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biomedical-topic-categorization-validation

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36,342,801
myocardi uptak ga pentixafor patient system amyloidosi year old man present chest tight lower limb edema year laboratori imag examin suggest cardiac amyloidosi f fdg ga pentixafor petct show increas uptak myocardium left ventricl wherea bone marrow diffus mild uptak ga pentixafor without bone destruct mtc mdp bone scintigraphi also detect extraoss uptak heart gut kidney soft tissu biopsi abdomin subcutan fat confirm amyloid deposit patient final diagnos primari system amyloidosi case demonstr cardiac amyloidosi might show increas ga pentixafor uptak myocardium
D000072078;D000686
T060;T047
36,342,800
primari aortic epithelioid angiosarcoma metastat diseas detect f fdg petct epithelioid angiosarcoma aortic arch metastat diseas extrem rare report case year old man suspect bone metastas underw f fdg petct seek potenti primari tumor petct demonstr intens fdg uptak aortic arch multipl fdg avid lesion involv lung lymph node bone final diagnosi primari aortic epithelioid angiosarcoma metastat diseas confirm
D006394;D018323;D016609
T191
36,342,799
increas ga dotat uptak supraclavicular brown adipos tissu character brown adipos tissu bat f fdg uptak well report howev ga dota conjug somatostatin receptor target peptid uptak bat rare document herein report interest case increas ga dotat uptak supraclavicular bat young boy paroxysm hypertens low bodi mass index increas perfus bat respons cold may signific influenc factor
D002001;D019788
T130;T024;T109
36,342,798
primari neuroendocrin carcinoma pineal gland extens mening metastasi detect f notat petct primari neuroendocrin tumor pineal gland rare diseas year old woman right cerebellopontin angl metastat small cell neuroendocrin carcinoma underw f fdg f notat petct scan f notat petct show intens uptak pineal gland lesion multipl foci intens focus uptak intracrani leptomening whole spinal canal howev lesion less impress f fdg petct
D010870;D018278;D055756
T023;T191
36,342,797
mtc mip psma uptak isol paratrach lymph node prostat adenocarcinoma oncologist consult year old man receiv prostat specif antigen screen result prostat specif antigen level screen time ngml result poor differenti prostat adenocarcinoma gleason score diagnos spectct scan mtc mip psma tracer perform mtc psma posit lesion detect prostat extern iliac obtur lymph node pelvi para aortic right lower paratrach space patient prescrib androgen depriv therapi earli chemotherapi docetaxel fraction radiat therapi prostat semin vesicl plan
D011471;D000230
T191
36,342,796
ga dota fapi petct imag case radioact iodin induc chronic parot ga dota fapi promis pet agent tumor imag howev inflammatori lesion also show increas fapi uptak herein report year old woman underw total thyroidectomi thyroid papillari carcinoma year ago underw adjuv radioiodin therapi month later therapi began develop pain swell bilater cheek develop oral dryness patient diagnos radioact iodin induc parot ga dota fapi petct show densiti bilater parotid gland increas volum decreas intens tracer uptak mtco salivari gland scintigraphi show decreas tracer uptak bilater parotid gland
D010309;D013964
T047;T191
36,342,795
ga fapi f fdg petct imag patient rosai dorfman diseas liver involv rosai dorfman diseas rare non langerhan cell histiocytosi histopatholog character accumul cd posit posit histiocyt patholog chang most discov lymph node report case rosai dorfman diseas liver bone marrow involv case f fdg petct reveal fdg avid multipl lymph node liver bone marrow ga fapi petct show higher uptak ga fapi f fdg lesion find ga fapi petct patient highlight potenti valu ga fapi stage rosai dorfman diseas
D019788;D015618
T047;T130;T109
36,342,794
f fdg f fluciclovin uptak poor differenti lung adenocarcinoma set biochem recurr prostat adenocarcinoma year old man histori gleason ptcn prostat adenocarcinoma status post prostatectomi underw fluciclovin petct show tracer avid right upper lobe spicul solitari pulmonari nodul follow fdg petct show hypermetabol right upper lobe spicul solitari pulmonari nodul fine needl aspir consist primari lung adenocarcinoma subsequ right upper lobectomi perform poor differenti lung adenocarcinoma confirm
D003074;D008175;D000077192;D011471
T047;T191
36,342,793
manifest patient myelofibrosi ga dota fapi petct mimick super bone imag primari myelofibrosi chronic inflammatori diseas bone marrow progress earli robust inflammatori state advanc fibrot respons repres advanc stage diseas report year old woman diagnos primari myelofibrosi f fdg petct show mild uptak diffus sclerot lesion bone matrix wherea ga dota fapi show intens uptak whole skeleton
D000072078;D055728
T060;T191
36,342,792
divers pattern clinic signific c methionin pet dysembryoplast neuroepitheli tumor dysembryoplast neuroepitheli tumor dnet slow grow epilepsi associ tumor low normal c methionin met pet uptak help differenti dnet low grade glioma howev divers met pet uptak dnet observ aim studi measur clinic signific prognost valu met pet dnet manag
D005910;D001932
T191
36,342,777
systemat review acut emerg care intervent adolesc adult sever acut respiratori infect includ covid low middl incom countri sever acut respiratori infect sari remain lead caus death global particular low middl incom countri lmic earli intervent critic consid potenti rapid decompens patient sari aim evalu impact acut emerg care intervent improv clinic outcom patient year old sari lmic
D000086382;D007251;D004632
T061;T067;T093;T047;T058
36,342,768
investig patient continu intent toward convers agent outpati depart cross section field survey convers agent cas develop outpati depart improv physician patient communic effici end user patient continu intent essenti sustain develop cas
D033182;D010045
T101;T041
36,342,763
use smartphon keystrok dynam passiv monitor upper limb cognit function multipl sclerosi longitudin analysi type smartphon becom near daili activ requir upper limb cognit function analysi keyboard interact regular type keystrok dynam could therefor potenti util passiv continu monitor function patient multipl sclerosi
D000068997;D009103
T047;T073
36,342,760
healthcar older peopl africa africa poorest youngest popul region world set see rapid increas number older person come three decad expect increas preval non communic diseas alreadi evid spars data exist geriatr syndrom healthcar system vari consider countri univers healthcar avail hand public healthcar general underfund overburden unprepar care older person privat care unafford train geriatr medicin limit small number facil countri despit african union polici framework plan action age littl progress implement age sensit polici urgent need improv care older person region
D003695;D005853
T090;T058;T091;T093
36,342,741
racialethn variat acn practic algorithm treatment mainten includ skincar recommend skin color patient acn racialethn differ clinic present sequela desir treatment outcom acn report post inflammatori hyperpigment pih frequent occur patient rich pigment skin complexion frequent bothersom aspect acn popul
D000152;D017495
T047;T046
36,342,740
unit state cutan oncodermatolog manag uscom ii multidisciplinari guid algorithm prevent manag acut radiat dermat cancer patient among patient unit state estim diagnos cancer approxim requir radiat therapi rt part treatment plan radiat dermat rd common side effect rt particular patient breast head neck anal cancer wide spectrum sever degre rd develop individu consider heterogen manag rd addit contemporan treatment algorithm exist prevent treatment rd underscor need develop uniform evid direct guidelin
D009369;D003872
T047;T191
36,342,739
