PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,243,881 | insight bacteri composit parmigiano reggiano natur whey starter cultur depend rrna metabarcod portrait natur whey starter nws undefin bacteri communiti produc daili whey previous chees make round applic high temperatur result dairi plant nws continu evolv undefin mixtur sever strain andor speci lactic acid bacteria whose composit perform strong depend select pressur act incub nws critic assur consist chees make process littl known composit function featur plant plant fluctuat integr rrna metabarcod cultur depend method profil bacteri communiti nws sampl product area parmigiano reggiano chees rrna metabarcod analysi reveal two main nws communiti type name nws type h nws type lactobacillus helveticus abund nws type h whilst lactobacillus delbrueckiist thermophilus nws type respect base predict metagenom function nws type h sampl enrich function pathway relat galactos catabol purin metabol nws type pathway relat aromat branch chain amino acid biosynthesi flavor compound precursor cultur depend approach reveal low cultiv individu coloni axen cultur high genet divers pool cultiv survivor co cultur experi show ferment perform decreas reduc bacteri complex inoculum suggest biotic interact cross feed relationship could take place nws communiti assur phenotyp robust even though data direct predict ecolog interact studi provid basi experi target understand select regim affect composit bacteri interact ferment perform nws | D005516;D007778 | T007;T067 |
36,243,879 | effect catechin enrich diet associ moder physic exercis prevent hypertens spontan hypertens rat hypertens repres main risk factor onset cardiovascular diseas pharmacolog treatment control hypertens associ new treatment involv physic activ andor intak natur compon nutraceut report effect produc combin natur compon catechin moder exercis program develop hypertens spontan hypertens rat compar individu treatment arteri blood pressur heart rate measur non invas method rat random assign four group rat subject moder physic exercis rat catechin enrich diet rat subject moder physic exercis combin catechin enrich diet control untreat rat left age treatment appli week statist analysi reveal three treatment signific reduc week increas arteri blood pressur observ control rat sbp p dbp p howev reduct arteri blood pressur induc combin treatment higher induc singl treatment prolong treatment show strong antioxid properti data show physic activ diet enrich catechin individu import hypotens effect associ produc higher hypotens effect singl treatment even abl decreas blood pressur longer time find import implic develop protocol appli novel hypertens prevent procedur | D002392;D006973 | T121;T047;T109 |
36,243,878 | identifi pre exist condit multimorbid pattern associ hospit mortal patient covid investig associ wide rang comorbid covid hospit mortal assess influenc multi morbid risk covid relat death use larg region cohort hospit patient retrospect cohort studi conduct use patient administr system admiss discharg data intern classif diseas th edit icd diagnosi code use identifi common comorbid outcom measur individu lymphoma odd ratio ci metastat cancer ci solid tumour without metastasi ci liver diseas ci congest heart failur ci chronic obstruct pulmonari diseas ci obes ci renal diseas ci dementia ci increas risk covid mortal asthma associ lower risk death compar non asthma control ci individu two ci p three comorbid ci p increas higher risk death compar under condit furthermor multi morbid pattern analys identifi cluster condit hospitalis covid patient use k mode cluster unsupervis machin learn techniqu six patient cluster identifi recognis co occurr covid differ combin diseas name cardiovascular renal diseas patient cluster mental neurolog disord metabol endocrin diseas patient cluster respiratori cardiovascular diseas patient cluster cancer genitourinari well metabol endocrin diseas patient cluster metabol endocrin diseas cardiovascular diseas patient cluster mental neurolog disord cardiovascular diseas patient cluster highest mortal report cluster | D001249;D000086382;D002318;D009369 | T191;T047;T067 |
