PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,263,571 | neuroprotect effect amantadin experiment acut carbon monoxid poison amantadin known neuroprotect effect mani neurolog diseas studi aim investig neuroprotect effect amantadin rat expos carbon monoxid co poison | D002249;D018696 | T121;T169;T037 |
36,263,570 | effect intermitt aerob train exercis capac pulmonari function gait paramet asthmat children cerebr palsi random control trial evid exercis train program effect improv aerob capac musculoskelet abnorm qualiti life asthmat children cerebr palsi cp therefor effect intermitt aerob train exercis capac pulmonari function gait paramet asthmat cp children evalu current studi | D002547;D001249 | T019;T047 |
36,263,569 | normat valu rest length pectorali minor muscl among individu asymptomat shoulder south bengaluru cross section pilot studi aim studi determin normat valu rest length pectorali minor muscl among male femal asymptomat shoulder south bengaluru | D012782;D010369 | T023;T029 |
36,263,568 | evalu educ hydrat sodium status cool environ among chines athlet aim studi find signific sever factor paramet urin test blood test final aim evalu percentag athlet studi sampl regard hydrat level | D003681;D012964 | T123;T047;T196;T034 |
36,263,564 | preval cardiovascular diseas osteoarthr obes popul hail region saudi arabia aim studi analyz link chronic diseas like cardiovascular diseas cvd osteoarthr oa obes popul saudi arabia hail region | D002318;D010003;D006973;D020370 | T047 |
36,263,563 | high absi valu associ af recurr af ablat prospect singl center studi studi shown obes independ risk factor develop atrial fibril af bodi mass index bmi waist circumfer wc becom accept indic obes howev bmi suffici locat fat muscl distribut pattern fat muscl ratio bodi bodi shape index absi base wc adjust height weight absi wc bmi x height high absi associ higher caus cardiovascular cancer mortal bmi wc waist height ratio aim investig absi score characterist patient undergo rf radiofrequ ablat af | D001281;D017115 | T061;T047;T046 |
36,263,562 | comparison plasma salivari meteorin like protein level patient newli diagnos type diabet treat metformin present studi compar plasma salivari metrnl level patient newli diagnos type diabet treat metformin three month healthi volunt group immunohistochem analyz metrnl salivari gland | D008687;D003924 | T121;T047;T109 |
36,263,561 | vitamin b folic acid vitamin iron ferritin magnesium hbac level patient diabet mellitus dental prosthesi diabet patient may vitamin defici import follow complic diabet various reason may benefici includ use dental prosthesi among paramet investig caus vitamin defici manag follow diabet mellitus aim investig associ serum vitamin b folic acid hydroxyvitamin ferritin iron magnesium hbac level diabet patient without remov dental prosthesi non diabet patient prosthesi | D014806;D008687;D003920;D017266 | T121;T047;T074;T109 |
36,263,560 | role triglycerid glucos index determin subclin atherosclerosi patient primari hypertens current studi aim examin relationship triglycerid glucos tyg index subclin atherosclerosi patient primari hypertens | D050197;D006973 | T047;T046 |
36,263,559 | diagnost perform quantit signal intens measur magnet reson imag distinguish cerebellopontin angl meningioma acoust schwannoma studi investig magnet reson imag measur differenti cerebellopontin angl cpa meningioma vestibular schwannoma vs | D002528;D002530;D008279;D008577;D008579;D009464 | T030;T060;T191;T059;T170 |
36,263,558 | palmit acid musa paradisiaca induc apoptosi caspas human oral squamous cell carcinoma despit apoptosi process conserv cancer cell develop mechan inhibit apoptosi alter anti apoptot molecul inactiv pro apoptot aim studi determin palmit acid musa paradisiaca var sapientum l kunz mp stem extract human oral squamous cell carcinoma hoscc caspas | D028521;D002294;D009062;D006258 | T168;T191;T002 |
36,263,557 | lung cancer screen studi smoke popul kunm yunnan china central tobacco produc region larg smoke popul increas incid lung cancer recent year studi aim understand incid lung cancer characterist lung nodul low dose comput tomographi ldct scan chest long term smoke popul kunm | D008175;D000230 | T191 |
36,263,556 | characterist abnorm subject screen tumor marker among middl age elder peopl weihai area base huimin polici weihai social secur bureau project aim investig feasibl screen screen serum tumor marker tm middl age elder popul weihai area accord joint mode examin institut clinic depart oncolog provid dynam follow subject earli intervent abnorm tumor screen high risk popul cut pathogen pathway cancer improv earli diagnosi cancer enhanc cure rate | D014408;D008175 | T123;T191 |
36,263,555 | valu potenti immunohistochem biomark clinicopatholog find predict respons neoadjuv chemotherapi breast cancer follow neoadjuv chemotherapi nac breast cancer bc complet treatment respons achiev patient treatment respons limit other predict non respond patient prevent exposur advers effect associ chemotherapeut agent delay select treatment modal studi aim identifi predict factor relat tumor regress patient bc receiv nac | D001943;D020360 | T061;T191 |
36,263,554 | level public awar cancer hail saudi arabia cancer group diseas character uncontrol cell divis abnorm cell result death treat well cancer consid lead caus mortal throughout globe import barrier increas life span studi conduct assess awar among graduat studi univers hail relat cancer | D007722;D009369 | T053;T191 |
36,263,553 | cancer inform overload may crucial determin adjuv aromatas inhibitor adher medic non adher lead prevent caus death among cancer patient aim investig whether onlin search cancer treatment creat inform overload determin effect onlin search treatment adher postmenopaus breast cancer bc patient receiv adjuv aromatas inhibitor ai treatment | D047072;D001943 | T121;T191 |
36,263,552 | sever vitamin defici associ endotheli inflamm healthi individu even absenc subclin atherosclerosi vitamin benefici effect involv cardiovascular system studi date investig associ serum endocan level biomark endotheli inflamm vitamin level absenc subclin atherosclerosi detect carotid intima media thick cimt healthi individu | D014808;D050197 | T047;T046 |
36,263,551 | effect l thyroxin treatment ventricular dysfunct pulmonari arteri stiff patient subclin hypothyroid studi aim evalu chang biventricular function pulmonari arteri stiff pas patient subclin hypothyroid sh euthyroid achiev l thyroxin therapi | D059289;D007037;D018754 | T047;T046 |
36,263,550 | ventricular arteri coupl assess pwvgls ratio hypertens patient physiolog interact left ventricl lv arteri system defin ventricular arteri coupl vac facilit optim volum cardiac work cardiovascular perform aim studi evalu benefit pwvgls ratio associ vascular cardiac perform paramet hypertens patient compar age match healthi control | D006973;D059289 | T047;T046 |
36,263,549 | relationship vitamin defici thrombus load patient st elev myocardi infarct clinic studi detect increas thrombot event vitamin defici note relationship vitamin thrombosi studi aim evalu relationship serum vitamin level coronari thrombus burden | D000072657;D062645;D013927;D009203;D014808;D003328 | T061;T047;T046 |
36,263,548 | percutan revascular atherosclerot renal arteri stenosi meta analysi studi investig whether medic therapi alon effect safe percutan revascular pr patient atherosclerot renal arteri stenosi ara | D012078;D050197;D020521 | T047;T046 |
36,263,547 | snapshot geriatr rehabilit one year experi frailti common condit older adult character multimorbid physic weak nutrit deficit frailti detect earli prehabilit treatment could reduc incid disabl | D018737;D000073496 | T184;T040;T033;T081;T046 |
36,263,546 | vessel seal system vs convent knot tie hilar dissect live donor hepatectomi prospect random doubl blind studi lt becom gold standard treatment mani liver diseas especi chronic liver diseas common seen problem even donor develop major complic live donor hepatectomi ldh persist drainag lymphat fluid hepatectomi site drain caus extens hospit consequ loss workforc knowledg studi yet publish compar lvss convent knot tie method hilar dissect import stage ldh procedur aim prospect compar outcom two treatment method | D006498;D019520 | T061;T098 |
