PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,252,993 | benefit support group patient live implant cardiovert defibril mix method systemat review meta analysi patient implant cardiovert defibril icd experi anxieti depress reduc qualiti life qol | D017147 | T074 |
36,252,992 | cardiac care children dystrophinopathi femal carri dmd gene variat provid succinct evid base andor consensus base best practic guidanc cardiac care children live duchenn muscular dystrophi dmd well recommend screen manag femal carrier mutat dmd gene | D009202;D020388 | T047 |
36,252,991 | factor affect nurs health technician student satisfact distanc learn covid pandem morocco survey base observ studi distanc learn describ learn base use new multimedia technolog internet allow student acquir new knowledg skill distanc studi aim deter mine satisfact level distanc learn associ factor among nurs health technician student coronavirus diseas pandem morocco | D000086382;D020375;D013338 | T065;T047;T097;T067 |
36,252,990 | equal z standard set method estim minimum number panelist medic school object structur clinic examin taiwan simul studi undertak standard set exercis common method set passfail cut score high stake examin recent introduc equal z standard set method ez method found valid effect altern common use angoff hofste method variant current studi aim estim minimum number panelist requir obtain accept reliabl cut score use ez method | D002983;D004521 | T065;T080 |
36,252,983 | post acut health care burden sar cov infect retrospect cohort studi post acut burden health care use sar cov infect unknown sought quantifi post acut burden health care use sar cov infect among communiti dwell adult ontario compar posit negat polymeras chain reaction pcr test result sar cov infect | D000086382 | T047;T067 |
36,252,977 | pattern etiolog earli childhood epilepsi experi tertiari care univers center investig seizur characterist type defin etiolog epilepsi children age year use ila classif | D004831;D004827;D004829 | T033;T047 |
36,252,976 | elev level creatin phosphokinas newborn clinic signific associ congenit muscl diseas establish normal creatin phosphokinas cpk rang newborn mode deliveri prove high cpk level neonat specif indic muscular patholog | D002585;D003402;D009135 | T061;T116;T126;T079;T047 |
36,252,975 | preval associ factor alexithymia among medic student cross section studi saudi arabia assess preval alexithymia associ factor among medic student king saud univers ksu riyadh kingdom saudi arabia | D013337 | T097 |
36,252,974 | manag lennox gastaut syndrom deep brain stimul systemat literatur review review current literatur regard efficaci safeti deep brain stimul dbs lennox gastaut syndrom lgs | D046690;D020646;D065768 | T061;T023;T047 |
36,252,972 | review electroencephalographi signal approach mental stress assess innov electroencephalographi eeg centuri ago support techniqu assess brain structur function clinic health research applic eeg signal identifi frequenc rang delta hz theta hz alpha hz beta hz gamma hz stress sens emot tension caus sever life event exampl worri someth pressur face signific challeng caus stress human bodi affect stress various way promot inflamm affect cardiac health autonom nervous system activ mental stress posttraumat stress disord alzheim diseas common brain stress disord sever method use previous identifi stress instanc magnet reson imag singl photon emiss comput tomographi eeg eeg identifi electr activ human brain appli small electrod posit scalp brain use non invas method collect feedback stress hormon addit serv reliabl tool measur stress furthermor evalu human stress real time complic challeng review demonstr power frequenc band mental stress behavior frequenc band base medic research experienceband base medic research experi | D000544;D004569 | T060;T047;T034;T048 |
36,252,970 | evalu cognit dysfunct clock draw test multipl sclerosi clinic isol syndrom patient correl neuropsycholog test evalu cognit status simpl practic test clock draw test cdt larger multipl sclerosi ms patient group comparison control | D003072;D060825;D009103;D020529 | T047;T048 |
36,252,969 | ischem stroke patient fahr diseas carri biallel mutat myorg gene fahr diseas fd neurodegen disord character symmetr calcif bilater basal ganglia dentat nuclei mutat six gene known caus fd present case year old woman admit bradykinesia start develop year ago brain ct mri reveal sever calcif bilater basal ganglia thalamus dentat nuclei subcort white matter whole exom sequenc reveal two previous describ compound heterozyg mutat within myorg gene one year later patient develop sudden onset left side hemiparesi mri reveal small infarct right intern capsul therefor present case find expand clinic spectrum fd import associ ischem stroke fd need studi | D001480;D000083242;D019636 | T047 |
36,252,968 | associ intron vntr polymorph nos gene rapid cycl treatment resist bipolar disord case control studi evalu relationship patient clinic paramet especi clinic specifi intron vntr variant endotheli nitric oxid synthas nos gene bipolar disord bd patient | D001714;D011110 | T045;T048 |
36,252,967 | epilepsi awar among rabigh provinc resid saudi arabia cross section survey studi investig knowledg attitud toward epilepsi rabigh provinc western saudi arabia | D001364;D004827 | T033;T047;T041 |
36,252,966 | kcnma relat refractori status epilepticus respond vagal nerv stimul case report literatur review epilepsi one preval chronic neurolog diseas caus sever morbid well mortal mutat kcnma gene result rare genet diseas caus epilepsi core present neurolog non neurolog manifest report patient kcnma gene mutat report kcnma gene variant refer cc p proleu encod subunit alpha calcium sensit potassium channel caus epilepsi dyskinesia young saudi femal daughter consanguin parent case show calcium sensit potassium channel caus isol general epilepsi report previous singl case moreov case aid delin clinic structur pictur treatment kcnma gene mutat patient | D004827;D013226;D055536 | T033;T047;T061 |
36,252,965 | outcom characterist myasthenia gravi year retrospect cross section studi king fahad medic citi investig distribut muscl weak myasthenia gravi mg therapeut respons categori | D009157;D011950 | T047;T116;T192 |
36,252,955 | organocatalyt asymmetr approach function cyano styrylcoumarin via bifunct catalysi novel organocatalyt reaction cascad cyano styrylcoumarin mercaptoacetophenon describ base stereocontrol function cyanocoumarin proceed sequenc thia michaelaldolannul reaction high diastereo enantioselect reaction realiz employ enantioselect bifunct catalysi exhibit broad substrat scope excel function group toler synthet applic involv transform imidoest group thus open access biolog relev coumarin lacton fuse product | D007783 | T109 |
36,252,951 | sialidas inhibitor differ mechan sialidas neuraminidas enzym catalyz hydrolysi sialic acid sia contain molecul most remov termin sia desialyl desialyl sialidas modul function target compound thus often involv biolog pathway inhibit sialidas inhibitor import approach understand sialidas function under mechan could serv therapeut approach well transit state analogu anti influenza drug oseltamivir zanamivir major sialidas inhibitor addit difluoro sialic acid develop mechan base sialidas inhibitor fluorin quinon methid base suicid substrat report sialidas product analogu inhibitor also explor final natur product shown competit inhibiton viral bacteri human sialidas perspect describ sialidas inhibitor differ mechan activ futur potenti includ transit state analogu inhibitor mechan base inhibitor suicid substrat inhibitor product analogu inhibitor natur product inhibitor | D009439;D001688 | T123;T121;T126;T116 |
36,252,946 | auditori comprehens intervent peopl aphasia scope review scope review examin studi report restor treatment design improv auditori comprehens peopl aphasia | D032882;D001037 | T047;T048;T041;T080 |
36,252,902 | short term exposur norethisteron affect swim behavior antioxid enzym activ medaka larva led masculin adult popul norethisteron net one synthet progestin detect increas frequenc water environ distribut ocean potenti toxic risk marin organ howev current studi advers effect progestin includ net aquat environ focus freshwat organ main fish present marin medaka oryzia melastigma larva expos ngl net day swim behavior oxid antioxid relat enzym activ sex thyroid hormon level gene transcript pattern larva measur net treatment medaka larva rais artifici seawat month age sex ratio count ten day exposur ngl net inhibit swim behavior marin medaka larva show time rest state signific prolong time larg motor state signific reduc disrupt oxid antioxid system signific regul enzymat activ reactiv oxygen speci ros malondialdehyd mda glutathion peroxidas gsh px affect hormon level larva lower keto testosteron kt triiodothyronin concentr rna seq result show ngl net exposur day chang transcript level gene regul regul differenti express gene deg main signific enrich piwi interact rna pirna gonad develop gametogenesi steroidogenesi biolog process etc remov net exposur return breed day signific increas male proport observ sexual matur medaka popul net treat group result show exposur ngl net day lead various advers effect marin medaka larva find shed light potenti ecolog risk synthet progestin marin organ | D009990;D014874 | T131;T013 |
36,252,900 | insight characterist mechan vacuum dri technolog municip sludg process vacuum dri effect approach sludg treatment valor howev vacuum dri sludg industri present object studi elucid vacuum dri characterist static sludg crack initi mechan result indic crust sludg surfac high vacuum inhibit dri reduc major crack sludg thick mm inhibit effect weaken decreas sludg thick mm mean dri rate v lowest mpa v decreas increas vacuum degre thick mm decreas dri rate could attribut rapid evapor sludg surfac high vacuum lead crust inhibit crack initi v rais mm suction forc vacuum water much higher resist water diffus small isol pile mm addit studi provid essenti inform improv exist sludg treatment method | D012722;D003890 | T070;T069 |
