PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,264,097 | efficaci safeti actovegin treatment intermitt claudic result intern multicent placebo control random phase iiib clinic trial apollo studi aim assess efficaci safeti actovegin treatment patient fontain stage iib peripher arteri diseas pad | D007383;D016491 | T047 |
36,264,086 | therapeut efficaci human jaa f anti thomsen friedenreich antibodi construct hala hl human breast lung cancer xenograft model thomsen friedenreich antigen tf ag found human carcinoma cryptic normal tissu human high specif hjaa f hala hl antibodi target tf ag without bind tf ag beta found surfac glycolipid normal cell relat affin hl time hala would seem favor superior efficaci howev increas affin result less tumor penetr assess potenti therapeut efficaci antibodi four human cancer mous xenograft model treat hala hl tumor xenograft model use human non small cell lung cancer h small cell lung cancer htb nude mice human tripl negat breast cancer mda mb hcc scid mice hala signific decreas tumor growth breast lung cancer model hala show statist equal better efficaci hl superior product capabl result suggest hala may superior nake antibodi antibodi drug conjug radiolabel antibodi howev higher affin hl may lead better efficaci bi specif therapi bind decreas due presenc one tf ag bind site | D008175;D002289;D018796 | T121;T129;T191 |
36,264,074 | fsp novel keapnrf target gene regul ferroptosi radioresist lung cancer studi target coq fsp axi drive ferroptosi radiat resist keap inact lung cancer publish earlier natur communic author identifi novel keapnrf target gene fsp demonstr fsp play essenti role nrf mediat ferroptosi resist radioresist keap defici lung cancer cell current mani nrf target gene found particip regul ferroptosi exact one play domin role seem unclear studi propos fsp key effector nrf mediat ferroptosi resist radioresist keap defici lung cancer cell discuss manuscript | D000079403;D008175 | T191;T043 |
36,264,073 | platelet deriv growth factor pdgf cross signal via non correspond receptor indic bypass signal colorect cancer platelet deriv growth factor pdgf signal besid growth factor mediat signal pathway like vascular endotheli growth factor vegf epiderm growth factor egf seem play crucial role tumor develop progress recent provid evid upregul pdgf express uicc stage iv primari colorect cancer crc demonstr pdgf mediat induct pikaktmtor signal crc cell line present studi sought follow previous find explor altern receptor cross bind potenti pdgf crc analysi primari human colon tumor sampl demonstr upregul pdgfr vegfr vegfr gene uicc stage iii tumor immunohistolog analysi reveal co express pdgf putat cross bind partner vegfr egfr analyz sever crc cell line pdgfr pdgfr vegfr vegfr protein express found receptor variabl express amongst investig cell line interest wherea caco sw cell show express analyz receptor ht cell express vegfr vegfr howev stimul ht cell pdgf result upregul vegfr vegfr express despit absenc pdgfr express mimick effect vegf stimul moreov pdgf recov ht cell prolifer simultan treatment vegfr egfr inhibitor result provid first evid pdgf cross signal altern receptor colorect cancer support anti pdgf therapi combin strategi alongsid vegf egf target even tumor lack pdgfr express | D010982;D015179 | T123;T191;T116 |
36,264,067 | machin learn base surviv predict glioma use larg scale registri data glioma common central nervous system tumor exhibit poor clinic outcom abil estim prognosi crucial patient provid order select appropri treatment machin learn ml allow sophist approach surviv predict use real world clinic paramet need achiev superior predict accuraci employ cox proport hazard cph model support vector machin svm model random forest rf model larg glioma dataset patient diagnos explor optim approach surviv predict featur employ age sex surgic resect status tumor histolog tumor site administr radiat therapi rt chemotherapi status concord index c index employ assess accuraci surviv time predict three model perform well predict accuraci ci cph svm rf model respect best perform achiev incorpor rt chemotherapi administr status emerg key predict featur within subset glioblastoma patient similar predict accuraci achiev find prompt stricter clinician oversight registri data accuraci qualiti assur move toward meaning predict abil use ml approach glioma | D005910 | T191 |
36,264,065 | molecular mechan afadin substrat recruit receptor phosphatas ptprk via pseudophosphatas domain protein tyrosin phosphatas receptor type kappa ptprk transmembran receptor link extracellular homophil interact intracellular catalyt activ previous show ptprk promot cell cell adhes select dephosphoryl sever cell junction regul includ protein afadin fearnley et al demonstr afadin recruit dephosphoryl direct bind ptprk pseudophosphatas domain map interact putat coil coil cc domain afadin separ amino acid substrat ptyr residu identifi residu defin ptp specif explain afadin select dephosphoryl ptprk yet close relat receptor tyrosin phosphatas ptprm work demonstr ptp substrat specif determin protein protein interact distal activ site explain ptprk ptps achiev substrat specif despit lack specif sequenc context substrat ptyr furthermor demonstr interact phosphoryl independ mediat via bind non catalyt domain highlight receptor ptps could function intracellular scaffold addit catalyz protein dephosphoryl | D008840;D017027 | T123;T126;T116 |
36,264,063 | extens amino function graphen captur carbon dioxid develop robust carbon dioxid co scaveng challeng paramount problem modern human present work report prospect co sorbent base amino function graphen fg amino fg retain favor physicochem properti graphen acquir capabl chemic fix co via carbam acid format mechan present work comprehens investig co captur prospect extens amino fg use hybrid densiti function theori show six amino group graft remain stabl subsequ chemisorb co per benzen ring two function group benzen ring four group benzen ring repres thermodynam stabl molecular configur number carbon atom equal number function group thermochemistri chemisorpt general negat impact increas densiti function group howev less favor gibb free energi compens sever fold higher number prospect reaction site thermochemistri result ration consid steric hindranc surfac graphen context state hybrid genuin geometri amino carboxamido function group function chemisorpt decreas hydrophob graphen deriv therefor foster develop novel robust chemic engin setup | D006108 | T196;T109 |
36,264,059 | enrich dietari satur fatti acid induc train immun via ceramid product enhanc sever endotoxemia clearanc infect train immun innat immun memori respons induc primari inflammatori stimulus sensit monocyt macrophag secondari pathogen challeng reprogram host respons infect inflammatori diseas dietari fatti acid act inflammatori stimuli unknown act primari stimuli induc train immun find mice fed diet enrich exclus satur fatti acid ketogen diet kd confer hyper inflammatori respons system lipopolysaccharid lps increas mortal independ diet induc microbiom hyperglycemia find kd alter composit hematopoiet stem cell compart enhanc respons bone marrow macrophag monocyt splenocyt secondari lps challeng lipidom identifi enhanc free palmit acid pa pa associ lipid kd fed mice serum found pre treatment physiolog relev concentr pa induc hyper inflammatori respons lps macrophag depend synthesi ceramid vivo found system pa confer enhanc inflamm mortal respons system lps phenotyp revers day post pa exposur convers find pa exposur enhanc clearanc candida albican rag mice last show oleic acid deplet intracellular ceramid revers pa induc hyper inflamm macrophag enhanc mortal respons lps implic enrich dietari sfas specif pa induct long live innat immun memori highlight plastic innat immun reprogram dietari constitu | D005227;D019446 | T123;T047;T168;T109 |
36,264,057 | altern splice apoptosi gene promot human cell surviv altern splice occur vast major human gene give rise distinct mrna protein isoform other previous identifi hundr gene chang isoform express upon cell activ via altern splice howev chang link activ input function output remain larg unknown investig costimul cell cd receptor impact altern splice cell activ cell receptor tcr cd find cd signal alon minim impact splice enhanc extent chang tcr induc altern splice event interest set cd enhanc splice event occur within gene encod key compon apoptot signal pathway name caspas bax bim use crispr edit cell antisens oligo forc express specif isoform show three gene isoform induc cdcd costimul promot resist apoptosi chang three gene togeth function combinatori promot cell viabil final show jnk signal pathway induc downstream cdcd costimul requir splice event highlight co regul togeth find demonstr altern splice key mechan costimul cd promot viabil activ cell | D013601;D018106 | T129;T116;T025;T192 |
36,264,056 | structur sar cov protein lipid nanodisc sar cov encod four structur protein incorpor virion spike envelop e nucleocapsid n membran play essenti role viral assembl organ structur protein physic interact direct site viral bud abund protein viral envelop target patient antibodi compel target vaccin therapeut still structur molecular basi role virion format unknown present cryo em structur sar cov lipid nanodisc resolut form kda homodim structur relat sar cov orfa viroporin suggest share ancestr origin structur comparison reveal intersubunit gap creat small enclos pocket larg open caviti orfa consist structur role ion channel activ respect display strike electroposit cytosol surfac may import interact n viral rna molecular dynam simul show high degre structur rigid simpl lipid bilay support role homodim scaffold viral assembl togeth result provid insight role coronavirus assembl structur | D000086402;D000086382 | T005;T067;T047 |
