PMID
int64 35.7M
36.4M
| Title/Abstract
stringlengths 22
8.78k
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101
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stringlengths 4
64
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|---|---|---|---|
36,266,389
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systemat review meta analysi demonstr klotho emerg exerkin klotho anti age protein sever therapeut role pathophysiolog differ organ skelet muscl kidney avail evid suggest exercis increas klotho level regardless condit intervent shed light anti age protein emerg promis exerkin develop systemat review meta analysi order verifi role differ exercis train protocol level circul solubl klotho klotho protein systemat search cochran central regist control trial central medlin pubm embas cinahl ctgov pedro random quasi random control trial investig effect exercis train klotho level includ report analysi compris particip age rang year old klotho concentr increas signific chronic exercis train minimum week hedg g ci p moreov exercis train increas klotho valu regardless health condit individu exercis intervent except combin aerob resist train furthermor protocol durat volum seem influenc klotho concentr sinc effect meta analysi chang subgroup variabl altogeth circul klotho protein alter chronic exercis train might consid exerkin howev effect may influenc differ train configur includ protocol durat volum intens
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D055070
|
T061
|
36,266,387
|
influenc hydroxyapatit nanoparticl format calcium fluorid surfac layer enamel dentin vitro topic applic differ fluorid prepar consid gold standard oral prophylaxi measur prevent dentistri hydroxyapatit nanoparticl nano hap well receiv consider attent dental use past decad purpos vitro studi analyz interact nano hap differ fluorid prepar order investig possibl establish presenc nano hap reproduc calcium fluorid surfac layer specimen visual examin regard surfac coverag structur morpholog homogen stabil test seri base enamel dentin specimen obtain extract bovin teeth conduct therebi sodium fluorid olaflur elmex fluid ppm aqueous nano hap solut serv test product steril water refer first singl applic nano hap fluorid test min incub test solut surfac coverag examin scan electron microscopi sem furthermor sampl determin energi dispers x ray spectroscopi edx identifi present element surfac layer particular fluorid test calcium fluorid layer persist stabil sampl expos spray dental multifunct syring use maximum pressur maximum water suppli second applic protocol fluorid nano hap appli simultan third applic protocol use sequenti sem visualis show simultan sequenti addit nano hap led distinct chang surfac layer structur agglomer various size form obvious differ morpholog calcium fluorid globul cover surfac homogen spray multifunct syring easili applic pure fluorid compound result homogen calcium fluorid surfac layer higher persist comparison combin fluorid nano hap interact fluorid nano hap clear could prove enamel well dentin surfac combin applic nano hap fluorid negat effect stabil persist calcium fluorid surfac precipit
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D005459;D053758
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T121;T197;T073
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36,266,384
|
identif novel cerna network relat prognosi immun hnscc base integr bioinformat investig head neck squamous cell carcinoma hnscc character immunosuppress environ necessit develop new immunotherapi respons predictor studi aim build prognosi relat compet endogen rna cerna network base immun relat gene irg analyz immunolog signatur differenti express irg identifi bioinformat analysi gene express omnibus geo cancer genom atlas tcga immport databas final via upstream prognosi relat microrna mirna long noncod rnas lncrnas predict co express analysi built immun relat cerna network linchsa mir pplau relat hnscc patient prognosi cibersort analysi demonstr substanti differ infiltr immun cell hnscc plau close correl type cell includ cell cd r cell follicular helper r macrophag r methyl tumor immun dysfunct exclus tide analys reveal plau upregul like caus hypomethyl high plau express may associ tumor immun evas hnscc respect
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D062085;D035683;D006258
|
T123;T191;T114
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36,266,380
|
abstract concret concept convers concept allow us make sens world evid acquisit represent come studi singl decontextu word focus opposit concret abstract concept eg bottl vs truth signific step forward research concept consist investig onlin interact use studi examin linguist exchang analyz differ sub kind concept particip submit onlin task simul convers exchang respond sentenc involv sub kind concret tool anim food abstract concept ps philosoph spiritu emss emot social pstq physic spatio tempor quantit found differ content food evok interocept tool anim elicit materi spatial audit featur confirm sensorimotor ground ps emss yield inner experi eg emot cognit state introspect oppos pstq tie visual properti concret agenc crucial various concept elicit differ interact dynam abstract concept generat higher uncertainti interact exchang concret one investig concept situat interact open new possibl studi conceptu knowledg pragmat social aspect
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D003210;D065812
|
T041
|
36,266,377
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abund composit marin litter coast dardanell canakkal strait turkey amount human origin litter sea surfac water sediment beach increas decad initi describ marin coastal system marin litter ml nowaday common observ marin system even gigant island consist garbag gyre area atlant ocean relat signific problem ml collect seven station beach along dardanell first time period may may season region analyz term densiti weight ml categor materi type plastic rubber paper etc field use mix packag wast person use product fish wast etc total number weight ml studi item kg area respect densiti weight ml rang itemsm gm respect main ml compon plastic item term densiti weight accord materi type addit mix packag wast mpw common ml item term densiti weight accord usag accord clean coast index kilya st kepez st beach dirti seddulbahir st beach clean beach station neither dirti clean medium accord index end studi suggest region strategi made
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D001493;D014866
|
T083;T167
|
36,266,376
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hospit risk stratif algorithm asian elder patient limit research conduct asian elder patient age year hospit mortal predict st segment elev myocardi infarct stemi use deep learn dl machin learn ml use dl ml predict hospit mortal asian elder stemi patient compar convent risk score myocardi infract outcom malaysia nation cardiovascular diseas registri compris ethnic divers asian elder popul patient variabl help establish hospit death predict model timi score use predict mortal use dl featur select method ml algorithm main perform metric area receiv oper characterist curv auc dl ml model construct use ml featur select outperform convent risk score score timi auc dl built ml featur auc rang outscor dl built featur auc timi score underestim mortal elder timi predict higher mortal dl algorithm ml featur select algorithm identifi age fast blood glucos heart rate killip class oral hypoglycem agent systol blood pressur total cholesterol common predictor mortal elder multi ethnic popul dl outperform timi risk score classifi elder stemi patient ml improv death predict identifi separ characterist older asian popul continu test valid improv futur risk classif manag result
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D000072657
|
T047
|
36,266,374
|
genom respons human granulosa cell kgn melatonin specif agonistsantagonist melatonin receptor melatonin known modul follicl develop act sever molecular cascad via bind two specif receptor mt mt even though believ melatonin modul granulosa cell gc function still limit knowledg act human gc mt mt one implic effect melatonin metabol process domin follicl better character role receptor effect melatonin follicular develop human granulosa like tumor cell kgn treat specif melatonin receptor agonist antagonist gene express analyz rna seq technolog follow appropri normal applic fold chang cut fc p treatment list princip differenti express gene deg generat analysi major upstream regul suggest mt receptor may involv melatonin antiprolif effect reprogram metabol human gc activ pkb signal pathway data suggest melatonin may act complementari mt mt receptor modul human gc steroidogenesi prolifer differenti howev mt receptor may one implic transduc effect melatonin prevent gc lutein follicl atresia antral follicular stage stimul pka pathway
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D044122;D008550
|
T121;T116;T109;T192;T125
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36,266,372
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benchmark qualiti practic global pharmaceut manufactur advanc suppli chain resili past sever decad pharmaceut manufactur becom increas global suppli chain becom longer complex fragment pharmaceut product avail patient custom typic conform appropri standard suppli chain often affect disrupt event shock impact public health one approach assur avail qualiti pharmaceut product encourag drug manufactur invest qualiti manag matur qmm promot continu improv interest patient serv risk base drug shortag prevent mitig activ help proactiv manag suppli chain complex ensur avail drug paper demonstr adher certain qualiti practic enabl improv manufactur perform prior research identifi qualiti practic correl manufactur perform better understand qualiti practic character measur analyz research project conduct voluntari global studi pharmaceut manufactur establish global pharmaceut manufactur establish particip qualiti benchmark studi qbs provid data manufactur perform self assess adher qualiti practic analysi data found implement level select qualiti manag practic correl posit certain key perform indic kpis specif found signific posit correl deliveri perform ii applic qmm principl associ technic product
|
D004345;D019985
|
T081;T093
|
36,266,371
|
high throughput skim sequenc approach genotyp dosag estim identifi transloc develop next generat sequenc ngs enabl shift array base genotyp direct sequenc genom librari high throughput genotyp even though whole genom sequenc initi cost routin analysi larg popul breed genet studi continu advanc genom sequenc bioinformat provid opportun capit whole genom inform new sequenc platform routin provid high qualiti sequenc data suffici genom coverag genotyp various breed popul limit come time cost librari construct multiplex larg number sampl describ high throughput whole genom skim sequenc skim seq approach util broad rang genotyp genom character use optim low volum illumina nextera chemistri develop skim seq method combin sampl one multiplex librari use dual index barcod dual index barcod number sampl multiplex adjust depend amount data requir could extend sampl panel doubl haploid wheat line triticum aestivum cdc stanley x cdc landmark wheat barley aestivum x hordeum vulgar wheat wheatgrass triticum durum x thinopyrum intermedium introgress line well known monosom wheat stock genotyp use skim seq approach bioinformat pipelin develop various applic sequenc coverag rang per sampl use refer genom detect chromosom dosag identifi aneuploidi karyotyp introgress line skim seq data leverag recent advanc genom sequenc skim seq provid effect low cost tool routin genotyp genet analysi track identifi introgress genom region interest genet research appli breed program
|
D018745;D001467
|
T168;T002;T028
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36,266,370
|
