PMID
int64 35.7M
36.4M
| Title/Abstract
stringlengths 22
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|---|---|---|---|
36,343,274
|
tempor fluctuat cardiovascular paramet intravitr inject despit effect intravitr inject ivi anti vascular endotheli growth factor treat retin diseas remain pauciti evid potenti system risk associ procedur studi aim investig cardiovascular paramet risk hypertens urgenc ivi
|
D006973;D012164;D002386
|
T033;T047;T190
|
36,343,273
|
inferior base nasolabi flap reconstruct full thick medium size lower lip commissur defect follow ablat cancer surgeri inform regard design usag inferior base nasolabi flap lower lip commissur defect reconstruct follow ablat cancer surgeri remain limit studi aim provid design experi reconstruct purpos
|
D009062;D019651
|
T061;T191
|
36,343,272
|
risk factor mortal system lupus erythematosus patient analysi adult pediatr cohort taiwan overal surviv system lupus erythematosus sle patient signific increas recent decad howev relat risk mortal still high long term surviv outcom pediatr sle remain unclear studi aim explor long term surviv rate predictor patient system lupus erythematosus sle
|
D008180;D018805;D051436;D006973
|
T047;T046
|
36,343,271
|
requir nucleic acid test covid public health emerg current regulatori taiwan singapor unit state mid covid case reach close million overal infect rate hard confirm even effect vaccin break infect new variant occur safe reliabl test still play critic role isol infect individu control outbreak covid pandem respons urgent need diagnost test covid rapid evolv improv day health author mani countri issu requir detect sar cov diagnosi test pandem time access test ensur safeti effect studi compar requir eua taiwan singapor unit state perform evalu nucleic acid extract inclus limit detect lod cross reactiv interfer cutoff stabil requir similar three countri use natur clinic specimen need clinic evalu taiwan unit state howev carri cross contamin studi exempt taiwan unit state requir singapor review outlin requir insight guid test develop develop ivd consid rapid evolv virus sever pandem covid time accur diagnost test imper manag diseas note perform requir sar cov nucleic acid test similar taiwan singapor unit state differ main two point recommend microorgan cross reactiv studi specimen requir clinic evalu studi provid overview current requir sar cov nucleic acid test taiwan singapor unit state
|
D000086382;D009696
|
T123;T047;T067;T114
|
36,343,269
|
bayesian switch linear dynam system estim seizur chronotyp epilepsi disord character paroxysm transit multist state dynam system use model paroxysm natur seizur time intracrani electroencephalographi eeg record recent discov electrograph measur epileptogen interict epileptiform activ exhibit cycl pattern rang ultradian multidien rhythmic seizur phase lock specif phase latent cycl howev mani mechanist question seizur cycl remain unansw provid principl approach recast model seizur chronotyp within statist dynam system framework develop bayesian switch linear dynam system slds variabl select estim latent seizur cycl propos markov chain mont carlo algorithm employ particl gibb ancestr sampl estim latent cycl epilepsi appli unsupervis learn spectral featur latent cycl uncov cluster cycl tendenc analyz largest databas patient report seizur world comprehens character multidien cycl pattern among peopl epilepsi span infanc older adulthood work advanc knowledg cycl epilepsi investig multidien seizur cycl vari peopl epilepsi demonstr applic slds frame seizur cycl within nonlinear dynam system framework also lay groundwork futur studi pursu data driven hypothesi generat regard mechanist driver seizur cycl
|
D004569;D004827
|
T060;T047;T033;T034
|
36,343,268
|
wealth redistribut promot happi much happi could gain world wealth distribut equal despit decad research investig relationship money happi experiment work quantifi effect peopl across global econom spectrum estim total gain happi generat pair high net worth donor redistribut us million wealth cash transfer peopl preregist analys offer causal evid cash transfer substanti increas happi among econom divers individu around world recipi lower incom countri exhibit happi gain three time larger higher incom countri still cash provid detect benefit peopl household incom
|
D006240;D007182
|
T078;T081;T041
|
36,343,267
|
kifa defici caus earli onset neurodegener kifa atyp kinesin capac depolymer microtubul patient carri mutat kifa suffer progress microcephali mental disabl role protein well document neuron migrat relationship dysfunct pathobiolog brain disord unclear report kifa dispens embryogen neurogenesi critic postnat stage matur connect mainten neuron use condit approach inactiv kifa cortic progenitor nascent postmitot neuron matur neuron mice show lack kifa alter microtubul dynam disrupt sever microtubul depend process includ neuron polar neuritogenesi synaptogenesi axon transport kifa defici neuron exhibit aberr electrophysiolog characterist neuron connect function lead loss role kifa limit develop fulli matur neuron requir kifa surviv result emphas addit function kifa help explain mutat lead brain disord
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D012097;D001927
|
T123;T047;T116
|
36,343,266
|
cryo em structur cancer specif helic kinas domain mutat pik phosphoinositid kinas pik famili lipid kinas perform multipl import cellular function protein investig belong class ia pik dimer consist catalyt subunit p regulatori subunit p refer pik catalyt subunit p frequent mutat cancer mutat induc gain function constitut drive forc cancer develop mutat lead singl amino acid substitut one three site p two helic domain protein ek ek one c terminus kinas domain hr report cryo electron microscopi structur mutant complex p specif inhibitor byl hr mutant rotat sidechain new posit weaken k activ loop interact therebi reduc inhibitori effect p p ek ek complet abolish tight interact helic domain p n termin sh domain p lead disrupt p bind dramat increas flexibl adaptor bind domain abd p yet dimer pik preserv abd p interact local global structur featur induc mutat provid molecular insight activ pik deepen understand oncogen mechan import signal molecul may facilit develop mutant specif inhibitor
|
D019869;D009369
|
T191;T126;T116
|
36,343,265
|
fertil women seek status via prestig domin biolog predictor human domin hot contest far reach implic psycholog sex differ placement men women social hierarchi investig focus domin men testosteron diminish attent paid domin women biolog mechan investig biolog influenc rout status attain popular among women via prestig addit domin also neglect examin whether status seek via prestig via domin covari fertil probabl citizen scienc project span countri world region across observ particip track menstrual cycl characterist motiv prestig domin domin contest outcom three domain self esteem self esteem predict status within group help individu navig social hierarchi bayesian mix model control menstruat indic motiv obtain status via prestig domin peak concept like domin contest loss two self esteem domain fertil appear reorient femal psycholog toward prestig base strategi success enhanc women desir social capit influenc admir fear coercion intimid insight fundament advanc understand biolog correl status seek among women suggest fertil motiv mate competit gain rank posit regard social hierarchi
|
D012930;D006608
|
T054;T080
|
36,343,264
|
map prohormon process proteas human enteroendocrin cell use genet engin organoid model enteroendocrin cell eec secret hormon respons ingest nutrient control physiolog process appetit insulin releas eec hormon synthes larg proprotein undergo proteolyt process generat bioactiv peptid mutat eec enrich proteas associ endocrinopathi due relat rariti eec pauciti vitro model intestin prohormon process remain challeng assess human gut organoid eec effici induc subject crispr cas mediat modif eec express endopeptidas exopeptidas gene employ mass spectrometri base analys monitor peptid process identifi glucagon product intestin eec stimul upon bone morphogen protein bmp signal map substrat product major eec endo exopeptidas studi provid comprehens descript peptid hormon produc human eec defin role specif proteas generat
|
D009940;D010447
|
T121;T126;T116;T024
|
36,343,262
|
sequestr dual function dna bind protein vibrio cholera crp although mechan cyclic amp receptor protein crp regul global gene transcript intens studi decad new discoveri remain made report rapid growth crp associ well conserv dual function dna bind protein peptidas pepa cell membran interact present nutrient limit growth condit due post translat modif three lysin singl face crp although coincid dna bind rare dissoci crp result increas pepa occup mani chromosom bind site differenti regul hundr gene includ sever encod cyclic dinucleotid phosphodiesteras show pepa repress biofilm format activ motilitychemotaxi propos model membran bound crp interfer pepa dna bind nutrient limit pepa releas togeth crp free pepa activ transcript respons impel bacterium seek hospit environ work uncov function crp sequestr regulatori protein broad describ paradigm bacteri transcriptom modul metabol regul associ transcript factor cell membran
|
D002373;D014734
|
T123;T007;T116
|
36,343,261
|
crispr base engin phage situ bacteri base edit investig microbi gene function essenti elucid ecolog role complex genet interact take place microbi communiti microbiom studi increas preval lack viabl situ edit strategi imped experiment progress render genet knowledg manipul microbi communiti larg inaccess demonstr util phage deliv crispr cas payload perform target genet manipul within communiti context deploy fabric ecosystem ecofab analog soil microbiom first detail engin two classic phage communiti edit use recombin replac nonessenti gene cas base select show effici engin demonstr express antibiot resist fluoresc gene engin prophag within escherichia coli host next modifi express apobec base cytosin base editor cbe leverag perform c point mutat guid modifi cas contain singl activ nucleolyt domain ncas strateg introduc base substitut creat prematur stop codon frame inactiv chromosom lacz plasmid encod gene mcherri ampicillin resist without perturb surround genom region furthermor use multigenera synthet soil communiti employ phage assist base edit induc host specif phenotyp alter communiti context vitro within ecofab observ edit effici across bacteri popul concurr use synthet microbi communiti soil matrix ecofab devic provid control reproduc model close approxim situ edit soil microbiom