36,264,054 | impact exercis train differ intens level cardiac function exercis capac patient chronic heart failur prospect cohort studi investig train differ intens level cardiac function exercis capac health relat qualiti life patient chronic heart failur | D017079;D006333 | T201;T047;T046 |
36,264,053 | rare earth dope nanocryst bioimag near infrar region rare earth dope nanocryst wide use medic diagnost bioimag due narrow luminesc emiss spectra nm long lifetim photobleach properti especi near infrar nir region deeper tissu imag achiev low background luminesc high spatial resolut precis imag guid diagnosi treatment achiev use multimod imag mrictnirpa focus construct rare earth dope nanocryst optic properti progress nanocomposit bioimag nir region addit limit stage field bioimag prospect futur technolog develop rare earth dope nanocryst present | D008674;D053758 | T196;T073 |
36,264,039 | total synthesi scabrolid f first total synthesi scabrolid f norcembranolid isol soft coral sinularia scabra describ hydroxycarboxyl acid key synthet intermedi synthes converg manner fragment coupl obtain hydroxycarboxyl acid subject macrolacton subsequ transannular ring close metathesi rcm furnish scabrolid f synthet protocol extend total synthesi norcembranolid | D004224;D037421 | T204;T109 |
36,264,038 | fu brick tea polysaccharid prevent obes via gut microbiota control promot adipocyt brown thermogenesi antiobes efficaci under mechan polysaccharid extract fu brick tea fbtp investig week administr fbtp dose depend inhibit increas bodi weight weight epididym retroperiton inguin white adipos tissu stimul beig fat develop brown adipos tissu deriv nonshiv thermogenesi high fat diet induc obes mice fbtp protect obes associ abnorm serum adiponectin leptin indic posit regul energi metabol fbtp revers gut dysbiosi enrich benefici bacteria exampl lactobacillus parabacteroid akkermansia bifidobacterium roseburia result fecal microbiota transplant confirm fbtp induc microbi shift contribut adipos brown thermogenesi therebi allevi host adipos glucos homeostasi dyslipidemia relat hepat steatosi studi demonstr great potenti fbtp prebiot like activ prevent diet induc obes relat metabol complic via gut microbiota deriv enhanc fat burn energi expenditur | D000069196 | T007;T001 |
36,264,028 | oral metal organ gel protect whole cell biosensor situ monitor nitrosamin gastrointestin tract nitrit type food addit prove convert genotox nitrosamin gastrointestin tract intestin flora appropri method situ detect nitrosamin herein plasmid introduc saccharomyc cerevisia respond nitrosamin induc dna damag activ pmag base dna damag repair ddr design whole cell biosensor wcbs monitor situ generat nitrosamin report gene express enhanc green fluoresc protein egfp order protect valid wcbs pmag yeast gastric acid environ type metal organ gel mog coordin fe thiodiacet acid tda prepar emb wcbs mog fe tda gastric acid resist deliv pmag yeast gut without compromis perform pmag yeast detect situ generat nitrosamin genotox nitrosamin convert nitrit success detect gastrointestin tract mice | D009602;D015374 | T131;T059;T075;T109 |
36,264,027 | copper catalyz n direct distal c sp h function toward azepan herein report copper catalyz formal aza annul n fluorosulfonamid dien enyn synthesi structur divers alkenealkyn contain azepan reaction featur select function distal unactiv c sp h bond broad substrat scope thus allow late stage modif pharmaceut natur product radic mechan involv hydrogen atom transfer n radic facil coupl alkyl radic dien enyn construct azepan motif via c n bond format propos | D003300;D002244 | T123;T196;T121 |
36,264,023 | cu catalyz switchabl asymmetr defluoroalkyl cycloaddit trifluoropropen chiral fluorin amino ester pyrrolidin privileg scaffold synthet chemistri exhibit uniqu biolog properti report facil prepar compound copper catalyz switchabl defluoroalkyl cycloaddit trifluoropropen asymmetr fashion choic solvent chiral ligand crucial effici transform exquisit chemoselect pattern ident start materi rapid reliabl incorpor gem difluoroalken trifluoromethyl cf motif generat divers rang enantioenrich fluorin build block good excel yield high asymmetr induct | D003300 | T123;T196;T121 |
36,264,018 | oxoammonium salt promot multifunction satur cyclic amin base oxo cyclic iminium ion intermedi herein describ conveni method multipl c sp h bond function satur cyclic amin oxoammonium salt promot oxid afford oxo cyclic iminium ion key intermedi follow cascad addit thiocyan divers n contain nucleophil green solvent etoh notabl chiral spiro azapolyheterocycl prepar enantioselect gt dr ee cystein serin ester use substrat moreov concis late stage modif sever natur product deriv accomplish use method | D000588;D000218 | T109 |
36,264,016 | aptam base cancer cell analysi treatment aptam class singl strand dna rna oligonucleotid exclus bind various target high affin select regard chemic antibodi aptam possess sever intrins advantag includ easi synthesi conveni modif high programm good biocompat recent decad mani studi demonstr superior aptam molecular tool various biolog applic particular area cancer theranost review focus recent progress develop aptam base strategi precis analysi treatment cancer cell | D052157;D009369;D018295 | T191;T114 |
36,264,009 | comput guid enzymat studi schizochytrium sourc malonyl coa acp transacylas malonyl coa acp transacylas mat domain respons select incorpor malonyl build block biosynthesi polyunsatur fatti acid pufa eukaryot microalga schizochytrium marin bacteria moritella marina photobacterium profundum shewanella elucid structur basi under substrat specif catalyt mechan mat help improv yield qualiti pufa methodolog guid molecular dynam simul carri identifi mutat specif confer residu within mat domain schizochytrium combin mutagenesi cell free protein synthesi vitro biochem assay dissect nearbi interact molecular mechan relev bind catalysi found reorient ser c bond establish distinct proton transfer chain ser asn ser catalysi gln replac tyrosin shorten distanc n ser facilit faster proton transfer rate allow better use acyl substrat wild type furthermor screen mutant display increas pufa accumul find provid import insight studi mat protein engin benefit dissect molecular mechan pufa relat catalyt domain | D008316;D058009 | T123;T204;T114 |
36,263,997 | coordin anchor mix luminophor two isostructur hybrid layer achiev tunabl room temperatur phosphoresc room temperatur phosphoresc rtp materi widespread applic biolog imag anticounterfeit optoelectron devic predesign metal organ complex moc rtp materi base moc system receiv huge attent research coordin anchor luminophor enhanc rigid organ molecul restrict nonradi transit offer opportun generat moc materi captiv rtp perform hitherto moc base rtp materi featur singl luminophor ligand develop new moc system rtp function still challeng herein use mix ligand synthet strategi produc isostructur moc zn timb x tpa h x cl x br timb tris methyl h imidazol yl benzen h x tpa dichloroterephthal dibromoterephthal acid modul rtp properti result product via synergi coordin anchor substitut synthesi featur similar coordin layer compos neutral timb anion x tpa ligand provid good structur model tune rtp perform final product via substitut synthesi differ report rtp materi base moc system studi provid general way build modul moc base rtp materi assist coordin anchor substitut synthesi strategi | D049449 | T070 |
36,263,996 | multicompon reaction privileg tool multitarget direct ligand strategi alzheim diseas therapi among neurodegen patholog affect older popul alzheim diseas common type dementia lead neurocognit behavior disord complex progress age relat multifactori diseas character seri high interconnect pathophysiolog process within last decad multitarget direct ligand strategi emerg viabl approach develop complex molecul exhibit sever pharmacophor target differ enzym receptor involv pathogenesi diseas herein focus use multicompon reaction hantzsch biginelli ugi develop biolog activ multitop ligand | D000544 | T047;T048 |
36,263,995 | tmt plex higher order multiplex inher interfer correct tandem mass tag tmt technolog enabl mass spectrometri base multiplex sampl profil protein abund degre isobar label tmt increas recent channel enabl develop higher throughput assay tmt experi measur report tag intens confound ratio compress although pre post acquisit method develop decreas interfer ratio compress remain problem complex sampl work sun et al present tmt plex workflow combin tmt plex tmtpro plex label strategi use inher featur address ratio compress problem increas tmt throughput quantit accuraci potenti applic | D040901;D053719 | T063;T091 |
36,263,993 | synthesi azetidin nitron exomethylen oxazolin copper catalyz rearrang electrocycl cascad strategi varieti azetidin nitron prepar moder good yield copper combin aminopyridin catalyz skelet rearrang propargyl oxim mechanist studi reveal reaction undergo copper catalyz tandem rearrang electrocycl ring open recycl four step one pot substitu terminus alkyn oxim moieti signific impact format azetidin nitron exomethylen oxazolin respect furthermor obtain azetidin nitron could easili particip cycloaddit alkyno paracyclophan deriv azetidin nitron synthes yield five step bromo paracyclophan | D003300;D001384 | T123;T196;T121;T109 |
