PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,252,043 | geometr program self limit assembl tubul use dna origami colloid self assembl one promis strategi make function materi nanoscal yet new design principl make self limit architectur rather spatial unlimit period lattic structur need address challeng explor tradeoff address assembl self close assembl specif class self limit structur cylindr tubul make triangular subunit use dna origami specif valenc limit interact design bind angl studi assembl tubul self limit width much larger size individu subunit simplest case tubul assembl singl compon geometr program dihedr angl neighbor subunit show tubul reach mani micromet length averag width prescrib dihedr angl find distribut width chiral tubul ration develop model consid finit bend rigid assembl structur well mechan self closur final demonstr distribut tubul sculpt increas number subunit speci therebi increas assembl complex demonstr use two subunit speci success reduc number avail end state half result help shed light role assembl complex geometri self limit assembl could extend self limit architectur shell toroid tripli period framework | D004247;D049329 | T123;T073;T114 |
36,252,042 | coexist divers communiti higher order interact central assumpt ecolog model interact communiti oper pair speci howev two speci may interact affect growth focal speci although interact among three speci call higher order interact potenti modifi theoret understand coexist ecologist lack clear expect interact shape communiti structur analyt predict numer confirm variabl strength higher order interact affect speci coexist found higher order interact strength becam variabl across speci fewer speci could coexist echo behavior pairwis model interspecif higher order interact becam harm relat self regul coexist divers communiti destabil coexist also lost interact weak mutualist higher order effect becam preval behavior depend function form interact destabil effect mutualist higher order interact amelior strength satur speci densiti last show speci rich communiti structur higher order interact lose speci readili speci poor counterpart general classic result communiti stabil work provid need theoret expect higher order interact impact speci coexist divers communiti | D017753;D008962 | T062;T070;T170;T082 |
36,252,041 | generic framework hierarch de novo protein design de novo protein design enabl explor novel sequenc structur absent natur protein univers de novo design also stand stringent test understand under physic principl protein fold may lead develop protein unmatch function characterist first fundament challeng de novo design devis design structur templat lead sequenc adopt predict fold built topobuild tb de novo design method automat assembl structur templat nativ like featur start string descriptor captur overal topolog protein framework elimin depend hand craft fold specif rule iter data driven approach extract geometr paramet structur tertiari motif evalu topobuild framework design sequenc set five protein fold experiment character reveal sever sequenc fold stabl solut topobuild de novo design framework broad use guid generat artifici protein custom geometri enabl explor protein univers | D017510;D011506 | T123;T116;T044 |
36,252,040 | endocytosi trigger v atpas syk mediat prime cgas activ innat immun respons current view nucleic acid mediat innat immun bind intracellular sensor nucleic acid suffici activ report endocytosi virus foreign dna initi prime signal dna sensor cyclic gmp amp synthas cgas mediat innat immun respons mechanist viral infect foreign dna transfect trigger recruit spleen tyrosin kinas syk cgas endosom vacuolar h pump v atpas syk activ phosphoryl human cgas mous cgas prime activ upon bind dna prime cgas initi robust cgamp product mediat irf activationstimul interferon gene depend innat immun respons consist block v atpas syk axi impair dna virus transfect dna induc cgamp product express antivir gene find reveal v atpas syk mediat tyrosin phosphoryl cgas follow endocytosi virus cargo serv prime signal cgas activ innat immun respons | D004705;D007113;D009713;D000072377;D025262 | T032;T126;T116;T043 |
36,252,039 | chemic timer approach delay chemiluminesc although onset time chemic reaction manipul mechan electr optic method chemic control remain high challeng herein report chemic timer approach manipul emiss onset time chemiluminesc cl reaction mixtur mn nahco luminol analog h produc reactiv oxygen speci ros radic superoxo speci superoxid contain complex high effici accompani strong immedi cl emiss surpris addit thiourea postpon cl emiss concentr depend manner delay attribut slow generat scaveng mechan found general applic various type cl reagent ros radic scaveng also popular chromogen reaction precis regul cl kinet util dynam chemic code improv code densiti secur approach provid power platform engin chemic reaction kinet use chemic timer applic potenti bioassay biosensor cl microscop imag microchip array chip informat | D049449;D008165 | T070;T130;T109 |
36,252,038 | target deliveri anti inflammatori corticosteroid lycg posit cell abat sever influenza symptom distribut lycg posit cell respons infect mous respiratori tract influenza virus follow noninvas time immuno positron emiss tomographi convert nanobodi recogn lyc lyg marker neutrophil myeloid cell well influenza hemagglutinin specif nanobodi zr label pegyl positron emiss tomographi pet imag agent pet imag show strong accumul imag agent lung infect mice immunohistochemistri influenza virus infect mice control mice inject biotinyl pegyl version lycg specif nanobodi show presenc abund lycg posit myeloid cell posit lycg bronchial epithelium influenza virus infect mice consist focal inflamm lung find correl well immuno pet result signal detect control mice shown pet accumul lycg specif nanobodi infect lung synthes conjug lycg specif nanobodi dexamethason enabl target deliveri immunosuppress corticosteroid site inflamm conjug reduc weight loss accompani infect equival amount free dexamethason without effect nanobodi drug conjug thus enabl deliveri drug particular cell type appropri anatom site avoid system exposur free dexamethason strategi minim undesir side effect much lower effect dose nanobodi dexamethason conjug abil select target inflammatori cell may find applic treatment infect immun mediat diseas | D007251;D061905 | T129;T047;T116 |
36,252,037 | socioeconom inequ molecular risk chronic diseas observ young adulthood mani common chronic diseas age negat associ socioeconom status ses studi examin whether inequ alreadi observ molecular underpin diseas mani becom preval data come nation longitudin studi adolesc adult health add health larg nation repres sampl us subject follow two decad begin adolesc transcriptom data mrna seq random subset young adult ses household origin young adulthood examin covari priori defin mrna base diseas signatur specif gene transcript identifi de novo ses composit young adulthood predict mani diseas signatur incom subject status analys highlight ses base inequ immun inflammatori ribosom metabol pathway sever play central role senesc mani gene also involv transcript translat divers signal mechan averag causal mediat effect model suggest bodi mass index play key role account relationship overal result reveal inequ molecular risk factor chronic diseas often decad diagnos suggest futur direct social signal transduct model trace social circumst regul human genom | D012923 | T098;T080 |
36,252,036 | dynam process hunger thirst common mesolimb neural ensembl nucleus accumben nac canon reward center regul feed drink known whether behavior mediat differ neuron employ two photon calcium imag awak behav mice found appetit phase hunger thirst sens near ident popul individu neuron nac respond monophas food cue fast anim water cue dehydr anim consummatori phase identifi three distinct neuron cluster tempor correl action initi consumpt cessat share feed drink dynam cluster also show near complet overlap individu neuron extens overlap among neuron modul neural activ reveal analog effect feed versus drink behavior aggreg data show high overlap set neuron nac detect food water reward elicit concord respons hunger thirst studi establish general role mesolimb pathway mediat instinct behavior control motiv associ variabl rather confer behavior specif | D006815;D013894 | T184;T039 |
36,252,035 | disrupt proteostasi caus ire mediat reprogram alveolar epitheli cell disrupt alveolar type cell aec protein qualiti control implic chronic lung diseas includ pulmonari fibrosi pf previous report vivo model clinic surfact protein c sp c mutat led aec endoplasm reticulum er stress spontan lung fibrosi provid proof concept disrupt proteostasi proxim driver pf use two clinic sp c mutat model discov aec experienc signific er stress lose quintessenti aec featur develop reprogram cell state heretofor seen respons lung injuri use singl cell rna sequenc vivo organoid base model show state aris de novo intrins aec dysfunct cell autonom aec reprogram attenu inhibit inositol requir enzym ire signal use ire inhibitor reduc develop reprogram cell state also diminish aec driven recruit granulocyt alveol lung injuri find identifi aec proteostasi specif ire signal major product xbp driver key aec phenotyp chang identifi lung fibrosi | D056809;D055370;D017346;D011658;D008565;D065150 | T123;T116;T025;T192;T062;T126;T037;T043;T047 |
36,252,034 | structur mechan actin atp hydrolysi major cytoskeleton protein actin undergo cyclic transit monomer g form filament f form drive organell transport cell motil mechan work driven atpas activ catalyt site f form deeper understand actin cellular function reaction mechan must elucid show singl actin molecul trap f form fragmin domain bind present crystal structur atp analog adp pi adp bound form resolut g f conform transit shift side chain gln reloc four water molecul includ w attack water w help water facilit hydrolysi appli quantum mechanicsmolecular mechan calcul structur reveal consist comprehens reaction path atp hydrolysi f form actin reaction path consist four step w w rotat p g b bond cleavag four concomit event w po format oh proton cleavag nucleophil attack oh p g abstract proton transfer proton reloc stabil adp pi bound f form actin mechan explain slow rate atp hydrolysi actin irrevers hydrolysi reaction catalyt strategi actin atp hydrolysi essenti motor protein like myosin process hydrolysi distinct discuss term pi releas f form destabil global conform chang | D000199;D011522 | T123;T196;T116 |
36,252,033 | identifi origin obsidian artifact deh luran plain southwestern iran highlight communiti connect neolith zagro exchang network creat neolith pastor transhum central explain distant transport obsidian sinc chemic analysi first use attribut near eastern artifact volcan origin sinc critic reassess floral faunal chronolog data upend long held interpret regard emerg food product demonstr far travel nomad pastoralist myth realiti least neolith despit debat regard propos convey mechan obsidian artifact transport receiv relat littl attent compar zooarchaeolog archaeobotan line investig rise nondestruct portabl instrument permit entir obsidian assemblag trace sourc renew signific elucid connect among earli pastor agricultur communiti share find obsidian artifact excav site ali kosh chagha sefid southern zagro obsidian artifact site destruct test remaind sort color result emphas dynam acceler connect among earli late neolith communiti propos support altern model obsidian distribut among settl communiti brief divers obsidian assemblag acceler diachron invis trend earlier studi model increas popul densiti support archaeolog data comput simul offer insight regard neolith demograph transit zagro equival common thought occur around world | D001106;D005898 | T090;T091;T073 |
36,252,032 | veloc postglaci migrat fire adapt boreal tree speci eastern north america earth climat warm rapid sinc begin industri era forc terrestri organ adapt migrat constitut one effect process surviv thrive although speed tree speci migrat function climat chang unknown one way predict latitudin movement tree climat twenti first centuri examin past migrat sinc last glacial maximum studi radiocarbon date macrofossil use calcul veloc past migrat jack pine pinus banksiana black spruce picea mariana two import fire adapt conif north american boreal forest jack pine migrat mean rate km per centuri km cent unglaci site central southeastern unit state northern limit speci subarct canada howev veloc increas unglaci earli deglaci site southern quebec slow earli mid holocen central eastern quebec migrat lowest speed late holocen time stop ago compar jack pine black spruce migrat faster mean rate km cent ice border last interstadi bllingallerd speci tree limit modern rang speci near occupi ago factor modul chang veloc jack pine migrat close associ warm dri climat late pleistocen holocen transit humid climat mid late holocen | D005390;D028222;D028223 | T002;T067 |
