PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,253,727 | self perceiv burden predict lower qualiti life advanc cancer patient mediat role existenti distress anxieti self perceiv burden spb import predictor qualiti life qol patient advanc cancer howev mechan spb affect patient qol remain unclear studi aim examin potenti mediat role existenti distress ed anxieti relationship spb qol | D009369;D011788 | T078;T191 |
36,253,726 | clinic applic machin learn predict shape human bodi systemat review predict morpholog chang anatom structur shape blood vessel appear face grow interest clinician machin learn ml great success drive predict howev method suitabl shape unclear use case unknown | D018594;D000069550 | T023;T016;T066 |
36,253,725 | risk morbid mortal neurosurgeri older patient high grade glioma retrospect popul base studi although high grade glioma larg affect older patient current evid neurosurg complic most base studi includ younger studi popul aim investig risk postop complic neurosurgeri popul base cohort older patient high grade glioma explor chang time | D001932;D005910;D009493 | T191;T091 |
36,253,724 | gene identif express analysi molecular dock atp sulfurylas selen pathway cardamin hupingshanensi atp sulfurylas atp crucial enzym selen assimil pathway plant | D017360;D031217;D012643 | T123;T196;T121;T002 |
36,253,723 | web base databas server use public rna seq sampl analysi gene express altern splice livestock anim livestock anim great signific agricultur product howev role specif gene express especi altern splice determin phenotyp well understood livestock research communiti need gene express altern splice databas contribut livestock genet improv | D017398;D058751 | T045;T008;T123;T114 |
36,253,721 | tumor microenviron relat gene selenium bind protein selenbp associ immunotherapi efficaci surviv colorect cancer selenium bind protein selenbp member selenium contain protein famili play import role malign tumorigenesi progress howev current lack research relationship selenbp immunotherapi colorect cancer crc | D015179;D012643 | T121;T123;T196;T191 |
36,253,719 | reduc risk infant mortal midland uk qualit studi identifi area improv deliveri key public health messag perinat period midland amongst highest rate neonat infant mortal uk public health parent educ empower programm aim reduc key risk associ mortal establish evalu region undertaken attempt identifi area optim deliveri public health messag around reduc risk neonat infant mortal | D006266;D007226;D010290 | T081;T099;T102;T065;T058 |
36,253,718 | time optim gadobutrol enhanc brain mri metastas primari tumor use dynam contrast enhanc imag recent advanc rapid imag techniqu necessit reconsider optim imag delay time contrast enhanc weight imag aim studi determin optim contrast enhanc weight imag delay time obtain time signal intens curv tic use gadobutrol patient brain metastas primari brain tumor meningioma | D001932;D008577;D008579;D009942 | T191;T109 |
36,253,717 | effect intraven lidocain ed propofol insert gastroscop without bodi movement adult patient random control studi circulatori respiratori depress common problem occur propofol alon sedat gastroscopi wide use analges adjuv intraven lidocain reduc consumpt propofol endoscop retrograd cholangiopancreatographi ercp colonoscopi howev still unknown median effect dose ed propofol combin lidocain intraven studi aim compar ed propofol without intraven lidocain insert gastrointestin endoscop success | D015742 | T121;T109 |
36,253,716 | assess postpartum haemorrhag placenta accreta measur myometrium thick dark intraplacent band use mri help studi aim investig predict valu magnet reson imag mri myometri thick grade dark intraplacent band dib volumetri blood loss patient placenta accreta spectrum pas | D010921;D006473 | T046 |
36,253,714 | arteri glyceryl trinitr acut ischem stroke thrombectomi neuroprotect rational design protocol prospect random control trial although endovascular recan therapi demonstr robust clinic efficaci acut ischem stroke ai victim cerebrovascular accid benefit achiev favor prognosi success reperfus therefor altern neuroprotect strategi urgent need ai patient vessel recan nitric oxid level low ai donor drug may neuroprotect cerebr ischemia reperfus injuri glyceryl trinitr gtn often use clinic donor may provid novel neuroprotect strategi rational design protocol prospect pilot studi plan explor preliminari safeti feasibl neuroprotect benefit arteri glyceryl trinitr acut ischem stroke thrombectomi neuroprotect | D002545;D000083242;D020521 | T047;T046 |
36,253,713 | untarget metabolom analysi reveal mycobacterium tuberculosi strain hrv specif induc tryptophan metabol human macrophag tuberculosi tb caus mycobacterium tuberculosi tb remain global health issu character virul tb hrv avirul tb hra bcg strain wide use refer strain investig mechan tb pathogen attempt determin metabolom signatur associ mycobacteri virul human macrophag comparison metabolit profil thp deriv macrophag follow exposur tb hrv tb hra bcg strain | D009169;D014376 | T047;T007 |
36,253,712 | hotspot sequenc gyra gyrb parc pare gene encod fluoroquinolon resist local salmonella typhi strain jakarta infect salmonella enterica subsp enterica serovar typhi primari etiolog typhoid fever global common mani develop countri especi dens popul poor environment sanit antibiot fluoroquinolon use treatment due resist first line antibiot howev mani case treatment failur fluoroquinolon typhoid patient report numer countri asia europ africa america mutat quinolon resist determin region qrdr gene gyra gyrb parc pare found fluoroquinolon resist salmonella typhi contrast report came typhi isol indonesia main jakarta surround obtain patient typhoid fever good sensit fluoroquinolon ie nalidix acid ciprofloxacin moxifloxacin levofloxacin present studi therefor aim identifi hotspot sequenc gyra gyrb parc pare gene local typhi strain base suscept fluoroquinolon patient typhoid fever jakarta satellit citi | D015363;D019779;D014435 | T047;T007;T109 |
36,253,710 | deep learn approach cancer subtyp classif use high dimension gene express data studi shown classifi cancer subtyp provid valuabl inform rang cancer research aetiolog tumour biolog prognosi person treatment current method usual adopt gene express data perform cancer subtyp classif howev cancer sampl scarc high dimension featur gene express data spars allow method achiev desir classif result | D000077321;D009369 | T191;T066 |
36,253,656 | assess human induc effect sultan marsh ramsar protect kayseri turkey studi examin dri sultan marsh spatio tempor chang differ land cover class corin land cover chang output examin four period analys period water area chang lake occur determin moreov land cover chang occur region defin lcc result compar discuss term human factor ie human develop index terrestri human footprint accord result studi observ sever declin lake surfac water locat sultan marsh nation park area water surfac lake decreas compar previous year decreas withdraw promin especi lake yay lake l consid human factor human develop index variabl terrestri human footprint term spatio tempor land cover chang seen human develop region increas human footprint increas water area chang occur high rate result grow demand basic need water consumpt food divers increas human develop expand agricultur practic region overus ground aboveground water sourc lake especi high number human intervent region caus human footprint higher unless sultan marsh proper plan polici face danger complet dri effect climat chang futur | D003247;D053833 | T078;T070;T083;T069;T081;T064 |
36,253,654 | ecotoxicolog assess estuarin surfac water receiv treat untreat sanitari wastewat pollut sewag discharg one critic environment problem worldwid eg brazil basic sanit still scarc pollut affect biom especi estuari intens ecolog human activ occur caus widespread concern work aim studi water qualiti jundiapotengi estuari jpe area close discharg treat untreat wastewat month physicochem microbiolog paramet measur integr use water qualiti index canadian council minist environ ecotoxicolog test perform brazilian endem organ assess impact water pollut biota general linear regress model appli understand effect water qualiti ecotoxicolog respons concentr metal dissolv oxygen total ammonia nitrogen nitrat thermotoler coliform compli brazilian environment regul signific increas mortal rate mysidopsi junia nitocra sp signific decreas reproduct rate nitocra sp indic affect area relat discharg treat untreat wastewat sampl site without direct wastewat impact show toxic respons least one organ water qualiti sampl site statist predictor ecotoxicolog respons describ pollut load also type effluent studi demonstr degrad environment qualiti jpe particular due discharg sanitari wastewat highlight import protect remedi measur preserv protect area | D004785;D014874 | T131 |
36,253,653 | chlamydia psittaci faecal sampl feral pigeon columba livia forma urbana urban area lublin citi poland pigeon typic host natur reservoir chlamydia psittaci etiolog agent avian chlamydiosi consid neglect zoonot diseas aim studi determin preval c psittaci faecal sampl feral pigeon columba livia forma urbana potenti sourc infect relat presenc synanthrop bird urban area total sampl dri fresh faec feral pigeon collect citi lublin poland april septemb molecular detect c psittaci perform nest pcr real time pcr confirm sequenc among collect sampl posit result obtain nest pcr real time pcr number posit sampl increas posit sampl show ident c psittaci strain amk cp c psittaci found faecal sampl collect public place sampl nest site among total sampl respect infect detect dri fresh faec respect highest number posit result obtain june feral pigeon occur urban area natur reservoir c psittaci pose potenti risk zoonot infect howev studi exposur contamin pigeon faec term occup non occup risk chlamydiosi need | D001715;D002691;D009956 | T047;T007 |
36,253,652 | effect berberin blue led irradi combat biofilm pseudomona aeruginosa staphylococcus aureus nowaday increas resist microorgan drug necessari look new solut besid antibiot therapi one effect approach use plant compound blue led irradi berberin alkaloid compound sever properti includ antibacteri effect compound destroy bacteri cell produc reactiv oxygen speci ros studi combin effect blue led irradi berberin pseudomona aeruginosa gram negat staphylococcus aureus gram posit also effect human dermal fibroblast hdf cell investig obtain result show combin berberin blue light irradi better effect bacteria antimicrobi effect higher gram posit bacteria compound also prevent format biofilm abl destroy creat biofilm therefor method suggest treat infect chronic wound diabet wound | D001599;D013203 | T121;T047;T109 |
36,253,651 | use cufe biochar composit remov methylen blue methyl orang tartrazin dye wastewat use photo fenton process studi cufe ferrit support biochar produc malt biomass residu photocatalyst degrad methylen blue mb methyl orang mo tartrazin tz dye xrd ft ir fe sem use character crystallin morpholog sampl character show ferrit uniform support surfac biochar confirm format composit degrad test show cufe degrad approxim mb mo tz dye respect min reaction hand cufe biochar composit show signific increas dye degrad three dye increas degrad effici may due less agglomer support particl due decreas recombin electronhol pair thus result show photocatalyst composit produc studi effect altern remov dye wastewat | D008751;D014874 | T121;T130;T131;T109 |