|
D000072669;D001435
|
T063;T005
|
36,343,260
|
function genom octn variant inform protein specif variant effect predictor carnitin transport defici genet variant slca encod membran carnitin transport octn caus rare metabol disord carnitin transport defici ctd ctd potenti lethal action detect earli confirmatori diagnosi involv sequenc slca interpret missens variant uncertain signific vuss major challeng studi sought character largest set date n octn variant identifi divers ancestr popul goal further understand mechan lead octn loss function lof creat protein specif variant effect predict model octn function uptak assay c carnitin reveal variant signific reduc transport carnitin compar wild type octn variant sever reduc function less ancestr popul harbor lof variant green fluoresc protein gfp tag variant impair octn local plasma membran human embryon kidney hekt cell subcellular local signific associ function reveal major lof mechan interest ctd data train model classifi variant function gt function lof lt function model outperform exist state art method evalu multipl perform metric mean area receiv oper characterist curv auroc summari studi generat rich dataset octn variant function local reveal import diseas caus mechan improv upon machin learn base predict octn variant function aid variant interpret diagnosi treatment ctd
|
D027701;D002331
|
T123;T121;T116;T127;T109
|
36,343,259
|
genet encod bret probe shed light ligand bias induc variabl ion select trpv px whether ion channel experi ligand depend dynam ion select remain critic import sinc could support ion channel function bias track select ion permeabl ion channel howev remain challeng even patch clamp electrophysiolog studi develop high sensit bioluminesc reson energi transfer bret probe provid dynam measur ca k concentr ionic strength nanoenviron transient receptor potenti vanilloid channel trpv px channel pore real time live cell drug challeng result indic amg bctc amg three well known trpv inhibitor potent inhibit capsaicin cap induc ca influx cap induc k efflux trpv even strike found amg inject alon partial agonist k efflux trpv trigger trpv depend cell membran hyperpolar effort exemplifi ligand bias famili cation channel use bret base strategi also detect concentr time depend ligand bias px px cation select activ benzoyl adenosin triphosph bz atp custom engin bret base probe open avenu ad valu ion channel drug discoveri platform take ligand bias account
|
D050051
|
T123;T116
|
36,343,258
|
slca key amino acid supplier metabol program sustain homeostasi activ type innat lymphoid cell group innat lymphoid cell ilc innat counterpart helper th cell maintain tissu homeostasi respond injuri rapid interleukin il il secret ilc depend avail arginin branch chain amino acid sustain cellular fit prolifer cytokin secret steadi state upon activ howev contribut amino acid transport ilc function known found ilc select express slca encod transport arginin larg amino acid slca express ilc tissu specif manner steadi state increas upon activ genet ablat slca lymphocyt reduc frequenc ilc suppress il il product upon stimul impair type immun respons helminth infect consist slca defici ilc also fail induc cytokin product recruit eosinophil model allerg lung inflamm mechanist reduc amino acid avail due slca defici led compromis mitochondri oxid phosphoryl well impair activ mammalian target rapamycin c myc signal pathway find identifi slca key supplier amino acid metabol program underpin fit activ ilc
|
D007113;D008214
|
T032;T025
|
36,343,257
|
tau prion featur neuropathogenesi syndrom syndrom ds caus triplic chromosom common chromosom disord human individu ds live beyond age develop progress dementia similar alzheim diseas ad ds ad brain exhibit numer extracellular amyloid plaqu compos intracellular neurofibrillari tangl compos tau sinc ad doubl prion disord ask tau prion featur ds frozen brain peopl ds famili ad fad sporad ad sad age match control procur brain biorepositori select precipit tau prion ds brain homogen measur number prion use cellular bioassay brain extract deceas donor ds rang age found near ds brain readili measur level tau prion cross section analysi ds donor age death found level tau prion increas age contrast ds brain level tau prion brain fad sad donor decreas function age death whether ds ideal model assess efficaci putat ad therapeut remain determin
|
D011328;D004314;D000544
|
T005;T048;T116;T047
|
36,343,256
|
neuropeptid signal confer ethanol state depend olfactori learn caenorhabd elegan alcohol intox impact learn may contribut develop problemat alcohol use alcohol ethanol induc state depend learn sdl inform learn anim intox recal effect subject test similar intox test intox caenorhabd elegan undergo olfactori learn ol intox learn becom state depend recal ol appar anim test intox found two gene known requir signal integr secret peptid hen receptor tyrosin kinas scd requir sdl express hen aser neuron scd aia neuron suffici function sdl optogenet activ aser absenc ethanol learn could confer ethanol state depend indic aser activ suffici signal ethanol intox ol circuit surpris aser activ test substitut ethanol intox demonstr effect ethanol learn recal reli distinct signal addit intox state inform could ad alreadi establish ol state depend ol lose state inform intox signal remov final dopamin requir state depend ol found activ aser bypass requir find provid window modul learn ethanol suggest ethanol act modifi learn use mechan distinct use memori access
|
D000435;D029742;D009479;D000437
|
T123;T116;T048
|
36,343,255
|
assess effect radiat forc aerosol cloud interact global ocean cloud respond anthropogen sulfat aerosol one largest sourc uncertainti radiat forc climat industri era uncertainti limit abil predict equilibrium climat sensit ec equilibrium global warm follow doubl atmospher co use satellit observ quantifi relationship sulfat aerosol low level cloud care control meteorolog combin relationship estim chang sulfat concentr sinc constrain associ radiat forc estim cloud mediat radiat forc anthropogen sulfat aerosol formula see text w global ocean confid constraint impli ec like k confid result indic aerosol forc less uncertain ec probabl larger rang propos recent climat assess
|
D002980;D055904
|
T090;T070
|
36,343,254
|
stage specif transposon activ life cycl fairi ring mushroom marasmius oread genet variabl generat differ mechan across life cycl mani basidiomycet fungi extend somat stage cell carri two genet distinct haploid nuclei dikaryosi result fusion two compat monokaryot individu recent find reveal remark genom stabil nucleotid level dikaryot growth organ whether pattern extend mutat affect larg genom region remain unknown furthermor despit high genom integr dikaryosi basidiomycet popul devoid genet divers beg question divers introduc use marasmius oread fairi ring investig rise larg scale variant mono dikaryosi separ two nuclear genotyp four fruit bodi generat complet genom assembl gain access investig genom chang size found dikaryot growth natur genom stay intact separ nucleotyp monokaryon consider amount structur variat start accumul driven larg extent transposon transposon insert also found monokaryot singl meiospor isol henc show genom integr basidiomycet interrupt monokaryosi lead genom rearrang increas activ transpos element suggest genet diversif disproportion life cycl stage mushroom form fungi short live monokaryot growth stage prone genet chang dikaryot stage
|
D055433;D001487;D000363
|
T004
|
36,343,253
|
structur npas arnt npas arnt heterodim reveal new dimer modal bhlh pas transcript factor famili neuron per arnt sim pas domain protein npas protect transcript regul whose dysfunct link varieti neuropsychiatr metabol diseas member basic helix loop helix per arnt sim bhlh pas transcript factor famili npas distinguish abil form function heterodim aryl hydrocarbon receptor nuclear transloc arnt arnt also bhlh pas famili member describ quaternari architectur npas arnt npas arnt heterodim complex involv dna respons element crystallograph studi reveal uniqu interconnect domain conform npas protein well differenti configur heterodimer arrang arnt arnt notabl pas domain arnt arnt exhibit variabl conform within two heterodim arnt pas domain also form set interfac pas pas b domain npas differ previous note arnt heterodim form class bhlh pas famili protein structur observ togeth biochem cell base interrog npas heterodim provid molecular glimps npas protein architectur extend known repertoir heterodimer pattern within bhlh pas famili pas b domain npas arnt arnt contain ligand access pocket appropri volum requir small molecul bind given npas linkag human diseas direct visual pas domain understand relat posit interconnect within npas arnt npas arnt heterodim may provid road map therapeut discoveri target complex
|
D051792;D051784
|
T123;T116
|
36,343,252
|
odd even effect thermal conduct liquid crystallin epoxi resin rapid develop high perform comput high power electron drive need high thermal conduct polym composit encapsul interfac materi howev polym typic low thermal conduct w k studi thermal conduct seri epoxi resin cure one diamin harden seven diepoxid monom differ precis ethylen linker length x found pronounc odd even effect ethylen linker length liquid crystallin order mass densiti thermal conduct epoxi resin even x liquid crystallin structur highest densiti gcm highest thermal conduct w k epoxi resin odd x amorph lowest densiti gcm lowest thermal conduct w k find indic control precis linker length dens network power rout molecular design thermal conduct polym
|
D004853;D050866
|
T104;T122;T073
|
36,343,251
|