36,252,031 | calibr free high precis robust terahertz ultrafast metasurfac monitor gastric cancer optic sensor great potenti convert invis bioanalyt respons readabl inform envis power platform biolog analysi earli diagnosi diseas howev current extract sens data basic process via seri complic time consum calibr sampl refer inevit introduc extra measur error potenti annihil small intrins respons propos experiment demonstr calibr free sensor achiev high precis biosens detect base optic control terahertz thz ultrafast metasurfac photoexcit silicon bridg enabl reson frequenc shift thz reach maxim phase variat thz typic environment measur error complet elimin theori normal fourier transform transmiss spectra ultrashort time delay ps result extrem robust sens devic monitor cancer process gastric cell believ calibr free sensor high precis robust advantag extend implement studi ultrafast biolog dynam may inspir consider innov field medic devic nondestruct detect | D013274 | T191 |
36,252,030 | intracellular ca channel trpml pip effector regul autophagosom biogenesi autophagi multipl fusion event initi autophagosom format culmin fusion endo lysosom ca depend manner sourc ca molecular mechan ca provid process known intracellular ca permeabl channel transient receptor potenti mucolipin trpml local autophagosom interact mammalian autophagi relat protein atg homolog gate show lipid regul trpml ca releas channel phagophor provid ca necessari autophagi progress generat trpml gcamp fusion protein target report trpml compart local channel function notabl trpml gcamp local phagophor level increas respons nutrient starvat import phosphatidylinositol phosphat pip essenti lipid autophagosom format select regul trpml trpml interact pip direct activ trpml current ca releas phagophor promot increas autophagi inhibit trpml suppress autophagi even presenc excess pip activ trpml revers autophagi inhibit caus block pip moreov disrupt trpml pip interact abolish trpml activ pip increas autophagi taken togeth result reveal trpml downstream effector pip key regul autophagi activ trpml pip critic step provid ca phagophor fusion process essenti autophagosom biogenesi | D000071182;D001343 | T026;T043 |
36,252,029 | yellow polyketid pigment suppress prematur hatch social amoeba low molecular weight natur product microb indispens develop potent drug howev biolog role within ecolog context often remain elus shed light natur product eukaryot microorgan abil transit singl cell multicellular organ social amoeba eukaryot harbor larg number polyketid biosynthet gene genom yet virtual none correspond product isol character use complementari molecular biolog approach includ crispr cas generat polyketid synthas pks inactiv overproduct strain social amoeba dictyostelium discoideum differenti untarget metabolom wild type versus mutant fruit bodi allow us pinpoint candid metabolit deriv amoeb pks extrachromosom express respect gene led identif yellow polyunsatur fatti acid analysi temporospati product pattern compound conjunct detail bioactiv studi reveal polyketid spore germin suppressor | D000656;D001688;D004023;D061065 | T123;T121;T204;T109 |
36,252,028 | arabidopsi orpa mediat er autophagosom membran contact site regul pip plant autophagi autophagi intracellular degrad system cytoplasm constitu mediat format doubl membran organell term autophagosom subsequ fusion lysosomevacuol format autophagosom requir membran endoplasm reticulum er tight regul seri autophagi relat atg protein lipid howev er contact autophagosom regul autophagi remain elus plant studi identifi demonstr role arabidopsi oxysterol bind protein relat protein orpa mediat er autophagosom membran contact autophagosom biogenesi show orpa local er plasma membran contact site epcss autophagosom orpa interact er local vamp associ protein vap atg autophagosom mediat membran contact site mcss orpa artifici microrna knockdown kd plant seedl display retard growth impair autophagi level atga atg accumul associ er membran orpa kd line moreov orpa bind multipl phospholipid show coloc phosphatidylinositol phosphat pip vivo taken togeth orpa mediat er autophagosom mcss regul autophagi pip redistribut | D017360;D035683;D000072376 | T123;T109;T002;T114 |
36,252,027 | date emerg dairi first farmer central europ use c analysi fatti acid preserv potteri vessel direct accur precis date archaeolog potteri vessel achiev use recent develop approach base radiocarbon date purifi molecular compon food residu preserv wall potteri vessel method target fatti acid anim fat residu make uniqu suit direct date incept new food commod prehistor popul report larg scale applic method direct date introduct dairi central europ linearbandkeramik lbk cultur group base dairi fat residu radiocarbon date n th centuri bc western eastern expans lbk suggest dairi exploit arriv first settler respect region gradual adopt later particular signific contemporan lbk site show uneven distribut dairi exploit signific find demonstr power direct date introduct new food commod henc remov taphonom uncertainti assess indirect base associ cultur materi remain | D003612;D005227 | T123;T109;T092;T168;T057 |
36,252,026 | prostaglandin product select brain endotheli cell necessari suffici elicit fever fever known elicit prostaglandin e act brain origin remain disput show mice select delet prostaglandin synthesi brain endotheli cell neural cell myeloid cell abolish fever induc intraven administr lipopolysaccharid select rescu prostaglandin synthesi brain endotheli cell reinstat fever data demonstr prostaglandin product brain endotheli cell necessari suffici elicit fever | D015232;D042783;D005334 | T121;T184;T025;T109;T125 |
36,252,025 | interfer nuclear wavepacket pair proton transfer reaction quantum mechan revolution chemist understand molecular structur contrast kinet molecular reaction solut well describ classic statist theori reveal dynam chemic system transit quantum classic studi femtosecond proton transfer symmetr molecul two ident reactant site spatial apart reaction launch superposit two local basi state hypothes ensu motion electron nuclei proceed conceptu lockstep superposit probabl amplitud decoher collaps system product use ultrafast spectroscopi observ initi superposit state affect reaction kinet interfer mechan aid quantum dynam model propos evolut nuclear wavepacket manifest unusu intersit quantum correl reaction | D004583;D011522 | T081;T196 |
36,252,024 | inhibit ras driven signal tumorigenesi pan ras monobodi target switch iii pocket ras mutant major therapeut target oncolog efficaci direct inhibitor avail identif shallow pocket near switch ii region ras led develop small molecul drug target site inhibit kras gc kras gd discov region ras may target inhibit employ small synthet bind protein term monobodi strong propens bind function site target protein report pan ras monobodi term jam bound ras isoform nanomolar affin demonstr limit nucleotid state specif upon intracellular express jam potent inhibit signal mediat ras isoform reduc oncogen ras mediat tumorigenesi vivo nmr mutat analysi determin jam bound pocket switch ii similar target low affin small molecul inhibitor bi whose vivo efficaci demonstr furthermor jam direct compet raf rbd bi result provid direct valid target switch iii pocket inhibit ras driven tumorigenesi general result demonstr util tool biolog probe discov valid druggabl site challeng target | D001688;D016283 | T123;T121;T126;T116 |
36,252,023 | sleep facilit spatial memori navig use minecraft memori navig task sleep facilit hippocamp depend memori support acquisit mainten intern represent spatial relat within environ human howev find mix regard sleep contribut spatial memori navig may due task design outcom measur develop minecraft memori navig mmn task purpos disentangl spatial memori accuraci navig chang time studi sleep independ contribut mmn task particip learn locat object free explor open field computer environ test teleport random posit around environ requir navig rememb locat object studi develop valid four uniqu mmn environ goal equat baselin learn immedi test perform total particip administ train phase immedi test particip baselin perform equival across four environ support use mmn task studi particip train test immedi h later period sleep wake found metric accuraci object locat ie spatial memori maintain night sleep wake metric accuraci declin contrast spatial navig improv sleep wake delay find support role sleep retain precis spatial relationship within cognit map howev support specif role sleep navig | D065852;D065854 | T041 |
36,252,022 | origin carbon mud implic global climat carbon mud repres one import geochem archiv reconstruct ancient climat environment evolutionari chang rock record mud also repres major sink global carbon cycl yet remain consensus carbon mud form present stabl isotop trace element data carbon constitu bahama includ ooid coral foraminifera alga use geochem fingerprint demonstr carbon mud sourc abras mixtur combin macroscop grain instead invers bayesian mix model requir presenc addit aragonit sourc posit sourc repres direct seawat precipit use geolog geochem data show white unlik domin sourc precipit instead present model mud precipit bank margin explain geograph distribut clump isotop thermometri stabl isotop signatur carbon mud next address enigma mud ooid abund bahama yet rare rest world mediterranean outflow feed bahama alkalin water modern ocean th percentil high alkalin appear prerequisit nonskelet carbon factori mediterranean outflow reduc miocen bahamian carbon export ceas million year final show shut turn shallow carbon factori send rippl global climat system | D002254;D019015 | T121;T068;T070;T109 |
36,252,021 | neandert dietari conundrum insight provid tooth enamel zn isotop gabasa spain character neandert diet most reli nitrogen isotop analys bone tooth collagen howev nitrogen isotop data recov bone teeth iberia due poor collagen preserv paleolith site region zinc isotop shown reliabl method reconstruct trophic level absenc organ matter preserv present result zinc zn strontium sr carbon c oxygen isotop trace element ratio analysi measur dental enamel pleistocen food web gabasa spain character diet ecolog middl paleolith neandert individu base extrem low zn valu observ neandert tooth enamel result support interpret neandert carnivor alreadi suggest n isotop valu specimen region work could help identifi isotop peculiar lowest zn highest n food web due metabol andor dietari specif neandert | D002335;D059125;D014070;D014131 | T121;T123;T196;T015;T008;T023 |
36,252,020 | data driven topolog map approach priori predict stabl molecular crystallin hydrat predict structur stoichiometr fraction nonstoichiometr hydrat organ molecular crystal immens challeng due extens search space differ water content host molecular placement throughout crystal intern molecular conform howev dri framework hydrat especi nonstoichiometr isostructur dehydr often predict standard anhydr crystal structur predict csp protocol inspir develop field drug bind introduc effici data driven topolog awar approach predict organ molecular crystal hydrat structur map water posit within crystal structur method requir priori specif water content therefor predict stoichiometr fraction nonstoichiometr hydrat structur approach term map approach crystal hydrat mach establish set rule systemat determin favor posit water insert within predict experiment crystal structur base consider chemic featur local environ void region propos approach test hydrat three pharmaceut relev compound exhibit divers crystal pack motif void environ characterist hydrat structur overal show map approach introduc advanc effici perform hydrat csp generat stabl hydrat stoichiometri low cost consid integr compon csp workflow | D014867 | T121;T197 |
36,252,019 | climat chang nonlinear impact precipit anomali incom inequ climat anomali flood drought well gradual temperatur chang shown advers affect economi societi although studi find climat chang might increas global inequ widen dispar across countri effect within countri incom distribut littl investig role rainfal anomali show extrem level precipit exacerb within countri incom inequ strength direct effect depend agricultur intens economi high agricultur intens countri climat anomali negat impact agricultur sector lower incom bottom end distribut generat greater incom inequ result indic sd increas precipit averag valu time stronger impact bottom incom share countri high employ agricultur compar countri low employ agricultur sector project model futur precipit temperatur reveal high heterogen pattern global scale incom inequ worsen high agricultur intens economi particular africa find suggest rainfal anomali degre depend agricultur crucial factor assess negat impact climat chang bottom incom distribut | D000383;D057231 | T090;T070 |