open label studi evalu periorbit skin rejuven efficaci cosmeceut contain methyl estradiolpropano mep women estrogen defici skin ed cosmeceut topic formul contain non hormon estrogen receptor activ methyl estradiolpropano mep develop address periorbit skin age post menopaus women estrogen defici skin ed
D000068937;D015595
T033;T073;T042
36,342,738
advanc pigment manag multiprong approach key cellular player regul human skin pigment includ melanocyt epidermi synthes melanin neighbor keratinocyt receiv distribut melanin upper layer fibroblast dermi affect over melanocyt keratinocyt addit endocrin factor blood suppli endotheli cell inflamm relat factor play role thus new strategi affect pigment need consid multipl cell line adequ cover various caus diseas process associ hyperpigment
D008543;D017495
T123;T046;T109
36,342,737
prospect singl arm split face pain manag evalu nitrous oxid system micro focus ultrasound visual although micro focus ultrasound visual mfu v great cosmet result patient hesit declin treatment due pain experienc treatment primari object assess efficaci pain manag nitrous oxid system mfu v treatment secondari object includ patient satisfact efficaci reduc facial laxiti improv aesthet appear
D015595;D014464
T033;T061;T042
36,342,736
clinic experi use monofila fiber cleans debrid technolog various skin condit gentl skin cleans exfoli use moistur adjunct medic treatment part prevent treatment mainten cutan condit acn vulgari acn psoriasi xerosi monofila fiber debrid technolog mfdt use effect safe rapid skin cleans exfoli debri slough biofilm remov current review address clinic experi use mfdt various cutan condit requir cleans exfoli combin medic treatment
D000152;D003876;D011565
T047
36,342,735
subject satisfact wrinkl reduct follow treatment fraction radiofrequ prospect studi fraction radiofrequ frf technolog reduc skin laxiti treat age relat skin disord wrinkl object studi evalu particip satisfact frf treatment facial wrinkl
D015595;D000078702
T033;T061;T042
36,342,734
assess interfer hyperdilut calcium hydroxyapatit neck rejuven ultrasonograph evalu thyroid sag neck skin common complaint use calcium hydroxyapatit inject tradit treatment approach region publish literatur limit concern possibl interfer imag exam hyperdilut product present radiopaqu featur assess deep structur applic
D012060;D015595
T061;T033;T042
36,342,733
patient prefer acn vulgari treatment barrier care survey studi associ direct indirect cost acquir acn vulgari acn treatment clinician may prohibit patient barrier care may also influenc patient prefer treatment counter otc prescript acn treatment efficaci prefer otc prescript acn medic well establish recruit adult subject unit state amazon mechan turk mturk subject survey acn acn treatment prefer barrier care total subject pass attent check includ analysi respond tri otc prescript treatment n respond report prefer prescript treatment compar otc treatment prefer p almost half respond also state experienc barrier access medic care acn treatment cost transport top factor consid common barrier everchang natur patient may benefit discuss altern non prescript acn treatment serv bridg therapi patient unabl reach medic provid j drug dermatol doijdd
D000152;D055553
T121;T047
36,342,732
evalu efficaci platelet rich plasma nm fraction laser combin alon manag androgenet alopecia androgenet alopecia aga men women common caus hair loss affect individu may experi psycholog distress social withdraw current treatment option aga minoxidil finasterid vari efficaci side effect platelet rich plasma prp photobiomodul among treatment option gain popular recent year less known effect fraction laser combat hair loss research suggest creat microscop thermal injuri zone fraction laser may caus increas hair growth wound heal process studi evalu efficaci safeti prp nm fraction erbium glass laser monotherapi combin treatment aga patient patient experienc improv aga patient treat combin therapi greater improv hair densiti overal prp nm combin alon good treatment choic aga side effect j drug dermatol doijdd
D053657;D053844
T074;T073;T031
36,342,731
skin cancer screen practic among dermatologist survey studi unit state prevent task forc usptf conclud benefit skin cancer screen inconclus systemat review found implement skin cancer screen increas detect situ thin melanoma increas incid non melanoma skin cancer detect decreas rate thick melanoma howev one studi review found reduct melanoma mortal evid notabl unclear exact benefit prevent skin cancer screen
D003880;D012878;D008545
T191;T091
36,342,730
efficaci fraction nm erbium glass laser treatment dermatofibroma treatment dermatofibroma beyond surgic excis remain inadequ elus nonsurg treatment option desir patient physician erbium glass laser known target remodel dermi yet studi treatment dermatofibroma
D018219;D053844;D053685
T061;T074;T191;T073
36,342,729
real world dermatolog evalu safeti combin laser procedur singl clinic session studi show safe multipl session singl laser treatment appropri time period allow skin heal treatment wait sever session may realist everi patient physician may combin laser treatment singl session accommod patient conveni achiev cosmet improv faster although individu laser therapi report minim side effect studi explor safeti multipl laser treatment singl session
D003880
T091
36,342,728
improv pretibi myxedema follow administr teprotumumab pretibi myxedema ptm rare complic grave diseas character non pit edema hyperpig hyperkeratot papul plaqu bilater lower leg effect treatment patient ptm lack etiolog ptm unknown howev may similar mechan thyroid associ ophthalmopathi tao activ fibroblast produc inflammatori cytokin synthes excess glycosaminoglycan gag accumul dermi subcutan tissu recent novel pathway implic igf receptor mediat process present two patient refractori ptm improv follow treatment teprotumumab igf receptor inhibitor approv use tao j drug dermatol doijdd
D009230;D006111
T047
36,342,727
concurr interstiti granulomat dermat tnf antagonist induc lupus syndrom secondari adalimumab crohn diseas tumor necrosi factor tnf antagonist revolution manag various autoimmun inflammatori condit includ rheumatoid arthriti ra inflammatori bowel diseas hidraden suppurativa psoriat arthriti plaqu psoriasi howev advers effect may necessit switch anoth biolog differ mechan action report tnf alpha antagonist induc lupus syndrom tail reveal interstiti granulomat dermat igd atyp context crohn diseas cd
D003424;D003872;D001327
T047
36,342,726
laser surgeri laser portray instagram instagram becom one primari mean public access inform societ trend entertain content one particular trend post content minim invas cosmet procedur specif laser surgeri frequent highlight social media form photo procedur video educ post offic advertis
D061108;D053685
T061;T170;T074
36,342,725
comparison pediatr dermatolog condit across telehealth person visit covid pandem understand util virtual visit pediatr dermatolog practic becom increas import telehealth era compar condit diagnos pediatr dermatolog tradit person visit virtual telehealth visit initi month phase covid pandem urban medic institut given option pediatr dermatolog patient famili like choos telehealth visit diagnosi andor manag acn hemangioma contact dermat howev like choos person visit atop dermat viral wart alopecia areata differ may attribut clinic featur pediatr skin condit treatment option factor may influenc patient prefer telehealth person care condit j drug dermatol doijdd
D000086382;D003880;D017216;D012871
T047;T058;T091;T067
36,342,724