36,263,545 | expect pco calcul pcohco formula central venous blood gas sampl mix acid base disord essenti identifi domin disord either metabol respiratori calcul expect partial carbondioxid pco valu obtain arteri blood gas sampl give clue physician main disord sever formula calcul expect pco practic use requir arteri blood gas sampl aim studi investig whether expect pco could calcul simpl formula ad bicarbon hco valu obtain central venous blood gas sampl | D001639;D000137 | T033;T121;T196;T197 |
36,263,544 | impact covid pandem ibd surgeri singl center experi spread covid pandem forc nation healthcar system reorgan almost surgic servic order maintain adequ therapeut offer general surgeri depart fondazion policlinico gemelli rome surgic procedur progress reduc provid bed personnel covid aim studi analyz effect one year covid pandem inflammatori bowel diseas ibd surgeri cohort patient evalu post oper short term complic | D000086382;D015212;D003093 | T047;T067 |
36,263,543 | factor aggrav acn vulgari covid pandem china web base cross section survey acn vulgari common skin diseas worldwid throughout covid pandem mani patient acn complain worsen symptom investig design survey impact covid regul acn guid patient acn symptom manag pandem | D000086382;D000152 | T047;T067 |
36,263,542 | efficaci anticytokin treatment ad corticosteroid patient covid associ pneumonia hyperinflamm singl center experi pneumonia hyperinflammatori state relat covid infect fatal clinic condit without definit treatment modal interleukin interleukin target therapi propos treatment option studi conduct investig efficaci anakinra tocilizumab ad corticosteroid patient covid associ pneumonia hyper inflammatori syndrom tertiari clinic center | D000086382 | T047;T067 |
36,263,541 | effect lymphocyt blood level mortal covid patient intens care unit follow lymphocyt import cell defend human bodi viral pathogen studi aim investig relationship lymphocyt blood level patient surviv covid patient hospit intens care unit | D000086382 | T047;T067 |
36,263,540 | impact covid pandem hpv vaccin coverag general popul plwhs march world health organ declar novel coronavirus covid outbreak global pandem covid pandem impact health servic includ immun program consequ reduct vaccin coverag categori prevent vaccin prevent diseas strong recommend | D000086382;D000079263;D030361;D053918 | T129;T121;T116;T067;T047 |
36,263,539 | evalu factor associ trust telemedicin patient inflammatori bowel diseas covid pandem multicent cross section survey telemedicin tm power impact recent year particular manag chronic diseas inflammatori bowel diseas ibd know patient expect concern essenti increas confid mode medic care | D000086382;D017216;D015212 | T047;T058;T067 |
36,263,538 | safeti inositol supplement patient take lithium valproic acid pilot clinic studi mood stabil like lithium li valproic acid vpa act via cellular deplet inositol central nervous system cns howev deplet also involv peripher tissu thus expos patient various side effect preclin clinic studi reveal effect inositol supplement recov patholog condit nevertheless risk reduc effect pharmacolog therapi rais inositol level cns still repres matter concern studi add new insight aspect highlight safeti tailor dosag inositol patient take li vpa | D007294;D014635 | T121;T127;T109 |
36,263,537 | pharmaci manag patient coronari heart diseas mental disord aim studi find entri point pharmaceut manag accord situat patient coronari heart diseas psycholog disord | D001523;D003327;D010604 | T057;T047;T091;T048 |
36,263,536 | distribut chronic hepat c genotyp evalu clinic factor affect direct act antivir treatment respons western black sea region turkey chronic hepat c chc substanti global public health issu signific variat countri genotyp differ sustain viral respons svr essenti reduc complic associ chc achiev patient via direct act antivir daa present studi aim determin genotyp distribut patient chc region svr daa therapi patient | D019698;D047028 | T047;T109 |
36,263,535 | design silico studi synthesi vitro evalu n h pyrazol yl h benzo imidazol diamin deriv potenti pancreat lipas inhibitor anti obes activ aim studi design n h pyrazol yl h benzo imidazol diamin deriv evalu anti obes activ | D008049;D003959 | T121;T126;T116;T109 |
36,263,534 | molecular analysi antibiot resist identif aerob bacteria isol pleural fluid obtain patient pleural effus common clinic condit due various etiolog caus infecti pleural effus seen patient studi follow patient admit hospit diagnos pleural effus report aim investig preval bacteria isol patient pleural effus antibiot resist profil | D003091;D010996 | T047;T195;T116 |
36,263,533 | relationship intracoronari thrombus burden atherogen index patient st elev myocardi infarct increas coronari thrombus load strong predictor advers cardiovascular cv outcom identifi predictor intracoronari thrombus burden may contribut manag st segment elev myocardi infarct stemi aim evalu relationship atherogen index ati coronari thrombus burden patient present stemi | D000072657;D003328;D062645;D009203 | T061;T047 |
36,263,532 | manag small bowel obstruct sbo older adult year propens score match analysi predict factor un success non oper manag nom small bowel obstruct sbo common emerg older patient appropri treatment strategi still matter debat aim studi compar non oper manag nom vs surgic procedur patient year sbo | D007415 | T047 |
36,263,531 | clinic characterist alcohol hyperlipidemia etiolog complex type acut pancreat aim studi elucid clinic characterist alcohol hyperlipidem etiolog complex acut pancreat | D010195;D006949 | T033;T047;T046 |
36,263,530 | multicent intern observ studi qualiti life accept vagin contracept ring contain etonogestrelethinylestradiol mg six month use current post market studi aim analyz women menstrual bleed intens vagin infect qualiti life paramet use contracept vagin ring ornibel | D003271;D003274 | T121;T122;T074 |
36,263,529 | fertil protect effect taxifolin cisplatin induc ovarian damag aim studi investig protect effect taxifolin ovarian damag reproduct dysfunct creat cisplatin administr | D002945;D005299 | T039;T121;T197 |
36,263,528 | model pregnanc rate ivf et patient infertil endometriosi object present studi examin clinic factor influenc pregnanc rate infertil patient endometriosi establish predict model | D004715;D007247 | T033;T047;T191;T046 |
36,263,527 | novel predictor metabol risk patient polycyst ovari syndrom could viscer adipos index polycyst ovari syndrom pcos common endocrinolog disord women reproduct age often accompani high androgen level irregular menstrual cycl polycyst ovari addit patient pcos also present increas abdomin adipos tissu insulin resist recent gender specif mathemat formul call viscer adipos index vai wide use assess cardiometabol risk studi aim compar vai valu patient pcos patient idiopath hirsut ih control group | D011085;D007333;D002318;D024821 | T047;T046 |
36,263,526 | testicular microdissect follow fail sperm aspir singl center experi azoospermia caus infertil subgroup infertil men sperm retriev techniqu includ testicular sperm aspir tesa microscop testicular sperm extract mtese wide use studi review find regard mtese perform follow negat tesa outcom | D053625;D053713 | T061;T058;T047 |
36,263,525 | effect variant rs fut gene anthropometr metabol paramet caucasian obes popul obes subject genet variant fut gene could impli metabol disord aim present investig evalu associ snp rs fut gene differ obes marker | D009765;D005647 | T047;T126;T116 |