36,252,899 | recoveri nickel form ni oh plate wastewat contain ni edta use bipolar membran electrodialysi ni often present plate wastewat complex state difficult remov ni use tradit chemic precipit technolog studi bipolar membran electrodialysi system use recov ni form ni oh plate wastewat contain ni ethylenediaminetetraacet acid ni edta without ad chemic reagent stabl structur ni edta destroy h produc bipolar membran obtain free ni combin oh produc bipolar membran form ni oh electrolyt na concentr current densiti initi ni edta concentr moll macm mgl respect ni edta remov h system use treat actual plate wastewat ni edta remov recov number wastewat compart system increas one three current effici increas specif energi consumpt decreas kw hg result x ray diffract studi indic ni oh obtain studi similar commerci ni oh moreov recoveri mechan ni edta analys thus bipolar membran electrodialysi regard effect method recov ni wastewat contain ni edta | D062065;D009532 | T123;T083;T196;T069 |
36,252,897 | sar cov remov mix matrix membran novel applic artifici neural network base simul matlab evalu wastewat reus risk covid outbreak led discoveri sar cov sewag thus wastewat treatment plant wwtps could virus effluent howev whether sar cov erad sewag treatment virtual unknown specif object studi includ determin whether mix matrix membran mmm abl remov sar cov polycarbon pc hydrous manganes oxid hmo pc silver nanoparticl ag np ii compar filtrat perform among differ secondari treatment process iii evalu whether artifici neural network ann employ perform indic reduc sar cov treatment sewag shariati hospit mashhad iran secondari treatment effluent outbreak covid collect wwtp two pc ag np pc hmo process wwtp target rt qpcr employ detect presenc sar cov sewag fraction purpos determin sar cov preval rate treat effluent l effluent specimen collect middl risk low risk treatment mmms pc hmo log reduct valu lrv sar cov log moder risk log low risk wherea pc ag np lrv log moder risk log low risk mmms demonstr robust absorpt perform sampl period least signific lrv record pc ag np pc hmo log log respect | D000086382;D053768 | T047;T073;T067 |
36,252,896 | biodiesel feedstock determin exhaust toxic biodiesel miner diesel blend address climat chang concern reduc carbon footprint caus fossil fuel use like blend ratio renew biodiesel commerci miner diesel fuel steadili increas result biodiesel use becom widespread exhaust toxic unblend biodiesel chang depend feedstock type howev effect feedstock blend fuel less well known aim studi assess impact biodiesel feedstock exhaust toxic blend biodiesel fuel b primari human airway epitheli cell expos exhaust dilut air engin run convent ultra low sulfur diesel ulsd blend soy canola wast cook oil wco tallow palm cottonse biodiesel diesel physico chemic exhaust properti compar fuel post exposur effect exhaust cellular viabil media releas assess h later exhaust properti chang signific fuel cottonse b differ ulsd respect unblend biodiesel exposur palm b result signific decreas cellular viabil p wherea exposur soy b generat greatest number chang mediat releas includ il il tnf p compar air expos control palm b tallow b close follow contrast canola b wco b least toxic mediat g csf tnf signific increas therefor exposur palm b soy b tallow b found toxic exposur canola b wco b least top three toxic bottom three least toxic b fuel consist unblend counterpart suggest feedstock type great impact exhaust toxic even biodiesel compris fuel | D056804;D052638 | T131;T167;T109 |
36,252,887 | adolesc nicotin potenti inhibitori effect racloprid r antagonist phencyclidin sensit psychot like behavior mice associ schizophrenia nicotin addict becom evid adolesc investig interact event might underli earli establish comorbid use phencyclidin evok locomotor sensit proxi model psychot behavior nicotin minipump infus adolesc mice consid involv dopamin receptor schizophrenia addict test role expos mice racloprid adolesc mice either expos nicotin mgkgday receiv singl daili racloprid mgkg sc salin follow phencyclidin inject mgkg sc open field test consecut day acquisit phase acq phencyclidin nicotin challeng sensit test st carri day withdraw ambul escal respons repeat phencyclidin exposur acq increas phencyclidin challeng evidenc develop express locomotor sensit racloprid prevent phencyclidin evok develop sensit howev racloprid pre exposur acq shorten express phencyclidin challeng mice nicotin fail interfer phencyclidin stimulatori effect acq potenti racloprid inhibit first acq day st nicotin histori shorten express phencyclidin evok sensit nicotin challeng impact locomot consist lack nicotinephencyclidin cross sensit conclus result show nicotin worsen may even amelior phencyclidin sensit psychot like behavior adolesc mice potenti racloprid mediat inhibit suggest nicotin transient improv therapeut efficaci medic psychot symptom mechan converg receptor | D010622;D009538 | T121;T131;T109 |
36,252,886 | sex specif behavior effect acut exposur neonicotinoid clothianidin mice although neonicotinoid among major class pesticid affect mammalian nervous system littl known sex differ effect studi aim examin whether neurobehavior effect neonicotinoid clothianidin clo differ sex male femal cbln mice oral administ clo mgkg chronic observ advers effect level noael subject behavior test emot learn function chang neuroact sever brain region concentr clo metabolit blood urin measur acut clo exposur caus sex relat behavior effect decreas locomotor activ elev anxieti like behavior appar male femal addit male specif impair short long term learn memori clo exposur observ novel recognit test barn maze test male domin increas number c fos posit cell observ paraventricular thalam nucleus thalamus dentat gyrus hippocampus relat stress respons learn function respect concentr clo metabolit blood urin higher male result support notion male mice vulner femal neurobehavior effect clo provid novel insight risk assess neonicotinoid mammalian neuron function | D007306 | T131 |
36,252,884 | weather process polyethylen microplast paddi soil system coexist pyrochar hydrochar matter studi base particular test site simul weather process microplast mps paddi soil substanti amount plastic wast especi mps inevit accumul agricultur soil due high consumpt short averag use plastic recent mp pollut becom global environment concern howev insight soil weather process mps paddi soil particular presenc biochar lack studi physicochem properti polyethylen pe mps determin week weather system conduct paddi soil paddi soil pyrochar hydrochar moreov sorption origin weather pe mps toward three typic pollut cadmiumcd bisphenol abpa dimethyl phthalatedmp investig surfac pe mps fractur fold rougher yellow color unit fold oxid paddi soil weather addit crystallin negat charg stronger hydrophil weather pe mps increas compar origin pe mps weather pyrochar hydrochar system caus fissur extens destruct amorph area acceler chemic bio oxid process pe mps result notic chang rough fold yellow color crystallin fold oxygen content fold weather pe mps facilit sorption cd bpa attribut larger specif surfac area abund polar function group increas negat charg site howev sorption dmp pe mps high influenc hydrophob result decreas hydrophob partit sorption weather pe mps overal paddi soil weather affect properti pe mps enhanc sorption cd bpa reduc sorption dmp coexist biochar exacerb paddi soil weather effect insight gain studi assist better understand weather process pe mps agricultur soil | D000080545;D012987 | T122;T167 |
36,252,883 | detect genet analysi escherichia coli tonl sap lake tributari cambodia spatial distribut season variat pathogen antimicrobi resist indic fecal contamin escherichia coli monitor tonl sap lake cambodia tributari low high water season focus impact float villag inhabit boathous e coli concentr float villag cfu ml low high water season respect signific higher lake site cfu ml low high water season respect river cfu ml low high water season respect like fecal materi boathous discharg without treatment lake sampl site remot boathous e coli concentr lower high water season low water season due dilut lake water e coli coloni detect monitor isol pathotyp antimicrobi suscept test beta lactamas gene detect multilocus sequenc type mlst e coli isol diarrheagen e coli dec preval dec float villag low water season higher high water season site season dec isol float villag low water season show high antimicrobi resist includ ampicillin ciprofloxacin frequent possess beta lactamas gene bla tem mlst analysi indic predomin sequenc type st dec isol float villag possibl origin human wherea divers sts detect isol site reveal wide presenc diarrheagen antimicrobi resist e coli tonl sap lake identifi consider infect risk float villag especi low water season | D060106;D004927 | T083;T070;T047 |
36,252,879 | xuanfei baidu formula attenu lps induc acut lung injuri inhibit nf b signal pathway acut lung injuri ali common manifest covid xuanfei baidu formula xfbd use china treat mild common damp toxin obstruct pulmonari syndrom covid patient howev activ ingredi xfbd extens studi mechan action treatment ali well understood | D000086382;D055371 | T047;T037;T067 |
36,252,878 | er xian decoct attenu ovariectomi induc osteoporosi modul fatti acid metabol igfpikakt signal pathway er xian decoct exd tradit chines medicin tcm formula use treat osteoporosi op howev anti op mechan exd yet fulli elucid | D010024;D004365 | T123;T047;T121 |
36,252,877 | protect effect xingnaoj inject ferroptosi cerebr ischemia injuri mcao rat sh syy cell xingnaojingxnjinject tradit chines medicin inject neuroprotect effect wide use treatment stroke mani year | D000079403;D009447;D002545;D018696;D001930;D015427 | T121;T191;T037;T043;T047;T046;T169 |
36,252,876 | molecular mechan anti inflammatori effect plant essenti oil systemat review plant essenti oil peo extract aromat compound plant contain complex mixtur volatil lipophil bioactiv compound ancient egypt arabia greec china peo tradit use aromatherapi various health disord includ pain inflamm | D009822 | T109 |
