PMID
int64 35.7M
36.4M
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36,339,984
|
develop integr solut patient neurostimul chronic pain time covid mobil applic support center chronic pain one preval patholog world treatment neurostimul carri extrem case requir larg invest resourc time covid pandem present comprehens solut monitor kind patient solut includ develop mobil applic support center remot monitor scrm
|
D063731;D000086382;D017216;D059350
|
T184;T067;T170;T047;T058
|
36,339,981
|
case report primari graft failur due revers lenticul descemet strip autom endotheli keratoplasti introduct import report detail clinic featur manag case descemet strip autom endotheli keratoplasti dsaek primari graft failur pgf due invert yet attach lenticul present case year old gentleman poor visual recoveri right eye undergo cataract surgeri year prior present visual acuiti count finger examin reveal endotheli decompens patient underw dsaek postop well attach lenticul howev cornea edemat three week surgeri optic coher tomographi oct reveal revers lenticul patient underw repeat dsaek unev postop cours visual acuiti month clear cornea well attach graft discuss pgf rare complic follow dsaek occur due poor endotheli function donor graft insert revers lenticul may get overlook caus pgf unless graft edg profil examin oct scan graft current case well attach despit invert posit suggest graft adher perhap function corneal endotheli pump isol may driven factor intraocular pressur conclus revers dsaek lenticul may normal adher host stroma must consid case pgf oct graft edg requir diagnosi perform repeat keratoplasti
|
D057111;D003316
|
T061;T047
|
36,339,973
|
modifi solid oil nanodispers contain vemurafenib lipid complex vitro vivo studi background vemurafenib vem licens drug treatment skin melanoma avail market oral tablet prescrib huge dose mgday one reason high dose vemurafenib low oral bioavail method vem lipid complex dlc predict base conquest mercuri program prepar use solvent evapor method use lipid phosphatidylethanolamin dlc subject character ft ir raman spectroscopi dsc tga p xrd fesem confirm complex dlc use prepar solid oil nanodispers dlc son subject vitro ex vivo vivo evalu comparison recent prepar convent son vem son dlc control result conquest mercuri predict avail intermolecular hydrogen bond vem phosphatidylethanolamin pe character test dlc ensur complex drug pe ex vivo studi show drug dlc son signific p higher skin permeat dlc control lower drug permeat convent son higher skin deposit p other half maxim inhibitori concentr ic prepar dlc son signific high p comparison convent son pure vem vivo permeat use confoc laser scan microscopi rat result indic convent son dlc son cross sc infiltr dermi epidermi dlc son higher luminancegray valu h dermi comparison convent son conclus novel lipid complex vem prepar use pe lipid enclos son show higher anticanc activ topic permeat well sustain deliveri good retent time dermi local drug suffici concentr elimin earli diagnos skin melanoma
|
D053758;D008545;D008628
|
T131;T196;T191;T073
|
36,339,963
|
dual ectop thyroid case report ectop thyroid gland uncommon disord thyroid tissu locat along line migrat dual ectop thyroid rare entiti part gland locat two differ locat
|
D013955;D050033
|
T019;T047
|
36,339,961
|
attitud practic barrier academ research among radiolog resid ethiopia cross section survey radiolog becom one sought resid program countri attract high qualifi candid countri object studi determin attitud practic barrier radiolog resid toward academ research
|
D011871;D007396
|
T065;T091;T097
|
36,339,960
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journey radiolog ethiopia practic radiolog began invent x ray spread differ part world document x ray introduc ethiopian medic practic howev radiolog profess place last four decad similar experi countri histori progress field radiolog ethiopian setup relat direct technolog advanc occur past decad radiographi main modal use first two decad earli year initi radiolog train radiograph ultrasound avail train servic subsequ year modern cross section imag equip introduc main accomplish involv privat institut play signific role far practic radiologist diagnostician recent also radiolog intervent also introduc commenc subspecialti train
|
D011871
|
T091
|
36,339,959
|
sonograph clinic featur typhliti pediatr cancer patient chemotheaphi tikur anbessa special hospit ethiopia typhliti neutropen enterocol necrot enteropathi right colon character clinic triad fever abdomin pain neutropenia imag find right side colon inflamm seen set sever neutropenia immun suppress patient undergo treatment malign organ transplant congenit acquir immunosuppress report clinic imag find typhliti pediatr cancer patient receiv chemotherapi largest tertiari center addi ababa ethiopia period month
|
D053706;D009369;D009503
|
T047;T191
|
36,339,958
|
level awar mammographi among breast cancer patient attend follow tertiari hospit addi ababa ethiopia breast cancer common cancer type common cancer relat caus death worldwid women studi aim assess awar mammographi among breast cancer patient attend follow tikur anbessa special hospit addi ababa ethiopia
|
D001943
|
T191
|
36,339,957
|
comput tomographi radiat exposur among urinari tract stone patient tikur anbessa special hospit retrospect studi nation multin survey indic larg variabl comput tomographi urinari tract stone dose wide use abdominopelv comput tomographi diagnosi rais issu radiat exposur henc studi conduct assess comput tomographi radiat exposur urinari tract stone patient compar result establish refer valu publish studi
|
D014545;D000069079
|
T037;T031
|
36,339,956
|
preval incident detect vascular compress abdomin comput tomographi abdominopelv vascular structur expos compress adjac organ might caus compress adjac hollow viscera condit asymptomat detect imag incident howev symptomat lead varieti uncommon syndrom abdomen pelvi aim studi assess preval incident abdominopelv vascular compress comput tomographi
|
D014057;D014652
|
T060;T047
|
36,339,955
|
preliminari review spine tumor radiolog intra oper histopatholog find addi ababa ethiopia spinal tumor constitut primari central nervous system tumor accur radiolog histopatholog diagnosi crucial manag prognosi aim studi describ imag pattern determin agreement imag pattern spinal tumor intra oper histopatholog find
|
D013125;D013120;D009442;D008577
|
T191
|
36,339,954
|
suggest local diagnost refer level possibl pediatr x ray optim addi ababa ethiopia earli childhood radiat exposur carri enhanc radiat risk two three time high adult object studi determin local diagnost refer level frequent pediatr x ray examin addi ababa ethiopia
|
D000082162;D010372
|
T081;T091
|
36,339,953
|
preliminari understand abdomin aortic common iliac arteri diamet abdomin ct ethiopian adult facil base cross section studi mean aortic common iliac arteri diamet best indic diagnosi aortic iliac ectasia aneurysm well appropri select angiograph cathet size graft endovascular procedur current lack evid regard normal abdomin aortic common iliac arteri diamet ethiopian adult studi aim assess mean diamet associ factor abdomin aorta common iliac arteri abdomin ct scan ethiopian adult visit tikur anbessa special hospit addi ababa ethiopia
|
D001012;D007083
|
T023
|
36,339,952
|
pattern mri find patient chronic headach retrospect studi privat diagnost center addi ababa ethiopia headach one common complaint lead patient seek medic advic howev patient recurr headach secondari caus like intracrani mass appropri util neuroimag import rule secondari caus headach resourc limit region object studi describ pattern mri find evalu patient chronic headach determin clinic variabl help identifi patient intracrani lesion
|
D008279;D020773
|
T060;T047;T170;T059
|
36,339,942
|
regul cd cxcr follicular helper tfh cell cd cd hi cd hi regulatori b breg cell gastric cancer follicular helper tfh cell regulatori b breg cell report play essenti role humor immun especi inflamm autoimmun diseas cancer henc sought investig involv cxcr cd tfh cell cd cd hi cd hi breg cell gastric cancer
|
D060151;D013274
|
T191;T025