36,263,977 | calor restrict friend foe effect metabol status associ intestin microbiom metabolom daili calori restrict cr shown benefit weight loss allevi metabol disord investig effect three cr regimen ie cr cr cr less averag daili calori intak respect metabol paramet gut microbiom composit relat metabolit healthi mice compar mice fed ad libitum al cr dose depend reduc bodi weight weight liver epididym adipos tissu enhanc insulin sensit glucos toler lipid homeostasi moreov express level intestin tight junction protein ie zo claudin occludin signific promot cr al mice demonstr cr induc improv intestin barrier integr cr contribut enrich benefici microbiota eg lactobacillus bacteroid akkermansia increas propion acid level notabl cr deleteri caus liver injuri enhanc hepat inflammatori cytokin ie il il tnf lipopolysaccharid accompani high level trimethylamin tma trimethylamin oxid tmao relat cr alter gut microbiota structur fecal metabolom addit found differenti impact cr amino acid absorpt metabol find support health promot benefit daili calori intak metabol status regul gut microbiota healthi mice howev excess cr caus liver injuri gut microbiota depend elev tmao differenti effect cr regimen intestin microbiom fecal metabolom provid novel insight dietari pattern gut microbiom interact link host metabol | D000069196 | T007;T001 |
36,263,972 | open latarjet procedur versus arthroscop autolog tricort iliac crest bone graft anterior inferior glenohumer instabl glenoid bone loss purpos studi compar open latarjet procedur versus arthroscop autolog tricort iliac crest bone graft aicbg techniqu recurr anterior inferior glenohumer instabl glenoid bone loss | D007593;D012783;D012785 | T030;T033;T023;T037;T047 |
36,263,960 | antiretrovir therapi adher pattern virolog suppress emerg drug resist nest case control studi uganda south africa relationship distinct antiretrovir therapi art adher pattern risk drug resist well understood | D015658;D019428;D019380 | T121;T047 |
36,263,959 | cellulos fast pyrolysi activ intramolecular hydrogen bond convers ined biomass fast pyrolysi promis rout sustain product renew fuel valu ad chemic low select toward desir product hamper econom viabil understand molecular level reaction pathway biomass fast pyrolysi could key overcom challeng howev effect intramolecular interchain hydrogen bond near reaction center thorough explor work reaction pathway kinet fast pyrolysi cellulos major compon biomass investig use densiti function theori new intramolecular hydroxyl activ mechan present cellulos activ calcul incorpor noncoval interact accur captur activ energi kcal mol agreeabl appar activ energi measur experiment find cellulos pyrolysi provid insight investig interact real life biomass pyrolysi | D000077319;D002482 | T123;T122;T070;T109 |
36,263,945 | develop noncoval small molecul keap nrf inhibitor fragment base drug discoveri target protein protein interact ppi transcript factor nuclear factor erythroid relat factor nrf repressor kelch like ech associ protein keap constitut promis strategi treat diseas involv oxid stress inflamm fragment base drug discoveri fbdd campaign result novel high affin k nm cell activ noncoval small molecul keap nrf ppi inhibitor screen fragment use orthogon assaysfluoresc polar fp thermal shift assay tsa surfac plasmon reson spr valid hit satur transfer differ std nmr lead high prioriti hit thirteen co structur show fragment bind main p p subpocket keap kelch domain three fluorenon base fragment featur novel bind mode optim structur base drug discoveri therebi disclos sever fragment hit includ bind mode show fbdd perform find new small molecul keap nrf ppi inhibitor | D051267;D055808 | T062;T123;T116 |
36,263,940 | neural underpin respir associ rest state fmri network respir induc motion co fluctuat rest state fmri rsfmri scan lead non neural artifact rsfmri signal meantim crucial physiolog process respir direct drive neural activ chang brain may therebi modul rsfmri signal nonetheless potenti neural compon respir fmri relationship larg unexplor elucid issu simultan record electrophysiolog rsfmri respir signal rat data show respir inde associ neural activ chang evidenc phase lock relationship slow respir variat gamma band power electrophysiolog signal record anterior cingul cortex intrigu slow respir variat also link characterist rsfmri network mediat gamma band neural activ addit respir relat brain network disappear brain wide neural activ silenc isoelectr state respir maintain confirm necessari role neural activ network taken togeth studi identifi respir relat brain network underpin neural activ repres novel compon respir rsfmri relationship distinct respir relat rsfmri artifact open new avenu investig interact respir neural activ rest state brain network healthi diseas condit | D008279;D001931 | T060;T062;T170;T059 |
36,263,932 | peer review without gatekeep elif chang editori process emphas public review assess preprint elimin acceptreject decis peer review | D017712;D011643 | T057 |
36,263,929 | structur flexibl yeast nua histon acetyltransferas complex nua protein complex acetyl histon h ha activ transcript dna repair report resolut cryo electron microscopi structur central hub nua flexibl tether histon acetyltransferas hat trimer independ nua involv transcript interact nucleosom tintin modul hub contain larg tra subunit core includ swc arp act eaf c termin region epl eaf stand primari scaffold factor interact tra swc epl subunit contribut conserv hsa helix arp modul use nucleosom bind assay find hat modul anchor core epl recogn hkme nucleosom hyperacetyl h tail tintin modul anchor core via eaf recogn nucleosom hyperacetyl ha h tail togeth known interact tra site specif transcript factor data suggest model tra recruit nua specif genom site allow flexibl hat tintin modul select nearbi nucleosom acetyl | D012441;D029701 | T004;T116 |
36,263,926 | small molecul inhibitor lymphocyt perforin focus immunosuppress infect autoimmun new drug precis target immun mechan critic cytotox lymphocyt ctl natur killer nk cell driven patholog desper need perspect explor cytolyt protein perforin target therapeut intervent perforin play indispens role ctlnk kill control rang immun patholog encod singl copi gene redund function immunosuppress target protein would provid first ever therapi focus specif one princip cell death pathway contribut allotranspl reject underpin multipl autoimmun postinfecti diseas drug select block perforin depend cell death current clinic use perspect review publish novel small molecul inhibitor conclud vivo proof concept experi perform mous model perforin mediat immun patholog provid potenti pathway toward clinic use therapeut agent | D003602;D015551 | T046;T043 |
36,263,920 | classif model weight regular improv reproduc neuroimag signatur select machin learn ml extens appli brain imag studi aid diagnosi psychiatr disord select potenti biomark due high dimension imag data heterogen subtyp psychiatr disord reproduc ml result brain imag studi drawn increas attent reproduc brain imag primarili examin term predict accuraci howev achiev high predict accuraci discov relev featur two separ relat goal import yet investig problem reproduc featur select brain imag studi propos new metric quantifi reproduc neuroimag featur select via bootstrap estim reproduc index r index featur reciproc coeffici variat absolut mean differ across larger number bootstrap sampl integr r index regular classif model penalti weight reproduc featur larger r index assign smaller penalti weight thus like select propos model simul multimod neuroimag data use examin perform propos model result show propos r index model effect separ inform featur nois featur addit propos model yield similar higher predict accuraci standard regular classif model reduc coeffici estim error improv achiev propos model essenti advanc understand select brain imag featur well associ psychiatr disord | D059906;D000069550 | T060;T066 |
36,263,919 | communic effici estim infer high dimension quantil regress base smooth decorrel score distribut estim base differ sourc observ drawn attent modern statist learn practic due expens cost time consum process collect data case sampl size local site small dimens covari larg may far larger sampl size site articl focus distribut estim infer preconceiv low dimension paramet vector high dimension quantil regress model small local sampl size specif consid data inher distribut propos two communic effici estim general decorrel score approach conquer slow converg rate nuisanc paramet estim adopt smooth techniqu base multiround algorithm risk bound limit distribut propos estim given finit sampl perform propos estim studi simul applic gene express dataset also present | D000465;D003142 | T054;T170;T097;T080 |