cost analysi pre pector implant base breast reconstruct improv mastectomi skin flap viabil increas recognit anim deform follow sub pector implant placement transit toward pre pector breast reconstruct studi explor cost effect implant base breast reconstruct investig evalu cost respect pre pector versus sub pector breast reconstruct retrospect review patient underw mastectomi implant base breast reconstruct perform demograph surgic characterist pre pector sub pector cohort well match except reconstruct stage patient underw pre pector reconstruct like undergo singl stage instead two stage reconstruct comparison institut cost ratio reconstruct techniqu reveal sub pector approach cost vs p howev stratif later reconstruct stage fail demonstr differ cost reconstruct techniqu result confirm multivari linear regress reveal reconstruct techniqu independ variabl cost studi suggest pre pector breast reconstruct cost effect altern sub pector breast reconstruct may confer cost benefit strong associ direct implant breast reconstruct
|
D019928;D001943;D016462;D018427
|
T061;T191;T074
|
36,266,345
|
tumor produc age associ oncometabolit methylmalon acid promot cancer associ fibroblast activ drive metastat progress system metabol shift occur age local metabol alter tumor stroma communic cooper establish uniqu tumor microenviron tme foster cancer progress show methylmalon acid mma age increas oncometabolit also produc aggress cancer cell activ fibroblast tme reciproc secret il load extracellular vesicl ev drive cancer progress drug resist metastasi cancer associ fibroblast caf releas ev cargo modifi result reactiv oxygen speci ros generat activ canon noncanon tgf signal pathway ev associ il function stroma tumor messeng activ jakstat tgf signal pathway tumor cell promot pro aggress behavior find defin role mma caf activ drive metastat reprogram unveil potenti therapeut avenu target mma nexus age tumor microenviron metastasi
|
D000072645;D009369;D000067128
|
T026;T191;T025
|
36,266,343
|
rna g quadruplex structur contribut cold adapt plant nucleotid composit suggest infer gene function ecolog adapt speci distinct environ howev under biolog function nucleotid composit dictat environment adapt larg unknown systemat analyz nucleotid composit transcriptom across plant kp correspond habitat intrigu find plant grow cold climat guanin g enrich transcriptom prone form rna g quadruplex structur immunofluoresc detect vivo structur profil reveal rna g quadruplex format plant global enhanc respons cold cold respons rna g quadruplex strong enhanc mrna stabil rather affect translat disrupt individu rna g quadruplex promot mrna decay cold lead impair plant cold respons therefor propos plant adopt rna g quadruplex structur molecular signatur facilit adapt cold evolut
|
D054856
|
T086
|
36,266,342
|
acut delet tet enzym result aneuploidi mous embryon stem cell decreas express khdc tet ten eleven transloc dioxygenas effect dna demethyl success oxid methyl group methylcytosin mc dna human mous model tet loss function link dna damag genom instabl oncogenesi show acut delet three tet gene brief exposur tripl flox cre ert express mous embryon stem cell mesc hydroxytamoxifen result chromosom mis segreg aneuploidi moreov embryo lack three tet protein show strike variat blastomer number nuclear morpholog cell stage transcript profil reveal mrna encod kh domain protein khdc filia downregul tripl tet defici mesc concomit increas methyl cpg dinucleotid vicin khdc gene restor khdc level tripl tet defici mesc prevent aneuploidi thus tet protein regul khdc gene express tet defici result mitot infidel genom instabl mesc least part decreas express khdc
|
D000782;D049308;D004268;D000066450
|
T123;T116;T025;T049;T126
|
36,266,340
|
nima relat kinas regul phosphoryl essenti myosin light chain heart adapt chang hemodynam demand regulatori mechan modul actin myosin kinet calcium depend independ mechan investig posttransl modif human essenti myosin light chain elc identifi nima relat kinas nek interact elc nek high express heart interact elc calcium depend silenc nek result blunt calcium depend elc phosphoryl crisprca mediat disrupt nek lead cardiomyopathi zebrafish bind elc mediat via protein kinas domain nek causal relationship nek activ elc phosphoryl demonstr genet sensit vivo final observ signific upregul elc phosphoryl dilat cardiomyopathi patient provid uniqu map human elc phosphoryl site summari nek mediat elc phosphoryl calcium depend regulatori system mediat cardiac contract inotropi
|
D018994;D000199
|
T123;T116
|
36,266,339
|
growth temperatur chromatin archaea dna cell associ protein constrain structur affect dna templat process includ transcript replic hu histon main constitu chromatin bacteria eukaryot respect except archaea contrast divers repertoir nucleoid associ protein nap analys evolutionari ecolog driver divers combin phylogenom survey known predict nap quantit proteom data identifi diaforarchaea hotb nap gain loss experiment valid candid nap two member clade thermoplasma volcanium methanomassiliicoccus luminyensi proteom analysi across divers sampl archaea reveal nap invest vari total protein variat predict growth temperatur propos high level chromatin evolv mechan prevent uncontrol helix denatur higher temperatur implic origin chromatin archaea eukaryot
|
D001105;D040901
|
T194;T091
|
36,266,338
|
potenti genom infecti diseas forecast genom technolog led tremend gain understand pathogen function evolv interact pathogen divers measur high precis resolut part past decad sequenc technolog increas speed capac decreas cost alongsid use model forecast emerg size infecti diseas outbreak risen highlight coronavirus diseas pandem also due model advanc allow rapid estim emerg outbreak inform monitor coordin resourc deploy howev genom studi remain larg retrospect contain high resolut view pathogen diversif evolut context select often align design intervent miss opportun pathogen diversif core press infecti public health challeng intervent need take mechan virul understand pathogen diversif account perspect assess converg field discuss current challeng face surveil specialist model want har genom data propos next step integr longitudin sampl genom data statist learn interpret model make reliabl predict futur
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D000086382;D003141
|
T047;T067
|
36,266,337
|
integr host microb plasma metagenom sepsi diagnosi prospect cohort critic ill adult carri integr host pathogen metagenom rna dna next generat sequenc mngs whole blood n plasma n critic ill patient follow hospit admiss assign patient sepsi group basi clinic microbiolog criteria whole blood gene express data distinguish patient sepsi patient non infecti system inflammatori condit use train bag support vector machin bsvm classifi area receiv oper characterist curv auc train set auc held valid set plasma rna also yield transcript signatur sepsi sever gene previous report sepsi biomark bsvm sepsi diagnost classifi auc train set auc valid set pathogen detect perform plasma mngs vari basi pathogen site infect improv detect virus develop secondari transcriptom classifi auc train set auc valid set combin host microbi featur develop integr sepsi diagnost model identifi microbiolog confirm sepsi case predict sepsi suspect indetermin sepsi case summari suggest integr host transcript profil broad rang metagenom pathogen detect nucleic acid promis tool sepsi diagnosi
|
D016638;D018805
|
T047;T046
|
36,266,336
|
crispr base oligo recombin priorit apicomplexan cystein drug discoveri nucleophil amino acid import coval drug develop yet underutil anti microbi target chemoproteom technolog develop mine chemic access residu via intrins reactiv toward electrophil probe discern chemic reactiv site contribut protein function therefor priorit drug discoveri address develop crispr base oligo recombin core platform support rapid identif function priorit ration target chemic reactiv site haploid system approach coupl protein sequenc function biolog fit live cell profil electrophil sensit proteinogen cystein eukaryot pathogen toxoplasma gondii priorit function site use core electrophil sensit cystein decor ribosom found critic parasit growth target base screen identifi parasit select anti malari lead molecul valid apicomplexan translat machineri target ongo coval ligand develop
|
D014122
|
T204
|
36,266,335
|
divers marr bacteri regul auxin catabol plant microbiom chemic signal plant microbiom drastic effect microbi communiti structur host growth develop previous demonstr auxin metabol signal interfer perform bacteri genus variovorax via auxin degrad locus essenti maintain stereotyp root develop ecolog relev bacteri synthet communiti dissect variovorax auxin degrad locus defin gene iadd necessari suffici indol acet acid iaa degrad signal interfer determin crystal structur bind properti operon marr famili repressor iaa auxin auxin degrad operon identifi across bacteri tree life defin two distinct type basi gene content metabol product iac like iad like structur marr repres auxin degrad operon type establish distinct iaa bind pocket comparison repres iaa degrad strain divers bacteri genera colon arabidopsi plant show degrad iaa strain contain iad like auxin degrad operon interfer auxin signal complex synthet communiti context suggest iad like operon contain bacteri strain includ variovorax speci play key ecolog role modul auxin plant microbiom
|
D017360;D029681;D064307
|
T032;T116;T002;T028;T001
|
36,266,334
|
flexibl learn quantum state generat queri neural network deep neural network power tool character quantum state exist network typic train experiment data gather quantum state need character possibl train neural network offlin differ set state introduc network train classic simul data fiduci set state measur later use character quantum state share structur similar fiduci state littl guidanc quantum physic network build data driven represent quantum state use predict outcom statist quantum measur perform yet state represent produc network also use task beyond predict outcom statist includ cluster quantum state identif differ phase matter
|
D016571;D000069550
|
T170;T066
|
36,266,333
|
cryo em structur thermostabil prestin provid mechanist insight under outer hair cell electromotil outer hair cell elecromotil driven prestin essenti mammalian cochlear amplif report cryo em structur thermostabil prestin pres ts complex chlorid sulfat salicyl resolut central posit charg caviti allow flexibl bind various anion speci like account known distinct modul nonlinear capacit nlc differ anion comparison pres ts structur recent prestin structur suggest rigid bodi movement core gate domain provid mechanist insight prestin inhibit salicyl mutat dimer interfac sever diminish nlc suggest stabil gate domain facilit core domain movement therebi contribut express nlc find advanc understand molecular mechan under mammalian cochlear amplif
|
D027321;D002712
|
T123;T196;T034;T116
|
36,266,330
|
rapid antibiot suscept test speci identif mix sampl antimicrobi resist increas problem global scale rapid antibiot suscept test ast urgent need clinic enabl person prescript high resist environ limit use broad spectrum drug current rapid phenotyp ast method includ speci identif id leav time consum plate cultur avail option id need make sensit call describ method perform phenotyp ast singl cell level microfluid chip allow subsequ genotyp situ fish stratifi phenotyp ast respons speci individu cell possibl determin suscept profil speci mix sampl h proof principl studi demonstr oper four antibiot mix sampl combin seven speci
|
D000900;D044085
|
T090;T121;T195
|
36,266,329
|
effici achiev enter autonomi facilit resolut liver injuri necrot enterocol induc short bowel syndrom children short bowel syndrom sbs high risk intestin failur associ liver diseas ifald aim retrospect follow studi compar wean parenter nutrit pn ifald necrot enterocol nec non nec induc sbs altogeth patient neonat sbs treat multidisciplinari intestin failur unit nec n non nec sbs n includ follow least year median age year interquartil rang occurr characterist ifald assess liver biopsi obtain median age year n serum liver biochemistri overal nec patient less end jejunostomi autolog intestin reconstruct surgeri perform compar non nec patient remain small bowel anatomi compar group cumul wean pn frequent durat pn shorter among nec patient p overal cumul probabl histolog ifald lower among nec patient whole follow period p year p nec patient lower alt ggt level last follow p univari cox regress analysi absenc end jejunostomi nec diagnosi longer remain small bowel length multidisciplinari treatment prematur predict wean pn nec diagnosi lower birth weight addit multidisciplinari care protect histolog ifald neonat nec induc sbs reach enter autonomi earlier non nec sbs associ effici resolut histolog ifald among long term survivor