|
36,339,941
|
differenti express bioinformat analysi plasma deriv exosom circrna type diabet mellitus exosom circular rna circrna report particip pathogenesi type diabet mellitus tdm howev exact role exosom circrna tdm larg unknown identifi exosom circrna express profil plasma tdm patient explor potenti function use bioinformat analysi materi method exosom extract size exclus chromatographi method plasma tdm patient age sex match control subject illumina novaseq platform use detect exosom circrna express profil multipl bioinformat analysi appli investig potenti biolog function exosom circrna
|
D003922;D035683
|
T123;T047;T114
|
36,339,940
|
betain inhibit nlrp inflammasom hyperactiv regul microgli mm phenotyp differenti therebi attenu lipopolysaccharid induc depress like behavior depress one import mental ill close relat inflamm betain natur product anti inflammatori antioxid activ howev mechan betain amelior depress like behavior induc lipopolysaccharid lps poor understood purpos studi investig neuroprotect effect betain lps induc depress like behavior mice mechan action icr mice random divid four group control group lps model group mgkg posit drug group mido mgkg betain group drink water betain group administ day nd day except blank group lps mgkg intraperiton inject establish lipopolysaccharid induc mice depress like model twenti four hour lps inject tail suspens test tst open field test oft sucros prefer test spt perform evalu effect betain lps induc depress behavior mice behavior studi mous brain hippocampus serum taken detect express cytokin inflammatori mediat detect elisa stain immunofluoresc immunohistochemistri western blot western blot use detect protein express level nucleotid bind oligomer domain like receptor protein nlrp caspas asc protein express level microgli polar marker cox induc nitric oxid synthas ino cd result show betain signific amelior depress like behavior lps induc mice signific attenu product proinflammatori cytokin increas releas anti inflammatori cytokin betain decreas express nlrp inflammasom decreas express polar marker tumor necrosi factor alpha tnf interleukin il cox ino promot express polar marker cd studi suggest betain may promot transit microglia phenotyp inhibit nlrp inflammasom activ therebi attenu lipopolysaccharid induc depress like behavior
|
D058847;D008070
|
T123;T116;T109
|
36,339,939
|
effect lymphocyt subset bone densiti senil osteoporosi retrospect studi sever studi shown lymphocyt subset mediat occurr osteoporosi op howev predict abil lymphocyt subset senil op elucid
|
D015519;D010024
|
T201;T081;T047
|
36,339,685
|
logist entropi trabecular bone score sle patient new type visual medic imag refer interv diagnosi treatment process diseas undoubt import clear easi interpret imag refer interv deriv medic devic statist method respect great import doctor diagnosi treatment process articl system lupus erythematosus diseas transform refer interv fuzzi set calcul entropi valu find uncertainti contain refer interv system lupus erythematosus diseas doctor keep view patient treatment use entropi valu final better observ patient help entropi function new type medic imag given trabecular bone diseas use wolfram mathematica note type medic imag bone miner densiti medicin
|
D010024;D008180
|
T047
|
36,339,684
|
unsupervis deep learn base model use multiom data predict prognosi patient stomach adenocarcinoma patient total stomach adenocarcinoma cancer genom atlas tcga cohort includ autoencod construct integr rna sequenc mirna sequenc methyl data featur bottleneck layer use perform k mean cluster algorithm obtain differ subgroup evalu prognosi relat risk stomach adenocarcinoma model robust verifi use fold cross valid cv surviv analyz kaplan meier method univari multivari cox regress use estim hazard risk model valid three independ cohort differ endpoint
|
D000077321;D000230;D013274
|
T191;T066
|
36,339,683
|
analysi prognost factor construct prognost model invas micropapillari carcinoma breast compar analyz clinic characterist invas micropapillari carcinoma impc breast impc b invas ductal carcinoma idc breast idc b establish prognost model impc b
|
D018270;D002291;D001943
|
T191
|
36,339,682
|
relat gene contribut poor prognosi hepatocellular carcinoma hepatocellular carcinoma hcc one common lethal digest system cancer worldwid n methyladenosin modif play essenti role divers critic biolog process may particip develop progress hcc
|
D006528;D008113
|
T191
|
36,339,661
|
sar cov infect among student univers porto cross section studi object aim quantifi sar cov specif antibodi seropreval among univers student porto method rapid point care test sar cov specif immunoglobulin ig igg antibodi perform questionnair appli voluntari student septemb decemb comput appar igm igg igm igg preval true preval credibl interv ci use bayesian infer result found appar preval igm igg true preval ci preval signific higher among male vs intern student vs local vs nation displac increas age known risk contact experienc quarantin symptom previous negat molecular test higher seropreval student report molecular diagnosi reactiv igm igg conclus base immunolog evid infect fold report molecular diagnosi higher seropreval among male older intern student emphas import identifi particular group
|
D000086382
|
T047;T067
|
36,339,660
|
companion pandem covid use inform practic access public healthcar servic european union object object paper evalu use inform payment person connect gain preferenti access public health servic covid pandem propos effect polici measur tackl phenomenon method use data patient european union six differ scenario analyz relat make inform payment andor reli person connect access public healthcar servic evalu propens engag inform practic healthcar probit regress sampl select predict probabl use robust check also perform test reliabl find result scenario statist signific associ reveal propens make inform payment andor reli person connect asymmetri formal rule patient person norm trust public author conclus tackl inform practic healthcar polici measur requir reduc asymmetri formal rule person norm rais trust public author
|
D005382;D000086382
|
T081;T047;T052;T067
|
36,339,659
|
effect covid relat intervent incid infecti eye diseas analysi nationwid infecti diseas incid monitor data object social distanc confirm reduc incid covid also incid diseas therefor studi aim investig effect social distanc polici incid infecti eye diseas monitor nationwid incid data age group method studi analys impact covid polici iedsc time period divid two intervent first intervent first covid patient report korea januari second intervent relax social distanc polici may segment regress analysi interrupt time seri use assess covid polici iedsc result first incid covid patient iedsc decreas signific age group relax social distanc polici increas iedsc signific most group conclus post covid era hope nation level intervent reduc air pollut employ precautionari measur signific reduc financi burden develop infecti ophthalm diseas
|
D000086382;D003141;D005128
|
T047;T067
|
36,339,450
|
leverag strength mice human stem cell organoid model pancrea develop diabet diabet epidem increas incid across world individu afflict diseas type diabet mani suffer type autoimmun disord type diabet complex genet underpin complic epigenet environment factor less preval often diagnos subset diabet case character singl genet mutat includ matur onset diabet young modi neonat diabet mellitus ndm mode action cours treatment form diabet distinct diseas eventu result dysfunct andor death pancreat cell bodi sourc insulin loss cell function blood glucos homeostasi disrupt life threaten complic aris review focus model system provid substanti insight understand cell biolog inform understand form diabet strength weak anim hpsc deriv like cell organoid model consid along discuss gata critic transcript factor frequent implic pancreat dysfunct development origin experiment studi gata highlight advantag disadvantag model system use inform understand cell specif function health diseas
|
D003924;D050417
|
T047;T025
|
36,339,449
|