36,263,918 | flexibl propens score estim strategi cluster data observ studi exist studi suggest superior perform nonparametr machin learn logist regress propens score estim howev unclear whether advantag nonparametr propens score model carri set cluster individu especi unmeasur cluster level confound work examin perform logist regress main effect bayesian addit regress tree general boost model propens score weight cluster set cluster account includ either cluster indic random intercept simul data three hypothet observ studi vari sampl cluster size confound generat level includ cluster level confound unobserv analys binari treatment continu outcom generat base seven scenario vari relationship treatment confound linear addit nonlinearnonaddit nonaddit unobserv cluster level confound result suggest sampl cluster size larg nonparametr propens score estim may provid better covari balanc bias reduct confid interv coverag regardless degre nonlinear nonaddit true propens score model sampl cluster size small howev nonparametr approach may becom vulner unmeasur cluster level confound thus may better altern multilevel logist regress appli method nation longitudin studi adolesc adult health data estim effect team sport particip adolesc adulthood depress symptom | D057216 | T081 |
36,263,917 | excess high repair tension decreas microvascular blood flow within rotat cuff repair tension microvascular blood flow within rotat cuff critic impact tendon heal rotat cuff repair howev relationship repair tension microvascular blood flow within rotat cuff remain unclear | D017006;D000070636 | T033;T023;T037;T047 |
36,263,899 | evid base strategi navig complex dietari dna metabarcod repli clear benefici elimin low abund sequenc aris error dietari dna metabarcod studi purg low abund sequenc risk elimin real sequenc complic ecolog analys prior literatur review note dna sequenc relat read abund rra threshold help amelior fals posit taxon occurr histor emphasi util foster uncertainti associ risk inflat fals negat rate littleford colquhoun et al address combin simul studi empir data set illustr issu provid blueprint simul studi sensit analys help investig avoid overcorrect therebi bolster confid ecolog infer awar cost benefit abund filter need accur character dietari distribut critic import understand anim diet nutrit trophic network highlight need rais awar critiqu paper emphas mislead notion fals posit interact speci present fundament incorrect network structur network ecolog wherea fals negat provid correct incomplet version network tercel cuff assert reliabl result erod fals posit resili omiss true posit riski run counter evid unfortun abund filter method introduc fals negat higher rate elimin fals posit therebi undermin analysi otherwis reliabl sequenc data overcorrect qualit alter ultim undermin ecolog interpret | D058893;D004247 | T062;T087;T123;T114 |
36,263,891 | cobalt iii catalyz dmso involv allyl dicarbonyl compound alken cobalt iii catalyz allyl dicarbonyl compound report situ generat allyl reagent alken dimethyl sulfoxid dmso novel protocol enabl high regio stereoselect access broad rang allyl dicarbonyl compound transform dmso play role c sourc incorpor alken form allyl reagent allyl methyl thioether moreov multipl step pathway propos ration mechan studi involv silver mediat coupl co iii catalyz allyl intermolecular nucleophil substitut | D000475;D000498 | T109 |
36,263,890 | lysosom target fluoresc probe visual endogen exogen methylglyox live cell zebrafish develop lysosom target fluoresc probe visual endogen exogen methylglyox mgo live cell import implic associ diseas herein lysosom target fluoresc probe mgo naph design synthes detect mgo high select probe contain naphthalimid fluoresc group phenylenediamin mgo recognit group morpholin lysosom target group fluoresc probe could detect endogen exogen mgo live cell precis target stain lysosom could also detect mgo live zebrafish result show probe mgo naph potenti visual mgo lysosom | D005456;D015027 | T130;T013 |
36,263,885 | risk percept inform receiv occup engag worker univers hospit face covid pandem hospit worker face pandem lack knowledg procedur resourc generat differ experi base perceiv risk exposur consid pertin conduct studi learn risk percept inform receiv occup engag worker univers hospit face pandem | D058873;D000086382 | T047;T067 |
36,263,882 | therapeut sub stanc current practic therapeut conduct preparatori session substanc assist psychotherapi systemat review clinic trial current investig potenti substanc assist psychotherapi sapt treatment sever psychiatr condit potenti therapeut effect sapt may influenc contextu factor includ prepar prior integr substanc assist therapi session | D011613;D001523 | T061;T048 |
36,263,877 | long term effect school educ educ longitudin view motiv behaviour youth adulthood school learn enabl peopl self determin live long last relev particip educ essenti outcom contemporari adult educ research show belief memori one school year impact motiv pursu educ work life howev almost longitudin research exist investig long term forc behind adult motiv educ henc present studi examin whether student learn relat behaviour cognit emot develop school year relat subject valu place educ expect success solv learn task thus likelihood particip educ correspond structur equat analys data german panel studi life n reveal learn behaviour abil self concept test anxieti age along individu chang age associ differ way attain valu subject cost place educ expect success age contrast influenc youth characterist likelihood particip educ could found find indic especi develop learn relat cognit emot secondari school sustain relat individu success expect achiev valu educ long term depend investig regard academ domain socio econom pathway | D009042;D000124 | T078;T053;T041;T080 |
36,263,874 | chang sibl similar educ among finnish cohort born contribut patern matern educ among mani social characterist run famili educ one strong persist long term chang educ reproduct within famili across generat gender specif driver chang remain partial unclear use popul data finnish sibl parent assess level trend intergener persist educ among cohort born varianc educ share among sibl remain stabl time parent educ steadili increas explanatori power share varianc among cohort born among cohort born direct contribut matern educ net patern educ sibl similar doubl across cohort direct contribut patern educ remain stabl gender sibl resembl educ close opposit gender counterpart grow import matern educ time surpass predict power patern educ demonstr import qualit chang determin educ stratif grow import mother educ plausibl result strengthen meritocrat achiev women educ associ increas women defin social posit famili incorpor educ parent futur analys intergener reproduct educ probabl increas salient | D035781;D005220 | T099 |
36,263,861 | complex organ doxorubicin polystyren sulfon chain impact doxorubicin dimer quench anthracyclin doxorubicin hydrochlorid dx posit charg fluoresc drug water self associ non fluoresc antiparallel dimer upon increas concentr andor ionic strength posit charg dx allow complex negat charg polym drug carrier fluoresc dx follow complex polyanion polystyren sulfon pss studi fluoresc emiss dx decreas presenc pss almost complet quench ratio r pss monom dx molecul larger increas r valu result progress recoveri fluoresc circular dichroism pss dx complex show invert characterist band dx dimer suggest presenc parallel dimer concentr dx dimer water molecular dynam studi corrobor preferenti orient dx parallel dimer interact pss show dx molecul interact bind pocket pss monom rather one singl monom increas ionic strength result recoveri fluoresc without appar releas dx pss dx complex shown dosi nmr pss act templat concentr dx trigger dimeris orient dx molecul charg group face negat charg pss monom | D011137;D004317 | T121;T122;T195;T109 |
36,263,855 | improv emiss yb iii ion triazacyclononan base macrocycl ligand compar cyclen base one yb iii complex base ligand triazacyclononan tacn macrocycl core synthesis complex carri methoxymethyl substitut carbostyril chromophor serv light harvest antenna ligand suppli nitrogen oxygen donor via methylenecarboxamid picolin donor creat charg complex octadent bind environ electron properti picolin modul vari substitut posit ome h cl cf cyclic voltammetri indic tacn base yb iii complex easier reduc analog cyclen complex first reduct event like picolin centr follow format reduc speci antenna excit yield yb iii luminesc near infrar nir region case antenna photophys properti consist intraligand photoinduc electron transfer excit carbostyril picolin group relat quantum yield yb iii luminesc determin lowest valu obtain complex effici antenna picolin photoinduc electron transfer despit intraligand electron transfer quench antenna tacn base yb complex emiss cyclen analogu highlight influenc ligand structur luminesc properti nir emiss lanthanid iii ion | D000080027;D028581 | T123;T196;T109 |
36,263,813 | catalyt inact dna ligas iv promot dna repair live cell dna doubl strand break dsbs induc extern genotox agent ioniz radiat genotoxin intern process recombin intermedi lymphocyt replic error dna end induc genotox process often ligat requir potenti mutagen end process render end compat ligat non homolog end join nhej use singl molecul approach loparo et al propos nhej fidel maintain restrict end process ligat compet short rang nhej complex maxim fidel dna repair vitro studi show although short rang nhej complex requir dna ligas iv lig catalyt activ dispens use cellular model show inact lig robust promot dna repair live cell compar repair product wild type cell isol cell inact lig show somewhat increas fraction util micro homolog mh join site consist altern end join ej unlik ej absenc nhej larg percentag joint isol cell inact lig occur mh thus clear distinct ej final biochem assay demonstr inact lig complex promot activ dna ligas iii lig | D059766;D004260 | T045 |