36,253,650 | compar physiolog genom hydrogen produc vibrio hyf type format hydrogen lyas fhl complex first propos base sequenc comparison escherichia coli andrew et al microbiolog hydrogenas hyf type fhl estim proton transloc energi conserv nife hydrogenas although structur fhl similar complex silent gene express e coli caus delay unveil genet biochem featur fhl entir set gene requir hyf type fhl synthesi also found genom sequenc vibrio tritonius matsumura et al int j hydrog energi produc hydrogen h e coli investig physiolog characterist genom comparison gene express elucid genet background hyf type fhl hyf type fhl correl higher h product v tritonius physiolog comparison among seven h produc vibrio reveal v porteresia v tritonius group porteresia clade show greater capac h product speci structur fhl hyp gene cluster close relat porteresia speci differ speci presenc hupe possibl nickel permeas gene interest deeper genom comparison reveal co presenc nickel abc transport gene nik hyf type fhl gene genom porteresia clade speci therefor activ primari ni transport might one key factor character higher h product v tritonius furthermor express fhl gene cluster signific regul v tritonius cell stimul format indic format like control factor gene express v tritonius fhl similar way format regulon encod e coli fhl | D006864;D014733 | T007;T126;T116 |
36,253,644 | estim skelet kinemat freeli move rodent form complet pictur relationship neural activ skelet kinemat requir quantif skelet joint biomechan free behavior howev without detail knowledg under skelet motion infer limb kinemat use surfac track approach difficult especi anim relationship surfac under skeleton chang motion develop videographi base method enabl detail three dimension kinemat quantif anatom defin skeleton unteth freeli behav rat mice skeleton base model constrain use anatom principl joint motion limit provid skelet pose estim rang bodi size even limb occlud model infer limb posit joint kinemat gait gap cross behavior verifi direct measur either limb placement limb kinemat use inerti measur unit togeth show complex decis make behavior accur reconstruct level skelet kinemat use anatom constrain model | D012377;D005684 | T033;T015 |
36,253,643 | omnipos high precis morpholog independ solut bacteri cell segment advanc microscopi hold great promis allow quantit precis measur morpholog molecular phenomena singl cell level bacteria howev potenti approach ultim limit avail method faith segment cell independ morpholog optic characterist present omnipos deep neural network imag segment algorithm uniqu network output gradient distanc field allow omnipos accur segment cell current algorithm includ predecessor cellpos produc error show omnipos achiev unpreced segment perform mix bacteri cultur antibiot treat cell cell elong branch morpholog furthermor benefit omnipos extend non bacteri subject vari imag modal three dimension object final demonstr util omnipos character extrem morpholog phenotyp aris interbacteri antagon result distinguish omnipos power tool character divers arbitrarili shape cell type imag data | D000465;D008853 | T170;T059 |
36,253,629 | assess pb ni potenti health risk associ consumpt veget grown roadsid soil district swat khyber pakhtunkhwa pakistan veget cultiv near road absorb toxic metal pollut soil enter human bodi food chain caus serious health problem human present studi investig concentr lead pb nickel ni soil veget grown along roadsid district swat pakistan health risk associ consumpt test veget result pb concentr higher plant locat distanc away roadsid permiss limit plant pb concentr higher ni rumex dentatus contain highest concentr pb mg kg dw among test veget ni concentr mg kg dw highest trachyspermum ammi compar plant concentr accumul metal decreas soil plant increas distanc road similar target hazard quotient valu note pb greater uniti show potenti risk associ consumpt test veget near road moreov valu target cancer risk greater show risk cancer consumpt test veget conclus consumpt test veget danger may lead higher risk cancer strict regulatori control recommend cultiv veget along roadsid avoid contamin due roadsid exhaust | D019216;D012989 | T131;T196 |
36,253,623 | barrier bridg water manag rural mexico water qualiti monitor water manag communiti level access suffici water suitabl qualiti repres challeng achiev sever dimens sustain develop current water access restrict three person global rural area mexico low incom countri coverag could even less due absenc formal suppli thus rural communiti usual perform water manag surround communiti base water manag various socio ecolog interact emerg determin access water access water depend obstacl capac aris within socio ecolog system communiti immers work identifi barrier bridg water access rural environ mix method articl draw three case studi southeastern mexico analyz questionnair conduct household level three focus group parallel water qualiti analysi relationship manag practic barrier bridg classifi six water access challeng access water suffici quantiti ii access water adequ qualiti iii access water household crop irrig iv hygien sanit facil v collect organ vi climat variabl main find indic household water quantiti qualiti show defici due lack formal infrastructur repres health risk water fetch highest impact women children poor rural area signific barrier sustain develop contrast collect organ prove essenti bridg water access communiti | D012424;D060753 | T033;T098;T102 |
36,253,621 | sphaerisporangium fuscum sp nov isol sediment anmucuo lake tibet autonom region china novel actinomycet strain design h isol lake sediment sampl polyphas approach employ determin taxonom posit phylogenet analysi base rrna gene indic strain h form monophylet clade within genus sphaerisporangium close relat sphaerisporangium siamens dsm similar sphaerisporangium rufum dsm similar draft genom length bp g c content averag nucleotid ident averag amino acid ident digit dna dna hybrid valu strain h close relat sphaerisporangium speci respect signific lower wide accept speci defin threshold diagnost diamino acid peptidoglycan meso diaminopimel acid whole cell sugar glucos ribos maduros menaquinon mk h mk h mk h mk phospholipid profil consist diphosphatidylglycerol phosphatidylglycerol phosphatidylethanolamin hydroxi phosphatidylethanolamin unidentifi phospholipid unidentifi aminophospholipid major fatti acid identifi iso c methyl c c result phenotyp properti genotyp distinct chemotaxonom featur indic strain h repres novel speci within genus sphaerisporangium sphaerisporangium fuscum spnov type strain h jcm cicc | D000192;D010714 | T123;T007;T109 |
36,253,620 | gut parabacteroid merda protect cardiovascular damag enhanc branch chain amino acid catabol obes dyslipidemia gut dysbiosi link cardiovascular diseas ganoderma meroterpen deriv gmd shown allevi obes hyperlipidemia modul gut microbiota obes mice show gmd protect obes associ atherosclerosi increas abund parabacteroid merda gut enhanc branch chain amino acid bcaa catabol administr live p merda high fat diet fed apo null male mice reduc atherosclerot lesion enhanc intestin bcaa degrad degrad bcaa mediat pora gene express p merda delet pora p merda blunt capac degrad bcaa lead inefficaci fight atherosclerosi show p merda inhibit mtorc pathway atherosclerot plaqu support preclin find silico analysi human gut metagenom studi indic p merda pora gene deplet gut microbiom individu atherosclerosi result provid mechanist insight therapeut potenti gmd p merda treat obes associ cardiovascular diseas | D002318;D050197 | T047;T046 |
36,253,618 | coxal genet variant determin cardiorespiratori fit mice human mitochondri respiratori complex form superassembl structur call supercomplex coxal supercomplex specif assembl factor mammal although implic supercomplex format cellular metabol remain controversi identifi role coxal mitochondri supercomplex format human use human cis express quantit trait loci data highlight genet variant coxal gene affect skelet muscl express specif signific cis express quantit trait locus bp insert coxal untransl region increas messeng rna stabil express human myotub harbor insert supercomplex increas respir notabl increas coxal express muscl associ lower bodi fat improv cardiorespiratori fit human accord specif reconstitut coxal express cblj mice lead higher maxim oxygen consumpt increas lean mass increas energi expenditur furthermor coxal express mice induc specif muscl upon exercis find elucid genet basi mitochondri supercomplex format function human show coxal play import role cardiorespiratori fit could broad therapeut implic reduc cardiovascular mortal | D000072599 | T040 |
36,253,617 | cdo promot ppar mediat adipos tissu lipolysi male mice cystein dioxygenas cdo key enzym taurin synthesi show cdo promot lipolysi adipos tissu adipos specif knockout cdo mice impair energi expenditur cold toler lipolysi exacerb diet induc obes dio decreas adipos express key lipolyt gene encod atgl hsl littl effect adipos taurin level white adipos specif overexpress atgl hsl blunt role adipos cdo defici promot dio mechanist cdo interact ppar facilit recruit med core subunit mediat complex atgl hsl gene promot therebi transactiv express mice transgen overexpress cdo show better cold toler amelior dio higher lipolysi capac thus uncov unexpect import role cdo regul adipos lipolysi | D008066;D047495 | T040;T116;T192 |
36,253,615 | influenc rosac speci drive factor differenti rhizospher bacteria decidu broad leav forest understand plant microb interact could provid basi improv phytoremedi microbi resourc util secondari metabolit product rhizospher bacteri communiti strong influenc abiot factor soil nutrient avail composit communiti exhibit differenti differ host plant decidu broad leav forest anhui provinc eastern china rhizospher bacteria three differ tree speci rosacea famili sorbus alnifolia cerasus serrulata photinia beauverdiana studi bacteria bulk soil control bacteri communiti composit determin use illumina platform high throughput sequenc rrna gene result show bacteri communiti composit vari rhizospher bulk soil domin bacteri phyla proteobacteria actinobacteria acidobacteria found soil inform predict function gene pathway reveal signific differ rhizospher bulk soil bacteria provid ampl evid differ metabol characterist rhizospher bacteri communiti three tree speci electr conduct total phosphorus concentr ureas activ main driver chang composit rhizospher bacteri communiti three tree speci | D058441;D012988 | T070;T067 |
36,253,614 | studi relationship diet physic health gut microflora chines colleg student mani element modern lifestyl influenc gut microbiota studi explor effect physic health level studi aim explor relationship diet physic health gut microbiota chines colleg student total colleg student recruit includ colleg athlet group healthi control hc group fecal sampl collect rrna sequenc accord nation standard student physic health revis physic fit measur dietari intak health relat data collect via questionnair accord physic fit score physic fit level group signific higher hc group p signific differ two group frequenc intak food frequenc durat physic activ group higher hc group p proport relat abund microorgan composit vari two group phylum level group main increas firmicut actinobacteria reduc bacteroidet proteobacteria genus level group main increas faecalibacterium bifidobacterium reduc bacteroid associ abund bacteri genera physic fit dietari factor investig chang gut microbiota abund sometim reflect physic health status loss balanc gut microbi popul lead flora disord diseas therefor studi need reveal mechan behind gut microbiota potenti role | D000069196 | T007;T001 |
36,253,613 | rapid detect strawberri mild yellow edg virus later flow strip revers transcript recombinas polymeras amplif assay strawberri mild yellow edg virus smyev latent virus sever affect yield qualiti strawberri fruit technolog suitabl rapid accur detect smyev site import effect control spread studi revers transcript recombinas polymeras amplif combin later flow strip smyev rt rpa lf target conserv genom beij smyev isol establish diagnos smyev strawberri smyev rt rpa lf assay show cross reaction strawberri virus sensit smyev rt rpa l assay time higher rt pcr pgl addit detect suspect sampl field found accuraci smyev rt rpa l assay consist rt pcr result howev compar rt pcr smyev rt rpa lf assay advantag simpl oper time save high specif sensit indic potenti applic smyev rt rpa lf rapid field diagnosi smyev | D031985;D048348 | T045;T168;T002 |
