PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,265,703 | molecular mechan studi effect nonion surfact differ degre ethoxyl wettabl anthracit serious risk product safeti coal mine coal dust wettabl coal may success chang ad surfact water howev creation effect dust suppress constrain lack knowledg microscop interact mechan coal dust surfact investig explain macroscop experiment phenomena molecular perspect lauryl polyoxyethylen ether c eo n n select macromolecular model anthracit differ compon construct surfac tension experi hydrophil lipophil balanc hlb calcul show abil surfac hydrophilic follow order c eo c eo c eo contact angl experi xps ftir experi prove surfact adsorb surfac anthracit content carbon element decreas content oxygen element increas indic enhanc surfac hydrophil simul result show degre ethoxyl increas adsorpt strength surfact becom stronger hydrophil head group surfact anthracit surfac uniform distribut greater degre ethoxyl power modifi coal surfac bind water molecul | D003031;D013501 | T120;T121;T109;T122;T167 |
36,265,701 | model ph chang alkalin lake water transfer neutral river water transfer river alkalin lake propos solv lake water level drawdown ecolog degrad problem effect achiev ecolog goal often question sudden ph declin alkalin lake due water transfer consid like harm lake ecolog howev remain unclear extent water transfer affect alkalin lake ph thus three dimension numer model coupl ph calcul method consid carbon balanc mike hydrodynam model develop predict ph chang alkalin lake laboratori field measur verifi model reliabl model accur simul mix water ph water transfer root mean squar error coeffici determin model appli predict ph respons water transfer lake chenghai result show ph respons water transfer demonstr spatial tempor variabl low ph diffus zone ph form northern part lake annual water transfer effect water transfer ph lake cumul time averag ph lake chenghai five year decreas unit strong wind low inflow could effect reduc low ph diffus area daili thermal stratif plateau region threaten low ph diffus area control lake chenghai result provid new refer formul ecolog water transfer strategi alkalin lake similar water bodi | D060106;D045483 | T083;T070 |
36,265,700 | effect chronic exposur natur weather microplast oxid stress level behaviour mitochondri function adult zebrafish danio rerio microplast mps big grow environment concern studi show subleth acut biolog impact typic aquat organ howev littl known biolog effect natur weather mps particular focus mitochondria dysfunct key trigger biolog effect therefor studi natur weather mps produc day day life product character chronic expos day adult zebrafish concentr mgl locomot uncondit anxieti like behaviour assess mitochondri respir membran potenti mitochondri complex activ oxid relat paramet evalu brain liver result reveal weather mps copolym propylen ethylen induc anxieti like behaviour increas brain catalas activ brain lactat dehydrogenas activ inhibit exposur mgl brain glutathion level increas ratio affect mitochondri respiratori chain complex iv also signific decreas brain although compromis mitochondri function hand exposur mgl caus defici liver mitochondri respir decreas mitochondri membran potenti associ mitochondri respiratori chain inhibit increas hepat superoxid dismutas catalas activ notic support occurr ros induc ros releas potenti trigger mitochondri dysfunct overal find highlight potenti indirect cumul environment effect particl may pose aquat ecosystem | D000080545;D014874 | T131;T122 |
36,265,699 | recent progress electrospun nanofibr polym membran water air purif review develop new polym membran excel thermal mechan chemic stabil shown great potenti various environment remedi applic wastewat treatment air filtrat polym membran wide investig past year util overcom sever ecolog issu membran base technolog play critic role water purif air filtrat abil act effici sustain electrospun nanofib membran display excel perform remov various contamin water bacteria dye heavi metal oil nanofibr membran shown good potenti filter air tini particl volatil organ compound toxic gase perform polym membran enhanc fine tune polym structur vari surfac properti strengthen overal membran poros review discuss involv electrospun nanofibr membran differ environment remedi applic review recent progress polym membran develop util nanoparticl natur occur polym | D057139;D019216;D018508 | T196;T052;T073;T057 |
36,265,691 | fluoresc dequench assay activ tev proteas tobacco etch virus tev proteas wide use proteas fusion tag cleavag despit widespread usag assay quick easili quantifi activ laboratori set still lack thus research may encount ineffici cleavag desir fusion protein due poor activ given tev proteas prepar describ develop implement fluoresc dequench base assay quantifi tev proteas activ assess kinet paramet peptid substrat use assay consist c termin tamra fluorophor n termin fluorescein fluorophor canon tev proteas recognit sequenc assay base reduct fluoresc quench fluorescein upon cleavag tev proteas substrat peptid studi spectroscop assess feasibl propos plausibl mechan assay assay optim appli obtain rapid assess tev proteas activ purifi sampl crude lysat extract kinet data obtain improv tev proteas variant compar tradit sds page assay final assay appli determin optimum ph tev proteas studi found assay rapid simpl approach quantifi tev proteas activ find assay crude lysat extract activ assay tev proteas variant assess optimum ph tev proteas reaction demonstr robust util assay | D010450;D010447 | T121;T126;T116 |
36,265,690 | novel ratiometr electrochem aptasensor high sensit detect carcinoembryon antigen novel ratiometr electrochem aptasensor propos carcinoembryon antigen cea detect base exonucleas iii exo iii assist recycl roll circl amplif rca strategi thiolat ferrocen label hairpin probe fc hp fix gold nanoparticl aunp modifi gold electrod aue surfac au bond presenc cea led releas trigger hybrid protrud hairpin probe hp trigger exo iii cleavag reaction accompani releas trigger generat new dna fragment use success hybrid fc hp exo iii cleavag process remain fc hp fragment hybrid primer rca templat initi rca process long singl strand polynucleotid produc methylen blue mb bind chang result signal fc fc decreas mb mb increas achiev linear relationship mb fc logarithm cea concentr rang pg ml ng ml detect limit pg ml addit develop aptasensor success appli detect cea human serum sampl therefor propos strategi might provid new platform clinic detect cea | D015374;D053768;D052157 | T059;T073;T075;T114 |
36,265,689 | epifluoresc singl molecul count streptavidin phycoerythrin conjug singl molecul method specif singl molecul count convey high sensit research applic howev singl molecul count experi requir special equip consum perform demonstr util use bright streptavidin phycoerythrin sa pe conjug epifluoresc microscop singl molecul count applic work show visual singl molecul glass surfac perform singl molecul diagnost assay magnet microparticl imag individu foci cell surfac approach simpl effect research interest singl molecul count | D010799;D036103 | T090;T123;T116 |
36,265,687 | shoc control erk driven neural crest develop balanc compon extracellular matrix extracellular signal regul kinas erk pathway essenti embryon develop scaffold protein shoc critic modul erk signal mutat shoc gene lead human development diseas known noonan like syndrom loos anagen hair nslh loss shoc shoc nslh caus mutat affect tissu neural crest nc origin studi util zebrafish model dissect role shoc erk signal develop nc studi establish loss shoc signific alter express transcript factor regul specif differenti nc cell use compar transcriptom analysi nc deriv cell shoc crisprca mutant larva found shoc mediat signal regul gene program sever level includ express gene code protein extracellular matrix ecm ecm regul togeth result demonstr shoc essenti regul nc develop studi also indic disbal turnov ecm may lead abnorm found nslh patient | D009634 | T019;T047 |
36,265,674 | network experiment pharmacolog mechan si wu tang improv ovarian function mous model prematur ovarian failur induc cyclophosphamid si wu tang swt becom common basic prescript supplement blood regul menstruat enjoy reput first prescript gynecolog often report treatment prematur ovarian failur pof howev knowledg specif mechan still limit | D016649;D008594 | T047 |
36,265,651 | selenium selenoprotein thermogen adipocyt selenium se involv energi metabol liver white adipos tissu skelet muscl may also play role thermogen adipocyt ie brown beig adipocyt therebi micronutri key nutrit target aid combat obes metabol diseas thermogen adipocyt particular brown adipos tissu bat selenoprotein type iodothyronin deiodinas dio essenti activ adapt thermogenesi recent evid suggest addit selenoprotein may also particip process role se metabol pathway also envis review discuss recogn effect knowledg gap involv se metabol selenoprotein mechan adapt thermogenesi thermogen brown beig adipocyt | D012643 | T123;T196;T121 |
36,265,650 | explor effect tether domain fold grb protein two third eukaryot protein evolv multidomain construct vivo domain fold within polypeptid chain inter domain interact possibl crucial correct fold howev date experiment fold studi base domain isol effort better understand multidomain fold work analyz equilibrium kinet fold experi fold properti growth factor receptor bound protein grb compos one src homolog domain flank two src homolog domain particular compar kinet featur multidomain construct domain express isol perform singl doubl mix fold experi demonstr fold sh domain kinet trap misfold intermedi tether c sh import within multidomain construct misfold occur independ refold start c sh unfold nativ state interest data report peculiar scenario sh c sh domain reciproc transient interact fold altogeth analysi kinet fold data provid quantit descript multidomain fold grb protein discuss light previous work multidomain fold | D018909;D010455 | T087;T121;T116 |