36,243,876 | suboptim blood pressur control associ factor among peopl live diabet mellitus sub saharan africa systemat review meta analysi suboptim blood pressur control among peopl live diabet mellitus dm one primari caus cardiovascular complic death sub saharan africa ssa howev pauciti evid preval associ factor suboptim blood pressur control ssa therefor review aim estim pool preval associ factor among peopl live dm ssa method systemat search pubm african journal onlin hinari sciencedirect googl scholar direct googl access observ studi conduct ssa microsoft excel spreadsheet use extract data export statamp version analys heterogen across studi check use cochran q test statist test small studi effect check use funnel plot symmetri egger statist test signific level random effect model use estim pool preval associ factor suboptim blood pressur control confid interv ci signific level p | D000959;D003920 | T121;T047 |
36,243,875 | structur basi recognit antihistamin drug human histamin receptor histamin receptor belong g protein coupl receptor gpcr superfamili play import role regul histamin neurotransmitt central nervous system potenti target treatment neurolog psychiatr disord report crystal structur human histamin receptor h r bound antagonist pf resolut combin comput function assay structur reveal bind mode antagonist alloster cholesterol molecular dynam simul molecular dock differ antihistamin elucid conserv ligand bind mode find therefor expect facilit structur base design novel antihistamin | D006632;D011968 | T116;T192;T121;T109;T123 |
36,243,874 | self restrict circular rna circsox suppress malign progress sox amplifi lusc lung squamous cell carcinoma lusc histolog subtyp non small cell lung cancer wors progress sri box transcript factor sox copi number amplif cna oncogen driver patient diagnos lusc thus sox repres effect therapeut target sox amplifi lusc howev sox protein consid undrugg report express circular rna cicsox sox amplifi lusc patient sox lusc express circsox manifest increas surviv outcom circsox suppress prolifer metastasi sphere format sox amplifi lusc vitro vivo circsox origin revers strand sox gene sequenc revers complement partial utr sox code transcript msox circsox bound auf occupi utr msox induc degrad msox general circsox endogen self restrict circrna sox amplifi lusc circsox might effect stabl nucleic acid drug candid sox amplifi lusc low immunogen | D002289;D002294;D008175 | T191 |
36,243,871 | mainten neurotransmitt ident hox protein homeostat mechan hox transcript factor play fundament role earli pattern also express continu embryon stage adulthood nervous system howev function signific sustain express remain unclear c elegan motor neuron mns find lin scrdfdhox continu requir post embryon life maintain neurotransmitt ident core element neuron function lin act direct co regul gene defin cholinerg ident eg unc vacht cho cht show lin mab antphox transcript factor unc collierebf oper posit feedforward loop ensur continu robust express cholinerg ident gene final identifi two compon design principl homeostat control hox gene express adult mns hox transcript autoregul counterbalanc negat unc feedback find uncov noncanon role hox protein post embryon life critic broaden function repertoir earli pattern control neurotransmitt ident | D017173;D029742 | T116;T204 |
36,243,869 | mild pulmonari hemodynam alter patient system sclerosi relev new escer definit pulmonari hypertens impact mortal definit pre capillari pulmonari hypertens ph modifi lower mean pulmonari arteri pressur mpap threshold mmhg addit mandatori criterion pulmonari vascular resist pvr wood unit wu object estim proport patient reclassifi pre capillari ph use new escer hemodynam criteria ie mpap mmhg pvr wu describ clinic characterist outcom studi relationship pvr surviv patient mpap mmhg | D006976;D012595 | T047;T046 |
36,243,868 | covid vaccin updat vaccin effect sar cov variant booster advers effect immun correl protect coronavirus diseas covid sever public health challeng centuri two year emerg rapid develop deploy effect covid vaccin success control pandem great reduc risk sever ill death associ covid howev due abil rapid evolv sar cov virus may never erad mani import new topic work need live virus long time end hope provid essenti knowledg research work improv futur covid vaccin review provid date summari current covid vaccin discuss biolog basi clinic impact sar cov variant subvari analyz effect various vaccin booster regimen differ sar cov strain addit review potenti mechan vaccin induc sever advers event summar current studi regard immun correl protect final discuss develop next generat vaccin | D000086382;D014765 | T121;T047;T067;T129 |