36,263,507 | current develop futur challeng microplast detect techniqu bibliometr base analysi review microplast consid new type pollut marin environ attract widespread attent worldwid recent year plastic particl particl size less mm usual defin microplast similar size plankton marin organ easili ingest microplast threaten higher organ even human health food chain current studi focus investig abund microplast environ howev due limit analyt method instrument number microplast environ easili lead overestim underestim microplast environ differ detect techniqu investig current status hot spot research trend microplast detect techniqu review analyz paper relat microplast detect use bibliometr softwar citespac cooc total articl analyz span contribut cooper differ countri institut field analyz detail topic form two main import network cooper intern cooper common pattern topic various analyt method topic discuss keyword cluster analysi among fluoresc ftir micro raman spectroscopi common use optic techniqu detect microplast identif microplast also achiev combin techniqu mass spectrometrytherm crack gas chromatographi howev techniqu still limit appli environment sampl provid detail analysi detect microplast differ environment sampl list challeng need address futur | D014874;D004785 | T131 |
36,263,494 | diagnosi treatment prevent nutrit anemia children recommend joint committe pediatr hematolog oncolog chapter pediatr adolesc nutrit societi indian academi pediatr anemia children signific public health problem countri comprehens nation nutrit survey provid evid childhood anemia due under nutrit defici nation famili health survey report increas preval anemia five age group last year clear exist public health program decreas preval anemia shown desir result henc need develop nation accept guidelin diagnosi treatment prevent nutrit anemia | D005494;D014806;D000740;D018798;D000748;D006405 | T047;T091 |
36,263,456 | synthesi applic thiocarbam via thiol dioxazolon modifi lossen rearrang thiocarbam could synthes green solvent via thiol dioxazolon modifi lossen rearrang transit metal free addit free mild condit polythiocarbam prepar excel self heal shape memori properti show great potenti develop function materi | D013859;D013438 | T109 |
36,263,452 | effect amino acid sequenc intact filgrastim multimod mass spectrometri topdownr therapeut protein known biolog import grow class drug treatment seri human ailment amino acid sequenc variant therapeut protein affect safeti efficaci top mass spectrometri well suit sequenc analysi intact therapeut protein fine tune tandem mass spectrometri msms fragment condit essenti maxim amino acid sequenc coverag often time consum use topdownr autom integr multimod approach systemat assess high mass accuraci msms fragment paramet character filgrastim kda recombin human granulocyt coloni stimul factor use treat neutropenia total differ msms condit systemat test includ follow paramet protein charg state hcd cid collis energi etd reaction time etd supplement activ uvpd activ time stringent accur evalu annot msms data achiev requir fragment ion mass error ppm consid reproduc n c termin fragment ion exclud intern fragment ion assign report first ethcd uvpd msms analysi intact filgrastim two techniqu combin result amino acid sequenc coverag combin test fragment mode obtain near complet amino acid sequenc coverag intact filgrastim | D053719;D020539 | T063 |
36,263,443 | nutrit intak cycl race train condit profession male cyclist type diabet studi sought detail compar ride nutrit practic group profession cyclist type diabet td train race condit observ seven male profession road cyclist td age year hba c mmolmol vo max mlkg min pre season train union cyclist international multi stage road cycl race tour slovenia ride nutrit interstiti glucos perform variabl quantifi compar two event ride energi intak similar train race condit p carbohydr major sourc fuel event exercis rate gh gh p respect protein consumpt higher train gh race ride gh p similar amount time spent within euglycaem rang mgdl train vs race p data provid new inform ride nutrit intak profession cyclist td differ stage competit season | D001642;D003922 | T056;T047 |
36,263,375 | coronavirus host genom studi south africa covigen sa host genet factor known modifi suscept sever outcom covid vari across popul howev continent african yet adequ repres studi despit import genet factor understand africa respons pandem describ develop research resourc coronavirus host genom studi south africa known covigen sa multicollabor strateg partnership design provid harmonis demograph clinic genet inform specif black south african covid particip recruit date preliminari result sar cov posit particip four particip studi show femal sever diseas peopl live hiv resourc aim provid insight host genet factor relev african ancestri popul use genom wide associ test target sequenc import genom loci project promot enhanc partnership build skill develop resourc need address covid burden associ risk factor south african communiti | D000086382 | T047;T067 |
36,263,374 | preval knowledg attitud predictor waterpip smoke among school adolesc saudi arabia cross section studi design investig preval knowledg attitud predictor waterpip wp smoke among intermedi secondari school adolesc kingdom saudi arabia ksa self administ anonym questionnair use collect data demographi wp smoke status pattern arab version global youth tobacco survey tool instrument assess knowledg attitud toward wp smoke patient health questionnair phq also use descript inferenti statist techniqu use model wp smoke behavior conduct use logist regress total male student particip studi preval current wp cigarett smoker respect total popul student misconcept wp smoke less harm cigarett signific associ p demograph factor age school stage resid parent educ level wp smoke status observ pleasur social happi repres primari motiv initi wp smoke major student misconcept wp health effect believ smoke wp could eas anxieti caus less harm less addict properti compar cigarett model suggest signific predictor wp smoke cigarett smoke depress attitud index current find warrant research offici health program promot educ initi regard wp smoke | D000073867 | T055 |
36,263,329 | case report ketotestosteron may potenti advanc bone age seen case wiedemann steiner syndrom wiedemann steiner syndrom wss genet disord associ array clinic phenotyp includ advanc bone age short statur ketotestosteron kt member group known oxygen c androgen implic prematur adrenarch | D000015;D008607 | T019;T048 |
36,263,328 | impact bmi long term anthropometr metabol outcom girl idiopath central precoci puberti treat gnrhas gonadotropin releas hormon analog gnrhas effect increas final height children idiopath central precoci puberti icpp howev previous year transient metabol complic describ treatment long term outcom data studi aim evalu efficaci gnrhas clarifi bodi mass index bmi diagnosi icpp could influenc long term outcom | D011629 | T047 |
36,263,327 | enhanc anti cancer effect oestrogen progesteron co therapi colorect cancer male although ovarian sex steroid could protect role colorect cancer crc women littl current known potenti anti tumorigen effect men henc studi measur therapeut effect oestradiol e andor progesteron p azoxymethan induc crc male mice divid n micegroup negat nc posit pc control e gkgday five timesweek p mgkgday five timesweek monotherapi concurr ep sequenti ep co therapi group hormon inject intraperiton design group four consecut week similar treatment protocol e nm andor p nm also use sw sw human male crc cell line pc group show abund colon tumour alongsid increas colon tissu testosteron level androgen ar oestrogen er receptor wherea e p level er progesteron receptor pgr decreas signific compar nc group e p monotherapi equal increas erpgr pcytochrom ccaspas reduc testosteron level inhibit erar ccndsurvivin promot apoptosi relat pc group co therapi protocol also reveal better anti cancer effect enhanc modul colon sex steroid hormon receptor ep promin protocol vitro ep regimen show highest increas number sw fold sw fold cell sub g phase cell cycl ep co therapi also disclos lowest percentag viabl sw cell fold whilst co therapi protocol equal show greatest sw apoptot cell number fold relat untreat cell moreov co therapi regimen reveal maxim inhibit cell cycl induc cell surviv marker arer alongsid highest express cell cycl suppressor pro apoptot molecul erpgr cell line conclus crc associ abnorm level colon sex steroid hormon alongsid aberr protein express receptor anti cancer effect e p monotherapi equal combin protocol show boost tumoricid action crc male possibl promot er pgr mediat androgen depriv togeth inhibit er regul oncogen pathway | D011471;D015179 | T191 |
