysi show dha pc dha tg prompt promot cell contract increas concentr cell heterochromatin vacuol cytoplasm edema endoplasm reticulum mitochondria tunel aoeb stain indic dha pc dha tg promot cell apoptosi dha pc perform better dha tg mechanist dha pc dha tg treatment regul ppar rxr signal inhibit express nf b bcl enhanc express bax caspas therebi promot cell apoptosi conclus dha pc exert superior effect dha tg dha ee promot apoptosi non small cell lung cancer cell data provid new evid applic dha treatment cancer
|
D002289;D008175
|
T191
|
36,286,422
|
algin base micro nanosystem target cancer therapi algin wide explor due salient advantag hydrophil biocompat mucoadhes featur bioavail environment benign properti cost effect appli design micro nanosystem control target drug deliveri cancer therapi algin biopolym find usag encapsul anticanc drug improv bioavail sustain releas pharmacokinet bio clearanc notabl nanomateri appli phototherm photodynam chemodynam therapi cancerstumor futur explor ought conduct find novel algin base nano system target cancer therapi use advanc drug deliveri techniqu benefit non invas patient complianc conveni drug administr thus critic paramet mucos permeabl stabil gastrointestin tract environ drug solubl ought consid addit comprehens clinic translat studi along optim synthesi techniqu still need address herein present overview current state knowledg recent develop pertain applic algin base micro nanosystem target cancer therapi base control drug deliveri phototherm therapi chemodynamicphotodynam therapi approach focus import challeng futur direct
|
D000464;D009369
|
T121;T122;T191;T109
|
36,286,421
|
cytotox n methylpretrichodermamid b reveal anticanc activ inhibit p glycoprotein drug resist prostat cancer cell n methylpretrichodermamid b nb biolog activ epidithiodiketopiperazin isol sever strain alga deriv fungus penicillium sp recent report first data activ human cancer cell line vitro investig activ select mechan action nb human prostat cancer cell line includ drug resist subtyp nb reveal cross resist docetaxel pc dr cell line model high activ hormon independ rv cell nb induc cell death stipul extern phosphatidylserin activ caspas moreov inhibit caspas activ z vad ome fmk affect nb cytotox suggest caspas independ cell death induc nb compound moder p glycoprotein p gp substrat like affin simultan inhibit p gp nanomolar concentr therefor nb resensit p gp overexpress pc dr cell docetaxel kinom profil nb treat cell reveal among thing induct mitogen activ protein kinas jnk p function analysi confirm activ kinas indic prosurviv role biolog event cellular respons treatment overal nb hold promis anticanc potenti structur activ relationship studi structur optim need order improv biolog properti
|
D000970;D011471
|
T121;T191;T109
|
36,286,420
|
potenti epiderm growth factor like peptid sea cucumb stichopus horren increas growth human cell silico molecular dock approach sea cucumb promin tradit remedi among asian wound heal due high capac regener expuls intern organ short peptid consist amino acid transcriptom data stichopus horren sh egfl show convinc capabl promot growth human melanoma cell molecular dock sh egfl peptid human epiderm growth factor receptor hegfr exhibit favor intermolecular interact sh egfl residu interact calcium bind like domain superimpos imag dock structur human egf egfr crystal model also gave accept root mean squar deviat rmsd valu less human cell growth signific improv sh egfl peptid lower concentr cell prolifer assay gene express profil cell indic sh egfl activ hegfr five epiderm growth factor signal pathway phosphoinositid kinas pik mitogen activ protein kinas mapk phospholipas c gamma plc gamma janus kinas signal transduc activ transcript jak stat ras homolog rho pathway pathway trigger cell prolifer differenti surviv organ actin cytoskeleton overal marin deriv bioactiv peptid capabl promot prolifer could explor cell growth promot agent biomed bioprocess applic
|
D047528;D012616
|
T204
|
36,286,419
|
cytotox potenti marin diatom thalassiosira rotula insight bioactiv methylen cholesterol marin microalga receiv great interest sustain sourc bioactiv metabolit health nutrit person care present studi bioassay guid screen allow identifi enrich fraction spe separ methanol extract marin diatom thalassiosira rotula chemic heterogen composit cytotox molecul includ pufa terpen phytol carotenoid fucoxanthin phytosterol methylen cholesterol mchol particular latter object deep investig aim gain insight mechan action activ two tumour cell model recognis resist chemic treatment breast mcf lung cell line result studi reveal mchol line studi sitosterol sit show cytotox activ rang concentr involv induct apoptosi cell cycl arrest although differ emerg two sterol two cancer system specif target investig caspas caspas fas trail