36,265,649 | yf mutant salmonella ornithin lysin decarboxylas alter stereospecif putrescin alloster activ site tyrosin ornithin lysin decarboxylas dokdc locat activ site suggest respons stereospecif enzym prepar yf mutant form salmonella enterica serovar typhimurium dokdc evalu catalyt activ l lysin ornithin kinet result show yf mutant measur decarboxylas activ l lysin ornithin wild type dokdc spectroscop experi show amino acid bind form extern aldimin complex pyridox phosphat max nm addit obtain crystal structur yf dokdc bound hepe putrescin ornithin lysin arginin amino acid bind crystal form equilibrium mixtur gem diamin extern aldimin complex furthermor crystal structur reveal unexpect alloster product activ site putrescin locat fold axi two activ site putrescin bind donat hydrogen bond ammonium group asp gln specif helix chain addit mm putrescin elimin lag steadi state kinet abolish sigmoid kinet catalyt loop model alphafold model show glu form addit hydrogen bond bound putrescin like stabil catalyt close conform | D009952;D002262 | T123;T121;T126;T116 |
36,265,611 | molecular mechan therapeut signific dihydromyricetin nonalcohol fatti liver diseas preval nonalcohol fatti liver diseas nafld steadili increas becom one preval chronic liver diseas worldwid recent studi shown dihydromyricetin dhm influenti treat nafld purpos review describ dhm prevent treat nafld potenti mechan depth summari preclin vitro vivo studi brief overview dhm potenti role nafld involv regul lipidglucos metabol possibl via anti inflammatori sirtuin depend mechan nafld current effect approv medic therapi dhm characterist liver protect antioxid anti inflammatori apoptosi regulatori benefit provid new idea treatment nafld increas interest util natur product prevent control liver diseas work aim provid new idea treatment nafld acceler translat bench bedsid | D065626 | T047 |
36,265,610 | implic abc transport non prolif diseas abc transport play essenti role develop multidrug resist thus interest context anticanc therapi howev mdr bcrp mrp involv number key process maintain viabil bodi whole well individu organ cell transport support protect properti anatom histohemat barrier determin entri toxin drug organ tissu well facilit elimin review discuss main area use modul abc export activ may relev due either initi imbal activ need temporari chang efflux rate therapeut purpos control modul activ abc famili efflux transport open broad prospect treatment various diseas associ univers difficulti deliveri drug transport substrat characterist individu patient caus singl nucleotid polymorph activ inhibitor transport find applic | D018528;D019008 | T123;T116;T038;T042 |
36,265,555 | hypertens heart diseas myocardi fibrosi tradit chines medicin help address unmet therapeut need long term elev blood pressur increas cardiac load lead myocardi fibrosi mf varieti patholog mechan signal transduct pathway involv process hypertens mf great signific occurr develop ventricular dilat heart failur mf patholog basi hypertens heart diseas hhd blood pressur control key delay mf reduc occurr cardiovascular event although larg number experiment result suggest anti mf drug therapi made great progress conclus relev clinic trial still optimist urgent find new effect anti mf medicin clinic efficaci tradit chines medicin tcm treatment mf hhd obvious achiev made mechan research studi confirm varieti tcm compound prescript natur compound play differ degre inhibitori effect mf studi review pathogenesi mf hhd current drug treatment strategi summar latest research progress tcm treatment mf hhd demonstr mechan cardiac protect effect final point limit current studi prospect futur research tcm | D009202;D006973;D006333;D004365 | T121;T123;T047;T046 |
36,265,554 | ikk increas neuropilin promot inhibitori function cd breg control allerg diseas regulatori b cell breg potent suppress immun disord includ allerg contact hypersensit chs ikk overactiv promin various inflammatori diseas howev effect breg defin studi investig new regul inhibitori mechan breg ikkca transgen mice cys mutat result increas ikk activ employ analysi il compet cd breg expand ikkca mice b cell specif ikkca mutat mice ikkca mutant cd breg stronger suppress effect cd cd cell vitro chs respons vivo inhibitori cd breg ikkca mice character upregul neuropilin nrp il comparison ikkwt mice interest increas express nrp observ cd breg compar cd b cell wild type mice suppress activ wild type cd breg vitro attenu inhibit nrp breg silenc ligand semaf cd cell find delin distinct role ikk activ enhanc breg disturb immun balanc identifi nrp novel regulatori molecul breg part contribut b cell mediat immun toler | D060151;D007154 | T047;T025 |
36,265,550 | subcellular interactom reveal merg apex cross link mass spectrometri subcellular protein protein interact ppis essenti understand mechan divers cellular signal event pathogenesi diseas herein report integr apex proxim label chemic cross link coupl mass spectrometri cxms platform name apex cxms spatial resolv subcellular interactom profil high throughput manner apex proxim label rapid captur subcellular proteom high reactiv chemic cross linker captur weak dynam interact global without extra genet manipul apex cxms first appli mitochondria identifi pair interprotein cross link six pair new interact select verifi coimmunoprecipit mammalian two hybrid system surfac plasmon reson method besid approach appli nucleus captur pair interprotein cross link approxim nuclear specif apex cxms thus provid simpl fast general altern map divers subcellular ppis | D011506;D008322 | T123;T015;T116 |
36,265,544 | facil prepar three dimension wafer interconnect porous structur high perform captur nondestruct releas circul tumor cell effici isol downstream bioinform analysi circul tumor cell ctcs whole blood contribut earli diagnosi cancer investig cancer metastasi howev separ releas ctcs remain great challeng due extrem rariti ctcs sever interfer cell complex clinic sampl herein develop low cost easi fabric aptam function wafer three dimension interconnect porous structur graft polydopamin pda poli ethylen glycol peg aptam sequenc ni pda peg apt captur releas ctcs ni pda peg apt wafer integr featur ni foam interconnect porous structur offer enough tunnel cell flow enhanc aptam cell contact frequenc spacer peg flexibl high hydrophil properti increas anti interfer abil provid wafer bind site aptam result enhanc captur specif effici ctcs advantag ni pda peg apt wafer achiev high captur effici captur cancer cell mild releas endonucleas effici good prolifer furthermor tumor cell inject mice experienc circul vivo blood sampl circul target tumor cell effici captur wafer follow releas recultur cell high viabil downstream metabolom analysi show target cancer cell remain high biolog activ well separ mcf cell base metabol profil pca analysi indic great potenti strategi research progress cancer metastasi notabl wafer cheap cost us dollar easili prepar environment friend reagent also process captur releas tumor cell complet within hour benefici larg scale clinic use futur | D009360 | T191;T025 |
36,265,525 | rna seq approach investig effect melatonin bone marrow deriv dendrit cell dextran sodium sulfat induc coliti mice melatonin mlt report therapeut effect inflammatori bowel diseas ibd ulcer coliti uc crohn diseas cd due anti inflammatori immunomodulatori properti howev whether benefici effect melatonin coliti alter immun respons bone marrow deriv dendrit cell bmdcs well character propos mlt allevi dextran sulfat sodium dss induc coliti mice regul immun respons bmdcs lncrna circrna mirna mrna may involv first establish dss induc coliti mous model found concentr mlt serum dss induc coliti mice signific lower control mice supplement mlt allevi dss induc coliti mice reflect prevent mous bodi weight loss colon length shorten inflamm epitheli tissu destruct absciss colon isol cultur bmdcs found mlt could inhibit activ bmdcs coliti mice reflect reduc phagocytot abil cell inhibit migrat decreas secret pro inflammatori cytokin rna sequenc result show mlt promot transform bmdcs immun toler phenotyp dss induc coliti mice affect non code rnas ncrnas among lncrna ensmust circrna circrna predict interact mirna mrnas ywhaz ccl target mirna involv mlt induc alter bmdcs function dss induc coliti mice via pik akt pathway find may provid clue understand mlt inhibit inflammatori respons dss induc coliti may alter bmdcs function | D008550;D062085;D003092;D035683 | T121;T123;T109;T114;T125;T047 |
36,265,504 | continu enzalutamid progress metastat castrat resist prostat cancer treat docetaxel presid intern randomis phase b studi although androgen depriv therapi typic given long term men metastat prostat cancer second generat hormon therapi general discontinu subsequ line treatment aim evalu efficaci continu enzalutamid progress control metastat castrat resist prostat cancer mcrpc treat docetaxel prednisolon | D000971;D064129 | T061;T191 |
36,265,503 | associ interact mosaic chromosom alter polygen risk score risk lung cancer array base case control associ prospect cohort studi mosaic chromosom alter mcas detect blood deriv dna larg structur alter clonal haematopoiet origin associ various diseas haematolog malign infect solid cancer aim investig whether mcas contribut risk lung cancer modifi effect polygen risk score prs lung cancer risk predict | D041322;D008175 | T026;T191 |
36,265,502 | pembrolizumab versus placebo adjuv therapi resect stage iib iic melanoma keynot distant metastasi free surviv result multicentr doubl blind randomis phase trial patient stage iib iic melanoma undergo surgeri alon substanti risk diseas recurr adjuv pembrolizumab signific improv recurr free surviv versus placebo stage iib iic melanoma first interim analysi keynot trial report result secondari endpoint distant metastasi free surviv prespecifi third interim analysi recurr free surviv longer follow | D008545;D012878;D013736 | T191 |
36,265,493 | glioblastoma stem cell specif histamin secret drive pro angiogen tumor microenviron remodel communic glioblastoma stem cell gscs surround microenviron promin featur account aggress biolog glioblastoma multiform gbm howev mechan gscs proactiv drive interact microenviron well understood studi interrog metabolit preferenti secret gscs found gscs produc secret histamin shape pro angiogen tumor microenviron histamin produc abil attribut hkme modif activ histidin decarboxylas hdc transcript via myc notabl hdc high express gbm associ poor surviv patient gsc secret histamin activ endotheli cell trigger histamin h receptor h r ca nf b axi therebi promot angiogenesi gbm progress import pharmacolog blockag h r use antihistamin imped growth gbm xenograft mice find establish gsc specif metabolit secret remodel tumor microenviron highlight histamin target potenti strategi gbm therapi | D005909;D001932 | T191 |