direct takeoff aerial right adhes land semiaquat springtail springtail collembola tradit portray explos jumper incipi direct takeoff uncontrol land howev collembolan live near water skill crucial evad host voraci aquat terrestri predat discov semiaquat springtail isotomurus retardatus perform direct jump rapid aerial right near perfect land water surfac achiev locomot control adjust bodi attitud impuls takeoff deform bodi midair exploit hydrophil ventral tube known collophor experi mathemat model indic direct impuls control takeoff driven collophor adhes forc bodi angl stroke durat produc jump organ furcula midair springtail curv bodi form u shape pose leverag aerodynam forc right less ms fastest ever measur anim stabl equilibrium facilit water adher collophor aerial right confirm place springtail vertic wind tunnel physic model due aerial respons springtail land ventral side time anchor via collophor water surfac avoid bounc valid springtail biophys principl bioinspir jump robot reduc flight rotat land upright time thus contrari common belief wingless hexapod jump skydiv land outstand control fundament surviv
|
D001181
|
T204
|
36,343,250
|
silenc rnas express w link pxymasc retrocopi target gene femal sex determin plutella xylostella lepidoptera insect order cultur econom environment import repres describ live speci yet one speci silkmoth bombyx mori molecular genet sexual fate determin remain unknown investig diamondback moth plutella xylostella global import high invas econom damag pest crucifer crop previous work uncov regul male sex determin p xylostella pxymasc homolog b mori masculin although initi express embryo sex reduc femal embryo lead femal specif splice doublesex sequenc small rna librari generat earli embryo sex larval pool identifi varieti small silenc rnas predomin piwi interact rnas pirna complementari pxymasc whose tempor express correl reduct pxymasc transcript observ previous femal analysi small rnas show express tandem arrang multicopi array found exclus w femal specif chromosom term pxyfem analysi pxyfem sequenc show partial complementari dnas cdnas pxymasc messeng rna mrna transcript like integr transpos element graveyard noncanon action retrotransposon retrocopi appar similar b mori femin probabl repres converg evolut studi help elucid sex determin cascad global import pest highlight shortcut retrotransposit event facilit evolut complex molecular cascad includ sex determin
|
D012831;D009036
|
T204
|
36,343,249
|
workflow annot knowledg gap metabol reconstruct use known hypothet reaction advanc medicin biotechnolog reli deep understand biolog process despit increas avail type amount omic data signific knowledg gap remain current approach identifi curat miss annot limit set alreadi known reaction introduc network integr comput explor gap annot metabol nicegam workflow identifi curat nonannot metabol function genom use atlas biochemistri genom scale metabol model gem resolv gap gem nicegam provid altern set known hypothet reaction assess thermodynam feasibl suggest candid gene catalyz reaction identifi metabol gap appli nicegam latest gem escherichia coli iml enhanc e coli genom annot resolv gap nicegam applic gem function open sourc softwar thus enhanc gem base predict subsequ biotechnolog biomed applic
|
D053858;D004926
|
T007;T169;T044
|
36,343,248
|
environment driver first major anim extinct across ediacaran white sea nama transit ediacara biota oldest communiti complex macroscop fossil consist three tempor distinct assemblag avalon ca white sea ca nama ca generic divers vari among assemblag notabl declin transit white sea nama preserv sampl bias biotic replac environment perturb propos potenti mechan drop divers compil global databas ediacara biota specif target taphonom paleoecolog charact test hypothes major ecolog shift feed mode life habit tier level accompani increas generic rich avalon white sea assemblag find white sea taxa absent nama interv compar loss phanerozo mass extinct paleolatitud deposit environ preserv mode character white sea assemblag well repres nama indic declin result sampl bias counter expect biotic replac model minim ecolog differ two assemblag howev taxa disappear exhibit varieti morpholog behavior charact consist environment driven extinct event preferenti surviv taxa high surfac area relat volum may suggest relat reduc global ocean oxygen avail thus data support link ediacaran biotic turnov environment chang similar major mass extinct geolog record
|
D005075;D005580
|
T045;T167
|
36,343,247
|
trend inequ preval dementia unit state paper present estim preval dementia unit state age sex race ethnic educ measur lifetim earn use data individu age older person year observ nation repres survey health retir studi hrs survey includ rang cognit test subsampl underw clinic assess dementia develop longitudin latent variabl model cognit status estim use markov chain mont carlo method model provid accur estim dementia preval popul subgroup previous use method hrs age adjust preval dementia decreas ci popul statist signific declin percentag point femal like live dementia sex differ narrow male subsampl found reduct inequ across educ earn racial ethnic group among femal inequ also declin less strong observ substanti increas level educ sampl composit chang explain statist sens reduct dementia preval among men among women wherea composit chang older popul age race ethnic cardiovascular risk factor matter less
|
D005006;D003704
|
T098;T102;T048
|
36,343,245
|
sox sox control fluid homeostasi inner ear hear independ cooper mechan vivo mechan under domin syndrom caus mutat sri box transcript factor sox sox sox transcript factor either express alon coexpress ill defin creat mous model campomel dysplasia soxyx mutat truncat transactiv domain leav dna bind dimer intact find soxyx caus deaf via distinct mechan endolymphat sac es duct cochlea contrast condit heterozyg sox null mice normal es develop soxyx heterozygot sox gene import ionic homeostasi regul development persist progenitor result fewer matur cell sox heterozyg null mutant also display persist esduct progenitor contrast sox retain express earli soxyx mutant cochlea later postnat stria vasculari domin interfer soxyx implic impair normal cooper sox sox repress express water channel aquaporin therebi contribut endolymphat hydrop studi show function endolymphat system inner ear sox regul sox depend cell type target gene work either independ cooper sox soxyx interfer activ sox factor exert effect classifi haploinsufficienthypomorph domin negat depend cellgen context model disrupt transcript factor partnership may applic congenit deaf affect newborn syndrom disord
|
D007758;D003638
|
T033;T184;T023;T047
|
36,343,244
|
superenhanc drive tumor specif splice variant marco promot tripl negat breast cancer progress transcript variat lead various form transcript protein divers remain larg unexplor tripl negat breast cancer tnbcs present comprehens analysi rna splice breast cancer illustr biolog function clinic implic tumor specif transcript tsts aris splice junction aberr rna splice tsts frequent harbor tnbc correl poor outcom discov tumor specif splice variant macrophag receptor collagen structur tst marco tst distinguish myeloid cell specif wild type marco marco tst express associ poor outcom tnbc patient could promot tumor progress vitro vivo mechan marco tst interact plod enhanc stabil hif result metabol dysregul tnbc form hypox tumor microenviron marco tst initi de novo altern transcript initi site activ superenhanc tumor marco tst express confer greater sensit bromodomain extratermin protein inhibitor treatment strategi valid patient deriv organoid conclus result reveal transcript variat landscap tnbc highlight marco tst crucial oncogen transcript therapeut target
|
D064726
|
T191
|
36,343,243
|
phloretin enhanc remyelin stimul oligodendrocyt precursor cell differenti failur remyelin under progress natur demyelin diseas multipl sclerosi endogen repair mechan frequent fail disord poor understood howev evid indic relat over inflammatori microenviron combin intrins inabl oligodendrocyt precursor cell opc differenti matur myelin cell previous found phloretin flavonoid abund present appl strawberri reduc neuroinflamm drive macrophag toward antiinflammatori phenotyp show phloretin also mark stimul remyelin ex vivo vivo anim model improv remyelin attribut direct impact phloretin opc matur occur independ alter microglia function inflamm found mechanist phloretin act direct ligand fatti acid sens nuclear receptor peroxisom prolifer activ receptor gamma therebi promot matur opc togeth find indic phloretin proregen properti central nervous system disord potenti broad implic develop therapeut strategi dietari intervent aim promot remyelin
|
D000074586;D000073637
|
T025;T043
|
36,343,241
|
protect regul state human brain possibl lesson covid covid pandem creat larg popul patient slow recov conscious follow mechan ventil sedat intens care unit clinic scenario compar possibl except rare patient post cardiac arrest coma minim structur brain injuri recov cognit motor function prolong delay common electroencephalogram eeg signatur seen patient burst suppress biophys model shown burst suppress like signatur neurometabol state preserv basic cellular function state lower energi avail state like act brain protect mechan similar eeg pattern observ anoxia resist paint turtl present conceptu analysi interpret brain state covid patient suffer prolong recoveri conscious begin ching model integr find clinic scenario studi anoxia toler physiolog paint turtl postul prolong recoveri conscious covid patient could reflect effect modest hypox injuri neuron unmask latent neuroprotect mechan human brain putat protect regul state appear similar observ paint turtl suggest new approach enhanc coma recoveri
|
D003128;D000086382
|
T047;T067;T048
|
36,343,240
|
activ adjust crime rate show public safeti worsen paper argu chang human activ covid pandem led unusu diverg crime rate victim risk us citi violent crime declin pandem howev analysi use data activ show risk street crime victim elev throughout peopl public space like rob assault increas unlik explain chang crime report select outdoor activ potenti victim tradit crime rate may present mislead view recent chang public safeti
|
D000086382;D019548
|
T068;T047;T098;T067
|
36,343,239
|