36,263,326 | role oxid lipid speci insulin resist nash children last two decad nonalcohol fatti liver diseas nafld emerg common hepat diseas pediatr main owe rise preval pediatr obes epidemiolog studi shown progress increas nafld preval associ obes also chang dietari habit experienc age group character increas intak ad sugar certain fatti acid review articl focus effect oxid fatti acid deriv linol acid arachidon acid pathogenesi progress nafld youth | D065626;D007333 | T047;T046 |
36,263,325 | urinari il associ arteri stiff patient type diabet diabet kidney diseas dkd shown associ excess risk cardiovascular death inflamm consid central type diabet td pathophysiolog inflamm marker link cardiovascular diseas serum urinari il level signific elev patient td howev whether interleukin il associ sever arteri stiff remain determin studi examin relationship il level puls wave veloc pwv reflector arteri stiff patient td | D059289;D003924 | T047;T046 |
36,263,324 | associ met ir index preval gallbladd stone age first gallbladd stone surgeri us adult cross section studi purpos studi assess correl metabol score insulin resist met ir index gallbladd stonepreval us adult well age first gallbladd stone surgeri | D007333;D042882 | T046;T031 |
36,263,323 | explor anti androgen therapi hormon depend prostat cancer new therapeut rout castrat resist prostat cancer androgen depriv therapi adt import treatment inhibit androgen induc prostat cancer pca progress either prevent androgen biosynthesi eg abirateron antagon androgen receptor ar function eg bicalutamid enzalutamid darolutamid major limit current adt often remain effect limit durat patient common progress lethal incur form pca call castrat resist prostat cancer crpc ar continu orchestr pro oncogen signal inde increas number adt relat treatment emerg neuroendocrin like prostat cancer nepc lack ar thus insensit adt repres major therapeut challeng therefor urgent need better understand mechan ar action hormon depend diseas progress crpc enabl develop new approach prevent revers delay adt resist interest ar regul distinct transcript network hormon depend crpc appear relat aberr function key ar epigenet coregul enzym includ lysin demethylas lsdkdma review summar current best status anti androgen clinic trial potenti novel combin therapi explor recent advanc develop novel epigenet target therapi may relev prevent revers diseas progress patient advanc crpc | D011944;D064129 | T191;T116;T192 |
36,263,322 | associ follicl oocyt index clinic pregnanc ivf treatment retrospect studi fresh embryo transfer cycl aim studi investig whether follicl oocyt index foi number retriev oocytesantr follicl count associ clinic pregnanc fresh cleavag transfer | D004624;D005307 | T061;T010 |
36,263,321 | new insight import formul variabl parenter growth hormon prepar potenti effect inject site pain reduc inject site pain isp patient chronic condit growth hormon defici valuabl strategi improv patient complianc therapeut effici thus understand differ aspect pain induct follow subcutan inject biotherapeut identifi respons factor vital discuss effect formul viscos concentr osmol buffer agent ph temperatur well inject volum dose frequenc differ excipi isp follow subcutan inject commerci avail recombin human growth hormon product literatur review found limit avail data effect differ compon parenter rhgh product isp may due high cost associ conduct various clinic trial assess excipi formul determin complex interact differ compon impact isp recent conduct molecular dynam simul studi formul design recommend altern less expens approach hand observ inconsist avail data main due differ pain measur approach use studi moreov difficult translat data obtain anim studi human subject despit limit investig show compon parenter rhgh product signific contribut isp suggest investig requir develop long act buffer free preserv free formul besid various excipi current investig reduc isp use altern common buffer surfact preserv design futur rhgh formul | D019382 | T125;T121;T116 |
36,263,320 | downregulationof circ promot gestat diabet mellitus induc placent inflamm via nf b jnks pathway gestat diabet mellitus gdm one common diseas pregnanc patient gdm advers pregnanc outcom howev pathogenesi gdm complex well understood studi character express function circular rna circ gdm particular use qrt pcr verifi previous rna seq result show circ signific downregul placent villous tissu pregnant women gmd demonstr plasma exosom circ express second trimest effect predict gdm week furthermor htr svneo trophoblast downregul circ inhibit prolifer migrat induc apoptosi chang may induc chronic inflamm placenta effect circ downregul may mediat upregul nf b jnk pathway combin increas express level il il il tnf crp collect downregul circ may promot gdm induc chronic inflamm placenta via nf b jnk pathway furthermor find support circ potenti serv earli marker gdm | D016640;D010920;D000079962 | T018;T047;T114 |
36,263,318 | tcfl gene associ postprandi triglycerid dysmetabol novel mechan diabet risk among asian indian tcfl gene believ increas risk tdm effect insulin secret howev exact mechan enhanc risk clear known tcfl gene shown affect lipid metabol effect remain larg unexplor context diabet risk | D003924;D058118 | T123;T047;T116 |
36,263,317 | breastfeed behavior develop women gestat diabet mellitus qualit studi base health belief model china gestat diabet mellitus gdm condit women develop hyperglycemia pregnanc associ long term health burden mother offspr futur type diabet mellitus tdm although breastfeed expect mitig metabol sequela mother newborn preval breastfeed gdm mother sub optim worldwid | D016640;D003924 | T047 |
36,263,242 | efficaci intra articular inject platelet rich plasma combin mesenchym stem cell treatment knee osteoarthr systemat review meta analysi studi systemat evalu effect intra articular inject platelet rich plasma prp mesenchym stem cell msc knee osteoarthr koa | D020370;D053657;D059630 | T047;T025;T031 |
36,263,241 | current status phage therapi infecti diseas potenti applic beyond infecti diseas intestin microbiota play key role regul pathogenesi human diseas maintain health mani diseas main induc bacteria rise due emerg antibiot resist strain intestin microorgan includ organ bacteria virus fungi play import role maintain human health among microorgan phage main member intestin virom particular viral fraction compos essenti phage affect homeostasi exert select pressur bacteri communiti live intestin tract recent year widespread use even abus antibacteri drug drug resist bacteria found show trend high drug resist multidrug resist therefor also becom increas difficult treat serious bacteri infect phage natur antibacteri agent strong specif rapid prolifer come back field vision clinician scholar studi current state research intestin phage discuss explor impact phage therapi infecti diseas well potenti applic beyond infecti diseas | D000071059;D001424;D001435;D003141 | T061;T047;T005 |
36,263,240 | effect nonsurg spinal decompress intens pain herniat disc volum subacut lumbar herniat disc nonsurg spinal decompress therapi nsdt conserv treatment lumbosacr herniat intervertebr disc l hivd studi aim evalu clinic effect nsdt chang disc volum magnet reson imag mri subacut l hivd | D007405 | T047 |
36,263,239 | pit fissur sealant versus fluorid varnish prevent dental cari school children systemat review meta analysi children dental health becom main concern due increas cari preval amongst children pit fissur sealant pfs fluorid varnish fv effect measur prevent dental cari howev clinic efficaci intervent compar one anoth uncertain aim present systemat review meta analysi compar pit fissur sealant fluorid varnish cari prevent first perman molar among schoolchildren meta analysi involv random control trial compar effect pfs fv within month follow five databas search identifi studi publish arab english languag risk ratio rr confid interv cis calcul use random effect model total number studi includ overal children group three includ trial report cari increment first perman molar fpm month follow statist signific rr ci p regard dmfs increment analysi show statist differ fv pfs term lower dmfs increment md ci find meta analysi prove signific differ pfs fv cari prevent efficaci fpms year follow emphas use fv sinc afford easier appli | D010895;D003731 | T033;T122;T047 |