36,252,018 | drive estrogen receptor loss via er induct gata inhibit breast cancer one fourth recurr estrogen receptor posit er breast cancer lose er express lead endocrin therapi failur howev mechan under er loss remain fulli explor show regul breast cancer drive convers er er epitheli mesenchym transit emt identifi er isoform er downstream effector overexpress induc er xenograft tumor spheroid regul support posit correl er express human breast cancer er antagon er inhibit er express isoform specif deplet er block er convers emt induc overexpress tumor spheroid thus establish er key mediat driven er loss emt er promot repress gata phosphoryl akt consensus bind site upon akt activ bind phosphoryl gata facilit degrad gata caus gata lose transcript control target gene er er also demonstr role collabor akt er induct endocrin therapi resist three dimension spheroid tamoxifen treatment model mcf td er breast cancer cell thus er regul provid previous unrecogn mechan er loss endocrin therapi failur | D001943;D047628;D050990;D048948 | T123;T191;T116;T192 |
36,252,017 | regul restructur mucin secretori granul matur vivo mucin larg high glycosyl transmembran secret protein line protect epitheli surfac howev detail mucin biosynthesi packag vivo larg unknown demonstr multipl distinct mucin undergo intragranular restructur secretori granul matur vivo form uniqu structur spatial segreg within granul identifi tempor regul gene influenc mucin restructur includ control ph vha ca ion fwe cl ion clic clc c final show alter mucin glycosyl influenc dimens structur therebi affect secretori granul morpholog studi elucid key step factor involv intragranular rather intergranular segreg mucin regul restructur event secretori granul matur understand multipl distinct mucin effici packag secret secretori granul may provid insight diseas result defect mucin secret | D009077;D022142 | T026;T123;T116 |
36,252,016 | ring fuse pyridon effect multidrug resist gram posit pathogen synergist standard care antibiot alarm rise multidrug resist gram posit bacteria precipit healthcar crisi necessit develop new antimicrobi therapi describ new class antibiot base ring fuse pyridon backbon activ vancomycin resist enterococci vre serious threat classifi center diseas control prevent multidrug resist gram posit bacteria ring fuse pyridon antibiot bacteriostat activ activ divid exponenti phase enterococc cell bactericid activ nondivid stationari phase enterococc cell molecular mechan drug induc kill stationari phase cell mimic aspect fratricid observ enterococc biofilm mediat atn autolysin gele proteas addit combin subleth concentr ring fuse pyridon standard care antibiot vancomycin found synerg kill clinic strain vre furthermor broad rang antibiot resist gram posit pathogen includ respons increas incid antibiot resist healthcar associ infect suscept new class pyridon antibiot given broad antibacteri activ ring fuse pyridon compound gram posit gmp bacteria term compound gmpcide hold promis combat rise tide antibiot resist gram posit pathogen | D006094;D011728;D065507 | T007;T109 |
36,252,014 | intracellular infect symbiot bacteria requir mitot kinas aurora subcellular event occur cell legum plant form transcellular symbiot infect structur compar occur premitot cell demonstr aurora kinas aur high conserv mitot regul requir intracellular infect rhizobia medicago truncatula aur interact microtubul associ protein tpxl map famili respect activ phosphoryl aur local within preinfect structur mybr rhizobia induc mitot transcript factor direct regul aur two close space mitosi specif activ cis element data consist model mybr aur regulatori modul serv proper orient preinfect structur direct transcellular deposit cell wall materi grow infect thread analog role cell plate format find indic eukaryot conserv mybr tpxl aur map mitot modul conscript support endosymbiot infect legum | D064127;D046913;D010940;D012231;D013559 | T007;T070;T116;T040;T126;T002 |
36,252,013 | oxid state specif fluoresc copper sensor reveal oncogen driven redox chang regul labil copper ii pool copper essenti metal nutrient life often reli redox cycl cu cu ii oxid state fulfil physiolog role alter cellular redox status lead imbal copper homeostasi contribut cancer metalloplasia metal depend diseas vulner copper respons fluoresc probe offer power tool studi labil copper pool reagent target cu limit method monitor cu ii owe potent fluoresc quench properti report activ base sens strategi turn oxid state specif detect cu ii metal direct acyl imidazol chemistri cu ii bind metal oxid state specif receptor accommod harder lewi acid cu ii relat cu activ pendant dye reaction proxim biolog nucleophil concomit metal ion releas thus avoid fluoresc quench copper direct acyl imidazol cu ii cd provid foundat inform exist regul labil cu ii pool includ identifi dival metal transport dmt cu ii import labil cu ii increas respons oxid stress induc deplet total glutathion level reciproc increas labil cu ii accompani decreas labil cu induc oncogen mutat promot oxid stress | D003300;D005456 | T123;T196;T121;T130 |
36,252,012 | ulcer coliti associ gene fut regul quantiti qualiti secret mucin mucin main macrocompon mucus layer protect digest tract pathogen fucosyl mucin increas mucus viscoelast resist shear stress properti alter patient ulcer coliti uc mark chronic inflamm distal part colon show level fucosyltransferas fut specif mucin increas distal inflam colon uc patient recapitul fut overexpress mucin produc ht n colon cell line increas deliveri muc plasma membran extracellular releas muc mucac mucin secret fut overexpress cell resist remov cell surfac mucin secret fut deplet cell fut kd fut kd caus intracellular accumul muc alter ratio secret muc mucac data fit well fut mice phenotyp protect uc fut mice exhibit thinner proxim colon mucus layer alter ratio neutral acid mucin togeth data reveal fut modifi biophys properti mucus control level cell surfac muc quantiti qualiti secret muc mucac suggest chang mucus viscoelast like facilit bacteri epitheli interact lead inflamm uc progress | D003093;D005647 | T047;T126;T116 |
36,252,011 | blast fungus zinc finger fold effector bind hydrophob pocket host exo protein modul immun recognit rice exocytosi play import role plant microb interact pathogenesi symbiosi exo protein integr compon exocyst octamer complex mediat tether vesicl membran eukaryot although plant exo known target pathogen effector underpin molecular mechan impact interact infect poor understood show molecular basi associ effector avr pii blast fungus maganaporth oryza rice exo allel osexof osexof sens immun receptor pair pii via integr rinnoi domain crystal structur avr pii complex osexof reveal effector bind conserv hydrophob pocket exo defin effectortarget bind interfac structur guid random mutagenesi valid import avr pii residu exo bind interfac sustain protein associ diseas resist rice challeng fungal strain express effector mutant furthermor structur avr pii defin zinc finger effector fold zif distinct max magnaporth avr toxb like fold previous describ major character oryza effector data suggest blast fungus zif effector bind conserv exo interfac manipul plant exocytosi effector also bait plant immun receptor point new opportun engin diseas resist | D020082;D012275 | T168;T004;T002 |
36,252,009 | altern regim shallow deep sea diversif explain speci rich paradox marin fish deep sea contain surpris divers life includ icon fish group anglerfish lanternfish still marin teleost fish speci restrict photic zone compris less ocean total volum macroevolutionari perspect paradox may explain three hypothes shallow water lineag time diversifi deep sea lineag shallow water lineag faster rate speciat deep sea lineag shallow deep sea transit rate limit deep sea rich use phylogenet compar method test among three non mutual exclus hypothes found support hypothes dispar speci rich better describ uneven outcom altern phase favor shallow deep diversif past million shallow marin teleost becam incred divers million ago period warm temperatur high sea level suggest import reef epicontinent set convers deep sea colon speciat favor brief episod cool temperatur increas effici ocean carbon pump final time variabl ecolog filter limit shallow deep colon much teleost histori help maintain higher shallow rich pelag lifestyl larg jaw associ earli deep sea colonist demers lifestyl taper bodi plan typic later colonist therefor also suggest hallmark characterist deep sea fish evolv prior colon deep sea | D005399;D014867 | T121;T197;T013 |
36,252,008 | role axon glial interact netrin g signal format low threshold mechanoreceptor end organ low threshold mechanoreceptor ltmrs cutan end organ convert light mechan forc act skin electr signal propag central nervous system mous hairi skin hair follicl associ longitudin lanceol complex end organ compris ltmr axon end intim associ termin schwann cell tsc process mediat ltmr respons hair deflect skin indent character development step lead format rapid adapt ra ltmr ltmr lanceol complex earli postnat develop ra ltmrs ltmrs extend prune cutan axon branch close associ nascent tsc process netrin g express develop ra ltmr ltmr lanceol end ntng ablat experi indic netrin g function sensori neuron promot lanceol end elabor around hair follicl netrin g ligand ngl encod lrrcc express tscs ablat lrrcc partial phenocopi lanceol complex deficit observ ntng mutant moreov ngl netrin g signal general mediat ltmr end organ format across divers tissu type demonstr fact ra ltmr end associ meissner corpuscl pacinian corpuscl also compromis ntng lrrcc mutant mice thus axon glia interact mediat part ngl netrin g signal promot ltmr end organ format | D001369;D008465 | T026;T023;T025 |
36,252,007 | neural event segment continu experi human infant infant experi world fundament understand cognit develop key principl adult experi despit receiv continu sensori input perceiv input discret event investig event segment infant differ adult research event cognit infant often use simplifi task adult experiment help solv segment problem infant defin event boundari present discret actionsvignett presuppos event experienc infant leav open question principl govern infant segment take differ data driven approach studi infant event segment continu input collect whole brain function mri fmri data awak infant adult comparison watch cartoon use hidden markov model identifi event state brain quantifi exist timescal organ multipl event represent across brain region adult brain exhibit known hierarch gradient event timescal shorter event earli visual region longer event later visual associ region contrast infant brain repres longer event even earli visual region timescal hierarchi boundari defin infant event partial overlap boundari defin adult brain activ behavior judgment find suggest event organ differ infant longer timescal stabl neural pattern even sensori region may indic greater tempor integr reduc tempor precis dynam naturalist percept | D001921;D008279 | T060;T023;T170;T059 |
36,252,006 | wettabl base ultrasensit detect amphiphil direct concentr disord region self assembl monolay various form ecolog monitor diseas diagnosi reli upon detect amphiphil includ lipid lipopolysaccharid lipoprotein ultralow concentr small droplet although assay base droplet wettabl provid promis option case relianc measur surfac bulk properti whole droplet eg contact angl surfac tension make difficult monitor trace amount amphiphil within small volum sampl report design principl self assembl monolay function microstructur surfac coat silicon oil creat local disord region within droplet contact line effect concentr amphiphil within area domin droplet static friction remark surfac enabl ultrasensit nake eye detect amphiphil chang droplet slide angl even concentr four five order magnitud critic micell concentr develop thermodynam model explain partit amphiphil contact line cooper associ within disord loos pack region self assembl monolay base local analyt concentr effect showcas laboratori chip surfac posit depend pin forc capabl detect industri biolog relev amphiphil eg bacteri endotoxin well sort aqueous droplet discret group base amphiphil concentr furthermor demonstr slide behavior amphiphil laden aqueous droplet provid insight amphiphil effect length therebi allow surfac discrimin analyt high dispar molecular size | D008823;D012827 | T122;T109 |
36,252,005 | loss graze larg mammalian herbivor destabil soil carbon pool graze mammalian herbivor climat mitig strategi influenc size stabil larg soil carbon soil c pool pg c world grassland stepp savanna continu declin number larg mammalian herbivor result loss grazer function consequenti soil c pool ultim global carbon cycl herbivor effect size soil c pool condit lead gain loss soil c becom increas clear effect equal import aspect stabil soil c remain unknown use replic long term field experi tran himalayan graze ecosystem evalu consequ herbivor exclus interannu fluctuat soil c interannu fluctuat soil c soil n higher herbivor exclus graze structur equat model suggest graze appear mediat stabil versus destabil influenc nitrogen n soil c may explain n addit stimul soil c loss absenc herbivor around world herbivor loss consequ declin grazer function therefor undermin stabil soil c soil c inert dynam pool provid natur base climat solut conserv restor function role larg mammalian herbivor extend stoichiometr coupl soil c soil n | D060434;D012987 | T040;T008;T167 |