|
D012778;D020345;D007410;D017093;D008107;D007232;D005315
|
T033;T047
|
36,266,328
|
assess mllerian mimicri north american bumbl bee use human percept despit broad recognit mimicri among bumbl bee distinct north american mimicri ring yet defin due part preval intermedi imperfect mimic region employ general approach use human percept categor mimicri ring among north american bumbl bee map speci distribut north american ecoregion visual test geograph concord among similar color speci analys suggest five mimicri ring north american bumbl bee mimicri complex one broad distribut group mix intermedi color form describ black mimicri ring black cloak mimicri ring eastern yellow mimicri ring red mimicri ring western yellow mimicri ring well mix group test hypothes mimicri ring examin insect particip mimicri ring describ mimicri ring vital step enabl futur analys imperfect mimicri intermedi mimicri addit analys insect mimic bumbl bee
|
D000067558
|
T070
|
36,266,324
|
mettl mediat chemoresist enhanc aml home engraft via itga chemoresist leukemia relaps one common caus death acut myeloid leukemia aml patient homingengraft bone marrow bm crucial step aml cell acquir chemoresist interact stromal cell compon crosstalk modif homingengraft report perform comprehens high throughput analys includ rna sequenc cr complet remiss relaps aml patient revers phase protein array chemoresist cell identifi mettl key player regul aml chemoresist mettl mediat modif prove induc chemoresist vitro vivo furthermor aml homingengraft discov enhanc upregul mettl chemoresist cell homingengraft drug resist associ phenotyp chemoresist cell could revers mettl inhibitor mechanist mettl extend half life itga mrna methyl increas express itga protein enhanc homingengraft aml cell result provid insight function modif interact aml cell bm nich clarifi relationship mettl aml homingengraft suggest therapeut strategi treatment refractoryrelaps aml mettl inhibitor
|
D019008;D015470
|
T191;T038;T042
|
36,266,322
|
novel metallom profil non carcinogen risk assess botan ingredi use herbal phytopharmaceut dietari product use hr icp sfms knowledg element concentr botan extract relev assur consum protect given increas interest plant base ingredi studi demonstr success multi element investig order address lack comprehens profil data botan extract report first time metallom profil arnica bush vetch sweet cice yellow rattl bogbean rock tea tuft catchfli key element composit quantifi use valid hr icp sfms method g kg found high variabl differ plant lithium beryllium molybdenum cadmium tin barium platinum mercuri thallium lead bismuth titanium vanadium chromium cobalt nickel copper compendi permiss limit exceed overal evid health risk consum could determin consumpt investig plant reason intak rate mathemat risk model edi cdi hq hi estim level safe oral threshold cd pb higher intak respect plant deriv materi follow high consumpt certain plant sampl categoris potenti unsaf due cumul exposur cu cd hg pb pca suggest potenti influenc post harvest process cr ti v level commerci acquir plant materi compar wild collect farm grown plant moreov strong correl observ pb bi v bi sn tl mo occurr studi may support futur research provid robust methodolog accompani refer profil suitabl qualiti evalu essenti element andor metal contamin botan ingredi
|
D002104;D008628
|
T131;T196
|
36,266,321
|
open data impact citizen behavior assess face mask panic buy behavior covid pandem data essenti digit solut support citizen everyday behavior open data initi expand worldwid last decad yet investig actual usag open data evalu impact insuffici thus paper examin exemplari use case open data earli stage covid pandem assess impact citizen base quasi experiment method studi found publish local store real time face mask stock level open data may influenc peopl purchas behavior result indic reduc panic buy behavior consequ open access inform form onlin mask map furthermor result also suggest open data base countermeasur equal impact everi citizen rather vari among socioeconom condit particular educ level
|
D000086382
|
T047;T067
|
36,266,320
|
deep learn base classif lung opac chest x ray radiograph batch control sensit regul studi implement system classifi lung opac frontal chest x ray radiograph also propos train method address class imbal problem present dataset particip radiolog societi america rsna pneumonia detect challeng use dataset provid rsna research use convolut neural network implement train procedur term batch control manipul data distribut posit negat case train batch batch control method regul stabil perform deep learn model allow adapt sensit network model meet specif applic convolut neural network practic classifi lung opac chest x ray radiograph batch control method advantag sensit regul optim class unbalanc dataset
|
D000077321;D011014
|
T047;T050;T066
|
36,266,319
|
lrpcd ligand tissu type plasminogen activ macroglobulin solubl cellular prion protein distinct co receptor requir activ cell signal ldl receptor relat protein lrpcd bind divers ligand mani activ cell signal herein compar three lrp ligand inhibit inflammatori respons trigger lipopolysaccharid lps includ enzymat inact tissu type plasminogen activ ei tpa activ macroglobulin prp solubl deriv nonpathogen cellular prion protein prp c bone marrow deriv macrophag n methyl aspart receptor essenti three lrp ligand activ cell signal inhibit lps induc cytokin express intact lipid raft also essenti absolut requir lrp lrp decreas ei tpa concentr requir activ cell signal antagon lps essenti mimick role prp co receptor membran anchor prp c also function co receptor ei tpa decreas ligand concentr requir cell signal lps antagon howev concentr ei tpa suffici increas cell signal lps antagon occur independ prp c prp lrp ligand group activ cell signal independ membran anchor prp c ei tpa prp inhibit lps induc lrp shed macrophag process convert lrp pro inflammatori product differ co receptor requir anti inflammatori activ may explain lrp ligand vari abil target macrophag differ differenti state
|
D008070;D045384
|
T123;T116;T109
|
36,266,317
|
pm forecast urban area base deep learn decomposit method rapid growth industri urban result high concentr air pollut environ thus caus sever air pollut excess emiss particul matter ambient air negat impact health well human societi therefor accur forecast air pollut concentr crucial mitig associ health risk studi aim predict hour pm concentr urban area malaysia use hybrid deep learn model ensembl empir mode decomposit eemd employ decompos origin sequenc data particul matter sever subseri long short term memori lstm use individu forecast decompos subseri consid influenc air pollut paramet h ahead forecast output forecast aggreg obtain final forecast pm concentr studi util two air qualiti dataset two monitor station valid perform propos hybrid eemd lstm model base various data distribut spatial tempor correl propos dataset analys determin signific input paramet forecast model lstm architectur consist two lstm layer data decomposit method ad data pre process stage improv forecast accuraci final comparison analysi conduct compar perform propos model deep learn model result illustr eemd lstm yield highest accuraci result among deep learn model hybrid forecast model prove superior perform compar individu model
|
D000077321;D000397;D000393
|
T131;T069;T066;T080
|
36,266,316
|
spontan instrument avoid learn social context adapt social environ requir learn avoid potenti harm situat encount aggress individu threaten facial express evok automat stimulus driven reaction whether avers motiv valu suffic drive instrument activ avoid remain unclear ask freeli choos differ action altern particip spontan without instruct monetari reward develop prefer choic maxim probabl avoid angri individu sit away wait room particip show clear behavior sign instrument learn even absenc explicit avoid strategi inter individu variabl learn depend particip subject evalu sensit threat approach feedback counterfactu learn best account avoid behavior especi particip develop explicit avoid strategi result demonstr implicit defens behavior social context like product sever learn process includ instrument learn
|
D001362;D003216
|
T041
|
36,266,315
|
sugar termin carbon nanodot stimul osmolyt accumul ros detoxif allevi salin stress vigna radiata recent time nanotechnolog emerg effici tool manag advers effect environment stress plant connect carbon nanodot cnds report amelior negat impact salin stress surfac modif cnds believ augment stress allevi potenti howev littl known potenti surfac function cnds purview two sugar trehalos glucos termin cnds cnpt cnpg synthes assess stress allevi effect vigna radiata salt sensit legum seedl subject differ concentr nacl mm synthes cnds cnpt cnpg exhibit hydrodynam size nm zeta potenti mv nm core water solubl nanomateri exhibit characterist fluoresc emiss properti viz orang greenish yellow cnpt cnpg respect success function sugar molecul cnd core confirm use ftir xrd afm result indic applic cnds improv seed germin growth pigment content ionic osmot balanc import antioxid defens decreas ros accumul time cnpt cnpg exhibit toxic allium cepa root tip bioassay therefor conclud sugar termin cnds improv plant respons salin stress facilit sugar uptak aerial part seedl
|
D000070658
|
T002
|
36,266,314
|
central role prominin lipid raft liver regener prominin lipid raft protein requir maintain cancer stem cell properti hepatocarcinoma cell line physiolog role liver well studi investig role prominin lipid raft liver regener show express prominin increas partial hepatectomi ccl inject hepatocyt prolifer liver regener attenu liver specif prominin knockout mice compar wild type mice detail mechanist studi reveal prominin interact interleukin signal transduc glycoprotein confin lipid raft stat signal il effect activ overexpress glycosylphosphatidylinsositol anchor first extracellular domain prominin domain bind gp rescu prolifer hepatocyt liver regener liver specif prominin knockout mice summari prominin upregul hepatocyt liver regener recruit gp lipid raft activ il gp stat axi suggest prominin might promis target therapeut applic liver transplant
|
D008115;D015850
|
T129;T116;T042
|
36,266,312
|
physicochem structur analysi coal discard sewag sludg co htc deriv biochar sustain carbon economi evalu liquid product studi focus hydrotherm treatment htc coal tail ct coal slurri cs co hydrotherm treatment co htc ct cs sewag sludg assess potenti increas carbon content hydrochar produc enabl sustain carbon economi optim combin methodolog respons surfac methodolog use studi relationship import process paramet name temperatur pressur resid time coal sewag sludg ratio carbon yield produc hydrochar optim condit hydrochar coal tail hct hydrochar coal slurri hcs c bar min increas fix carbon respect total carbon content improv respect wherea ash content coal discard decreas compar ct cs respect optim co htc condit c bar min hydrochar blend coal discard sewag sludg hcb increas fix carbon dri basi total carbon content compar ct cs respect carbon yield hct hcs hcb respect htc co htc increas calorif valu ct cs mjkg mjkg respect result show co htc condit raw biomass undergo dehydr decarboxyl result decreas hydrogen oxygen result hct hcs hcb respect htc co htc optim condit increas specif surfac area feedstock g g g g ct cs respect total pore volum rose cm g cm g cm g cm g prove abil htc produc high qualiti hydrochar coal discard alon conjunct sewag sludg precursor decontamin pollut water soil decontamin applic solid combust energi storag environment protect
|
D012722;D002244
|
T121;T196;T069
|
36,266,311
|
blood monocyt deriv cd macrophag contribut antitumor immun glioblastoma infiltr tumor associ macrophag tam known imped immunotherapi glioblastoma gbm howev tam heterogen clear marker distinguish immunosuppress potenti immun activ popul identifi subset cd macrophag promot anti tumor microenviron gbm use singl cell transcriptom analysi find cd macrophag human mous glioma produc pro inflammatori chemokin lead accumul cell nk cell cd express macrophag facilit phagocytosi apoptot glioma cell henc tumor specif cell respons deplet cd macrophag lead function impair antitumor lymphocyt poorer surviv glioma bear mice show nk cell deriv ifn critic accumul blood monocyt deriv cd macrophag glioma work thus identifi well distinguish tam subset promot antitumor immun gbm identifi key factor might shift balanc immunosuppress anti tumor tam