36,243,866 | respons circul metabolit oral glucos challeng risk cardiovascular diseas mortal communiti new biomark identifi cardiovascular diseas cvd risk earlier cours need enabl target approach primordi prevent evalu whether intraindividu chang blood metabolit respons oral glucos toler test ogtt may provid increment inform regard risk futur cvd mortal communiti | D002318 | T047 |
36,243,865 | circular rna hsacirc aggrav ovarian cancer progress regul elk via spong mir ovarian cancer common caus death among women health problem worldwid circ confirm oncogen involv cancer progress gastric cancer howev role circ ovarian cancer remain unclear need elucid retrospect studi aim investig under mechan circ ovarian cancer | D035683;D010051 | T191;T123;T114 |
36,243,864 | disrupt methyl pattern birth persist earli childhood prospect cohort analysi alter epigenom risk factor multipl diseas state demonstr past disrupt epigenom earli pregnanc periconcept demonstr alter methyl may associ assist reproduct technolog undesir clinic outcom birth low birth weight previous defin alter methyl calcul base statist upper lower limit outlier cpgs compar popul outlier methyl phenotyp omp aim studi determin whether children thus identifi possess omp birth dna methyl cord blood persist outlier earli childhood base salivari dna methyl | D019175;D044127 | T045;T044 |
36,243,863 | engin saccharomyc cerevisia product dihydroquercetin naringenin dihydroquercetin dhq power bioflavonoid number health promot qualiti show potenti treatment number disord dihydroquercetin biosynthesi promis solut meet rise demand dihydroquercetin howev due signific accumul eriodietyol eri naringenin nar dihydrokaempferol dhk metabolit yield dhq biosynthesi low result hindranc biosynthesi dhq | D009251;D012441 | T004;T126;T116 |
36,243,862 | trimethylamin gut bacteria metabolit air pollut increas blood pressur marker kidney damag includ proteinuria kim rat trimethylamin oxid tmao biomark cardiovascular renal diseas tmao origin oxid trimethylamin tma product gut microbiota manufactur industri deriv pollut flavin monooxygenas fmos effect chronic exposur tma cardiovascular renal system undetermin | D000393;D007674 | T047;T131 |
36,243,861 | genom wide identif key enzym encod gene catalyt role two oxoglutar depend dioxygenas involv flavonoid biosynthesi cannabi sativa l flavonoid necessari plant growth resist advers stress also essenti nutrient human diet health among metabolit produc cannabi sativa c sativa phytocannabinoid undergon extens research structur biosynthesi biolog activ besid phytocannabinoid c sativa also rich terpen alkaloid flavonoid although littl research conduct area | D002188;D049308 | T116;T002;T167;T121;T109;T126 |
36,243,859 | target myd use peptid load mesenchym stem cell membran deriv synthet vesicl treat system inflamm mesenchym stem cell msc secret extracellular vesicl ev regen profil increas number studi focus util msc ev therapeut drug deliveri howev ev usual produc cell low quantiti pack numer cytoplasm compon may unfavor drug load studi develop simpl process generat membran vesicl direct cell refer synthet eukaryot vesicl syev hypothes msc deriv syev effici load anti inflammatori drug load vesicl strong suppress system inflamm induc bacteri outer membran vesicl omv syev generat msc membran serial extrus cell ionic stress subsequ vesicul membran sheet lead high yield puriti syev cytosol compon remain syev given macrophag mice expos omv releas pro inflammatori cytokin similar attenu compar treatment natur ev load syev larg number peptid target myd observ enhanc therapeut potenti load vesicl omv induc macrophag vivo experi show peptid encapsul msc syev suppress cytokin product synergist taken togeth find suggest syev base therapeut high interest platform deliv advanc therapeut drug treatment system inflamm without sever side effect | D000067128;D059630 | T026;T025 |