36,252,875 | gancao fuzi decoct regul thtreg cell imbal rheumatoid arthriti target foxp via mir eastern han dynasti zhang zhongj first record gancao fuzi decoct gcfzd formula synopsi golden chamber report effect safe treatment rheumatoid arthriti ra howev mechan under observ improv helper th regulatori treg cell imbal ra obtain gcfzd report | D001172;D001169;D035683 | T123;T047;T050;T114 |
36,252,874 | deploy metabol heat rate base soft sensor estim control specif growth rate glycoengin pichia pastori human interferon alpha b product lack appropri process model reliabl onlin sensor process variabl bioprocess system pois challeng real time monitor control critic process paramet cpps present investig deal develop non invas soft sensor util metabol heat rate input signal onlin estim specif growth rate est induct phase glycoengin pichia pastori human interferon alpha b huifnb product feedforward strategi employ predetermin exponenti feed methanol induct phase dealt defin setpoint valu sp standard pid control predetermin gain valu regul methanol feed accord deviat sp valu adapt pid gain schedul signific minim deviat sp valu reduc amplitud oscil achiev long term control stabil robust control methanol feed adapt pid result fold increas product huifnb compar standard pid feedforward control respect moreov adapt pid control facilit narrow rang control longer durat h low averag track error enumer scope applic therapeut protein product near futur | D010843;D000432 | T130;T131;T004;T109 |
36,252,872 | imag mass cytometri high dimension singl cell perspect microenviron solid tumour imag mass cytometri imc new technolog integr mass spectrometri high resolut laser ablat immunohistochemistrycytochemistri uniqu high dimension perspect comprehens accur depict complex interact phenotyp signal pathway tumour microenviron wide use solid tumour howev applic scenario imc basic medicin clinic research solid tumour lack systemat introduct classif paper review applic imc depict panorama tumour microenviron reveal tumour spatial heterogen clarifi tumour pharmacolog mechan assist new drug develop dynam evalu efficaci immunotherapi solid tumour | D059016;D009369 | T070;T191 |
36,252,851 | function neuroanatom correl conting judgement conting judgement abil detect relationship event crucial alloc attent resourc reason categor decis make control behaviour environ research suggest alloc attent sensit frequenc conting inform whether constitut negat zero posit relationship aim present studi explor function neuroanatom correl conting judgement differ frequenc whether distinct whether reli common mechan use three conting task within stream paradigm one negat zero posit conting frequenc assess brain activ mean function magnet reson imag fmri particip conting frequenc manipul block allow us determin neural correl three conting task well common area activ conjunct task activ show activ left pariet cortic ba superior tempor gyrus ba interact analysi reveal distinct area main involv later ba medial ba prefront cortic judgment negat conting compar posit zero conting interpret find evid share region may involv code integr updat associ relat distinct region may involv invest attent resourc vari degre comput conting make judgment | D007600;D010296 | T023;T029;T041;T030 |
36,252,850 | oxid stress rvlm mediat sympathet hyperact induc circadian disrupt circadian rhythm play signific role maintain function cardiovascular system emerg studi demonstr circadian disrupt enhanc risk cardiovascular diseas activ sympathet nervous system howev under mechan remain unknown therefor studi aim clarifi role oxid stress rostral ventrolater medulla rvlm sympathet hyperact induc circadian disrupt rat random divid two group normal light dark ld group circadian disrupt cd group sympathet nerv activ rat assess record renal sympathet nerv activ rsna indirect method plasma level norepinephrin ne level oxid stress rvlm detect dihydroethidium probe moreov express level oxid stress relat protein rvlm detect western blot circadian disrupt signific increas blood pressur bp rsna plasma level ne compar ld group cd group exhibit signific depressor respons iv hexamethonium bromid ganglion blocker furthermor reactiv oxygen speci ros product rvlm rat circadian disrupt signific increas addit bp rsna rat circadian disrupt exhibit greater decreas effect microinject tempol superoxid scaveng rvlm compar artifici cerebrospin fluid acsf investig molecular mechan western blot show nuclear factor erythroid relat factor nrf heme oxygenas ho nad p h quinon oxidoreductas nqo signal regul rvlm circadian disrupt rat data suggest oxid stress rvlm mediat sympathet hyperact induc circadian disrupt possibl regul nrfhonqo signal | D051267;D006973 | T123;T047;T116 |
36,252,849 | methyl pattern within utr dat gene function allel utr variant matern patern origin may affect psychopatholog phenotyp children explor studi psychopatholog symptom depressionanxieti vs attent aggress problem children associ alter express datslca gene inherit specif repeat vntr allel could modifi pattern methyl cpgs island utr dat gene accur recruit primari school end four subgroup children homozyg heterozyg born mother father call hem heterozyg born mother father call hef epi genet chang found relat intern extern symptom compar genotyp children exhibit main intern symptom genotyp previous associ adhd sever found children bear utr motif show cpgs uniti anticorrel cpg children show rather demethyl cpg link demethyl cpg found two differ pattern hem hef featur hem children cpgs methyl pattern cpgs demethyl togeth support split unitari destini within hef children status cpgs remain opposit yet pattern de methyl well defin prevail one inherit parent allel may somewhat influenc motif destini heterozig children present work aim identifi novel epigenet biomark exploit fair indic children psychopatholog vulner | D001523;D001289 | T048 |
36,252,843 | pattern report infect reinfect sar cov england one key featur infecti diseas whether infect generat long last immun whether repeat reinfect common former long term dynam driven birth suscept individu latter dynam govern speed wane immun two extrem rang scenario possibl earli wave sar cov under paradigm long last immun recent data particular omicron wave shown reinfect relat common investig report sar cov case england partit data four main wave consid tempor distribut first second report infect show simpl low dimension statist model random scale reinfect captur much observ dynam valu scale k provid inform under epidemiolog pattern conclud consider heterogen risk report reinfect wave age group locat high level reinfect omicron wave estim omicron case previous infect although necessarili previous report infect point reinfect event domin futur covid dynam manuscript submit part theme issu model covid prepared futur pandem | D000084063;D000086382 | T033;T047;T046;T067 |
36,252,842 | effect popul model choic network topolog extinct time pattern dendrit ecolog network model popul habitat network vital understand link process pattern across individu environ ecolog interact popul structur river ecosystem model combin physic structur network biolog process organ use structur function model respect previous studi dendrit river network employ differ function popul model either direct claim impli result illustr general properti actual river system howev studi use differ approach assumpt model popul characterist behavior possibl infer regard system may vari base combin function model spatial structur network studi aim understand differ function model river system produc substanti differ model result therefor whether conclus model depend compar variat extinct time occup proport river network linear trelli dendrit ring lattic topolog use three popul model uniform age class individu base one metapopul base patch occup model dendrit linear trelli structur show notabl differ among extinct time four model differ topolog higher patch occup model compar three popul model signific differ variat patch occup metapopul popul model three popul model differ complex produc broad similar result therefor occup data obtain base local subpopul spatial arrang connect appear sole predictor singl speci metapopul respons conclud output function model robust assumpt vari level detail long contain least detail level individu within habitat node also model network scale popul model includ least detail inform individu far better choic consid popul implicit | D017753;D008954 | T075;T070;T082 |
36,252,826 | attent bias human anxieti across clinic subclin sampl anxieti associ increas attent captur cue signal danger various cognit model attribut onset mainten anxieti symptom maladapt select inform process brief review describ evid relat anxieti attent bias toward threat discuss neurobiolog anxieti relat differ threat bias summar work investig development origin attent bias toward threat examin effort translat threat bias research clinic intervent futur direct area discuss includ use novel analyt approach improv character threat process relat brain network clarifi role cognit control develop attent bias toward threat need larger well control random clinic trial examin moder mediat treatment respons ultim work import implic understand etiolog interven anxieti difficulti among children adult | D000070379 | T041 |
36,252,825 | suggest conclus independ meta analysi auditori benefit learn play music instrument commentari literatur music train suggest benefit activ auditori skill ie near transfer general cognit abil ie far transfer howev posit taken result skeptic rather argu studi posit outcom suffer methodolog issu imped infer causal context debat conduct independ meta analysi similar one recent publish neve et al also show auditori benefit music train meta analysi suggest avail evid suffici reach firm conclus intervent design qualiti featur random activ control still scarc moreov review studi measur auditori skill test base samediffer judgment reli short term memori therefor less sensit chang produc musicmak experi although evid conclus result line observ cognit stimul activ suggest posit impact music train auditori skill thus avail evid support extrem version skeptic | D009146 | T170 |