36,252,004 | ubr target myosin heavi chain iib iix degrad molecular mechan essenti cancer induc muscl wast cancer cachexia lethal metabol syndrom featur muscl wast preferenti loss fast twitch muscl mass undefin mechan show cancer induc muscl wast select degrad myosin heavi chain mhc subtyp iib iix e ligas ubr mediat ubiquityl induct mhc loss atrophi cc myotub mous tibiali anterior ta murin cancer cell requir ubr regul cancer genet gain loss ubr function invers alter mhc level muscl mass ta tumor free mice ubr select interact ubiquityl mhc iib mhc iix substrat recognit catalyt domain respect cc myotub elev ubr muscl tumor bear free mice caus loss mhc iib mhc iix mhc mhc iia myofibrillar protein includ actin troponin tropomyosin tropomodulin muscl specif knockout ubr spare kpc tumor bear mice lose mhc iib mhc iix fast twitch muscl mass cross section area contractil forc rectus abdomini ra muscl patient cachexia prone cancer display select reduct mhc iix correl higher ubr level data suggest ubr regul mhc iibiix essenti cancer induc muscl wast therapeut intervent design block ubr regul cancer | D002100;D018995;D009369;D044767 | T184;T123;T116;T191;T126 |
36,252,003 | relat divers social portfolio predict well document link relat divers one social portfolio rich even relationship type across one social interact well across four distinct sampl respond unit state complet preregist survey n respond american time use survey n respond world health organ studi global age adult health n user french mobil applic n specif curv analys show posit relationship social portfolio divers well robust across differ metric well differ categor relationship type inclus wide rang covari peopl total amount social interact divers activ engag relat divers social portfolio uniqu predictor well individu within individu time | D011795 | T098;T062;T170;T081;T057 |
36,252,002 | sufu spop mediat regul gli essenti control mammalian cochlear hair cell differenti develop mammalian auditori epithelium organ corti requir precis control cell cycl withdraw differenti sensori progenitor prosensori cell cochlear apex exit cell cycl first differenti last sonic hedgehog shh signal requir spatiotempor regul prosensori cell differenti under mechan remain unclear show suppressor fuse sufu negat regul shh signal essenti control time progress hair cell hc differenti remov sufu lead abnorm atoh express sever delay hc differenti due elev gli mrna express later develop hc differenti defect restor sufu mutant action speckl type pdz protein spop promot gli protein degrad delet sufu spop result robust gli activ exacerb hc differenti defect demonstr gli inhibit hc differenti maintain progenitor state sox prosensori cell along basal apic axi develop cochlea sox express level higher progenitor cell differenti cell regul base apex differenti proceed dynam spatiotempor chang sox express level control shh signal gli togeth result reveal key function gli sustain progenitor state therebi prevent hc differenti turn govern basal apic progress hc differenti cochlea | D006198;D053823 | T123;T116;T025 |
36,252,001 | preval driver abrupt veget shift global dryland constant provis plant product integr support liabil ecosystem human wellb global dryland dryland paradigmat exampl system prone experienc abrupt chang function inde space time substitut approach suggest abrupt chang plant product widespread evid less clear use observ time seri experiment data larg scale studi preval import unknown driver abrupt rather gradual dynam pattern dryland may help unveil hotspot current futur dynam instabl dryland use global satellit deriv tempor assess dryland normal differ veget index ndvi show dryland ecosystem exhibit gain loss ndvi character abrupt positiveneg tempor dynam show abrupt chang common among negat posit ndvi trend found global region suffer recent drought particular around critic arid threshold posit abrupt dynam found ecosystem low season variabl high arid work unveil high import climat variabl trigger abrupt shift veget provid miss evid increas abrupt system intens manag human low soil organ carbon content around specif arid threshold result highlight abrupt chang dryland dynam common especi product loss pinpoint global hotspot dryland vulner identifi driver could target effect dryland manag | D017753;D012987 | T167;T070;T082 |
36,252,000 | transmembran protein tetraspanin cd sens membran curvatur multipl membran shape remodel process associ tetraspanin protein yet unknown mechan tetraspanin constitut famili protein four transmembran domain present everi cell type promin exampl tetraspanin cd requir fundament cellular process migrasom format fertil respect protein enrich curv membran structur cellular retract fiber oocyt microvilli factor drive enrich howev unknown reveal tetraspanin cd curvatur sensor prefer posit membran curvatur end use biomimet system emul membran cell retract fiber oocyt microvilli membran tube pull giant plasma membran vesicl control membran tension curvatur develop simpl thermodynam model partit curvatur sensor flat tubular membran allow us estim individu intrins curvatur two protein overal find illumin process migrasom format oocyt microvilli shape provid insight role tetraspanin protein membran remodel process | D009865;D059470 | T123;T116;T025 |
36,251,999 | differenti interact rest activ desensit state nicotin acetylcholin receptor lipid modul nicotin acetylcholin receptor pentamer ligand gate ion channel modul neuron excit larg allow ca permeat agonist bind promot transit rest state activ state rapid desensit state recent cryogen electron microscopi cryo em structur human receptor nanodisc report multipl conform select stabil inhibitori activ potenti compound howev function annot structur differenti interact unresolv lipid ligand remain incomplet character ion permeat membran interact ligand bind use comput electrophysiolog free energi calcul coars grain molecular dynam contrast nonconduct structur appar rest desensit state structur determin presenc potenti pnu consist activ state permeabl ca transit state associ compress rearrang membran particular vicin peripher mx helix intersubunit transmembran site implic select bind either pnu activ state cholesterol desensit state substanti function assign three lipid embed receptor structur ion permeat simul also propos testabl model state depend interact lipophil ligand includ mechan alloster modul transmembran subunit interfac | D058446;D011978 | T123;T116;T192 |
36,251,998 | determinist program human pluripot stem cell microglia facilit studi role health diseas microglia resid immun cell central nervous system cns deriv yolk sac macrophag popul develop cns earli embryon develop establish microglia popul self maintain throughout life local prolifer scalabl sourc microglia like cell mgls present forward program protocol generat human pluripot stem cell hpscs transient overexpress pu cebp hpscs led homogen popul matur microglia within mgls met microglia characterist morpholog transcript function level mgls facilit investig human tauopathi model cortic neuron microglia cocultur reveal secondari dystroph microglia phenotyp singl cell rna sequenc microglia integr hpsc deriv cortic brain organoid demonstr shift microglia signatur toward development vivo like phenotyp induc intercellular interact promot neurogenesi arbor taken togeth microglia forward program platform repres tool reductionist studi monocultur complex cocultur system includ brain organoid studi cellular interact healthi diseas environ | D017628;D039904 | T025 |
36,251,997 | neural represent geometri under shot concept learn understand neural basi remark human cognit capac learn novel concept one sensori experi constitut fundament problem propos simpl biolog plausibl mathemat tractabl comput power neural mechan shot learn naturalist concept posit concept learn exampl defin tight circumscrib manifold neural fire rate space higher order sensori area posit singl plastic downstream readout neuron learn discrimin new concept base exampl use simpl plastic rule demonstr comput power propos show achiev high shot learn accuraci natur visual concept use macaqu inferotempor cortex represent deep neural network dnn model represent even learn novel visual concept specifi linguist descriptor moreov develop mathemat theori shot learn link neurophysiolog predict behavior outcom delin sever fundament measur geometr properti neural represent accur predict shot learn perform naturalist concept across numer simul theori reveal instanc high dimension manifold enhanc abil learn new concept exampl intrigu observ strike mismatch geometri manifold primat visual pathway train dnns discuss testabl predict theori psychophys neurophysiolog experi | D003210;D016571 | T170;T041 |
36,251,996 | phenomenolog dynam competit ecosystem beyond nich neutral regim structur composit stabil ecolog popul shape inter intraspeci interact within communiti remain fulli understood interplay interact factor immigr control structur divers long term stabil ecolog system presenc nois fluctuat address problem use minim model interact multispeci ecolog communiti incorpor competit immigr demograph nois find complet phase diagram exhibit rich behavior multipl regim go beyond classic nich neutral regim extend modifi rare biospher nich like dichotomi particular observ regim character either nich neutral multimod speci abund distribut observ character transit differ regim show aris under kinet speci turnov extinct invas model serv minim null model noisi competit ecolog system complex model includ factor mutat environment nois compar | D017753;D008954 | T075;T070;T082 |
36,251,995 | femv cathepsin depend uniqu morbillivirus infect kidney domest cat felin morbillivirus femv recent discov pathogen domest cat classifi morbillivirus paramyxovirus famili determin complet sequenc femv us direct femv posit urin sampl without virus isol cell passag sequenc analysi viral genom reveal potenti diverg characterist archetyp morbillivirus first virus lack canon polybas furin cleavag signal fusion f glycoprotein second conserv amino acid hemagglutinin h glycoprotein use morbillivirus bind andor fusion activ cellular receptor cd signal lymphocyt activ molecul slam f absent show despit sequenc diverg femv h glycoprotein use felin cd receptor use human cd demonstr proteas respons cleav femv f glycoprotein cathepsin make femv uniqu morbillivirus similar close relat zoonot nipah hendra virus develop revers genet system femv us generat recombin virus express venus fluoresc protein addit transcript unit locat either phospho protein p matrix gene h larg l gene genom use recombin femv establish natur infect demonstr femv caus acut morbillivirus like diseas cat virus shed urin detect kidney later time point open door long term studi address postul role morbillivirus develop chronic kidney diseas | D018103;D018185 | T005;T047 |
36,251,994 | cop gata axi suppress ar signal prostat cancer androgen receptor ar signal crucial drive prostat cancer pca diagnos second lead caus death male patient cancer unit state androgen depriv therapi initi effect instanc ar posit advanc metastat pca howev patient inevit develop lethal castrat resist pca crpc also resist next generat ar signal inhibitor crpcs maintain ar express block ar signal remain main therapeut approach gata pioneer transcript factor emerg key therapeut target pca promot ar express activ direct inhibit gata transcript activ remain challeng enhanc gata degrad plausibl therapeut strategi gata protein stabil regul pca remain unknown show constitut photomorphogenesi protein cop e ubiquitin ligas drive gata ubiquitin kk degrad gata lack conserv de x xxvp de degron use altern brbr motif bind cop promot gata degrad cop inhibit ar express activ repress pca cell xenograft growth castrat resist accord gata overexpress cop mutat disrupt cop gata bind block cop tumor suppress activ conclud gata major cop substrat pca cop promot gata degrad direct mechan regul ar express activ pca growth castrat resist | D050989;D011471;D064129;D044767 | T123;T191;T126;T116 |
36,251,993 | covid climat chang finit pool worri twitter discuss climat chang mitig one world salient issu past three decad howev global polici attent partial divert address covid pandem past explor impact pandem frequenc content climat chang discuss twitter period consist finit pool worri hypothesi annual level daili basi larger number covid case death associ smaller number climat chang tweet climat chang discuss twitter decreas despit larger twitter daili activ usag greater coverag climat chang tradit media larger number north atlant ocean hurrican larger wildland fire area unit state evid support finit pool worri signific relationship daili covid casesdeath one hand public sentiment emot content climat chang tweet particular increas covid number decreas negat sentiment climat chang tweet emot relat worri anxieti fear anger | D000086382;D061108 | T047;T170;T067 |