36,265,488 | radap regul alt hdr chromatin direct homeostasi terra altern lengthen telomer alt homolog direct repair hdr mechan telomer elong control prolifer subset aggress cancer recent studi reveal telomer repeat contain rna terra promot alt associ hdr alt hdr report radap crucial alt factor interact terra util generat r loop hr intermedi also show radap bind might stabil terra contain r loop radap deplet reduc r loop format telomer dna break proteom analys uncov role radap mediat terra r loop homeostasi mechan chromatin direct suppress terra prevent transcript replic collis trcs alt hdr intrigu find terra bind non canon function radap requir intrins sumo sim regulatori axi find provid insight multi contextu function radap within alt mechan regul terra | D059505;D062085 | T045;T123;T114;T043 |
36,265,487 | structur function relationship eukaryot transcript factor role intrins disord region gene regul mani principl bacteri gene regul foundat understand mechan eukaryot transcript howev stark structur function differ exist eukaryot bacteri transcript factor complic infer properti eukaryot system bacteria review differ focus impact intrins disord region thermodynam kinet paramet govern eukaryot transcript factor interact protein chromatin preval unstructur domain eukaryot transcript factor well known impact function call sophist knowledg mechan support use evid avail date posit intrins disord region necessari complex integr function eukaryot transcript factor understand rich biochemistri develop deep molecular understand regulatori mechan | D014157;D064267 | T123;T116 |
36,265,486 | terra radap promot altern lengthen telomer r loop switch altern lengthen telomer alt telomeras independ process maintain telomer mediat break induc replic bir rad promot alt facilit loop format alt also occur rad independ bir pathway show telomer non code rna terra form dynam telomer r loop contribut alt activ rad knockout cell terra form r loop vitro telomer radap depend manner format r loop terra increas g quadruplex gs telomer g stabil enhanc alt even terra deplet suggest gs act downstream r loop promot bir vitro telomer r loop assembl terra radap generat gs persist r loop resolut allow format telomer loop without rad thus dynam telomer r loop form terra radap enabl rad independ alt pathway gs orchestr r loop switch telomer stimul bir | D019098;D062085 | T123;T126;T116;T114 |
36,265,485 | memet algorithm enabl effici local global atom protein protein dock backbon side chain flexibl protein complex format encod specif interact atom scale comput cost model protein level often requir use simplifi energi model limit conform flexibl particular use atom energi function backbon side chain flexibl result rug energi landscap difficult explor studi develop protein protein dock algorithm evodock combin strength differenti evolut algorithm effici explor global search space benefit local optim method refin detail atom interact evodock enabl accur fast local global protein protein dock use atom energi function side chain flexibl comparison standard method built mont carlo optim demonstr improv accuraci increas comput speed time evolutionari algorithm also enabl effici atomist dock backbon flexibl | D000465;D011506 | T123;T170;T116 |
36,265,484 | structur dynam effect paraoxon bind human acetylcholinesteras x ray crystallographi inelast neutron scatter organophosphorus op compound includ nerv agent pesticid coval bind catalyt serin human acetylcholinesteras hach therebi inhibit acetylcholin hydrolysi necessari effici neurotransmiss oxim antidot reactiv op conjug hach reactiv effici low pesticid paraoxon pox understand structur dynam determin op inhibit reactiv provid insight design improv reactiv x ray structur hach unag pox pox oxim mmb rsb mmb report signific conform distort acyl loop observ upon pox bind partial restor nativ conform oxim neutron vibrat spectroscopi combin molecular dynam simul show picosecond vibrat dynam acyl loop soften cm frequenc rang acyl loop structur perturb may correl picosecond vibrat dynam yield comprehens templat structur base reactiv design | D000110;D010575 | T131;T126;T116 |
36,265,482 | liabil scale herit estim biobank studi low preval diseas theori liabil scale model under genet basi complex diseas provid import way interpret compar understand result generat biolog studi particular estim liabil scale herit lsh liabil model facilit understand comparison relat import genet environment risk factor shape differ clinic import diseas outcom increas larg scale biobank studi link genet inform electron health record contain hundr diseas diagnosi indic most occur infrequ within sampl becom avail propos extens exist liabil scale model theori suitabl estim lsh biobank studi low preval diseas simul studi find deriv express yield lower mean squar error mse less sensit preval misspecif compar previous transform diseas popul preval lsh especi biobank sampl preval less wider popul appli express diagnost outcom preval uk biobank studi reveal import differ lsh obtain differ theoret express impact conclus made compar lsh across diseas outcom demonstr import care consider estim predict low preval diseas outcom facilit improv infer under genet basi popul preval diseas especi biobank sampl ascertain result healthier sampl popul | D018070;D055106 | T063;T093 |
36,265,481 | chronic kidney diseas post percutan coronari intervent mortal patient left main equival coronari arteri diseas patient chronic kidney diseas underrepres registri random trial coronari arteri diseas manag investig effect chronic kidney diseas outcom nonemerg percutan coronari intervent patient left main left main equival coronari arteri diseas analyz data new york state percutan coronari intervent registri calendar year involv elect percutan coronari intervent case outcom percutan coronari intervent patient various degre chronic kidney diseas stabl left main left main equival coronari arteri diseas compar | D003324;D062645;D051436 | T061;T047 |
36,265,477 | postur control paradigm biovrsea toward neurophysiolog signatur object defin new neurophysiolog signatur electroencephalographi eeg complex postur control task use biovrsea paradigm consist virtual realiti vr move platform mimick behavior boat sea approach eeg electrod data healthi subject acquir experi compos segment baselin pre post baselin last stand motionless platform mountain view vr goggl pre post last stand motionless platform sea simul task last platform move adapt wave subject hold bar maintain balanc power spectral densiti psd differ task minus baselin comput everi electrod five frequenc band delta theta alpha beta low gamma statist signific comput main result band signific whole cohort task regard baselin delta band show prefront psd increas theta fronto pariet decreas alpha global scalp power decreas beta increas occipit tempor scalp decreas area low gamma signific slight increas pariet occipit tempor scalp area signific studi develop neurophysiolog refer complex postur control task particular found strong local activ associ certain frequenc band certain phase experi first step toward neurophysiolog signatur use identifi patholog condit lack quantit diagnost assess | D004569;D004856 | T060;T040;T034 |
36,265,473 | develop magnetorelaxometri imag human applic objectivemagnet nanoparticl mnps promis tool biomed applic cancer therapi diagnosi local quantif mnp distribut often mandatori obtain magnetorelaxometri imag mrxi approachin work capabl mrxi quantit imag mnp insid larger volum human head investig develop human head phantom simul glioblastoma multiform gbm tumor contain mnp magnet hyperthermia treatment sensit mrxi setup detect mnp concentr rang mg cm studiedmain resultth result show high capabl mrxi detect mnps human head size volum superfici sourc concentr larger mg cm could reconstruct resulot cm significanceth reconstruct mnp distribut mimick gbm tumor cmvolum clinic relev iron concentr demonstr thein vivofeas mrxi human | D006979;D009369;D058185 | T061;T191;T130 |
36,265,472 | biohybrid robot recent progress challeng perspect past ten year seen rapid expans field biohybrid robot combin engin synthet compon live biolog materi new robot solut develop har adapt live muscl sensit live sensori cell even comput abil live neuron biohybrid robot taken popular scientif media storm advanc field move biohybrid robot scienc fiction real scienc engin get field biohybrid robot go next perspect first provid histor context crucial subarea biohybrid robot review past year advanc microorgan bot sperm bot cyborg tissu base robot present critic challeng face field provid perspect vital futur step toward creat autonom live machin | D012371 | T090 |
36,265,470 | sophi viral outbreak investig transmiss histori reconstruct joint phylogenet network theori framework genom epidemiolog wide use viral outbreak investig still methodolog face mani challeng first method account intra host viral divers second maximum parsimoni principl continu employ phylogenet infer transmiss histori even though maximum likelihood bayesian model usual consist third mani method util case specif data sampl time infect exposur interv imped studi persist infect vulner group inform limit use final method implicit assum transmiss event independ although common sourc outbreak violat assumpt propos maximum likelihood framework sophi base integr phylogenet random graph model infer transmiss network viral phylogeni expect properti inter host social network model random graph given expect degre distribut sophi scalabl account intra host divers accur infer transmiss without case specif epidemiolog data | D004196;D023281 | T091;T067 |
36,265,469 | resistor algorithm predict resist mutat via pareto optim multist protein design mutat signatur resist pharmacolog treatment major public health challeng introduc resistor structur sequenc base algorithm prospect predict resist mutat drug design resistor comput pareto frontier four resist caus criteria chang bind affin k drug endogen ligand upon protein mutat probabl mutat occur base empir deriv mutat signatur cardin mutat compris hotspot valid appli resistor egfr braf kinas inhibitor treat lung adenocarcinoma melanoma resistor correct identifi eight clinic signific egfr resist mutat includ erlotinib gefitinib gatekeep tm mutat five known osimertinib resist mutat furthermor resistor predict consist braf inhibitor sensit data retrospect prospect experi use kincon biosensor resistor avail open sourc protein design softwar osprey | D008175;D000970 | T121;T191;T109 |