flolan rash impress asymptomat non inflammatori erupt follow long term epoprostenol therapi epoprostenol flolan last resort intraven medic treatment sever pulmonari arteri hypertens pah cutan advers event flolan well known pulmonologist though lack dermatolog literatur report near erythroderm appear yet asymptomat erupt last year woman end stage pah treat long term intraven epoprostenol non prurit blanch erythemat papul coalesc plaqu surround hypopig halo encompass entir torso well bilater upper lower extrem addit find includ bright red palm sole associ pain tingl walk laboratori workup reveal thrombocytopenia slight elev erythrocyt sediment rate esr connect tissu diseas marker negat skin biopsi surpris larg unremark without inflammatori infiltr patient trial topic clobetasol ointment without effect strike yet asymptomat non inflammatori erupt thought due long term use epoprostenol last resort synthet prostacyclin use treat sever pah cutan find bothersom dose flolan lower lower extrem pain treat gabapentin case aim increas awar impress ldquo flolan rash rdquo persist erythemat erupt well known pulmonologist yet scarc describ dermatolog literatur signific find report strike yet asymptomat non inflammatori skin erupt last year presum due long term use epoprostenol end stage pulmonari arteri hypertens mean cutan advers event intraven epoprostenol well known pulmonologist though lack dermatolog primari care literatur extens bodi surfac involv near erythroderma associ flolan necessit awar patient dermatologist healthcar provid outsid field pulmonolog j drug dermatol doijdd
D000081029;D006976;D005076
T184;T047;T046
36,342,719
evalu cannabi use among us adult covid pandem within differ legal framework cross section studi analyz preval cannabi use us adult covid pandem within differ legal framework evalu differ associ behavior
D000086382;D002188;D064086;D006213
T121;T073;T067;T109;T131;T002;T093;T047;T167
36,342,718
associ racial wealth inequ racial dispar longev among us adult role repar payment us black individu die younger white individu less household wealth legaci slaveri ongo discrimin discriminatori public polici role wealth inequ mediat racial health inequ unclear
D005006;D044383
T098;T102
36,342,717
trend use opioid vs nonpharmacolog treatment adult pain chronic pain preval among us adult increas yet littl known trend use prescript opioid nonpharmacolog altern treat pain
D000701;D059350
T121;T184;T109;T131;T047
36,342,716
comparison evalu heart transplant durabl left ventricular assist devic subsequ receipt transplant transplant vs nontranspl center center medicar medicaid servic revis nation coverag determin remov requir obtain review medicar approv heart transplant center implant durabl left ventricular assist devic lvad bridg transplant btt intent lvad center associ center level transplant avail access heart transplant gold standard therapi advanc heart failur hf unknown
D006353;D016027;D006333
T061;T047;T074;T046
36,342,715
variat age adjust prostat cancer incid rate race ethnic chang prostat specif antigen screen recommend public us prevent task forc prostat specif antigen psa screen guidelin document associ incid stage distribut prostat cancer unclear chang temporari differ age race ethnic
D017430;D011471
T129;T191;T126;T116
36,342,714
studi select bias racial ethnic dispar estim age onset cardiometabol diseas among midlif women us racial dispar cardiometabol health consist observ cohort studi howev studi neither evalu differ age onset account systemat exclus stem weather acceler health declin minorit group due structur social econom margin
D006973;D007333;D061385
T121;T047;T046
36,342,713
nicotin addict intens e cigarett use adolesc us e cigarett becom effect deliv addict drug nicotin becom domin form tobacco use us adolesc
D000072137;D066300;D014029
T055;T073;T048
36,342,707
chang lipid profil aqueous humor diabet cataract patient identifi differenti profil lipid aqueous humor ah control diabet cataract patient
D002386;D048909;D003920
T033;T047;T190
36,342,706
iri color matter contractil analysi dynam volum render optic coher tomographi pupillometri analyz natur variabl pupillari contractil dynam volum render optic coher tomographi oct pupillometri regard iri color age sex healthi caucasian particip
D041623;D055253
T060;T040
36,342,697
probabl hospitalis death among covid patient comorbid outbreak occur mexico citi compar probabl hospit death caus covid patient comorbid three period defin studi first wave fw interwav period ip second wave sw observ mexico citi
D000086382
T047;T067
36,342,692
import featur identif perceptu sex point light walker use supervis machin learn present studi aim elucid dynam featur high predict biolog perceptu sex classif point light walker plws featur behav sex classif use supervis machin learn fifteen observ judg sex plws side view fast fourier transform appli retriev spectral compon multiphas hip shoulder movement exhaust search identifi import featur biolog perceptu sex classif individu condit expect ice support vector machin svm model use interpret behavior import featur observ judg biolog sex side view plws accuraci male plws femal plws svm model biolog sex predict demonstr third harmon hip motion play domin role achiev high predict accuraci featur interact model perceptu sex predict howev accur predict achiev use five spectral compon hip shoulder motion ice plot featur follow heterogen cours suggest featur interact machin learn model suggest biolog sex classif depend main local cue plw howev high perform model perceptu sex classif involv interact various frequenc compon hip shoulder motion suggest complex process sex percept
D000069553;D060388
T081;T066
36,342,691
individu differ look person scene individu freeli view complex scene vari fixat behavior promin reliabl dimens individu differ tendenc fixat face howev much less known observ distribut fixat across bodi part person scene individu may vari regard aim close gap expand popular annot stimulus set xu jiang wang kankanh zhao hand delin pixel mask bodi part person embed complex scene publish articl https osfioynujz resourc allow us analyz person direct fixat particip freeli view scene found larg reliabl individu differ distribut fixat across person featur individu fixat tendenc form two anticorrel cluster one eye head inner face one bodi featur torsi arm leg hand interest tendenc fixat mouth independ face cluster final result show observ tend avoid person fixat general particular face region find underscor role individu differ fixat behavior reveal under dimens line recent propos push pull relationship cortic tune face bodi may also aid comparison special popul general variat
D005403;D007206
T054;T042
36,342,684
built environ cardiovascular health review implic review present general overview state evid relationship neighborhood built environ cardiovascular health outcom among adult also summar relev literatur associ built environ activ live behavior physic activ pa sedentari behavior consid key behavior pathway
D016138;D002318
T056;T169;T047
36,342,683
screen psycholog distress risk cardiovascular diseas relat mortal systemat review meta analysi case prevent psycholog distress elev symptom depress anxieti post traumat stress disord ptsd psychosoci stress associ risk cardiovascular diseas cvd despit increas attent import factor cvd prevent state scienc requir updat synthesi enabl practic recommend moreov unknown whether psycholog distress base screener valid self report instrument effici identifi may requir mental health servic addit support associ incid cvd
D002318;D000079225;D013313
T047;T048
36,342,682
assess atherosclerot cardiovascular diseas risk primari prevent object report review applic pool cohort equat primari prevent assess cardiovascular health
D019161;D002318;D050197
T121;T047;T046;T109
36,342,681
primordi prevent atherosclerot cardiovascular diseas review literatur primordi prevent atherosclerot cardiovascular diseas ascvd involv prevent onset risk factor review explor associ earli modifi risk factor develop ascvd adulthood well evid base intervent prevent