36,263,238 | rocuroinum dose adjust due lean bodi weight provid adequ intub condit prospect observ studi prospect observ studi patient age bmi expect general anesthesia less hour divid group accord bmi group bmi group bmi group bmi group random divid subgroup group lbw lbw lbw lbw given rocuronium intub dosag base lbw control group k k k given mgkg rocuronium accord total bodi weight data durat action rocuronium effect endotrach intub condit evalu | D000732;D003473 | T121;T109 |
36,263,237 | turkish valid reliabl studi challeng hindranc demand scale nurs profess studi aim adapt challeng hindranc demand scale nurs profession develop mahaverachartkul sooraksa regard nurs heavi workload stress well intens tire work hour perceiv mani stress situat work environ challeng hindranc turkish languag bring use nation literatur term method research design within scope quantit research model data collect nurs use studi research data analyz spss amo statist program valid scale use studi evalu exploratori factor analysi efa confirmatori factor analysi cfa accord efa find challeng demand scale kmo valu bartlett spheric test valu x p examin seen data suitabl analysi cfa find challeng demand scale examin seen fit indic accept level x p cmindf cfi tli rmsea srmr accord efa find hindranc demand scale kmo valu bartlett spheric test valu x p examin seen data suitabl analysi cfa find hindranc demand scale examin seen fit indic accept level x p cmindf cfi tli rmsea srmr conclus challeng hindranc demand scale nurs profession item four dimens develop measur stress hindranc challeng level nurs profession life turkey may use futur studi | D007802 | T171 |
36,263,236 | comparison perinat newborn audiometri result covid pregnant women studi perinat outcom covid audiometr effect matern immun system covid newborn clear studi aim investig relationship perinat outcom covid posit pregnant women audiolog outcom newborn | D000086382 | T047;T067 |
36,263,235 | epidemiolog trend attribut risk burden cervic cancer observ studi cervic cancer especi underdevelop area pose great threat human health view stratifi age social demograph index sdi base epidemiolog develop trend attribut risk cervic cancer countri region around world | D000071219;D002583 | T081;T191 |
36,263,234 | muscl activ pre treatment post treatment oral submuc fibrosi patient electromyographi studi oral submuc fibrosi osmf premalign condit insidi onset affect oral mucosa pharynx esophagus muscl mastic known affect result limit mouth open electromyographi emg sophist method measur evalu muscl activ previous emg primarili util medic scienc current use extens medic dentistri field | D009914 | T047 |
36,263,233 | factor affect physic activ peopl knee osteoarthr southern taiwan multipl logist regress analysi physic activ pa basic initi conserv manag peopl knee osteoarthr koa studi aim explor potenti indic pa level peopl koa | D020370 | T047 |
36,263,186 | tmp exert antitumor effect colorect cancer promot macrophag polar studi shown epigenet enzym histon deacetylas hdac close relat cancer sever hdac inhibitor exert antitumor effect studi suggest class iia hdac inhibitor relat immun function includ immun respons express chemokin complement pathway compon tmp select class iia hdac inhibitor report effect breast cancer howev role mechan tmp colorect cancer remain unknown studi found tmp signific reduc tumor burden two mous model coliti associ colorect cancer cac subcutan tumor mechanist tmp decreas proport total macrophag increas proport macrophag promot polar result increas releas inflammatori cytokin tmp direct effect prolifer colorect cancer cell antitumor effect colorect cancer disappear macrophag part deplet clodron liposom addit tmp enhanc efficaci pd blockad present studi reveal combin tmp pd blockad may provid therapeut strategi colorect cancer | D056572;D015179 | T121;T191;T126;T116 |
36,263,185 | identif gi novel molecular therapeut target cervic cancer studi express potenti function gi cervic cancer bioinformat analysi togeth result local patient tissu reveal gi express remark elev human cervic cancer tissu differ cervic cancer cell associ poor overal surviv poor diseas specif surviv patient gi deplet result profound anti cervic cancer activ primari immort cervic cancer cell gi shrna crisprca caus gi knockoutko larg hinder cell prolifer migrat provok apoptosi contrast ectop gi overexpress enhanc cervic cancer prolifer migrat akt mtor activ primari cervic cancer cell signific reduc gi silenc ko augment follow gi overexpress studi reveal transcript factor gata bind gi promot region signific enhanc cervic cancer tissu cell gi express decreas gata shrna upregul follow gata overexpress vivo growth cervic cancer xenograft robust suppress gi silenc ko gi deplet akt mtor inactiv detect gi silenc ko cervic cancer xenograft tissu togeth upregul gi valuabl oncotarget cervic cancer | D051057;D002583 | T191;T126;T116 |
36,263,184 | src defici prevent atherosclerosi develop decreas endotheli icam express attenu macrophag recruit steroid receptor coactiv src member p src famili factor interact multipl nuclear hormon receptor transcript factor regul express target gene although mani physiolog role src reveal role atherosclerosi clear studi found src apo mice reduc atherosclerot lesion necrot area aorta aortic root compar src apo mice western diet wd feed week rna seq western blot analys aorta reveal src requir maintain express icam requir macrophag recruit atherosclerosi develop sirna mediat knockdown src endotheli cell signific reduc wd induc atherosclerot plaqu format addit treatment apo mice src inhibitor bufalin prevent atherosclerot plaqu develop src defici reduc aortic macrophag recruit accord icam express mark decreas aorta src apo mice apo mice endotheli src knockdown mediat aav shsrc virus mechanist src coactiv nf b p increas icam transcript endotheli cell collect find demonstr inhibit src amelior atherosclerosi develop least part suppress endotheli activ decreas endotheli icam express via reduc nf b signal | D050197;D018799;D008264;D056921;D058226 | T129;T116;T025;T020;T047;T046;T031 |
36,263,183 | integr patholog analysi develop gal base immun surviv stratif predict outcom lung larg cell neuroendocrin carcinoma use immunotherapi studi aim integr cell spatial organ develop gal base immun surviv stratif lung larg cell neuroendocrin carcinoma lcnec investig potenti immunotherapi express gal twelv immun marker evalu case surgic lcnec sampl center use immunohistochemistri gal base immun surviv stratif risk score construct predict perform evalu thorough explor effect gal immun risk score lcnec immun pathway immun micro environ immunotherapi sensit differ cohort platform made valid patholog imag use histolog base digit stain hds lcnec sampl case posit gal express tumor cell gal tc increas gal tc predict wors overal surviv gal interact immun marker ad immun suppress immun toler lcnec immun protein marker base risk score consist gal cd cd pd l pd develop valid robust discrimin surviv high risk low risk lcnec patient high risk group character immun desert tumor less various cell low risk group featur immun inflam tumor like respond anti pd immunotherapi hds lcnec sampl cell valid high risk group tumor cell less stromal cell less lymphocyt higher tumor cell nucleic solid lower stromal cell nucleic solid integr patholog analysi confirm gal base immun surviv stratif distinct relat micro environ status involv immun suppress immun toler could act combinatori biomark predict outcom lcnec find may help effect stratifi lcnec patient sensit immunotherapi | D018287;D018278;D008175 | T191 |