36,265,468 | quantifi uncertainti assembl free genom wide distanc estim phylogenet relationship use subsampl comput distanc two genom without align even access assembl mani downstream analys howev align free method includ fast grow field genom skim hamper signific methodolog gap accur method mani k mer base assembl free distanc calcul exist measur uncertainti estim distanc suffici studi paper show bootstrap standard non parametr method measur estim uncertainti accur k mer base method reli k mer frequenc profil instead propos use subsampl replac combin correct step reduc varianc infer distribut show distribut distanc use procedur match true uncertainti estim result phylogenet support valu effect differenti correct incorrect branch identifi controversi branch chang across align free align base phylogeni report literatur | D000465;D016678 | T170;T028 |
36,265,467 | immunotyp sr comput approach genotyp immunoglobulin heavi chain variabl gene use short read data human immunoglobulin heavi chain igh locus chromosom includ function copi variabl gene ighv critic structur antibodi identifi neutral pathogen invad part adapt immun system high repetit sequenc composit igh locus particular difficult assembl genotyp use standard short read sequenc technolog introduc immunotyp sr algorithm tool genotyp cnv analysi germlin ighv gene illumina whole genom sequenc wgs data use combinatori optim formul resolv ambigu read map valid immunotyp sr individu whose ighv allel composit independ valid well concord wgs replic nine individu appli immunotyp sr covid patient investig associ ighv allel anti type ifn autoantibodi previous associ covid sever | D007135;D000086382 | T129;T047;T116;T067 |
36,265,466 | ultrafast interpret singl cell genom analysi fast higashi singl cell hi c schi c technolog probe three dimension genom structur individu cell howev exist schi c analysi method hinder data qualiti complex genom pattern lack comput scalabl interpret pose challeng larg scale analysi introduc fast higashi ultrafast interpret method base tensor decomposit partial random walk restart enabl joint identif cell ident chromatin meta interact spars schi c data extens evalu demonstr advantag fast higashi exist method lead improv delin rare cell type continu development trajectori fast higashi direct identifi genom featur defin distinct cell type help elucid cell type specif connect genom structur function moreov fast higashi general incorpor singl cell omic data fast higashi provid high effici interpret schi c analysi solut applic broad rang biolog context | D059010;D016678 | T059;T028 |
36,265,465 | belay model discret continu spatial variat gene express spatial resolv transcriptom spatial resolv transcriptom srt technolog measur gene express known locat tissu slice enabl identif spatial vari gene cell type current approach task assum either gene express vari continu across tissu tissu contain small number region distinct cellular composit propos model srt data layer tissu includ continu discret spatial variat express algorithm belay learn paramet model belay model gene express piecewis linear function relat depth tissu layer possibl discontinu layer boundari use conform map model relat depth deriv dynam program algorithm infer layer boundari gene express function belay accur identifi tissu layer biolog meaning spatial vari gene srt data brain skin | D059467;D000465 | T081;T170;T086 |
36,265,442 | map brain gene coexpress daytim transcriptom unveil diurnal molecular network deciph perturb gene signatur brain tissu transcriptom may organ gene coexpress network under biolog driver remain incomplet understood undertook larg scale transcriptom studi use wild type mous striatal tissu sampl dissect exclus afternoon defin high reproduc gene coexpress modul found modul enrich cell type molecular complex marker respect import modul high enrich daili rhythmic express gene peak trough distinct tempor kinet reveal under biolog striatal diurnal gene network moreov diurnal coexpress network domin featur daytim transcriptom mous cortex next employ striatal coexpress modul deciph striatal transcriptom signatur huntington diseas model heterozyg null mice gene uncov novel function prkcq kdmb oligodendrocyt differenti bipolar disord associ trank regul anxieti like behavior nocturn locomot | D059467;D006816 | T081;T047;T086 |
36,265,441 | locus coeruleus regul memori link core function memori system abil link appropri event issu neuron chowdhuri et al pinpoint specif neuromodulatori circuit contextu memori link format hippocampus | D008125;D006624 | T026;T023 |
36,265,440 | find pleasur repetit behavior issu neuron sun et al identifi neuron subpopul medial paralemnisc nucleus under repetit self groom project dopamin neuron ventral tegment area subpopul also drive reward allevi anxieti | D057181;D017557 | T023;T041 |
36,265,439 | ieg express defin sst neuron ensembl critic motor learn neocort interneuron hypothes import circuit reorgan learn issu neuron yang et al identifi subset npas express somatostatin interneuron help regul excitatori synapt plastic motor learn | D013004;D007395 | T125;T121;T116;T025 |
36,265,438 | target oxid distress treat chemobrain go choroid plexus cerebrospin fluid flow chemobrain variabl debilit consequ lifesav cancer treatment issu neuron jang colleagu provid new conceptu framework base choroid plexus csf antioxid status advanc understand chemobrain nervous system pathobiolog identifi novel therapeut opportun | D002831;D000084202 | T023;T048 |
36,265,437 | line transposon genom integr neurodegener abnorm activ line transpos element associ neurolog diseas issu neuron takahashi et al show l hyperact occur neurodegen syndrom ataxia telangiectasia caus ataxia cerebellar degener mice | D001260;D019636 | T047 |
36,265,428 | impact glycem gap day advers outcom patient acut st segment elev myocardi infarct stress induc hyperglycemia sih general occur critic ill recent glycem gap gap consid superior indic sih howev data associ gap prognosi st segment elev myocardi infarct stemi limit observ studi aim estim prognost valu gap mean defin differ mean blood glucos level mgl within h admiss ac deriv averag glucos adag patient acut stemi | D000072657;D006943;D003920;D062645 | T033;T047;T061 |
36,265,423 | stimul leach metalloid along print fractur rock vados zone fractur rock aquif suscept contamin metal loid rapid migrat poor develop overburden fractur rock vados zone thus groundwat compar typic porous aquif retent effect within rock matrix small rapid advect along fractur lead higher risk groundwat contamin howev high complex anisotrop pathway natur fractur hinder research field construct reproduc fractur studi use print follow comput x ray microtomographi ct scan fractur rock collect natur limeston aquif stimul metalloid releas observ fractur rock column leach leachat concentr arsenic antimoni sb increas time respect compar porous vados zone fluctuat fractur metalloid releas pattern dissolv adsorb phase attribut retent filtrat effect induc soil particl within fractur geophys properti porous overburden especi aggreg characterist great affect non equilibrium leach behavior limit effect near equilibrium leach sb explor modifi surfici soil layer either montmorillonit clay charcoal result studi provid novel method use inform model risk assess fractur rock aquif | D058955;D060587 | T081;T196;T070;T082 |
36,265,422 | detect differ gait initi older adult faller non faller multivari function princip compon analysi gait initi gi import locomotor transit task includ anticipatori postur adjust joint propuls necessari first step walk discret variabl analysi gi faller non faller shown import group differ complex time seri analysi function princip compon analysi fpca may highlight group differ detect use discret comparison alon studi aim character differ faller non faller examin kinemat kinet gait initi use multivari fpca mfpca sampl communiti dwell older adult complet five walk trial gi measur forc platform mfpca center pressur kinemat kinet conduct function princip compon score compar group overal mfpca provid comprehens assess gi support enhanc previous find respect differ faller non faller cohort weight transfer forward progress faller demonstr greater rang mediolater movement lower later forc non faller first step faller gradual rise vertic forc well greater later movement toward edg base support faller also demonstr shorter step length indic alter approach gi mediolater anteroposterior stabil may priorit forward advanc | D005684;D016138 | T033;T056;T169 |
36,265,421 | morpholog function biomechan progress lv remodel porcin model hfpef heart failur hf preserv eject fraction hfpef account half heart failur case progress cardiac biomechan pathogenesi complet understood investig publish porcin model hfpef generat progress constrict aortic cuff caus progress left ventricl lv pressur overload character hypertrophi diastol dysfunct overt hf elev plasma beta natriuret peptid bnp character morpholog function featur perform imag base finit element model multipl time point understand biomechan evolv morpholog function chang pathogenesi provid data futur growth remodel investig result show hypertroph respons quick manifest effect prevent elev systol myocardi stress suggest activ compens remodel consequ hypertrophi diastol myocardi stress decreas despit elev diastol pressur left ventricl hypertrophi lvh myocardium also exhibit quick elev activ tension onset diseas progress signific decreas myocardi strain signific longitudin direct elev myocardi stiff diastol pressur reflect diastol dysfunct also manifest delay onset diseas correl analysi show hypertrophi close correl systol pressur activ tension systol myocardi stress suggest factor may play role initi hypertrophi myocardi stiff weak correl lv pressur myocardi stress | D006333 | T047;T046 |
36,265,418 | vascular anatomi base local intervertebr disc assist needl punctur construct mous model mechan injuri induc lumbar intervertebr disc degener intervertebr disc degener idd may primari caus low back pain potenti therapeut idd must valid anim model effect quantifi use function metric needl punctur intervertebr disc ivd use induc idd mice rat due oper challeng anim idd model construct use needl punctur caudal ivd mice use larger anim rat rabbit howev mous idd model involv lumbar ivd punctur prefer mice genet similar human common use transgen anim human idd common affect lumbar spine construct needl punctur base mous idd model reli vascular anatomi pinpoint lumbar ivd evalu morpholog molecular chang model use radiolog patholog immunostain examin mechan injuri induc idd model lumbar ivd accur local inject color perfus common iliac arteri vein right iliolumbar vein help visual punctur posit avoid neuromuscular injuri shorten oper time decreas bleed nucleus pulposus cell defin krt disc height index gradual decreas surgeri degen effect peak week conclus establish mous idd model perform precis punctur lumbar ivd via ventral anterior approach assist vessel posit model effect simul effect idd may serv effici research tool | D055959;D007403;D000070614 | T047;T023;T190 |