36,252,775 | crisprca induc knockout reveal role abcb respons temozolomid carmustin lomustin glioblastoma multiform glioblastoma multiform gbm common malign brain tumor limit therapeut option besid surgeri chemotherapi use temozolomid carmustin lomustin main pillar therapi howev therapi success limit prognosi still poor one restrain factor drug resist caus drug transport atp bind cassett famili eg abcb abcg locat blood brain barrier tumor cell activ efflux xenobiot includ drug eg temozolomid lead low intracellular drug concentr subsequ insuffici anti tumor effect nevertheless role efflux transport gbm controversi discuss present studi analyz role abcb abcg gbm cell show abcb margin abcg relev appli crisprca deriv abcb knockout respons temozolomid signific augment demonstr decreas cell number p lt prolifer rate p apoptosi increas p carmustin decreas cell g phase detect point cell cycl arrest abcb knockout p lomustin howev loss abcb alter respons treatment overal studi show abcb involv activ transport temozolomid tumor cell diminish respons temozolomid interest loss abcb also affect respons lipophil drug carmustin find show abcb relev blood brain barrier also tumor cell diminish success chemotherapi | D005909 | T191 |
36,252,774 | symmap databas tmnp algorithm reveal huanggui tongqiao granul allerg rhiniti ifn mediat neuroimmuno modul allerg rhiniti ar seri reaction allergen mediat immunoglobulin e ige one common allerg diseas affect children tradit chines medicin due divers regulatori function may offer new strategi ar therapi huanggui tongqiao granul htg chines formula consist twelv herb long prescrib patient ar aim studi determin possibl target action mechan htg ar treatment symmap databas tmnp algorithm employ show interferon gamma ifn gamma act molecular link immun neural circuit involv key target enrich immun virus relat signal pathway indic neuroimmunomodulatori potenti htg ar mous model establish ovalbumin ova challeng use verifi therapeut effect htg vivo htg signific reliev ar symptom nasal mucos inflamm reduc ova specif ige level balanc ifn gammail ratio moreov transcript profil base clinic data present blood cell specif ifn gamma co express gene modul bim underexpress ar patient valid potenti ifn gamma target ar collect find suggest htg could promis candid drug ar | D009297;D065631 | T023;T024;T047 |
36,252,773 | toll like receptor metabol dysfunct associ fatti liver diseas metabol dysfunct associ fatti liver diseas mafld character accumul lipid liver steatosi predispos individu liver steatosi progress inflamm fibrosi cirrhosi hepatocellular carcinoma pathogenesi mafld complex incomplet understood involv various steatogen pro inflammatori fibrogen process hyperactiv innat immun system hepat toll like receptor tlrs contribut pathogenesi mafld product intestin microbiota danger signal damag hepatocyt constitut key ligand tlrs promot mafld tlrs promot develop progress mafld induct pro inflammatori pro fibrogen cytokin sever nutraceut therapeut agent improv mafld part inhibit hepat tlrs herein review avail literatur hepat tlr express signal crosstalk gut microbiota hepat tlrs contribut tlrs pathogenesi mafld also highlight implic therapeut approach mafld base modul tlr signal | D005234;D008113;D065626 | T047;T191 |
36,252,772 | block cytohesin arf axi secinh amelior osteoclast induc bone loss via attenu jnk mediat ire endoribonucleas activ cytohesin guanin nucleotid exchang factor activ arf arf involv various biolog process includ signal transduct cell differenti cell structur organ surviv nevertheless lack evid reveal role cytohesin osteoclast differenti develop osteoporosi studi find cytohesin arf posit regul osteoclast differenti function block cytohesin arf axi secinh genet silenc cytohesin inhibit osteoclast format function vitro vivo treatment secinh amelior ovariectomi induc osteoporosi mechanist rna sequenc combin molecular biolog methodolog reveal regulatori function cythohesin arf axi osteoclast differenti main depend activ jnk pathway addit common viewpoint jnk activ ire via kinas activ found jnk act upstream regul endoribonucleas activ ire promot xbp splice secinh silenc cytohesin inhibit jnk activ ire endoribonucleas activ lead suppress osteoclast differenti taken togeth find add new insight regul jnk ire reveal inhibit cytohesin arfjnkir axi might repres potenti new strategi treatment post menopaus osteoporosi | D020727;D010024 | T047;T126;T116 |
36,252,763 | strategi control growth cyanobacteria recoveri use adsorpt desorpt studi adsorpt strategi use diethylenetriamin modifi cotton fiber deta cotton investig control target cell aqueous phase adsorpt remov aeruginosa use deta cotton show decreas cell concentr cellsml cellsml h concentr microcystin increas remov process also increas amin group surfac confirm surfac character ft ir xps desorpt process perform analyz total lipid fatti acid content potenti use bio energi resourc adsorb cell recov desorpt lipid content composit suitabl use biodiesel raw materi adsorpt base approach might provid feasibl solut counteract environment issu hab also recov energi resourc harm cyanobacteri speci | D046931;D000458 | T007 |
36,252,762 | enhanc biolog denitrif addit novel srna pda antibiot pressur paracoccus denitrifican adapt complex environment chang srnas play crucial role process work aim identifi antibiot induc srna regul denitrif explor potenti function enhanc process target predict indic complementari base pair denitrifi gene nosz srna pda anaerob cultur p denitrifican atcc presenc florfenicol ff result signific decreas nosz pda gene express p two addit denitrifi isol contamin sediment co cultur atcc generat consortium induc pda express strain also ad result reveal pda signific enhanc napa napb norb express differ type denitrifi ff condit p studi identifi srna pda novel posit regul denitrif may realiz effici treatment antibiot contamin wastewat microbi agent | D058440;D010231 | T007;T067 |
36,252,761 | reveal mechan micro aerat enhanc volatil fatti acid product swine manur micro aerat consid new strategi improv volatil fatti acid vfas product agricultur wast studi investig effect mechan micro aerat air oxygen vfas product swine manur result show air micro aerat signific improv effect highest vfas gl increas moreov mix effect differ micro aerat limit microbi communiti signific vari firmicut bacteroidota domin hydrolyt acidogen bacteria air micro aerat preferenti promot electron transfer activ energi generat methanosarcina methanocorpusculum methanobrevibact adapt environment chang accord differ oxygen toler consumpt convers vfas methanogen slow air micro aerat condit studi reveal mechan micro aerat improv vfas product swine manur provid theoret basi micro aerat regul optim | D008372;D005232 | T123;T167;T109 |
36,252,760 | lignocellulos degrad penicillium janthinellum enzym influenc variabl secretom uniqu set feedstock characterist substrat characterist protein affect lignocellulos hydrolysi hypercellulolyt fungus penicillium janthinellum ncim pj investig hydrolysi rate pj enzym high upto reaction complet initi h comparison hydrolyt effici differ pretreat biomass indic greatest negat effect impart lignin suggest improv ligninas activ pj enzym may help improv hydrolysi larger pore size higher crystallin substrat favor enzym penetr process hydrolysi posit influenc hydrolysi effici alkali pretreat substrat fpug pj cellulas releas sugar equival use fpug commerci biomass hydrolyz enzym correl analysi protein includ cazym identifi whose abund secretom posit correl cellulas activ cultur filtrat protein may consid primari driver fpasecmcasepnpgasexylanas activ pj | D008031;D000089282 | T123;T116;T109 |
36,252,754 | small peptid glutathion induc biofloccul enhanc food applic potenti chlorella pyrenoidosa exist floccul use enhanc harvest effici microalga howev harvest biomass contain residu unsuit food applic studi small peptid induc biofloccul techniqu develop harvest microalga biomass free impur seven day cultiv glutathion floccul effici chlorella pyrenoidosa achiev settl h nutrient composit floc depict higher protein mgl lipid mgl content control mgl amino acid profil floc show presenc essenti amino acid untreat cell omega polyunsatur fatti acid accumul floc extracellular polymer substanc induc biofloccul appear mark floc mgl compar control mgl studi provid novel insight residu free algal harvest method obtain nutrit enrich biomass | D002708;D058086 | T204;T002 |
36,252,753 | perform mechan nitrat remov aerob denitrifi bacterium ji strong autoaggreg capac new strain ji strong autoaggreg aerob denitrifi bacteria screen nitrat remov abil autoaggreg mechan ji analyz use nitrogen balanc genom technolog nitrat remov rate mg n lh ph cn strain ji remov nitrat via aerob denitrif dissimil pathway remov ammonium via assimil pathway nitrat convert cellular compon aerob condit complex nitrogen metabol gene detect strain ji c di gmp mediat motil behavior ji bind fleq pilz protein regul express psla furthermor mechan autoaggreg verifi extracellular polymer substanc analysi meanwhil nitrat remov rate strain ji mg n lh wastewat thus strain ji good prospect applic treatment nitrat wastewat | D009566;D058440 | T197;T067 |
36,252,752 | increas extracellular cellulas activ recombin saccharomyc cerevisia engin cell wall relat protein improv consolid process carbon neutral lignocellulos biomass sustain bioproduct usingcarbon neutral feedstock especi lignocellulos biomass attract increas attent due concern climat chang carbon reduct consolid bioprocess cbp lignocellulos biomass use recombinantyeast saccharomyc cerevisiaei promis strategi forlignocellulos biorefineri howev econom viabil restrict low enzym secret levelsfor effici cbp mig spsc isol industri yeast encod glucos repress regul deriv overexpress increas extracellular cellobiohydrolas cbh activ observ unexpect decreas cell wall integr studi reveal disrupt ofcwp ygp anduth function relat tomig spsc also enhanc cbh secret subsequ improv cellulas product achiev simultan disrupt ofygpand overexpress ofs remark increas extracellular cbh activ fold control strain result provid novel strategi improv cbp yeast bioconvers carbon neutral biomass | D012441;D002480 | T121;T116;T004;T126 |