mode pangean lake level cyclic driven astronom climat pace modul continent posit pco formula see text orbit cyclic fundament pacemak earth climat system newark hartford basin nhb lake sediment record eastern north america contain compel geolog express cyclic reflect variat climat condit tropic pangea late triassic earliest jurass climat model enabl deeper mechanist understand earth system modul uniqu greenhous supercontin period link major featur nhb record combin climat effect orbit forc paleogeograph chang atmospher pco formula see text variat ensembl transient orbit driven climat simul assess nine time slice three atmospher pco formula see text valu two paleogeograph reconstruct climat transit tropic humid season ultim semiarid associ tecton drift nhb formula see text formula see text model orbit modul precipit evapor balanc pronounc interv wherea limit weak season increas arid interv lower pco formula see text around contribut drier climat could led observ damp sediment cyclic eccentr modul precess domin orbit driven climat respons nhb region high obliqu amplifi summer precipit season shift tropic rainfal belt region proxi record also assess provid guidanc toward integr pictur global astronom climat forc late triassic ultim period earth histori
|
D060106;D018534
|
T083;T070
|
36,343,238
|
tool monitor cell type specif focus ultrasound neuromodul control chronic epilepsi focus ultrasound fus power tool noninvas modul deep brain activ promis therapeut potenti refractori epilepsi howev tool examin fus effect specif cell type within deep brain yet exist consequ cell type within heterogen network modul whether paramet identifi bias network context complex behavior remain unknown address develop fiber photometri coupl focus ultrasound system phocus simultan monitor fus effect neural activ subcort genet target cell type freeli behav anim identifi paramet set select increas activ parvalbumin interneuron suppress excitatori neuron hippocampus net inhibitori effect local hippocampus confirm whole brain metabol imag final inhibitori select paramet achiev signific spike suppress kainat model chronic tempor lobe epilepsi open door futur noninvas therapi
|
D004827;D004833
|
T033;T047
|
36,343,237
|
close loop microstructur charg transport conjug polym combin microscopi simul grand challeng materi scienc identifi impact molecular composit structur across rang length scale macroscop properti demonstr unifi experiment theoret framework coordin experiment measur mesoscal structur molecular level physic model bridg multipl scale physic behavior appli framework understand charg transport semiconduct polym spatial resolv nanodiffract transmiss electron microscop combin self consist framework polym chain statist yield detail pictur polym microstructur rang molecular devic relev scale use data input charg transport calcul combin multiscal approach highlight underrepres role defect exist transport model short rang transport shown chaotic often pictur drift veloc account small portion overal charg motion local transport sensit align geometri polym chain longer length scale larg domain gradual grain boundari funnel charg preferenti certain region creat inhomogen charg distribut align general improv mobil funnel effect negat impact mobil microstructur modifi silico explor possibl design rule show chain stiff align benefici local homogen posit effect combin approach creat flexibl extens pipelin analyz multiscal function properti general strategi extend acces length scale experiment theoret probe har combin strength
|
D011108;D012666
|
T104;T122;T073
|
36,343,236
|
midbrain dopamin neuron arbit ocd like behavior neurobiolog understand obsess compuls disord ocd includ dysregul frontostriat circuitri alter monoamin transmiss repetit stereotyp behavior eg groom featur symptom ocd propos associ perturb dopamin da signal howev precis brain circuit particip da control behavior phenotyp remain elus identifi da neuron substantia nigra par compacta snc orchestr ventromedi striatum vms microcircuit well later orbitofront cortex lofc self groom behavior snc vms snc lofc dopaminerg project modul groom behavior striatal microcircuit function differenti specif activ snc vms pathway promot groom via receptor wherea activ snc lofc pathway suppress groom via receptor snc da neuron activ thus control ocd like behavior via striatal cortic project dual gate result support pharmacolog brain stimul treatment ocd
|
D059290;D009771
|
T025;T048
|
36,343,235
|
theori tip structur depend microtubul catastroph damag induc microtubul rescu microtubul essenti cytoskelet polym exhibit stochast switch tubulin assembl disassembl examin possibl mechan switch call catastroph rescu formul four state mont carlo model explicit consid two biochem two conform state tubulin base recent conceiv view microtubul assembl flare end model predict high activ energi barrier later tubulin interact caus lag curl protofila lead rag appear grow tip chang extent tip ragged explain import poor understood featur microtubul catastroph weak depend tubulin concentr increas probabl time known age model predict vanish rare frequenc spontan rescu unless patch guanosin triphosph tubulin artifici embed microtubul lattic test model use vitro reconstitut design minim artifact induc microtubul interact nearbi surfac microtubul assembl seed overhang microfabr pedest thus well separ coverslip geometri reduc rescu frequenc incorpor tubulin microtubul shaft compar convent assay produc data consist model moreov rescu posit microtubul nucleat coverslip immobil seed display nonexponenti distribut confirm coverslip affect microtubul dynam overal studi establish unifi theori account microtubul assembl flare end tip structur depend catastroph frequenc microtubul rescu frequenc depend lattic damag repair
|
D014404;D008870
|
T026;T123;T116
|
36,343,234
|
dynam plosiv conson via imag comput soft electron quantit understand coupl dynam flow particl aerosol droplet transmiss associ speech remain elus summar effort integr insight flow particl dynam induc product plosiv sound speech skin integr electron system monitor product sound particular uncov diffus ballist regim separ threshold particl size character lagrangian acceler pair dispers lagrangian dynam particl diffus regim exhibit featur isotrop turbul fundament find highlight valu skin interfac wireless sensor continu measur critic speech pattern clinic set work environ home base uniqu neck biomechan associ generat plosiv sound introduc wireless soft devic captur motion enabl detect plosiv sound multipl languag convolut neural network approach work span fundament flow particl physic soft electron technolog implic monitor studi critic speech pattern associ aerosol droplet transmiss relev spread infecti diseas
|
D013060;D004581
|
T090;T040;T054
|
36,343,233
|
direct evolut identifi high affin cystin knot peptid agonist antagonist wnt catenin signal develop peptid base tool fine tune growth signal pathway particular molecul exquisit select high affin open opportun cellular reprogram tissu regener present librari base cystin knot peptid ckps incorpor multipl loop random select via direct evolut result binder could assembl multimer structur fine tune cellular signal exampl present wnt pathway play key role homeostasi regener tissu lung skin intestin discov picomolar affin ckp agonist human lpr receptor explor limit topolog manipul lrp dimer structur analys reveal agonist bind first propel domain lrp mimick natur wnt inhibitor dkk sost howev ckp agonist exhibit differ mode action amplifi signal natur wnt ligand activ pathway alveolospher organoid model ckp agonist induc alveolar stem cell activ also stimul growth primari human intestin organoid approach describ advanc import frontier next generat agonist design could appli signal pathway discov tunabl agonist ligand
|
D060449;D051176
|
T123;T116;T044
|
36,343,231
|
neuropeptid ff indirect affect testicular morphogenesi function medaka testicular morphogenesi function consid control neural endocrin system howev avail literatur main limit mammal remain unclear regul teleost speci demonstr neuropeptid ff npff brain respons follicl stimul hormon express pituitari facilit testicular morphogenesi androgen synthesi subsequ contribut success spermatogenesi present find give us import insight neuroendocrin regulatori mechan under testicular morphogenesi function teleost
|
D009990
|
T013
|
36,343,230
|
systemat reduct dimension natur scene allow accur predict retin ganglion cell spike output mammalian retina engag broad array linear nonlinear circuit mechan convert natur scene retin ganglion cell rgc spike output although mani individu integr mechan well understood know less multipl mechan interact encod complex spatial featur present natur input identifi key spatial featur natur scene shape encod primat parasol rgcs approach identifi simplif spatial structur natur scene minim alter rgc spike respons observ reduc natur movi linear integr region describ structur parasol rgc spike respons perform depend number region precis spatial locat use simplifi stimuli design high dimension metam recapitul respons naturalist movi final model retin comput convert flash natur imag one dimension spike count
|
D012165;D012160
|
T023;T025
|
36,343,229
|
new chronolog mori settlement aotearoa nz potenti role climat chang demograph develop understand role climat chang resourc avail popul growth human mobil remain critic import anthropolog research linkag climat demograph chang short settlement histori aotearoa new zealand requir tempor precis equival period singl generat howev current model approach frequent use small terrestri radiocarbon dataset practic obscur past mori popul pattern connect chang climat systemat analysi terrestri marin c age enabl robust assess largest dataset yet collat island context analysi made possibl recent develop tempor marin correct southern pacif water find show shortcom previous model demonstr human settlement mid late th centuri ad unambigu highlight initi ad settlement north island south island reach decad later ad hunt giant flightless moa commenc ad popul grew rapid popul growth level around ad declin ad synchron onset littl ice age moa loss essenti food sourc popul continu grow econom stabl north condit horticultur optim enhanc precis research afford robust analysi marin date open uniqu opportun investig interconnect polynesia inform pattern seen island context
|
D057231;D044468
|
T098;T070
|
36,343,228
|