36,265,416 | assess head ct protocol reduc radiat dose eye len select hospit kaduna state nigeria len eye sensit radiat most expos scatter radiat comput tomographi ct procedur studi measur absorb dose len eye propos diagnost refer level head examin compar current research result intern standard incur dose patient undergon head neck ct procedur measur use thermoluminesc dosimet tld protocol adopt studi brain sequenti spiral sinus sequenti spiral neck brain spiral scan paramet ct dose index ctdi dose length product dlp tube current exposur time product mas kilovoltag peak kvp pitch factor patient record patient divid two age group year pediatr year adult patient tld chip place patient skin surfac two differ locat measur absorb dose len eye mean dose standard deviat left right eye len hospit paediatr patient left mgi right mgi adult patient left mgi right mgi hospit b paediatr left mgi right mgi adult left mgi right mgi hospit c paediatr left mgi right mgi adult left mgi right mgi threshold recommend intern commiss radiolog protect icrp len eye damag appear clinic safe ct scan remain crucial tool dose reduct achiev control differ factor affect patient dose | D014057;D007908 | T060;T023 |
36,265,406 | prenat benzo pyren exposur impair hippocamp synapt plastic cognit function sd rat offspr adolesc adulthood via hdac mediat histon deacetyl benzo pyren b p widespread carcinogen pollut environ although previous studi demonstr neurodevelopment toxic b p precis mechan under neurotox effect induc prenat b p exposur remain larg unknown present studi pregnant spragu dawley sd rat inject intraperiton mgkg bw b p three consecut day embryon day learn memori abil offspr determin morri water maze mwm test number dendrit branch densiti dendrit spine hippocamp ca dg region evalu golgi cox stain pnd pnd mrna express bdnf psd syp offspr hippocampus detect qrt pcr protein express bdnf psd syp hdac achk achk measur western blot immunohistochemistri chip pcr perform detect level achk achk promot region bdnf psd gene result show rat prenat expos b p exhibit impair spatial learn memori abil number dendrit branch densiti dendrit spine hippocamp ca dg region signific reduc adolesc adulthood express hdac protein signific upregul achk achk bdnf psd syp protein level signific downregul hippocampus b p expos rat addit chip result show prenat b p exposur mark decreas level achk achk promot region bdnf psd gene hippocampus pnd pnd offspr result suggest prenat b p exposur impair cognit function hippocamp synapt plastic offspr adolesc adulthood hdac mediat histon deacetyl play crucial role deficit | D001564;D011297 | T121;T037;T109 |
36,265,405 | metabolom transcriptom analys reveal sucros synthas regul maiz pollen viabil heat drought stress maiz pollen high sensit heat drought studi investig combin effect heat drought pollen viabil studi pollen structur physiolog characterist determin heat drought combin stressor furthermor integr metabolom transcriptom analys maiz pollen conduct identifi potenti mechan stress respons tassel growth spikelet develop consider suppress pollen viabil negat impact pollen starch granul deplet anthesi stress inhibitori effect signific due combin stress heat drought individu metabol analysi identifi import metabolit combin stress compar treatment includ sugar deriv relat pollen viabil transcriptom also reveal carbohydr metabol signific alter stress moreov comprehens metabolom transcriptom analysi identifi central mechan biosynthesi udp glucos involv reduc activ sucros synthas sh shrunken sus sucros synthas suppress sucros transfer udp glucos lead pollen viabil exhaust stress conclus lower pollen viabil heat drought stress associ poor sucros synthas activ due stress treatment | D055864;D003313 | T168;T070;T002 |
36,265,404 | pyrolysi kinet environment risk oil base drill cut china largest shale gas exploit site chongq fule shale gas field largest shale gas explor site china produc larg amount oil base drill cut obdc everi year hazard wast tradit treatment method solidificationstabil recycl valuabl compon petroleum hydrocarbon pyrolysi proven effici method recov compon studi first investig pyrolysi kinet two differ method basi detail materi character take worker surround ecolog environ analysi object human health risk assess hhra ecolog risk assess evalu respect pyrolysi result show pyrolysi obdc divid three stage crack light hydrocarbon stage key control step pyrolysi process activ energi e increas gradual pyrolysi progress hhra result show pyrolysi could great reduc non carcinogen risk carcinogen risk ecolog risk respect howev carcinogen risk pyrolysi still higher critic valu | D059206;D010578 | T167;T109 |
36,265,403 | greenspac exposur poststrok disabl nationwid longitudin studi exposur greenspac report reduc stroke mortal lack evid regard poststrok disabl studi aim investig associ long term greenspac exposur risk poststrok disabl | D000068316;D020521 | T083;T047 |
36,265,402 | cadmium exposur adult across europ result hbmeu align studi survey object studi estim current exposur cadmium cd europ potenti differ countri geograph region determin exposur deriv european exposur level basi work provid european human biomonitor initi hbmeu establish framework align nation region hbm studi purpos cd exposur assess studi european countri iceland denmark poland czech republ croatia portug germani franc luxembourg includ urin year old adult sampl year n measur urin qualiti assur hbmeu qualiti assurancequ control scheme studi particip questionnair data post harmon spatial resolv extern data name cd concentr soil agricultur area phosphat fertil applic traffic densiti point sourc cd releas collect respect statist territori unit nut distinct geograph pattern observ cd level urin although data reveal differ specif studi site level exposur otherwis similar two time period within last decad democoph vs hbmeu align studi age depend alert valu cd urin exceed studi particip exceed differ studi locat rang studi largest extent exceed franc poland associ analysi individu food consumpt data avail particip questionnair show import contribut vegetarian diet overal exposur higher level vegetarian oppos non vegetarian comparison increas cd level due smoke use nut level extern data posit associ hbm data percentag cropland consumpt cd contain miner phosphat fertil reveal indic signific contribut miner phosphat fertil human cd exposur diet addit diet traffic point sourc releas identifi signific sourc exposur studi popul find studi support recommend efsa reduc cd exposur also estim mean dietari exposur adult eu close slight exceed toler week intak also indic regul protect popul suffici | D002104;D004784 | T131;T196;T057 |
36,265,396 | gata regul express annexin anxa associ epitheli mesenchym transit oral squamous cell carcinoma oral squamous cell carcinoma oscc disturb oral function qualiti life associ poor surviv like due develop cervic lymph node metastas epitheli mesenchym transit emt process cell acquir molecular alter facilit cell motil invas associ tumor metastasi emt chang also play import role induct lymph node metastasi oscc gata known earliest marker primit endoderm lineag gata inhibit de differenti emt human pancreat ductal adenocarcinoma cell promot emt howev oscc express function gata emt lymph node metastasi remain unclear therefor studi aim clarifi target gata oscc cell whether chang gata express affect emt oscc cell well associ gata lymph node metastasi result show gata knockdown oscc cell promot emt increas lymph node metastasi compar control cell wherea overexpress gata inhibit induct emt reduc lymph node metastasi addit annexin anxa largest type ca regul phospholipid bind protein eukaryot cell detect target gene gata anxa suppress vimentin express emt oscc therefor gataanxa cascad may potenti therapeut approach treatment lymph node metastas oscc patient | D009062;D002294;D006258 | T191 |
36,265,395 | efficaci mechan antinocicept effect cannabidiol acut orofaci nocicept induc complet freund adjuv male mus musculus mice object investig efficaci mechan cannabidiol orofaci nocicept induc complet freund adjuv cfa male mus musculus mice | D002185;D059225 | T121;T042;T109 |
36,265,394 | effect fluorid group dental eros associ abras human enamel systemat review network metanalysi systemat review evalu efficaci monoval polyval fluorid group compar non fluorid group prevent enamel eros associ abras situ studi | D014072;D014077;D057085 | T047;T046;T037 |
36,265,393 | effect cisplatin oral ulcer induc nocicept rat aim studi investig effect cisplatin preadministr oral ulcer mucos induc nocicept use experiment model rat | D019226;D052016;D013280 | T047;T046 |
36,265,392 | circular rna contribut oral squamous cell carcinoma progress mediat microrna axi studi aim explor role mechan circ regul oral squamous cell carcinoma progress oscc progress | D009062;D002294;D006258;D035683 | T123;T191;T114 |
36,265,389 | evalu impact blood donat tissu perfus sublingu microcircul dog pilot studi object assess feasibl sublingu microcircul evalu dog use sidestream dark field sdf imag devic evalu impact blood donat sublingu microcircul tissu perfus blood sampl macrocirculatori paramet tissu perfus paramet collect qualiti assess four video per individu per period retain analysi data present median st quartil rd quartil evalu sublingu microcircul sdf feasibl sedat dog good qualiti video could record dog median blood donat volum mlkg signific associ volum blood collect increas heart rate observ millilit blood drawn heart rate increas bpm ci p blood collect associ signific increas shock index estim ci p blood donat lactat concentr signific decreas mmoll p signific variat microcirculatori paramet observ conclus sublingu evalu microcircul sdf technolog feasibl dog present condit blood donat signific alter microcircul result need confirm larger popul | D009060;D001782 | T061;T098;T029 |