|
D017377;D010840
|
T123;T121;T204;T109
|
36,286,418
|
ocean sunfish mola spp tetraodontiform molida repres risk tetrodotoxin poison portugues coast tetrodotoxin ttx potent neurotoxin natur occur terrestri marin organ pufferfish due risk ttx poison fish tetraodontida famili puffer relat speci must place eu market restrict appli fish famili molida even though data toxin occurr avail studi presenc ttx analogu investig main edibl tissu white muscl main xenobiot storag organ liver ocean sunfish mola spp n south portugues coast hilic msms analys reveal ttx analyz sampl suggest inexist limit risk ttx poison
|
D023721
|
T013
|
36,286,417
|
unusu tetrahydropyridoindol contain tetrapeptid human nicotin acetylcholin receptor target activ discov antarctica deriv psychrophil pseudogymnoascus sp hdn chemic investig psychrophil fungus pseudogymnoascus sp hdn deriv antarctica led discoveri six new tetrapeptid psegymamid f whose planar structur elucid extens nmr ms spectrometr analys structur psegymamid f possess uniqu backbon bear tetrahydropyridoindol unit make first exampl discov natur occur peptid absolut configur structur unambigu determin use solid phase total synthesi assist marfey method compound evalu inhibit human h nicotin acetylcholin receptor subtyp compound show signific inhibitori activ preliminari structur activ relationship investig reveal tryptophan residu c termin methoxi group import inhibitori activ high bind affin compound h explain molecular dock studi
|
D011978;D001203
|
T004;T116;T192
|
36,286,416
|
fucoxanthin product microalga differ cultur factor systemat review fucoxanthin one light harvest pigment brown microalga increas gain attent due numer health promot properti current product microalg fucoxanthin yet feasibl econom perspect howev cultiv microalga favour condit hold great potenti increas viabil fucoxanthin sourc henc studi aim review fucoxanthin product microalga differ condit systemat literatur search perform use web scienc scopus pubm databas total articl download articl select current review two independ author microalga appear reliabl fucoxanthin sourc compar macroalga overal consensus fucoxanthin product condit obtain propos light intens rang molm could achiev higher fucoxanthin content howev optim light condit produc fucoxanthin speci specif current review serv anteced offer insight fucoxanthin produc microalga respons differ cultur factor via systemat analysi current find recommend feasibl produc fucoxanthin commerci could enhanc possibl achiev practic sustain fucoxanthin product
|
D058086
|
T204
|
36,286,415
|
phaeosphamid b cytotox cyclodecadepsipeptid mangrov deriv fungus phaeosphaeriopsi sp chemic examin ferment broth mangrov deriv fungus phaeosphaeriopsi sp result isol two new cyclodecadepsipeptid name phaeosphamid b well one known congen sch structur new metabolit includ absolut configur establish basi extens spectroscop data analys chemic convers marfey method hydroxi methylpentano acid hmp moieti pipecol acid pip unit structur rare discov natur interest compound exampl peptid discov fungal genus phaeosphaeriopsi first time identifi compound evalu cytotox five tumor cell line ag bel hepg b biu among compound show inhibitori activ tumor cell line ic valu rang mechanist investig found arrest ag cell g phase induc apoptosi dose depend manner
|
D000970;D001203
|
T121;T004;T109
|
36,286,414
|
fucoidan incorpor composit scaffold stimul osteogen differenti mesenchym stem cell bone tissu engin global million bone graft procedur perform clinician annual treat rise preval bone defect studi design fucoidan sargassum ilicifolium incorpor osteo induct scaffold compris calcium crosslink sodium algin nano hydroxyapatit nano graphen oxid alg ha go f tend serv bone graft substitut physiochem character includ ft ir xrd tga confirm structur integr materi sem afm reveal high suitabl surfac properti poros nanoscal rough incorpor go enhanc mechan strength alg ha go f find demonstr slower degrad improv protein adsorpt fucoidan load scaffold slow sustain releas fucoidan pbs h provid develop system ad advantag apatit format abil alg ha go f sbf solut predict scaffold osteointegr bone bond capabl vitro studi use cht reveal x time greater cell prolifer fucoidan load scaffold control result determin augment alkalin phosphatas miner activ physic structur enrich osteogen potenti result alg ha go f indic potenti bone graft substitut orthoped applic
|
D059630;D018786
|
T122;T025
|
36,286,413
|