combin bioinformat network pharmacolog artifici intellig predict mechan celastrol treatment type diabet type diabet td common chronic diseas mani serious complic celastrol prevent treat type diabet revers insulin resist number way howev specif mechan celastrol prevent treat td well understood aim studi explor key gene target potenti signal pathway mechan celastrol treatment td
|
D019295;D003924
|
T047;T091
|
36,339,448
|
critic role gut microbiota obes obes global epidem character energi disequilibrium metabol disord fat mass develop chronic low grade inflamm signific affect health state individu age strain socioeconom system preval obes rise alarm rate etiolog involv complic interplay diet genet environment factor gut microbiota import constitu environment factor confirm correl onset progress obes howev specif relationship obes gut microbiota associ mechan fulli elucid review summar microbi divers signific decreas firmicutesbacteroidet ratio signific increas obes alter gut microbiota associ metabolit contribut progress diseas disrupt energi homeostasi promot lipid synthesi storag modul central appetit feed behavior well trigger chronic inflamm intent manipul gut microbiota held promis novel therapi obes includ probiot prebiot fecal microbiota transplant
|
D000069196
|
T007;T001
|
36,339,447
|
leptin receptor antagonist attenu experiment autoimmun thyroid mice regul tregth cell differenti leptin found involv develop progress mani autoimmun diseas organ specif autoimmun diseas pathogenesi hashimoto thyroid fulli elucid report serum leptin level increas hashimoto thyroid studi shown differ replic mous model experiment autoimmun thyroid eat high iodin diet found inject leptin receptor antagonist allo aca reduc thyroid follicl destruct inflammatori cell infiltr eat mice thyroxin thyroid autoimmun antibodi level investig reveal allo aca promot differenti treg cell inhibit differenti th cell believ allo aca alter differenti tregth cell inhibit leptin signal pathway therebi allevi thyroid injuri eat mice interf leptin signal pathway may novel new approach treat treat amelior hashimoto thyroid
|
D013967;D050031;D001327
|
T047
|
36,339,446
|
role mesenchym stem cell deriv exosom diabet mellitus relat complic diabet mellitus type metabol diseas character hyperglycemia primarili caus defect insulin secret insulin action long term chronic hyperglycemia lead diabet relat complic caus damag dysfunct failur differ organ howev tradit insulin oral drug therapi treat symptom delay progress failur pancreat beta cell prevent emerg diabet complic mesenchym stem cell receiv extens attent due strong immunoregulatori function regener effect mesenchym stem cell deriv exosom msc exo propos novel treatment diabet patient demonstr superior effici mesenchym stem cell review summar therapeut effect mechan challeng futur prospect msc exo treat diabet mellitus relat complic review support potenti use msc exo futur regen medicin overcom current difficulti clinic treatment particular treat diabet
|
D055354;D059630;D006943;D003920;D061385
|
T026;T121;T025;T033;T047
|
36,339,444
|
free bioavail hydroxyvitamin level associ diabet ketoacidosi children type diabet diagnosi consid role hydroxyvitamin ohd glucos homeostasi immun modul vitamin defici may relat develop type diabet tdm diabet ketoacidosi dka evalu total free bioavail ohd level vitamin bind protein vdbp level genotyp tdm patient control
|
D016883;D003922
|
T047
|
36,339,443
|
tripl drug therapi gaba sitagliptin omeprazol prevent type diabet onset promot revers non obes diabet mice previous studi report dual drug combin consist aminobutyr acid gaba togeth dipeptidyl peptidas inhibitor dpp also dpp proton pump inhibitor ppi could improv pancreat cell function amelior diabet diabet mice studi sought determin tripl drug combin gaba dpp ppi might superior therapeut effect compar doubl drug therapi prevent revers diabet non obes diabet nod mous model human type diabet td diabet prevent arm studi tripl drug combin gaba dpp ppi exhibit superior therapeut effect prevent onset diabet compar doubl drug combin placebo also tripl drug combin signific increas circul c peptid serum insulin level mice diabet revers arm studi tripl drug combin superior doubl drug combin reduc hyperglycemia mice addit tripl drug combin effect increas circul level c peptid serum insulin therebi signific reduc exogen insulin need combin gaba dpp ppi appear promis easili scalabl therapi treatment prevent td
|
D003921;D003922;D054873
|
T121;T047;T050
|
36,339,442
|
androgen improv ovarian follicl function impair glucocorticoid androgen igf fsh synergist effect high concentr glucocorticoid caus chronic stress known affect ovarian function caus diminish ovarian reserv androgen essenti earli stage ovarian follicl develop effect mechan androgen follicl develop chronic stress remain unclear studi aim investig effect high concentr glucocorticoid function vitro cultur ovarian cell mous earli stage ovarian follicl valid hypothesi androgen insulin like growth factor igf follicl stimul hormon fsh synergist signal help amelior damag caus high concentr glucocorticoid kgn cell human granulosa cell line mous primari cell treat differ concentr glucocorticoid cell prolifer apoptosi sex hormon secret detect effect glucocorticoid androgen igf receptor igfr fsh receptor fshr express kgn cell detect western blot steroidogen synthas express androgen androgen igf fsh combin treatment examin qpcr manipul use low high concentr glucocorticoid mechan androgen regul igfr fshr explor small interf rna sirna chromatin immunoprecipit chip qpcr damag glucocorticoid treatment effect androgen valid mous ovarian follicl cultur vitro result demonstr prolong treatment high dose glucocorticoid reduc cell viabil granulosa cell inhibit sex hormon secret impair sensit igf fsh signal affect igfr fshr function androgen appropri dose rang improv earli stage follicl develop hormon secret high dose glucocorticoid treatment relat increas transcript igfr fshr work show excess glucocorticoid impair ovarian function valid balanc concentr androgen synerg igf fsh improv function earli stage ovarian follicl condit chronic stress
|
D000728;D005938
|
T125;T121;T039;T109
|
36,339,441
|
respons target radionuclid therapi mibg lu lu dota tate accord adren vs extra adren primari locat metastat paraganglioma pheochromocytoma systemat review target radionuclid therapi trt mibg lu lu dota tate altern treatment classic scheme slow progress metastaticinoper paraganglioma pgl pheochromocytoma pheo consensus treatment administ andor best sequenc patient candid therapi clarifi question systemat review assess prognost valu mibg lu lu dota tate prrt lu treatment term progress free surviv pfs global consid primari locat
|
D010673;D010235;D000310
|
T191
|
36,339,440
|
associ hyperuricemia metabol syndrom cross section studi tibetan adult tibetan plateau studi aim assess relationship serum uric acid metabol syndrom compon tibetan adult tibetan plateau
|
D033461;D024821
|
T047
|
36,339,439
|
optic coher tomographi retina combin color doppler ultrasound tibial nerv diagnosi diabet peripher neuropathi investig valu retin nerv fiber layer rnfl thick optic disc cross section area csa lower limb nerv diagnosi diabet peripher neuropathi dpn separ combin
|
D003929;D003924
|
T047
|
36,339,438
|
critic analysi current tnm classif differenti thyroid carcinoma young patient time chang current tnm classif simpli classifi differenti thyroid carcinoma dtc patient younger year stage stage ii base presenc absenc distant metastas question studi reexamin impact status n status prognosi develop new predict model improv predict cancer specif surviv css young patient
|
D013964;D018263
|
T191
|
36,339,437
|
triglycerid glucos index predict major advers cardiovascular event patient type diabet mellitus coronari arteri bypass surgeri retrospect cohort studi insulin resist ir signific risk factor cardiometabol diseas defin featur type diabet mellitus tdm studi aim examin potenti valu triglycerid glucos tyg index predictor prognosi coronari heart diseas chd patient tdm coronari arteri bypass graft cabg surgeri facilit identif high risk major advers cardiovascular event mace closer monitor possibl earli intervent