36,265,361 | anteced consequ share decis make patient chronic kidney diseas cross section survey chronic kidney diseas ckd strong negat impact patient find way improv ckd patient condit share decis make receiv much attent howev littl attent paid influenc anteced effect share decis make meanwhil advanc technolog bring new communic devic effect differ type communic use share decis make need address | D000086382;D051436 | T047;T067 |
36,265,355 | design synthesi biolog evalu novel sulfamoylbenzamid deriv hbv capsid assembl modul capsid assembl modul cam repres novel class antivir agent target hepat b virus hbv capsid disrupt assembl process nvr first cam demonstr antivir activ patient infect hbv howev relat low aqueous solubl moder activ human bodi halt develop nvr improv anti hbv activ drug like properti nvr design synthes seri nvr deriv notabl phenylboron acid bear compound b ec cc display compar anti hbv activ nvr ec cc besid b show improv water solubl gml ph compar nvr gml ph size exclus chromatographi sec quantif encapsid viral rna use demonstr b behav class ii cam similar nvr moreov molecular dynam md simul conduct ration structur activ relationship sar novel deriv understand key interact bind pocket provid use indic guid ration design effect anti hbv drug | D006515;D002213 | T005;T017 |
36,265,354 | ethyl aryl methyl oxothio dihydro h pyrimidin carboxyl silica support bismuth iii triflat catalyz synthesi antioxid activ novel ethyl aryl methyl oxothio dihydro h pyrimidin carboxyl synthes one pot three compon biginelli reaction aryl aldehyd ethyl acetoacet urea thiourea catalyt action silica support bismuth iii triflat lewi acid synthes compound structur character spectral ir h nmr c nmr spectroscop mass spectrometr element c h n analys present protocol deserv novel form product high yield short reaction time involv eco friend methodolog reusabl heterogen lewi acid catalyst titl compound screen vitro dpph free radic scaveng antioxid activ identifi j h f potenti antioxid obtain vitro result correl molecular dock admet qsar bioactiv toxic risk studi molecular finger print properti found silico bind affin identifi good correl vitro antioxid activ studi structur activ relationship molecular dock studi disclos strong hydrogen bond interact titl compound aspart acid asp aminoacid residu hck complex enzym haematopoiet cell kinas quercetin result toxicolog studi evalu potenti risk compound reveal titl compound safer drug ultim studi establish ligand antioxid potenti effect bind asp amino acid chain henc confirm inhibit growth reactiv oxygen speci vivo addit titl compound identifi potenti blood brain barrier penetr entiti effici central nervous system cns activ neuro protect antioxid agent | D000975;D001729 | T123;T121;T196;T039;T044 |
36,265,353 | repurpos n hydroxi thienopyrimidin dion htpd inhibitor human cytomegalovirus pul endonucleas synthesi biolog character terminas complex human cytomegalovirus hcmv requir viral genom packag cleavag critic terminas function metal depend endonucleas c terminus pul pul c previous report metal chelat n hydroxi thienopyrimidin dion htpd inhibitor human immunodefici virus hiv rnase h current work synthes new analog resynthes known analog two isomer htpd subtyp anti htpd syn htpd character inhibitor pul c remark vast major analog strong inhibit pul c biochem endonucleas assay ic valu nm rang cell base antivir assay analog inhibit hcmv low concentr select analog character biophys thermal shift assay tsa silico molecular dock result support pul c protein target inhibitor collect biochem antivir biophys silico data report herein indic isomer htpd chemotyp serv valuabl chemic platform design improv inhibitor hcmv pul c | D003587;D004720 | T005;T126;T116 |
36,265,352 | discoveri oxygen oleanol acid alkyl ester potent select fxr modul exhibit hyperglycemia amelior vivo farnesoid x receptor fxr ligand activ pursu treat metabol disord liver bile diseas among other start wide occur natur product oleanol acid oa discov potent select fxr modul oxygen oa alkyl ester assist molecular model repres compound b modul fxr downstream gene involv glucos lipid metabol cell signific improv hyperglycemia kkay fat mice fed high fat diet reduct mrna express gluconeogenesi gene pepck gpase studi provid new seri select fxr modul well vitro vivo evid potenti improv hyperglycemia diabet mice fxr antagon | D009828;D003921;D006943 | T123;T050;T109;T033;T047 |
36,265,337 | ovarian contrast enhanc ultrasonographi doppler fluxometri bitch postovulatori estrus corpora lutea format aim present studi evalu vascular featur canin ovari follicular phase format corpora lutea use doppler ultrasonographi contrast enhanc ultrasound ceus eight healthi bitch enrol studi evalu five differ timepoint estrous cycl establish vagin cytolog serum progesteron concentr ultrasonograph examin perform singl oper use acuson ssiemen machin equip linear multifrequ transduc mhz color code doppler evalu ovarian parenchyma perform investig aspect signal detect throughout differ timepoint puls wave doppler intraovarian arteri perform evalu spectral waveform doppler velocimetr paramet systol peak veloc spv cms end diastol veloc edv cms resist index ri pulsatil index pi ceus evalu ovari perform use vascular contrast agent sonovu bracco sao paulo brazil cadenc contrast puls sequenc cps siemen softwar order perform qualit quantit analysi perfus paramet pixel number peak intens ppi time peak intens ttp mean transit time mtt area curv auc colour code doppler evalu demonstr increas signal detect cycl progress blood flow initi detect colour pixel main ventral surfac ovari number colour pixel increas spread central region result circular like pattern around corpora hemorrhagica spectral waveform consist timepoint spv cms edv cms present numer trend slight statist differ timepoint wherea differ found ri pi ceus evalu demonstr increas pixel intens across timepoint quantit ceus analysi reveal statist differ ppi mtt auc ceus evalu ovari feasibl demonstr mark increas perfus paramet late postovulatori period demonstr applic assess canin corpora lutea develop | D010053;D018608 | T060;T023 |
36,265,299 | determin preval antibodi salmonella dublin dairi herd great britain quarter bulk tank test salmonella enterica subspeci enterica serovar dublin common salmonella serovar isol cattl great britain previous year caus wide varieti clinic present result signific welfar product concern infect herd bulk tank antibodi test undertaken everi three four month form basi erad monitor programm denmark netherland shown sensit specif cost effect way establish seropreval monitor infect herd level preval estim base quarter bulk tank test previous carri great britain studi recruit herd across great britain submit milk sampl quarter basi screen elisa salmonella dublin antibodi classifi herd accord danish erad scheme classif gave appar preval confid interv estim true preval confid interv take account test sensit specif herd complet quarter bulk tank test one posit bulk tank result | D012481;D002418 | T047 |
36,265,298 | preval relat factor enterocytozoon bieneusi cattl global systemat review meta analysi enterocytozoon bieneusi e bieneusi import zoonot microsporidian pathogen varieti host cattl reservoir host e bieneusi play import role epidemiolog e bieneusi howev systemat research preval e bieneusi cattl report systemat review meta analysi perform determin preval e bieneusi cattl six databas pubm web scienc springlink wanfang cnki vip use search relev studi quantiti e bieneusi infect cattl extract subject estim preval cattl use random effect model total forti articl countri chosen studi incept st june overal e bieneusi preval ci cattl highest preval e bieneusi south america lowest africa preval e bieneusi lower cattl age month higher preval compar cattl age month combin preval e bieneusi dairi cattl higher speci subgroup season e bieneusi preval cattl higher spring autumn summer winter e bieneusi preval natur graze cattl intens fed cattl total e bieneusi genotyp preval cattl genotyp found cattl previous found human global preval e bieneusi cattl relat geograph climat variabl evalu well data indic e bieneusi ubiquit cattl worldwid carri potenti risk infect human thus farm manag provid scientif mix nutrient improv cattl immun keep environ clean disinfect regular collect control e bieneusi transmiss cattl import econom public health | D021862;D016881;D002418 | T047;T004 |
36,265,267 | effect hyperoxia ventil recoveri general anesthesia random pilot studi parallel random control trial supplement inhal correct hypoxemia effect post anesthesia ventil remain unknown pilot trial test hypothesi hyperoxia increas time spent transcutan pco tcpco mmhg compar standard supplement | D018496 | T184 |
36,265,263 | interplay structur function connect earli stage parkinson diseas patient mechan under cognit disturb parkinson diseas pd poor understood like depend ongo degen process affect structur function connect fc pilot studi examin pattern fc alter cognit task use eeg structur characterist white matter wm pathway connect activ region earli stage pd eleven pd patient nine healthi control hcs underw eeg record auditori oddbal task mri scan sourc local perform gaussian mixtur model fit identifi brain region high power task perform area serv seed region connect analysi fc among region assess measur magnitud squar coher msc phase lock valu plv structur connect evalu use fiber track base diffus tensor imag dti paracentr lobul pl superior pariet lobul spl superior middl frontal gyrus smfg parahippocamp gyrus superior middl tempor gyri stg mtg demonstr increas activ task perform compar hcs pd show lower fc smfg pl smfg spl msc p p respect signific differ group observ plv measur dti metric along wm tract find demonstr earli pd cognit perform chang might attribut fc alter suggest fc affect earli degen process wherea structur damag promin advanc stage result diseas burden accumul | D010300 | T047 |
36,265,262 | elev brain adc appar diffus coeffici hiv associ neurocognit disord evolut treatment pilot studi thirti hiv infect patient develop hiv associ neurocognit disord hand despit virolog control previous publish neuro studi show neurocognit status improv intensifi antivir therapi studi part neuro studi aim studi appar diffus coeffici adc biomark neurolog improv | D038524;D015658 | T060;T047 |