ocellatuperoxid f uncommon anti tumor pyron peroxid photosynthet mollusk placobranchus ocellatus six new pair pyron polypropion enantiom unusu peroxyl bridg side chain name ocellatuperoxid f isol character south china sea photosynthet mollusk placobranchus ocellatus extens spectroscop analysi singl crystal x ray diffract analysi ecd electron circular dichroism comparison tddft time depend densiti function theori ecd comput use determin structur absolut configur new compound cell viabil assay sever compound show consider anti tumor effect human non small cell lung cancer cell gefitinib erlotinib posit control rna sequenc analysi gene express evalu indic anti tumor activ effect compound associ regul sever import gene fgfr hdac
|
D002289;D008175
|
T191
|
36,286,412
|
antimicrobi biosynthet potenti phylogenet analysi cultur bacteria associ spong ophlitaspongia sp yellow sea china spong deriv bacteria consid promis sourc novel drug owe abund secondari metabolit divers biolog activ studi explor antimicrobi biosynthet potenti phylogenet cultur bacteria associ spong ophlitaspongia sp yellow sea china use cultur depend method obtain bacteri strain analys antimicrobi activ seven indic strain result indic isol strain exhibit antimicrobi activ inhibit least one indic strain fifti two strain select phylogenet analysi use rrna gene sequenc well presenc polyketid synthas pks non ribosom peptid synthetas nrps gene strain belong genera famili phyla includ actinobacteria bacteroidet firmicut proteobacteria five strain pks gene ten strain nrps gene detect among two strain contain pks nrps gene notoacmeibact sp strain hma class alphaproteobacteria exhibit potent antimicrobi activ thus whole genom sequenc method use analys secondari metabolit biosynthet gene cluster genom hma contain biosynthet gene cluster potenti encod secondari metabolit belong compound class non ribosom peptid prodigiosin terpen lacton siderophor among other studi indic spong ophlitaspongia sp harbour divers bacteri strain antimicrobi properti may serv potenti sourc bioactiv compound
|
D048630;D011161
|
T126;T116;T204
|
36,286,411
|
total synthes propos structur iriomoteolid b synthesi three deriv structur studi iriomoteolid iriomoteolid b potent cytotox agent isol marin dinoflagel carri enantioselect synthes propos structur natur product howev analysi nmr spectra synthet iriomoteolid natur product reveal structur iriomoteolid iriomoteolid b assign incorrect base upon detail analysi spectral data synthet iriomoteolid natur product ration design three diastereom propos structur effort assign correct structur key step synthes propos structur iriomoteolid involv high diastereoselect ene reaction carbocupr util gilman reagent julia kocienski olefin coupl fragment yamaguchi macrolacton form target macrolacton synthet rout util carri synthes three diastereom propos structur diastereomer structur show close similar natur iriomoteolid howev differ spectral data natur iriomoteolid exhibit potent cytotoxici preliminari biolog evalu synthet iriomoteolid iriomoteolid b three synthet deriv show appreci cytotox properti
|
D018942;D001688
|
T121;T123;T109
|
36,286,410
|
enzym immobil metal organ framework effect buffer stabil support metal organ framework mof use encapsul array enzym rapid facil manner howev stabil mof support enzym examin detail studi examin stabil mof differ composit fe btc co tma ni tma cu tma zif zni buffer solut common use enzym immobil biocatalysi stabil assess via quantif releas metal induct coupl plasma optic emiss spectroscopi buffer use vari effect differ mof support incub mof buffer result releas metal ion vari extent fe btc complet dissolv citrat buffer profound destabil effect mof analyz preclud use mof mof stabl acet potassium phosphat tris hcl buffer result obtain provid guid select appropri buffer particular mof support immobil enzym addit result identifi requir develop method improv stabil mof aqueous solut use polym coat evalu polyacryl acid paa provid improv level stabil lipas immobil fe btc paa coat result stabl biocatalyst retent activ comparison free enzym
|
D000073396
|
T109
|
36,286,408
|
descend neuron popul dynam odor evok spontan limb depend behavior deciph brain regul motor circuit control complex behavior import long stand challeng neurosci fli drosophila melanogast coordin popul descend neuron dns activ dns known suffici drive complex behavior like walk groom howev addit role larger popul dns play natur behavior remain larg unknown exampl may modul core behavior command compris parallel pathway engag depend sensori context evalu possibl record popul near dns individu tether fli generat limb depend behavior includ walk groom found largest fraction record dns encod walk fewer activ head groom rest larg fraction walk encod dns encod turn far fewer weak encod speed although odor context determin behavior encod dns recruit dns encod odor rather behavior last illustr one identifi individu neuron dn popul record use spatial function morpholog properti result set stage comprehens popul level understand brain descend signal regul complex motor action