36,263,809 | regulatori landscap multipl brain region outbr heterogen stock rat heterogen stock hs rat genet divers outbr rat popul wide use studi genet behavior physiolog trait map quantit trait loci qtl associ transcript chang would help identifi mechan under trait generat genotyp transcriptom data five brain region hs rat identifi cis qtls associ express splice chang across five brain region valid effect use allel specif express data identifi case eqtl coloc genom wide associ studi gwas result nine physiolog trait compar dataset human data genotyp tissu express gtex project found hs rat data yield twice mani signific eqtl similar size human dataset also identifi modest high signific correl genet regulatori variat among ortholog gene surpris found less genet variat gene regul hs rat relat human though still found eqtl ortholog mani human gene eqtl found data avail ratgtex data portal ratgtexorg enabl new discoveri genet influenc complex trait | D055106;D040641 | T063;T028 |
36,263,803 | pharmacotherapi bipolar disord adult high function autism associ high function autism hfa bipolar disord bd adult subject confirm grow number studi howev identifi treat bd popul clinic challeng requir care assess adequ knowledg disord | D001714;D014150;D001321 | T121;T039;T048 |
36,263,801 | g quadruplex guid rna engin modul crispr base genom regul import develop small moelcul base method modul gene edit express human cell role g quadruplex g biolog system wide studi g guid rna engin perform generat guid rna g form unit g grna demonstr chemic target g grnas hold promis general approach modul gene edit express human cell rich structur divers rnas offer reservoir target small molecul bind thus creat potenti modul rna biolog | D064113;D017394 | T123;T040;T114 |
36,263,785 | regul differ proton state two intim histidin residu reduct half reaction glucos oxidas glucos oxidas gox catalyz oxid glucos mild condit direct convert biolog energi electr energi great potenti applic field enzym biofuel cell glucos biosensor enzymat biofuel cell gox often use anod catalyst improv perform import role two intim histidin residu pdb code ynu gox activ center highlight catalyt oxid glucos still lack systemat examin influenc differ proton state catalyt oxid glucos gox therefor present work gox activ center possibl proton state systemat examin use oniom calcul well influenc remot arg consid calcul reveal intim modul interact glucos substrat isoalloxazin control deproton hydroxyl group bound anomer carbon glucos like control remot arg provid drive forc transfer two electron glucos isoalloxazin fad via long rang electrostat attract like hors special proton serv good helper arg promot occur two proton coupl two electron transfer glucos isoalloxazin activ center gox find provid much insight catalyt reaction gox low ph environ may benefici expand applic gox | D005949;D001674 | T074;T126;T116;T073 |
36,263,779 | nitrosyl mediat reduct ca v surfac express open probabl under attenu vasoconstrict induc nitric oxid l type ca v calcium channel primari gateway ca influx smooth muscl wide regul multipl posttransl modif protein kinas mediat phosphoryl nitric oxid induc nitrosyl howev effect nitrosyl ca v channel function role arteri contractil well understood | D014661;D006973 | T047;T042 |
36,263,778 | histopatholog defin intestin metaplasia lesser curvatur corpus prior helicobact pylori erad risk factor gastric cancer develop helicobact pylori erad shown reduc risk gastric cancer gc number erad therapi case rise howev gc still occur success treatment histolog differ prior erad patient without gc unclear studi investig pre treatment histolog risk factor gc develop follow erad therapi | D016480;D013274;D016481 | T047;T007;T191 |
36,263,757 | safeti evalu perampanel monotherapi first adjunct therapi patient epilepsi need anti seizur medic asm well toler effect monotherapi first adjunct therapi reduc need adjunct asm treat newli diagnos epilepsi reduc number concomit asm patient refractori epilepsi although pivot trial perampanel evalu adjunct use patient refractori seizur open labelr world studi support use firstsecond line set | D000927;D004827 | T033;T121;T047 |
36,263,754 | clinic evalu novel molecular diagnosi kit detect helicobact pylori clarithromycin resist use intragastr fluid although mani helicobact pylori h pylori diagnost method cultur antibiot suscept test import method select effect h pylori erad regimen howev diagnost method complic take sever day therefor develop rapid simpl diagnost method requir erad failur due clarithromycin cam resist also consid studi report clinic evalu point care test poct kit use intragastr fluid novel kit detect h pylori cam resist | D016480;D016481 | T047;T007 |
36,263,753 | relationship healthi lifestyl behaviour subject wellb european observ studi healthi lifestyl relat physic mental health aim studi assess whether differ healthi lifestyl behaviour associ experienti evalu well | D000070497;D014675 | T055;T168 |
36,263,750 | chelat free turn type fluoresc detect trival metal ion trival metal ion essenti element materi life scienc date fluoresc gold standard detect trival metal ion form complex fluoresc chelat ligand lewi base type studi report ph respons fluoresc probe select detect trival metal ion util new chelat free approach use brnsted base type probe moreov x ray structur outer sphere aluminum iii aqua complex coordin fluoresc probe hydrogen bond discov outer sphere complex consist al iii aqua complex proton cation probe show cation cation coordin | D005456;D008670 | T197;T130 |
36,263,745 | dna methyl regul stabil topolog g quadruplex sinc dna methyl alter chromatin state regul gene express elucid regulatori mechan dna methyl respons environment chang cell crucial urgent understand regul dna methyl g quadruplex g regul transcript translat replic although recent suggest g regul methyl detail regulatori mechan remain unclear systemat analys effect g format dna methyl use gs various stabil topolog methyl effici decreas stabil g increas moreov degre methyl suppress also control g topolog furthermor result show possibl regul methyl modul g stabil topolog | D019175;D054856 | T044;T086 |
36,263,722 | synthesi unnatur amino acid pyridin yl carbam via cipe induc carbonyl migrat synthet method unnatur amino acid alway focus extens research due signific bioactiv howev conveni transit metal free catalyz method still demand herein report novel strategi construct unnatur amino acid skeleton via intramolecular rearrang carbam readili avail amin common protect group rearrang could afford varieti amino ester product yield even gram scale reaction reaction mechan studi detail experi theoret calcul complex induc proxim effect cipe pyridyl group shown indispens transform | D002219;D000596 | T123;T121;T116;T109 |
36,263,713 | hierarch microparticl deliv oxaliplatin nlg nanoprodrug local chemo immunotherapi chemo immunotherapi show promis antitumor therapeut outcom mani primari cancer research area focus develop ideal formula enabl potent efficaci chemo immunotherapi combat various cancer reduc system toxic herein present novel hierarch hydrogel microparticl ddp deliv oxaliplatin nlg nanoprodrug local chemo immunotherapi desir featur oxaliplatin prodrug nlg effici load dual drug polymer nanoparticl ddp nps encapsul ddp use microfluid technolog deliv tumor site ddp nps sustain releas ddp retain local reduc system toxic endocytos cancer cell cytotox oxaliplatin nlg could success trigger releas ddp nps chain shatter manner lead immunogen cell death icd tumor cell suppress intratumor immunosuppress treg respect assist immun modul chemotherapeut induc icd could trigger robust system antitumor immun respons present superior synergist antitumor efficaci thus hierarch microparticl could substanti inhibit growth mous subcutan colorect tumor breast tumor colorect tumor larg initi size via synerg chemo immunotherapi show great potenti practic clinic applic oncotherapi | D007167;D015179 | T061;T191 |
36,263,712 | manag outcom salmonella gastroenter era rapid molecular test molecular diagnost provid rapid sensit diagnosi gastroenter compar stool cultur studi seek describ chang medic manag outcom children salmonella gastroenter hospit system adopt molecular diagnost | D012475;D005759 | T047;T007 |
36,263,707 | kcc overexpress exosom medit spinal cord injuri recoveri mice exosom show great potenti treat diseas central nervous system includ spinal cord injuri sci still better engin exosom advantag studi purifi exosom k cl co transport kcc overexpress bone marrow mesenchym stem cell exo kcc investig effect exo kcc neural differenti vitro repair function exo kcc sci mice vivo compar bone marrow mesenchym stem cell bmsc deriv exosom exo exo kcc could better promot neural stem cell differenti neuron amelior function recoveri sci mice acceler neural regener lesion site altogeth engin exo kcc may prove advantag strategi sci treatment | D055354;D013119;D059630;D027981 | T026;T123;T116;T025;T037 |