36,253,592 | effici biosorb remov arsenic typic urban generat wastewat arous environment concern due spike environment degrad necessit proper wast manag dispos arsenic potenti toxic element cassava wastewat requir treatment prior wastewat dispos minim environment pollut associ health implic present studi thus address treatment heavi metal cassava wastewat use effici biosorb chemic pretreat unshel moringa oleifera seed effect various factor influenc biosorpt process arsenat remov studi includ ph contact time biosorb dosag biosorb pretreat concentr result fourier transform infrar spectroscopi clear suggest addit function group attribut ester form pretreat biosorb respons improv biosorpt found contact time biosorb dosag biosorb pretreat concentr statist signific effect p valu arsenat remov maximum percentag remov achiev synthet solut ph contact time min dosag g biosorb pretreat chemic solut furthermor isotherm kinet studi discov biosorpt process untreat biosorb ion exchang treat biosorb indic multifari adsorpt mechan moreov biosorpt process exotherm spontan also note sorption capabl biosorb increas pretreat concentr statist model develop predict r incorpor effect treatment concentr percentag remov cassava wastewat | D001151;D014874 | T121;T196;T131 |
36,253,587 | level neurotic predict attent perform cross modal nonspati repetit inhibit inhibit return ior refer slower respons target present previous attend locat repetit induc inhibit found differenti associ person trait although well document person trait affect spatial ior mechan associ attent orient network yet consensus relationship person trait nonspati repetit inhibit mechan associ attent execut network present studi herein examin big five person trait relat cross modal nonspati repetit inhibit particip complet neo pi r perform cross modal nonspati repetit inhibit task built prime neutral cue target paradigm relationship ident modal prime target manipul result show signific nonspati inhibitori effect effect larger visual auditori condit auditori visual condit import neurotic associ decreas cross modal nonspati inhibitori effect presum due impair attent control howev result found visual auditori condit propos retriev previous prime represent visual auditori condit requir larg consumpt cognit resourc make inhibitori control difficult individu high neurotic find provid new insight influenc person trait attent perform requir nonspati inhibitori control enrich relationship neurotic repetit induc inhibit | D003463;D001288 | T078;T041 |
36,253,573 | antitumor immunotherapi sialic acid andor gm modifi coenzym q submicron emuls immunotherapi novel therapeut approach control kill tumor cell stimul reconstitut immun system among cell serv immun target herein use coenzym q coq immun activ avoid advers reaction model drug develop four coq submicron emuls modifi sialic acid sa andor monosialotetrahexosyl gangliosid gm one hand sa interact l selectin surfac cell enter circulatori system lead activ cell enhanc antitumor immun respons hand owe immun camouflag gm prolong circul time prepar bodi therebi increas accumul drug tumor site vitro vivo experi show sa modifi prepar exhibit stronger immun activ inhibit tumor prolifer pharmacokinet experi show gm modifi prepar longer circul time vivo howev sa gm co modif produc synergist effect prepar conclus sa modifi coq submicron emuls q se show optim antitumor efficaci administ medium dose mg coq kg studi submicron emuls model use carrier tumor bear mice use anim model addit coq submicron emuls modifi sa ch activ target function andor gm long circul function explor antitumor effect differ dose coq submicron emuls screen best tumor immunotherapi formul coq | D019158;D009369 | T123;T191;T109 |
36,253,571 | drug carrier miscibl solid dispers glibenclamid novel approach enhanc solubl use effervesc agent present research aim investig miscibl physic stabil solubl dissolut rate poor water solubl glibenclamid glb solid dispers sds hydrophil carrier like peg peg hydrogen palm glycerid acconon mathemat theori hansen solubl paramet flori huggin theori gibb free energi silico molecular dynam simul studi approach use predict drug carrier miscibl increas solubl effervesc techniqu introduc convent solid dispers prepar effervesc solid dispers esd solid dispers sds prepar microwav solvent evapor lyophil hot melt extrus hme techniqu test differ character paramet theoret silico paramet suggest glb would show good miscibl select carrier certain condit intermolecular hydrogen bond drug carrier confirm fourier transform infrar spectroscopi proton nuclear magnet reson spectroscopi solid state character like powder x ray diffract differenti scan calorimetri microscopi confirm amorph natur sds addit effervesc agent improv amorph natur due solubl drug releas rate increas vitro ex vivo intestin absorpt studi show improv flux permeabl pure drug suggest enhanc drug deliveri glb solubl dissolut stabil great enhanc sd esd technolog | D004337;D005905 | T121;T122;T109 |
36,253,569 | voltammetr immunoassay base mwcnts nd oh bsa antibodi platform sensit bsa detect electrochem approach present base multiwal carbon nanotub mwcnts neodymium iii hydroxid nd oh nanoflak detect bovin serum albumin bsa materi character morpholog xrpd sem hr tem electrochem dpv ei mwcnts nd oh composit use support bovin serum albumin polyclon antibodi anti bsa antibodi immobil electrochem platform antigenantibodi bind time optimum min propos approach show linear voltammetr respons toward bsa concentr rang ng ml maximum peak potenti v vs agagcl limit detect lod limit quantif loq pg ml pg ml respect precis method calcul relat standard deviat rsd five independ measur better select optim method regard structur similar protein human serum albumin human hemoglobin ion na k ca compound glucos ascorb acid dopamin uric acid paracetamol glycin found satisfactori current chang less presenc time higher concentr depend compound list potenti interf compound practic applic immunosensor bsa determin cow whey sampl recoveri valu rang show develop method high potenti precis accur detect bsa well except miniatur possibl site equip free sens | D015374;D037742 | T104;T059;T073;T075 |
36,253,568 | human cerebr organoid new tool clinic neurolog research current understand neurolog diseas deriv most direct analysi patient anim model diseas howev patient studi captur earliest stage diseas develop offer limit opportun experiment intervent rare yield complet mechanist insight use anim model reli evolutionari conserv pathway involv diseas limit inabl recreat human specif process vitro model deriv human pluripot stem cell cultur emerg new model system could bridg gap patient studi anim model review summar organoid model complement classic approach acceler neurolog research describ current understand neurodevelop process differ human anim make human deriv model diseas essenti discuss differ methodolog produc organoid organoid use model neurolog disord includ microcephali zika virus infect alzheim diseas neurodegen disord neurodevelopment diseas timothi syndrom angelman syndrom tuber sclerosi also discuss current limit organoid model outlin organoid use revolution research human brain neurolog diseas | D008831;D019636;D000071243;D000071244;D009462 | T019;T047;T091;T005 |
36,253,567 | occurr ecolog risk assess antibiot residu urban wastewat discharg coastal environ persian gulf case bandar abba first attempt detect antibiot residu releas persian gulf marin environ particular studi quantifi assess ecolog risk amoxicillin amx azithromycin azm residu wastewat outfal bandar abba one major coastal citi southern iran wastewat effluent sampl collect two main wastewat discharg station gursuzan suru decemb februari high perform liquid chromatographi hplc analysi reveal averag concentr cl amx g l g l gursuzan suru station mean azm concentr also g l g l station respect pool data indic g amx azm residu wastewat per liter valu potenti ecolog risk hazard quotient hq extens amx azm suggest substanc high health risk ecosystem public given bandar abba wastewat treatment plant wwtp outlet discharg l daili maximum potenti amx azm releas estim g day respect find show concern volum antibiot residu releas northern persian gulf henc urgent polici action necessari reduc pollut | D062065;D014874 | T131;T083;T069 |
36,253,562 | surfac character tool identifi factor affect dissolut rate amorph solid dispers tablet amorph solid dispers asd common use approach enhanc dissolut poor aqueous solubl drug select desir polym drug load time consum surfac properti surfac composit wet behavior essenti factor control dissolut asd tablet thus studi aim use surfac character understand factor affect dissolut rate asd tablet work prepar asd itraconazol hypromellos acet succin hpmcas use spray dri asd prepar use three grade hpmcas differ drug load level prepar asd tablet two poros tablet contact angl measur use drop shape analyz surfac free energi dispers polar fraction calcul base contact angl conduct near infrar nir dissolut measur asd tablet princip compon analysi pca carri investig nir spectra relat pca score report sampl properti partial least squar pls model use nir score tablet wet properti dissolut rate reveal water buffer contact angl surfac free energi polar fraction signific factor attribut dissolut rate asd tablet work understood interplay surfac properti dissolut rate asd tablet moreov surfac character tool screen formul compact process asd tablet earli develop | D017964;D011108 | T121;T122;T104;T109 |
36,253,557 | spatial pattern tempor variat pollut air qualiti monitor station state paulo brazil studi appli two data mine task cluster associ rule dataset pollut state paulo cluster task appli tempor pattern geospati distribut pollut associ rule use identifi prevail meteorolog condit high concentr pollut result indic good adequaci cluster indic differ pollut level per group silhouett coeffici spatial evalu group sever pollut locat metropolitan region coast inland citi industri vehicular burn agricultur emiss cluster identifi strong presenc pm monitor station sever area state distanc sourc pollut group pm geograph distant pm co closer suggest spatial relationship exposur season similar group signific higher concentr winter except higher concentr occur summer meteorolog condit contribut critic episod pollut support confid greater low temperatur humid low rainfal milder wind associ increas pollut conclus investig spatial repres allow reveal spatial tempor pattern pollut unfavor meteorolog condit diffus thus ideal effect measur taken avoid critic period exposur base behavior pollut differ region relat climat chang | D000393;D000397;D004785 | T131;T069;T080 |
36,253,556 | acinetobact baumannii biofilm format associ antimicrobi resist prolong surviv desicc biofilm form multidrug resist acinetobact baumannii emerg global pathogen studi investig impact biofilm format baumannii antimicrobi resist prolong surviv desicc essenti effect infect control baumannii hospit set seventi eight clinic isol baumannii identifi antibiot suscept profil assess isol investig biofilm form abil h biofilm inhibitori concentr antibiot evalu select biofilm form isol determin influenc biofilm antibiot toler impact biofilm format desicc toler also evalu day result reveal baumannii clinic isol mdr non mdr overal isol form high biofilm h extent biofilm format get signific increas h isol form high biofilm observ erad matur biofilm requir thousandfold higher concentr antibiot mic biofilm form isol surviv prolong period desicc conclus find reveal mdr non mdr isol baumannii could form biofilm abiot surfac baumannii biofilm contribut endur presenc antimicrobi desicc condit signific troubl hospit patient care manag present find may offer insight develop prevent measur tackl biofilm associ baumannii infect | D000151;D040981 | T047;T007 |