36,252,751 | novel two stage process effect treatment swine wastewat use chlorella sorokiniana ak base algal bacteri consortium semi continu oper studi aim develop eco friend effect treatment swine wastewat sww use design microalga bacteria consortium function algal bacteri consortium develop sww deriv bacteria chlorella sorokiniana ak light intens molm inoculum size gl microalga bacteria optim semi batch oper treat sww result cod bod tn tp remov effici respect novel two stage process initi bacteri start stage follow microalg inocul appli attain stabl organ carbon remov addit satisfactori tn tp remov full strength sww treat strategi cod bod tn tp remov effici respect biomass consist carbohydr indic potenti feedstock biochar product addit effluent met standard effluent discharg taiwan | D002708;D058086 | T204;T002 |
36,252,750 | high cell densiti heterotroph cultiv microalga chlorella sorokiniana fzu achiev ultra high lutein product effici chlorella sorokiniana receiv particular attent promis candid microalg biomass lutein product work heterotroph cultiv explor improv lutein product effici lutein rich microalga c sorokiniana fzu flask cultiv result show highest lutein product achiev c initi cell concentr gl furthermor six type fed batch strategi base nutrient composit concentr examin use l ferment among ultra high lutein product mgl product mgld lutein content mgg achiev fed batch f ie puls feed concentr urea n medium achiev fold nutrient concentr lutein product perform achiev much higher report valu work demonstr heterotroph cultiv c sorokiniana fzu propos fed batch strategi could signific enhanc product perform commerci viabil microalga deriv lutein | D002708;D058086 | T204;T002 |
36,252,738 | expuls augusta dejerin klumpk salptrir hospit pierr mari reveng augusta dejerin klumpk ahead time extens contribut field neuroanatomi neurolog achiev intern recognit despit great contribut world neurolog expel salptrir hospit due rivalri mutual hatr pierr mari rival jule djerin husband collabor | D009462 | T091 |
36,252,634 | physicochem structur function properti pomelo spongi tissu pectin modifi differ green physic method comparison pectin valuabl bioactiv ingredi practic applic limit mani area due high molecular weight complex structur work effect differ physic method ultra high pressur ultrason high temperatur cook physicochem structur function characterist pomelo spongi tissu pectin pp investig ultra high pressur treatment mpa min decreas degre esterif de degre acetyl da pp pp subject ultrason treatment w min exhibit highest esterif degre galacturon acid content gala mgg degrad enthalpi jg meanwhil pp treat high temperatur cook hct c min lowest acetyl degre molecular weight da gala content mgg sem xrd result show degrad effect high temperatur pp evid physic modif method remark modifi pectin solut show lower viscos compar untreat pp solut among pp sampl higher antioxid activ mmol teg frap mmol teg orac valu found hct treat pp moreov ultra high pressur ultrasound modifi pectin reveal better emulsifi activ emulsifi stabil unmodifi pp result studi indic pp could treat achiev desir function applic three physic modif method | D010368;D005638 | T123;T121;T109;T168;T002 |
36,252,632 | mechan strong chitin filament wet spin chitin nanofib aqueous naoh herein facil wet spin strategi use fabric mechan strong chitin filament aqueous naoh solut use chitin nanofib chnfs hypothes reach high mechan perform import preserv crystallin structur chitin fabric explor possibl chnfs disintegr squid pen mild procedur show uniform diamet nm length micron high aspect ratio interest find gel like chnf filament direct form aqueous naoh without use organ ionic agent gelat chnf alkali treatment contribut construct strong nanonetwork thus facilit format high strength filament result chitin filament show high tensil strength young modulus mpa gpa respect investig util flexibl sensor advantag strategi includ lack use toxic solvent achiev high mechan perform chitin filament believ wet spin approach may promot function util chitin develop high strength filament smart textil biosensor structur reinforc | D002686;D057139 | T123;T073;T109 |
36,252,628 | effect freez assist cross link structur rheolog properti potato starch order achiev prepar cross link cl potato starch maximum degre substitut freez pre treatment fs differ mode three day freez two freez thaw cycl day freez conduct thereaft nativ frozen cross link starch character morpholog structur past properti well alkalin intrins viscos regard obtain result freez pre treatment found effici method achiev high level cross link nativ mode freez pre treatment expos pocl reagent crystallin ratio cm increas nativ potato starch nps cross link nativ potato starch cl cross link freez thaw starch cl treat pocl data obtain intrins viscos line power law model cross link starch pocl exhibit lowest k valu highest n valu impli lower shear thin behavior cross link starch freez pre treatment cl nativ starch sum low peak viscos determin rva intrins viscos u tube viscomet could also explain high level cross link low swell power cl | D011198 | T168;T002 |
36,252,627 | soybean solubl polysaccharid prevent obes high fat diet induc rat via lipid metabol regul soybean solubl polysaccharid ssps report possess anti obes activ improv metabol syndrom unfortun under mechan well understood treat high fat diet hfd spragu dawley rat mg per kg ssps ssps treatment signific decreas bodi weight p liver index valu p well concentr level triglycerid tg total cholesterol tc low densiti cholesterol ldl c inflammatori cytokin serum furthermor uncov differ express protein p high involv lipid metabol process addit ssps treatment fatti acid bind protein downregul consist vivo result howev peroxisom prolifer activ receptor express liver tissu regul contradictori vitro result deduc two differ lipid metabol mechan exist vivo vitro furthermor vitro experi ssps exert lipid lower effect altogeth studi result provid overview ssps induc chang liver proteom could help us understand molecular mechan ssps allevi obes | D059305;D050356 | T061;T044 |
36,252,625 | ultrafiltr isol structur effect hn induc acut lung injuri heteropolysaccharid houttuynia cordata previous studi show crude houttuynia cordata polysaccharid chcp exert therapeut effect acut lung injuri induc influenza virus iav mice acid heteropolysaccharid h cordata name hcpm mw kda obtain direct chcp use sequenti ultrafiltr membran column backbon hcpm consist manp galpa rhap rhap main branch glucan arabinan galactan substitut c manp c rhap structur inform valid oligosaccharid sequenc analysi use uplc esi ms furthermor hcpm exhibit potent anti complementari activ ch valu gml vitro signific attenu iav induc lung gut injuri vivo inhibit viral replic reduc inflammatori respons suppress complement overactiv result suggest hcpm might key h cordata substanc pulmonari infect treatment | D052859;D053118;D055371 | T005;T002;T204;T037 |
36,252,624 | baicalein modul mitochondri function upregul mitochondri uncoupl protein ucp express brown adipocyt cytotox comput studi obes fatti liver type diabet non alcohol fatti liver diseas nafld metabol diseas caus excess food consumpt exist drug molecul negat side effect caus diseas develop orlistat caus angioedema menstrual irregular megestrol acet caus hypertens insomnia enhanc lipid consumpt increas nonshiv thermogenesi target mitochondri uncoupl protein ucp express adipocyt could auspici treatment strategi obes metabol disord associ obes | D052437;D003924 | T047;T025 |
36,252,623 | chitosanhyaluron acid polyanion bilay appli carbon acid advanc coat intellig antimicrobi properti improv biolog prosthet heart valv tight bond shield coat biomatrix signific enhanc function medic devic bioprosthes particular work obtain polyelectrolyt coat biomatrix sequenti deposit chitosan hyaluron acid ha solut carbon acid pressur approach make possibl obtain hybrid biomatrix firm bond polym screen due electrostat bond polyion high precis analysi use tritium label show fold increas quantiti ha carbon acid pressur compar convent method presenc chitosan layer increas ha adsorpt due electrostat interact differ charg polym antimicrobi result show possibl implement induc antimicrobi respons due lysi upper layer coat ha releas antimicrobi agent case growth pathogen bioprosthesi | D048271;D000890 | T121;T109 |
36,252,622 | zinc ion prevent synuclein aggreg enhanc chaperon function human serum albumin metal ion present cellular microenviron implic driver aggreg amyloid form protein zinc zn ion report direct interact synuclein causat agent parkinson diseas neurodegen diseas promot aggreg small intrins disord protein idp ie understand molecular factor drive misfold aggreg challeng sinc method use routin studi protein structur effect idp report atom detail zn bind physiolog relev condit use proton less nmr techniqu appli high dynam system like idp also examin human serum albumin hsa abund protein human blood bind whether zn andor ionic strength affect conclud zn enhanc anti aggreg chaperon role hsa reli protect hydrophob n termin nac region rather polar negat charg c terminus suggest previous undocu role zn hsa function aggreg | D051844;D064267 | T123;T116 |
36,252,613 | longitudin effect estrogen mandibular growth chang cartilag growth period rat estrogen steroid hormon induc skelet growth affect endochondr ossif long tubular bone growth plate growth period howev effect estrogen endochondr ossif mandibular condylar cartilag unclear studi ovariectom wistarst rat use investig longitudin effect estrogen mandibular growth rat administ differ dose estrogen longitudin micro comput tomograph scan histolog stain elisa plasma growth hormon perform examin effect estrogen mandibular growth result show mandibular growth suppress throughout growth period estrogen dose depend manner addit long term administr high dose estrogen rat result signific increas growth hormon throughout growth period signific circular cell nuclei prolif layer intens stain cartilag matrix subchondr bone signific suppress estrogen receptor er alpha beta express mandibular cartilag howev regardless estrogen concentr posterior part mandibular cartilag er express extend hypertroph prolif layer result indic estrogen suppress mandibular growth throughout growth period addit influenc endochondr ossif via effect er | D002356;D008335 | T023;T024 |