36,263,182 | tradit chines medicin jingyingubiao formula therapi improv negat convers rate sar cov patient mild covid background tradit chines medicin tcm jingyingubiao formula jygb recommend expert consensus tradit chines medicin diagnosi treatment covid infect shanghai evalu safeti efficaci jygb treat mild covid patient method prospect doubl blind random control trial conduct clinicaltrialgov registr number chictr total patient random treatment group administr jygb n control group administr tcm placebo n day treatment primari outcom negat convers rate negat convers time sar cov rna secondari outcom includ hospit day symptom improv result total patient treatment control group complet studi cumul negat convers rate day day day day post random treatment group mark higher control group vs p vs p vs p vs p compar control group jygb treatment median negat convers time vs day p hospit day vs day p reduc symptom improv signific differ symptom disappear rate group addit sub group analysi show patient interv time day patient year clinic effect jygb remark increas cumul negat convers rate decreas negat convers time hospit day jygb well toler without sever side effect conclus jygb tcm prescript improv negat convers rate sar cov mild covid patient | D000086382 | T047;T067 |
36,263,181 | regul podocyt injuri circhipkfus complex diabet kidney diseas diabet kidney diseas dkd major microvascular complic diabet mellitus one lead caus end stage kidney diseas circular rnas circrna class endogen non code rnas play import role various diseas yet role dkd poor understood circrna hipk circhipk high conserv circrna close relat various cellular function includ cell prolifer apoptosi associ circhipk diabet complic well demonstr multipl previous studi howev role circhipk podocyt injuri dkd remain unclear herein discov circhipk express mark elev cultur podocyt high glucos hg condit glomeruli diabet mice close associ podocyt injuri dkd function lentivirus mediat knockdown circhipk dramat suppress hg induc podocyt apoptosi vitro therapeut silenc circhipk adeno associ virus mediat rna interfer amelior podocyt injuri albuminuria stz induc diabet mice mechanist circhipk facilit enrich fuse sarcoma fus ectodysplasin receptor edar promot result upregul edar express activ apoptot signal taken togeth result indic circhipkfusedar axi therapeut target podocyt injuri dkd progress | D050199;D003928;D003921 | T047;T050;T025 |
36,263,180 | hdac mediat smad silenc mefa critic fibroblast activ hypertroph scar format transform growth factor tgf signal play key role excess fibrosi class iia famili histon deacetylas hdac hdac show close relationship tgf signal fibrosi howev effect regulatori mechan hdac hypertroph scar hs format remain elus show hdac overexpress hs tissu deplet hdac attenu hs format vivo inhibit fibroblast activ vitro hdac knockdown kd signific downregul tgf induc smad phosphoryl increas smad express meanwhil smad kd rescu smad phosphoryl downregul scar hyperplasia inhibit mediat hdac defici luciferas report assay chip qpcr assay reveal hdac interact myocyt enhanc factor mefa suppress mefa bind smad promot region result smad promot activ repress hdac inhibitor lmk signific allevi hypertroph scar format studi provid clue develop hdac target strategi therapi prophylaxi fibrot diseas | D017439;D006655;D064326;D051906 | T026;T123;T116;T020;T126 |
36,263,179 | anp promot renal interstiti fibrosi upregul express fibrosi relat protein acid nuclear phosphoprotein famili member e anp report contribut earli mammalian develop cancer metastasi howev pathophysiolog role anp renal interstiti fibrosi rif poor understood demonstr anp high express region rif patient iga nephropathi unilater ureter obstruct uuo mous kidney boston univers mous proxim tubular bumpt cell treat tgf upregul posit correl total fibrot area kidney overexpress anp enhanc tgf induc product fibrosi relat protein fibronectin fn collagen type col bumpt cell wherea knockdown anp suppress deposit fibrosi relat protein uuo mice tgf stimul bumpt cell particular anp overexpress alon induc deposit fn col mous kidney bumpt cell without tgf stimul furthermor reveal overexpress anp induc express tgf p smad tgf inhibitor sb revers anp induc upregul fn col bumpt cell without tgf stimul collect data demonstr anp promot deposit fibrosi relat protein regul tgf smad pathway | D007674;D018832 | T123;T047;T116 |
36,263,178 | pyroptot cell death sar cov infect reveal role immunopathogenesi covid rapid dissemin sever acut respiratori syndrom coronavirus sar cov causat agent coronavirus diseas covid remain global public health emerg host immun respons sar cov play key role covid pathogenesi sar cov induc aberr excess immun respons lead cytokin storm syndrom autoimmun lymphopenia neutrophilia dysfunct monocyt macrophag pyroptosi proinflammatori form program cell death act host defens mechan infect pyroptosi depriv replic nich sar cov induc lysi infect cell expos virus extracellular immun attack notabl sar cov evolv sophist mechan hijack cell death mode surviv propag shed sar cov encod viral product act modul various key compon pyroptosi pathway includ inflammasom caspas gasdermin sar cov induc pyroptosi contriubt develop covid associ immunopatholog leakag intracellular content disrupt immun system homeostasi exacerb inflamm therefor pyroptosi emerg import mechan involv covid immunopathogenesi howev entangl link pyroptosi sar cov pathogenesi lack systemat clarif review briefli summar characterist sar cov covid relat immunopatholog moreov present overview interplay sar cov infect pyroptosi highlight recent research advanc understand mechan respons implic pyroptosi pathway covid pathogenesi provid inform inspir new direct investig clinic practic final discuss potenti valu pyroptosi therapeut target covid depth discuss under mechan covid pathogenesi conduc identif potenti therapeut target explor effect treatment measur aim conquer sar cov induc covid | D000086382 | T047;T067 |
36,263,177 | fto mediat autophagi promot progress clear cell renal cell carcinoma via regul sik mrna stabil progress clear cell renal cell carcinoma ccrcc remain major challeng clinic practic elucid molecular driver malign progress critic develop effect therapeut target recent studi demonstr n methyladenosin abund modif eukaryot mrna play key role tumorigenesi progress howev biolog role under mechan mediat autophagi cancer especi ccrcc remain poor elucid dot blot assay rna methyl assay kit immunofluoresc analysi use profil level tissu sampl correl autophag flux express pattern clinic signific fat mass obes associ protein fto determin bioinformat analysi real time pcr western blot immunohistochemistri rna seq merip seq merip qrt pcr rip qrt pcr transmiss electron microscopi immunofluoresc analysi luciferas report assay use investig under mechan fto autophagi axi role fto autophagi ccrcc progress evalu vitro vivo found modif suppress close relat autophag flux ccrcc elev fto inhibit rapamycin wherea silenc fto enhanc autophag flux impair ccrcc growth metastasi sik identifi function target mediat autophagi therebi prompt fto play conserv import role inhibit autophagi promot tumorigenesi igfbp depend mechan moreov small molecul inhibitor fb target fto inhibit tumor growth prolong surviv patient deriv xenograft pdx model mice suggest fto potenti effect therapeut target ccrcc find uncov crucial role ftoautophagysik axi modul progress ccrcc suggest fto may serv valuabl prognost biomark promis therapeut target ccrcc | D000071516;D002292;D007680 | T191;T126;T116 |