|
D003924;D002318
|
T047
|
36,339,436
|
establish valid clinic model predict diabet ketosi patient type diabet mellitus diabet ketosi dk one lead caus hospit among patient diabet failur recogn dk symptom may lead complic diabet ketoacidosi sever neurolog morbid death
|
D016883;D003924
|
T047
|
36,339,435
|
tear function patient diabet mellitus systemat review meta analysi examin tear function patient diabet mellitus dm
|
D013666;D003924
|
T047;T031
|
36,339,434
|
perchlor nitrat thiocyan environment relev nis inhibitor pollut impact thyroid function human health thyroid disruptor found food atmospher soil water contamin interfer thyroid function impair thyroid hormon synthesi plasma transport peripher metabol transport target cell thyroid hormon action well known iodid uptak mediat sodium iodid symport nis first limit step involv thyroid hormon product therefor describ sever thyroid disruptor interfer thyroid function regul nis express andor activ perchlor nitrat thiocyan competit inhibit nis mediat iodid uptak contamin main found food water smoke cigarett although impact human exposur anion high controversi studi indic deleteri effect thyroid function especi individu live iodin defici area consid critic role thyroid function product thyroid hormon growth metabol develop review summar impact exposur nis inhibitor thyroid function consequ human health
|
D010472;D004785
|
T131;T197
|
36,339,433
|
implic metabol health status obes risk kidney cancer nationwid popul base cohort studi studi evalu associ metabol health status incid kidney cancer among obes particip
|
D000067329;D007680
|
T184;T191
|
36,339,432
|
hdac emerg therapeut target metabol disord histon deacetylas hdac member class iv hdac latest member identifi high express brain heart kidney organ locat mitochondria cytoplasm nuclei depend tissu cell type although studi hdac total knockout mice suggest dispens featur tissu develop life particip divers pathophysiolog process dna replic tumor growth immun regul oxid stress injuri neurolog function cocain recent studi shown hdac also critic involv pathogenesi metabol diseas includ obes diabet complic diabet review summar recent progress role mechan hdac regul metabol disord focus regul adipogenesi lipid metabol metabol inflamm glucos toler immun respons energi consumpt also discuss properti select hdac inhibitor applic varieti vitro vivo model metabol disord given pharmacolog genet inhibit hdac exert benefici effect various metabol disord hdac may potenti therapeut target treat chronic metabol diseas
|
D006655;D008659
|
T026;T047;T126;T116
|
36,339,431
|
prevent type diabet late stage pre diabet nod mice insulin central role alum adjuv restor immun toler diseas relev antigen appeal approach prevent arrest organ specif autoimmun diseas like type diabet td numer studi identifi insulin key antigen interest use strategi date success intervent human inconsist efficaci antigen specif immunotherapi may enhanc optimis dose time rout administr perhap inclus adjuv like alum aim studi evalu effect insulin peptid vaccin formul alum prevent td develop femal non obes diabet nod mice administ late stage pre diabet
|
D003922;D011236
|
T047
|
36,339,430
|
combin signatur glycolysi immun landscap predict prognosi therapeut respons prostat cancer prostat cancer pca common malign pose major threat health men prostat specif antigen psa deriv fda approv detect assay insuffici serv optim marker patient prognosi clinic decis make wide acknowledg aberr glycolyt metabol pca relat tumor progress acidifi tumor microenviron tme consid non neglig impact glycolysi immun function pca develop combin classifi prostat cancer glycolysi score contain gene tme score includ three immun cell creat use univari multivari cox proport hazard model log rank test least absolut shrinkag select oper lasso regress analysi bootstrap approach combin glycolysi immunolog landscap glycolysi tme classifi construct observ classifi accur predict prognosi patient current biomark notabl signific differ metabol activ signal pathway mutat landscap immunotherapeut respons drug sensit among glycolysishightmelow mix group glycolysislowtmehigh identifi classifi overal due signific prognost valu potenti therapeut guidanc glycolysi tme classifi anticip classifi clinic benefici manag patient pca
|
D011471
|
T191
|
36,339,429
|
systemat review meta analysi gut microbiota diabet kidney diseas comparison diabet mellitus non diabet kidney diseas healthi individu gut microbiota report play import role diabet kidney diseas dkd howev alter gut bacteria determin
|
D000069196;D003928;D003920
|
T047;T007;T001
|
36,339,428
|
precoci puberti microbiota role sex hormon gut microbiom axi puberti critic phase life associ physiolog chang relat sexual matur repres complex process regul multipl endocrin genet control puberti driven hormon impact gut microbiom gm gm differ sex emerg puberti onset confirm relationship microbiota sex hormon narrat review present overview precoci pubert develop chang gm precoci puberti pp order consid role sex hormon gut microbiom axi perspect pediatr endocrinolog bidirect interact gm sex hormon propos differ studi although evid interact microbiota sex hormon remain limit pediatr patient evid gm alter may occur girl central precoci puberti cpp repres interest find predict prevent pp deepen understand connect sex hormon role microbiota chang lead implement microbiota target therapi pubert disord offer pediatr endocrinolog perspect
|
D011629;D000069196;D064307
|
T032;T007;T028;T047;T001
|
36,339,427
|
causal relationship osteoporosi osteoarthr two sampl mendelian random studi present clinic studi confirm osteoporosi op invers relationship osteoarthr oa proven point view genet studi hope clarifi potenti effect op oa level gene predict two sampl mendelian random mr analysi
|
D015207;D020370;D010024
|
T047
|
36,339,426
|
singl cell rna seq analysi cell cluster deconvolut human preovulatori follicular fluid cell provid insight pathophysiolog ovarian hyporespons reduct respons gonadotropin hyporespons may lead failur vitro fertil ivf due low number retriev oocyt ovarian sensit index osi use reflect ovarian respons gonadotropin stimul ivf although introduc clinic practic alreadi year ago use predict clinic outcom requir research nevertheless pathophysiolog mechan ovarian hyporespons along advanc matern age younger women fulli elucid follicl consist multipl cell type respons repertoir biolog process includ respond pituitari gonadotropin necessari follicl growth oocyt matur well ovul encourag evid suggest hyporespons could influenc mani contribut factor therefor investig variabl ovarian follicular cell type gene express hyporespond high inform increas prognosi ivf live birth due advanc singl cell analysi technolog role somat cell popul develop infertil ovarian etiolog clarifi somat cell collect fluid preovulatori ovarian follicl patient undergo ivf rna seq perform studi associ osi gene express identifi molecular pathway differenti regul hypo normorespond patient group fdr lt extracellular matrix organ post translat protein phosphoryl regul insulin like growth factor igf transport uptak igf bind protein regul age independ generat singl cell rna seq data match follicl reveal distinct cell cluster use cell cluster specif deconvolut bulk rna seq data ivf patient integr dataset novel approach discov abund three cell cluster signific vari hypo normorespond group suggest role contribut deviat normal ovarian respons gonadotropin stimul work uncov new inform regard differ follicular gene express hypo normorespond addit current studi fill gap understand inter patient variabl cell type human preovulatori follicl reveal singl cell analysi follicular fluid cell
|
D015571;D009865
|
T025;T031
|
36,339,425
|
bibliometr studi global trend diabet gut flora research diabet mellitus serious metabol diseas caus serious econom burden worldwid gut flora major compon diabet research aim studi understand trend major compon research relat diabet gut flora last year
|
D000069196;D003920
|
T047;T007;T001
|
36,339,424
|