|
D005909;D005910;D001932
|
T191
|
36,266,308
|
nephroprotect action passiflora eduli streptozotocin induc diabet present studi aim evalu therapeut effect passiflora eduli fruit peel aqueous afa extract adjuv insulin confer nephroprotect streptozotocin induc diabet male wistar rat divid four group base treatment receiv day diabet db control ctl insulin in insulin afa extract in afa mrna protein express level podocyt nephrin podocin wt tubular megalin protein measur kidney tissu specimen urin biochem paramet kidney histopatholog also examin herein in afa group show superior glycem control result reduct urinari albumincreatinin ratio mainten baselin level nphs nphs wt lrp mrna express prevent protein loss kidney tissu urinari space along mainten glomerular basement membran thick hyalin glomerular tubulointerstiti fibrosi valu approxim ctl group signific lower db group therefor result suggest anti diabet agent afa extract adjuv insulin could reduc potenti prevent diabet kidney diseas
|
D029598;D003921;D003928
|
T121;T050;T109;T168;T047;T002
|
36,266,307
|
quantit evalu impact domest aviat control measur spread covid china quantit evalu impact domest aviat control measur spread covid china number intern flight march septemb simul number flight march septemb without implement aviat control measur addit proport asymptomat person delay case report adjust estim preval countri period calcul estim import case estim import case assign day weight estim daili report case obtain base actual daili number domest case china effect reproduct number formula see text calcul base delay distribut basic reproduct number formula see text distribut generat time distribut report previous studi gaussian process use estim effect time vari formula see text estim formula see text compar actual formula see text estim import case increas signific compar actual number import case estim import case main concentr north america europ march april gradual increas mani east asian countri may septemb differ predict formula see text actual formula see text statist signific estim import case estim formula see text increas compar actual situat paper quantit prove chines aviat control measur signific suppress covid epidem conduc promot appli measur
|
D000086382;D058872;D001359
|
T090;T067;T056;T089;T047
|
36,266,306
|
synthet biolog instruct transderm microneedl patch traceabl photodynam therapi aminolevulin acid base photodynam therapi heavili depend biolog transform effici aminolevulin acid protoporphyrin ix lack effect deliveri system imag navig major hurdl improv accumul protoporphyrin ix optim therapeut paramet herein leverag synthet biolog approach construct transderm theranost microneedl patch integr aminolevulin acid catalas co load tumor acid respons copper dope calcium phosphat nanoparticl effici aminolevulin acid base photodynam therapi maxim enrich intratumor protoporphyrin ix show continu oxygen generat catalas vivo revers tumor hypoxia enhanc protoporphyrin ix accumul block protoporphyrin ix efflux downregul hypoxia induc factor ferrochelatas upregul protoporphyrin ix biosynthesi provid exogen aminolevulin acid upregul ala synthetas vivo fluorescencephotoacoust duplex imag monitor intratumor oxygen satur protoporphyrin ix metabol kinet simultan approach thus facilit optim therapeut paramet differ cancer realiz ca cu interfer enhanc repeat photodynam therapi make theranost patch promis clinic practic
|
D010778;D009369
|
T061;T191
|
36,266,304
|
structur insight ligand bind mechan aryl hydrocarbon receptor aryl hydrocarbon receptor ahr member basic helix loop helix bhlh per arnt sim pas famili transcript factor play import role regul xenobiot metabol cellular differenti stem cell mainten well immun recent ahr gain signific interest drug target develop novel cancer immunotherapi drug detail understand ahr ligand bind hamper decad lack three dimension structur ahr pas b domain present multipl crystal structur drosophila ahr pas b domain includ apo ligand bound ahr nuclear transloc arnt pas b bound form togeth biochem cellular assay data reveal structur featur ahr pas b domain provid insight mechan ahr ligand bind provid structur basi futur develop ahr target therapeut
|
D018336;D051784
|
T123;T116;T192
|
36,266,303
|
multi speci occup model suggest interspecif interact among three ungul speci speci sympatr distribut influenc ecosystem dynam impact presenc co exist speci assess coexist role interspecif interact landscap variabl necessari know speci co occurr space indian himalayan region studi complet lack due limit effort made main complex terrain inaccess landscap featur use camera trap sign survey multi speci occup framework understand influenc environment variabl occup detect probabl speci specif pair wise interact three ungul uttarkashi result conclud individu speci occup probabl relat environment variabl presenc absenc interact speci top model show evid interspecif interact among speci pair occup probabl speci one vari presenc absenc anoth speci overal activ pattern similar among three speci found activ throughout day activ overlap sambar bark deer dhat valu consider higher bark deer goral dhat valu find present studi use conserv manag ungul indian himalayan adjoin region
|
D017753;D003670
|
T070;T082;T015
|
36,266,302
|
atom resolut protein allosteri multi state structur pdz domain recent methodolog advanc solut nmr allow determin multi state protein structur provid insight structur dynam correl protein site atom resolut demonstr present work well studi pdz domain protein human tyrosin phosphatas e protein allosteri predict two state protein structur calcul free form complex ra gef peptid use exact nuclear overhaus effect eno method apo protein alloster conform select step compris almost domain detect open ligand welcom state close state obstruct bind site chang distanc sheet helix sidechain residu lys lys observ induc fit type apo holo structur rearrang line previous publish evolut base analysi cover domain partial overlap protein allosteri open form present structur studi highlight presenc dedic high optim complex dynam interplay pdz domain owe structur dynam landscap
|
D054731;D011506
|
T123;T116;T082
|
36,266,301
|
high throughput screen mesenchym stem cell line use deep learn mesenchym stem cell mscs increas use regen therapi patient preclin clinic phase various diseas howev main limit therapi includ function heterogen lack appropri qualiti control qc method function screen msc line thus clinic outcom inconsist recent machin learn ml base method conjunct singl cell morpholog profil propos altern convent vitrovivo assay evalu msc function method perform silico analys msc function train ml algorithm find high nonlinear connect msc function morpholog although approach promis limit extens high content singl cell imag requir moreov manual identifi morpholog featur general experiment set address limit propos end end deep learn dl framework function screen msc line use live cell microscop imag msc popul quantit evalu various convolut neural network cnn model demonstr method accur classifi vitro msc line highlow multilineag differenti stress endur muse cell marker multipl donor total cell imag obtain msc line classifi two group accord muse cell marker analyz immunofluoresc stain fac optim densenet model show area curv auc accuraci f sensit specif posit predict valu negat predict valu therefor dl base framework conveni high throughput method could serv effect qc strategi futur clinic biomanufactur process
|
D000077321;D059630
|
T025;T066
|
36,266,300
|
studi impact role stress engin intent leav indian construct firm construct job stress high employe turnov one signific issu affect growth develop construct firm worldwid studi examin relationship role stress intent leav well role emot exhaust job satisfact mediat role stress intent leav engin work construct sector sampl studi consist three hundr sixti engin work privat construct firm across southern part india relationship studi variabl examin use structur equat model result studi reveal signific posit relationship role conflict intent leav wherea direct relationship role ambigu role overload intent leav signific term mediat emot exhaust play signific mediat compon role stress intent leav time role job satisfact signific role ambigu intent leav role ambigu negat influenc job satisfact subsequ increas engin turnov intent emot exhaust caus due role stress identifi one signific predictor engin intent leav thus construct organ focus redesign construct job reduc role stress emot exhaust retain engin work
|
D033182;D010563
|
T081;T041
|
36,266,299
|
de novo transcriptom assembl conium maculatum l identifi candid gene coniin biosynthesi poison hemlock conium maculatum l notori weed contain potent alkaloid coniin enzym coniin biosynthesi far character util next generat rna sequenc approach report first ever transcriptom sequenc five organ poison hemlock develop fruit flower root leaf stem use de novo assembl approach deriv transcriptom assembl contain transcript assembl deem high qualiti repres near univers ortholog gene eudicot clade near transcript function annot use combin three approach current studi focus describ coniin pathway identifi silico transcript candid polyketid reductas l alanin keto octan aminotransferas conicein reductas adenosyl l methionin coniin methyltransferas vitro test need confirm assign function select candid
|
D029982;D000470
|
T123;T121;T109;T131;T002
|
36,266,298
|
technolog readi level machin learn system develop deploy machin learn system execut easili modern tool process typic rush mean end lack dilig lead technic debt scope creep misalign object model misus failur expens consequ engin system hand follow well defin process test standard streamlin develop high qualiti reliabl result extrem spacecraft system mission critic measur robust throughout process draw experi spacecraft engin machin learn research product across domain area develop proven system engin approach machin learn artifici intellig machin learn technolog readi level framework defin principl process ensur robust reliabl respons system streamlin machin learn workflow includ key distinct tradit softwar engin lingua franca peopl across team organ work collabor machin learn artifici intellig technolog describ framework elucid use case physic research comput vision app medic diagnost
|
D001185;D000069550
|
T090;T073;T066
|
36,266,296
|
fractur relat infect musculoskelet trauma lead broken damag bone soft tissu life threat event modern orthopaed trauma surgeri combin innov medic devic allow mani sever injuri rapid repair eventu heal unfortun one persist complic fractur relat infect fri case pathogen bacteria enter wound divert host respons bone heal cours inflammatori antibacteri cours prevent bone heal fri lead perman disabl long cours therapi last month year past year intern consensus definit infect focus greater attent fri new guidelin avail prevent diagnosi treatment improv understand role periop antibiot prophylaxi optim treatment approach would transform field basic scienc engin innov requir reduc infect rate intervent effici deliveri antibiot new antimicrobi optim host defenc among like improv care patient fri
|
D013530;D050723
|
T046;T037
|
36,266,295
|
automat hypothesi generat plausibl linkag xanthium diabet signific increas text mine implement biomed literatur recent year previous studi introduc implement text mine literatur base discoveri generat hypothes potenti candid drug develop conduct hypothesi generat step use evid publish journal articl proceed previous studi manag reduc experiment time cost first appli close discoveri approach swanson abc model collect public relat xanthium compound diabet second extract biomed entiti relat use knowledg extract engin public knowledg discoveri engin java pkdej third built knowledg graph use obtain bio entiti relat generat path xanthium compound sourc node diabet target node last employ graph embed rank path evalu result base domain expert opinion literatur among xanthium compound direct path five diabet relat node rank path total xanthium compound three diabet relat phrase type diabet type diabet diabet mellitus base top five percentil path conclud adenosin cholin beta sitosterol rhamnos scopoletin potenti candid diabet drug develop use natur product framework hypothesi generat employ close discoveri swanson abc model proven help discov biolog linkag bio entiti pkdej tool use captur bio entiti document collect could label entiti five categori gene compound phenotyp biolog process molecular function use bioprep model manag interpret semant related two node provid path contain valuabl hypothes last use graph embed algorithm path rank analysi exploit semant related preserv graph structur properti