D002318;D050197
T047;T046
36,342,670
cost manag acut respiratori infect older adult systemat review meta analysi acut respiratori infect ari account estim million death worldwid occur adult age year older aim identifi cost ari manag older adult year order develop evid base assist decis make resourc alloc inform clinic practic
D012141
T047
36,342,572
fire regim peatland angolan highland angolan highland region includ angolan miombo woodland ecoregion support miombo woodland grassland subsist agricultur land peatland deposit extens fire slash burn agricultur peat fuel extract peatland drainag among anthropogen practic threaten peatland deposit peat fire caus peatland degrad releas signific amount greenhous gase deterior air qualiti contribut toward climat chang biodivers loss studi present analysi fire regim period studi area angolan highland moder resolut imag spectroradiomet modi fire veget data use combin land useland cover lulc classif map calcul fire frequenc burn area fire regim fire pattern within studi site compar found african woodland savanna across studi site km land surfac area burn least nine time occur larg within river valley environ consid differ lulc class peatland calcul burn frequent averag fire frequenc b smallest proport area remain unburnt fire archiv c largest averag proport km burnt area per year peatland burn occur predomin drier month may septemb result studi highlight strong influenc lulc fire frequenc distribut studi area requir uniqu fire manag strategi document boreal tropic peatland across globe stress import peatland conserv protect continu unsustain manag practic may lead loss import peatland deposit
D004784;D005390
T067;T057
36,342,571
untarget metabolom human keratinocyt reveal impact exposur dichloro benzoquinon dichloro hydroxi benzoquinon emerg disinfect product dichloro benzoquinon dcbq deriv dichloro hydroxi benzoquinon dcbq oh disinfect product dbps emerg pollut environ consid particular import high potenti toxic like carcinogen
D004203;D001710
T061;T121;T127;T109
36,342,560
applic metabolom childhood leukemia diagnost metabolom new field scienc deal studi analysi metabolit form live cell biolog fluid use test method blood blood plasma serum cerebrospin fluid saliva urin popular method assess composit metabolit includ nuclear magnet reson spectroscopi mass spectrometri ms combin gas chromatographi ms liquid chromatographi ms metabolom use mani area medicin variabl biochem process neoplast cell relat healthi cell start point type research aim research current carri primarili find biomark quick diagnosi diseas assess advanc treatment effect develop metabolom may also contribut individu treatment patient adjust drug depend metabol profil thus may improv effect therapi reduc side effect help improv qualiti life patient review current potenti applic metabolom focus use biomark method childhood leukemia
D011788;D007938
T078;T191
36,342,559
humboldt darwin theori evolut numer author examin influenc thinker darwin formul key concept theori evolut amongst alexand von humboldt often stand scholar follow intent explain interconnect various part natur system seem tackl question evolut offer explicit answer articl examin humboldt thought evolut origin speci evalu contribut darwin theori evolut first analys explic fundament assumpt goal humboldt theori compar darwin move forward highlight similar method argu humboldt darwin conduct similar investig fossil record geograph distribut speci final show humboldt acknowledg essenti element darwin theori evolut evid given fossil record struggl surviv relat natur environ live organ humboldt howev conclud know evolut speci explain stanc contend theori humboldt darwin turn similar seem yet differ conclus regard evolut speci stem differ initi assumpt under respect framework
D005075;D012641
T045;T070
36,342,558
crisprca mediat knockdown vacuolar invertas gene express lower cold induc sweeten potato vinv gene edit potato use crisprca result knockdown express lower vinv enzymat activ result decreas post harvest cold storag sugar format sweeten potato crispr cas mediat knockdown vacuolar invertas vinv gene carri use two sgrnas local cultivar potato plant transform effici potato found primari transform screen pcr sanger sequenc digit pcr elisa overal edit efficaci determin per tide analysi amplicon sequenc data show maximum indel frequenc potato plant result gene knockout frame shift plant b maximum indel frequenc found result knockout frameshift analyz geneious qrt pcr data reveal mrna express vinv gene reduc fold edit potato plant compar non edit control potato plant follow cold storag chip analysi potato prove b best line reduc sugar analysi titrat method determin fivefold reduct percentag reduc sugar tuber b transgen line compar control physiolog genom edit potato behav like convent counterpart first success report knockdown potato vinv gene pakistan address cold induc sweeten result minimum accumul reduc sugar genom edit tuber
D043324;D011198
T121;T116;T168;T126;T002
36,342,554
qsar studi h pyrazol deriv egfr inhibitor epiderm growth factor receptor egfr highlight target anticanc treatment sever egfr inhibitor approv cancer treatment compar qsar new methodolog consid ensembl differ induc fit model base h pyrazol deriv egfr inhibitor qsar studi method quasi atomist receptor surfac model use present qsar model show contribut hydrogen bond acceptor hydrophob salt bridg field activ qsar model statist valid also extern valid appli compound test set includ model generat process scrambl test perform verifi robust apart explor bind h pyrazol deriv egfr qsar model help design new egfr inhibitor five dimension quantit structur activ relationship qsar h pyrazol deriv egfr inhibitor quasi atomist receptor surfac model approach describ
D021281;D047428
T081;T121;T116
36,342,553
assess high spatial resolut satellit imageri monitor riparian veget riverin manag smallhold riverin habitat essenti ecoton bridg aquat terrestri ecosystem provid multipl ecosystem servic studi analys potenti use high resolut satellit imageri provid worldview satellit order assess viabil monitor riparian ecosystem perform calcul riparian strip qualiti index rsqi calibr riparian qualiti index qbr methodolog implement umia river characteris elev anthropogen pressur locat northwest spain result obtain method verac kappa coeffici averag qualiti valu obtain rsqi index averag valu qbr differ could attribut fact former differ autochthon non autochthon veget area accur map correspond stretch veget optim cover good connect adjac forest ecosystem presenc invas plant worst score site next characterist low connect low forest cover higher presenc invas plant degrad veget could explain presenc agricultur defici land use ration caus type ownership studi area applic index satellit imag facilit environment govern multipl ecosystem special riparian ecosystem obtain quick object methodolog easili replic basin
D063809;D017753
T068;T070;T073;T082
36,342,549
influenc climat chang freshwat avail sokoto rima river basin northwestern nigeria research entail acquisit long term meteorolog data rainfal temperatur runoff use comput valu mean annual month season hydro climat variabl establish trend behavior substanti pattern runoff way due chang climat meteorolog data subject non parametr test mann kendal mk sen slope estim kendal tau partial correl mk trend test runoff rainfal temperatur annual season basi reveal signific trend annual scale nevertheless rainfal data exhibit observ trend season scale annual season scale temperatur valu show increas trend entir period consid runoff also exhibit remark increas trend sen estim valu rang result kendal tau correl show runoff posit correl rainfal tau high confid level partial correl analysi runoff climat variabl annual season timescal result show runoff signific r xyz affect rainfal temperatur therefor recommend futur research util robust input output model determin amount water stress basin sustain manag approach artifici surfac water reservoir construct complement avail water sokoto rima river allevi water stress experienc popul