36,251,992 | cryo em structur light harvest complex rhodopseudomona palustri reveal molecular origin absorpt tune genom purpl photosynthet bacteria contain multigen puc famili encod seri polypeptid togeth form heterogen antenna light harvest lh complex unravel complex generat four set puc delet mutant rhodopseudomona palustri encod singl type pucba gene pair enabl purif complex design puca lh pucb lh pucd lh puce lh structur four purifi lh complex determin cryogen electron microscopi cryo em resolut rang uniqu complex contain hitherto unknown polypeptid form extend undul ribbon lie plane membran enclos six nine lh subunit subunit locat near cytoplasm side complex break c symmetri lh complex bind six extra bacteriochlorophyl bchls enhanc nm absorpt complex structur show four complex two complet ring bchls confer absorpt band center nm puca lh pucb lh puce lh complex unusu pucd lh antenna singl strong near infar nir absorpt peak nm comparison cryo em structur lh complex reveal alter pattern hydrogen bond lh side chain bacteriochlorin ring emphas major role h bond play spectral tune bacteri antenna complex | D001429;D012241 | T123;T007;T109 |
36,251,991 | site site cross talk ost b glycosyl hceacam igv n glycosyl common posttransl modif secret protein eukaryot modif target asparagin residu within consensus sequenc n x st sequenc requir glycosyl initi transfer high mannos glycan oligosaccharyl transferas b ost ost b lead incomplet occup given site factor determin extent transfer well understood understand may provid insight function import enzym use mass spectrometri ms simultan measur relat occup three n glycosyl site n termin igv domain recombin glycoprotein hceacam demonstr addit primarili ost b enzym propos kinet model ost b n glycosyl fit kinet model ms data yield distinct rate glycan addit site suggest larg stochast initi order glycan addit model also suggest glycosyl one site influenc effici subsequ modif site glycosyl central n termin site lead dead end product seldom lead full glycosyl three site one path progress glycosyl one initi glycosyl c termin site effici lead full occup three site thus hceacam domain provid effect model system studi site specif recognit glycosyl sequon ost b suggest order effici posttransl glycosyl influenc steric cross talk adjoin acceptor site | D001216;D006602 | T123;T126;T116 |
36,251,990 | aesthet experi enhanc first person spatial represent episod autobiograph memori character spatial context affect compon affect spatial aspect interact affect modul way encod spatial context event investig one element affect name aesthet like modul memori locat three onlin experi n particip visit profession curat virtual art exhibit reloc previous view artwork museum map report much like across experi like artwork associ increas abil recal wall hung effect explain view time appear modul recognit speed like wall memori effect remain particip attend abstract rather like test occur h museum visit like also modul memori room work art hung effect primarili involv reduc room memori dislik artwork like wall memori effect remain control effect room memori recal wall requir recal one face direct find suggest posit aesthet experi enhanc first person spatial represent general first person compon posit affect transfer wider spatial represent facilit encod locat subject center refer frame affect spatial represent therefor import link element sentienc subject memori aesthet experi also spatial memori encount work art linkag may implic museum design | D061212 | T041 |
36,251,989 | trim microtubul regul act pantrop viral inhibitor screen combin function evolutionari analys identifi tripartit motif protein trim poor studi member trim famili negat regul hiv infect interferon ifn stimul myeloid cell trim inhibit earli phase infect hiv also hiv siv mac addit negat posit strand rna virus vesicular stomat virus sever acut respiratori syndrom coronavirus magnitud depend combin cell type virus mechanist trim associ direct microtubul antivir activ link abil promot accumul stabl microtubul program uncov integr part antivir ifn respons myeloid cell overal studi identifi trim antivir innat defens factor regul properti microtubul limit viral spread highlight cytoskeleton unappreci battleground host pathogen interact underli viral infect | D000070584;D044767;D014779;D015658 | T123;T116;T126;T043;T047 |
36,251,988 | paradox self sustain dynam emerg orchestr excitatori inhibitori homeostat plastic rule self sustain neural activ maintain local recurr connect fundament import cortic function converg theoret experiment evid indic cortic circuit generat self sustain dynam oper inhibit stabil regim theoret work establish four set weight wee wei wie wii must obey specif relationship produc inhibit stabil dynam known brain appropri set valu four weight class unsupervis manner inhibit stabil regim prove standard homeostat plastic rule general unabl generat inhibit stabil dynam instabl caus signatur properti inhibit stabil network paradox effect contrast show famili cross homeostat rule overcom paradox effect robust lead emerg stabl dynam work provid model begin silent network self sustain inhibit stabil dynam emerg learn rule govern four synapt weight class orchestr manner | D009415;D009473 | T023;T043;T042 |
36,251,987 | promot data qualiti reus archaeolog collabor identifi practic invest data manag infrastructur often seek catalyz new research outcom base reus research data achiev goal invest need better understand data creation data qualiti concern shape potenti reus data primari audienc paper center scientif domain specialist creat use dataset document archaeolog materi paper discuss practic promot data qualiti support open end reus data beyond immedi need creator argu identifi practic play key poor recogn role promot data qualiti reusabl use specif archaeolog exampl demonstr use global uniqu persist identifi communic aspect context avoid error misinterpret facilit integr reus discuss respons data creator data reuser employ identifi better maintain contextu integr data includ profession social ethic dimens | D001106;D000068598 | T090;T091;T080 |
36,251,983 | effect citrullin malat supplement muscl function bioenerget short term repeat bout fatigu exercis citrullin malat cm shown improv muscl perform healthi particip singl exercis session yet within framework exercis repeat close time interv consequ cm ingest mechan perform controversi bioenerget side remain undocu aim doubl blind placebo control studi evalu vivo effect short term dose h oral administr cm upon gastrocnemius muscl function bioenerget use non invas multimod nmr techniqu healthi rat experiment protocol consist two min bout fatigu exercis space min recoveri period cm treatment affect basal bioenerget status increas half fatigu time first exercis bout exercis repetit prevent pcr cost alter decreas glycolyt atp product contractil atp cost work muscl chang associ improv mechan perform addit cm influenc replenish high energi phosphoryl compound post exercis recoveri period therefor short term cm administr enhanc muscl bioenerget throughout fatigu bout exercis repeat close time interv enhanc benefit mechan perform | D018763;D002956 | T033;T123;T121;T116 |
36,251,982 | relationship practic environ variabl nurs manag percept workplac mistreat identifi factor amen chang examin relationship practic environ factor nurs manag nm percept workplac mistreat wpm | D009718;D058445;D000075282 | T054;T097;T048 |
36,251,981 | lanc label free live apoptot necrot cell explor use convolut neural network imag analysi identifi quantifi cell death basi cell death research current method obtain quantit measur reli establish biomark yet marker base approach suffer limit marker specif high cost reagent lengthi sampl prepar fluoresc imag base morpholog differ develop live apoptot necrot cell explor lanc categor cell death status label free manner incorpor machin learn imag process lanc workflow includ crop individu cell microscop imag hundr cell format imag databas around event train valid convolut neural network model use multipl cell line treatment condit lanc precis categor live apoptot necrot cell high accuraci import nondestruct label free lanc method allow track time dynam cell death process enhanc understand subtl cell death regul molecular level henc lanc fast low cost nondestruct label free method distinguish cell status appli cell death studi well mani biomed applic | D007091;D016571 | T170;T066 |
36,251,974 | immunohistochem express von willebrand factor potenti tool predict kidney allograft outcom report assess endotheli activ biomark kidney allograft biopsi use immunohistochemistri retrospect cohort studi evalu associ posttranspl outcom immunohistochemistri express caveolin von willebrand factor vwf cadherin caus biopsi diagnos interstiti fibrosi tubular atrophi unknown etiolog sampl antibodi mediat chang exclud patient follow year biopsi graft lossdeath seventi one sampl patient includ eighteen patient lost graft main due chronic reject caveolin cadherin associ graft loss vwf good accuraci predict graft failur auc ci p presenc vwf posit microvasculatur vwf associ reduc death censor graft surviv vs p result also observ subgroup present mild interstiti fibrosi ci vs p multivari analysi show vwf independ risk factor graft loss hr ci p conclus vwf might addit tool predict allograft outcom kidney transplant recipi interstiti fibrosi tubular atrophi unknown etiolog probabl reflect immun endotheli activ | D016030;D007674 | T061;T047 |
36,251,973 | use deep learn predict final status invas breast cancer equivoc immunohistochemistri invas breast carcinoma routin test use immunohistochemistri ihc reflex situ hybrid ish score equivoc ish test expens time consum univers avail studi train deep learn algorithm direct predict gene amplif status ihc slide data includ consecut case invas breast carcinoma score ihc follow ish test extern valid data set creat ihc slide prepar outsid institut intern ihc slide digit divid train test set fold cross valid small patch pixel random extract use train convolut neural network efficientnet b architectur use transfer learn approach predict slide test set made individu patch predict aggreg generat overal predict slide result receiv oper characterist area curv overal accuraci sensit specif analysi extern valid slide result receiv oper characterist area curv overal accuraci sensit specif although sensit specif high enough negat need reflex ish test entir approach may use triag case like posit initi treatment plan center ish test readili avail | D001943;D000077321 | T191;T066 |
36,251,972 | p pirh lcam promis prognost biomark endometri carcinoma immunohistochem genet studi endometri cancer ec common gynecolog cancer current method predict prognosi treatment respons unfortun suboptim studi evalu prognost valu p pirh lcam case ec use immunohistochemistri ihc polymeras chain reaction tp missens mutat result nuclear accumul p protein detect overexpress ihc form diffus strong nuclear posit involv least least tumor cell whole tumor cell discret geograph area abnorm p ihc express express case signific associ tumor grade myometri invas mi lymphovascular invas lvsi nodal metastasi figo stage advanc european societi medic oncolog esmo risk group p high ihc pirh express note case signific associ mi lvsi nodal metastasi figo stage high risk group p p p p p respect signific upregul pirh mrna express ec specimen compar control adjac tissu p upregul pirh mrna express signific associ pirh immunostain tumor grade tumor stage mi lymph node involv lvsi relaps p posit lcam immunoexpress note signific associ grade mi lvsi nodal metastasi figo stage high risk group p p p p p p respect analysi follow period reveal ec abnorm p ihc express high pirh posit lcam express exhibit potent relat tumor relaps shorter overal surviv diseas specif surviv p mutant p high pirh lcam posit ec high aggress tumor shorten surviv rate dismal outcom high risk relaps standard protocol therapi | D039842;D016889 | T123;T191;T116 |
36,251,967 | creat advanc practic regist nurs council within region hospit network articl describ develop advanc practic rn aprn council larg hospit network despit obstacl council abl demonstr posit outcom includ standard credenti onboard process product network aprn orient educ fair council abl guid workplac cultur establish support vertic horizont interprofession relationship provid recommend relev leadership board develop standard procedur | D057179;D009726 | T091;T097 |
36,251,963 | mesenter ischemia patient coronavirus scope review background coronavirus covid system diseas associ sever gastrointestin complic includ life threaten mesenter ischemia sought review summar current avail literatur present manag outcom mesenter ischemia patient covid patient method pubm databas search identifi studi publish januari januari report one adult year patient covid develop mesenter ischemia hospit demograph characterist clinic imag find manag outcom patient studi extract summar result total articl report patient covid mesenter ischemia met elig includ studi mean age year patient male imag find patient includ mesenter arteri venous thromboembol follow sign mesenter ischemia sixti seven percent patient taken oper room exploratori laparotomi bowel resect manag conserv termin ileum common involv area necrosi mortal rate patient covid mesenter ischemia common caus death multiorgan failur refractori septic shock twenti seven percent patient manag oper die post oper period conclus mesenter ischemia patient covid devast complic associ high rate morbid mortal effort focus develop strategi earli recognit manag | D065666;D000086382;D013505 | T061;T047;T046;T067 |