36,243,836 | combin osmac metabolom genom method product annot halogen azaphilon ilicicolin termit symbiot fungi gather collect termit mutualist strain french guiana explor metabolit symbiot microorgan molecular network reconstruct metabolom analysi use lc esi msms methodolog led us identifi two famili chlorin polyketid ie azaphilon penicillium sclerotiorum ilicicolin neonectria discophora defin biosynthet pathway relat two type scaffold use whole genom sequenc approach follow hybrid assembl short long read found two biosynthet gene cluster includ two fad depend halogenas exploit enzymat promiscu two identifi fad halogenas sought biosynthes novel halogen metabolit osmac strategi use result product bromin analog ilicicolin azaphilon well iodin analog azaphilon | D020049;D061065 | T121;T109;T204 |
36,243,835 | effect action conting social percept independ person like appear relat deactiv frontal compon self agenc network detect object movement conting one action ie movement action conting influenc social percept object interact object tend creat good impress howev remain unclear whether neural represent action conting associ subsequ socio cognit evalu contact agent whether appear agent eg face non face like avatar essenti effect studi conduct function magnet reson imag fmri task two phase contact contact face non face like avatar move conting non conting recognit rate static imag avatar deactiv frontopariet self agenc network activ reward network main effect action conting contact phase consist previous find recognit phase static avatar previous move conting manner deactiv frontal compon frontopariet network bilater insula inferior middl frontal gyri regardless person like appear result impli frontal deactiv may underli effect action conting subsequ social percept independ person like appear | D017397;D021641;D012938 | T023;T041;T030;T029 |
36,243,830 | post endotoxin exposur induc lung inflamm resolut consequ benefici impact lung deliv il therapi although lung diseas typic result long term exposur even robust one time exposur result long last consequ endotoxin ubiquit environmentaloccup inflammatori agent often use model airway inflamm use murin model return lung homeostasi follow high dose inhal lipopolysaccharid lps g exposur delin week lps induc rapid weight loss releas proinflammatori mediat inflammatori cell influx prolong persist activ macrophag cdc cdb recruitedtransit cdc int cdb monocyt macrophag week next lung deliv recombin r interleukin il intratrach administ dose initi h follow lps g exposur day il therapi reduc lps induc weight loss increas blood glucos level wherea differ lps induc bronchoalveolar lavag airway fluid cellular influx total lung cell infiltr reduc ril treatment post lps exposur treatment ril strike reduc lavag fluid lung homogen level tumor necrosi factor reduct respect il reduct cxcl reduct cxcl reduct lps induc recruit monocyt macrophag cdc int cdb reduc ril correspond lps induc lung tissu ccr inflammatori monocyt macrophag reduc ril also reduct lps induc lung neutrophil lymphocyt subpopul collagen content vimentin express find support import studi resolut process develop treatment unintend environmentaloccup biohazard exposur short term lung deliv ril favor hasten inflammatori recoveri process follow acut high dose inhal lps exposur | D016753;D011014 | T050;T047;T116;T129 |
36,243,826 | later confin growth cell activ lef depend pathway regul cell state transit long term sustain mechano chemic signal tissu microenviron regul cell state transit recent work show later confin growth fibroblast induc dedifferenti program howev molecular mechan under mechan induc cell state transit poor understood paper identifi lef critic somat transcript factor mechan regul de differenti pathway network optim method appli time laps rna seq data identifi lef depend signal potenti regul cell state transit show lef knockdown result regul fibroblast de differenti lef direct interact promot region downstream reprogram factor also evalu potenti upstream activ pathway lef includ smad atf nfkb beta catenin pathway therebi identifi smad atf may critic lef activ collect describ import mechanotransduct pathway includ lef upon activ progress later cell confin result fibroblast de differenti | D040542;D051176 | T044;T123;T116 |