spinal neuropeptid receptor express neuron pharmacotherapeut target allevi neuropath pain peripher nerv injuri sensit complex network spinal cord dorsal horn dh neuron produc allodynia neuropath pain identif druggabl target within network remain elus promis candid neuropeptid npi receptor express interneuron popul report spare nerv injuri sni enhanc excit in elicit allodynia mechan cold hypersensit affect pain similar chemogenet optogenet activ in uninjur mice elicit behavior sign spontan allodyn affect pain sni induc allodynia reduc chemogenet inhibit in intrathec administr select agonist condit delet npyr dh neuron peripher affer neuron prevent anti hyperalges effect intrathec agonist conclud spinal in necessari suffici behavior symptom neuropath pain repres promis target futur pharmacotherapeut develop agonist
|
D006930;D009437
|
T184;T047
|
36,343,227
|
satellit map urban built height reveal extrem infrastructur gap inequ global south inform urban built infrastructur essenti understand role citi shape environment econom social outcom lack data built height larg area limit abil character urban infrastructur spatial variat across world develop global atlas urban built height circa resolut sentinel ground rang detect satellit data result show extrem gap per capita urban built infrastructur global south compar global averag even larger gap compar averag level global north per capita urban built infrastructur countri global north time higher global south result also show built infrastructur countri global north combin global popul rough equival countri global south global popul inequ urban built infrastructur measur inequ index larg countri largest global south compar global north analysi reveal scale infrastructur demand global south requir order meet sustain develop goal
|
D000076502
|
T078;T068;T067
|
36,343,226
|
inform flow gate energet dimer molecular motor molecular motor kinesin myosin dimer consist two link ident monomer globular protein fuel free energi generat atp hydrolysi walk polar track microtubul filament actin process mean one head detach execut mechan step stay bound track one motor head must regul chemic state refer gate concept still fulli understood inspir experi show fraction energi atp hydrolysi use advanc kinesin motor load demonstr rest energi associ chemic transit two head coordin chemic transit involv communic two head featur character gate develop general framework base inform theori stochast thermodynam establish gate could quantifi term inform flow motor head applic kinesin myosin v show inform flow posit cooper extern resist load less critic valu fc forc exceed fc effect inform flow ceas interest fc independ input energi generat atp hydrolysi coincid forc probabl backward step start increas find suggest transport effici optim forc less fc impli motor must oper low load vivo condit
|
D016547;D000255
|
T123;T121;T116;T126;T114
|
36,343,225
|
microfluid guid deep learn cancer immunotherapi screen immunocyt infiltr cytotox play critic role inflamm immunotherapi howev current cancer immunotherapi screen method overlook capac cell penetr tumor stroma therebi signific limit develop effect treatment solid tumor present autom high throughput microfluid platform simultan track dynam cell infiltr cytotox within tumor cultur tunabl stromal makeup recours clinic tumor infiltr lymphocyt til score analyz base clinic data driven deep learn method platform evalu efficaci treatment base score cell infiltr pattern screen drug librari use technolog identifi epigenet drug lysin specif histon demethylas inhibitor lsdi effect promot cell tumor infiltr enhanc treatment efficaci combin immun checkpoint inhibitor anti pd vivo demonstr autom system strategi screen immunocyt solid tumor interact enabl discoveri immuno combin therapi
|
D000077321;D009369
|
T191;T066
|
36,343,224
|
switchabl target solid tumor bscar cell develop chimer antigen receptor car cell therapi becom critic mileston modern oncotherapi despit remark vitro effect problem safeti efficaci car cell therapi solid tumor challeng lack tumor specif antigen requir avoid target tumor effect spatial separ cytotox function car cell tumor antigen recognit provid protein mediat allow precis control car cell cytotox high affin capabl bacteri toxin antitoxin barnas barstar system adopt guid car cell solid tumor complementari modul base ankyrin repeat darpin barnas protein barstar base car bscar design provid switchabl target tumor cell alter darpin barnas switch enabl target differ tumor antigen singl bscar gradual increas cytokin releas tunabl bscar cell cytotox achiev vari darpin barnas load switchabl bscar cell therapi abl erad ductal carcinoma vivo guid bscar cell darpin barnas switch provid univers approach control multitarget adopt immunotherapi
|
D013601;D009369
|
T191;T025
|
36,343,219
|
wolbachia induc cytoplasm incompat common cytoplasm incompat ci common reproduct manipul produc wolbachia oblig intracellular alphaproteobacteria infect approxim half insect speci infect frequenc within host popul approach intens ci drive wolbachia near fixat within generat howev natur select among wolbachia variant within individu host popul favor enhanc ci inde variant caus ci increas host fit reliabl matern transmit expect spread infect femal remain protect ci nevertheless approxim half analyz wolbachia infect caus detect ci frequenc persist ci plausibl explain preferenti spread new host speci clade select rather natur select among variant within host popul ci caus wolbachia lineag preferenti spread new host speci ci increas equilibrium wolbachia frequenc within host popul ci caus variant remain high frequenc within popul even condit chang initi benefici wolbachia infect becom harm epidemiolog model describ wolbachia acquisit loss host speci loss ci induct within wolbachia lineag yield simpl express incid wolbachia infect fraction infect caus ci support determin role differenti interspecif spread maintain ci mani wolbachia infect recent acquir host speci mani show evid contemporari spatial spread retreat rapid evolut ci induc loci especi degrad common
|
D020577
|
T007
|
36,343,198
|
drop cours persist onlin undergradu nurs program recent studi link drop cours increas likelihood persist nurs educ studi examin associ drop cours demograph characterist persist among onlin undergradu nurs student
|
D004508;D013338;D020375;D004506
|
T065;T097
|
36,343,197
|
prevent problemat miss data cours encourag communiti adopt increas effect method mitig harm miss data pose valid scienc nurs educ last column entri year conclud emphasi look approach prevent problemat missing implement prior collect data j nur educ
|
D004506
|
T065
|
36,343,195
|
use curriculum map promot licens practic nurs attain baccalaur nurs degre increas number baccalaur prepar nurs effort focus degre complet rns less attent given foster baccalaur nurs bsn degre pathway licens practic nurs lpns facilit develop lpn bsn degre pathway faculti one bsn program use curriculum map form inquiri
|
D065102;D004508
|
T065;T097
|
36,343,194
|
effect perceiv risk contract covid nurs student well although mental health symptom increas coronavirus diseas covid pandem littl known associ nurs student perceiv risk contract covid academ psycholog well studi examin associ perceiv covid risk likelihood complet nurs educ mental health factor nurs student
|
D013338;D000086382
|
T047;T067;T097
|
36,343,193
|
leadership self mean efficaci among nurs faculti nation studi call leadership everi nurs role thus nurs faculti must self reflect leadership abil seek support surround resourc success leader current futur role
|
D005181;D004506
|
T065;T097
|
36,343,192
|
holocaust genocid studi nurs educ nurs practition critic intellectu nurs school holocaust genocid studi part curriculum howev studi past horror involv health care profession essenti form clear moral compass navig futur nurs practic articl analyz uniqu holocaust genocid curriculum graduat nurs practition student effect particip
|
D017767;D004506;D009722;D063365;D013338
|
T065;T054;T052;T097
|
36,343,191
|
job satisfact among nurs faculti canada unit state higher educ want satisfi workforc ensur organ reach state evolv goal howev faculti dissatisfi harm long term consequ product organiz outcom studi examin nurs faculti job satisfact intent stay univers unit state canada
|
D005181;D007588
|
T041;T097
|
36,343,190
|
peer mentor call creat inclus program support student abil success support divers nurs student need built exist peer mentor program foster success student
|
D000071252;D004508;D013338
|
T065;T097
|
36,343,182
|
palpit dizzi syncop teenag girl practic approach pediatr cardiologist palpit dizzi syncop common seem healthi teenag girl unfortun symptom rais signific concern patient famili present diagnost challeng health care provid result unhelp expens test unnecessari restrict patient possibl serious under patholog may prompt referr pediatr subspecialist includ cardiolog articl present relev background principl practic guidelin perspect pediatr cardiologist element initi person famili medic histori physic examin often distinguish benign condit nefari one direct limit addit test ultim confirm presenc absenc heart diseas addit whether symptom due condit serious benign everi patient benefit intervent sometim simpl educ reassur behavior dietari modif medic invas procedur referr health care provid pediatr ann e e
|
D000072096;D006331
|
T047;T097
|
36,343,181
|
review current evalu manag strategi pediatr postacut sequela covid pediatr postacut sequela covid ppasc long covid complex heterogen multisystem syndrom lead disrupt live children adolesc month possibl year recoveri acut sar cov sever acut respiratori syndrom coronavirus infect under pathophysiolog mechan pasc still investig clinician face immedi challeng treat patient articl provid overview current multidisciplinari evalu patient ppasc also offer guidanc medic psycholog rehabilit manag strategi base experi ppasc patient postvir syndrom pediatr ann e e
|
D000086382
|
T047;T067
|
36,343,180
|