36,252,595 | paul bout short life psychognomi brazil paul bout belgian pedagogu roman cathol priest founder psychognomi person diagnost system combin phrenolog sever relat practic typolog craniofaci measur physiognomi grapholog etc bout fragil health therefor unlik travel brazil despit famous book rich conserv religi thought translat portugues publish ecclesiast support doctrin acquir good reput among brazilian member clergi politician teacher militari personnel lay scholar medic doctor found brazilian institut devot studi diffus psychognomi publish two volum psychognomi treatis institut activ earli social interest subject rapid vanish | D002410;D010792 | T078;T098;T170 |
36,252,594 | consensus brazilian headach societi sbce prophylact treatment episod migrain part brazilian headach societi sociedad brasileira de cefaleia sbce portugues nomin committe author aim establish consensus recommend regard prophylact treatment episod migrain base articl publish worldwid literatur well person experi migrain affect billion peopl around world million brazilian addit underdiagnos undertr disord well known within medic communiti neurologist especi among headach specialist need dissemin knowledg prophylact treatment migrain purpos togeth need drug updat expand knowledg diseas frequenc intens durat impact perhap progress migrain consensus develop follow full onlin methodolog group review wrote pharmacolog categori drug use end process met read establish conclus document drug class studi anticonvuls tricycl antidepress monoclon anti calcitonin gene relat peptid anti cgrp antibodi beta blocker antihypertens calcium channel inhibitor antidepress select serotonin reuptak inhibitor ssris dual action antidepress drug polytherapi hormon treatment anti inflammatori triptan minimum prophylaxi scheme miniprophylaxi cover specif chapter drug class studi part consensus anticonvuls tricycl antidepress monoclon anti cgrp antibodi beta blocker | D008881;D017367 | T121;T047 |
36,252,593 | systemat review pharmacolog manag creutzfeldt jakob diseas option far creutzfeldt jakob diseas cjd spongiform encephalopathi manifest rapid progress dementia syndrom current cjd cure mani patient die within first year drug studi option manag condit | D007562;D017096 | T047 |
36,252,592 | record cutan silent period paramet hereditari acquir neuropathi cutan silent period csp interrupt muscl activ pain stimul sensori nerv | D002607;D011115 | T047 |
36,252,591 | sleep disord multipl sclerosi case control studi use paulo epidemiolog sleep studi episono databas sleep disord obstruct sleep apnea restless leg syndrom preval general popul patient chronic diseas multipl sclerosi ms | D009103;D012148;D020181;D012893 | T047;T048 |
36,252,590 | corneal confoc microscopi patient distal symmetr polyneuropathi compar control diabet neuropathi dn common clinic condit throughout world diagnost test current recommend low sensit electromyographi invas skin biopsi new techniqu develop identifi earli involv peripher nerv advent corneal confoc microscopi ccm reduct corneal innerv patient dn observ | D003929;D011115 | T047 |
36,252,589 | character nigroestriat system sampl patient amyotroph later sclerosi coexist amyotroph later sclerosi al clinic form parkinson diseas pd although uncommon found greater degre one would expect chanc patholog mechan al pd still fulli understood coexist two diseas suggest could share mechan common | D000690;D019636 | T047 |
36,252,588 | store forward teleneurolog result larg brazilian citi neurolog high demand specialti long wait line patholog requir rapid decis make technolog telemedicin allow neurolog patient faster access special assess store forward telemedicin specialist physician evalu data collect general practition optim screen | D009462;D017216 | T058;T091 |
36,252,587 | valid ketogen diet adher questionnair keto check ketogen diet therapeut option control drug resist epilept seizur difficult complianc standard due advers effect psychosoci factor dietari restrict | D055423 | T061 |
36,252,586 | cognit impair elev peripher cytokin breast cancer patient receiv chemotherapi anthracyclin base regimen fluorouracil doxorubicin cyclophosphamid fac cyclophosphamid epirubicin fluorouracil cef non anthracyclin base regimen cyclophosphamid methotrex fluorouracil cmf wide use neoadjuv chemotherapi breast cancer patient | D000971;D001943;D060825 | T061;T191;T048 |
36,252,585 | evalu risk factor recurr develop epilepsi patient febril seizur although febril seizur fs general consid benign self limit differ regard risk factor prognosi develop epilepsi | D004827;D003294 | T033;T047 |
36,252,584 | hospit servic ischem stroke patient brazilian countrysid still stroke one common caus death incapac world benefit reperfus therapi hospit neurolog intens care unit icus undeni howev treatment wide avail continent size countri like brazil | D002545;D019161;D000083242;D020521 | T121;T047;T046;T109 |
36,252,569 | bntb induc neutral non neutral antibodi function sar cov diminish age sever acut respiratori syndrom coronavirus sar cov variant renew concern decreas vaccin neutral weaken efficaci howev prevent infect vari protect diseas remain implic immun beyond neutral vaccin efficaci polyclon antibodi function fab domain neutral virus fc domain induc non neutral respons via engag fc receptor immun cell understand vaccin promot protect leverag sera sar cov uninfect individu two dose bntb mrna vaccin show neutral activ clinic isol wild type five sar cov variant includ omicron ba link fcriiiacd non neutral effector function associ post translat afucosyl sialyl vaccin specif antibodi polyfunct neutral non neutral breadth magnitud coordin diminish age thus studi fc function addit fab mediat neutral provid greater insight vaccin efficaci vulner popul elder sar cov novel variant | D014765;D000086382 | T129;T047;T121;T067 |
36,252,566 | social anxieti disord updat happen one behav suppos embarrass insuffici manner howev short term feel shame self doubt usual remain without signific howev excess persist fear signific avoid behaviour may case social anxieti disord sas articl provid overview current status aetiolog diagnosi therapi sas | D000072861;D010698 | T048 |
36,252,564 | transcript function analys neoantigen specif cd cell profound respons anti pd l metastat merkel cell carcinoma merkel cell carcinoma mcc often respond pd pathway blockad regardless tumor viral status case driven merkel cell polyomavirus mcpyv prior studi character tumor specif cell respons mcpyv typic cd littl known cell respons uv induc neoantigen | D015266;D059965;D012878 | T005;T191 |
36,252,561 | phasor base multi harmon unmix vivo hyperspectr imag hyperspectr imag hsi paramount techniqu biomed scienc howev unmix quantif spectral compon challeng task tradit unmix reli algorithm need spectroscop paramet fluoresc speci sampl phasor base multi harmon unmix method requir empir measur pure speci comput pixel wise photon fraction everi spectral compon use simul demonstr feasibl approach compon explor use ad th unknown compon repres autofluoresc simul show method success use typic confoc imag experi pixel photon count proof concept test method live cell use common commerci dye organell label easili accur separ final challeng method introduc solvatochrom probe dodecanoyl n n dimethyl naphthylamin laurdan intend measur membran dynam specif subcellular membran bound organell take advantag linear combin organell probe laurdan succeed monitor membran order golgi apparatus mitochondria plasma membran vivo cell quantit compar phasor base multi harmon unmix method help expand outreach hsi democrat use communiti requir special knowledg | D007848;D015081 | T123;T131;T109 |
36,252,558 | effect driver gas composit product scale friedland waveform open end shock tube model evolut modern warfar increas use improvis explos devic i increas blast induc traumat brain injuri btbi among militari personnel civilian increas preval btbi necessit btbi model result proper scale injuri model organ use primari laboratori model btbi shock tube wherein compress gas ruptur thin membran generat shockwav generat shock wave proper scale human rodent subject mani pre clinic model strive short durat high peak overpressur fit friedland waveform ideal represent blast wave larg varieti factor experiment character attempt creat ideal waveform howev found current research gas composit use drive shock wave format lack better understand effect driver gas waveform produc util previous establish murin shock tube btbi model conjunct sever distinct driver gass agreement previous find helium produc shock wave close fit friedland waveform contrast plateau like waveform produc gase peak static pressur exit shock tube total pressur cm exit strong negat correl densiti gas use helium least dens gas use produc highest peak overpressur densiti driver gas also exert strong posit effect durat shock wave helium produc shortest durat wave due abil produc friedland waveform produc waveform follow proper injuri scale guidelin helium ideal gas use shock tube model btbi | D001753;D001930 | T037 |