comparison insulin requir across gestat women hyperglycemia pregnanc prospect cohort studi aim studi explor daili insulin dose percentag chang preprandi basal insulin dosag women differ type hyperglycemia pregnanc hip whole gestat postpartum period
|
D003922;D016640;D003924;D011254;D006943
|
T033;T047
|
36,339,423
|
lifestyl chang risk tuberculosi patient type diabet mellitus nationwid cohort studi investig impact lifestyl chang name smoke alcohol intak exercis develop tuberculosi tb patient type diabet mellitus tdm retrospect popul base cohort studi use data korean nation health insur system databas examin subject diagnos tdm without previous histori tb underw two serial health examin studi particip classifi four group base chang pattern smoke alcohol intak exercis time second examin outcom studi newli diagnos tb patient tdm among includ subject tb newli diagnos subject consist smoker hr ci new smoker hr ci higher tb risk smoke quitter hr ci never smoker consist heavi drinker hr ci heavi drink quitter hr ci higher tb risk new heavi drinker never drinker respect exercis persist non exercis hr ci exercis quitter hr ci higher tb risk new exercis subgroup analysi signific interact observ lifestyl chang age found lifestyl chang associ develop tb patient tdm result suggest lifestyl manag could valuabl strategi control tb korea
|
D003924;D014376
|
T047
|
36,339,422
|
asian case combin hydroxylas lyas defici due homozyg prq mutat case report review literatur combin hydroxylas lyas defici ohd rare form congenit adren hyperplasia cah caus mutat cypa gene almost differ mutat cypa gene report includ prq mutat case prq mutat describ asian popul
|
D000312;D008659
|
T047
|
36,339,421
|
ferroptosi potenti target intervent intervertebr disc degener ferroptosi iron depend form program cell death mark phospholipid peroxid regul complex cellular metabol pathway includ lipid metabol iron balanc redox homeostasi mitochondri activ initi research regard mechan ferroptosi main focus solut carrier famili member glutathioneglutathion peroxidas gpx signal pathway recent novel mechan ferroptosi independ gpx discov numer patholog associ extens lipid peroxid drug resist cancer ischem organ injuri neurodegen diseas driven ferroptosi ferroptosi new therapeut target intervent ivdd role ferroptosi modul intervertebr disc degener ivdd signific topic interest novel research topic research mechan ivdd ferroptosi ongo herein aim review discuss literatur explor mechan ferroptosi relationship ivdd ferroptosi regulatori network cell nucleus pulposus annulus fibrosus cartilag endplat provid refer futur basic research clinic translat ivdd treatment
|
D000079403;D055959
|
T047;T190;T043
|
36,339,420
|
dose depend stimul human follicular steroidogenesi novel rhcg ovarian stimul fix rfsh dose choriogonadotropin cg beta fe novel recombin human h cg produc human cell line longer half life higher potenc cg alfa produc chines hamster ovari cell line hcg augment steroid product extent cg beta treatment ovarian stimul os increas steroidogenesi unknown
|
D011374;D027682
|
T123;T121;T116;T109;T125
|
36,339,419
|
clinic characterist influenc rs patient camurati engelmann diseas camurati engelmann diseas ced scleros bone dysplasia caus transform growth factor tgfb gene variant
|
D003966
|
T047
|
36,339,418
|
integr genom analysi transcript express abcc kcnj focal form congenit hyperinsulin focal form chi caus autosom recess pathogen variant affect patern homologu gene abcc kcnj second somat event specif occur affect islet langerhan approach studi integr genet chang occur pancreat focal lesion chi genom transcript level
|
D024661;D044903
|
T123;T047;T116
|
36,339,416
|
yin huo tang tradit chines herbal formula reliv ovariectomi empti bottl stimul induc menopaus like symptom mice yin huo tang yht tradit chines herbal formula effect use clinic treatment menopaus like symptom china studi aim investig efficaci menopaus like symptom mice use behavior test histopatholog assess determin possibl mechan action base network pharmacolog
|
D008593;D004967
|
T121;T109;T033;T125;T039
|
36,339,415
|
vacuol embryo day vitro develop associ stimul protocol embryo develop chromosom status pregnanc neonat outcom vacuol embryo day associ parent relat factor stimul protocol embryo develop embryo ploidi pregnanc neonat outcom
|
D046149;D001755
|
T018;T059
|
36,339,414
|
genet risk score improv predict treatment gestat diabet mellitus diabet mellitus chronic diseas caus interact genet environ lead chronic damag mani organ system genom wide associ studi identifi accumul singl nucleotid polymorph relat type diabet mellitus gestat diabet mellitus genet risk score grs util evalu incid risk improv predict optim treatment articl review research progress use grs diabet mellitus recent year discuss futur prospect
|
D016640;D003924
|
T047
|
36,339,411
|
hypothesi metformin potenti reproduct toxic metformin first line oral treatment type diabet mellitus prescrib million peopl worldwid metformin effect glucos lower drug well document precis mechan action unknown recent find associ patern metformin treatment increas number genit birth defect son tendenc toward skew secondari sex ratio less male offspr prompt us focus evid reproduct side effect drug metformin human document reduc circul level testosteron men women experiment anim model metformin exposur utero induc sex specif reproduct chang adult rat male offspr reduc fertil manifest decreas litter size metformin exposur fish induc intersex document testicular tissu metformin excret unchang urin fece present wastewat even effluent wastewat treatment plant spread river lake drink water document present numer freshwat sampl throughout world even drink water present hypothesi metformin need consid potenti reproduct toxic human probabl also wildlif urgent need studi explor associ metformin exposur reproduct outcom human experiment anim aquat wildlif
|
D008687;D003924;D060766
|
T121;T047;T167;T109
|
36,339,410
|
associ glpr variant rs rs obes metabol paramet polish cohort obes complex diseas associ excess fat accumul numer metabol complic far mani factor lead develop disord identifi includ genet suscept various studi link glpr variant anthropometr metabol paramet suggest role variat gene metabol health
|
D000067757;D024821
|
T047;T192
|
36,339,409
|
rna seq base endometri recept test rsert compar pinopod better diagnost tool endometri recept patient recurr implant failur chines popul displac window implant woi one endometri origin account implant failur especi patient recurr implant failur rif yet standard diagnost tool recogn studi consist two part aim compar concord efficaci diagnost tool newli develop rna seq base endometri recept test rsert convent pinopod diagnos woi guid person embryo transfer pet group rif patient rsert diagnos patient normal woi displac advanc accord pinopod patient found normal woi patient present delay growth pattern conduct pet patient rsert group higher success pregnanc rate requir fewer et cycl vs p studi prove poor consist diagnost tool endometri recept base cellular structur gene profil support rsert reliabl tool potenti clinic valu
|
D004717;D010064
|
T023;T040
|
36,339,408
|
optim diagnost criteria endogen hyperinsulinem hypoglycemia base larg cohort chines patient end fast insulin level iuml c peptid level ngml proinsulin level pmoll end fast glucos level mmoll establish criteria endogen hyperinsulinem hypoglycemia howev criteria propos base patient western popul studi aim determin optim criteria use larg seri chines patient
|
D010190;D044903
|
T047;T191
|
36,339,406
|
menopaus develop alzheim diseas role neural glucos metabol wnt signal late onset alzheim diseas ad neurodegen diseas gender differ onset progress preval predomin women earlier age men pathophysiolog menopaus condit associ dementia play major role regard endocrin glucos metabol chang amongst mechan current review address role estrogen defici process involv develop ad includ amyloid precursor protein app process form senil plaqu tau phosphoryl form neurofibrillari tangl wnt signal ad neuropatholog role glucos brain metabol wnt signal glucos transport brain research contribut topic
|
D000544;D019636