|
D004331;D009812
|
T120;T070;T204
|
36,286,404
|
icodextrin use feasibl periton dialysi patient undergo f fdg petct scan f fdg petct scan use diagnost tool patient neoplasia inflammatori diseas evalu due interfer glucos cellular uptak f fdg tracer via glucos transport withhold glucos sourc sever hour imag mandatori also case periton dialysi patient glucos contain periton dialysi fluid use prior f fdg petct scan whether hold true icodextrin known describ two patient metastat carcinoma periton dialysi icodextrin contain regimen icodextrin discontinu f fdg petct scan accur diagnosi metastat lesion well one case simultan tunnel infect could made observ suggest signific interfer icodextrin metabol f fdg feasibl continu establish icodextrin contain regimen periton dialysi patient case f fdg petct scan
|
D019788;D010530
|
T061;T130;T109
|
36,286,394
|
dri molten globul like intermedi protein fold function diseas perform protein depend correct fold final function nativ form henc understand process protein fold remain import field research scientif communiti past five decad two import intermedi state name wet molten globul wmg dri molten globul dmg emerg critic mileston protein fold unfold reaction much discuss wmgs common unfold intermedi evid dmgs remain elus owe near nativ featur make difficult probe use global structur probe review put togeth avail literatur new evid dmgs give broader perspect univers dmgs discuss signific protein fold function diseas
|
D017510;D058767
|
T044;T043
|
36,286,393
|
naphthalimid base fluoresc probe profil aldehyd oxid unsatur lipid lipophil naphthalimid hydrazin fluoresc probe success develop studi profil aldehyd oxid product dodecyl amin appli afford lipophil fluoresc probe lipid investig fluoresc properti probe condens product typic aldehyd includ mda hexan reveal signific enhanc fluoresc intens condens due inhibit photo induc electron transfer mda hexan could differenti probe emiss differ fluoresc color blue mda green hexan eight major oxid compon includ seven aldehyd detect fluoresc probe coupl high perform liquid chromatographi mass spectrometri aerob oxid typic unsatur lipid format aldehyd oxid product ration radic oxid mechan detect repres aldehyd product demonstr general applic fluoresc probe profil aldehyd lipid oxid
|
D005456;D053644
|
T130;T109
|
36,286,389
|
squar energi resolv mass spectrometri advanc quantit bile acid submetabolom character bile acid ba submetabolom partial reflect either physiolog patholog status vertebr structur divers howev extens hinder ba submetabolom clarif effort primarili devot enhanc structur annot confid bas particular conjug bas fortifi new technolog name squar energi resolv mass spectrometri er ms tradit liquid chromatographi tandem mass spectrometri lc msms possess two tandem space collis cell name q linear ion trap lit chamber qtrap ms employ fit purpos tool conduct er ms measur first er ms undertaken q cell gain first generat breakdown graph disclos conjug site via appli multipl reaction monitor mrm program second er ms accomplish lit chamber program mrm cube acquir second generat breakdown graph concern ion scaffold character authent ba librari consist commerci bas togeth vitro metabolit built record refer breakdown graph set moreov call univers metabolom standard sampl prepar pool divers ba enrich matric appli structur deciph potenti evalu quasi quantit analysi detect bas well accord appli well defin quasi content concept high confid structur analysi achiev mani bas signific impact occur ba submetabolom hepg cell lithochol acid treatment togeth er ms provid promis tool promot although limit lc msms base ba target metabolom
|
D001647;D053719
|
T063;T123;T109
|
36,286,261
|
use discret choic experi elicit prefer digit wearabl health technolog self manag chronic kidney diseas wearabl digit health technolog dhts potenti improv chronic kidney diseas ckd manag patient engag studi aim investig elicit prefer individu ckd toward wearabl dhts design support self manag condit
|
D000073278;D051436;D000076251
|
T058;T073;T047
|
36,286,260
|
protect omicron vaccin previous infect prison system inform regard protect confer vaccin previous infect infect b omicron variant sever acut respiratori syndrom coronavirus sar cov limit
|
D011330;D000086382
|
T047;T073;T067
|
36,286,256
|
earli activ mobil mechan ventil icu intens care unit icu acquir weak often develop patient undergo invas mechan ventil earli activ mobil may mitig icu acquir weak increas surviv reduc disabl
|
D012121;D004434
|
T061
|
36,286,250
|