36,265,245 | nanomi open sourc electron microscop hardwar softwar platform outlin public licens open sourc electron microscopi platform refer nanomi nanomi offer modular flexibl electron microscop platform util varieti applic microscopi educ develop proof principl experi use complement exist experiment apparatus compon ultra high vacuum compat electron optic element independ vacuum envelop individu optic compon mount mm inch diamet half pipe allow custom electron optic varieti purpos target capabl includ sem tem scan tem stem electron diffract ed kev incid electron energi intend imag resolut sem tem stem mode nm describ exist compon interfac among compon ensur compat interchang paper provid resourc consid build util nanomi | D004583;D012984 | T090;T073;T196;T170;T081 |
36,265,244 | surgic manag currarino syndrom elder patient infect pre sacral mass technic nuanc review literatur currarino syndrom cs rare autosom domin genet disord defin triad presacr mass anorect malform sacral bone dysplasia discov lesion often surgic treat avoid life threaten complic mening malign transform sacral teratoma syndrom usual diagnos childhood accur diagnosi adult present syndrom challeng delay treatment present case report diagnost surgic manag strategi cs present elder patient accompani review literatur | D000071056;D004065;D013122;D008581 | T019;T047;T190 |
36,265,243 | clinic featur outcom children admit pediatr intens care unit due posterior revers encephalopathi syndrom aim studi analyz clinic featur neuroimag find outcom children admit tertiari pediatr intens care unit picu due posterior revers encephalopathi syndrom pres | D054038;D006973 | T047 |
36,265,242 | neuroimag moyamoya angiopathi updat review moyamoya angiopathi mma rare condit character steno occlus termin portion intern carotid arteri andor proxim branch format collater vessel network moyamoya vessel chang result chronic ischemia brain parenchyma subsequ serious cerebrovascular accid prognosi mma could dramat improv diagnosi assess prompt accur also crucial defin indic optim time volum tactic revascular surgeri well longitudin observ treatment therefor necessari use strict criteria decis make includ radiolog criteria today world neuroimag valuabl diagnost tool continu evolv provid us inform structur function chang differ patholog condit howev due mma rariti neuroimag challeng purpos review summar contemporari knowledg regard neuroimag patient mma discuss main difficulti associ visual condit | D009072 | T047 |
36,265,223 | defect ser phosphoryl tp dysregul lipid metabol fatti accumul fatti liver suscept reveal lipidom tp gene well known tumour suppressor mutat eg prevent ser phosphoryl induc delet express inact p protein increas suscept tumour occur howev role tp gene maintain metabol homeostasi regul physio patholog activ still well understood studi aim use lipidom studi systemat approach understand relationship phenotyp effect tp mutat lipid relat endogen metabolit plasma liver sampl mice carri tp ser ala mutat wild type mice collect lipid extract liquid liquid extract method analyz rplc ltq ftms lipidom studi result indic defect ser phosphoryl tp lead lipid disturb eg triacylglycerol fatti accumul fatti liver suscept prefer femal histolog observ stain haematoxylin eosin valid lipidom find conclus fatti liver occurr may differ phenotyp one strong link tp mutat suscept femal lipidom techniqu detect great number endogen compound provid precis metabol inform may help improv person diagnosi chronic hepat diseas | D009369;D005234 | T047;T191 |
36,265,220 | differ effect high effici concentr pretreat method norovirus detect oyster mussel oyster mussel import vector norovirus nov effici pretreat method nov detect oyster base iso establish previous work effect type shellfish remain unknown therefor studi systemat compar differ standard modifi iso method detect nov oyster mussel use standard iso method recoveri rate nov oyster mussel compar p unpair test contrast virus recoveri rate oyster mussel signific improv modifi method also signific differ found virus recoveri rate two shellfish p unpair test result fold differ virus concentr addit limit detect probabl modifi iso method oyster mussel could reach copiesg digest gland final modifi iso method success appli commerci oyster mussel result indic signific differ nov recoveri rate two shellfish p one way analysi varianc summari modifi iso method show higher virus recoveri rate standard iso method would use essenti tool nov detect oyster mussel | D029322;D010125;D049872 | T005;T204 |
36,265,203 | metabol profil workflow cell extract target hydrophil interact liquid chromatographi tandem mass spectrometri studi target approach wide metabolit coverag develop cellular metabolom analysi use uhplc qtrap ms system oper schedul multipl reaction monitor smrm mode mrm ion pair acquir hela cell sampl untarget analysi use uhplc qtof ms swath acquisit complement miss metabolit pathway databas four differ cell extract protocol studi compar base experi seri involv calcul individu metabolit recoveri prepost extract spike u c isotop label standard methanolwat extract mixtur vv show best result two hilic ms method employ water premier beh amid column develop util two differ chromatograph condit mm ammonium format buffer addit adjust ph formic acid esi mode mm ammonium acet adjust ph acet acid esi mode one hundr sixti one metabolit success detect esi mode wherea detect negat ionize mode total number compound three differ biolog matric cover analyt system employ establish hilic method calibr valid base authent chemic standard u c label pichia pastori komagataella phaffii yeast extract intern standard cellular matrix hela cell within day day precis determin three differ qc concentr level entireti analyt inter intra day accuraci show valu rang assess recoveri entir rang matrix effect extract recoveri process effici evalu follow matuszewski protocol u c label pichia pastori metabolit extract intern standard eventu method util quantifi metabolit hela cell extract | D053719 | T063 |
36,265,198 | characterist masteri motiv relationship parent stress toddler languag delay masteri motiv multifacet psycholog forc stimul child master skill task posit associ languag relat compet children development delay might lower level motiv parent might face escal parent stress well aim studi identifi characterist masteri motiv toddler languag delay intergroup intragroup comparison investig associ specif compon parent stress toddler masteri motiv eighti chines speak taiwanes toddler age month parent fifti toddler languag delay thirti toddler typic develop particip studi languag delay group select base matern report vocabulari product mandarin chines communic develop inventori direct assess individu development test intellig test revis dimens masteri questionnair dmq preschool version parent stress index short form use measur three domain child masteri motiv parent compon parent stress respect toddler languag delay rate lower gross motor social masteri motiv peer typic develop howev show strengthweak intragroup characterist higher gross motor motiv lower social motiv children parent stress languag delay group signific negat correl masteri motiv compon parent child dysfunct interact negat associ toddler total masteri motiv social motiv two indic express aspect control toddler age cognit abil famili social econom status conclus necessari earli interventionist observ parent stress masteri motiv process earli intervent | D016487;D007805 | T033;T047;T054;T048 |
36,265,187 | coars grain ddcosmo interfac tinker ddx librari domain decomposit conductor like screen model effici way comput solvat energi solut within polariz continuum medium linear scale comput time despit effici applic larg system still challeng possibl acceler algorithm resort coars grain strategi paper present preliminari interfac molecular dynam packag tinker ddx librari interfac use test unit atom coars grain strategi allow us push ddcosmo limit comput solvat energi system million atom first present benchmark find optim discret discuss perform result obtain fine coars grain solvat energi calcul | D056004;D000465 | T066;T170;T044 |
36,265,185 | addit prognost valu echocardiograph follow pulmonari hypertens role right ventricular area strain outcom pulmonari hypertens ph relat right ventricular rv function remodel hypothes chang rv function especi area strain could provid increment prognost inform compar use baselin data therefor aim assess rv function chang baselin month follow evalu prognost valu ph patient use echocardiographi | D006976;D018497 | T046 |
36,265,184 | prognost implic mitral valv geometri patient secondari mitral regurgit coapt trial impact mitral valv geometri outcom mitraclip treatment secondari mitral regurgit mr examin therefor sought evalu associ mitral valv geometri outcom patient heart failur hf secondari mr treat guidelin direct medic therapi gdmt mitraclip | D006333;D019918;D008944 | T061;T047;T046 |
36,265,183 | enzymat record local hydrogen peroxid generat use genet encod enzym reactiv oxygen speci ros endogen generat live cell essenti cell signal howev excess ros generat caus oxid damag biomolecul implic various human diseas includ age develop vivo hydrogen peroxid monitor method use genet encod peroxidas apex base system confirm apex activ endogen h generat phenoxyl radic produc biotinyl signal ie biotin phenol fluoresc signal ie amplexr detect use fluoresc microscop observ subcellular target apex activ local h generat menadion treatment among endoplasm reticulum lumen lysosom target apex show highest respons upon addit menadion impli local h level space high increas menadion treatment use apex also found minimum amount menadion requir generat detect level h subcellular compart also check local h quench effect n acetylcystein use system apex genet express divers live organ eg cancer cell line mice fli worm yeast method effect use detect local generat endogen produc h divers live model | D006861;D024483 | T121;T127;T109;T197;T130 |
36,265,181 | chemoselect solut solid phase synthesi disulfid link glycopeptid glycosyl peptid protein wide employ strategi mimic import post translat modif modul physicochem properti peptid enhanc deliveri furthermor glycosyl via sulfur atom impart increas chemic metabol stabil result glycoconjug herein report simpl chemoselect procedur prepar disulfid link glycopeptid acet protect glycosylsulfenyl hydrazin shown high reactiv thiol group cystein residu within peptid solut part convent solid phase peptid synthesi protocol effici glycosyl methodolog unprotect carbohydr also demonstr avoid need deprotect step extend util disulfid link glycopeptid produc excel yield given import glycosyl peptid structur glycobiolog pharmacolog therapeut methodolog outlin provid easi access disulfid link glycopeptid molecul multipl biolog applic | D006020;D060327 | T059;T052;T116 |