|
T047;T048
|
36,339,405
|
activ g protein coupl receptor keton bodi clinic implic ketogen diet metabol disord ketogenesi take place hepatocyt mitochondria acetyl coa deriv fatti acid catabol convert keton bodi kb name hydroxybutyr ohb acetoacet aceton kb repres import altern energi sourc metabol stress condit ketogen diet kds low carbohydr fat rich eat strategi wide propos valid nutrit intervent sever metabol disord due substanti efficaci weight loss achiev carbohydr restrict kd forc use ffa subsequ transform kb hepatocyt provid energi lead signific increas keton level known nutrit ketosi recent discoveri kb ligand g protein coupl receptor gpcr cellular transduc implic wide rang bodi function arous great interest understand whether clinic effect associ kd consumpt might mediat ketonegpcr axi specif anti inflammatori effect associ kd regimen presum due gpra mediat inhibit nlrp inflammasom ohb whilst lipid profil amelior kds could ascrib action acetoacet via gpr ohb via gpra lipolysi thus review focus effect kd induc nutrit ketosi potenti mediat specif gpcrs metabol endocrinolog disord discrimin effect keton bodi per se independ weight loss studi compar ketogen vs isocalor non ketogen diet consid well short term toler safeti kds
|
D055423;D007662
|
T061;T047;T046;T033
|
36,339,404
|
hypoxia activ unfold protein respons signal network adapt mechan endometriosi endometriosi em chronic gynecolog diseas affect women childbear age howev exact caus remain unclear uterus high vascular organ continu expos endometri cell high oxygen concentr accord plant theori em pathogenesi endometri cell fall uterin caviti retrograd periton caviti face sever hypox stress hypox stress remain key issu even success implant ovari peritoneum recent year increas evid confirm hypoxia close relat occurr develop em hypoxia induc factor hif play essenti role patholog process em regul carbohydr metabol angiogenesi energi convers ectop endometri cell howev hif alon insuffici achiev complet program adapt chang requir cell surviv hypox stress unfold protein respons upr respond endoplasm reticulum stress play essenti supplementari role promot cell surviv format complex signal regul network hypoxia driven upr may cytoprotect adapt mechan ectop endometri cell unfavor microenviron
|
D004715
|
T047;T191
|
36,339,403
|
associ bodi mass index pubert develop base outcom girl earli breast develop investig associ physic pubert develop base breast develop outcom girl
|
D007986;D011629
|
T125;T121;T047;T116
|
36,339,402
|
necroptosi new target prevent osteoporosi multipl caus may contribut osteoporosi character loss bone mass densiti consequ degrad bone microstructur result rise bone fragil recent increas attent paid role necroptosi develop osteoporosi necroptosi orchestr set protein known receptor interact protein kinas ripk ripk mix lineag kinas domain like protein mlkl necrosom form mlkl ripk ripk ripk ripk dissoci mlkl form pore plasma membran eventu lead necroptosi transloc necrosom review discuss detail understand necroptosi associ process better understand interact osteoclast osteoblast osteocyt associ necroptosi diabet osteoporosi steroid induc osteoporosi postmenopaus osteoporosi addit varieti experiment medicin capabl modul crucial necroptosi process highlight import note first review paper consolid current data role necroptosi osteoporosi offer fresh hope futur treatment diseas
|
D000079302;D010024
|
T047;T043
|
36,339,401
|
high level oxid fatti acid hdl impair antioxid function hdl patient diabet previous studi demonstr antioxid function high densiti lipoprotein hdl impair diabet patient composit hdl play import role maintain normal function hdl studi compar level oxid fatti acid hdl diabet subject non diabet healthi control aim investig role oxid fatti acid antioxid properti hdl
|
D008075;D003920
|
T123;T047;T116
|
36,339,400
|
cardiovascular abnorm correl genotyp children osteogenesi imperfecta osteogenesi imperfecta oi rare disord abnorm product modif type collagen caus mutat cola cola gene investig cardiac abnorm correl pathogen mutat oi children
|
D010013;D018376
|
T019;T047
|
36,339,399
|
genet condit short statur review three classic exampl noonan turner prader willi syndrom classic genet disord mark short statur disord recogn sever decad back extens publish literatur describ featur genet origin optim treatment strategi disord accompani multitud comorbid includ cardiovascular issu endocrinopathi infertil diagnost delay syndrom associ comorbid ineffici communic among member patient health care team affect patient well birth adulthood insuffici inform avail help patient multidisciplinari team provid transit pediatr adult health care system aim review summar clinic featur genet associ syndrom describ best practic diagnosi treatment emphas import multidisciplinari team appropri care plan pediatr adult health care transit
|
D060305;D011218
|
T058;T047
|
36,339,398
|
ultrastructur regul color chang blue spot leopard coral trout plectropomus leopardus leopard coral trout general exhibit numer round minut blue spot cover head size nostril bodi except ventral side characterist distinguish similar speci recent howev found leopard coral trout black spot distribut ultrastructur chromatophor blue black spot investig light transmiss electron microscopi result show blue spot two type chromatophor present dermi light reflect iridophor locat upper layer aggreg light absorb melanophor lower layer black spot similar chromatophor composit except melanosom within melanophor dispers dendrit process encircl iridophor interest treatment forskolin potent adenyl cyclas activ blue spot bodi surfac turn black hand use skin prepar vitro electr stimul norepinephrin treatment return spot blue color indic sympathet nerv involv regul color blue spot taken togeth result reveal blue spot leopard coral trout chang color black vice versa result differ distribut melanosom enrich understand bodi color color chang fish
|
D002856;D001492;D046009;D037421
|
T015;T025;T204;T013
|
36,339,397
|
identif analysi novel endometriosi biomark via integr bioinformat endometriosi gynecolog diseas preval women reproduct age character ectop presenc growth eutop endometrium pathophysiolog diagnost biomark endometriosi yet comprehens determin discov molecular marker pathway under pathogenesi endometriosi identifi differenti express gene deg three gene express omnibus microarray dataset gse gse gse perform gene set enrich analysi gsea protein protein interact ppi network analys also valid identifi gene via immunohistochem analysi tissu obtain patient endometriosi healthi volunt total deg upregul downregul detect dataset lower fold chang fc cutoff logfc gt deg upregul six downregul higher fc cutoff logfc gt kegg go function analys reveal enrich signal pathway associ inflamm complement activ cell adhes extracellular matrix endometriot tissu upregul seven gene c cfh fzd ly pdlim ptgis wisp valid via comparison extern gene set protein express four gene ly pdlim ptgis wisp analyz immunohistochemistri western blot analysi base result suggest tlrnf b wntfrizzl signal pathway well estrogen receptor regul progress endometriosi pathway may therapeut diagnost target endometriosi
|
D004715
|
T047;T191
|
36,339,396
|
lobectomi may appropri patient earli stage medullari thyroid cancer older year old clinic guidelin present recommend total thyroidectomi treatment medullari thyroid cancer mtc studi aim investig whether lobectomi could initi treatment stage mtc patient
|
D013964;D018278
|
T191
|
36,339,395
|
overview deep learn applic precoci puberti thyroid dysfunct last decad deep learn method garner great deal attent endocrinolog research articl provid summari current deep learn applic endocrin disord caus either precoci onset adult hormon abnorm amount hormon product give access broader audienc start gentl introduct deep learn common use architectur focus research trend deep learn applic thyroid dysfunct classif precoci puberti diagnosi highlight strength weak various approach discuss potenti solut differ challeng also go practic consider use choos build deep learn model well understand thought process behind differ decis made model final give conclud remark futur direct