methanol depend carbon fixat irrevers synthesi allulos xylos engin escherichia coli allulos rare hexos great applic potenti owe moder sweet low energi uniqu physiolog function current strategi allulos product whether industri develop util six carbon sugar glucos fructos substrat usual base principl revers izumor epimer work design novel rout coupl pathway methanol reduct pentos phosphat pp ribulos monophosph rump allulos monophosph aump escherichia coli irrevers synthes allulos xylos methanol improv express als sumo fusion regul carbon flux knockout frmrab rpia pfka pfkb titer allulos fed batch ferment reach mm yield mmmm xylos mmmm methanol
|
D014994;D004926
|
T123;T007;T109
|
36,286,248
|
environment investig legionellosi outbreak montrgi quebec canada august legionellosi outbreak involv person occur within meter radius montrgi region qubec canada near real time model wind direct along epidemiolog environment investig identifi possibl sourc model wind direct could help identifi like legionella pneumophila sourc legionellosi outbreak
|
D007876;D016952;D007877
|
T047;T007
|
36,286,246
|
serolog evid human exposur ehrlichiosi agent japan retrospect analys report febril patient japan seroconvers antibodi ehrlichia chaffeensi antigen detect use immunofluoresc western blot result provid evid autochthon human ehrlichiosi case indic ehrlichiosi consid potenti caus febril ill japan
|
D018469;D016873
|
T047;T007
|
36,286,232
|
presenc spirometra mansoni causat agent sparganosi south america report molecular identif adult spirometra mansoni tapeworm retriev crab eat fox cerdocyon thous colombia confirm presenc parasit south america tapeworm causat agent human sparganosi common report southeast asia repres second congener speci known zoonot potenti america
|
D013146;D013031;D002590
|
T047;T204
|
36,286,231
|
jamestown canyon virus collect mosquito main unit state jamestown canyon virus jcv mosquito born arbovirus circul north america detect jcv pool mosquito collect midcoast main usa phylogenet analysi jcv sequenc obtain aed cantat mosquito cluster within clade also circul connecticut usa
|
D002141;D009033;D001103;D000330
|
T005;T204
|
36,286,226
|
sequenc base identif metronidazol resist clostridioid difficil isol plasmid pcd metro confer metronidazol resist clostridioid difficil show high sequenc similar among pcd metro plasmid differ isol identifi pcd metro associ metronidazol resist isol clinic veterinari reservoir america recommend use pcr genom assay detect pcd metro metronidazol resist c difficil
|
D016360;D003015
|
T047;T007;T037
|
36,286,225
|
silent transcript interv translat burst lead divers phenotyp switch gene express bimod potenti mechan generat phenotyp cell divers enhanc surviv cell fluctuat environ previous studi shown intrins extrins regul could induc bimod gene express unclear whether bimod occur without regul develop interpret tractabl model name general telegraph model gtm consid silent transcript interv translat burst character general distribut use queu theori deriv analyt express protein distribut show non exponenti inact time translat burst lead two peak protein distribut away origin differ occur classic telegraph model also find silent interv nois translat burst size nois amplifi gene express nois induc divers dynam express pattern result provid altern mechan phenotyp switch also could use explain bimod phenomenon experiment observ
|
D005786
|
T045
|
36,286,224
|
seroincid enter fever juba south sudan appli new serosurveil tool estim typhoid salmonella burden use sampl collect popul juba south sudan use dri blood spot test found enter fever seroincid rate person year cumul incid year period
|
D014435;D010284
|
T047
|
36,286,223
|
cluster norovirus genogroup ix outbreak long term care facil utah usa report cluster acut gastroenter outbreak long term care facil utah usa link healthcar employe work multipl facil four outbreak caus norovirus genotyp gix recommend continu norovirus surveil genotyp determin contribut genotyp norovirus outbreak
|
D029322;D017250
|
T005;T047
|
36,286,195
|
polyclon dissemin oxa carbapenemas produc klebsiella pneumonia franc increas preval oxacillinas produc enterobacteral observ franc most driven emerg klebsiella pneumonia whole genom sequenc identifi oxacillinas produc k pneumonia belong sequenc type sts among polyclon high risk clone st st overrepres
|
D007710;D000073182
|
T047;T007
|
36,286,192
|
effect lower vs higher oxygen satur target surviv hospit discharg among patient resuscit hospit cardiac arrest exact random clinic trial administr high fraction oxygen follow return spontan circul hospit cardiac arrest may increas reperfus brain injuri
|
D058687;D016887;D000086382
|
T061;T047;T046;T067
|
36,286,084
|
associ extracorpor membran oxygen new mental health diagnos adult survivor critic ill extracorpor membran oxygen ecmo use temporari cardiorespiratori support critic ill patient littl known regard long term psychiatr sequela among survivor ecmo
|
D015199;D019966
|
T061;T033;T048
|
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