36,251,959 | high spin ground state aminyl trirad toward high spin oligo aza nanographen report high spin aminyl trirad near planar triphenylen backbon near planar fuse aminyl radic triphenylen ferromagnet coupl unit fcu magnet equival three fuse biphenyl fcus assur effect p p overlap within cross conjug system lead quartet ground state well separ low spin excit doublet state thermal popul low spin excit state detect squid magnetometri electron paramagnet reson epr spectroscopi provid doublet quartet energi gap e dq correspond popul quartet ground state room temperatur notabl epr base determin e dq reli direct detect quartet ground state doublet excit state e dq valu kcal mol steric shield trirad larger valu half life steric shield trirad methyltetrahydrofuran methf h room temperatur less steric shield trirad methf decompos k half life h k half life still h domin product decay trirad correspond triamin suggest hydrogen atom abstract solvent primari mechan studi expand frontier open shell pahsnanographen uniqu electron nonlinear optic magnet properti could use develop novel organ electron photon spintron | D008280;D006859 | T090;T196 |
36,251,958 | prolong therapi associ delay identif recurr intra abdomin infect background studi optim periton infect therapi stop trial identifi associ prolong antibiot therapi delay identif recurr intra abdomin infect iai howev associ observ studi purpos studi evalu associ recurr iai durat antibiot agent patient method adult patient underw sourc control procedur colon relat complic iai identifi patient meet inclus criteria exclud demograph comorbid post oper antibiot durat presenc secondari intra abdomin infect record primari outcom time identif secondari iai delay identif recurr infect identifi day follow sourc control procedur statist analysi use fisher exact wilcoxon rank sum use appropri result seventi six patient identifi met inclus criteria patient recurr iai patient recurr infect slight younger vs year p lower rate pre oper anticoagul vs differ initi length antibiot therapi sourc control recurr infect non recurr group p differ total day antibiot use two group recurr infect group averag day antibiot use non recurr group p patient recurr differ median day identif vs day p rate delay identif recurr infect vs p conclus similar stop trial fail identifi associ durat post oper antibiot agent recurr infect howev fail identifi associ prolong post oper cours time identif recurr infect evalu need determin prolong therapi delay identif recurr infect | D059413;D060085 | T047 |
36,251,956 | bring eyelid surgeri line intern guidelin regard peri oper antibiot agent pilot studi background intern guidelin advis prophylact antimicrobi agent primarili close surgic incis oculoplast surgeon report use chloramphenicol ointment evalu baselin surgic site infect ssi rate patient undergo eyelid surgeri receiv prophylact chloramphenicol ointment post oper withdraw prophylaxi prospect audit establish whether infect rate chang clinic meaning way articl report earli find patient method singl center retrospect audit undertaken electron medic record review consecut patient underw eyelid surgeri primari incis closur patient receiv post oper prophylact chloramphenicol histopatholog evid malign exclud patient demograph surgic detail evid post oper ssi complic record local polici chang accord nation guidelin prophylact chloramphenicol ointment withheld inform collect prospect polici exclud skin malign full thick skin graft patient system immunosuppress diabet mellitus potenti increas infect risk result statist signific differ group except senior surgeon surgic site infect identifi eye receiv post oper chloramphenicol three eye without antibiot agent statist signific conclus post oper ssi rate eyelid surgeri low routin use prophylact antibiot agent primarili close surgic eyelid incis adher intern standard may contribut antimicrobi resist earli result suggest infect rate remain low without prophylact chloramphenicol clinician consid withdraw routin practic suitabl patient | D019072;D013530 | T061;T046 |
36,251,949 | larotrectinib induc autophag cell death ampkmtor signal colon cancer larotrectinib lar high select potent small molecul inhibitor use patient tropomyosin receptor kinas trk fusion posit cancer includ colon cancer howev under molecular mechan specif patient colon cancer yet explor data show lar signific suppress prolifer migrat colon cancer cell addit lar suppress epitheli mesenchym transit emt process evidenc elev e cadherin e cad downregul vimentin matrix metalloproteinas mmp express furthermor lar found activ autophag flux lar increas ratio lciilci decreas express p colon cancer cell import lar also increas ampk phosphoryl suppress mtor phosphoryl colon cancer cell howev silenc ampk colon cancer cell lar induc accumul autolysom well lar induc suppress emt process signific diminish vivo assay also confirm tumour volum weight decreas lar treat mice control mice taken togeth studi suggest lar signific suppress colon cancer prolifer migrat activ ampkmtor mediat autophag cell death | D000080549;D003110 | T191;T043 |
36,251,948 | engin signal transduct cdte cdse quantum dot situ ratiometr photoelectrochem immunoassay cryab protein control modul respons mode extrem attract fabric biosensor programm analyt perform report proof concept ratiometr photoelectrochem pec immunoassay cryab protein base signal transduct regul sens interfac sandwich type pec structur design gold nanorod sensit quantum dot fix primari antibodi au nrsqds ab methylen blue sensit qds combin second antibodi mbqds ab serv photoelectr substrat signal amplifi respect unlik common recognit element sandwich type pec structur allow situ generat two specif respons signal analysi cryab captur au nrsqds ab led decreas photocurr cryab subsequ anchor mbqds ab produc anoth photocurr mb noteworthi take advantag differ energi band gap qds vari locat cdte cdse qds could realiz differ signal transduct strategi ie mode mode investig data analysi cryab mb via differ rout demonstr superior analyt perform ratiometri mode consequ ratiometr pec immunosensor offer linear rang ng ml detect limit pg ml work provid effici strategi situ collect multipl photocurr design ratiometr pec sensor | D045663;D019187;D015374;D018036 | T197;T059;T073;T075 |
36,251,935 | triclosan promot conjug transfer antibiot resist gene opportunist pathogen environment microbiom although triclosan wide use antisept chemic known promot transmiss antibiot resist divers host pure cultur still unclear whether triclosan could affect transmiss broad host rang plasmid among complex microbi communiti bacteri cultur fluoresc base cell sort high throughput rrna gene amplicon sequenc combin investig contribut triclosan transfer rate rang incp type plasmid proteobacteri donor activ sludg microbiom result demonstr triclosan signific enhanc conjug transfer rp plasmid among activ sludg communiti environment relev concentr high throughput rrna gene sequenc sort transconjug demonstr triclosan promot intergenera transfer also intragenera transfer rp plasmid among activ sludg communiti moreov triclosan mediat transfer rp plasmid opportunist human pathogen exampl legionella spp mechan triclosan mediat conjug transfer primarili associ excess oxid stress follow increas membran permeabl provok sos respons find offer insight impact triclosan dissemin antibiot resist aquat environment microbiom | D064307;D014260 | T121;T032;T109;T028;T001 |
36,251,912 | deep cnn framework neural drive estim hd emg across contract intens joint angl previous studi demonstr promis result estim neural drive muscl net output motoneuron innerv muscl use high densiti electromyographi hd emg purpos interfac assist technolog despit high estim accuraci current method base neural network need train specif motor unit action potenti muap shape updat condit ie vari muscl contract intens joint angl preliminari step dramat limit potenti general algorithm across task propos novel approach estim neural drive use deep convolut neural network cnn identifi cumul spike train cst general featur muap pool motor unit | D007537;D016571 | T170;T042 |
36,251,885 | photobiomodul pain control diseas oral caviti overview evid map implement integr complementari medicin object assess evid avail knowledg gap photobiomodul pbm oral facial pain background data effect identif noninvas resourc oral facial pain pbm may mitig risk invas therapeut resourc method nine electron databas search systemat review report oral facial pain outcom pbm ie intern initi impact evalu evid gap map methodolog tableau use graphic display paramet analyz research result sever wavelength within rang infrar use studi accompani red rang qualiti effect posit studi wherea impact degre low accord measur tool use assess systemat review amstar conclus despit posit potenti pbm treatment control pain diseas oral caviti complet inform dosimetri publish studi pbm still lack make difficult reproduc result found | D028022;D000529 | T061;T091 |
36,251,882 | widespread gene express diverg butterfli sensori tissu play fundament role reproduct isol speciat neotrop heliconius butterfli well known intric behavior multipl instanc incipi speciat chemosens play fundament role life histori group butterfli establish reproduct isol howev chemic communic involv synergist sensori accessori function remain challeng investig molecular mechan under behavior differ examin gene express profil genom diverg three sensori tissu antenna leg mouthpart sex femal male life stage differ adult stage two hybrid butterfli heliconius melpomen heliconius cydno integr compar transcriptom popul genom approach found evid widespread gene express diverg support crucial role sensori tissu establish speci barrier also show sensori diversif increas manner consist evolutionari diverg base comparison distant relat speci heliconius charithonia find studi strong support uniqu chemosensori function antenna three speci import z chromosom interspecif diverg nonneglig role nonchemosensori gene diverg chemosensori tissu collect result provid genom wide illustr diversif chemosensori system incomplet reproduct isol reveal strong molecular separ earli stage speciat provid uniqu perspect relev view genet architectur sensori accessori function chemosens beyond classic chemosensori gene famili lead better understand magnitud complex molecular chang sensori tissu contribut establish reproduct isol speciat | D002080 | T204 |
36,251,879 | estrogen receptor beta potenti therapeut target femal tripl negat breast cancer tripl negat breast cancer tnbc aggress subtyp breast cancer character absenc estrogen receptor alpha progesteron receptor receptor often serv target breast cancer treatment result tnbcs difficult treat high propens metastas distant organ reason tnbcs respons breast cancer mortal account breast cancer case howev estrogen receptor beta er isoform esr gene emerg potenti therapeut target treatment tnbcs use vivo xenograft preclin mous model human tnbc found express er signific reduc primari tumor growth metastasi moreov tnbcs elev level er show reduct epitheli mesenchym transit marker breast cancer stem cell marker increas express gene associ inhibit cancer cell invas metastasi suggest possibl mechan under antitumor activ er gene express analysi quantit polymeras chain reaction rna seq reveal treatment chloroindazol er select agonist ligand often enhanc suppress activ er tnbcs vivo tnbc cell cultur suggest potenti util er er ligand improv tnbc treatment find enabl understand mechan er imped tnbc growth invas metastasi consider way treatment involv er might improv tnbc patient outcom | D047629;D064726 | T191;T116;T192 |
36,251,869 | lithium enol lithium alkyn interact enantioselect construct quaternari carbon center concis synthesi goniomitin report method direct enantioselect alkyl alkyno alkendio acid form quaternari stereogen center applic method total enantioselect synthesi complex alkaloid goniomitin method effect alkyl alkyno acid alkendio acid substrat broad rang heterocycl function alkyl group substitu accompani crystallograph studi provid mechanist insight structur well defin chiral aggreg highlight cation interact lithium alkyn group | D008094;D000480 | T121;T196;T109 |