|
D031210;D003924;D001688
|
T123;T047;T121;T002
|
36,266,293
|
model aquif storag recoveri eastern district unit arab emir use modflow emir abu dhabi reli groundwat sourc fresh water sever decad result deterior non renew groundwat aquif led instal desalin plant fresh water suppli research aim increas strateg water reserv eastern district abu dhabi analyz best locat aquif storag recoveri asr asr technolog offer opportun store larg volum water later benefici use studi explor option use excess desalin water asr recharg eastern district al region abu dhabi limit factor applic asr technolog lack suitabl site detail hydrogeolog oper knowledg studi area help identifi potenti site asr base score system determin best locat manag aquif recharg crucial design step five scenario studi al khrair al shuwaib site al region result show wider distribut inject well interv suitabl overcom excess head buildup base adopt criteria al khrair best site recharg follow al shuwaib al khrair site recharg seven year al shuwaib site recharg two year
|
D060587
|
T081;T070;T082
|
36,266,292
|
quantit proteom analysi microbi degrad aminobenzo acid comamona sp qt mab cluster associ aminobenzo acid ab degrad identifi comamona sp qt howev cellular respons comamona sp qt aminobenzo acid remain unclear studi label free quantit proteom analysi base lc msms use studi protein express differ strain qt condit use ab ab citric acidammonium chlorid substrat abcon total protein identifi signific regul ab group signific regul ab group express ab group express abcon group ab group kegg pathway analysi found pathway regul pathway regul go analysi path regul path regul gene mab cluster detect ab groupth mab cluster found relat degrad ab knockout found growth rate mutant orf orf slow hplc result show mutant orf orf could still degrad ab found orf orf key gene ab degrad could replac gene strain qt find improv understand molecular mechan under cellular respons ab degrad comamona bacterium
|
D020585
|
T007
|
36,266,291
|
immun signatur data resourc compendium system vaccinolog dataset vaccin among cost effect public health intervent prevent infect induc morbid mortal yet much remain learn regard mechan vaccin protect system immunolog combin tradit immunolog modern omic profil techniqu comput model promot rapid transform advanc vaccinolog vaccin discoveri nihniaid human immunolog project consortium hipc leverag system immunolog approach identifi molecular signatur associ immunogen mani vaccin howev compar analys limit distribut natur data potenti batch effect across studi absenc multipl relev studi non hipc group immport support compar analys across differ vaccin creat immun signatur data resourc compendium standard system vaccinolog dataset data resourc avail immunespac along code reproduc process batch normal start under studi data immport gene express omnibus geo current releas compris particip cohort profil respons differ vaccin novel system vaccinolog data releas repres valuabl resourc compar meta analys acceler understand mechan under vaccin respons
|
D014612;D000078782
|
T129;T121;T091;T116
|
36,266,288
|
hemispher specif spatial represent hippocamp granul cell dentat gyrus dg output play key role emerg spatial contextu map represent within hippocampus learn differ neuron network activ observ left right ca area impli later spatial code properti whether bilater differ dg granul cell gc assembl encod spatial contextu inform exist remain larg unexplor employ two photon calcium imag left right dg record activ gc popul five consecut day head fix mice navig familiar novel virtual environ imag reveal similar mean gc activ side howev spatial tune context select run run place field reliabl mark higher dg place cell left right hemispher moreov proport gcs reconfigur place field context greater left dg thus data suggest contextu inform differenti process gc popul depend hemispher higher context discrimin left bias toward general right dg
|
D018891;D000071037
|
T023;T025
|
36,266,287
|
cross link endolysosom system reveal potenti flotillin structur cargo lysosom well establish main cellular organell degrad macromolecul emerg regulatori center metabol crucial import cellular homeostasi exemplifi plethora disord relat alter lysosom function context protein complex play decis role regul metabol lysosom process also lysosom biogenesi transport interact organell use cross link mass spectrometri analyz lysosom earli endosom base identif cross link investig protein protein interact structur lysosom endosom relat protein particular present evid tetramer assembl lysosom hydrolas ppt heterodimer structur flotflot lysosom earli endosom flot flot posit earli endosom identifi putat cargo protein confirm eleven substrat flotillin depend endocytosi includ latrophilin famili adhes g protein coupl receptor
|
D011992;D008247
|
T026
|
36,266,286
|
p mutat normal esophagus promot multipl stage carcinogenesi constrain clonal competit age normal human oesophagus accumul tp mutant clone origin oesophag squamous carcinoma biallel tp disrupt almost univers howev p mutant clone expand contribut cancer develop unclear show induc p rw mutant singl oesophag progenitor cell transgen mice confer prolif advantag clonal expans disrupt normal epitheli structur loss remain p allel mutant cell result genom unstabl p rwnull epithelium giant polyaneuploid cell copi number alter clone carcinogenesi p mutat initi tumour format tumour develop area p mutat loh larger show extens chromosom instabl compar lesion aris wild type epithelium conclud p distinct function differ stage carcinogenesi loh within p mutant clone normal epithelium critic step malign transform
|
D016159;D063646
|
T123;T191;T116
|
36,266,285
|
epidem spread mutual independ intra inter host pathogen evolut dynam epidem spread often reduc singl control paramet r reproduct rate whose valu uniti determin state contagion howev pathogen evolv spread r may chang time potenti lead mutat driven spread initi sub pandem pathogen undergo breakthrough mutat predict boundari pandem phase introduc model framework coupl inter host network spread pattern intra host evolutionari dynam find even extrem case two process driven mutual independ select forc mutat still fundament alter pandem phase diagram pandem transit show shape r also balanc epidem evolutionari timescal mutat slow pathogen preval decay prior appear critic mutat hand mutat rapid pathogen evolut becom volatil fail spread two extrem howev identifi broad rang condit initi sub pandem pathogen breakthrough gain widespread preval
|
D058872
|
T067
|
36,266,284
|
incorpor social knowledg structur comput model navig social interact success human need continu learn person trait peopl eg help aggress person howev formal model captur complex social learn process current lack studi specifi test potenti strategi human employ learn other standard rescorla wagner rw learn model captur part learn process neglect inher knowledg structur omit previous acquir knowledg therefor formal two social knowledg structur implement hybrid rw model test use across multipl social learn task name concept granular knowledg structur person trait util differ level detail learn refer point previous knowledg formal represent averag peopl within social group five behaviour experi result model comparison statist analys indic particip effici combin concept granular refer point specif combin model depend peopl trait particip learn overal experi demonstr variant rw algorithm incorpor social knowledg structur describ crucial aspect dynam play peopl interact
|
D007858;D000465
|
T062;T170;T041;T061
|
36,266,283
|
forc trigger rapid microstructur growth hydrogel surfac demand function live organ share abil grow various microstructur surfac achiev function present forc stamp method grow microstructur surfac hydrogel base forc trigger polymeris mechan doubl network hydrogel method allow fast spatial modul morpholog chemistri hydrogel surfac within second demand function demonstr orient growth cell direct transport water droplet engin hydrogel surfac forc trigger method chemic engin hydrogel surfac provid new tool addit convent method use light heat promot wide applic hydrogel various field
|
D020100;D014867
|
T121;T122;T197
|
36,266,281
|
viral transduct primari human lymphoma b cell reveal mechan notch mediat immun escap hotspot mutat pest domain notch notch recurr identifi b cell malign address notch mutat contribut dismal prognosi generat isogen primari human tumor cell patient chronic lymphocyt leukemia cll mantl cell lymphoma mcl differ express intracellular domain icd notch notch data demonstr notch paralog facilit immun escap malign b cell regul pd l part depend autocrin interferon signal addit notch activ caus silenc entir hla class ii locus via epigenet regul transcript co activ ciita notabl notch notch govern similar transcript program diseas specif differ express level favor paralog specif select import notch icd also strong regul express cd possibl limit effect immun therapi notch mediat immun escap mechan associ expans exhaust cd cell vivo
|
D051881;D008223
|
T191;T116;T192
|
36,266,280
|
genom insight physiolog quinella icon uncultur rumen bacterium quinella genus icon rumen bacteria first report cultur bacteria inform physiolog scarc contradictori increas abund quinella previous found rumen sheep emit low amount methan ch relat feed intak whether quinella contribut low ch emiss known concentr quinella cell sheep rumen content extract sequenc dna reconstruct quinella genom complet littl contamin bioinformat analys encod protein indic lactat propion format major ferment pathway presenc gene encod potenti uptak hydrogenas suggest quinella might abl use free hydrogen h none infer metabol pathway predict produc h major precursor ch consist lower ch emiss sheep high abund bacterium
|
D012417;D011422
|
T121;T023;T109
|
36,266,278
|
salivari microbiom show high preval core bacteri member yet variabl across human popul human saliva contain divers bacteri communiti reflect health status dietari pattern contribut variabl sensori percept food mani descript divers salivari microbiom focus chang induc certain diseas state common differ within healthi saliva fulli describ defin explor core membership human salivari microbi communiti collect analys raw rrna amplicon sequenc data studi saliva sampl found core bacteri taxa consist detect differ induc various host intrins behaviour factor includ gender age geograph locat tobacco usag alcohol consumpt evid core salivari microbiom verifi collect analys saliva independ studi result suggest method use effect defin core microbi communiti human saliva core salivari microbiom demonstr stabil variabl among popul geograph locat identifi host factor associ structur salivari microbiota independ analysi confirm preval core otus defin global data provid inform bacteri taxa saliva vari across human popul
|
D064307
|
T001;T032;T028
|
36,266,277
|
role mucus bacteria interact enterotoxigen escherichia coli etec h virul interplay human microbiom intestin mucus layer dual role human health constitut well known microbi nich support gut microbiota mainten also act physic barrier enter pathogen enterotoxigen escherichia coli etec major agent respons travel diarrhea abl bind degrad intestin mucin repres import understudi virul trait pathogen use set complementari vitro approach simul human digest environ studi aim describ mucus microenviron could shape differ aspect human etec strain h pathophysiolog name surviv adhes virul gene express interleukin induct interact human fecal microbiota use tno gastrointestin model tim simul physicochem condit human upper gastrointestin gi tract report mucus secret physic surfac sustain etec surviv probabl help face gi stress integr host part cacoht mtx co cultur model demonstr mucus secret cell favor etec adhes virul gene express imped etec interleukin il induct furthermor prove mucos surfac favor etec colon complex gut microbi background simul batch fecal experi howev mucus specif microbiota wide modifi upon etec challeng suggest role pathogen infecti cycl use multi target vitro approach studi support major role play mucus etec pathophysiolog open avenu design new treatment strategi