36,263,706 | synthesi structur studi interact dnahsa antitumor evalu new cu ii complex contain h imidazol yl pyridin amino acid copper complex consid potenti candid anticanc therapi medic applic paper three new cu ii complex cu ipi clo h cui cu ipi l phe h clo h cui cu ipi l val h clo cui ipi h imidazol yl pyridin l phe l phenylalanin l val l valin good amphipath properti synthes character singl crystal x ray diffract result reveal cui four coordin cui cui adopt five coordin tetragon pyramid configur multi spectral method viscos experi molecular dock techniqu show three complex interact dna insert result gel electrophoresi experi indic dna oxid cleav complex concentr depend manner moreov singlet oxygen hydrogen peroxid h superoxid anion radic associ oxid cleavag dna complex also good bind affin human serum albumin hsa mb degrad assay reveal complex could react h form oh fenton like process complex display good antiprolif activ test human cancer cell vitro includ cervic carcinoma cell hela liver cancer cell hepg bel gastric adenocarcinoma cell sgc show lower toxic normal liver cell lo anticanc mechan research reveal cui cui cui arrest cell cycl phase elev intracellular reactiv oxygen speci ros level induc loss mitochondri membran potenti mmp result indic cu ii complex could induc dna damag ros mediat mitochondri dysfunct lead cancer cell apoptosi work provid theoret basi design new low toxic high effici anticanc cu ii complex incorpor biolog metabolit aromat heterocycl ligand | D000970;D056831 | T121;T104;T109 |
36,263,702 | flow driven synthesi calcium phosphat calcium algin hybrid chemic garden system far equilibrium self assembl spatiotempor structur report format calcium algin garden along inorgan hybrid sodium algin solut contain sodium phosphat various composit inject calcium chlorid reservoir viscoelast properti membran develop control inject rate thick amount sodium phosphat besid diffus inorgan hybrid membran constant thick synthes presenc suffici amount sodium phosphat electrochem character membran suggest drive forc ph gradient develop along two side henc cell potenti control addit alkalin sodium phosphat sodium algin solut | D000464;D002130 | T121;T122;T197;T109 |
36,263,697 | viscos aid electromechan porat cell transfect molecul cell porat technolog offer opportun understand activ biolog molecul also investig genet manipul possibl unfortun transfer larg molecul carri huge genom inform challeng demonstr electromechan porat use core shell structur microbubbl generat consist fine microelectrod cover dielectr materi introduc microcav tip could concentr electr field applic electr puls generat microbubbl electromechan stimul cell specif technolog enabl transfect molecul thousand kda even osteoblast chlamydomona general consid difficult inject notabl found transfect effici enhanc adjust viscos cell suspens presum achiev remodel membran cytoskeleton applic approach varieti cell type open numer emerg gene engin applic | D045423;D004560 | T074;T070 |
36,263,688 | rh ii catalyz synthesi h isochromeno b indolizin diazoisochroman imin pyridin rh ii catalyz annul pyridin diazoisochroman imin lead h isochromeno b indolizin present methodolog provid straightforward access wide varieti substitut h isochromeno b indolizin moder good yield complet regioselect | D007212 | T109 |
36,263,672 | fluoro triazol motif peptid electron properti fluoro triazol amino acid scaffold prepar halogen exchang incorpor peptid x ray diffract fluoro triazol motif main observ import local one side negat potenti surfac fluorin atom reveal cylindr shape deform electron densiti | D014230;D005461 | T121;T196;T123;T109 |
36,263,669 | covid vaccin immunogen among chronic liver diseas patient liver transplant recipi meta analysi data coronavirus diseas covid vaccin immunogen among chronic liver diseas cld liver transplant lt patient conflict perform meta analysi examin vaccin immunogen regard etiolog cirrhosi status vaccin platform type antibodi | D000086382;D016031;D008107 | T061;T047;T033;T067 |
36,263,668 | global preval depress anxieti patient hepatocellular carcinoma systemat review meta analysi depress anxieti associ poorer outcom patient hepatocellular carcinoma hcc howev preval depress anxieti hcc unclear aim establish preval depress anxieti patient hcc | D001007;D006528;D003863;D008113 | T184;T191;T041;T048 |
36,263,667 | impact nationwid hepatocellular carcinoma surveil prognosi patient chronic liver diseas studi aim investig effect hepatocellular carcinoma hcc surveil use korea nation liver cancer screen program receipt curat treatment hcc mortal patient chronic liver diseas | D006528;D019694;D008113;D019698 | T047;T191 |
36,263,666 | klca ncc korea practic guidelin manag hepatocellular carcinoma hepatocellular carcinoma hcc fifth common cancer worldwid fourth common cancer among men south korea preval chronic hepat b infect high middl old age current practic guidelin provid use sensibl advic clinic manag patient hcc total expert field hepatolog oncolog surgeri radiolog radiat oncolog korean liver cancer associ nation cancer center korea practic guidelin revis committe revis korean guidelin develop new recommend integr date research find expert opinion guidelin provid use inform direct clinician traine research diagnosi treatment hcc | D006528;D008113;D019694 | T047;T191 |
36,263,665 | patient center health technolog assess perspect engag health technolog assess three patient organ health technolog assess bodi patient engag health technolog assess hta becom increas import past year academ practition literatur produc numer case studi best practic account patient involv practic around world text analyz experi involv institut clinic econom review icer hta review unit state analysi come joint perspect three patient organ lupus alli diseas associ inc lupus foundat america black women health imper well icer suggest meaning patient center engag patient communiti systemat integr throughout review way return disciplin root focus technolog societ ethic impact process requir robust commit involv produc assess relev direct affect | D013673;D010358 | T081;T058;T080 |
36,263,663 | select identifi expos unexpos c c pair human telomer motif structur length depend polymorph motif structur im attract much attent vivo bioactiv wide vitro applic dna base switch herein length depend fold cytosin rich repeat human telomer ccctaa n ccc im n n fulli explor found im im im main form intramolecular monom im structur tetramolecular structur popul im howev im im potenti fold well dimer im structur besid monom one natur hypericin hyp use polymorph select probe recogn im structur interest im im im effici switch hyp fluoresc specif bind outmost c c base pair expos direct solut howev im structur fold way coverag outmost c c pair loop sequenc total unavail hyp bind theoret model indic adapt cation interact contribut hyp recognit toward expos c c pair specif im recognit boost photocatalyt dnazym construct work provid reliabl fluoresc method select explor polymorph im structur | D016615;D004247 | T026;T123;T114 |
36,263,662 | therapeut effect vivo radiodynam therapi rdt lung cancer treatment combin mv photon aminolevulin acid ala object radiodynam therapi rdt use high energi photon beam instead visiblenear infrar light treat deep seat tumor photodynam therapi achiev due low penetr depth laser beam purpos studi investig therapeut effect rdt mv photon beam combin aminolevulin acid ala use mous model approach subcutan cbl mous model kp small cell lung cancer cell line use tumor n random four group observ individu synergist effect ala radiat treatment control untreat n radiat treatment rt n ala n rdt n rt rdt group gy singl fraction deliv tumor use mv photon ala rdt group ala inject dose mg kg tail vein h prior rt tumor respons assess monitor tumor growth use mr maximum standard uptak valu suv max total lesion glycolysi tlg use f fdg petct anim surviv main result rdt achiev statist signific delay tumor growth day post treatment compar ala rt control group p respect signific differ tumor growth ala rt group addit decreas tumor growth observ show synergist effect rdt furthermor rdt signific decreas f fdg uptak suv max tlg day post treatment p respect rdt mice surviv longest treatment group signific rdt mv photon ala result greater tumor control compar control treatment group signific synergist effect also observ rdt preliminari result demonstr effect cancer treatment modal | D000622;D008175 | T123;T121;T116;T109;T191 |
36,263,660 | stabil larg pore flexibl metal organ framework via chemic cross link barrier isoreticular expans flexibl metal organ framework complex breath behavior lead pore closur upon solvent exchang remov show chemic cross link stabil open form flexibl aluminum framework larg pore | D000073396 | T109 |
36,263,655 | circadian clock possibl control point colorect cancer progress review circadian rhythm generat cellular level molecular clock system involv specif gene studi reveal circadian clock disrupt control point cancer progress colorect cancer crc one cancer close associ circadian disrupt present review involv circadian clock crc develop summar abnorm express certain clock gene found patient crc correl clinicopatholog featur also explor period cryptochrom cri sirtuin sirt neuron pas domain protein npas gene report tumour suppressor properti convers cri brain muscl arntlik circadian locomotor output cycl kaput clock timeless may aggrav crc progress find consist requir confirm research circadian schedul also indic advantag chemotherapi treatment patient crc increas maximum toler dose decreas toxic dysfunct molecular clock system disrupt cellular process acceler colon tumorigenesi metabol cell cycl dna damag repair prolifer apoptosi epithelialmesenchym transit stem clock gene network dynam system influenc crc discuss | D057906;D015179 | T040;T191 |