36,253,544 | natur alien flora still carri legaci european coloni redistribut alien speci across globe acceler start european coloni european power respons deliber accident transport introduct establish alien speci throughout occupi territori metropolitan state show activ left last imprint global distribut alien plant specif investig four european empir british spanish portugues dutch structur current alien flora worldwid found composit similar higher expect among region occupi empir provid strong evid florist similar region occupi empir increas time region occupi network analysi suggest histor econom strateg import region similar alien flora across region occupi empir overal find european coloni histori still detect alien flora worldwid | D058865;D018595 | T078;T098 |
36,253,535 | human induc pluripot stem cell deriv salivari gland organoid model sar cov infect replic salivari gland act virus reservoir various infecti diseas report target sever acut respiratori syndrom coronavirus sar cov howev mechan under infect replic salivari gland still enigmat due lack proper vitro model show human induc salivari gland hisg generat human induc pluripot stem cell infect sar cov hisg exhibit properti similar embryon salivari gland valuabl tool function analysi gene develop orthotop transplant hisg engraft recipi site mice show matur phenotyp addit confirm sar cov infect replic hisg sar cov deriv saliva asymptomat individu may particip spread virus hisg may promis model investig role salivari gland virus reservoir | D000086382;D057026 | T047;T025;T067 |
36,253,525 | noradrenerg consolid social recognit memori mediat arrestin bias signal mous prefront cortex social recognit memori srm critic maintain social relationship increas surviv rate medial prefront cortex mpfc import brain area associ srm storag norepinephrin ne releas regul mpfc neuron intrins excit excitatori synapt transmiss howev role ne signal circuitri locus coeruleus lc pathway mpfc srm storag unknown found lc mpfc ne project bidirect regul srm consolid propranolol infus adrenerg receptor ar arrestin knockout mpfc disrupt srm consolid carvedilol blocker mild activ arrestin bias signal inject mice show signific suppress srm consolid impair srm consolid caus ar arrestin knockout mpfc rescu activ lc mpfc ne project howev impair srm inhibit lc mpfc ne project ar knockout mpfc restor activ arrestin signal pathway mpfc furthermor activ arrestin signal improv srm consolid age mice studi suggest lc mpfc ne project regul srm consolid arrestin bias ar signal | D009638;D011433 | T125;T121;T109 |
36,253,522 | explor associ anthropometr paramet serum triglycerid serum thyroid hormon young women establish link serum thyroid hormon panel triglycerid tg concentr non invas obtain measur anthropometr paramet young women may provid preliminari knowledg homeostasi metabol process bodi composit strateg role test paramet earli screen test assess health status appar healthi women period preced pregnanc studi conduct healthi femal student age year mean sd anthropometr indic bmi waist hip ratio fat calcul serum concentr thyroid hormon tsh ft ft determin use electrochemiluminesc immunoassay serum triglycerid tg commerci avail test associ establish serum tsh anthropometr indic healthi young women increas serum concentr ft ft tg found overweight subject ie bmi kgm p signific negat associ ft tg found underweight subject r p signific posit associ normal weight subject r p healthi young women differ bmi relat thyroid function opposit direct associ ft vs tg underweight compar normal weight young prepregn femal may suggest depend ft tg regul specif bmi depend metabol process | D009765;D013851 | T033;T047 |
36,253,519 | effect lifestyl risk behaviour cluster cardiovascular diseas among uk adult latent class analysi distal outcom lifestyl risk behaviour smoke physic inact unhealthi diet account consider diseas burden global risk behaviour tend cluster within individu could detriment health effect studi aim examin cluster effect lifestyl risk behaviour cardiovascular diseas cvd cvd risk among adult unit kingdom uk perform latent class lc analysi distal outcom use uk biobank baselin data first estim lc measur model follow auxiliari model condit lc variabl report continu mean differ md binari odd ratio outcom confid interv includ uk adult data cvd cvd risk respect multipl lifestyl risk behaviour cluster physic inact poor fruit veget intak high alcohol intak prolong sit mean increas cvd risk compar high alcohol intak addit adult three risk behaviour physic inact poor fruit veget intak high alcohol intak higher odd cvd two risk behaviour physic inact poor fruit veget intak social depriv gender age also associ cvd individu lc membership two lifestyl risk behaviour negat affect cvd intervent target multipl lifestyl behaviour social circumst priorit reduc cvd burden | D002318 | T047 |
36,253,512 | cell biolog archaea past decad reveal divers ubiqu archaea natur grow number studi highlight import ecolog biotechnolog even human health myriad lineag discov expand phylogenet breadth archaea reveal central role evolutionari origin eukaryot discoveri coupl advanc enabl cultur live imag archaeal cell extrem environ underpin better understand biolog review focus shape intern organ surfac structur characterist archaeal cell well membran remodel cell growth divis also highlight technic challeng face discuss new improv technolog help address mani key unansw question | D001105;D005075 | T194;T045 |
36,253,507 | identif potenti megalincubilin substrat use extens proteom quantif kidney megalin knockdown mice megalin cubilin endocyt protein present proxim tubul kidney respons reabsorb filter protein urin hypothesi potenti substrat megalincubilin could identifi examin urinari protein differ control wt mice kidney specif megalin knockdown kd mice use ionstar proteom approach potenti megalincubilin substrat discov compound repres known megalincubilin substrat protein largest fold chang urin kd wt includ known megalin substrat retinol bind protein vitamin bind protein total protein identifi novel substrat three quarter compound molecular weight mws kda mw albumin remain higher mws protein mws greater kda sex differ number identifi substrat occur may due differ kidney megalin express male femal megalin kd wt anim ratio megalin wt kd femal male mice respect top three ingenu canon pathway base urinari protein femal male kd mice acut phase respons signal liver x receptorretinoid x receptor activ intrins prothrombin activ pathway conclus analysi urin sampl kidney specif megalin kd wt mice found use identif potenti endogen substrat megalin cubilin | D026561;D014809 | T123;T116;T192 |
36,253,499 | chang metamorphopsia follow intravitr aflibercept inject diabet macular edema aim present studi investig chang metamorphopsia patient diabet macular edema dme follow intravitr aflibercept inject iva treat extend tae regimen year perform post hoc analysi multicent open label singl arm prospect studi studi includ patient dme eye receiv month load inject mg aflibercept follow tae regimen everi visit sever metamorphopsia best correct visual acuiti bcva evalu optic coher tomographi oct imag obtain sever metamorphopsia measur use chart metamorphopsia score treatment month follow treatment respect signific improv treatment month follow treatment p p respect time macular edema resolut presenc epiretin membran erm associ metamorphopsia score p conclus metamorphopsia score patient dme improv follow iva tae regimen one year presenc erm associ metamorphopsia score | D003920;D003930;D019773;D008269;D040262 | T116;T192;T020;T126;T047 |
36,253,498 | siderophor synthesi abil nitrogen fix bacterium nfb gxgl regul transcript level transcript factor trx aminomethyltransferas encod gene amt kosakonia radicincitan gxgl gram negat nitrogen fix nf bacteri strain coat thick capsulatus surfac cell wall becom physic barrier exogen dna enter cell oper genet transform difficult studi optim tn transposon mutagenesi system establish use high osmot ho medium combin electropor transform eventu mutant librari contain total tn insert mutant establish mutant mutant found enhanc capabl synthes siderophor cas agar plate assay spectrophotometr determin bacteri cell two mutant appli cucumb growth promot experi cucumb seedl treat cell signific increas biomass includ seedl height seedl fresh weight root fresh weight root length whole genom sequenc mutant show integr site tn transposon element locat mmyb like helix turn helix transcript regul locus tag trx aminomethyltransferas encod gene locus tag amt genom gxgl respect abil siderophor synthesi target mutant improv tn insert mutagenesi mutant obtain show good plant growth promot effect appli cucumb seedl result suggest identifi function gene regul biosynthesi siderophor azotobact gxgl specif mechan need investig | D018553;D017262 | T168;T123;T002;T109 |
36,253,497 | discoveri small molecul inhibitor effect disrupt iqgap cdc interact breast cancer cell small gtpase cdc integr compon cytoskeleton dysregul lead pathophysiolog condit cancer bind cdc scaffold protein iqgap stabil cdc activ form interact cdc iqgap enhanc migrat invas cancer cell disrupt associ could impair neoplast progress metastasi howev effect mean achiev describ screen compound use homogen time resolv fluoresc base assay identifi small molecul disrupt bind cdc iqgap combin result valid assay counter screen select potent compound cell base experi immunoprecipit cell viabil analysi render four lead compound name ncgc ncgc mls ncgc three inhibit prolifer migrat breast carcinoma cell microscal thermophoresi reveal two compound bind direct cdc one compound reduc amount activ cdc cell effect impair filopodia format dock analysi provid plausibl model compound bind hydrophob pocket adjac gtp bind site cdc conclus identifi small molecul inhibit bind cdc iqgap could potenti yield chemotherapeut agent | D001943 | T191 |
36,253,496 | bama pig manur organ fertil regul watermelon rhizospher bacteri communiti inhibit occurr fusarium wilt continu crop condit fusarium wilt caus fusarium oxysporum f sp niveum import manifest continu crop barrier caus qualiti yield watermelon declin earli stage studi organ fertil ferment bama pig manur appli soil prove signific inhibit occurr diseas improv structur soil microbi communiti howev mechan clear high throughput sequenc technolog combin network picrust function analysi use investig miseq sequenc show bacteri communiti organ fertil treat soil compos phyla genera number genera higher steril water treat soil fertil signific increas divers chang composit bacteri communiti base alpha beta divers anosimadoni analysi lefs speci differ network analysi show fertil improv relat abund bacteria biolog control plant growth promot characterist soil sphingomona halobacillus nocardioid enhanc interact rhizospher bacteria made network structur complex picrust also reveal fertil promot bacteri function metabol genet inform process result show pig manur organ fertil might reduc occurr fusarium wilt regul bacteri communiti interact function metabol watermelon rhizospher soil | D029773;D005670 | T168;T004;T002 |
36,253,495 | suppress renoprotect purin covid patient acut kidney injuri acut kidney injuri aki common patient hospit covid complic clinic cours contribut wors outcom anim studi show adenosin inosin guanosin protect kidney type aki howev evid patient support possibl abnorm low kidney level adenosin inosin guanosin contribut aki address question whether renoprotect purin alter urin covid patient aki purin measur employ ultra high perform liquid chromatographi tandem mass spectrometri stabl isotop label intern standard purin interest compar covid patient without aki n covid patient aki n signific lower urin level adenosin p inosin p guanosin p median reduc respect lower level p median reduc nd messeng b adenosin receptor ie camp moreov covid patient aki urin level aminoguanin endogen inhibitor inosin guanosin metabol near abolish p contrast upstream precursor renoprotect purin name amp gmp signific alter covid patient aki suggest defect convers precursor cd convert amp adenosin gmp guanosin find impli imbal renoprotect purin may contribut aki covid patient pharmacotherapi target restor level renoprotect purin may attenu risk aki suscept patient covid | D058186;D000086382 | T047;T067;T037 |