D045483;D057231
T070
36,342,548
baselin assess hydrolog network land use riparian buffer pampean stream uruguay integr assess stream network terrestri land use contribut critic foundat understand mitig potenti impact stream ecolog riparian zone delin manag key compon regul water qualiti particular agricultur watersh present nation assess riparian zone land use accord stream order entir hydrolog network uruguayan landscap southeastern south america classifi km stream river uruguay seven strahler order class delin riparian buffer depend stream order cover total terrestri land area uruguay natur veget cover riparian zone averag among basin wherebi natur grassland domin first second order stream buffer respect highlight import grassland headwat region countri riparian forest form corridor along larger stream repres mere buffer first order stream reach buffer th order stream among six major basin uruguay found differ relat import riparian forest crop cover headwat stream riparian zone well differ relat crop cover within riparian zone result show stream subtrop grassland landscap origin open grassland environ major implic thermal regim carbon input stream biodivers riparian buffer manag consid geograph differ among differ basin ecoregion within uruguay
D004784;D045483
T070;T057
36,342,547
fluoro function ionic coval organ framework f icof high select enrich sensit determin perfluorin sulfon maldi ms easili prepar fluoro function ionic coval organ framework f icof implement maldi tof ms enabl high select enrich sensit determin perfluorin sulfon pfs contamin rapid conveni manner good thermal stabil excel optic absorpt properti f icof make brilliant matrix background nois moreov benefit larg surfac area appropri pore size good water dispers abund fluorin atom cation characterist f icof exhibit superior adsorpt capac enrich select toward pfss good signal respons pfss obtain presenc various interf compound bsa ha even fold excess glutam acid similar structur sodium alkyl sulfon highlight specif select f icof calibr curv potassium perflurobutan sulfon pfbsk tap water whole blood establish good linear correl rang pg ml limit detect quantif pfbsk low pg ml pg ml respect compar better exist method determin pfss
D000073396
T109
36,342,544
burrow builder ecosystem engin pit build antlion neuroptera myrmeleontida burrow builder often classifi ecosystem engin dig activ regul avail resourc organ antlion larva prefer construct trap bare sandi loos soil could benefit burrow activ investig role burrow builder ecosystem engin antlion myrmeleontida tropic semidecidu forest mexico number trap antlion larva record sampl quadrat cm entranc burrow unidentifi builder pair burrow quadrat addit percentag bare soil estim quadrat sampl quadrat entranc burrow total trap record least one trap burrow quadrat two trap three total percentag bare soil abund trap signific greater quadrat entranc burrow compar quadrat without burrow abund trap entranc burrow posit affect percentag bare soil trap burrow quadrat suggest addit limit bare soil ground compact probabl limit establish antlion larva otherwis dig burrow builder creat small patch bare sandi soil use insect conclud ecosystem engin effect burrow builder import structur element antlion popul tropic semidecidu forest studi
D017753;D065928
T070;T082
36,342,543
model studi role vitamin b thiamin b nicotinamid b pyridoxamin caffein potenti lead drug design covid respons covid pandem lack effect safe antivir adopt new approach food supplement vital antivir characterist low toxic fast excret target structur chemic properti food supplement compar promis antivir sar cov goal exploit food supplement mimic topic antivir function circumv sever side effect limit necessari dosag need exhibit desir antivir activ line compar structur analysi chemic mention investig potenti mechan action select caffein compound vitamin b famili appli molecular model techniqu evalu interact rdb domain spike protein sar cov scspike correspond bind site human ace hssace result point vitamin b b neutral form potenti binder hssace rdb bind pocket might abl impair sar cov mechan cell invas qualifi potenti lead experiment investig covid
D000086382
T047;T067
36,342,532
biomonitor nile delta lake use benthic foraminifera lake edku one northern nile delta lake shallow brackish coastal lake subject domest agricultur effluent via two main drain el khairi barsik addit discharg water hundr fish farm studi measur respons benthic foraminifer assemblag environment stressor lake edku grain size organ carbon seven potenti toxic element cu pb zn cd cr ni determin nine short core cm depth lake character vertic increas mud organ matter concentr metal particular eastern basin vicin drain discharg trend coincid general decreas speci divers increas deform specimen foraminifer assemblag domin ammonia tepida cushman pollut toler euryhalin speci studi demonstr benthic foraminifer assemblag provid reliabl pollut proxi brackish environ nile delta use period monitor coastal lake
D056908;D014874;D019216
T131;T196;T204
36,342,531
ism approach overcom particip barrier wast sourc separ case studi urmia univers campus procedur develop identifi facilit implement wast sourc separ strategi applic higher educ center prerequisit expans recycl program target materi proper separ select base quantitativequalit analysi wast produc nazlou campus urmia univers iran case studi barrier implement program identifi use interpret structur model ism methodolog final regard main obstacl could broken insid campus complex analysi factor affect student particip done averag ton wast daili produc campus could recycl base siev analys categori non ferrous metal glass composit packag wider size distribut ie mm might lead improp oper mechan separ select target materi weak educ program persuad student consid main obstacl signific relationship observ three train option name instal announc organ wast manag class train hold exhibit recycl product student particip program emphasi last one women estim like men particip program vs also signific relationship knowledg student particip word strengthen public awar essenti increas particip level
D004784;D018505
T068;T057
36,342,496
shop look like actual practic health care lack transpar cost health care servic patient clinic encount contribut increas cost high pocket expens feder polici respond need transpar spur discuss ethic clinician role transpar patient point servic articl investig encourag state privat market feder polici effort address health care cost patient articl also appli ethic framework principl case consid shoppabl servic model would demand clinician practic
D005102;D017048
T081
36,342,494
bank card might well tarot card comic compar lack price transpar health care bill psychic card read
D003695
T058;T093
36,342,492
us policymak learn intern drug price transpar strategi articl analyz differ prescript drug price transpar practic among organis econom co oper develop member nation unit kingdom germani canada specif articl compar countri polici list net price disclosur intern refer price use evalu merit drawback differ price transpar approach final articl summar policymak unit state learn comparison
D016527;D055553
T081;T121
36,342,491
price transpar price privat insur negoti health care organ clinician histor confidenti sinc earli privat insur patient face increas pocket cost demand inform variabl negoti price slowli becom avail articl argu fragment us health care deliveri stream shortcom formal qualiti measur mean valu make price transpar use tool policymak regul rather patient