36,251,862 | pattern popul structur introgress among recent differenti drosophila melanogast popul despit centuri genet analysi evolutionari process generat pattern except genet phenotyp variat model organ drosophila melanogast remain poor understood particular genet variat partit within putat ancestr rang southern africa remain unresolv studi pattern popul genet structur admixtur spatial structur candid incompat allel across global sampl includ new access predomin remot region southern africa identifi nine major ancestri six primarili occur africa one previous describ find evid contemporari histor admixtur ancestri admixtur rate vari within contin exampl previous work highlight admixtur zone broad defin african european ancestri caribbean southeastern usa identifi west african ancestri like african contributor moreov loci show strongest signal introgress west africa caribbeansoutheastern usa includ sever gene relat neurolog develop male courtship behavior line previous work show share mate behavior region final hypothes potenti incompat loci may contribut popul genet structur across rang melanogast loci averag high differenti ancestri work contribut understand evolutionari histori key model system provid insight partit divers across rang | D004331;D005075 | T045;T204 |
36,251,859 | core shell structur porous calcium phosphat bioceram sphere enhanc bone regener adequ new bone regener bone defect alway challeng requir excel effici osteogenesi calcium phosphat cap bioceram includ hydroxyapatit ha biphas calcium phosphat bcps extens use clinic bone defect fill due good osteoinduct biodegrad first time design fabric two porous cap bioceram granul core shell structur name accord composit bcp ha ha bcp core shell spheric shape porous structur granul achiev calcium algin gel mold technolog combin h foam process granul could stack build porous structur poros micropor size distribut report good new bone ingrowth vitro experi confirm ha bcp bioceram granul could promot prolifer osteogen abil cocultur bone marrow mesenchym stem cell inhibit differenti raw cell osteoclast vivo week implant critic size femor bone defect anim model show higher bone volum fraction bone miner densiti ha bcp group bcp ha pure ha bcp group histolog analysi discov new bone tissu ha bcp group invad surfac insid granul bioceram phase replac new bone higher degre vascular defect region repair ha bcp reveal microvascular perfus angiographi term higher vessel volum fraction current studi demonstr core shell structur ha bcp bioceram granul could promis candid bone defect repair | D006861;D002130 | T121;T197;T130 |
36,251,855 | associ singl nucleotid polymorph mirna gastric cancer scope review background gastric cancer gc third lead caus cancer relat mortal worldwid singl nucleotid polymorph snps microrna mirna believ affect occurr progress cancer alter express biolog function mirna method present scope review design evalu discuss microrna snps mir snps found associ gc follow two context biolog effect gc base snp local associ mirna snps clinic factor suscept tumor size metastasi overal surviv prognosi gc result conclus inform mirna collect includ snps proven target gene possibl impact snps gc outcom find suggest etiolog modifi role multipl mirna snps mir mir mir mir mir mir mir gc progress find studi reinforc multipl role mirna snps gc | D013274;D035683 | T123;T191;T114 |
36,251,847 | detect discrimin singl nucleotid polymorph quantif crispr cas catalyt effici specif crispr cas assay attract detect singl nucleotid polymorph snps implic eg cancer sar cov variant assay often employ endpoint measur snp wild type wt activ cas tran cleavag activ howev fundament kinet effect snp versus wt activ remain unknown show endpoint base assay limit arbitrari experiment choic like use report concentr assay durat work best known target concentr import show snp versus wt activ result measur kinet shift cas tran cleavag substrat affin k appar catalyt effici k cat k address endpoint base assay limit develop assay base quantif micha menten paramet appli assay base pair wt target sar cov e gene find k cat k measur wt fold greater lowest k cat k among measur snps compar fold endpoint fluoresc snp k also offer strong abil distinguish snps vari fold case import insensit target concentr last point trend among kinet rate snp base locat within crispr cas target region | D000086402;D000086382 | T005;T067;T047 |
36,251,833 | prodrug hydroxi oxopiperidin yl phosphon enolas inhibitor treatment eno delet cancer cancer harbor homozyg delet glycolyt enzym enolas eno select vulner inhibit paralog isoform enolas eno previous work describ sustain tumor regress activ substrat competit phosphon inhibitor eno hydroxi oxopiperidin yl phosphon hex bis pivaloyoxymethyl prodrug pomhex eno delet intracrani orthotop xenograft model glioblastoma natur metabol due poor pharmacokinet bis ester prodrug studi undertaken identifi potenti non esteras prodrug develop wherea phosphonoamid ester effici bioactiv eno delet glioma cell mcguigan prodrug strategi includ cyclos lipid prodrug exhibit low micromolar ic valu eno delet glioma cell improv stabil human serum activ select prodrug also probe use nci cell line screen support use examin relationship prodrug cell line depend bioactiv | D011355;D063065;D005909;D005910 | T120;T131;T191;T109 |
36,251,801 | transient state kinet plasmodium falciparum apicoplast dna polymeras suggest involv accessori factor effici accur dna synthesi plasmodium causat agent malaria belong phylum apicomplexa apicomplexan includ plasmodium contain essenti nonphotosynthet plastid call apicoplast harbor genom replic dedic organellar replisom replisom employ singl dna polymeras appol expect perform replic transles synthesi unlik replic polymeras process factor appol identifi preliminari structur biochem studi provid overal character appol kinet mechan appol activ remain unknown use transient state method determin kinet replic transles synthesi appol show appol low process effici copi undamag dna moreov appol bypass oxid damag lesion bypass error prone taken togeth result rais follow questionhow polymeras low process effici fidel transles synthesi faith replic apicoplast organellar dna within hostil environ human host hypothes interact putat compon apicoplast replisom andor yet undiscov process factor transform appol effici accur enzym | D063546 | T026 |
36,251,789 | molecular mechan hydrotrop properti gtp atp hydrotrop small amphiphil compound increas aqueous solubl hydrophob molecul recent evid suggest adenosin triphosph atp primari energi carrier cell also assum hydrotrop properti prevent aggreg hydrophob protein mechan hydrotropi unknown compar hydrotrop behavior four biolog nucleosid triphosph ntps use molecular dynam md simul launch atom md simul aqueous solut ntps atp guanosin triphosph gtp cytidin triphosph ctp uridin triphosph utp pyren act model hydrophob compound spectroscop report aggreg gtp prevent pyren aggreg effect dissolut achiev presenc ctp utp higher stabil base stack guanin respons higher hydrotrop effici gtp consist simul spectroscop measur also suggest hydrotrop activ gtp higher atp stack aromat pyren aromat base ntps characterist featur hydrotrop properti atp gtp also dissolv cluster di tripeptid contain tryptophan equal potenc import presenc aromat amino acid necessari condit hydrotrop potenc atp gtp result broad implic hydrotrop design pharmaceut industri well possibl cell employ gtp hydrotrop regul hydrophob protein aggreg membran less biolog condens | D000255;D066329 | T123;T121;T116;T114 |
36,251,783 | chemistri secondari organ aerosol format reaction monoterpen oh radic presenc x oxid volatil organ compound voc emit atmospher natur anthropogen sourc lead format ozon secondari organ aerosol soa particl impact air qualiti climat studi report investig product reaction five biogen monoterpen oh radic import daytim oxid condit mimic chemistri occur pollut air develop mechan explain format experi conduct environment chamber inform ident gas phase molecular product obtain use onlin mass spectrometri liquid chromatographi two method function group analysi use character soa composit gas phase product reaction similar form previous studi reaction monoterpen radic import nighttim oxid contain various combin nitrat carbonyl hydroxyl ester ether group spite less soa form ohno x reaction compos monom soa form radic reaction consist acet hemiacet oligom form particl phase accret reaction addit appear monom underw particl phase hydrolysi wherea oligom differ due primarili arrang hydroxyl carbonyl nitrat ether group monom turn explain differ oh radic reaction mechan result provid insight impact voc structur amount composit soa form atmospher oxid influenc import aerosol properti volatil hygroscop | D055549;D010126;D000393 | T131;T103;T109 |
36,251,776 | brac dataset breast carcinoma subtyp h e histolog imag breast cancer common diagnos cancer regist highest number death women advanc diagnost activ combin larg scale screen polici signific lower mortal rate breast cancer patient howev manual inspect tissu slide pathologist cumbersom time consum subject signific inter intra observ variabl recent advent whole slide scan system empow rapid digit patholog slide enabl develop artifici intellig ai assist digit workflow howev ai techniqu especi deep learn requir larg amount high qualiti annot data learn construct task specif dataset pose sever challeng data acquisit level constraint time consum expens annot anonym patient inform paper introduc breast carcinoma subtyp brac dataset larg cohort annot hematoxylin eosin h e stain imag advanc ai develop automat character breast lesion brac contain whole slide imag wsis region interest roi extract wsis wsi respect roi annot consensus three board certifi pathologist differ lesion categori specif brac includ three lesion type ie benign malign atyp subtyp seven categori best knowledg largest annot dataset breast cancer subtyp wsi roi level furthermor includ understudi atyp lesion brac offer uniqu opportun leverag ai better understand characterist encourag ai practition develop evalu novel algorithm brac dataset breast cancer diagnosi patient care databas url https wwwbracsicarcnrit | D001185;D001943 | T090;T191;T073;T066 |
36,251,770 | ru ii catalyz asymmetr transfer hydrogen chalcon water applic enantioselect synthesi flavan bwc tephrowatsin e oxo tether ru ii precatalyst promot one pot ccco reduct chalcon use sodium format hydrogen sourc water asymmetr transfer hydrogen twenti seven diarylpropan ol obtain good excel yield enantiomer puriti data suggest enon first reduc correspond dihydrochalcon select diarylpropan ol co reduct stereoelectron effect electron donat electron withdraw group ortho meta para posit aromat ring evalu oh group b ring well toler allow straightforward enantioselect synthesi two flavan mitsunobu cyclize antivir bwc natur flavan tephrowatsin e | D047188;D002599 | T121;T109 |
36,251,767 | model process catalysi site cluster block applic cellulos hydrolysi interact particl move linear track possibl block obstacl lead crowd imped particl transport kinet particl enzym process catalyz reaction along linear polymer substrat crowd block effect may substanti reduc overal catalyt rate cellulos hydrolysi exocellulas process move along cellulos chain assembl insolubl cellulos particl exampl catalyt transport process detail kinet cellulos hydrolysi caus often observ reduct hydrolysi rate time yet fulli understood crowd block enzym particl thought one import factor affect cellulos hydrolysi exact role mechan clear introduc simpl model base elementari transport process incorpor crowd block effect straightforward way achiev make distinct bind non bind site chain model reproduc rang experiment result main relat earli phase cellulos hydrolysi result indic combin effect cluster bind site togeth occup pattern site enzym molecul play decis role overal kinet cellulos hydrolysi suggest period desorpt rebind enzym molecul could basi strategi partial counter cluster block bind site enhanc rate cellulos hydrolysi general natur model mean could applic also transport process make distinct bind non bind site crowd block expect relev | D044602;D002480;D014242 | T121;T116;T004;T126;T169 |
36,251,763 | scotv singl cell multiom align disproportion cell type represent multiom singl cell data allow us perform integr analysi understand genom regul biolog process howev singl cell sequenc assay perform separ sampl cell popul appli singl cell challeng exist unsupervis singl cell align algorithm primarili benchmark coassay experi investig reveal method perform well noncoassay singl cell experi disproportion cell type represent across measur domain therefor extend previous work singl cell align use optim transport scot use unbalanc gromov wasserstein optim transport handl disproportion cell type represent differ sampl size across singl cell measur method scotv give state art align perform across five non coassay data set simul real world also integr multipl singl cell measur preserv self tune capabl comput tractabl origin version | D000465;D023281 | T170;T091 |
36,251,758 | multimod singl cell translat align semi supervis learn singl cell multi omic technolog enabl comprehens interrog cellular regul yet singl cell assay measur one type activ transcript chromatin access dna methyl chromatin architectur cell enabl multimod view individu cell propos polarbear semi supervis machin learn framework facilit miss modal profil predict singl cell cross modal align polarbear learn translat modal use data co assay measur coupl larg quantiti singl assay data avail public databas semi supervis scheme mitig issu relat low cell quantiti high sparsiti co assay data polarbear first pre train beta variat autoencod modal use co assay singl assay profil learn robust represent individu cell use co assay label train translat cell represent semi supervis framework enabl us predict miss modal profil match singl cell across modal improv accuraci compar fulli supervis method thus facilit multimod data integr | D000069553;D002843 | T116;T066 |