36,253,493 | factor influenc patient disclosur cancer diagnosi famili dentist onlin survey japan oral care cancer treatment constitut essenti support care aim identifi factor associ cancer patient inform famili dentist cancer diagnosi use generat origin questionnair conduct cross section questionnair studi cancer patient gastric colorect lung breast prostat cancer internet septemb factor influenc patient disclosur cancer diagnosi famili dentist identifi multivari logist regress analysi near half respond inform famili dentist cancer disclos behavior cancer patient distinct associ physician advic odd ratio confid interv ci respond advis inform dentist cancer diagnosi group without physician advic good relationship famili dentist associ disclos behavior studi indic need support cancer patient receiv appropri oral care patient percept physician advic communic famili dentist motiv disclos cancer diagnosi dentist medic worker involv cancer care demonstr benefit medic dental collabor cancer care patient | D030881;D009369 | T055;T191 |
36,253,492 | faecal microbiom wild european badger mele mele comparison wild omnivor mammal across globe investig faecal microbiom wild european badger mele mele use sampl collect post mortem part wale badger found dead studi first publish characteris badger microbiom initi undertook sex match age comparison adult cub microbiom base sequenc v v region rrna gene analysi use qiim pipelin utilis dada silva databas taxonomi assign fusobacteria appear abund microbiom cub adult although signific differ seen alpha beta divers adult cub badger microbiom comparison also made wild omnivor mammal faecal microbiom use public avail data signific differ seen alpha beta divers microbiom differ speci wildlif speci interest diseas bovin tuberculosi knowledg faecal microbiom could assist identif infect badger work suggest comparison made faec btb infect non infect badger age may signific impact microbiom | D064307;D045969;D014380 | T032;T015;T028;T047;T001 |
36,253,491 | million year sulphur isotop record pyrit burial permian triassic despit extens use sulphur isotop ratio understand ancient biogeochem cycl mani studi focus specif time point interest end permian mass extinct epm generat million year permian triassic evap curv staith borehol yorkshir england staith evap record replic major featur global curv confirm new excurs olenekiananisian boundari million year ago incorpor result evap curv sulphur isotop box model model approach reveal three signific pyrit burial event ie pbes triassic particular predict signific biogeochem respons across epm result substanti increas pyrit burial possibl driven siberian trap volcan model suggest million year pyrit burial achiev relat long term stabil latest triassic | D053476;D005580 | T070;T167 |
36,253,489 | strength mass scale law govern mass distribut insid honey bee swarm surviv coloni reproduct bee creat dens cluster thousand suspend individu swarm order magnitud larger size individu maintain mechan stabil hypothes intern structur bulk swarm littl prior inform play key role mechan stabil provid first ever reconstruct posit bee bulk swarm use x ray comput tomographi find mass bee layer decreas distanc attach surfac quantifi distribut bee within swarm vari size made bee find power law govern smallest largest swarm weight support layer scale mass layer formula see text power arrang ensur layer exert fraction total strength averag bee support lower weight maximum grip strength illustr extens scale law relat weight strength singl organ weight distribut within superorgan made thousand individu | D012098 | T081;T040;T079 |
36,253,488 | stack ensembl learn model predict month mortal ischem stroke patient patient acut ischem stroke benefit reperfus therapi nevertheless gray area initi reperfus therapi neither support contraind current practic guidelin situat predict model mortal benefici decis make studi aim develop mortal predict model acut ischem stroke patient receiv reperfus therapi use stack ensembl learn model model use artifici neural network ensembl classifi seven base classifi k nearest neighbor support vector machin extrem gradient boost random forest naiv bay artifici neural network logist regress algorithm clinic data intern stroke trial databas select concis set variabl assess present primari studi outcom caus mortal month stack ensembl model predict month mortal accept perform ischem stroke patient receiv reperfus therapi area curv receiv oper characterist accuraci sensit specif stack ensembl classifi put asid valid set confid interv respect | D000083242 | T047 |
36,253,487 | global distribut soil fauna function group estim litter consumpt across biom soil invertebr ie soil fauna import driver mani key process soil includ soil aggreg format water retent soil organ matter transform mani soil fauna group direct indirect particip litter consumpt howev quantiti litter consum major faunal group across biom remain unknown estim quantiti review observ studi determin biomass soil fauna across various biom observ studi litter consumpt soil fauna compar litter consumpt annual litterfal analyz observ litterfal studi observ litter stock studi biomass faunal group highest temper grassland decreas follow order boreal forest temper forest tropic grassland tundra tropic forest mediterranean ecosystem desert semidesert tropic grassland desert biom mediterranean ecosystem domin termit temper grassland domin omnivor temper forest domin earthworm averag estim litter consumpt relat total litter input rang low desert high temper grassland litter consumpt soil fauna greater grassland forest first studi estim effect differ soil fauna group litter consumpt relat process global scale | D017753;D012987 | T167;T070;T082 |
36,253,486 | target alk cdk tyr kinas cascad sensit ovarian breast tumor parp inhibit via destabil p tefb complex poli adp ribos polymeras parp inhibitor demonstr promis clinic activ multipl cancer howev resist parp inhibitor remain substanti clinic challeng present studi report anaplast lymphoma kinas alk direct phosphoryl cdk tyrosin promot homolog recombin hr repair parp inhibitor resist phospho cdk tyr increas kinas activ nuclear local stabil posit transcript elong factor b activ polymeras ii depend transcript hr repair gene convers alk inhibit increas ubiquitin degrad cdk skp e ligas notabl combin us food drug administr approv alk parp inhibitor mark reduc tumor growth improv surviv mice parp inhibitor platinum resist tumor xenograft model use human tumor biospecimen demonstr phosphoryl alk p alk express associ resist parp inhibitor posit correl p tyr cdk express togeth find support biomark driven combinatori treatment strategi involv alk parp inhibitor induc synthet lethal parp inhibitor platinum resist tumor high p alk p tyr cdk express | D000077548;D000970;D001943;D042863 | T121;T116;T109;T191;T126 |
36,253,484 | phase ii studi talazoparib monotherapi patient wild type brca brca mutat homolog recombin gene talazoparib parp inhibitor activ germlin brca brca gbrca mutant advanc breast cancer activ beyond gbrca poor understood conduct talazoparib beyond brca nct open label phase ii trial evalu talazoparib patient pretreat advanc negat breast cancer n solid tumor n mutat homolog recombin hr pathway gene brca brca patient breast cancer four patient respons evalu criteria solid tumor recist partial respons overal respons rate three addit patient stabl diseas month clinic benefit rate patient germlin mutat palb gpalb encod partner local brca treatment associ tumor regress tumor plasma circul tumor dna ctdna hr defici hrd score correl treatment outcom increas gpalb tumor addit gpalb associ mutat signatur associ tumor respons thus talazoparib demonstr efficaci patient advanc breast cancer gpalb mutat show activ context hr pathway gene mutat beyond gbrca | D000074141;D001943 | T191;T114 |
36,253,480 | anaerob oxid propan coupl nitrat reduct lineag within class symbiobacteriia anaerob microorgan thought play critic role regul flux short chain gaseous alkan scgas includ ethan propan butan terrestri aquat ecosystem atmospher sulfat confirm act electron acceptor support microbi anaerob oxid scgas yet sever energet favour acceptor co exist gase anaerob environ show bioreactor seed biomass wastewat treatment facil perform anaerob propan oxid coupl nitrat reduct dinitrogen gas ammonium bioreactor oper day use c n label experi metagenom metatranscriptom metaproteom metabolit analys character microbi communiti metabol process data collect suggest speci repres novel order within bacteri class symbiobacteriia respons observ nitrat depend propan oxid close genom organ design candidatus alkanivoran nitratireducen encod pathway oxid propan co via fumar addit nitrat reduct key gene express nitrat depend propan oxid result suggest nitrat relev electron sink scga oxid anaerob environ constitut new microbi mediat link carbon nitrogen cycl | D064751;D009566 | T104;T197 |
36,253,475 | nmr lineshap analysi use analyt solut multi state chemic exchang applic kinet host guest system nuclear magnet reson nmr lineshap analysi power tool studi chemic kinet provid techniqu analysi relationship experiment observ spin kinet transit differ environ formula see text correspond chemic kinet transit distinct chemic speci eg free host complex host molecul advantag use analyt solut two three general n state exchang lineshap without j coupl wide use numer calcul nmr spectral fit present sever aspect exchang kinet includ general coalesc condit two state exchang possibl multipl process two state differ equilibrium steadi state mode discuss reduc equival scheme introduc spin kinet contain fast exchang state effect reduc number exchang state theoret result use analyz host guest system contain oxoporphyrinogen complex camphorsulfon acid sever literatur exampl includ isomer protein kinet enzymat reaction theoret treatment experiment exampl present expans systemat approach rigor analys system rich chemic kinet nmr lineshap analysi | D008279;D011506 | T123;T116;T060;T059;T170 |
36,253,471 | popul base match cohort studi earli pregnanc outcom follow covid vaccin sar cov infect data safeti covid vaccin earli pregnanc limit conduct nation popul base match cohort studi assess associ covid vaccin miscarriag prior week gestat separ ectop pregnanc identifi women scotland vaccin week preconcept week day gestat miscarriag n week day gestat ectop n match unvaccin women pre pandem separ pandem period use control show associ vaccin miscarriag adjust odd ratio aor pre pandem control confid interv ci ectop pregnanc aor ci undertook addit analys examin confirm sar cov infect exposur similar found associ miscarriag ectop pregnanc find support current recommend vaccin remain safest way pregnant women protect babi covid | D000022;D000086382;D000086663;D007251;D011271 | T067;T200;T033;T047;T046 |