|
D054307;D004927;D064307
|
T032;T007;T028;T047;T001
|
36,266,276
|
promiscu respons regul thioredoxin steer bacteri virul exquisit specif sensor kinas cognat respons regul ensur faith partner select within two compon pair concurr fire singl bacterium minim crosstalk member conserv famili paralog protein show conserv hydrophob charg residu surfac thioredoxin serv dock station structur divers respons regul use ompr protein identifi residu flexibl linker c termin hairpin enabl associ archetyp respons regul thioredoxin dispens interact transcript factor cognat sensor kinas envz dna rna polymeras show promiscu interact respons regul thioredoxin foster flow inform otherwis high dedic two compon signal system therebi enabl transcript salmonella pathogen island gene well growth intracellular bacterium macrophag mice
|
D001426;D029968
|
T123;T116
|
36,266,275
|
combin mass spectrometri machin learn discov bioactiv peptid peptid play import role regul biolog process form basi multipl therapeut drug date peptid human confirm bioactiv although ten thousand report literatur major inact degrad product endogen protein peptid present needl haystack problem identifi promis candid peptid larg scale peptidom experi test bioactiv address challeng conduct comprehens analysi mammalian peptidom across seven tissu four differ mous strain use data train machin learn model predict hundr peptid candid base pattern mass spectrometri data provid silico valid exampl experiment confirm bioactiv two peptid demonstr util resourc discov lead peptid character therapeut develop
|
D010455;D000069550
|
T121;T116;T066
|
36,266,274
|
bdnf trkb autocrin loop enhanc senesc cell viabil cellular senesc character cell cycl arrest resist apoptosi senesc associ secretori phenotyp sasp wherebi cell secret pro inflammatori tissu remodel factor given sasp exacerb age associ patholog age intervent aim select elimin senesc cell studi drug librari screen uncov trkb ntrk inhibitor capabl trigger apoptosi sever senesc prolifer human cell senesc cell express high level trkb support senesc cell viabil secret trkb ligand bdnf reduc viabil senesc cell ablat bdnf signal suggest autocrin function trkb bdnf activ erk elev bcll level favor senesc cell surviv treatment trkb inhibitor reduc accumul senesc cell age mous organ propos activ trkb sasp factor bdnf promot cell surviv could exploit therapeut reduc senesc cell burden
|
D019208;D016922
|
T123;T116;T043
|
36,266,273
|
cryogen contrast enhanc microct enabl nondestruct quantit histopatholog soft biolog tissu biolog tissu compris spatial complex structur composit organ microscal name microstructur given close structur function relationship tissu structur character essenti fulli understand function healthi patholog tissu well impact possibl treatment present nondestruct imag approach perform quantit histo patho logi biolog tissu term cryogen contrast enhanc microct cryo cect combin sampl stain use x ray contrast enhanc stain agent freez sampl optim freez rate cryo cect enabl visual structur analysi individu tissu constitu muscl collagen fiber appli cryo cect murin heart subject pressur overload follow transvers aortic constrict surgeri cryo cect allow analyz unpreced manner orient diamet individu muscl fiber entir heart well local fibrot region within myocardi layer forese applic cryo cect optim tissuefood preserv donor bank show cryo cect also clinic industri potenti
|
D009141
|
T022
|
36,266,272
|
proteogenom refin molecular classif chronic lymphocyt leukemia cancer heterogen proteom level may explain differ therapi respons prognosi beyond current establish genom transcriptom base diagnost relev proteom diseas classif remain establish clinic heterogen cancer entiti chronic lymphocyt leukemia cll character proteom transcriptom alongsid genet ex vivo drug respons profil clinic annot cll discoveri cohort n unsupervis cluster proteom data reveal six subgroup five proteom group associ genet featur one group detect proteom level new group character acceler diseas progress high spliceosom protein abund associ aberr splice low b cell receptor signal protein abund asb cll classifi develop identifi asb cll base characterist proteom splice signatur two independ cohort n n confirm asb cll compris cll patient inferior overal surviv asb cll also independ tp ighv mutat status multi omic analysi refin classif cll highlight potenti proteom improv cancer patient stratif beyond genet transcriptom profil
|
D015451;D000071696
|
T191;T091
|
36,266,270
|
system biolog analysi rheumatoid arthriti fibroblast like synoviocyt implic cell line specif transcript factor function rheumatoid arthriti ra immun mediat diseas affect diarthrodi joint remain unmet medic need despit improv therapi limit like reflect divers pathogen pathway ra individu patient demonstr variabl respons target therapi better understand ra pathogenesi would aid complet character diseas tackl challeng develop appli system biolog approach identifi import transcript factor tfs individu ra fibroblast like synoviocyt fls cell line integr transcriptom epigenom inform base relat import identifi tfs stratifi ra fls cell line two subtyp distinct phenotyp predict activ pathway biolog valid predict top subtyp specif tf rar demonstr differenti regul tgf signal two subtyp studi character cluster ra cell line distinct tf biolog integr transcriptom epigenom data could pave way toward greater understand diseas heterogen
|
D000070918;D001172
|
T047;T025
|
36,266,267
|
high fat diet induc cyclophilin b enhanc statlncrna pvt feedforward loop promot growth metastasi colorect cancer high fat diet hfd implic promot colorect cancer crc recent oncogen cyclophilin b cypb report induc cholesterol howev role cypb crc carcinogenesi metastasi associ hfd remain unknown present studi show hfd induc cypb enhanc prolifer metastasi inflamm driven circuit includ signal transduc activ transcript stat trigger transcript lncrna pvt bind cypb promot activ stat cypb found upregul crc correl elev bodi mass index poor prognosi hfd induc cypb express proinflammatori cytokin colon mice besid cypb restor facilit growth invas metastasi crc cell vitro vivo moreov rip sequenc data identifi lncrna pvt function bind partner cypb mechanist pvt increas phosphoryl nuclear transloc stat respons il direct interact cypb imped bind suppressor cytokin signal soc stat furthermor stat turn activ pvt transcript bind promot form regulatori loop final cypbstatpvt axi verifi tcga dataset crc tissu array data reveal cypb link hfd crc malign enhanc cypbstatpvt feedforward axi activ stat
|
D015179;D062085
|
T123;T191;T114
|
36,266,266
|
zymosan promot regener intestin stem cell upregul ascl intestin stem cell isc respons intestin tissu homeostasi import regener damag intestin epithelia establish ioniz radiat ir induc intestin injuri model found tlr agonist zymosan promot regener isc vivo vitro zymosan improv surviv abdomin irradi mice mice treat group vs mice pbs group inhibit radiat damag intestin tissu increas surviv rate intestin crypt number isc lethal ir vivo organoid experi found zymosan promot prolifer differenti isc ir remark result rna sequenc western blot wb show zymosan reduc ir induc intestin injuri via tlr signal pathway wnt signal pathway zymosan radioprotect tlr ko mice suggest zymosan may play radioprotect role target tlr moreov result reveal zymosan increas ascl transcript factor isc play core role process zymosan ir induc intestin injuri like contribut surviv intestin organoid post radiat conclus demonstr zymosan promot regener isc upregul ascl
|
D013234;D051195
|
T081;T116;T025;T192
|
36,266,264
|
non enzymat role sod intestin stem cell growth superoxid dismutas sod modul intestin barrier integr intestin homeostasi antioxid enzym intestin homeostasi maintain intestin stem cell isc howev whether sod regul isc unknown studi establish intestin organoid tamoxifen induc intestin epitheli cell specif sod knockout sod ff vil creert mice found loss sod organoid suppress prolifer surviv cell lgr gene express sod known near half centuri canon role antioxid enzym identifi enzym independ function isc inhibit sod enzymat activ impact organoid growth enzymat inact sod mutant could complet rescu growth defect sod defici organoid suggest sod mediat isc growth independ enzymat activ moreov sod defici affect ros level organoid induc elev wnt signal excess paneth cell differenti mediat occurr growth defect sod defici organoid vivo epitheli sod loss induc higher incid apoptosi stem cell region increas paneth cell number accompani enhanc express egfr ligand epiregulin ereg stromal tissu may compens sod loss maintain intestin structur vivo total result show novel enzym independ function sod isc growth homeostasi
|
D013482;D007414
|
T121;T191;T126;T116
|
36,266,263
|
valid multi frequenc bioelectr imped analysi devic assess bodi composit older adult type diabet age type diabet tdm associ increas risk sarcopenia diagnosi sarcopenia common done use dual energi x ray absorptiometri dxa special set anoth avail method assess bodi composit direct segment multi frequenc bioelectr imped analysi dsmf bia examin accuraci dsmf bia inbodi assess bodi composit older adult tdm compar dxa
|
D055948;D003924
|
T047
|
36,266,241
|
photoinduc ion pair inner sphere electron transfer revers addit fragment chain transfer polymer photoredox mediat revers deactiv radic polymer rdrp promis method precis synthesi polym divers structur properti howev mechan main base outer sphere electron transfer oset lead stringent requir effici photocatalyst paper zwitterion organoboran l b x prepar appli revers addit fragment chain transfer raft polymer photoinduc ion pair inner sphere electron transfer ip iset mechan ion pair electron transfer mechan format radic l b support electron paramagnet reson epr radic captur experi h b nmr spectroscopi spectroelectrochem spectroscopi transient absorpt spectroscopi theoret calcul photoluminesc quench experi photoluminesc quench experi show cta l b static quench situ format l b zcs real catalyt speci l b c h scs synthes photoluminesc lifetim lifetim static quench experi indic format l b zcs polymer ip iset mechan matrix assist laser desorpt ionize time flight mass maldi tof ms spectra show structur c h scs incorpor polym indic ion pair electron transfer occur catalyt speci polymer show high catalyt activ ppb catalyst load wide rang monom excel toler presenc mol phenol inhibitor synthesi ultrahigh molecular weight polym protocol ip iset mechan exhibit valu develop new organ transform polymer method
|
D004583;D011108
|
T081;T104;T196;T122
|
36,266,240
|
editori acceler epigenet age consequ earli environment advers editori discuss find implic hypothesi generat studi copeland colleagu show earli advers event relat unpredict well cumul score summaris environment advers childhood adolesc link acceler epigenet age set studi longitudin great smoki mountain studi rich phenotyp longitudin cohort biolog inform discuss focus potenti mechan behind report find opportun next step exampl provid rich data cohort use studi
|
D044127;D000375
|
T033;T045;T040
|
36,266,192
|
irrevers electropor electrochemotherapi oncolog state art thermal tumor ablat techniqu includ radiofrequ microwav laser high intens focus ultrasound cryoablat routin use treat liver kidney bone lung tumor howev techniqu thermal therefor affect heat sink effect lead incomplet ablat thermal injuri non target tissu possibl certain condit high voltag puls electr field induc format pore cell membran phenomenon call electropermeabil also known electropor certain condit electropor irrevers lead cell death irrevers electropor demonstr efficaci treatment liver prostat cancer wherea data scarc regard pancreat renal cancer revers electropor transient cell permeabl use introduc cytotox drug tumor cell common bleomycin cisplatin revers electropor use conjunct cytotox drug show promis term oncolog respons particular solid cutan subcutan tumor melanoma irrevers revers electropor thermal ablat techniqu therefor open new promis horizon tumor ablat