|
D011629;D000077321
|
T047;T066
|
36,339,347
|
choos cellular model studi sar cov new pathogen emerg new challeng must face differ infecti diseas research identifi best tool avail laboratori conduct investig least initi particular complic howev context emerg virus sar cov recent detect china becom global threat healthcar system develop model infect pathogenesi urgent requir cell base approach crucial understand coronavirus infect biolog growth kinet tropism usual laboratori cell line first line experiment model studi viral pathogen perform assay aim screen antivir compound effici block replic emerg virus save time resourc reduc use experiment anim howev determin ideal cell type challeng especi sever research adapt studi specif requir review strive guid scientist ventur studi sar cov help choos right cellular model revisit basic concept virolog present current avail vitro model advantag disadvantag known consequ choic
|
D000086402;D000086382
|
T005;T067;T047
|
36,339,346
|
biolog characterist genom analysi novel vibrio parahaemolyticus phage phiti isol coastal water xiamen china vibrio parahaemolyticus common pathogen usual control antibiot maricultur notabl tradit antibiot therapi becom less effect emerg bacteri resist henc new strategi need found overcom challeng bacteriophag class virus lyse bacteria help us control drug resist bacteria studi novel vibrio parahaemolyticus phage phiti isol coastal water xiamen explor transmiss electron microscopi show phiti icosahedr head nm diamet contractil tail length nm phage titer could reach pfuml optim moi phage phiti degre toler heat acid base temperatur c ph h surviv phage reach pfuml ph c h surviv phage greater pfuml analysi phage one step growth curv reveal latent period min rise period min averag burst size phage pfucel genom sequenc analysi drew phage phiti doubl strand dna bp gc content contain open read frame orf trnas phylogenet tree base major capsid protein mcp reveal phage phiti mw high relat two vibrio phage phikt om va mk ncbi align result show nucleotid sequenc ident respect addit proteom tree analysi indic phage phiti phikt va belong virus sub cluster within myovirida studi provid theoret basi understand genom characterist interact vibrio parahaemolyticus phage host
|
D001435;D014736
|
T005;T007
|
36,339,345
|
develop multiplex cross displac amplif combin later flow biosensor assay detect virul shigella sonnei shigella sonnei common shigella spp develop area second common undevelop region studi multipl cross displac amplif mcda assay use combin later flow biosensor lfb assay detect virul sonnei strain contain ipah wbgx gene multiplex mcda lfb assay detect wbgx pgl ipah fgl within min pure cultur maintain c assay sensit cfu virul sonnei cfu shigella spp enteroinvas e coli stimul fecal sampl specif among refer strain mcda lfb assay also abl differenti virul sonnei shigella spp enteroinvas e coli among clinic isol summari multiplex mcda lfb assay develop rapid conveni point care accur identif virul sonnei within min constant temperatur without need expens lab equip
|
D015374;D012760
|
T007;T059;T075
|
36,339,344
|
clinic perform metagenom next generat sequenc rapid diagnosi talaromycosi hiv infect patient talaromycosi invas endem mycosi caus dimorph fungus talaromyc marneffei marneffei tm main affect immunodefici patient especi hiv infect individu caus signific morbid mortal cultur base diagnosi take long turnaround time low sensit lead treatment delay studi aim evalu perform metagenom next generat sequenc mngs rapid diagnosi talaromycosi hiv infect patient
|
D060085;D020031;D015658
|
T047
|
36,339,343
|
engin ht produc gut probiot improv gastrointestin motil behavior disord slow transit constip intract constip unknown aetiolog uncertain pathogenesi gut microbiota maintain symbiot relationship host impact host metabol previous studi report gut microb abil produc hydroxytryptamin ht import neurotransmitt howev scarc data exploit effect gut microbiota deriv ht constip relat diseas genet engin probiot escherichia coli nissl ecn ht synthes ht situ abil ecn ht secret ht vitro vivo confirm examin effect ecn ht intestin motil loperamid induc constip mous model two week ecn ht oral gavag constip relat symptom reliev gastrointestin motil enhanc meanwhil administr ecn ht allevi constip relat depress like behavior also observ improv microbiota composit ecn ht treatment work suggest gut microbiota deriv ht might promis potenti therapeut strategi constip relat behavior disord
|
D019936;D001523
|
T007;T048
|
36,339,341
|
clonorchi sinensi infect induc hepatobiliari injuri via disturb sphingolipid metabol activ sphingosin phosphat receptor clonorchi sinensi c sinensi infect induc sever hepatobiliari injuri caus inflamm periduct fibrosi even cholangiocarcinoma sphingolipid metabol pathway respons generat sphingosin phosphat sp receptor sp receptor sprs implic mani liver relat diseas howev role sprs c sinensi mediat biliari epitheli cell bec prolifer hepatobiliari injuri elucid present studi found c sinensi infect result alter bioactiv lipid sphingolipid metabol pathway mice liver furthermor spr predomin activ among sprs bec vivo vitro use jte specif antagonist spr found hepatobiliari patholog injuri inflamm bile duct hyperplasia periduct fibrosi signific inhibit c sinensi infect mice addit c sinensi excretori secretori product csesp sp induc activ akt erk inhibit jte bec therefor sphingolipid metabol pathway spr play import role may serv potenti therapeut target hepatobiliari injuri caus c sinensi infect
|
D003003;D003004;D001650
|
T047;T191;T204
|
36,339,340
|
featur cytomegalovirus infect evalu cytomegalovirus specif cell therapi children patient follow allogen hematopoiet stem cell transplant retrospect singl center studi cytomegalovirus cmv infect remain critic caus mortal allogen hematopoiet stem cell transplant allo hsct despit improv pre emptiv antivirus treatment cmv specif cytotox lymphocyt cmv ctl univers use proven well toler allo hsct adult clinic trial howev comprehens evalu children patient herein conduct retrospect studi determin risk factor cmv infect evalu cmv ctl children patient underw allo hsct result signific poor year overal surviv found cmv infect group vs p haploident hsct haplo hsct identifi independ risk factor cmv infect univari multivari analys p lt p respect furthermor cumul incid cmv infect statist higher haplo hsct group compar hla match donor group vs p lt final overal respons rate cmv ctl patient cmv infect allo hsct conclud cmv infect follow allo hsct correl increas mortal children patient haplo hsct independ risk factor cmv infect adopt cmv ctl cell therapi safe effect pediatr patient cmv infect
|
D003586;D018380
|
T061;T047
|
36,339,339
|
alter gut microbiota aid patient pneumocysti pneumonia correl lung microbiota due inabl cultur vitro biolog characterist pathogen pneumocysti jirovecii remain unclear intestin microflora disord relat occurr develop various pulmonari diseas work explor pathogenesi pneumocysti pneumonia pcp acquir immun defici syndrom aid patient microbiom perspect provid better strategi diagnosi treatment prevent pcp
|
D011020;D000069196;D000163;D015658;D064307
|
T032;T007;T028;T047;T001
|
36,339,338
|
stabl reconstruct human gingiva microb interact model differenti respons commens pathogen investig human oral health diseas model requir repres interact oral mucosa microbiom aim develop organotyp model maintain viabil host microb extend period time
|
D005881;D053492
|
T123;T023;T116;T024
|
36,339,337
|
pattern recognit receptor signal innat immun respons schistosom infect schistosomiasi remain signific public health problem tropic subtrop region despit remark progress made control diseas past decad elimin remain daunt challeng mani countri diseas inflammatori respons driven posit outcom infect depend regul immun respons effici clear worm allow protect immun develop innat immun respons play critic role host defens schistosom infect pathogenesi initi pro inflammatori respons essenti clear invad parasit promot appropri cell mediat humor immun howev elev prolong inflammatori respons egg trap host tissu contribut diseas progress better understand molecular mechan innat immun respons import develop effect therapi vaccin updat recent advanc definit host innat immun respons schistosom infect especi highlight critic role pattern recognit receptor cytokin consider research also provid