36,253,468 | shape memori self adapt colloid crystal reconfigur mechan respons crystallin materi central compon mani sens soft robot energi convers storag devic crystallin materi readili deform various stimuli extent recover deform high depend upon bond type inde structur held togeth via simpl electrostat interact minim deform toler contrast structur held togeth molecular bond principl sustain much larger deform easili recov origin configur studi deform properti well facet colloid crystal engin dna crystal larg size greater bodi centr cubic bcc structur high viscoelast volum fraction therefor compress irregular shape wrinkl creas notabl deform crystal upon rehydr assum initi well form crystallin morpholog intern nanoscal order within second crystal compress deform would lead perman irrevers damag substanti structur chang colloid crystal accompani notabl revers optic properti chang exampl wherea origin structur recov crystal exhibit near perfect broadband absorpt ultraviolet visibl region deform crystal exhibit signific increas reflect incid light certain wavelength main increas refract index inhomogen | D003102;D004247 | T123;T122;T114 |
36,253,467 | scalabl platform discov antimicrobi ribosom origin ribosom synthes post translate modifi peptid ripp promis sourc new antimicrobi face rise antibiot resist report scalabl platform combin high throughput bioinformat autom biosynthet gene cluster refactor rapid evalu uncharacter gene cluster proof concept ripp gene cluster origin divers bacteri phyla involv biosynthet gene refactor high throughput manner use biolog foundri success rate heterolog express success refactor gene cluster escherichia coli enabl discoveri compound cover six ripp class lanthipeptid lasso peptid graspetid glycocin linear azol e contain peptid thioamitid subset discov lanthipeptid exhibit antibiot activ one class ii lanthipeptid show low activ klebsiella pneumonia eskap pathogen overal work provid robust platform rapid discov ripp | D003613;D012270 | T125;T121;T026;T109 |
36,253,464 | host adapt mutat hn pandem influenza virus pa gene regul translat effici viral mrnas via grsf avian speci major natur reservoir pandem influenza virus introduc human avian influenza virus gene includ three viral polymeras gene pa pb pb requir host adapt mutat allow viral replic transmiss human previous pa phn viral polymeras found harbor host adapt mutat lead enhanc viral polymeras activ quantifi translat mrna transcript found phn pa associ host adapt mutat led greater translat effici due enhanc cytosol accumul viral mrna depend host rna bind protein grsf mutat grsf bind site viral mrna well grsf knockdown reduc cytosol accumul translat effici viral mrnas studi identifi previous unrecogn mechan host adapt mutat pa regul viral replic host adapt import result provid greater insight host adapt process iav reveal import grsf lifecycl iav | D053118;D016601;D014764;D012324 | T123;T005;T126;T116 |
36,253,460 | fold chang chromatin condens yeast conserv properti mitosi chromatin condens organ mitot chromosom condens critic genom stabil dynam yet degre condens signific differ multicellular singl cell eukaryot less clear whether minimum degre chromosom condens unicellular eukaryot exploit two photon microscopi analyz chromatin condens live fix cell enabl studi organ readili amen genet modif includ yeast saccharomyc cerevisia schizosaccharomyc pomb kluyveromyc lacti candida albican well protist trypanosoma brucei found mitot chromosom rang speci condens fold relat interphas chromatin addit use two photon microscopi reveal chromatin reorgan interphas human hepatoma cell infect hepat c virus decondens compar uninfect cell correl previous report viral induc chang chromatin dynam work demonstr power two photon microscopi analyz chromatin broad rang cell type condit includ non model singl cell eukaryot suggest similar condens level evolutionarili conserv properti unicellular eukaryot import proper chromosom segreg furthermor provid new insight process chromatin condens mitosi unicellular organ well respons human cell viral infect | D002843;D012568 | T004;T116 |
36,253,456 | effect rhizophagus intraradic soybean yield composit microbi communiti rhizospher soil continu crop soybean soybean glycin max l import oil econom crop world howev soybean continu crop may lead declin soybean yield qualiti purpos studi investig effect rhizophagus intraradic soybean growthyield root rot diseas index composit microbi communiti rhizospher soil continu crop soybean r stage result show seed weight seed yield per plant yield per hectar pod per plant seed number per plant branch number plant height fresh weight root shoot diseas index soybean root rot signific affect inocul r intraradic soybean continu crop growthyield index soybean highest inocul soybean plant non continu crop inocul r intraradic soybean continu crop signific decreas increas diseas index soybean root rot respect bacteri divers level rhizospher soil continu crop soybean lower non continu crop soybean furthermor also show inocul r intraradic could increas bacteri fungal divers rhizospher soil soybean also show inocul soybean continu crop effect composit microbi communiti rhizospher soil soybean proteobacteria ascomycota domin bacteri fungal phylum sampl respect result would contribut evalu biocontrol potenti r intraradic soybean root rot diseas increas soybean yield improv composit microbi communiti rhizospher soil continu crop soybean | D064307;D058441 | T001;T032;T070;T028 |
36,253,454 | splitsmlm spectral demix method high precis multi color local microscopi appli nuclear pore complex singl molecul local microscopi smlm dichroic imag splitter provid invalu multi color inform regard coloc individu molecul often suffer technic limit classic demix algorithm tend give suboptim result term local precis correct chromat error present imag splitter base multi color smlm method splitsmlm offer much improv local precis drift correct compens chromat distort optim perform fluorophor specif buffer equal reactiv rate simultan imag novel spectral demix algorithm splitvisu fulli preserv local precis essenti data loss correct chromat error nanomet scale multi color perform improv use optim fluorophor filter combin appli three color imag nuclear pore complex npc method provid refin posit individu npc protein reveal pom cluster act npc deposit loci henc illustr strength general applic method | D008853;D022022 | T026;T059 |
36,253,452 | associ suicid relat behavior prefront dysfunct emot cognit person trait mood disord suicid serious public health problem urgent identifi biomark associ suicid prevent aim clarifi associ across suicid behavior person trait brain activ emot stimul task use near infrar spectroscopi nir patient mood disord mood disord patient histori suicid attempt mdsa mood disord patient histori suicid attempt mdnsa healthi individu studi mdsa patient show signific high impuls hopeless compar healthi subject great respons thread word task orbitofront cortex ofc dorsolater prefront cortex dlpfc compar mdnsa patient signific correl person trait brain activ mdnsa show trend result suggest person trait activ ofc dlpfc negat emot cognit stimuli associ suicid behavior indic find involv pathophysiolog suicid mood disord | D019964;D059020 | T033;T048 |
36,253,448 | efficaci safeti pre gastroscopi commerci carbohydr rich whey protein beverag vs plain water randomis control trial clinic benefit safeti carbohydr load pre gastroscopi remain unclear aim determin effect commerci carbohydr rich whey protein beverag versus plain water given pre gastroscopi gastric residu volum well determin advers event singl centr singl blind parallel group sex stratifi random control trial particip random either carbohydr rich whey protein beverag group resourc nestl health scienc control group ml plain water given pre gastroscopi gastric content aspir suction reservoir bottl determin gastric residu volum grv visual analogu scale vas well anxieti hunger thirst tired weak compar intervent advers event also evalu post intervent screen particip male mean age year random compar control group carbohydr beverag associ signific higher grv p anxieti less intervent carbohydr beverag p adjust confound fewer particip also experienc hunger p thirst p serious advers event report intervent commerci carbohydr rich whey protein beverag associ higher gastric residu volum better well safetri registr clinicaltrialgov identifi nct date registr | D005773;D014867 | T060;T121;T197;T061 |
36,253,444 | ecolog sensit vulner fish fleet land climat chang across region degre exposur fish communiti environment chang partial determin vulner target speci land composit henc identifi speci ecolog contribut vulner land key step evalu risk pose climat chang analys tempor variabl intrins sensit ecolog vulner portugues fisheri land consid speci proport deriv weight revenu account diversif speci fleet explor speci depend fisheri combin vulner analys carri separ three fleet typolog three region opposit observ global scale ecolog sensit fisheri land display declin across area fish fleet consid fleet independ trawl averag vulner lower fleet sensit land increas sinc hand high vulner found multi gear fleet compens diversif speci caught purs sein fleet target low vulner speci present high fisheri depend speci result highlight import combin inform ecolog vulner diversif fish resourc region scale provid measur ecolog exposur climat chang | D057231;D000090262 | T056;T070 |
36,253,438 | facil synthesi chitosan g pvpf mwcnts applic cu ii ion remov bacteri growth inhibit aqueous solut herein studi chitosan graft vinylpyridin cs g pvp two polymer hybrid cs g pvpf mwcnts ii wt wt f mwcnts respect prepar character use adsorb remov cu ii ion aqueous solut batch process obtain cs g pvp character use fourier transform infrar spectroscopi ft ir identifi surfac function group addit thermal gravimetr analysi tga scan electron microscopi sem perform assess thermal stabil morpholog element analysi obtain cs g pvp cs g pvpf mwcnts ii energi dispers x ray edx map analysi obtain cs g pvpcu cs g pvpf mwcntscu sampl confirm perform adsorpt batch process applic langmuir adsorpt isotherm evalu better understand adsorpt process addit antibacteri activ cs g pvp two polymer hybrid cs g pvpf mwcnts ii evalu three gram bacteria staphylococcus aurous bacillus subtitl streptococcus faecali three gram bacteria escherichia coli pseudomona aeruginosa neisseria gonorrhoea result show effici cs g pvp copolym improv inclus f mwcnts substrat toward adsorpt cu ii ion antibacteri activ well | D048271;D014874 | T121;T131;T109 |
36,253,437 | obes relat biomark underli share genet architectur childhood bodi mass index childhood asthma obes asthma common diseas high popul burden worldwid recent genet associ studi shown obes associ asthma adult relationship childhood obes childhood asthma under mechan link obes asthma remain clarifi present studi leverag larg scale genet data uk biobank sever data sourc investig share genet compon bodi mass index bmi n children childhood asthma n case n control includ gwas summari statist nine obes relat biomark evalu potenti biolog mediat under obes asthma found genet correl rg p childhood bmi childhood asthma wherea genet correl adult bmi n childhood asthma null rg p genom structur equat model analysi provid evid genet effect childhood bmi childhood asthma standard effect size p driven genet compon adult bmi bayesian coloc analysi identifi share causal variant rs map gene amn use gene express data lung tissu mendelian random show odd ratio childhood asthma one standard deviat higher childhood bmi confid interv systemat survey obes relat biomark show il adiponectin potenti biolog mediat link obes asthma children larg scale genet studi provid evid uniqu childhood obes pathway could lead childhood asthma find shed light childhood asthma pathogen mechan prevent | D001249;D063766 | T033;T047 |