D007343;D005102
T081;T092
36,342,490
necess limit price transpar american health care price transpar ethic polici imper american health care transpar price would allow patient famili make better decis would allow clinician deliv care greater simplic integr articl also consid transpar real world patient care limit extent price transpar reliabl pathway servic deliveri effici market disciplin
D003695;D006268
T058;T073;T093
36,342,489
inform consent mean acknowledg avoid financi toxic iatrogen harm negat health consequ stem financi burden care patient love one document financi toxic literatur consequ includ inform consent discuss patient clinician interact howev code medic ethic yet requir obtain consent financi cost even surpris act effect januari requir clinician facilit inform financi consent prior network elect servic mean avoid arbitr articl discuss requir broad appli inform consent intervent
D000086522;D007258
T033;T089;T041
36,342,488
patient nt use avail health servic price inform transpar still import us health system replet health servic price idiosyncrasi opac unrel qualiti onlin tool intend make health care purchas resembl consumer make price transpar littl effect improv health care market function chang patient behavior although price transpar still infanc hold promis use patient consum larg purchas eg employ health servic policymak even price inform routin use patient transpar inform still ethic import market patient pay increas high pocket cost
D006296;D005102
T081;T058
36,342,487
clinician health servic improp bill name center medicar medicaid servic mandat physician respons make sure reimburs servic physician provid patient accur appropri yet shift physician practic ownership various employ model amplifi dilemma physician work employe us health care compani might know servic bill name much less abl review contest cost servic bill although practic violat legal standard mani employ physician account without transpar agenc commentari case consid set problem contemporari bill reimburs structur practic
D006278;D006296
T089;T058;T064
36,342,486
cost inform goal care decis facilit life end intervent near patient death unit state often expens burdensom inconsist patient goal prefer patient love one make inform care decis physician must share adequ inform prognos prospect benefit harm specif intervent cost commentari case discuss strategi share inform suggest proper design advanc care plan incent help improv communic decis share
D032722;D010820;D013727
T058;T097
36,342,485
might patient physician use transpar health care price guid decis improv health care afford mani american face high cost share demand health insur hope price health servic becom transpar even increas avail price inform alway translat optim equit health financi outcom patient commentari case argu transpar price ethic imper identifi step health sector stakehold take help patient clinician use price inform inform health decis make
D017150;D010820
T064;T098;T097
36,342,472
dishevel phase separ promot wnt signalosom assembl destruct complex disassembl amplitud wnt catenin signal precis control assembl cell surfac local wnt receptor signalosom cytosol catenin destruct complex two distinct complex coordin control remain larg unknown demonstr signalosom scaffold protein dishevel dvl undergo liquid liquid phase separ llps dvl llps mediat intrins disord region facilit compon signalosom receptor fzd assembl signalosom initi rapid recruit dvl membran follow slow dynam recruit axin axin llps mediat assembl catenin destruct complex dvl attenu llps axin compar destruct complex axin partit signalosom lower concentr exhibit higher mobil togeth result reveal dvl llps crucial control assembl wnt receptor signalosom disrupt phase separ catenin destruct complex
D060465;D060449
T026;T044
36,342,465
contrast effect ksr obes gene trabecular bone volum bone marrow adipos patholog obes complic associ increas propens bone fractur human certain genet polymorph kinas suppressor ras ksr locus develop sever earli onset obes type diabet condit phenocopi mice ksr delet whether affect bone health remain unknown studi bone global ksr null mice found ksr negat regul femor vertebr bone mass two genet background paralog gene ksr dispens bone homeostasi mechanist ksr regul bone format influenc adipocyt differenti expens osteoblast bone marrow compar ksr known role regul feed function hypothalamus pair feed osteoblast specif condit delet ksr reveal ksr regul bone format autonom despit gain appendicular bone mass observ absenc ksr bone strength well fractur heal respons remain compromis mice studi highlight interrelationship adipos bone health provid mechanist insight ksr adipos diabet gene regul bone metabol
D050154;D003924
T047;T032
36,342,462
tumor hyaluronan novel biomark non small cell lung cancer retrospect studi hyaluronan ha accumul associ tumorigenesi aggress tumor behavior
D002289;D008175;D000230;D002294
T191
36,342,456
mk novel cdk inhibitor potent antitumor activ aml downregul stat pathway acut myeloid leukemia aml lethal form aml due diseas relaps cyclin depend kinas cdk serinethreonin kinas belong famili cyclin depend kinas emerg target treatment aml mk potent select oral avail cdk inhibitor develop target aml sought examin anticanc effect mk aml cdcd leukemia stem cell found mk induc differenti matur treatment mk inhibit prolifer aml cell line studi inhibitori effect suggest mk downregul phosphoryl stat stat also lower mrna express mcl ccl aml cell line efficaci mk shown molm xenograft model inhibitori effect phosphoryl stat stat treatment mk observ vivo pharmacolog dynam studi mk molm xenograft model show dose depend inhibit stat pathway vitro vivo studi suggest mk could effect downregul stat pathway vitro adm pharmacolog kinet toxic mk profil evalu drug properti mk result show mk novel cdk inhibitor desir efficaci safeti profil great potenti promis drug candid aml regul stat pathway
D050799;D015470
T123;T191;T116
36,342,455
human type ifn defici impair b cell respons sar cov mrna vaccin inborn acquir deficit type interferon ifn immun predispos life threaten covid pneumonia longitudin profil b cell respons mrna vaccin sar cov naiv patient inherit tlr irf ifnar defici well young patient autoantibodi neutral type ifn due autoimmun polyendocrin syndrom type ap older individu age associ autoantibodi type ifn receptor bind domain spike protein rbd specif memori b cell respons patient quantit qualit similar healthi donor sustain germin center respons led accumul somat hypermut immunoglobulin heavi chain gene amplitud durat viral neutral rbd specif igg serolog respons also larg unaffect tlr irf ifnar defici mo vaccin patient result suggest induct type ifn requir effici generat humor respons sar cov mrna vaccin
D000086402;D000086382
T005;T067;T047
36,342,395
clinic practic pattern isthmic spondylolysi young athlet survey pediatr research sport medicin member isthmic spondylolysi common caus back pain young athlet condit present numer medic provid employ varieti differ practic diagnosi manag purpos studi twofold review literatur diagnosi manag young athlet isthmic spondylolysi survey pediatr research sport medicin prism member prism annual meet practic pattern diagnosi manag young athlet isthmic spondylolysi respons rate per respond obtain obliqu radiograph use magnet reson imag advanc imag modal treat brace recommend rest prior physic therapi pt prescrib return sport activ restrict although similar diagnosi isthmic spondylolysi young athlet survey confirm variabl manag especi brace time pt return sport activ restrict
D013169;D013178;D013177
T047;T091;T056
36,342,394