36,265,178 | aqueous microfluid fabric multifunct bioactiv microcapsul promot wound heal wound heal involv multipl stage bodi respons includ hemostasi inflamm cell prolifer tissu remodel new materi design satisfi demand throughout differ stage wound heal cherish rare discuss introduc aqueous multiphas microfluid novel strategi fabric self assembl multifunct alkyl chitosanalgin microcapsul saam novel therapeut materi rapid blood coagul wound heal saam structur distinguish ultrathin shell polycation surfac rapid activ clot cascad intern porous dextran rich core fast absorpt blood exud featur endow saam excel hemostat properti acut hemorrhag moreov alkyl chitosan within microcapsul exhibit persist antimicrobi activ bactericid infect due amphiphil cation surfac besid cytokin safe load organ solvent free microcapsul releas precis promot prolifer epiderm cell support subsequ develop granul tissu suppress inflamm last stage wound heal abil fabric size tailor soft microcapsul realiz time sequenti function tissu repair present aqueous microfluid generat multifunct bioactiv saam creat versatil robust paradigm wound treatment | D048271 | T121;T109 |
36,265,174 | hospit wide intervent bill code captur complex care academ referr center downcod nonprofit healthcar institut account signific revenu loss turn affect amount qualiti care provid use inpati medic note assess complex care want quantifi visit code distribut largest tertiari care center west virginia improv document code found nation benchmark | D006278;D004282 | T089;T064;T170 |
36,265,173 | profession relationship industri acog committe statement develop manufactur pharmaceut agent medic devic assist physician pursuit educ goal object financi support various medic research educ program general industri seek optim profit provid use good servic howev industri prioriti may alway align ethic respons clinician promot best interest patient educ provid evid base instruct research ensur scientif integr investig minim actual perceiv conflict interest physician institut set guidelin employe regard accept interact industri repres committe statement american colleg obstetrician gynecologist committe ethic provid recommend manag profession relationship industri updat literatur review discuss preval regul effect industri involv clinic care educ research | D035843;D010820 | T062;T097 |
36,265,169 | synthesi thymidin conjug formylphenylboron acid potenti lysin target iminoboron revers coval enzym probe design revers coval molecul select target amino function lysin residu enzym protein high desir goal herein describ synthet methodolog use prepar seri thymidin link formylphenylboron acid probe interrog sugar nucleotid process enzym recogn thymidin first synthet strategi mitig need protect group manipul thymidin capit upon straightforward prepar isol reactiv azidothymidin alkyn cycloaddit partner instal either propargyl ethynyl phenyl keton deriv boron acid second strategi direct link formylphenylboron acid thymidin ether linkag instal use mitsunobu condit dibenzoylthymidin iminoboron format observ select probe | D008239;D001897 | T123;T121;T130;T116 |
36,265,167 | pillararen inspir macrocycl extend pillar n aren geminiaren conspectusmacrocycl compound primari tool supramolecular chemistri sinc establish due innat function featur molecular recognit complex rapid develop modern supramolecular chemistri also signific benefit creat new macrocycl distinct geometri properti instanc pillar n aren pillaren relat young generat star macrocycl host among well establish one eg crown ether cyclodextrin cucurbituril calixaren promot phenomen research hotspot world past decad although synthesi host guest properti various supramolecular function pillaren intens studi mani object limit challeng still ignor exampl high level pillar n aren n usual possess applic larg size caviti due structur fold synthes larg scale uncompetit cyclize process furthermor two function group must coval para connect repeat phenylen unit sever limit structur divers flexibl context develop seri pillaren inspir macrocycl pim use versatil modular synthet strategi past year aim break synthet limit tradit pillaren find new opportun challeng supramolecular chemistri beyond specif graft biphenyl unit pillaren backbon extend pillar n aren rigid nanomet size caviti could obtain reason synthet yield select remov hydroxyalkoxi substitut pillaren backbon lean pillar aren leggero pillar n aren enhanc structur flexibl caviti adapt obtain combin two type bridg mode pillaren calixaren smart macrocycl receptor two differ interconvert conform featur name geminiaren discov benefit synthet access facil function superior host guest properti solut solid state new famili macrocycl exhibit broad rang applic includ limit supramolecular assemblygelationpolym pollut detect separ porous organ polym crystallineamorph molecular materi hybrid materi control drug deliveri thus account summar research effort pim first present overview design modular synthesi summari derivat strategi thereaft particular attent paid structur featur supramolecular function applic explor final remain challeng perspect outlin futur develop hope account work stimul advanc synthet macrocycl chemistri supramolecular function system lead practic applic various research area | D047250 | T121;T109 |
36,265,164 | valu matern care use learn health system facilit action increas need deliv high valu health care discuss valu measur implement matern care learn health system high valu matern care produc highest level benefit women given cost pregnanc ill state cure remiss achiev believ patient report outcom integr compon benefit quantif measur valu furthermor care impact health outcom particular matern care also need consid patient report experi part defin level benefit howev move beyond tradit narrow passiv measur valu need partner stakehold identifi prioriti chang identifi evid achiev chang integr measur activ promot effect implement continu learn cycl learn health system robust framework implement learn health system develop could appli matern care | D008427;D000080891 | T058 |
36,265,135 | risk hospit mortal breakthrough sar cov infect vaccin type observ studi medic claim data sever risk factor identifi sever covid diseas scientif communiti paper focus understand risk sever covid infect vaccin ie breakthrough sar cov infect studi risk vaccin type age sex comorbid prior sar cov infect import polici maker plan vaccin effort | D000086382;D014765 | T129;T047;T121;T067 |
36,265,131 | novel nuclear magnet reson method posit specif carbon isotop analysi organ molecul signific impur introduc novel nuclear magnet reson nmr tool determin posit specif carbon c c isotop ratio within complex organ molecul analyt advanc allow us measur posit specif isotop ratio sampl contain impur nmr peak overlap signal interest method involv collect seri altern c coupl c decoupl h nmr spectra use nmr puls sequenc design optim temperatur stabil follow data reduct scheme allow signal interest isol signal impur method valid use glycin refer materi known c c ratio us geolog survey usg impur typic found amino acid sampl intent introduc follow valid method use determin posit specif c c ratio set usg l valin materi usg contain signific impur associ biolog origin l valin found contain distinct intramolecular isotop variabl c isotop spike usg usg clear detect preserv carbon isotop ratio respect carbon isotop abund beta gamma posit indic usg l valin obtain differ sourc usg analyt approach signific step forward field posit specif isotop analysi natur abund via nmr enabl investig sampl contain impur typic present sampl deriv natur sourc | D014633 | T123;T116 |
36,265,119 | tumor fraction correl detect action variant across gt circul tumor dna sampl profil circul tumor dna ctdna increas adopt manag solid tumor concurr increas avail comprehens ctdna panel howev variabl ctdna shed result variabl assay sensit studi relationship ctdna tumor fraction tf detect action alter across cancer type | D000074141;D009369 | T191;T114 |
36,265,118 | molecular character circul tumor dna pediatr rhabdomyosarcoma feasibl studi rhabdomyosarcoma rms rare neoplasm affect children young adult effort improv patient surviv undermin lack suitabl diseas marker plasma circul tumor dna ctdna shown promis potenti minim invas biomark monitor tool cancer howev remain underexplor rms aim determin feasibl identifi quantifi ctdna plasma marker diseas burden andor treatment respons use blood sampl rms mous model patient | D000074141;D009369;D018233 | T191;T114 |
36,265,116 | parent prefer surround time content consent convers clinic germlin genet test follow child new cancer diagnosi clinic genom test increas use direct pediatr cancer care mani center interest offer test tumor pair germlin tissu near time cancer diagnosi conduct studi better understand parent prefer surround time content consent convers clinic germlin genet test children cancer part real time cancer care | D010290;D009369 | T099;T191;T102 |
36,265,115 | quantifi valu molecular tumor board discord recommend rate drug cost avoid molecular tumor board mtbs provid intervent assist patient primari oncologist interpret applic precis oncolog avoid clinic financi toxic prescrib inappropri target therapi articl describ novel method illustr mtbs valu recommend discord rate report associ drug cost avoid data | D009369 | T191 |
36,265,114 | germlin test somat tumor test brca pathogen variant ovarian cancer optim sequenc test asco recommend women epitheli ovarian cancer germlin test brca mutat without germlin pathogen variant pv somat tumor test determin elig poli adp ribos polymeras inhibitor consequ major patient ovarian cancer germlin test somat test altern strategi tumor test first germlin test pv tumor andor signific famili histori object conduct cost effect analysi compar two test strategi | D000970;D010051 | T121;T191;T109 |
36,265,112 | develop valid machin learn approach leverag real world clinic narrat predictor surviv advanc cancer predict short term mortal patient advanc cancer remain challeng whether digit clinic text use build model enhanc surviv predict popul unclear | D000069550;D009369 | T191;T066 |
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