|
D012552;D014612
|
T129;T047;T121;T116
|
36,339,336
|
diagnost accuraci metagenom next generat sequenc cryptococcosi immunocompet immunocompromis patient compar diagnost accuraci metagenom next generat sequenc mngs cryptococcosi patient differ immun status convent detect
|
D007376;D003453
|
T129;T047;T121;T116
|
36,339,335
|
proteus mirabili klebsiella pneumonia pathogen capabl caus co infect exhibit similar virul factor genera klebsiella proteus independ describ gram negat rod colon human intestin tract regard main reservoir opportunist pathogen favor condit caus infect often hospit acquir one activ k pneumonia p mirabili lead pathogen within genus result infect urinari uti respiratori tract wound bacteremia affect main immunocompromis patient p mirabili k pneumonia caus polymicrobi uti often persist due cathet biofilm format increas resist bacteria antibiot situat need aris find antigen featur common speci among mani virul factor produc pathogen ureas show structur similar biggest similar observ lipid core region lipopolysaccharid lpss speci produc capsular polysaccharid cpss k pneumonia antigen play crucial role serolog classif scheme proteus spp base structur serolog divers lps polysaccharid opss structur serolog similar observ klebsiella spp proteus spp polysaccharid import search cross react vaccin antigen
|
D060085;D014552
|
T047
|
36,339,334
|
ngs clinic microbiolog set hypothes target ngs sequenc might advantag sanger sequenc especi polymicrobi infect studi includ specimen patient compar target ngs sanger sequenc clinic sampl submit sanger sequenc overal concord rate ngs vs sanger ngs identifi polymicrobi monomicrobi infect among sanger negat sampl polymicrobi infect sampl gene identifi gel electrophoresi could map identifi pathogen sanger estim ngs could contribut patient manag evalu patient thus advantag sanger sequenc certain polymicrobi infect
|
D059014;D060085
|
T063;T047;T059
|
36,339,333
|
research childhood tuberculosi suspect popul molecular method multicent studi china research childhood tuberculosi inadequ china cross prime amplif cpa specif dna clinic sampl increas adopt diagnosi childhood tuberculosi studi multicent research perform investig incid characterist childhood tuberculosi suspect popul main cpa method children suspect tuberculosi enrol seven center across china sampl test cpa method subject test xpert mtbrif liquid cultur method parallel assess reliabl cpa method posit result one three method provid definit diagnosi mycobacterium tuberculosi complex mtbc infect mtbc posit rate combin method case detect cpa technolog rate pulmonari infect signific higher extrapulmonari infect vs p lt scrofula predomin type extrapulmonari tuberculosi mtbc posit rate year old group middl school higher six year old preschool year old primari school group combin p lt mtbc posit rate patient clear histori tuberculosi exposur signific higher case histori tuberculosi contact vs p lt conclus multicent investig show pulmonari tuberculosi extrapulmonari tuberculosi uncommon children china teenag particular suscept infect incid pulmonari tuberculosi children higher extrapulmonari tuberculosi histori exposur tuberculosi high risk factor childhood tuberculosi
|
D009169;D014376;D014397
|
T047;T007
|
36,339,332
|
develop evalu rapid sensit multienzym isotherm rapid amplif later flow dipstick assay detect acinetobact baumannii spike blood specimen studi aim establish multienzym isotherm rapid amplif later flow dipstick mira lfd assay evalu perform detect baumannii spike blood specimen
|
D040981
|
T007
|
36,339,331
|
evid spread sar cov olfactori cell lineag impair close contact infect syrian hamster model close contact patient covid specul common caus viral transmiss pathogenesi covid close contact remain elucid addit despit olfactori impair uniqu complic covid impact sar cov olfactori cell lineag fulli valid studi aim elucid close contact viral transmiss nose lung investig tempor damag olfactori receptor neuron orn lineag caus sar cov
|
D000086382;D000857
|
T033;T047;T067
|
36,339,330
|
novel stat loss function mutat associ mendelian suscept mycobacteri diseas mendelian suscept mycobacteri diseas msmd rare congenit immun defici character suscept weak virul mycobacteria loss function lof mutat signal transduc activ transcript stat one common genet caus msmd studi identifi patient present multipl lymph node enlarg multipl osteolyt disrupt mycobacterium gordona infect confirm metagenom next generat sequenc whole exom sequenc identifi novel patern heterozyg mutat exon stat nm ct gt c pvalala variant confirm pathogen multipl softwar predict base function assay stat express statva cell differ statwt cell statva mutat caus much lower activ stat stimul interferon ifn fluoresc local analysi reveal statva statwt protein locat cytoplasm statva protein transloc nucleus respons ifn result suggest statva lead lof ifn mediat mycobacteri immun result msmd treatment antibiot achiev ideal diseas control patient advers event occur follow stat lof defici genet caus msmd consid patient mycobacteri diseas especi bone involv
|
D009164;D009161
|
T047;T007
|
36,339,279
|
pharmacolog intervent versus combin treatment depress prospect studi depress common diseas worldwid still role combin treatment pharmacolog psycholog intervent need clarifi studi aim compar effect integr treatment versus exclus pharmacolog intervent depress
|
D003863;D011613
|
T061;T184;T048
|
36,339,277
|
probabl risperidon associ acut pancreat child adhd psychotrop induc pancreat rare even rarer pediatr popul author report interest case risperidon induc pancreat child adhd comorbid conduct disord clinician mind remot yet serious side effect
|
D001289;D010195;D019955
|
T047;T046;T048
|
36,339,276
|
one hundr cours cluster mainten transcrani magnet stimul cm tms clinic audit studi major depress disord mdd come transcrani magnet stimul tms prone relaps cluster mainten cm tms cours treatment deliv day separ month greater non treatment period aim character outcom cours cm tms
|
D050781;D003865
|
T062;T048;T061
|
36,339,275
|
random doubl blind control clinic trial omega fatti acid inositol monotherapi combin treatment pediatr bipolar spectrum disord children age aim studi assess efficaci toler omega fatti acid fas inositol alon combin treatment pediatr bipolar bp spectrum disord young children
|
D001714;D014150;D015525
|
T121;T123;T109;T039;T048
|
36,339,274
|
associ cypd polymorph steadi state concentr haloperidol patient alcohol induc psychot disord cypd subfamili isoenzym play import role biotransform haloperidol activ may influenc efficaci safeti haloperidol use haloperidol often associ occurr advers drug reaction adr dyskinesia acut dystonia orthostat hypotens previous studi demonstr relationship cypd genet polymorph cypd activ well haloperidol efficaci safeti rate
|
D011604;D014150;D011618
|
T121;T039;T048
|
36,339,273
|
impact pharmacophobia pharmacophilia percept medic use self medic behavior saudi arabia pharmacophilia pharmacophobia posit negat effect treatment outcom exist lacun inform phenomena middl east countri therefor current studi aim determin pattern predictor pharmacophilia pharmacophobia saudi arabia studi explor impact phenomena percept medic use self medic behaviour
|
D012651;D010465
|
T055;T041
|
36,339,272
|
agomelatin monotherapi autism case report asd common associ host challeng behaviour pharmacotherapi indic psycho social educ intervent fail atyp antipsychot strongest evid base far risperidon aripiprazol fda approv unfortun use fraught metabol neuro hormon side effect author report case asdmild id behaviour dyscontrol fail multipl psychotrop trial ultim respond favour agomelatin monotherapi achiev excel toler might open new venu complic case
|
D001321;D000067877;D014150
|
T121;T039;T048
|
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