36,263,654 | metal organ framework near infrar luminesc switch determin kaempferol quercetin antenna effect establish reliabl sensit method detect flavonoid kaempferol kae quercetin que import challeng food chemistri pharmacolog numer structur analogu may interfer detect design effici switch fluoresc sens strategi kae que still unachiev stage work switch near infrar nir luminesc sens assay kae que fabric base metal organ framework mof call iqba yb first time fluoresc enhanc mechan analyt serv addit antenna yb lead effici switch nir emiss excit nm meanwhil combin result experi theoret calcul reveal exist hydrogen bond kae que mof skeleton promot energi transfer analyt yb facilit fluoresc enhanc respons develop probe possess excel sens capabl kae que accompani wide linear rang low detect limit short respons time min min use determin kae que content green lake eatabl que sampl satisfactori result | D011794;D000073396 | T121;T127;T109 |
36,263,633 | tunabl dynam optofluid microlen array base droplet microlen array mlas acquir key role micro optic system wide appli field imag process light extract biochem sens display technolog compar solid mlas liquid mlas receiv extens attent due natur smooth interfac adjust howev manufactur tunabl liquid mlas ideal structur still key challeng current technolog paper novel simpl optofluid method demonstr enabl tunabl focus high qualiti imag liquid mlas tunabl droplet fabric self assembl array mlas easili adjust focus form imag display differ focal length tune mlas focus properti rang demonstr chang refract index ri droplet fix size chang adjust flow rate two branch stream also correspond numer apertur mlas rang furthermor mlas function microparticl imag applic also illustr combin mlas object microparticl imag magnifi two time resolut also improv origin basi besid size ri mlas optofluid chip adjust detect sampl differ posit mlas merit high optic perform simpl fabric procedur easi integr good tunabl thus show promis opportun mani applic adapt imag sens | D007909 | T073 |
36,263,632 | ppprd promot prolifer migrat invas lung adenocarcinoma via pkcbrafmekerk signal pathway protein phosphatas pp inhibitor play role tumor progress differ mechan protein phosphatas regulatori subunit ppprd inhibitor pp howev role ppprd tumor mechan action larg unknown purpos present studi investig express function mechan ppprd lung adenocarcinoma luad present studi gepia databas analysi immunohistochemistri demonstr ppprd high express luad tissu express ppprd luad negat correl age patient posit correl th american joint committe cancer stage among patient addit kaplanmei plotter databas analysi show ppprd express associ lower surviv rate patient luad ppprd knockdown signific inhibit luad cell prolifer migrat invas induc luad cell arrest g phase cell cycl mechanist analys reveal ppprd knockdown may inhibit cell prolifer migrat invas inactiv pkcbrafmekerk pathway signal downstream key protein cmyccyclin ecdk mmpmmpvimentin moreov knockdown ppprd suppress tumor growth vivo result show ppprd play import role luad tumorigenesi may serv potenti prognost factor therapeut target luad | D008175;D000077192 | T191 |
36,263,628 | explor histopatholog serum biomark lung adenocarcinoma clinic applic translat opportun review lung cancer repres one common neoplasm main caus cancerassoci death worldwid relationship differ risk factor tobacco main etiolog factor clear establish despit numer advanc achiev diagnosi treatment followup patient life expect patient notabl limit furthermor treatment exempt comorbid frequent neither provid optim control diseas improv qualiti life patient despit possibl perform screen test patient risk implement daili clinic practic complex diagnos advanc stage diseas system radiotherapi chemotherapi treatment slight improv prognosi lung adenocarcinoma repres type lung cancer specif epidemiolog molecular clinic featur thus grow number studi conduct find potenti therapeut target base studi differ molecular pathway improv outcom patient addit broad spectrum serolog immunohistochem genet marker evalu use screen followup patient daili clinic practic unlik tumor current implement earli diagnosi diseas therefor aim present review summar main advanc occur develop serolog histolog marker therapeut implic patient diagnos lung adenocarcinoma explain limit observ analyz futur perspect clinic manag diseas | D000077192;D008175 | T191 |
36,263,625 | novel insight function nmethyladenosin modifi lncrnas cancer review emerg evid suggest nmethyladenosin modif typic rna methyl modif control fate modifi transcript involv pathogenesi various human diseas metabol disord nephropatholog osteoarthr malign tumour long noncod rnas lncrnas transcript gt nt length also indic involv various diseas particip process epigenet modif transcript altern posttransl regul recent studi reveal lncrnas wide modifi critic role various cellular process associ numer disord particular human cancer present review first examin function modif lncrnas includ chang lncrna structur mediat transcript regul affect mrna precursor splice regul lncrna stabil translat furthermor regulatori mechan mamodifi lncrnas cancer summar uptod detect method predict tool identifi site lncrnas present addit viewpoint potenti futur direct field discuss includ accur detect method role lncrnasencod micropeptid cancer relationship mamodifi lncrnas tumour microenviron mamodifi lncrnas potenti biomark therapeut target human cancer | D062085;D009369 | T123;T191;T114 |
36,263,624 | short term bystand effect radiat murin submandibular gland mani patient treat head neck cancer experi salivari gland hypofunct due radiat damag understand mechan cellular damag induc radiat treatment import order design method radioprotect addit crucial recogn indirect effect irradi system respons may alter saliva secret studi radiat deliv murin submandibular gland smgs bilater use cs gamma ray irradi unilater use small anim radiat research platform sarrp analysi h show dynam chang mrna protein express smgs irradi bilater unilater irradi use sarrp caus similar chang irradi smgs well signific target bystand effect non irradi contralater smgs | D013363;D002588 | T131;T023;T196 |
36,263,622 | circular rnas endometri carcinoma review one lead caus death women western develop countri endometri carcinoma ec common gynecolog malign tumor serious threaten women health recent year trend emerg ec manifest younger women overal incid gradual rise circular rnas circrna novel endogen transcript limit abil encod protein due coval closedloop structur differ type rna grow bodi evid demonstr circrna fulfil import role lung cancer gastric cancer breast cancer ec malign tumor type affect occurr develop malign varieti pathway demonstr potenti circrna molecular biomark diagnosi treatment prognosi malign tumor purpos present review summar current understand biogenesi effect circrna discuss express function under mechan circrna ec order identifi potenti novel biomark | D013274;D016889 | T191 |
36,263,620 | upar beyond regul physiolog function orchestr role cancer review urokinasetyp plasminogen activ receptor upar serv receptor upa upaupar complex initi extracellular matrix degrad cascad cancer aberr elev upar express associ invas metastasi well cancer prolifer surviv therebi render upar effect marker prognosi target therapi although upar transient express limit amount normal tissu certain noncanc patholog process under mechan overlap tumorigenesi present review summar fundament function signal pathway target therapeut strategi particular immunotherapi target upar well differenti role noncanc cancer tissu object evalu whether classic molecular pathway endur research valu futur studi | D055293;D009369 | T129;T191;T116;T192 |
36,263,619 | pdl mediat tripleneg breast cancer evolut via regul tamm polar tumorassoci macrophagesmtyp tamm play key role metastasi angiogenesi cancer consid critic target cancer treatment howev remain unclear whether program deathligand pdl pdl inhibitor inhibit tumor progress via target tam present studi demonstr pdl signific inhibit ilinduc tamm polar vitro moreov pdl inhibit epithelialmesenchym transit emt process stem tripleneg breast cancer tnbc cell mediat via revers tamm polar therefor inhibit migrat angiogenesi tnbc cell furthermor pdl prevent stat phosphoryl nuclear transloc result arrest tamm polar vivo experi demonstr pdl reduc number lung metastas without affect tumor growth moreov pdl reduc express level tamm emt stem vascular marker tumor tissu summari data suggest pdl play vital role antimetastasi antiangiogenesi tnbc vitro vivo via inhibit tamm polar find may thus provid novel therapeut strategi clinic refractori tnbc | D064726 | T191 |
36,263,616 | role dna damag repair precis target therapi renal cancer review primari subtyp renal cell carcinoma rcc includ clear cell papillari chromophob rcc rcc occur often due loss von hippellindau vhl accumul lipid glycogen rcc cell may exhibit sensit disrupt normal metabol homolog recombin gene defect although applic moleculartarget drug tyrosin kinas inhibitor immun checkpoint inhibitor recommend treatment advanc rcc target dna damag repair ddr signal pathway involv synthet lethal effect investig howev although achiev made explor role ddr gene rcc progress associ systemat summar poli adpribos polymeras parp inhibitor use tumor brca dna repairassoci mutat parp famili enzym perform posttransl modif function particip ddr cell death inhibitor parp ataxia telangiectasia mutant gene polymeras serv key role treatment specif rcc subtyp parp may serv import biolog marker predict therapeut effect immun checkpoint inhibitor evalu prognosi patient ccrcc polybromo mutat therefor role ddr pathway rcc progress treatment may hold promis treatment certain specif type rcc | D002292;D007680 | T191 |