36,263,176 | biolog synthesi gold nanoparticl use cirsium japonicum var maackii extract studi anti cancer properti ag gastric cancer cell plant extract mediat synthesi metal nanoparticl nps eco friend cost effect biosynthesi method suitabl biolog applic chemic one prepar novel gold nps aunp cirsium japonicum mediat aunp cj aunp use biosynthet process involv cirsium japonicum herba cirsii cj ethanol extract physicochem properti cj aunp character use spectrometr microscop analys vitro stabil cj aunp studi month moreov select human gastric adenocarcinoma ag cell kill abil cj aunp verifi cancer normal cell vitro studi reveal cj aunp trigger oxid stress iron depend ferroptosi ag cell mechanist cj aunp induc mitochondri reactiv oxygen speci ros fe lipid peroxid accumul mitochondri damag destroy glutathion peroxidas gpx depend antioxid capac furthermor xenograft mous model implant ag cell treatment mgkg cj aunp day reduc tumor xenograft growth dose depend manner vivo without system toxic result demonstr cj aunp exert anticanc effect vitro vivo induc ferroptosi mediat cancer cell death studi base green synthes nanodrug induc ferroptosi provid new insight potenti develop cancer therapi | D031180;D053768;D013274 | T191;T073;T002 |
36,263,175 | humor immunogen sar cov vaccin liver transplant recipi systemat review meta analysi solid organ transplant recipi general show reduc immunogen various vaccin aim assess immunogen immun respons among orthotop liver transplant olt recipi sever acut respiratori syndrom coronavirus sar cov vaccin systemat search perform evalu immunogen advers event report sar cov vaccin pool analysi studi show humor immun respons rate confid interv ci sar cov vaccin among olt recipi immunogen among olt recipi signific lower compar overal popul healthi control odd ratio or howev signific higher patient receiv organ transplant especi kidney male sex old age chronic kidney diseas obes multipl high immunosuppress dose signific increas risk unrespons patient olt overal incid advers event vaccin ci similar control olt recipi overal humor immun respons rate sar cov vaccin lower healthi control favour compar solid organ transplant recipi | D016031;D000086382 | T061;T047;T067 |
36,263,174 | engin neoantigen vaccin improv cancer person immunotherapi immunotherapi treatment har immun system herald new era person medicin offer consider benefit cancer patient past year tumor neoantigen emerg rise star immunotherapi neoantigen tumor specif antigen aris somat mutat proceed present major histocompat complex cell surfac advanc sequenc technolog bioinformat engin recognit neoantigen acceler expect incorpor clinic routin current tumor vaccin neoantigen main encompass peptid dna rna dendrit cell extrem specif individu patient due high immunogen neoantigen tumor vaccin could activ expand antigen specif cd cd cell intensifi anti tumor immun herein introduc origin predict neoantigen compar advantag disadvantag multipl type neoantigen vaccin besid review immun current clinic research status neoantigen vaccin outlin strategi enhanc efficaci neoantigen vaccin final present challeng face applic neoantigen | D019496;D009369 | T129;T121;T191;T116 |
36,263,173 | chronic inflamm pathway nf b cooper epigenet reprogram drive malign progress glioblastoma without effect strategi target therapi glioblastoma still incur median surviv month chronic inflamm epigenet reprogram hallmark cancer howev mechan consequ cooper glioblastoma remain unknown discov chronic inflamm govern hkme reprogram glioblastoma canon nf b pathway target ezh crucial mediat chronic inflamm canon nf b signal specif direct express redistribut hkme hkme hkme hkme use rna seq screen focus gene encod methyltransferas demethylas histon identifi ezh key methyltransferas control inflamm trigger epigenet reprogram gliomagenesi mechanist nf b select drive express ezh activ transcript consequ result global chang hkme express distribut furthermor find co activ nf b ezh confer poorest clinic outcom risk glioblastoma accur molecular stratifi nf b ezh notabl nf b potenti cooper ezh one way import demonstr synergist effect cancer cell induc combinatori inhibit nf b ezh frequent activ glioblastoma summari uncov function cooper chronic inflamm epigenet reprogram glioblastoma combin target inhibitor guarante safeti avail furnish potent strategi effect treatment fatal diseas | D016328;D005909 | T129;T191;T116 |
36,263,172 | circular rna hsacirc promot tumor progress metastasi apatinib resist esophag squamous cell carcinoma mir crisp axi background circular rnas circrna attract grow interest research cancer regulatori role mechan circrna progress metastasi drug resist esophag squamous cell carcinoma escc need clarifi previous studi reveal crucial role apatinib escc therapi howev correl circrna apatinib resist remain unclear method pair tumor paracancer tissu escc patient use rna sequenc western blot analysi rna immunoprecipit rip dual luciferas report assay apoptosi anim assay conduct confirm role specif mechan hsacirc well effect apatinib sensit escc result result reveal hsacirc high express escc associ poor prognosi result indic hsacirc promot prolifer metastasi abil escc section mechan experi hsacirc regul crisp target microrna mir promot progress escc besid found silenc hsacirc improv apatinib sensit hsacirc result apatinib resist mir crisp axi conclus studi elucid function hsacirc role promot tumor progress metastasi apatinib resist escc mir crisp axi | D000077277;D004938;D035683 | T123;T191;T114 |
36,263,171 | function structur divers insect glutathion transferas xenobiot adapt superfamili multifunct enzym main associ xenobiot adapt glutathion transferas gsts facilit insect surviv chemic stress environ gsts confer xenobiot adapt direct metabol sequestr xenobiot andor indirect provid protect oxid stress induc xenobiot exposur articl comprehens overview current understand versatil function insect gsts detoxifi chemic compound present divers structur differ class insect gsts specif spatial local composit amino acid residu constitut activ site also summar recent avail whole genom sequenc numer insect speci accompani rna interfer x ray crystallographi enzym kinet site direct mutagenesi techniqu signific enhanc understand function structur divers insect gsts | D015262;D005982 | T123;T116;T126;T131 |
36,263,170 | small intestin specif knockout cidec improv obes hepat steatosi inhibit synthesi phosphatid acid small intestin main site exogen lipid digest absorpt import lipid metabol homeostasi cell death induc dna fragment factor like effector c cidec activ lipid metabol tissu intestin develop small intestin specif cidec si cidec knockout cblj mice creloxp recombin investig vivo effect intestin cidec lipid metabol eight week old si cidec mice fed high fat diet week lower bodi weight less bodi fat mass lower liver triglycerid tg wild type wt mice addit hepat steatosi fatti liver inflamm less sever knockout mice fed high fat diet hfd compar wild type mice fed hfd si cidec mice fed hfd diet lower serum tg higher fecal tg intestin lipas activ wild type mice mechanist studi show cidec acceler phosphatid acid synthesi interact acylglycerol phosphat acyltransferas promot tg accumul studi identifi new interact protein previous unreport cidec mechan reveal activ lipid metabol small intestin | D005234;D050356;D009765;D011506 | T123;T047;T116;T044 |
36,263,169 | cg regul enhanc pro migratori stem properti oval cell promot epitheli mesenchym like process previous data indic cg rapgef main isoform high express liver progenitor cell oval cell compar adult matur hepatocyt suggest may play import role oval cell biolog henc explor cg function regul oval cell properti perman gene silenc use shrnas found cg knock enhanc migratori invas abil oval cell promot partial epitheli mesenchym transit emt like mediat upregul mrna express emt induc transcript factor snail zeb zeb induc cg silenc oval cell emt associ higher express stem marker cd cd moreov cg regul increas oval cell clonogen capac enhanc cell scatter howev cg knock impair oval cell differenti hepatocyt lineag mechanist studi reveal hgfmet signal pro invas activ impair oval cell low level cg tgf signal increas altogeth data suggest cg might tight regul ensur liver repair chronic liver diseas non alcohol steatohepat henc reduc cg level could facilit oval cell expans prolifer peak enhanc migrat | D058750;D013234 | T081;T025;T043 |