pediatr long covid review definit epidemiolog present pathophysiolog although children larg spare sever consequ acut infect sar cov virus estim one quarter million children diagnos coronavirus diseas covid develop persist symptom fatigu postexert malais neurolog cognit symptom symptom interfer activ daili live month initi ill pediatr postacut sequela covid ppasc long covid complex heterogen postvir condit involv multipl bodi system like attribut sever concurr under physiolog process includ damag direct viral invas endovascular dysfunct microthrombosi viral persist develop autoimmun review explor current state literatur regard definit epidemiolog clinic present propos pathophysiolog mechan ppasc pediatr ann e e
|
D000086382
|
T047;T067
|
36,343,179
|
emerg vaccin prevent diseas perfect storm hesit refus pandem war landscap pediatr vaccin chang dramat due chang attitud toward immun recent world event rise vaccin hesit refus relat concurr rise social media anti vaccin messag misinform campaign led popul children unimmun immun popul left vulner rapid spread vaccin prevent infect addit sever acut respiratori syndrom coronavirus sar cov clinic syndrom known coronavirus diseas covid result emerg worldwid pandem control measur mitig spread covid result numer report children miss routin vaccin along stop mani public health immun program final arm conflict war led larg famili migrat homeland various countri region lead increas risk miss matern child immun well difficulti keep vaccin record pediatr ann e e
|
D000079263;D000086382;D014612
|
T129;T121;T116;T067;T047
|
36,343,177
|
puls oximetri screen congenit heart defect newborn nurseri review general pediatrician congenit heart defect heterogen group disord may present vari way earli life particular import within categori congenit heart defect critic congenit heart defect requir surgeri intervent catheter prostaglandin depend intervent age month year depend definit use time sensit element identifi lesion question rais children affect critic congenit heart defect best identifi one strategi use sinc mid puls oximetri screen assess detect abnorm neonat led improv child health outcom across unit state world articl serv review critic congenit heart defect puls oximetri screen tool general pediatrician care infant pediatr ann e e
|
D010092;D006330
|
T060;T019;T059
|
36,343,176
|
monkeypox global host immun viral evolut creat new pathogen monkeypox orthopoxvirus endem west africa congo basin caus ill character fever myalgia lymphadenopathi dissemin vesicular rash although similar smallpox monkeypox typic milder lower mortal rate endem africa previous reduc owe cross protect smallpox vaccin increas sinc cessat univers vaccin sporad case import unit state us secondari case larg global outbreak demonstr chang epidemiolog increas person person transmiss may return travel massachusett present monkeypox octob case report countri us case younger peopl without previous smallpox vaccin men sex men previous unrecogn mode transmiss pediatr ann e e
|
D045908;D012899;D000072339
|
T047;T098
|
36,343,168
|
effect increas povidon iodin exposur corneal epithelium impact donor rim cultur purpos studi assess effect second povidon iodin pvp applic time donor tissu recoveri overal tissu qualiti analyz rate posit fungal bacteri rim cultur implement increas pvp exposur
|
D011206;D019573
|
T121;T024;T109
|
36,343,164
|
argument prompt corneal cross link diagnosi keratoconus pediatr patient strong evid suggest corneal crosslink safe procedur capabl stop slow progress keratoconus avoid visual loss associ progress delay prevent need corneal transplant progress chronic natur diseas make option prompt crosslink upon keratoconus diagnosi pediatr patient valid
|
D007640;D010778
|
T061;T047
|
36,343,103
|
consum led screen atrial fibril frontier review af screen intern collabor technolog evolut widespread avail wearabl handheld ecg devic capabl screen atrial fibril af promot direct consum focus attent health care profession patient organ consum led af screen frontier review member af screen intern collabor provid critic apprais rapid evolv field increas awar complex uncertainti surround consum led af screen although numer commerci avail devic direct market consum af monitor identif unrecogn af health care profession led random control studi use multipl ecg record continu ecg monitor detect af fail demonstr signific reduct stroke although remain uncertain consum led af screen reduc stroke could increas earli diagnosi af facilit integr approach includ appropri anticoagul rate rhythm manag risk factor modif reduc complic compani market af screen devic report accuraci perform product high low risk popul avoid claim clinic outcom unless improv demonstr random clinic trial general diagnost yield af screen increas number durat tempor dispers screen session prognost import may less af detect singl time point screen larg perman persist high burden paroxysm af consum initi ecg record suggest possibl af alway requir confirm health care profession experienc ecg read wherea suspicion af basi photoplethysmographi must confirm ecg consum led af screen unlik cost effect stroke prevent predomin young earli adopt technolog studi older peopl higher stroke risk requir demonstr effect cost effect direct interact compani consum creat new regulatori gap relat data privaci registr consum app devic although sever barrier optim use consum led screen exist result larg ongo trial power detect clinic outcom requir health care profession support widespread adopt consum led af screen
|
D001281;D020521
|
T047;T046
|
36,343,090
|
studi syndrom rule stagnat heat liver stomach non eros reflux diseas base microecolog tongu coat present pathogenesi non eros reflux diseas nerd still unclear proton pump inhibitor main treatment drug howev effect limit tradit chines medicin treatment nerd advantag stagnat heat liver stomach syndrom import tradit chines medicin syndrom type diseas tongu diagnosi import basi diagnosi stagnat heat liver stomach syndrom microecolog tongu coat suggest occurr develop diseas purpos studi aim clarifi regular chang tongu coat microecolog stagnat heat liver stomach syndrom nerd
|
D005764;D003240
|
T047
|
36,343,089
|
associ low bodi temperatur admiss hospit mortal accord bodi mass index categori patient sepsi hypothermia shown associ high mortal rate among patient sepsi howev relationship hypothermia bodi mass index bmi respect mortal remain elucid conduct studi assess associ hypothermia surviv outcom patient sepsi accord bmi categori secondari analysi prospect cohort studi enrol patient age year sepsi hospit intens care unit japan patient divid bmi categori high kgm bodi temperatur c c group primari outcom hospit mortal rate associ hypothermia bmi categori respect hospit mortal evalu use multivari logist regress analysi patient low normal high bmi valu respect patient bodi temperatur c hypothermia higher hospit mortal rate without hypothermia normal bmi group vs howev true patient low high bmi group signific interact observ hypothermia normal bmi hospit mortal odd ratio confid interv p valu interact howev interact found hypothermia low high bmis patient sepsi hypothermia normal bmi subgroup may higher mortal risk low high bmi subgroup therefor requir attent
|
D007035;D018805
|
T033;T047;T046;T037
|
36,343,088
|
effect cataract surgeri progress age relat macular degener cataract age relat macular degener amd common caus decreas vision blind individu age although surgeri effect treatment cataract may acceler progress amd studi evalu influenc cataract surgeri amd systemat review meta analysi
|
D002387;D008268;D002386
|
T061;T047;T033;T190
|
36,343,087
|
analysi prescript medic rule tradit chines medicin bradyarrhythmia treatment base data mine multipl studi reveal tradit chines medicin tcm prescript provid protect effect cardiovascular system increas heart rate reliev symptom patient bradyarrhythmia china tcm treatment bradyarrhythmia common also effect complementari therapi order understand applic chines medicin bradyarrhythmia analyz medic rule tcm prescript bradyarrhythmia data mine method base previous clinic studi
|
D004365;D027561;D055553
|
T123;T121;T002
|
36,343,086
|
differenti pilocyt astrocytoma medulloblastoma hemangioblastoma diffus weight dynam suscept contrast perfus mri studi aim evalu diagnost perform dynam suscept contrast dsc perfus magnet reson imag appar diffus coeffici adc differenti common posterior fossa tumor pilocyt astrocytoma pa medulloblastoma mb hemangioblastoma hb januari april enrol median age year rang femal year femal year femal patient pa mb hb respect normal relat cerebr blood volum flow nrcbv nrcbf normal mean adc nadcmean calcul volum interest statist compar nadcmean signific higher pa mb pa median rang vs mb p nrcbf signific higher hb pa mb pa vs mb vs hb p nrcbv signific differ tumor type pa vs mb vs hb p pa vs mb p pa vs hb mb vs hb tumor success differenti use algorithm approach threshold valu nrcbv subsequ threshold valu nadcmean dsc paramet nadcmean signific differ pa mb hb algorithm approach combin nrcbv nadcmean may use differenti tumor type
|
D008527;D018325;D001254;D002528;D001932
|
T191
|
36,343,085
|
effect lower limb rehabilit robot various train mode patient stroke random control trial effect robot assist gait train demonstr improv gait recoveri patient stroke aim studi determin effect robot assist gait train various train mode patient post stroke
|
D020233;D012371;D000071939
|
T061;T184;T090;T033;T047
|
36,343,084
|
associ serum albumin level relat metabol factor atrial fibril retrospect studi associ serum albumin alb cardiovascular event well establish relationship atrial fibril af remain controversi studi aim evalu associ alb af chines popul review medic record hospit patient patient af includ af group age sex match patient sinus rhythm histori af includ control group test chi squar test conduct analyz clinic baselin data logist regress analysi conduct assess relationship af alb interrelationship alb analyz pearson correl analys appropri cutoff valu alb af analyz receiv oper characterist curv alb level lower af group control group p multivari adjust alb independ negat associ af odd ratio confid interv p alb level posit correl serum globulin total cholesterol triglycerid low densiti lipoprotein cholesterol high densiti lipoprotein cholesterol serum apolipoprotein serum apolipoprotein b level p negat correl serum creatinin level p optim cutoff valu alb predict af gl sensit specif low alb level independ associ af sinc current studi design establish causal prospect cohort studi need determin find