36,253,436 | identif cuproptosi relat subtyp develop prognost signatur colorect cancer cuproptosi novel form copper mediat regul cell death particip tumor progress howev role cuproptosi relat gene crgs colorect cancer crc remain unclear aim investig cuproptosi subtyp build predict model improv prognosi patient crc gene express data download tcga databas identifi distinct molecular subtyp use non negat matrix factor algorithm robust effici prognost signatur construct perform multivari cox regress analysi valid use gene express omnibus cohort base gene express matrix crc abund infiltr immun cell tumour microenviron score calcul use cibersort estim algorithm respect prrophet algorithm use predict sensit patient differ chemotherapi drug two distinct molecular subtyp identifi base crgs subtyp c character advanc clinic stage wors overal surviv prognost signatur construct base deg two cuproptosi subtyp predict abil valid extern databas patient crc belong low risk group signific higher surviv rate belong high risk group addit remain valid prognost indic strata age sex tumor locat tnm stage signific persist multivari cox regress analysi analyz prognost signatur higher immun score observ low risk group present better prognosi aktinhibitorviii doxorubicin lenalidomid tipiparnib sensit high risk score group high accur nomogram construct improv clinic applic risk score compar ideal nomogram model consist clinicopatholog featur perform well predict patient surviv conclus studi provid new way perspect predict prognosi patient crc guid effect treatment regimen | D015179;D003300 | T121;T123;T196;T191 |
36,253,435 | buscophylo webserv busco base phylogenom analysi non specialist present buscophylo tool enabl student establish scientist easili perform busco base phylogenom analysi start set genom sequenc buscophylo effici user friend web server freeli access https buscophyloinraorgma sourc code along document freeli avail mit licens https githubcomalaesahboubuscophylo | D016678;D012984 | T090;T170;T073;T028 |
36,253,434 | evid intervent associ dna methyl chang monocyt patient posttraumat stress disord dna methyl pattern respons environment influenc observ spark interest potenti psycholog intervent influenc epigenet process recent studi observ correl dna methyl chang therapi outcom howev control chang cell composit studi two aim first sought replic therapi associ chang dna methyl common assess candid gene isol monocyt femal patient post traumat stress disord ptsd second exploratori goal identifi novel genom region substanti pre post intervent dna methyl chang perform whole genom bisulfit sequenc wgbs two patient ptsd equival test bayesian analys provid evid physiolog meaning intervent associ dna methyl chang monocyt ptsd patient common investig target gene nrc fkbp slca oxtr furthermor wgbs yield limit set candid region suggest evid differenti dna methyl pre post therapi differenti dna methyl pattern prove replic investig entir cohort conclud evid major recurr intervent associ dna methyl chang investig gene monocyt patient ptsd | D019175;D013313 | T044;T048 |
36,253,431 | differenti human induc pluripot stem cell hypothalam vasopressin neuron minim exogen signal partial convers naiv state famili neurohypophys diabet insipidus fndi degen diseas vasopressin avp neuron studi mous vivo model indic accumul mutant avp prehormon associ fndi patholog howev studi human fndi patholog vivo technic challeng therefor vitro human model need develop exogen signal minim earli phase differenti vitro mous embryon stem cell esc induc pluripot stem cell ipsc differenti avp neuron wherea human escsipsc die human escsipsc general similar mous epiblast stem cell mepisc compar mous esc studi convert human fndi specif ipsc naiv convers kit although convers partial found improv cell surviv minim exogen signal differenti rostral hypothalam organoid overal method provid simpl straightforward differenti direct may improv effici hypothalam differenti | D020790;D057026 | T047;T025 |
36,253,430 | lightweight convolut neural network model recept field block c shape root canal detect mandibular second molar rapid accur detect c shape root canal mandibular second molar assist dentist diagnosi treatment oral panoram radiographi one effect method determin root canal teeth alreadi tradit method base deep learn learn characterist c shape root canal tooth imag howev previous studi shown accuraci detect c shape root canal still need improv suitabl implement network structur limit hardwar resourc paper new lightweight convolut neural network design combin recept field block rfb optim featur extract order optim hardwar resourc requir model lightweight multi branch convolut neural network model develop studi improv featur extract abil model c shape root canal tooth imag rfb merg model rfb achiev excel result target detect classif multiscal recept field block small convolut kernel use replac larg convolut kernel allow model extract detail featur reduc comput complex final accuraci area receiv oper characterist curv auc valu c shape root canal imag data mandibular second molar respect result show deep learn model propos paper accur lower comput complex mani similar studi addit score weight class activ map score cam generat local intern structur contribut predict | D003786;D014092 | T023;T030 |
36,253,428 | screen sigpcr librari combin cisplatin lung cancer screen sirna target human g protein coupl receptor gpcrs multiplex combin cisplatin lung cancer cell cell viabil measur hard captur anticanc effect sigpcr direct cell count reveal anticanc potenti divers gpcrs hit twofold growth inhibit p valu combin treatment cisplatin sirna five gene adraa frl npsr npi tacr enhanc anti prolifer efficaci cancer cell reduc self recoveri abil surviv cell remov combin treatment target valid confirm knockdown tacr express exhibit anticanc efficaci singl combin treatment cisplatin q omic http qomicsio analysi show high express tacr unfavor patient surviv particular mutat gpcr signal pathway present screen data provid use resourc gpcr target biomark improv efficaci cisplatin treatment | D000970;D002289;D008175 | T121;T191;T109 |
36,253,427 | enhanc cholesterol biosynthesi promot breast cancer metastasi via modul ccdc express neutrophil extracellular trap format neutrophil extracellular trap net demonstr regul metastasi breast cancer studi show de novo cholesterol biosynthesi induc aspp deplet mous breast cancer cell human breast cancer cell mda mb promot net format vitro well lung metastas mice intraven inject aspp defici cell simvastatin berberin bbr cholesterol synthesi inhibitor effici block aspp deplet induc net format cholesterol biosynthesi great enhanc coil coil domain contain protein ccdc express cancer cell well lung metastas ccdc express co local caveolin lipid raft molecul damp inhibitor lipid raft format data suggest cholesterol biosynthesi promot ccdc express lipid raft depend manner clinic express ccdc posit correl express hydroxi methylglutaryl coareductas hmrcg citrullin histon h hcit tissu breast cancer patient high express ccdc hmgcr relat wors prognosi breast cancer patient conclus studi explor novel mechan de novo cholesterol biosynthesi regul ccdc express net format breast cancer metastasi target cholesterol biosynthesi may promis therapeut strategi treat breast cancer metastasi | D001943;D002784;D065206;D008175;D008565 | T026;T121;T123;T116;T109;T192;T191 |
36,253,426 | movement relat artefact mr art dataset match motion corrupt clean structur mri brain scan magnet reson imag mri provid uniqu opportun investig neural chang healthi clinic condit larg inher suscept motion howev often confound measur approach assess correct prevent motion corrupt mri measur activ develop effort great benefit care control dataset present uniqu dataset structur brain mri imag collect healthi adult includ motion free motion affect data acquir particip match dataset allow direct evalu motion artefact impact deriv data test approach correct dataset stand contain imag differ level motion artefact particip enrich expert score character imag qualiti clinic point view also complement standard imag qualiti metric obtain mriqc goal dataset rais awar issu provid use resourc assess improv current motion correct approach | D016477;D008279 | T060;T068;T170;T059 |
36,253,425 | great plain dust bowl drought spread heat extrem around northern hemispher extraordinari heat extrem occur area northern hemispher far record set heat us associ great plain dust bowl drought climat model sensit experi use identifi new mechan involv warm season circumglob atmospher teleconnect pattern spread heat extrem far flung area northern hemispher aris intens heat desicc great plain twenti first centuri human popul region northern hemispher experienc heat extrem compar demonstr human influenc northern hemispher temperatur heat extrem disastr unpreced region land use practic great plain point possibl futur intens region drought could affect heat extrem hemispher scale | D055864;D006358 | T070 |
36,253,422 | fault diagnosi method bear util glcm mbasa base kelm studi fault diagnosi method bear util gray level co occurr matrix glcm multi beetl antenna search algorithm mbasa base kernel extrem learn machin kelm present propos method featur extract time frequenc imag base glcm propos extract featur bear vibrat signal multi beetl antenna search algorithm base kelm mbasa kelm present recogn state bear kelm employ kernel base framework better general tradit extrem learn machin necessari look excel optim algorithm select appropri regular paramet kernel paramet kelm model paramet kelm model affect perform tradit beetl antenna search algorithm employ one beetl difficult find optim paramet rang paramet optim wide multi beetl antenna search algorithm mbasa employ multi beetl present select regular paramet kernel paramet kelm experiment result demonstr mbasa kelm stronger fault diagnosi abil bear lssvm knn | D001517;D000069550 | T066;T204 |
36,253,421 | effect putrescin space use activ sea lamprey petromyzon marinus fish use odor avoid exposur predat diseas har odor repel prove use manag initi conserv nativ speci control invas popul evalu behavior respons invas sea lamprey putrescin decay molecul mani prey organ avoid putrescin found tissu extract contain sea lamprey alarm cue human saliva two mixtur known elicit flight avoid respons migratori sea lamprey use two behavior assay evalu metric repel behavior prefer space use chang activ rate found context depend result smaller assay individu fish found putrescin effect sea lamprey activ induc avoid larger assay multipl anim sea lamprey avoid putrescin result also show consist chang activ avoid behavior sea lamprey expos alarm cue smaller assay conclud design could prove use high throughput screen tool also investig novel odor identifi sea lamprey skin petromyzonacil found behavior effect odor synergi putrescin result show limit evid putrescin act robust repel sea lamprey highlight import environment context interpret avoid behavior laboratori set | D048428 | T013 |
36,253,420 | wearabl soft robot allevi pain fear wearer social soft robot may provid new solut allevi human pain fear introduc hand held soft robot clench wearer robot compris small airbag inflat provid wearer feel clench conduct depth studi adult particip pain research protocol use thermal stimul investig effect wear robot pain percept fear inject pain assess scale score perceiv pain decreas signific formula see text particip wore robot compar baselin condit robot worn addit saliva test result show downward trend oxytocin level robot provid wearer haptic feedback via inflat intern airbag respons wearer clench furthermor negat psycholog state particip measur use posit negat affect scale improv signific wear robot also reveal salivari cortisol level indic stress decreas signific across particip end experi addit particip fear inject signific improv particip experi result suggest wearabl soft robot may allevi human percept pain fear medic treatment vaccin | D012371;D000076251 | T090;T073 |
36,253,419 | cryo em structur transloc binari toxin complex cdta bound cdtb pore clostridioid difficil bacteria express binari toxin transloc system consist enzymat subunit transloc pore deliv enzym host cell endocytosi clinic import bacterium system clostridioid difficil former clostridium cdta cdtb protein system repres import therapeut target cdtb propos di heptam physiolog heptamer structur yet report report cryo em structur cdta bound cdtb pore reveal cdta bind induc partial unfold tilt first cdta helix cdtb pore nss loop exist conform suggest involv substrat transloc final variabl analysi reveal cdta movement fold unfold state dynam structur inform provid insight drug design hypervirul c difficil strain | D016360 | T007 |