|
D053672;D009369;D000970
|
T061;T121;T191;T109
|
36,266,185
|
conserv intervent effect other peopl chronic non specif neck pain systemat review network meta analysi effect conserv intervent patient non specif chronic neck pain cnsnp
|
D059350;D026201
|
T061;T184;T047
|
36,266,164
|
cortisol cardiometabol diseas target advanc health equiti stress intrins psychosoci extrins physic environment form impact develop outcom cardiovascular diseas cvd allostat load cortisol core hormon mediat allostat load produc respons various stress alter morn serum cortisol daili diurnal cortisol associ adipos dyslipidemia incid diabet cvds hypertens review examin role cortisol key mechanist link stress physiolog cardiometabol diseas import discuss role target cortisol pharmacolog behavior environment intervent advanc health equiti cardiometabol diseas
|
D000069576;D006973;D002318
|
T047;T080
|
36,266,129
|
molecular surveil rubella virus beij china progress challeng rubella elimin rubella list world health organ diseas need elimin worldwid aim studi understand progress challeng toward rubella elimin beij china analyz molecular surveil data combin immun surveil strategi well epidemiolog data high immun coverag dose polici month month year supplementari immun activ float popul rubella incid show downward trend sinc despit two epidem occur report rubella case general concentr age group year although citywid surveil congenit rubella syndrom crs carri sinc one case confirm laboratori test furthermor molecular surveil data show rubella virus rvs circul beij evid heterogen domest lineag e l multipl import lineag includ b l e l b lc identifi last decad meanwhil two lineag relat switch determin includ displac lineag e l lineag b l around transit lineag b l lineag e l b lc rv transmiss pattern similar observ across countri wherea lineag e l b lc preval beij shorter period overal result indic need maintain routin immun rubella contain vaccin promot regular supplementaryimmunizationact enhanc rubella crs surveil even order acceler rubella elimin beij exist immun strategi must optim close immun gap
|
D012409;D012410
|
T047
|
36,266,127
|
covid vaccin literaci vaccin hesit among pregnant women mother young children japan delay spread vaccin recogn urgent public health issu context covid pandem vaccin literaci vl critic determin vaccin uptak howev littl known vl among pregnant women mother young children
|
D000086382;D014612
|
T129;T121;T116;T067;T047
|
36,266,085
|
research progress polyetheretherketon composit field dental implant polyetheretherketon peek polym materi compos aromat ring connect ether keton group advantag excel biocompat stabl chemic properti appropri elast modulus sinc peek increas use dentistri recent year properti modif method research advanc oral implantolog discuss review
|
D015921
|
T074
|
36,266,084
|
research advanc use dynam navig technolog implant edentul jaw use dynam navig technolog edentul jaw implant restor solv mani problem associ tradit edentul jaw implant restor benefit dynam navig includ fine posit guidanc restor guid surgeri good aesthet result possibl simultan conceptu design real time implant guidanc well transit blind direct vision implant guid clinician adjust plan real time improv effici communic clinician technician patient throughout process workflow current clinic applic challeng accuraci analysi limit dynam navig technolog edentul jaw discuss paper well outlook futur develop goal contribut clinic develop dynam navig guid implantolog edentul jaw
|
D015921;D025321;D007575
|
T061;T047;T074
|
36,266,083
|
mendelian random applic periodont mendelian random causal infer method use genet variat instrument variabl skill take advantag distribut random time prioriti genet variat effect avoid confound bias revers causal tradit observ research becom research hotspot recent year complex inflammatori diseas periodont associ mani factor cognit associ most base tradit observ studi lack strong evid infer causal order bring new research idea periodont field articl main review mendelian random research progress periodont
|
D057182;D010518
|
T062;T047
|
36,266,082
|
root canal therapi maxillari first molar seven root canal case report ct
|
D003786;D008963
|
T023;T030
|
36,266,081
|
oral lichen sclerosus et atrophicus case report lichen sclerosus et atrophicuslsalsa
|
D018459
|
T047
|
36,266,080
|
construct patholog character anim model temporomandibular joint degen joint diseas mice object explor patholog characterist three mice model temporomandibular joint degen joint diseas tmjdjd includ osteoarthr osteoarthrosi provid refer anim experiment studi regard patholog mechan osteoarthr osteoarthrosi method total week old male cbl mice select construct three tmjdjd anim model includ bilater temporomandibular joint tmj freund complet adjuv fca inject model bilater tmj monosodium iodoacet mia inject model right tmj discectomi model fca inject model mice divid salin inject group fca inject group week fca inject group week fca inject group week fca inject group week mice use time point total tmjs side mia inject model mice separ salin inject group mia inject group week mia inject group week mia inject group week mia inject group week mice use time point total tmjs side tmj discectomi model mice split control group discectomi group week group discectomi group week discectomi group week six mice use time point total six right tmjs general pictur bilater joint area mice collect day drug inject stereoscop imag condylar tissu collect week microsurgeri discectomi mous tmj tissu section time point stain toluidin blue respect synovi tissu score synovi inflamm percentag proteoglycan condylar cartilag quantit analyz result one day intra articular fca mia inject width bilater tmj signific increas fca inject group mm compar salin inject group mm p width bilater tmj mia inject group mm also signific higher salin inject group mm p synov score fca inject group week fca inject signific higher salin inject group f p proteoglycan condylar cartilag increas first decreas compar salin inject group f p condylar cartilag proteoglycan loss differ degre observ week mia inject f p synov score increas differ degre compar salin inject group f p morpholog condylar cartilag discectomi group mice sever damag synovi tissu show dens connect tissu lesion week postop condylar cartilag tissu show time depend loss proteoglycan compar control group f p conclus intra articular fca inject establish mous model tmj osteoarthr sever synovi inflamm intra articular mia inject construct mous model typic tmj osteoarthr discectomi establish mous tmj osteoarthrosi model sever condylar cartilag destruct
|
D002358;D010003;D013585
|
T047;T024
|
36,266,079
|
role brain muscl arnt like protein rat periodont induc liver injuri model object brain muscl arnt like protein bmal core compon hepatocyt molecular clock play import role regul relat rhythmic gene bodi transcript translat feedback loop molecular circadian oscil therefor aim studi investig role bmal rat periodont induc liver injuri method twelv male wistar rat divid control group periodont group accord random number tabl method rat control group untreat periodont model establish ligat neck bilater maxillari first molar periodont group rat week periodont clinic index rat group examin execut micro ct scan maxilla perform level alveolar bone resorpt analyz patholog chang periodont liver tissu rat two group detect oil red stain biochem kit use detect glutam oxaloacet transaminas got glutam pyruv transaminas gpt total cholesterol tc triglycerid tg serum gene protein express level bmal nuclear factor kappa b nf b tumor necrosi factor tnf liver tissu measur real time fluoresc quantit pcr qrt pcr immunohistochemistri ihc western blot wb assay apoptosi detect liver tissu termin deoxynucleotidyl transferas mediat dutp biotin nick end label tunel kit stain result result stain maxillari first molar micro ct result maxillari bone show alveolar bone resorpt signific periodont group rat liver histopatholog result show infiltr inflammatori cell liver tissu disorgan liver cord larg number lipid droplet form hepatocyt periodont group compar control group result serum biochem assay show level got ul gpt ul tc mmoll tg mmoll serum rat periodont signific higher control group respect got ul gpt ul tc mmoll tg mmoll p p p p qrt pcr result show mrna express level bmal signific decreas liver tissu periodont group compar control group p mrna express level nf b tnf signific increas compar control group p p ihc result show protein express level bmal liver tissu periodont group averag optic densiti aod regul compar control group aod p nf b tnf aod regul compar control group aod p p wb result show protein express level bmal liver tissu regul periodont group compar control group p nf b tnf regul compar control group p p tunel stain show increas apoptot cell liver tissu periodont group rat compar control group conclus periodont may induc liver injuri regul bmal express level liver tissu turn activ nf b signal molecul lead elev level inflamm apoptosi rat liver
|
D001862;D056487;D010518
|
T047;T042
|
36,266,078
|
year retrospect studi comput aid design comput aid manufactur ceram endocrown endodont treat posterior teeth object evalu clinic outcom comput aid design comput aid manufactur cadcam ceram endocrown endodont treat posterior teeth five year retrospect studi method patient receiv cadcam ceram endocrown endodont treatment depart endodont school stomatolog fourth militari medic univers januari june invit clinic studi clinic perform evalu aspect color match anatom form margin adapt restor integr secondari cari surviv rate restor calcul use kaplan meier method log rank test appli well sake analyz effect tooth posit sex materi surviv rate restor result seventi four patient men women age year particip studi total cadcam ceram endocrown observ period month fail case among restor loss retent ceram fractur secondari cari respect particular restor got score anatom form restor got score margin adapt restor show good color match compar abut teeth estim cumul surviv rate cadcam ceram endocrown endodont treat posterior teeth year ci singl factor log rank analysi demonstr statist signific differ surviv rate cadcam ceram endocrown among men women premolar molar posit dental arch differ materi p p p p conclus base clinic studi clinic perform cadcam ceram endocrown endodont treat posterior teeth five year reliabl could general option restor nonvit teeth
|
D003442;D003776
|
T122;T074
|
36,266,077
|
trueness three dimension facial scanner vitro studi object investig trueness three dimension facial scanner evalu applic clinic use method art head model use scan object scan handyscan scanner enclos environ fix light sourc obtain refer digit model three fix facial scanner dmdface b facego pro c rds facescan portabl hand held facial scanner revopoint pop use scan art head model time model scan group obtain face refer model divid region accord anatomi muscl distribut geomag wrap softwar save boundari curv whole face region test model also divid region curv regist refer model best fit function root mean squar error rms complet test model segment region compar refer model correspond region calcul comparison function smaller rms higher accuraci one way anova snk post test use statist analysi result rms complet test model scan b c scanner mm f p respect signific differ two group p facial region group best trueness nasal region lip region left orbit region right orbit region rms mm respect group c best trueness frontal region left buccal region right buccal region left zygomat region right zygomat region left parotideomasseter region right parotideomasseter region left temporofaci region right temporofaci region mental region left infraorbit region right infraorbit region rms mm respect conclus basi art head model scan although overal averag deviat scan model refer model obtain four kind facial scanner small portabl handheld facial scanner better accuraci fix facial scanner b c orbit area nasal area lip area area rich featur
|
D017076;D021621
|
T062;T060;T073;T066
|
36,266,076
|