|
D001281
|
T047;T046
|
36,343,083
|
impact earli mobil durat delirium elder hospit patient retrospect cohort pilot studi develop delirium hospit impair activ daili live elder hospit patient clinic practic earli mobil bed recommend reduc delirium incid hospit stay howev effect earli mobil elder inpati delirium establish yet aim studi investig associ earli mobil durat delirium elder inpati delirium retrospect cohort pilot studi examin particip male femal mean age year develop delirium hospit particip surgic treat non surgic treat classifi earli delay mobil base median number day start mobil compar propens score match adjust baselin characterist addit examin correl number day start mobil durat delirium durat delirium signific shorter earli mobil group particular term sit bed wheelchair use delay mobil group median interquartil rang iqr vs iqr day p median iqr vs iqr day p respect moreov durat delirium signific posit moder correl time start sit bed wheelchair use spearman r p spearman r p respect result studi suggest earli mobil sit bed wheelchair use hospit surgeri may shorten durat delirium sampl size pilot studi small care interpret need research warrant
|
D003693
|
T048
|
36,343,082
|
characterist prostat biopsi patient dutasterid treatment perform retrospect studi clarifi characterist prostat biopsi patient treat dutasterid benign prostat hyperplasia treatment drug inhibit reductas studi digit clinic data patient includ case treat dutasterid suspect local prostat cancer patient underw transrect ultrasonographi guid prostat biopsi depart propens score match analysi perform base prostat specif antigen psa calcul doubl psa valu dutasterid group age nineti six patient dutasterid control group assess characterist compar characterist patient dutasterid control group well balanc match fewer prostat cancer posit patient dutasterid group compar prostat cancer posit patient group signific case high grade cancer abnorm magnet reson imag mri find dutasterid group dutasterid group abnorm mri find advanc age signific predictor high grade cancer studi show characterist prostat biopsi patient treat dutasterid indic patient dutasterid advanc age abnorm mri find undergo prostat biopsi
|
D011467;D011471
|
T023;T191
|
36,343,081
|
evalu depress anxieti stress status parent patient congenit clubfoot treat ponseti method prospect studi congenit diseas report increas incid depress anxieti stress among parent studi aim investig depress anxieti stress status parent patient congenit clubfoot treatment ponseti method total patient diagnos congenit clubfoot clinic treat ponseti method includ studi depress anxieti stress scale dass use evalu depress anxieti stress status parent treatment consid follow paramet investig effect parent educ level parent econom status famili gender birth order child famili time diagnosi prenat postnat mean dass subdomain score treatment signific lower treatment p moreov signific differ pre posttreat mean dass depress score particip term educ level p pre posttreat dass depress score particip educ level primari school lower particip educ level secondari high school parent may less concern process fulli inform orthoped surgeon treatment protocol near perfect result ponseti method well counsel healthcar profession
|
D003025
|
T019
|
36,343,080
|
transient asystol balloon dilat eustachian tube case report neural mediat reflex induc cardiac arrest head neck surgeri mechan includ direct vagal stimul trigeminocardiac reflex baroreceptor reflex balloon dilat eustachian tube bdet safe procedur without serious complic includ cardiac arrest
|
D005064;D006323;D004427
|
T023;T046;T047
|
36,343,079
|
effect earli progress mobil intens care unit acquir weak mechan ventil patient observ studi earli progress mobil usual consid effect method intens care unit acquir weak icu aw controversi topic remain debat especi initi time safeti profil implement detail studi perform solv disput set critic ill patient underw mechan ventil intens care unit icu hospit march septemb includ studi object patient receiv earli progress mobil includ intervent group n anoth patient match intervent group gender age apach ii score patient receiv routin intervent includ control group n index involv muscl strength barthel index function independ incid rate icu aw complic compar analyz group medic research council score barthel index score intervent group signific higher control group p percentag patient abl complet take shower wear cloth eat groom move bed chair use toilet alon intervent group signific higher control group vs vs vs vs vs vs respect p incid rate icu aw overal incid rate complic intervent group signific lower control group vs vs p earli progress mobil effect increas muscl strength daili basic motion abil improv function status decreas risk icu aw critic ill patient underw mechan ventil attract applic valu clinic
|
D012121;D016638
|
T061;T047
|
36,343,078
|
effect glomerular filtrat rate patient undergo percutan coronari intervent systemat review meta analysi meta analysi relationship glomerular filtrat rate major advers cardiovascular event mace percutan coronari intervent pci studi impact glomerular filtrat rate prognosi pci
|
D062645;D051436;D009203
|
T061;T047
|
36,343,077
|
compar similar differ mesh term associ spine specif journal use forest plot bibliometr analysi common concern literatur comparison similar differ research journal well type research publish present clear methodolog appli given articl interest author use effect effici method locat journal similar field benefit great use forest plot major medic subject head mesh term spine phila pa compar spine j studi display relat similar journal target journal onlin identifi effect similar odd ratio spine phila pa compar spine j
|
D046650;D010506
|
T170;T073
|
36,343,076
|
arthroscop surgeri techniqu snap poplit tendon syndrom case report literatur review incid snap popliteus tendon syndrom type later knee snap high make accur diagnosi difficult proper treatment follow accur diagnosi essenti improv case report treatment
|
D001182;D013710
|
T060;T023;T061
|
36,343,075
|
serum pro oxidantantioxid balanc term versus preterm neonat oxidantantioxid status balanc process begin birth prematur infant particular suscept oxid stress accord mechan oxid stress lack studi field prospect studi aim compar level serum pro oxidantantioxid balanc pab preterm versus term babi prospect cross section studi perform ghaem hospit univers tertiari hospit mashhad iran studi popul includ term preterm neonat admit hospit within birth time studi neonat includ one hundr nineti eight neonat preterm other term signific differ pab level term preterm neonat serum pab level signific lower preterm neonat rather term neonat vs p also signific negat correl pab level gestat age accord previous investig show first time studi pab lower preterm newborn rather term one
|
D000975;D007234
|
T123;T121;T033;T100;T039;T044
|
36,343,074
|
ovarian remnant syndrom paraintestin ovarian serous cystadenofibroma aros year bilater salpingo oophorectomi case report ovarian cystadenofibroma relat rare benign ovarian tumor ovarian remnant syndrom or rare complic bilater salpingo oophorectomi bso report rare case or paraintestin ovarian serous cystadenofibroma develop year total abdomin hysterectomi bso year old woman
|
D062625;D010051
|
T191
|
36,343,073
|
rapid correct sever hyponatremia control subsequ overcorrect oper hysteroscopi intravascular absorpt syndrom case report oper hysteroscopi intravascular absorpt syndrom ohia result system absorpt hypoton solut hysteroscopi may induc sever hyponatremia within hour depend serum sodium na level life threaten requir prompt care remedi treatment
|
D007010;D007889
|
T047;T191
|
36,343,072
|
clear cell sarcoma soft tissu plasmacytoid morpholog rare case report clear cell sarcoma soft tissu ccsst rare malign tumor occur extrem young adult ccsst document atyp histopatholog featur epidermotrop myxoid differenti may set pitfal differenti diagnosi report case ccsst plasmacytoid morpholog never describ
|
D018227;D012983
|
T191
|
36,343,071
|
preval risk factor associ poor sleep among firefight taiwan observ studi sleep qualiti direct correl overal health qualiti life firefight higher workload injuri rate occup studi investig preval risk factor poor sleep qualiti among firefight taiwan cross section studi conduct novemb august sociodemograph inform studi particip collect use structur self administ questionnair chines version pittsburgh sleep qualiti index psqi use evalu subject sleep quantiti qualiti firefight previous month test continu variabl test categor variabl perform univari analysi logist regress analysi conduct multivari analysi eight hundr eighti nine firefight complet questionnair studi period respons rate among report poor sleep qualiti logist regress analysi show femal sex longer work durat year firefight call shift work leisur time physic activ ltpa signific correl increas risk poor sleep qualiti advanc analysi partak ltpa reveal high intens ltpa signific associ higher rate poor sleep qualiti contrast adequ rest ltpa correl lower rate poor sleep qualiti firefight higher risk poor sleep qualiti emphasi place firefight regular ltpa particular experienc sleep problem
|
D061388;D007319
|
T090;T047;T184;T048
|
36,343,070
|
pregnanc complic aortic dissect two case report studi aim investig characterist pregnanc complic aortic dissect ad diagnosi treatment plan matern infant outcom
|
D000784;D011249;D006973;D017545;D019917;D057510
|
T061;T047;T046
|
36,343,069
|
anaesthesia administ ketamin cardiac intervent children common congenit heart diseas safeti efficaci assess differ ketamin dose combin propofol administ anesthesia common pediatr congenit heart diseas chd patient undergo cardiac intervent surgeri provid refer data guidanc use clinic set
|
D015742;D007649;D000758;D006330
|
T061;T121;T019;T109
|
36,343,068
|
compar studi transcutan electr nerv stimul puls electromagnet field therapi manag post herpet neuralgia sciatic nerv compar efficaci puls electromagnet field therapi pemft versus transcutan electr nerv stimul ten treatment post herpet neuralgia sciatic nerv
|
D004561;D051474
|
T061;T047
|
36,343,067
|