36,263,168 | n methyladenosin soc modul macrophag inflammatori respons differ stiff environ macrophag exhibit divers function within various tissu inflammatori respons physic properti tissu also modul characterist macrophag howev under n methyladenosin associ molecular mechan remain unclear accord examin potenti role macrophag activ stiff sens intrigu found macrophag inflammatori respons global level stiff depend due mechan loosen chromatin epigenet modif hkme hdac addit target suppressor cytokin signal soc methyl stiff depend manner screen sequenc data found higher stiff hydrogel activ jak stat nfb signal suppress fto gene express next use crisprca system knockout fto gene macrophag demonstr fto affect stiff control macrophag inflammatori respons sustain negat feedback generat soc final determin reader ythdf bind soc mrna therebi maintain express soc result suggest fto soc ythdf regulatori axi vital stiff control macrophag inflammatori respons delet fto affect negat feedback control exert soc find increas understand regulatori mechan involv macrophag activ control inflamm | D050826;D008264 | T123;T116;T025 |
36,263,167 | neurotrophin promot hepatocellular carcinoma apoptosi jnk p mapk pathway although liver cancer malign tumor highest mortal across world pathogenesi therapeut target remain unclear apoptosi natur cell death mechan import target anticanc therapi discoveri effect apoptot regul lead identif novel therapeut target treat cancer neurotrophin ntf member nerv growth factor ngf famili involv progress various cancer includ medulloblastoma primit neuroectoderm brain tumor breast cancer ntf express human hepatocellular carcinoma hcc albeit specif effect action mechan elucid confirm ntf express signific low hcc refer gsea databas collect patient data center perform qrt pcr analysi found ntf express signific downregul patient hcc low ntf express associ shorter overal surviv os recurr free surviv rfs progress free surviv pfs diseas specif surviv dss vivo vitro experi reveal ntf consider inhibit progress hcc cell found ligand ntf regul c jun bind p neurotrophin receptor pntr activ jnk p mapk pathway induc apoptosi entinostat target hdachdac activ ntfpntr pathway result indic ntf tumor suppressor low express help predict poor clinic outcom hcc therefor ntf use potenti treatment molecul hcc | D017209;D006528;D008113;D020933 | T123;T191;T116;T043 |
36,263,166 | recent advanc organotyp tissu slice cultur anticanc drug develop organotyp tissu slice cultur establish anim patient tissu cultiv vitro ecosystem techniqu made countless contribut anticanc drug develop due vast number advantag preserv cell repertoir immun compon identif invas abil tumor toxic determin compound quick assess therapeut efficaci high predict perform drug respons import serv reliabl tool stratifi therapeut respond nonrespond select optim standard care treatment regimen person medicin expect becom potent platform even gold standard anticanc drug screen individu near futur | D017753;D000970 | T121;T070;T082;T109 |
36,263,165 | platelet deriv extracellular vesicl inhibit ferroptosi promot distant metastasi nasopharyng carcinoma upregul itgb nasopharyng carcinoma npc malign high metastat invas natur distant metastasi contribut substanti treatment failur mortal npc platelet versatil blood cell number platelet posit associ distant metastasi tumor cell howev role under mechan platelet respons metastasi npc cell remain unclear found distant metastasi npc patient posit correl express level integrin itgb platelet deriv extracellular vesicl ev npc patient p ev reveal ev transfer occur platelet npc cell mediat cell cell communic induc metastasi npc cell upregul itgb express mechanist p ev upregul itgb increas slca express enhanc protein stabil activ mapkerkatfnrf axi suppress ferroptosi therebi facilit metastasi npc cell npc xenograft mous model confirm p ev inhibit ferroptosi circul npc cell promot distant metastasi npc cell thus find elucid novel role platelet deriv ev npc metastasi improv understand platelet mediat tumor distant metastasi also import implic diagnosi treatment npc | D000079403;D000067128;D009303 | T026;T191;T043 |
36,263,164 | nobiletin suppress cholangiocarcinoma prolifer via inhibit gsk background cholangiocarcinoma cca type hepatobiliari cancer character uncontrol cell prolifer poor prognosi high mortal nobiletin nbt promis anti tumor compound deriv peel orang citrus plant citrus plant effect nbt cca remain unknown result data show nbt suppress cca cell prolifer vitro vivo coloni format edu assay indic nbt inhibit cell prolifer cell cycl analysi show nbt arrest cell cycl gg phase target predict show gsk direct target western blot immunofluoresc confirm nbt reduc phosphoryl gsk antiprolif effect nbt intercept gsk knockdown cca cell cellular thermal shift assay cetsa show nbt direct bound gsk final nbt show anti prolif effect tumor bear mice hepatotox conclus nbt could inhibit cca prolifer pharmacolog activ nbt cca attribut direct bind gsk suggest nbt might potenti natur medicin cca treatment | D018281;D001650 | T191 |
36,263,163 | mous model nonalcohol fatti liver diseas nafld pathomechan pharmacotherapi preval non alcohol fatti liver diseas nafld increas year year consequ nafld becom one preval liver diseas worldwid unfortun pharmacotherapi nafld approv unit state food drug administr despit promis pre clinic benefit situat highlight urgent need explor new therapeut target nafld discoveri effect therapeut drug mous one common use model studi human diseas develop novel pharmacotherapi due small size low cost eas genet engin differ mous model use simul various stage nafld induc dietari andor genet intervent review summar newli describ patho mechan nafld review preclin mous model nafld base method induct apprais use model anti nafld drug discoveri articl provid use resourc research select appropri model research base research question address | D065626 | T047 |
36,263,162 | hepat fgf emerg role inter organ crosstalk cancer fibroblast growth factor fgf one fgf member special endocrin properti last twenti year attract intens research develop physiolog function respond dietari manipul pharmacolog benefit improv macronutri metabol clinic valu biomark various human diseas general fgf produc major metabol organ subgroup liver show canon endocrin properti emphas special valu delin uniqu secretori function characterist hepat fgf growth literatur address extra hepat activ fgf mani strike find therefor publish yet fragment scatter controversi rais diverg find reason need systemat critic evalu current research aspect review focus current knowledg molecular biolog endocrin fgf especi present detail regul circul level fgf also emphas emerg role inter organ crosstalk cancer develop | D005346;D009369 | T123;T191;T116 |
36,263,161 | serolog respons human virom defin clinic outcom italian patient infect sar cov sever acut respiratori syndrom coronavirus sar cov respons pandem respiratori infecti diseas covid howev clinic manifest outcom differ signific among covid patient rang asymptomat extrem sever remain unclear drive dispar studi sequenti enrol hospit patient covid associ pneumonia brescia itali use virscan phage display method character circul antibodi bind viral peptid encod strain human virus sar cov infect associ mark increas immun antibodi repertoir mani known pathogen non pathogen human virus antivir antibodi respons link longitudin trajectori diseas sever confirm addit covid patient geograph region northern itali appli machin learn base strategi viral exposur signatur predict covid relat diseas sever link patient surviv develop valid result provid basi understand role memori b cell repertoir viral epitop covid relat symptom suggest uniqu anti viral antibodi repertoir signatur may use defin covid clinic sever | D000086402;D000086382 | T005;T067;T047 |
36,263,096 | vitro diagnost accuraci agreement dental microscop cone beam comput tomographi comparison microcomput tomographi detect second mesiobucc canal maxillari first molar percentag failur endodont treat maxillari molar relat high one main reason second mesiobucc canal mb miss techniqu propos detect mb studi aim assess diagnost accuraci agreement dental microscop cone beam comput tomographi cbct comparison microcomput tomographi micro ct detect mb maxillari first molar vitro | D008963;D054893 | T060;T023 |
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