36,253,418 | subcutan implant electromagnet biosensor system continu glucos monitor continu glucos monitor system cgms becom increas popular diabet manag compar convent method self blood glucos monitor system help understand physiolog respons toward nutrit intak physic activ everyday life glucos control cgms avail market two type base work principl needl type system week lifespan eg enzym base freestyl libr implant type system eg fluoresc base senseon month lifespan commerci avail altern work method herein propos electromagnet base sensor subcutan implant capabl track minut chang dielectr permitt owe chang blood glucos level bgl proof concept propos electromagnet base implant sensor valid intraven glucos toler test ivgtt conduct swine beagl control environ sensor interfac modul mobil applic glucos map algorithm also develop continu measur freeli move beagl oral glucos toler test ogtt result short term h ivgtt long term h ogtt test summar work close trend observ sensor frequenc bgl gtt experi anim speci | D015374;D015190 | T060;T059;T075 |
36,253,417 | sirtuin protect colorect cancer dna damag keep nucleotid avail previous studi report sirtuin sirt member nad depend class iii histon deacetylas famili high express colorect cancer crc herein show sirt knockdown impair product ribos phosphat essenti nucleotid synthesi result continu irrepar dna damag consequ lead cell cycl arrest enhanc apoptosi crc cell sirt silenc induc effect revers nucleosid supplement mechanist sirt activ transketolas tkt key enzym non oxid pentos phosphat pathway demalonyl depend manner furthermor tkt essenti sirt induc malign phenotyp crc vivo vitro altogeth sirt silenc induc dna damag crc via post translat modif inhibit tumor growth suggest sirt serv promis target crc treatment | D015179;D004249;D037761 | T049;T191;T126;T116 |
36,253,416 | mathemat model reveal potenti acceler supercontin cycl supercontin cycl focus research mani year paramet cyclic remain central debat thus predict occurr next supercontin remain elus research mathemat point view adopt base assumpt supercontin columbia assembl myr formula see text supercontin rodinia assembl myr formula see text younger supercontin calcul follow mathemat equat formula see text formula see text repres assembl n posit supercontin sequenc therefor gondwana formula see text amalgam myr pangea formula see text myr eurasia formula see text myr pangea proxima formula see text might form myr moreov two logarithm regress give fair similar result confirm constant acceler supercontin cycl probabl detrit zircon metamorph hafnium isotop record support assembl hypothes produc mathemat equat howev recent supercontin megacontin call eurasia lack strong geolog evid three dataset find might reconcil paradox brought closer age time earth recent supercontinent assembl assum constant cyclic cycl | D006195;D008962 | T062;T196;T170 |
36,253,414 | character composit ipsc deriv cell bulk transcriptom data cellmap induc pluripot stem cell ipsc deriv cell type increas employ vitro model system drug discoveri studi meaning import understand reproduc ipsc deriv cultur similar equival endogen cell type singl cell singl nucleus rna sequenc rna seq use gain understand expens time consum bulk rna seq data generat quicker lower cost silico cell type decomposit effici inexpens conveni altern leverag bulk rna seq deriv fine grain inform cultur develop cellmap comput tool deriv cell type profil public avail singl cell singl nucleus dataset infer cell type bulk rna seq data ipsc deriv cell line | D057026 | T025 |
36,253,413 | facet effect hematit hydrolysi phthalat ester ambient humid condit phthalat ester pae extens use addit plastic wallcov caus sever environment contamin increas public health concern find hematit nanoparticl specif facet control effici catalyz pae hydrolysi ambient humid condit hydrolysi rate order magnitud higher water satur condit catalyt perform hematit show signific facet depend reactiv order relat atom array surfac undercoordin fe facet proper neighbor fe fe distanc nm bident coordin pae thus induc much stronger lewi acid catalysi studi may inspir develop nanomateri appropri surfac atom array improv understand natur transform pae low humid environ provid promis approach remediatepurifi ambient air contamin pae | D004952;D010795 | T109 |
36,253,412 | ration consider akkermansia muciniphila target intestin health advantag challeng one promis next generat probiot ngps akkermansia muciniphila well known mucin degrad bacterium proven close relat metabol diseas human host howev role muciniphila host intestin health remain ambigu comprehens summar discuss characterist distribut colon muciniphila human gastrointestin tract git propos applic muciniphila biomark longev diagnost prognost intestin diseas intestin health cautious consid precis dietari regul mediat treatment intestin diseas alter abund muciniphila although benefici role muciniphila compon intestin inflamm discov gnotobiot mice specif gut microbiota certain genotyp colorect cancer anim model infect specif pathogen muciniphila may relat occurr develop intestin diseas genom analysi emphas strain level phylogenet differ muciniphila indic clear descript discuss strain critic practic applic review provid much need insight precis applic muciniphila | D009077;D061327 | T123;T007;T116 |
36,253,411 | analysi spatial tempor impact differ birth rate mainland china continu declin birth rate led seri problem disproport popul structur sever age popul restrict countri econom develop deeper understand geograph differ influenc factor birth rate paper collect organ birth popul data provinc mainland china nation region divid seven natur geograph region obtain spatial hierarchi hierarch bayesian spatio tempor model establish inla algorithm estim model paramet result show signific spatial tempor differ birth rate mainland china reflect main combin spatial tempor spatio tempor interact effect spatial dimens northeast low northwest southwest high birth rate upward trend east west trend caus unbalanc econom develop differ fertil attitud differ fertil secur reflect region differ spatial effect china birth rate show overal downward trend time dimens howev region except northeast saw signific temporari increas birth rate reflect tempor effect differ birth rate | D001723;D005298 | T071;T032;T055;T040;T062;T081 |
36,253,409 | reconstruct ovin axon cytoarchitectur enabl accur model brain biomechan increas need focus understand local brain microstructur affect transport drug molecul direct administ brain tissu exampl convect enhanc deliveri procedur studi report systemat attempt character cytoarchitectur commissur long associ project fibr name corpus callosum fornix corona radiata specif aim map differ region tissu provid essenti inform develop accur model brain biomechan ovin sampl imag use scan electron microscopi combin focus ion beam mill generat volum reconstruct tissu subcellular spatial resolut focus place characterist cytolog featur white matter axon align tissu tract reconstruct relat larg volum includ signific number axon perform outer axon ellipt outer axon cross section area relat perimet measur studi well resolv microstructur featur provid use insight fibrous organ tissu whose micromechan behaviour composit materi present ellipt tortuous tubular axon structur embed extra cellular matrix drug flow captur microstructur base model use volum either reconstruct direct imag generat silico use paramet extract databas imag lead workflow enabl physic accur simul drug deliveri target tissu | D001921;D066127 | T023;T024 |
36,253,408 | csf gap biomark synapt dysfunct associ tau patholog alzheim diseas test whether cerebrospin fluid csf growth associ protein gap concentr elev alzheim diseas ad dementia associ hallmark ad examin csf gap measur particip cognit normal cn individu mild cognit impair mci individu ad dementia alzheim diseas neuroimag initi adni studi associ investig csf gap clinic diagnosi atauneurodegener n status csf blood biomark ad cognit measur brain neuroimag find csf gap level increas patient ad dementia mean pgml compar cn mean pgml mci mean pgml p group csf gap correl csf phosphoryl tau p tau r p high diagnost accuraci differenti tau posit status vs tau negat status area receiv oper characterist curv csf gap particular elev among individu tau posit status high csf gap associ longitudin deterior cognit score brain neuroimag find csf gap associ clinic diagnosi ad dementia individu tau status cognit measur find neuroimag studi impli csf gap biomark synapt dysfunct could predict diseas progress ad patient | D000544;D060825 | T047;T048 |
36,253,406 | intrins tempor order c jun n termin phosphoryl regul activ orchestr co factor recruit protein phosphoryl major regulatori mechan cellular signal c jun proto oncoprotein phosphoryl four residu within transactiv domain tad jnk famili kinas function signific c jun multisit phosphoryl remain elus show c jun phosphoryl jnk exhibit defin tempor kinet serin serin phosphoryl rapid threonin threonin identifi posit phosphoryl site relat kinas dock motif primari sequenc main factor control phosphoryl kinet function analysi reveal three c jun phosphoryl state unphosphoryl c jun recruit mbd repressor serin doubli phosphoryl c jun bind tcf co activ wherea fulli phosphoryl form disfavour tcf bind attenu jnk signal thus c jun phosphoryl encod multipl function state drive complex signal respons singl jnk input | D048031;D016755 | T123;T126;T116 |
36,253,404 | new human inspir metaheurist algorithm solv optim problem base mimick sew train paper introduc new human base metaheurist algorithm call sew train base optim stbo applic handl optim task fundament inspir stbo teach process sew beginn tailor theori propos stbo approach describ mathemat model three phase train ii imit instructor skill iii practic stbo perform evalu fifti two benchmark function consist unimod high dimension multimod fix dimension multimod cec test suit optim result show stbo high power explor exploit provid suitabl solut benchmark function perform stbo compar eleven well known metaheurist algorithm simul result show stbo high abil balanc explor exploit provid far competit perform solv benchmark function competitor algorithm final implement stbo solv four engin design problem demonstr capabl propos stbo deal real world applic | D000465;D011340 | T170;T041 |
36,253,401 | angiotensin ii type receptor associ protein interact transferrin receptor promot intern kidney fibrosi common pathway lead chronic kidney diseas angiotensin ii type receptor atr associ protein atrap origin identifi atr bind protein previous report system knockout atrap exacerb kidney fibrosi age mice although effect atrap appear atr independ action molecular mechan remain poor understood elucid molecular mechan atrap independ atr explor novel atrap interact protein mass spectrometr analysi immunoprecipit flag tag atrap complex reveal candid protein potenti interact atrap gene ontolog analysi reveal protein relat vesicl traffick membran transport mani membran protein includ transferrin receptor tfr enrich tfr promot cellular iron uptak iron key factor involv kidney fibrosi focus tfr confirm interact atrap addit find reveal enhanc atrap express decreas cell surfac tfr express without alter overal cellular tfr express level furthermor enhanc atrap express attenu cellular iron level togeth result highlight role atrap suppressor tfr function facilit tfr intern affect iron metabol oxid stress signal | D048868;D000804;D011990 | T123;T121;T116;T192 |
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