36,243,824 | dynam traffic flow model cognit driver sensit lagrangian scope new microscop traffic flow model establish base heterogen driver sensit new model driver sensit defin depend headway distanc preced vehicl similar bando optim veloc function introduc formul cognit driver sensit util modifi form bando optim veloc function simpl methodolog use improv bando optim veloc function implement develop cognit driver sensit function establish correl flow field densiti human driver respons model high advanc introduc human driven traffic flow field consid driver mental behavior activ use linear stabil condit elucid neutral stabil condit seri numer simul indic present model describ dynam differ convent model assum constant driver sensit | D001334 | T056 |
36,243,816 | vitro assembl posit contract divis ring minim cell construct minim machineri autonom self divis synthet cell major goal bottom synthet biolog one paradigm e coli divisom mincd protein system guid assembl posit presum contractil ring base ftsz membran adaptor ftsa demonstr full vitro reconstitut machineri consist five protein within lipid vesicl allow observ follow sequenc event real time assembl isotrop filament ftsz network condens ring like structur along pole pole mode select min oscil result equatori posit onset ring constrict deform vesicl spheric shape besid demonstr essenti featur highlight import decis experiment factor macromolecular crowd result provid except showcas emerg cell divis minim system may repres step toward develop synthet cell | D004926;D029968 | T007;T116 |
36,243,815 | essenti role tmprss sar cov infect murin airway cultur cell sar cov infect cell via multipl pathway use differ host proteas recent studi shown furin tmprss furintmprss depend pathway play minor role infect omicron variant confirm omicron use furintmprss depend pathway ineffici enter cell main use cathepsin depend endocytosi pathway tmprss express veroetmprss calu cell case despit effici cleavag spike protein omicron howev airway tmprss knockout mice omicron infect signific reduc furthermor show propag mous adapt sar cov qhmusx strain human clinic isol beta gamma reduc tmprss knockout mice therefor omicron variant nt except use tmprss vivo analysi tmprss knockout mice import evalu sar cov variant conclus studi show tmprss critic import sar cov infect murin airway includ omicron variant | D000086382;D000086402 | T047;T067;T005 |
36,243,811 | speci identif maldi tof ms gap pcr rflp non aureus staphylococcus mammaliicoccus streptococcus spp associ sheep goat mastiti staphylococci streptococci common caus intramammari infect small rumin reliabl speci identif crucial understand epidemiolog impact anim health welfar appli maldi tof ms gap pcr rflp non aureus staphylococci nas mammaliicocci nasm streptococci isol milk sheep goat mastiti top identifi nas staphylococcus epidermidi follow staph chromogen haemolyticus capra simulan accord method agreement rate ar maldi tof ms staph microti xylosus equorum petrasii warneri staph sciuri mammaliicoccus sciuri arletta capiti cohnii lentus lentus pseudintermedius succinus isol identifi pcr rflp show ar staph equorum warneri arletta capiti pseudintermedius staph xylosus remain nasm top identifi streptococcus streptococcus uberi follow strep dysgalactia parauberi strep gallolyticus accord method ar one isol identifi differ speci maldi tof ms pcr rflp conclus maldi tof ms pcr rflp show high level agreement identif preval nas streptococci caus small rumin mastiti therefor gap pcr rflp repres good identif altern maldi tof ms avail nevertheless issu remain staph haemolyticus minor nas speci includ staph microti speci novel genus mammaliicoccus | D002418;D015511;D008414;D012757;D013203 | T047 |
36,243,808 | c reactiv protein valu surgeri inflammatori bowel diseas still good marker intra abdomin complic retrospect cohort studi procedur crp inflammatori bowel diseas surgeri c reactiv protein crp use predict test earli detect abdomin complic colorect surgeri inflammatori bowel diseas ibd respons chronic inflamm abnorm basal crp could influenc interest manag abdomin surgeri aim studi evalu crp indic postop complic specif ibd popul | D002097;D015212 | T047;T116;T129 |
36,243,807 | optim tool time respons reassess neoadjuv chemoradi rectal cancer reassess tool respons long cours neoadjuv chemoradi treatment ncrt patient local advanc rectal cancer larc import predict complet respons cr thus decid whether wait watch strategi implement patient choos routin reassess tool optim use still unclear research studi | D020360;D012004 | T191;T061 |