36,252,552 | uhplc esi msms assay quantif endocannabinoid cerebrospin fluid use surrog calibr surrog matrix approach endocannabinoid endogen lipid main function recogn act neuromodul cannabinoid receptor dysregul endocannabinoid system implic various patholog inflammatori neurodegen diseas studi describ sensit uhplc msms method analysi trace level endocannabinoid cerebrospin fluid sampl analyt cover compris arachidonoylglycerol ag analys sum due interconvers arachidonylglycerol ether age anandamid aea n linoleoyl ethanolamid lea n palmitoyl ethanolamid pea n oleoyl ethanolamid oea analyt extract biofluid simpl monophas procedur involv protein precipit acetonitril mecn analyt method base chromatograph separ analyt solid core core shell superfici porous particl column cortec c gradient elut chang proport water acetonitril constant concentr formic acid provid reason separ analyt close elut analyt intern standard minim matrix effect biolog sampl specif detect endocannabinoid tripl quadrupol tandem mass spectromet electrospray ionis esi select reaction monitor srm mode use provid good assay select develop method requir minut volum biolog sampl l achiev excel sensit lower limit detect pm biolog sampl linear calibr achiev rang pm aea pm ag pm ag pm lea oea pm age pea aea csf method valid reveal relat error rang lloq remain valid rang precis accept rang rsd lloq remain level well final use quantifi endocannabinoid human cerebrospin fluid obtain donor accur quantif endogen compound biolog sampl achiev use two differ princip approach surrog matrix aea ag oea age lea pea surrog calibr aea evalu use pass bablok regress concentr median csf sampl patient suffer cns infect control found around pm ag pm aea age lea pm pea pm oea | D063388;D053719 | T063;T123;T109 |
36,252,521 | kaempferol suppress acut coliti regul efflux transport bcrp mrp bioavail flavonoid low effect vivo howev mechan efficaci flavonoid elucid kaempferol typic flavonoid preliminari research indic kaempferol signific anti colon cancer anti inflammatori effect report previous tripl recycl pathway signific increas local bioavail flavonoid prolong resid time flavonoid liver intestin like mode flavonoid exert local efficaci notabl efflux transport et breast cancer resist protein bcrp multi drug resist associ protein mrp main regulatori molecul enterohepat tripl recycl pathway thus current studi explor regul kaempferol bcrp mrp role bcrp mrp suppress dextran sulfat sodium dss induc coliti kaempferol herein four mous model construct ultra high perform liquid chromatographi tandem mass spectrometri uhplc msms method establish simultan quantifi kaempferol metabolit investig oral pharmacokinet characterist tissu distribut compound bcrp mrp mice movement kaempferol via enterohepat tripl recycl block prevent therapeut effect compound acut coliti inhibit bcrp mrp defect hinder efflux kaempferol phase ii metabolit increas plasma level studi reveal dispos kaempferol regul et bcrp mrp import result help elucid mechan kaempferol suppress transform coliti colon cancer | D003092;D009369 | T047;T191 |
36,252,517 | estrogen defici aggrav fluorid induc small intestin mucosa damag junction complex protein express disord rat investig effect estrogen defici small intestin mucos barrier induc fluorid f f exposur model ovariectomi ovx rat surgic remov ovari non ovx rat normal condit establish ad sodium fluorid naf mgl calcul f ion drink water day intestin mucos histomorpholog mucos barrier function protein express level tight junction tjs adhes junction aj desmosom evalu duodenum jejunum ileum hematoxylin eosin stain bromo deoxyuridin brdu measur show excess f induc damag intestin epitheli cell inhibit prolifer intestin epitheli cell eventu decreas number goblet cell decreas glycoprotein secret indic alcian blue period acid schiff ab pas period acid schiff pas stain immunofluoresc analysi demonstr excess f decreas protein express level occludin zonula occluden zo e cadherin desmoplakin p p enhanc express claudin p suggest cell cell junction disrupt collect f exposur impair small intestin mucos barrier induc damag intestin epitheli cell inhibit intestin epitheli cell prolifer disord junction complex protein express block synergi intercellular communic aggrav mucos injuri particular estrogen defici exacerb f induc enterotox provid new explan develop sever intestin diseas postmenopaus women high f area | D005459;D007413 | T121;T197;T024;T023 |
36,252,516 | arsenolipid reduc butyr level influenc human gut microbiota donor depend way arsenolipid organ arsenic speci variabl toxic accur assess risk deriv arsenic contamin seafood intak requir studi interplay arsenolipid human gut microbiota research use vitro mucos simul human intestin microbi ecosystem shime assess effect defin chemic standard arsenolipid asfa ashc simul healthi human gut microbiota n microbi deriv metabolit quantifi gas chromatographi microbiota structur character rrna gene sequenc specif reduct butyr product control mm asfa mm ashc mm n donor concomit reduct abund lachnospiracea ucg group faecalibacterium genus observ albeit donor depend manner furthermor increas escherichiashigella proteobacteria fusobacterium abund observ arsenolipid treatment depend individu microbiota background alter microbi function microbi communiti structur suggest detriment effect arsenolipid intak toward commens gut microbiom consequ human health | D000069196;D001151 | T121;T007;T131;T196;T001 |
36,252,515 | arsenic inhibit citric acid accumul via downregul vacuolar proton pump gene express citrus fruit citric acid content critic qualiti determin citrus citrus spp fruit although arsenic effect reduc citric acid content improv citrus fruit qualiti advers environment effect discoveri nontox substitut hamper incomplet elucid under mechan action citrus fruit metabol transcriptom physiolog analys employ investig action citric acid accumul discov mechan action citrus enzym activ relat citrat biosynthesi inhibit content involv metabolit reduc treat fruit howev proton pump gene citph citph control vacuolar citric acid accumul transcript factor gene cittt citmyb regul citph citph downregul oxid stress respons gene upregul treat fruit reactiv oxygen speci ros treatment also downregul cittt citmyb juic cell mitochondri ros product rate increas treat fruit iii potent stimul isol mitochondria overproduc ros compar v result indic inhibit citric acid accumul may primarili due transcript downregul citph citph cittt citmyb induc oxid stress signal may oper upstream downregul acid regul gene mitochondri thiol protein may princip target action citrus fruit | D002957;D001151 | T121;T168;T196;T131;T002 |
36,252,514 | pfaffia glomerata hyperaccumul candid cd zn toler absorpt transfer distribut pfaffia glomerata candid phytoremedi due high biomass high bioaccumul effici multipl heavi metal essenti evalu toler absorpt transfer distribut multipl heavi metal current studi evalu toler absorpt transfer distribut p glomerata cdpbcuzn combin contamin environ two hydropon experi result demonstr p glomerata affect cdpbcuzn exposur except cdpbcuzn treatment signific decreas stem biomass singl cd pb cu zn exposur root p glomerata absorb cdpbcuzn order cd zn pb cu almost pb cu accumul plant root hard transfer aboveground part therefor order total cdpbcuzn extract singl plant multipl cdpbcuzn exposur concentr cd zn pb cu bioconcentr factor bcf cd zn root stem leav increas concentr cd zn solut contrast cd zn bcfs cu pb stem leav element distribut pb cu zn mn stem p glomerata dispers indic stem p glomerata detoxif mechan distribut metal area low biolog activ total amount tartar acid critic acid doc secret p glomerata root decreas increas cdpbcuzn exposur howev investig need unravel interact lmwoa secret root p glomerata heavi metal | D019216;D027703;D012989 | T131;T196;T002 |
36,252,513 | intestin flora variat reflect short term damag microplast intestin tract mice potenti toxic microplast mps organ attract extens attent howev due subacut toxic mps biolog effect hard verifi short term exposur experi track dynam gut microb mice model util evalu toxic composit mps pe pet pp ps pvc day digest exposur physiolog indic normal control group bodi weight serum cholesterol level insignific chang wherea histopatholog examin treatment group suffer colon tissu damag among ps inflammatori cell moreov high throughput sequenc result reveal great variat intestin flora treat mice ratio bacteroidet firmicut pe pet pp treatment group heighten relat abund ruminococcacea lachnospiracea increas signific famili level genus level alistip bacteria ps treatment group signific decreas associ obes risk indic mps induc inflammatori respons would interfer dynam intestin flora caus health effect live organ work shed light mps toxic short term exposur suppli research paradigm mps health risk assess | D000080545;D000069196 | T122;T007;T001 |
36,252,512 | contrast dynam manur born antibiot resist gene differ soil antibiot resist gene arg import biolog contamin factor soil system pose direct indirect threat soil health food safeti human health ubiquit pollut arg usual implic applic organ manur agricultur soil ecosystem howev littl known transmiss fate arg manur input concern differ soil herein transmiss potenti tempor dynam manur associ arg character three differ agricultur soil collect jiangxi jx zhejiang zj jilin jl respect result show manur input affect total abund arg receiv soil remark alter composit arg soil manur associ arg signific enrich manur amend soil includ gene confer resist sulfonamid aminoglycosid tetracyclin chloramphenicol trimethoprim fold varianc partit analysi show major varianc arg communiti explain mobil genet element bacteri profil concentr heavi metal antibiot furthermor arg subtyp identifi potenti extrins arg deriv manur jx zj jl soil respect includ share arg subtyp also found manur associ arg aada sul sul tetc tetg declin incub time jx zj soil wherea first decreas increas jl soil abund five arg jl soil signific higher jx zj soil collect find reveal soil type respons transmiss fate manur associ arg agroecosystem | D008372;D012987 | T167 |
36,252,511 | mechan mitig effect wheat germ peptid lead induc oxid damag pc cell well known lead induc neurotox close relat oxid stress accord previous report wheat germ peptid wgps isol wheat germ shown potent antioxid capac studi hypothes wgps could protect pc cell lead induc oxid stress protect efficaci wgps investig pc cell pretreat wgps h expos lead h antioxid capac assess cell viabil ros mda sod cat gr gpx gsh gssg experiment result show wgp wgp wgp could revers reduct cell viabil caus lead exposur lead exposur caus oxid stress increas level ros mda moreov decreas level sod cat gpx gr gshgssg could observ howev wgp wgp wgp protect pc cell lead induc oxid stress revers phenomena protein express txnip keap nrf character western blot result illustr lead exposur regul express txnip keap regul express nrf wgp wgp wgp could improv antioxid capac pc cell revers phenomenon therefor present studi demonstr wgp wgp wgp may protect lead induc oxid stress pc cell regul txnipkeapnrf pathway | D051267;D000975 | T123;T121;T116;T039;T044 |