head pain competit aquat athlet approach differenti diagnosi manag aquat athlet face common headach etiolog similar general popul land base athlet also experi uniqu patholog postur aquat pressur equip even marin anim pose uniqu caus head pain aquat athlet common head pain patholog seen aquat athlet includ tension type headach migrain cluster headach compress headach includ supraorbit neuralgia creat thorough focus differenti diagnosi head pain aquat athlet difficult overwhelm task review common common etiolog head pain aquat athlet suggest simpl framework assess treatment diagnos treat head pain specif popul
D006261;D009437
T184;T047
36,342,391
unusu case arm pain young soccer player herp zoster pediatr athlet herp zoster hz shingl caus varicella zoster virus vzv hz develop reactiv latent vzv character pain vesicular rash typic manifest dermatom distribut arm trunk face hz occur individu primari vzv diseas chickenpox child receiv live attenu vzv vaccin hz common elder immunocompromis age singl greatest risk factor incid hz children person year unvaccin person year vaccin discuss case year old soccer player hz present right arm pain putat traumat event diagnosi made two emerg depart visit condit identifi hz consid clinician differenti even immunocompet vaccin children
D006562;D010146
T184;T047
36,342,311
anim model osteoarthr part preclin small anim model challeng opportun drug develop osteoarthr oa common form arthriti major sourc pain disabl adult popul signific unmet medic need develop effect pharmacolog therapi treatment oa addit spontan occur anim model oa mani experiment anim model develop provid insight mechan pathogenesi progress mani anim model also use drug develop pipelin provid overview common use emerg preclin small anim model oa highlight strength limit small anim model context translat drug develop limit inform publish literatur regard technic reliabl small anim model abil accur predict clinic drug develop outcom cost complex avail model howev import consider pharmaceut compani biotechnolog startup contract research organ wish incorpor preclin model target valid discoveri develop pipelin consider relev industri includ timelin method induct key issu reproduc appropri outcom measur need object assess outcom experiment therapeut preclin small anim model indispens tool shine light pathogenesi oa molecular endotyp context drug develop paper focus small anim model use preclin oa research author current protocol publish wiley period llc
D010003;D001169
T047;T050
36,342,310
pharmacolog manag parkinson diseas motor symptom updat recommend expert parkinson diseas pd neurodegen multisystem disord affect approxim popul year old mean age onset year old preval diseas constant grow
D010300;D020820
T184;T047
36,342,306
implement high dimension reduct analysi histocytometr data previous protocol articl demonstr construct histocytometri pipelin capabl segment high aggreg cell popul retain origin intens data rang input microscopi imag protocol present use output aforement articl demonstr phenotyp data use high dimension reduct analysi techniqu optim distribut stochast neighbor embed opt sne compar tradit manual gate addit present protocol illustr advantag inclus cell junctionmembran marker accur segment high aggreg cell popul ilastik wiley period llc basic protocol phenotyp lymph node popul use manual gate basic protocol phenotyp lymph node popul use sne dimension reduct support protocol ilastik segment use pan marker
D000465
T170
36,342,272
solut phase chemic synthesi modifi rna dinucleotid articl describ simpl reliabl effici improv solut phase method gram scale chemic synthesi rna dinucleotid pa pa pa pg pa pu util phosphoramidit chemistri overal synthet strategi involv three step first step involv coupl reaction mmt protect nucleosid phosphoramidit protect nucleosid contain free oh group presenc tetrazol follow oxid phosphit triester use tert butyl hydroperoxid give correspond protect n pn next mmt cleav trichloroacet acid dichloromethan condit final hydroxyl group phosphoryl use activ bis cyanoethyl n n diisopropyl phosphoramidit use tetrazol follow oxid trival pentaval phosphorus use tert butyl hydroperoxid subsequ deprotect use ammonium hydroxid afford correspond rna dinucleotid pn pn good yield high puriti wiley period llc
D012313;D009705
T121;T114
36,342,267
nucisporomicrobium flavum gen nov sp nov new member famili micromonosporacea isol salin alkali soil gram stain posit aerob actinobacterium design strain neau isol salin alkali soil collect daqe citi heilongjiang provinc pr china strain neau found produc abund substrat mycelia aerial hypha substrat mycelia form irregular pseudosporangia consist nuciform spore surfac spore smooth rrna gene sequenc analysi show strain neau cluster pseudosporangium ferrugineum couchioplan caeruleus subsp azureus dsm c caeruleus subsp caeruleus dsm within famili micromonosporacea close relat p ferrugineum strain contain meso diaminopimel acid cell wall diamino acid mk h menaquinon whole cell sugar profil consist glucos galactos xylos arabinos polar lipid diphosphatidylglycerol phosphatidylethanolamin unidentifi phospholipid phosphatidylinositol unidentifi lipid major fatti acid summar c c c iso c iso c low digit dna dna hybrid averag nucleotid ident valu could differenti strain neau relat type strain phenotyp genet chemotaxonom data also indic strain neau occupi branch separ known genera famili micromonosporacea addit genom analysi confirm strain neau potenti produc chitinas therefor strain neau repres novel speci new genus speci famili micromonosporacea name nucisporomicrobium flavum gen nov sp nov propos type strain nucisporomicrobium flavum neau cctcc aa jcm
D058441;D008848
T070;T007
36,342,252
prospect studi nm picosecond laser treatment pigment lesion face dorsal hand pigment lesion chronic uv photoag extrem common face hand
D053844;D028022;D010859;D015595
T061;T073;T042;T033;T019;T047;T074
36,342,251
efficaci microneedl glycol acid peel versus microneedl trichloroacet acid peel treatment atroph acn scar random control trial combin microneedl chemic peel simpl cost effect treatment acn scar
D000152;D003240
T047
36,342,250
high patient satisfact month onabotulinumtoxina treatment upper facial line onabotulinumtoxina safeti efficaci well establish upper facial line ufl includ forehead line fhl glabellar line gl crow feet line cfl
D019274;D003357;D017060;D015595
T061;T129;T121;T116;T109;T080;T131;T042;T033
36,342,249
assess adult patient facial deform inject treatment current classif system methodolog meet import patient need mani individu affect facial deform inject aesthet treatment often use improv appear andor dynam function howev best meet need patient broad applic methodolog requir classifi deform assess sever develop treatment strategi
D057189
T170
36,342,247
patient educ scar follow moh micrograph surgeri patient prefer inform deliveri multipl modal patient educ rang written audiovisu format howev littl known regard modal optim
D012878;D005153
T191
36,342,245
bupivacain reduc pain narcot use moh micrograph surgeri limit data exist bupivacain inject moh micrograph surgeri mms
D002045;D009293
T121;T048;T109
36,342,229
target ppa cancer therapeut modul protein phosphatas play essenti role negat regul kinas signal cascad involv cytoskelet organ protein phosphatas ppa high conserv predomin serinethreonin phosphatas nervous system constitut neuron phosphatas ppa involv divers regulatori function includ cell cycl progress apoptosi dna repair although ppa histor identifi tumor suppressor inhibit ppa paradox demonstr potenti therapeut target various cancer lb water solubl small molecul competit inhibitor ppa shown particular promis chemo radio sensit agent preclin success led profus clinic trial lb adjuv therapi includ phase trial extens stage small cell lung cancer phase iii trial myelodysplast syndrom phase ii trial recurr glioblastoma complet phase trial assess safeti lb docetaxel various relaps solid tumor herein review develop lb role ppa cancer biolog recent advanc target ppa inhibit immunotherapi