comparison bispectr index phase lag entropi general anesthesia sevofluran propofol anesthesia phase lag entropi ple base function connect differ region brain may superior convent depth anesthesia doa method monitor chang conscious howev studi compar ple bispectr index bis method monitor conscious clinic anesthesia total intraven anesthesia tiva anesthesia via inhal therefor evalu differ ple bis method clinic anesthesia includ tiva use propofol anesthesia sevofluran
|
D015742
|
T121;T109
|
36,343,066
|
inherit antithrombin defici caus mutat serpinc gene case report inherit antithrombin defici atd major caus thrombot defici genet test great valu diagnosi hereditari thrombophilia herein report case inherit atd admit hospit includ result genealog discuss signific genet test high risk group hereditari thrombophilia
|
D020152;D019851;D013927
|
T047;T046
|
36,343,065
|
singl cours lusutrombopag multipl invas procedur cirrhosi associ thrombocytopenia case seri lusutrombopag thrombopoietin receptor agonist reduc need platelet transfus plan invas procedur post hoc analysi data registr trial observ lusutrombopag treat patient achiev platelet count l respond patient median day effect platelet count last near week total sinc patient cirrhosi often requir repeat invas procedur kind respons time trend shed light possibl place one invas procedur within singl cours lusutrombopag treatment
|
D013921
|
T047
|
36,343,064
|
prognost studi acut chronic liver failur patient use fibrosi index acut chronic liver failur aclf syndrom character acut deterior liver function cirrhot patient sinc treatment condit difficult prevent paramount import predictor aclf yet identifi determin prognosi cirrhot aclf patient conduct retrospect studi analyz paramet aclf patient cirrhot patient serum total bilirubin level mgdl prothrombin time pt valu acut insult diagnos aclf wherea patient met one criteria diagnos extend type aclf ex aclf overal studi aclf ex aclf patient retrospect investig data analyz acut insult analysi acut insult renal coagul function show signific differ aclf ex aclf group furthermor mortal rate aclf group higher ex aclf group analysi acut insult aspart aminotransferas ast fibrosi fib index score ast platelet ratio index apri show signific differ two group among fib index score correl best aclf sever identifi cirrhot patient poor prognosi fib index use predictor aclf sever care manag cirrhot patient high fib index score consid benefici prevent aclf occurr
|
D065290
|
T047
|
36,343,063
|
diagnost perform mono exponenti dwi versus diffus kurtosi imag breast lesion meta analysi meta analysi aim explor diagnost valu diffus kurtosi imag dki compar mono exponenti diffus weight imag dwi diagnosi breast cancer
|
D007802;D001943
|
T171;T191
|
36,343,062
|
fractur neck talus isol talonavicular disloc case report talar neck fractur injuri frequent result advers outcom impair function activ four group identifi accord hawkin classif canal modif present femal patient fractur neck talus associ talonavicular disloc intact tibiotalar subtalar joint injuri pattern fulfil criteria describ hawkin classif
|
D013628;D050723;D004204;D016103;D019838
|
T023;T037
|
36,343,061
|
develop convolut neural network model diagnos tear anterior cruciat ligament use one knee magnet reson imag deep learn advanc machin learn approach use divers area imag analysi bioinformat natur languag process current studi use one knee magnet reson imag patient attempt develop convolut neural network cnn diagnos anterior cruciat ligament acl tear retrospect recruit patient knee injuri underw knee magnet reson imag evalu patient patient acl torn patient partial tear patient complet tear wherea patient acl intact use cnn algorithm includ subject assign random train set remain assign test set measur model perform area curv ci classif intact tear acl demonstr cnn model train use one knee magnet reson imag patient could help diagnos acl tear
|
D000070598;D022125
|
T037
|
36,343,060
|
nomogram individu predict lower extrem deep venous thrombosi stroke patient retrospect studi develop valid nomogram individu predict lower extrem deep venous thrombosi dvt stroke patient base extrem function daili live abil stroke patient studi stroke patient admit rehabilit medic center first affili hospit nanj medic univers decemb februari taken subject divid dvt group dvt group base exist dvt inter group comparison baselin data perform way analysi varianc kruskal walli rank sum test pearson chi squar test data dimens predict variabl select least absolut shrinkag select oper lasso predict model develop nomogram prepar binari logist regress analysi perform nomogram identifi area receiv oper characterist curv auc harrel concord index calibr curv clinic effect model analyz clinic decis curv analysi age brunnstrom stage lower extrem dimer determin independ predictor affect dvt independ predictor mention develop present nomogram auc concord index confid interv ci indic satisfactori discrimin abil nomogram p valu result hosmer lemeshow test indic good fit predict model decis curv analysi show clinic net benefit model develop nomogram predict lower extrem deep venous thrombosi stroke patient result show nomogram satisfactori predict perform clinic efficaci
|
D020521;D020246
|
T047;T046
|
36,343,059
|
gender differ pulmonari function physic activ qualiti life patient copd base data korea nation health nutrit examin survey perspect pulmonari rehabilit preval chronic obstruct pulmonari diseas copd increas worldwid fourth highest mortal rate studi aim analyz pulmonari function physic activ qualiti life qol gender perspect pulmonari rehabilit korean patient copd studi investig raw data korea nation health nutrit examin survey includ copd patient men year women particip pulmonari function forc vital capac fvc forc expiratori volum second fev frequenc physic activ eg physic activ work leisur strengthen exercis sit time day qol use eq l compar gender patient copd smoke status differ health relat characterist gender p pulmonari function fvc men women p fev men women p fev men women p peak expiratori flow men women p higher men howev predict fev men women p predict fevfvc ratio men women p women frequenc strengthen exercis higher men p qol patient copd signific differ gender provid correct intervent pulmonari rehabilit patient copd gender differ includ physiolog psycholog differ must consid
|
D011788;D029424
|
T078;T047
|
36,343,058
|
laparoscop tripl ureter ureteroureterostomi patient ureter triplic case report ureter triplic ut rare disord challeng diagnosi vari therapeut method past treatment usual involv heminephrureterectomi stunt moieti report case complet ut treat laparoscop tripl ureter ureteroureterostomi uu
|
D014718;D014513;D014517;D006869;D010535;D014549;D005767
|
T061;T060;T023;T047;T046
|
36,343,057
|
forebod lncrna marker low grade glioma depend metabol present systemat studi signatur long chain noncod rnas lncrnas involv metabol fulli predict prognosi patient low grade glioma lggs therefor consist metabol relat lncrna signatur need establish cancer genom atlas tcga use identifi express profil lncrnas contain lggs sampl lncrnas gene relat metabol use establish network form coexpress screen lncrnas relat metabol lncrna clear describ univari cox regress moreov lncrna signatur explor multivari cox regress lasso regress risk score establish accord signatur unattach prognost marker accord cox regress analysi function enrich lncrnas shown employ gene ontolog go kyoto encyclopedia gene genom kegg univari cox retrospect analysi show metabol relat lncrnas independ prognost factor lgg multivari cox regress analysi confirm metabol relat lncrnas prognost gene lgg risk model low risk group higher overal surviv os high risk group p univari cox regress analysi risk score clinic factor show risk score independ prognost factor p hr ci multivari cox result show risk score could predict prognosi lgg p hr ci roc curv analysi show risk score could predict prognosi lgg area year year year go kegg analysi show metabol relat lncrnas main concentr pathway relat tumor metabol order find stabl reliabl target treatment lgg establish metabol relat lncrnas prognost model determin predict prognosi lgg patient provid new solut approach poor prognosi patient lgg may revers trend lgg transform high grade glioma
|
D062085;D005910
|
T123;T191;T114
|
36,343,056
|
bridg gap knowledg skill diagnosi treatment pain neuropathi develop evalu pain educ project clinician primari care set import pain educ wide accept recogn key part educ undergradu postgradu healthcar workforc essenti strategi promot effect pain practic studi aim evalu pain manag modul train cours newli graduat doctor address knowledg gap specialist care primari care physician observ studi evalu pain educ project focus neuropath pain manag core compet provid multimod teach approach didact teach vignett case discuss video teach learn modul pretest survey carri assess baselin knowledg particip complet post test particip experi questionnair collect comparison pre post test score particip undertaken use wilcoxon sign rank test effect size calcul particip experi questionnair score analyz descript produc mean standard deviat question total particip complet cours section averag elig particip particip half femal half particip general practition follow neurologist session wilcoxon sign rank test outlin differ pre post test score signific p mark improv post test evidenc statist signific increas mean score differ develop educ train cours physician address limit exist medic undergradu train neuropath pain manag train led improv particip knowledg skill posit outcom
|
D007858;D009437
|
T061;T184;T062;T047;T041
|
36,343,055
|
compar accuraci shear wave elastographi strain elastographi diagnosi breast tumor systemat review meta analysi shear wave elastographi swe strain elastographi se new ultrason technolog develop rapid recent year elastographi transform elast inform tissu optic inform display thus intuit display tissu elast conflict result obtain differ scholar studi accuraci comparison elastographi technolog diagnosi breast tumor meta analysi aim compar accuraci elastographi technolog diagnosi breast tumor provid refer clinic decis make
|
D054459;D001943
|
T060;T191
|
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