virtual reconstruct clinic verif maxillari defect base deep learn object construct virtual reconstruct method includ midspan maxillari defect provid clinic refer train generat adversari network gan model method ct data middl age han patient oral diseas visit depart radiolog west china hospit stomatolog sichuan univers june june collect ct data healthi maxilla maxillari defect simpl unilater defect unilater defect involv zygomat bone midspan defect select mimic use creat spheric phantom simul bone defect around healthi maxilla includ simpl unilater defect unilater defect involv zygomat bone midspan defect origin imag set correct refer reconstruct artifici defect pair correct refer divid train set n valid set n test set n first two use train gan model test set use evalu gan perform data clinic defect import train gan model reconstruct mirror gan base virtual reconstruct unilater clinic defect latter method adopt midspan defect reconstruct result divid mirror reconstruct group n unilater defect gan reconstruct group n midspan defect gan reconstruct group n test set mirror reconstruct group unilater defect gan reconstruct group quantit evalu whose quantit indic dice similar coeffici dsc hausdorff distanc hd group result subject one way anova tukey test test set mirror reconstruct group unilater defect gan reconstruct group midspan defect gan reconstruct group qualit score kruskal walli test bonferroni correct use total score group result total differ test set mirror reconstruct group unilater defect gan reconstruct group dcs respect hd mm respect statist signific f p f p among test set dsc signific larger mirror reconstruct group p test set hd signific less mirror reconstruct group p overal differ qualit total score point respect test set mirror reconstruct group unilater defect gan reconstruct group midspan defect gan reconstruct group statist signific h p pairwis comparison show total score test set signific higher mirror reconstruct group p conclus virtual reconstruct method base gan propos studi better virtual reconstruct effect unilater defect mirror techniqu also realiz virtual reconstruct maxillari midspan defect
|
D008437;D000077321
|
T023;T066
|
36,266,075
|
preliminari clinic effect evalu digit head neck radiotherapi oral posit stent object develop design softwar digit oral posit stent radiotherapi head neck compar clinic effect tradit oral posit stent made lost wax process method thirti patient nasopharyng cancer receiv oral examin radiotherapi prosthodont depart juli decemb select divid three group accord patient wish per group one group without radiotherapi oral posit stent one group tradit oral posit stent tradit stent group third group digit oral posit stent digit stent group patient age rang year old year old male femal involv studi manufactur time comfort two posit stent evalu radiat dose radiotherapi target area surround healthi tissu statist analyz end radiotherapi result manufactur time digit stent group min much less tradit stent group min p comfort patient wear digit stent first wear score end radiotherapi score better tradit one first wear score end radiotherapi score u p u p signific differ target radiat dose among three group radiat dose tongu tradit stent group gy digit stent group gy mandibl tradit stent group gy digit stent group gy signific lower patient wear oral posit stent patient without oral posit stent tongu gy madibl gy p conclus oral posit stent nasopharyng carcinoma radiotherapi could great reduc exposur dose tongu madibl patient digit oral posit stent design manufactur independ develop softwar higher product effici tradit method patient evalu comfort better
|
D009303;D006258
|
T191
|
36,266,074
|
preliminari measur analysi condylar movement envelop surfac paramet healthi adult object measur analyz paramet three dimension model condylar movement envelop surfac es provid refer design temporomandibular prosthesi method thirti four healthi adult age year recruit depart oral maxillofaci surgeri peke univers school hospit stomatolog subject male femal univers student other outsid univers receiv undergradu educ condylar movement es obtain use previous method trajectori condyl simul condylar movement project accord open movement protrus movement later movement respect total area es area proport model form differ mandibular movement measur calcul adult head maxillofaci model reconstruct cone beam ct regist es geomag studio inner outer pole condyl correct sagitt axi es median sagitt plane msp calibr registr model use geomag studio paramet measur follow anteroposterior medialater diamet condyl anteroposterior diamet transvers diamet anterior middl posterior part es angl correct sagitt axi es msp es msp pearson correl analysi perform spss result total area es mm open movement part account protrus movement part account later movement part account paramet measur follow mediolater diamet condyl mm anteroposterior diamet es mm transvers diamet anterior middl posterior part es mm respect transvers diamet es mm larger condyl angl correct sagitt axi es msp coeffici variat cv paramet show cv transvers diamet anterior middl posterior part es mediolater diamet condyl respect p cv aera es mediolater diamet condyl p cv aera es anteroposterior diamet es p conclus envelop surfac model form mandibular open movement account largest proport es correct sagitt axi es angl msp transvers diamet anterior middl posterior part es approxim mm larger mediolater diamet condyl transvers diamet anterior middl posterior part es high posit correl mediolater diamet condyl
|
D008335;D054893
|
T060;T023
|
36,266,073
|
applic digit technolog esthet function rehabilit sever worn dentit sever worn dentit serious affect patient esthet function etiolog complex differenti diagnosi difficult treatment process involv multipl disciplin requir esthet function rehabilit step sequenti treatment rehabilit sever worn dentit establish recent year digit technolog increas appli esthet function rehabilit sever worn dentit articl describ applic digit method step sequenti treatment sever worn dentit
|
D057085
|
T037
|
36,266,072
|
digit integr strategi simultan restor remain natur teeth implant restor invas fix occlus reconstruct dentit defect minim invas fix occlus reconstruct dentit defect sequenti reconstruct process involv minim invas restor remain natur teeth implant restor edentul area occlus chang revers non revers simultan complet minim invas natur teeth restor implant support crown bridg ideal occlus design show obvious advantag digit integr use digit technolog intraor scan kinemat face bow virtual articul comput aid design comput aid manufactur cadcam could integr stage occlus reconstruct includ overal document assess restor determin function restor space precis design fabric provision final restor take account esthet function preserv follow document assess restor integr process optim clinic process improv restor accuraci articl briefli describ concept minim invas occlus reconstruct dentit defect integr strategi digit sequenti restor
|
D015921;D009066
|
T033;T074
|
36,266,071
|
construct applic virtual patient prosthodont recent year rapid develop digit technolog applic oral virtual patient prosthodont orthodont oral maxillofaci surgeri disciplin gradual increas although focus oral virtual patient vari differ disciplin applic oral virtual patient assist predict treatment effect formul treatment plan good prospect construct accuraci present effect oral virtual patient influenc sourc three dimension imag method registr base studi clinic experi team research team sourc imag construct method clinic applic virtual patient prosthodont present provid refer normal applic develop oral virtual patient offer futur develop direct oral virtual patient
|
D009970;D013515
|
T091
|
36,266,070
|
guidelin chairsid comput aid design comput aid manufactur ceram rehabilit rapid develop digit techniqu lack refer standard chairsid comput aid design comput aid manufactur cadcam oper applic imper draft guidelin chairsid cadcam restor techniqu ceram therefor societi prosthodont chines stomatolog associ recruit expert compos recommend applic guidelin base relev literatur clinic experi includ select indic tooth prepar optic impress make key step guidelin aim provid standard oper procedur improv qualiti long term success rate chairsid cadcam rehabilit ceram
|
D017267;D017076
|
T170;T066
|
36,266,069
|
expert consensus orbit defect restor prosthesi orbit defect common type maxillofaci defect reconstruct surgic mean present howev expert consensus make prosthesi accur quick reconstruct appear patient order solv problem societi prosthodont chines stomatolog associ invit sever expert professor relat profession field china joint studi develop expert consensus purpos consensus comprehens explain knowledg prosthesi repair orbit defect aspect basic theori prosthesi principl prosthesi materi prosthesi techniqu guid prosthesi physician understand master knowledg techniqu improv overal level orbit defect repair reconstruct china improv qualiti life patient better serv major patient
|
D011788;D015921
|
T078;T074
|
36,266,066
|
efficaci bortezomib cyclophosphamid dexamethason cardiac al amyloidosi cardiac light chain al amyloidosi condit poor prognosi report retrospect analysi compar tradit melphalan dexamethason protocol cyclophosphamid bortezomib dexamethason late stage cardiac al amyloidosi primari end point overal surviv haematolog respons regimen provid meaning respons difficult treat patient group
|
D000075363;D000686
|
T047;T191
|
36,266,064
|
novel non invas index oxygen predict outcom patient high flow nasal cannula pilot studi predict success therapi acut respiratori failur clinic import fox index high flow rate fio spo retrospect appli patient requir high flow nasal prong hypoxaem hypercapn respiratori failur fox index could predict success failur high flow nasal prong hour use non invas marker add clinician toolbox manag respiratori failur repres import proof concept prospect studi
|
D063087;D012131
|
T061;T047;T046
|
36,266,062
|
complementari altern therapi palliat set complementari altern medicin cam encompass wide rang medic herbal dietari physic therapi usual consid within realm convent therapeut approxim two third australian popul use cam around half number discuss use product doctor clinic use common seen patient life limit ill often experi high burden symptom howev also case mani therapi demonstr efficaci particular often broad list condit symptom chosen use depend whether sold medic sold food supplement import illeg distribut via nonstandard therapeut channel sever product report toxic sever advers effect batch irregular drug interact therapi awar togeth lack standardis product lack interchang brand made prescrib unwil put patient risk harm support use articl cover general pharmacolog principl around use small select chemic use medic set enabl guidanc use
|
D000529
|
T061;T091
|
36,266,054
|
seizur semiolog antibodi associ autoimmun enceph assess seizur characterist antibodi ab associ autoimmun enceph ab ae preval ab n methyl aspart receptor nmdar leucin rich glioma inactiv protein lgi glutam acid decarboxylas gad
|
D004660;D013226
|
T047
|
36,266,053
|
multipl sclerosi csf enrich follicular cell display theom signatur tertiari lymphoid structur aggreg report mening patient multipl sclerosi ms especi progress stage strong associ cortic lesion disabl besid b cell structur compris follicular helper tfh cell crucial support b cell differenti tfh cell play pivot role amplifi autoreact b cell promot autoantibodi product sever autoimmun diseas known ms studi examin phenotyp frequenc transcriptom circul ctfh cell blood csf patient relaps remit ms rrms
|
D009103;D006377
|
T047;T025
|
36,266,052
|
patient sever multipl sclerosi exhibit function alter cd regulatori cell multipl sclerosi ms chronic inflammatori demyelin diseas cns studi immun dysfunct ms most focus cd treg role cd treg remain larg unexplor previous evidenc suppress properti rat human cd cdrc lowneg treg healthi individu express forkhead box p foxp act interferon gamma ifn transform growth factor beta tgf interleukin il secret regul immun respons control diseas transplant reject better understand cd cdrc lowneg treg contribut ms patholog investig phenotyp function transcriptom patient ms
|
D009103;D020529;D004681
|
T047;T050
|
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