D054648;D009369
T191;T126;T116
36,342,228
femal male cblj offspr expos matern obesogen diet develop alter hypothalam energi metabol adulthood matern obes exceed common strong link offspr obes metabol diseas hypothalam function critic obes develop hypothalam mechan caus obes follow exposur matern obes elucid therefor studi cohort cblj dam treat control high fat high sugar diet adult offspr explor potenti hypothalam mechan explain link matern offspr obes dam treat obesogen diet heavier mild insulin resist reflect common metabol diseas pregnanc adult offspr expos matern obesogen diet chang bodi weight signific increas fat mass decreas glucos toler decreas insulin sensit elev plasma leptin elev plasma thyroid stimul hormon addit offspr expos matern obes decreas energi intak activ without chang basal metabol rate hypothalam neurochem profil transcriptom demonstr decreas neuron activ inhibit oxid phosphoryl collect result indic matern obes without diabet associ adipos decreas hypothalam energi product offspr hypothes alter hypothalam function signific contribut obes develop futur studi focus neuroprotect strategi aim improv hypothalam function may decreas obes develop new noteworthi offspr expos matern diet induc obes demonstr phenotyp consist energi excess contrari previous studi observ energi phenotyp associ hyperphagia decreas basal metabol rate rather decreas hypothalam neuron activ energi product support neurochem chang hypothalamus well inhibit hypothalam oxid phosphoryl pathway result highlight potenti neuroprotect intervent prevent obes fetal origin
D000079262;D007333;D008659;D011297
T033;T047;T046;T037
36,342,182
determin phase durat use ethynyl deoxyuridin incorpor saccharomyc cerevisia eukaryot dna replic high regul process ensur genet blueprint cell correct duplic prior chromosom segreg dna synthesi defect underli chromosom rearrang monitor dna replic becom essenti understand basi genom instabl saccharomyc cerevisia classic model studi cell cycl regul key dna replic paramet fraction cell phase phase durat still difficult determin protocol use short non toxic puls ethynyl deoxyuridin edu thymidin analog engin tk hent yeast cell follow detect click reaction allow visual quantif dna replic high spatial tempor resolut singl cell popul level microscopi flow cytometri method may identifi previous overlook defect phase cell cycl progress yeast mutant therebi allow character new player essenti ensur genom stabil
D012441;D003857
T123;T004;T114
36,342,180
synovi fluid analysi identifi osteoarthr synovi fluid sf analysi import diagnos osteoarthr oa macroscop microscop featur includ total differenti white blood cell wbc count help defin non inflammatori natur sf hallmark oa patient oa wbc sf sampl usual exceed cell per microlit percentag inflammatori cell neutrophil low absent calcium crystal frequent sf collect oa patient although role pathogenesi oa remain unclear associ mild inflammatori process sever diseas progress recent calcium crystal describ earli late stage oa indic may play vital role diagnos differ clinic subset oa pharmacolog treatment overal goal sf analysi oa two fold ascertain non inflammatori degre sf highlight presenc calcium crystal
D013582;D010003
T047;T031
36,342,179
isol next generat gene therapi vector engin barcod screen adeno associ virus aav capsid variant gene deliveri vector deriv adeno associ virus aav one promis tool treatment genet diseas evidenc encourag clinic data approv sever aav gene therapi two major reason success aav vector prior isol various natur occur viral serotyp distinct properti ii subsequ establish power technolog molecular engin repurpos high throughput boost potenti techniqu recent implement strategi barcod select aav capsid dna rna level permit comprehens parallel vivo stratif major organ cell type singl anim present basic pipelin encompass set complementari avenu use aav peptid display repres divers arsenal avail capsid engin technolog accord first describ pivot step generat aav peptid display librari vivo select candid desir properti follow demonstr barcod interest capsid variant secondari vivo screen next exemplifi methodolog creation librari next generat sequenc ngs includ barcod amplif adaptor ligat conclud overview critic step ngs data analysi protocol report versatil adapt research easili har enrich optim aav capsid variant favorit diseas model gene therapi applic
D000229;D002213
T005;T017
36,342,175
fluoresc activ nuclei negat sort neuron combin singl nuclei rna sequenc studi hippocamp neurogen nich adult hippocamp neurogenesi ahn consist lifelong mainten prolif quiescent neural stem cell nscs within sub granular zone sgz dentat gyrus dg differenti newli born neuron granul cell granul cell layer well valid across numer studi use genet modifi anim particular rodent valuabl tool investig signal pathway regul ahn studi role cell type compos hippocamp neurogen nich address latter method combin singl nuclei isol next generat sequenc signific impact field ahn identifi gene signatur cell popul refin techniqu howev need phenotyp profil rarer cell popul within dg present method util fluoresc activ nuclei sort fan exclud neuron popul singl nuclei suspens isol fresh dissect dg select unstain nuclei neun antigen order perform singl nuclei rna sequenc snrna seq method potenti steppingston investig intercellular regul ahn uncov novel cellular marker mechan across speci
D055495;D058953
T040;T025
36,342,172
real time dynam collect hippocamp extracellular fluid conscious rat use microdialysi system varieti central nervous system cns diseas associ chang composit hippocamp extracellular fluid hecf howev difficulti obtain hecf real time conscious rat long restrict evalu cns diseas progress effect ethnomedicin therapi encourag brain microdialysi techniqu use continu sampl advantag dynam observ quantit analysi small sampl size allow monitor chang extracellular fluid content compound tradit herb metabolit brain live anim aim studi thus accur implant cerebrospin fluid microdialysi probe hippocamp region spragu dawley sd rat three dimension brain stereotax apparatus cut molecular weight greater kda high qualiti hecf obtain conscious rat use microdialysi sampl control system adjust sampl rate nlmin mlmin conclus protocol provid effici rapid dynam method obtain hecf awak rat help microdialysi technolog provid us unlimit possibl explor pathogenesi cns relat diseas evalu drug efficaci
D045604;D001923
T040;T031
36,342,167
silico identif character circrna host pathogen interact circular rnas circrna class non code rnas form via back splice circrna predomin studi role regul various biolog process notabl emerg evid demonstr host circrna differenti express de upon infect pathogen eg influenza coronavirus suggest role circrna regul host innat immun respons howev investig role circrna pathogen infect limit knowledg skill requir carri necessari bioinformat analysi identifi de circrna rna sequenc rna seq data bioinformat predict identif circrna crucial verif function studi use cost time consum wet lab techniqu solv issu step step protocol silico predict character circrna use rna seq data provid manuscript protocol divid four step predict quantif de circrna via ciriqu pipelin annot via circbas character de circrna circrna mirna interact predict circr pipelin function enrich analysi circrna parent gene use gene ontolog go kyoto encyclopedia gene genom kegg pipelin use drive futur vitro vivo research unravel role circrna host pathogen interact
D000079962;D035683
T123;T114