36,251,754 | valid name cyanobacterium cyanobacterium stanieri propos cyanobacteriota phyl nov decis intern committe systemat prokaryot icsp place rank phylum rule intern code nomenclatur prokaryot icnp phylum name end ota base name type genus enabl valid public phylum name cyanobacteriota cyanobacterium type genus name cyanobacterium type speci cyanobacterium stanieri effect publish rippka cohen bazir name valid publish rule icnp name intern code nomenclatur bacteria rule icn intern code nomenclatur alga fungi plant name intern code botan nomenclatur propos name cyanobacterium gen nov cyanobacterium stanieri sp nov valid public provis icn upon valid name also valid publish icnp accord general consider rule also propos phylum name cyanobacteriota phyl nov rule icnp | D000458;D005227 | T123;T007;T168;T109 |
36,251,753 | zavarzinia marina sp nov novel hydrocarbon degrad bacterium isol deep chlorophyl maximum layer seawat west pacif ocean emend descript genus zavarzinia gram stain negat motil non spore form strict aerob rod shape bacteri strain adcm isol seawat sampl collect deep chlorophyl maximum layer west pacif ocean strain adcm grew c optimum c ph ph presenc nacl wv phylogenet analysi base rrna gene sequenc indic belong genus zavarzinia sequenc similar zavarzinia compransori dsm zavarzinia aquatili jcm respect digit dna dna hybrid averag nucleotid ident valu strain adcm two type strain respect princip fatti acid c cyclo c sum featur c c andor c c c predomin respiratori quinon q polar lipid diphosphatidylglycerol two phosphatidylethanolamin two phosphatidyglycerol unidentifi lipid genom dna gc content strain adcm base phylogenet analysi genom base related indic well phenotyp genotyp characterist strain adcm repres novel speci within genus zavarzinia name zavarzinia marina sp nov propos type strain adcm mccc kctc | D002308;D002734 | T123;T109 |
36,251,750 | acuticoccus kalidii sp nov aminocyclopropan carboxyl acc deaminas produc endophyt root kalidium cuspidatum aminocyclopropan carboxyl acc deaminas produc gram stain negat strict aerob non motil yellow reddish oval shape bacteri strain design mdp isol root kalidium cuspidatum tumd right banner inner mongolia pr china mdp grew c optimum c ph optimum ph nacl optimum strain posit catalas oxidas phylogenet tree base rrna gene sequenc indic mdp cluster acuticoccus yangtzensi jl share less rrna gene similar yangtzensi jl acuticoccus mangrovi b acuticoccus sedimini ptg acuticoccus kandelia j type strain respect howev phylogenom tree show cluster kandelia j mdp contain q major respiratori quinon well two minor respiratori quinon q q major polar lipid diphosphatidylglycerol phosphatidylethanolamin phosphatidylglycerol unidentifi phospholipid unidentifi glycolipid four unidentifi lipid genom dna gc content digit dna dna hybrid score averag nucleotid ident base blast valu mdp yangtzensi jl kandelia j mangrovi b sedimini ptg respect phylogenet phenotyp characterist allow discrimin mdp phylogenet relat novel speci acuticoccus kalidii sp nov therefor propos type strain mdp cgmcc kctc | D019663;D060026 | T004;T002 |
36,251,742 | deinococcus betula sp nov deinococcus arbori sp nov novel bacteria isol bark birch tree betula platyphylla two reddish colour bacteri strain hmf hmf isol bark birch tree betula platyphylla togeth two strain design hmf hmf cell observ gram stain negat oval short rod shape non motil phylogenet analysi base rrna gene sequenc indic four isol belong genus deinococcus famili deinococcacea highest similar deinococcus multiflagellatus id form clade phylogenet tree menaquinon respiratori quinon predomin fatti acid sum featur c c andor c c c c c c strain hmf contain two unidentifi phosphoglycolipid nine unidentifi glycolipid one unidentifi aminolipid three unidentifi phospholipid three unidentifi polar lipid strain hmf contain one unidentifi phosphoglycolipid four unidentifi glycolipid one unidentifi aminophospholipid one unidentifi phospholipid one unidentifi polar lipid dna gc content strain hmf hmf mol respect averag nucleotid ident digit dna dna hybrid valu two isol close relat multiflagellatus respect base result phenotyp phylogenet character four isol consid repres two novel speci genus deinococcus name deinococcus betula sp nov deinococcus arbori sp nov propos type strain hmf kctc nbrc hmf kctc nbrc | D034301 | T007 |
36,251,741 | metallosphaera javensi sp nov novel speci thermoacidophil archaea isol volcan area novel thermoacidophil archeaon strain j dsm jcm isol hot pool volcan area java indonesia cell strain irregular motil cocci diamet aerob organoheterotroph growth casamino acid observ optimum temperatur c rang c optimum ph rang various organ compound util includ greater varieti sugar report growth speci genus chemolithoautotroph growth observ reduc sulphur compound includ miner sulphid ferric iron reduc anaerob growth element sulphur cellular lipid calditoglycerocaldarchaeol caldarchaeol deriv organ contain respiratori quinon caldariellaquinon basi phylogenet chemotaxonom comparison closest relat conclud strain j repres novel speci name metallosphaera javensi propos low dna dna related valu rrna gene averag nucleotid ident ani distinguish j speci genus metallosphaera dna gc content highest among known speci genus | D001105;D016943 | T194 |
36,251,736 | antiskin age effect indol alkaloid n glycosid ginkgo fruit ginkgo biloba fruit tnf expos human dermal fibroblast human skin age intern extern factor character tnf overproduct therefor aim identifi natur product suppress damag occur cutan dermal fibroblast expos tnf protect effect indol alkaloid n glycosid ginkgosid b dimethyl ester gbde isol ginkgo fruit ginkgo biloba fruit evalu tnf stimul human dermal fibroblast hdfs gbde inhibit tnf induc mmp express fold p revers decreas collagen level fold p effect gbde due suppress phospolylaton mapk erk jnk p fold p akt fold p compar tnf group gbde also reduc express cox fold p increas express ho fold p addit gbde inhibit express pro inflammatori cytokin il il il fold p result provid experiment evid gbde protect skin damag includ age | D020441;D014409 | T129;T116;T002 |
36,251,734 | long term use shark breed ground three decad mate site fidel nurs shark ginglymostoma cirratum understand shark mate dynam mate site use may vital speci manag dri tortuga courtship mate ground dtcmg known mate site nurs shark ginglymostoma cirratum sinc yr studi document long term site fidel area data adult shark femal male tag pit fin acoust tag shark tag least return dtcmg subsequ year june juli mate season known individu return differ mate season period year indic life span extend well forti speci return shark n monitor year n monitor year male arriv annual may june depart juli wherea femal arriv biennial triennial june secondari peak site use septemb august like associ thermoregul gestat mate season male made frequent visit shorter durat median visit h per visit dtcmg wherea femal made fewer visit remain site longer period median visit h per visit femal typic mate biennial show triennial cycl case mani femal switch cycl least pattern would reduc potenti reproduct lifetim output femal compar would project strict biennial cycl long term mate site fidel shark popul reveal import identifi protect mate site elasmobranch speci | D012754 | T013 |
36,251,732 | role socioeconom factor develop mycetoma result household survey sennar state sudan mycetoma chronic progress destruct diseas subcutan tissu bone caus certain speci bacteria fungi conduct cross section communiti base studi alongsid map mycetoma five administr unit high mycetoma endem eastern sennar local sennar state sudan | D008271 | T047 |
36,251,731 | hippocamp medial prefront cortic encod structur task represent follow progress interleav train schedul memori generalis may underpin either encod retriev base generalis mechan differ train schedul may bias learner favour one mechan use transit infer task investig whether generalis influenc progress vs random interleav train overnight consolid consecut day particip learnt pairwis discrimin two transit hierarchi test fmri infer perform consist better follow progress train pair apart transit hierarchi bold pattern similar correl hierarch distanc left hippocampus hip medial prefront cortex mpfc follow train schedul result consist use structur represent direct encod hierarch relationship task featur howev effect observ mpfc recent learnt relationship furthermor mpfc appear maintain structur represent particip perform chanc infer task conclud human preferenti employ encod base mechan store map like relat code use memori generalis code express hip mpfc follow progress interleav train suffici accur infer | D006624;D008279 | T026;T060;T059;T170;T023 |
36,251,729 | candidatus campylobact infan detect associ diarrhea children age peru work hypothesi less common speci campylobact c jejuni c coli play role enter diseas among children low resourc set explain gap detect campylobact use cultur cultur independ method candidatus campylobact infan c infan recent detect stool sampl children hypothes play role campylobact epidemiolog low middl incom countri lmic studi determin preval c infan symptomat asymptomat stool sampl children live iquito peru stool sampl children diarrhea stool sampl children without diarrhea age two evalu use multiplex qpcr assay detect campylobact spp rrna campylobact jejuni campylobact coli cadf gene c infan lpxa shigella spp ipah c infan detect symptomat sampl asymptomat sampl associ diarrhea presenc target evalu use univari logist regress c infan associ diarrhea fifti one percent campylobact posit fecal sampl negat c jejuni c coli c infan via qpcr shotgun metagenom confirm presenc c infan among posit c infan posit stool sampl c infan explain diagnost gap stool children diarrhea gap children without diarrhea posit poor cadf primer perform better explain observ gap preval atyp non c jejunicoli speci | D002169;D002167 | T047;T007 |
36,251,728 | potenti earli flower homolog chlamydomona involv redviolet blue light signal pathway degrad rhythm chloroplast light play major role reset circadian clock allow organ synchron environment day night cycl chlamydomona light induc degrad circadian clock protein rhythm chloroplast roc consid one key event reset circadian clock redviolet blue light signal shown reach clock via differ molecular pathway howev mani particip compon pathway yet elucid use forward genet approach use report strain express roc luciferas fusion protein isol mutant show impair roc degrad respons wide rang visibl wavelength impair light induc phosphoryl roc result suggest effect differ wavelength converg act roc roc phosphoryl furthermor mutant show weaken phase reset respons light circadian rhythmic remain larg unaffect constant light constant dark condit surpris gene disrupt mutant found encod protein possess weak similar arabidopsi thaliana earli flower elf result suggest protein involv mani differ light signal pathway chlamydomona circadian clock howev may influenc transcript oscil chlamydomona great extent studi provid opportun understand mechan under light induc clock reset explor evolut circadian clock architectur viridiplanta | D002696;D057906;D017360;D029681 | T040;T116;T002 |
36,251,726 | evolutionari game analysi pollut nimbi facil reconstruct base public particip behavior advanc urban expans urban area nimbi back yard environment public facil increas day day meaning incorpor public particip regulatori process exist pollut nimbi facil enterpris establish tripartit game model local govern pollut nimbi facil enterpris public evolut stabil analysi simul analysi strategi carri pareto optim solut obtain result show strategi choic player three parti game differ differ stabil condit system broken bad state increas govern punish local govern strict control potenti profit potenti loss pollut enterpris rebuild long term public benefit reduc cost public particip etc three parti common govern mode form strategi evolut speed player three parti game affect strategi choic proport strategi choic proport two player matter strategi choic proport player three parti game chang chang final game result basi comprehens analysi seri relev suggest put forward three aspect govern enterpris public provid certain refer design public particip system pollut nimbi facil | D003256;D004787 | T078;T052;T069;T054 |
36,251,724 | evalu neurotox balbc mice follow chronic exposur polystyren microplast toxic microplast mps attract wide attent research previous studi indic mps produc toxic effect varieti organ aquat organ mammal howev exact neurotox mps mammal still unclear | D060766;D020258;D014874 | T131;T037;T167 |
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