36,252,499 | vaccarin improv insulin sensit glucos uptak diet induc obes mice via activ gpr pikaktglut pathway insulin resist risk factor type diabet often associ obes vaccarin flavonoid found vaccaria seed common use tradit chines medicin activ blood circul show vaccarin amelior high fat diet induc obes insulin resist mice reduc fat accumul improv insulin sensit white adipos tissu hyperinsulinem euglycem clamp test reveal enhanc glucos uptak vaccarin treat wat skelet muscl consist activ insulin signal pathway tissu mechanist vaccarin activ adipos tissu gpr subsequ activ pikaktglut signal pathway l cell togeth result reveal undiscov function vaccarin prevent obes relat insulin resist advoc vaccarin hold promis develop innov agent prevent metabol disord | D003924;D007333;D015398 | T047;T046;T044;T043 |
36,252,466 | type durat distract affect speed select crash risk evalu use naturalist drive data distract drive among lead caus roadway crash worldwid howev due limit polic report crash data often challeng understand natur magnitud problem distract also shown affect driver speed select import mean speed speed varianc substant impact crash risk studi util naturalist drive data investig relationship engag various secondari non drive task driver speed select differ drive context separ analys conduct low speed high speed drive environ two way random effect linear regress model estim speed regim control driver roadway traffic characterist differ assess base upon ten type secondari task general engag task found decreas speed high speed environ effect mix low speed set chang speed much pronounc secondari task includ combin visual manual cognit distract cell phone use among secondari task averag episod driver talk handheld cellphon associ mph speed reduct high speed environ mph increas low speed set addit examin impact speed select risk involv crash near crash event also evalu consider type durat distract interest distract tend show similar relationship direct magnitud risk involv crash near crash event polici standpoint studi provid motiv legisl program aim curb distract drive | D000071826;D000075782;D040421;D001334 | T055;T056;T073;T054 |
36,252,462 | acut exacerb antineutrophil cytoplasm antibodi associ interstiti lung diseas clinic featur risk factor acut exacerb ae life threaten clinic event occur clinic cours idiopath pulmonari fibrosi ipf sever studi report ae also occur interstiti lung diseas ild ipf howev incid clinic featur risk factor ae major caus death antineutrophil cytoplasm antibodi anca associ ild anca ild patient well establish | D019268;D054990;D017563 | T129;T047;T116 |
36,252,450 | femal reproduct microbiota mammal general accept mammalian vagina contain site specif microbiota play relev role genit reproduct health exist extra vagin microbiota femal reproduct tract ie follicular fluid oviduct endometrium placenta least matter controversi mani conclus field fail consid technic limit bias confound factor inher next generat sequenc ngs approach creat uncertainti field doubt subject set focus new research effort scientif practic connot femal reproduct health current art state limit gap knowledg femal reproduct tract microbiota particular microb extra vagin environ present review also discuss possibl relationship gut oral microbiota reproduct event | D005836;D064307 | T032;T022;T028;T023;T001 |
36,252,447 | differenti express three independ cam gene code ident protein potenti relev distinct mrna stabil differ codon usag ca sensor protein calmodulin cam major regul multipl cell function uniqu puzzl featur human far investig mammal presenc three distinct cam gene differ chromosom code ident protein case appar genet redund evolv could advantag mammalian organ well establish main focus human articl aim review exist literatur address gene nonetheless differ function clear three cam gene differenti express differ tissu develop respons differ stimuli factor includ environment condit shown hippocamp neuron differ mrnas cam gene may even local differ within cell regul cam gene express achiev varieti regulatori element present three gene includ differ promotorinsul element noncod region differ length sequenc well regul epigenet factor mirna hypothes predict differ mrna stabil translat effici due diverg codon usag could play addit regulatori role three gene differ mark use synonym codon calm predict produc relat stabl mrna may import transcript level low transient absent eg spermatogenesi contrast calm predict much shorter mrna half life may provid better tempor control cam level deciph under mechan respons complex may help understand uniqu multigen arrang may advantag optim spatio tempor express cam higher eukaryot final discuss express cam gene select human patholog mutat gene respons appear serious congenit syndrom main affect heart although less known possibl also affect function central nervous system organ | D002147;D020871 | T123;T116;T080;T045;T044 |
36,252,427 | regener infarct heart myocardi infarct respons inject hydrogel combin anti apoptosi anti inflammatori pro angiogenesi properti current treatment includ drug therapi medic devic implant organ transplant consider shortcom myocardi infarct mi high invas scarc number donor organ easi thrombosi immun reject poor therapeut effect therefor develop new solut repair infarct heart urgent need smart respons inject hydrogel serv good foundat biomed engin especi cardiac regener herein synthes inject hydrogel respond inflammatori microenviron site mi provid drug curcumin cur tailor recombin human collagen type iii rhcol iii control manner myocardi repair excel antioxid anti inflammatori properti cur could effect reduc ros level cell apoptosi inhibit inflammatori reaction mi tailor rhcol iii promot cell prolifer migrat angiogenesi therapeut hydrogel result rapid recoveri cardiac function mi elev express cardiac marker actinin cx vitro vivo data show combin anti apoptosi anti inflammatori pro angiogenesi treatment strategi auspici tactic treatment mi signific clinic applic valu furthermor work also demonstr great applic potenti tailor rhcol iii promot repair regener infarct heart | D020100;D009203 | T122;T047 |
36,252,409 | arsenosugar extract alga isol anion exchang solid phase extract obtain reliabl speciat data evalu dietari exposur increas understand arsenic biochemistri alga hinder avail suitabl standard arsenosugar major speci type sampl moreov chemic synthes compound report complex tedious aim work investig feasibl anion exchang spe cartridg sax wax easi quick altern isol preconcentr arsenosugar two commerci silica base spe cartridg strong anion exchang sorbent dsc sax weak anion exchang sorbent dsc nh compar spe three arsenosugar po sug sug sug effect ph ionic strength type salt elut solvent elut protocol arsenosugar studi elut solut spe analyz icp ms total arsenic content ic icp ms studi arsenic speciat develop spe procedur allow obtain solut contain three arsenosugar isol arsenic speci recoveri sug sug wherea po sug around | D001151 | T121;T196;T131 |
36,252,393 | impact landcov composit densiti local deer cull site chronic wast diseas preval chronic wast diseas cwd prion diseas cervida famili manag illinoi deer sinc first detect fall manag use state sponsor local focus cull lfc program implement close possibl previous identifi cwd infect locat trss townshiprangesect use hunter harvest lfc deer uniqu trss respect year surveil manag divid studi area group trss similar landcov type splt assess cwd hunter harvest preval lfc non lfc site landcov composit also evalu import month lfc implement determin whether densiti lfc site total number deer remov lfc predict hunter harvest cwd preval percentag cwd posit sampl hunter lower lfc sampl studi area splts probabl cwd increas splt group combin studi area area without lfc nearbi area prior lfc nearbi trs studi area low cwd odd hunter harvest deer found three splts two splts within trss non lfc five five splts within trss lfc result suggest import account landcov composit implement sustain manag habitat higher risk cwd find support hunter harvest alon control cwd critic need continu lfc intervent whole studi area regardless landcov composit lfc januari import decreas hunter harvest cwd preval lfc conduct march howev lfc conduct januari februari march equal import evalu month per habitat furthermor densiti lfc site proxim known infect area better predictor cwd number deer remov lfc suggest increas densiti lfc site greater impact cwd proxim lfc infect area help control cwd ultim landown hunter collabor cwd surveil manag program critic protect illinoi wild deer herd studi demonstr ongo valuabl contribut protect natur public resourc | D034081;D003670 | T047;T015 |
36,252,392 | odor associ memori necessarili high emot laboratori clinic studi shown odor tend evok high emot autobiograph memori frequent come earli period life one potenti explan effect memori associ odor particular emot anoth potenti explan presenc emot odor retriev lead particip impress retriev memori particular emot point near research odor evok autobiograph memori reli presenc odor cue memori procedur allow one distinguish whether emot memori due memori presenc current cue contrast current studi stimuli present retriev autobiograph memori instead ask peopl report memori specif associ five tradit differ sens ask inform autobiograph memori evok throughout day assess role sens experienc memori across three studi use slight differ methodolog found odor associ autobiograph memori emot older memori main associ modal result care put question notion odor associ autobiograph memori emot autobiograph memori most associ modal sinc differ present previous studi lie differ situat retriev result present evid toward retriev base explan | D009812;D061212 | T120;T070;T041 |
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