36,263,615 | transmiss role symptomat asymptomat covid case model studi coronavirus diseas covid asymptomat case hard identifi imped transmiss estim valu covid transmiss worth elucid key assumpt model studi popul base surveil network collect data confirm case day follow asymptomat case age stratifi compartment model contain contact inform built estim transmiss symptomat asymptomat covid case differ transmiss symptomat asymptomat case depend age distinct middl age group asymptomat case lower transmiss rate symptomat case ci asymptomat case miss detect averag proport asymptomat case ci simul demonstr burden asymptomat transmiss increas epidem continu could potenti domin total transmiss transmiss asymptomat covid case high asymptomat covid case play signific role outbreak | D000086382;D058872 | T047;T067 |
36,263,611 | lipocalin activ nlrp inflammasom via lpsinduc nfb signal play role proinflammatori regul murin macrophag lipocalin lcn high express sever infecti inflammatori disord howev express level under mechan lcn inflammatori bowel diseas ibd poor understood current studi use murin ibd model lpsactiv macrophag elucid role lcn ibd pathogenesi level lcn protein concentr confirm much higher colon colitisinduc mice compar healthi mice use immunohistochemistri western blot elisa assay vitro level lcn raw macrophag increas signific follow lps stimul diminish mark upon use nfbspecif inhibitor assembl nod lrr pyrin domaincontain protein nlrp inflammasom inhibit lcn express knock evidenc decreas nlrp asc caspas activ furthermor secret matur il attenu lcn silenc lpsstimul macrophag togeth result suggest lcn direct upregul nlrp inflammasom complex via nfb activ respons stimul macrophag lps act proinflammatori regul macrophag activ modul nfb activ overal lcn may serv promis target prevent treatment ibd | D058847;D015212 | T123;T047;T116 |
36,263,610 | placent proteom lateonset fetal growth restrict fetal growth restrict fgr occur fetus reach genet program intrauterin potenti growth affect pregnanc condit one lead caus perinat mortal morbid associ obstetr neonat complic placent dysfunct fgr caus impair transfer nutrient oxygen mother develop fetus matern adapt placent insuffici may also play role pathophysiolog fgr present studi aim compar proteom placenta women physiolog cours pregnanc eutroph fetus estim fetal weight efw th percentil control group women late fgr efw th percentil diagnos week pregnanc accord delphi consensus studi group u mannwhitney test use compar two independ group r spearman correl coeffici signific test use assess exist relationship analyz measur paramet p consid indic statist signific differ test show presenc differ protein respons regul gene transcript control inhibit activ proteolyt enzym regul trophoblast prolifer angiogenesi inflammatori respons fgr placent proteom detect protein most involv respons oxid stress cellular oxid detox apoptosi hemostat catabol process energi transduct protein interact cell prolifer differenti intracellular signal present studi use chromatograph massspectrometri compar placent proteom profil pregnanc complic lateonset fgr normal pregnanc compar analysi proteom normal fgr placenta show signific differ research need clarifi matern fetal adapt fgr | D005317;D006490 | T121;T046 |
36,263,609 | electro oxid induc cross coupl quinoxalinon sodium sulfin synthes sulfonyloxyl quinoxalin function quinoxalinon synthet biolog appeal howev c function quinoxalinon report via environment friend approach herein disclos c sulfonyl quinoxalinon via develop electrochem oxid coupl strategi synthes sulfonyloxyl quinoxalin appli protocol quinoxalin one sodium sulfin start materi wide rang sulfonyloxyl quinoxalin deriv obtain moder good yield good function group toler mild condit without addit oxid util methodolog sulfonyloxyl handl demonstr trough gram scale prepar synthesi substitut quinoxalin base bioactiv molecul respect | D011810;D012964 | T123;T196;T034;T109 |
36,263,604 | drug base mobilis mesenchym stemstrom cell improv cardiac function post myocardi infarct unmet need treatment prevent progress cardiac dysfunct follow myocardi infarct mesenchym stemstrom cell mscs investig cardiac repair howev cultur expans prior transplant hinder home repar abil pharmacolog mobilis could altern msc transplant report endogen mscs mobilis circul day post myocardi infarct male lewi rat mobilis signific increas use combin fda approv drug mirabegron adrenoceptor agonist amd cxcr antagonist blind cardiac magnet reson imag analysi show treat group increas left ventricular eject fraction decreas end systol volum week post myocardi infarct mobilis group signific decreas plasma il tnf level decreas interstiti fibrosi increas border zone blood vessel densiti condit medium blood deriv mscs support angiogenesi vitro shown tube format wound heal assay data suggest novel pharmacolog strategi enhanc myocardi infarct induc msc mobilis improv cardiac function myocardi infarct | D045164;D059630;D009203 | T061;T047;T025 |
36,263,598 | extent social support masteri mediat associ childhood maltreat depress sequenti causal mediat analysi studi aim examin independ role various childhood maltreat cm subtyp develop depress quantifi joint mediat effect social support masteri associ subtyp cm depress examin addit contribut masteri beyond effect oper social support relationship | D003865;D002649 | T048 |
36,263,595 | strongyloidiasi diagnost therapeut dilemma hyperinfect patient case seri helminth infect caus strongyloid stercorali widespread tropic region rare european countri unfamiliar diseas diagnost obstacl could contribut lethal outcom frequent use corticosteroid covid pandem could increas signific aim retrospect descript studi explor diseas pattern discuss clinic dilemma patient stercorali hyperinfect treat univers hospit infecti diseas dr fran mihaljevi zagreb croatia five immunosuppress patient treat due strongyloidiasi develop hyperinfect patient male median year four immunosuppress corticosteroid although ileum resect could trigger one one rituximab diagnosi establish median month symptom durat accident patient visual parasit gastricduoden mucosa four case bronchial aspir one patient cachect four five sever hypoalbuminemia suffer secondari bacterialfung infect despit combin antibiot antifung antihelmint therapi three five patient die fail clear live parasit stool sampl conclud signific delay diagnosi lack clinic suspicion observ among patient sever clinic present strongyloidiasi although beyond diagnost recommend strongyloidiasi earli upper gastrointestin endoscopi mucos sampl analysi could expedit diagnosi sever immunosuppress patient persist viabl parasit stool despit antihelmint therapi investig | D013322;D000086382;D017171;D000871 | T121;T047;T204;T067 |
36,263,578 | assess palpit complaint patient benign paroxysm posit vertigo detect cardiac arrhythmia vertigo attack along resolut vertigo treat arrhythmia defin cardiac vertigo caus palpit develop follow attack non cardiac vertigo unknown aim investig effect benign paroxysm posit vertigo bppv cardiac conduct system evalu patient palpit complaint use hour ambulatori ecg holter monitor | D065635;D015716 | T060;T047 |
36,263,577 | evalu effect cpap treatment voic obstruct sleep apnea object subject voic analyz obstruct sleep apnea osa multifactori diseas common among sleep relat respiratori disord studi aim compar object subject voic analysi result patient cpap treatment indic polysomnographi perform sleep disord center start cpap treatment st month rd month treatment | D045422;D020181 | T061;T047 |
36,263,576 | degen inflammatori musculoskelet disord updat hot topic diagnost intervent imag purpos review present latest innov current topic musculoskelet diagnosi intervent imag focus degen inflammatori diseas | D009140;D011871 | T047;T091 |
36,263,575 | mobil comput tomographi scanner trailer field hospit experi studi aim examin use mobil comput tomographi ct trailer field hospit | D008952;D014057 | T060;T073;T093 |
36,263,574 | rescu intracrani stent acut ischem stroke preliminari vietnames studi case acut ischem stroke ai caus intracrani larg vessel occlus rescu intracrani stent ris recent emerg treatment option achiev recan mechan thrombectomi mt fail howev studi date report benefici outcom ris goal analyz whether ris use improv prognosi patient month post treatment | D000083242;D020521;D002545 | T047;T046 |
36,263,573 | protect effect short term thymoquinon administr central nervous system cisplatin induc neurotox studi perform investig potenti benefici effect thymoquinon tq brain tissu base biochem histopatholog analys cisplatin cis treat rat central nervous system cns neurotox | D002945;D016875 | T121;T197;T116;T123 |
36,263,572 | serum pnf h level first six hour experiment mild traumat brain injuri rat mild traumat brain injuri mtbi case normal ct scan account vast major tbi patient aim studi investig cours serum phosphoryl neurofila heavi chain pnf h level first six hour trauma rat experiment mtbi | D001924;D000070642 | T037 |
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