36,243,806 | radiom featur assess tumor infiltr lymphocyt correl molecular trait tripl negat breast cancer tumor infiltr lymphocyt til becom promis biomark assess tumor immun microenviron predict immunotherapi respons howev assess til reli invas patholog slide | D016246;D064726 | T191;T025 |
36,243,804 | effect backpack load intersegment motion foot plantar pressur individu mild flatfoot feet play essenti role shock absorpt foot postur close relat gait compensatori mechan heavi load condit individu mild flatfoot poor understood author countri individu mild flatfoot draft activ duti soldier particip militari ruck wear heavi backpack studi investig effect backpack load gait foot plantar pressur possibl differ particip mild flatfoot averag weight backpack militari ruck approxim kg simul studi | D005413 | T190;T019 |
36,243,801 | enpp delet caus mous osteoporosi via mkkp mapkpcna signal pathway apart current understand enzym function mechan ectonucleotid pyrophosphatasephosphodiesteras enpp defici associ osteoporosi unknown aim explor chang express signal pathway bone tissu involv enpp defici | D010024;D048051 | T047;T126;T116 |
36,243,800 | exosom mir p inhibit osteogenesi target igfr regul mtor pathway ossif posterior longitudin ligament ossif posterior longitudin ligament opll disabl diseas whose pathogenesi still unclear effect cure prevent method exosom mirna play import role osteogenesi ectop bone therefor focus downregul mir p opll cell deriv exosom explor mechan exosom mir p inhibit osteogenesi opll | D035683;D017887 | T046;T123;T114 |
36,243,798 | novel microrna signatur detect melanoma liquid biopsi melanoma deadliest form skin cancer metastat diseas associ signific surviv rate drop urgent need consist tumor biomark scale precis medicin reduc cancer mortal aim identifi melanoma specif circul microrna signatur assess valu diagnost tool | D000074166;D008545;D035683 | T191;T123;T114 |
36,243,796 | foundat static dynam absolut concentr robust absolut concentr robust acr introduc shinar feinberg scienc robust equilibrium speci concentr mass action dynam system aim devis mathemat condit ensur robust function biolog system model robust function rest refer empir robust concentr speci remain unvari measur long run across arbitrari initi condit even simpl exampl show acr notion introduc shinar feinberg scienc refer static acr neither necessari suffici empir robust make stronger connect empir robust defin dynam acr properti relat long term global dynam rather equilibrium behavior discuss general dynam system dynam acr properti well parametr famili dynam system relat reaction network find necessari suffici condit dynam acr complex balanc reaction network class network central theori reaction network | D001669;D008954 | T075;T044;T070 |
36,243,795 | intra specif variat sensit bombus terrestri osmia bicorni three pesticid grow evid pesticid may among caus worldwid bee declin result repeat call increas scrutini regulatori assess one recur concern current framework may bias toward assess risk honey bee paradigm requir extrapol toxic inform across bee speci research effort therefor focus quantifi differ sensit across speci howev understand respons pesticid may vari within speci still poor take first step toward fill knowledg gap compar acut lethal hazard sex cast eusoci bee bombus terrestri sex solitari bee osmia bicorni oral contact exposur pesticid sulfoxaflor amistar azoxystrobin glyphos show sensit toward pesticid vari signific within across speci bee weight meaning predictor pesticid suscept howev weight could fulli explain observ differ suggest exist unexplor mechan regul pesticid sensit across bee sex cast data show intra specif respons overlook yet import aspect risk assess pesticid bee | D010575 | T131 |
36,243,791 | role aspergillus nidulan high mobil group b protein hmba orthologu saccharomyc cerevisia nhpp mammalian hmgb high mobil group b protein architectur function element chromatin nhpp extens studi fungal homologu hmgb saccharomyc cerevisia pleiotrop physiolog function despit exist nhpp orthologu filament ascomycet littl known physiolog role besid contribut sexual develop studi function hmba aspergillus nidulan orthologu nhpp show hmba influenc util various carbon nitrogen sourc stress toler secondari metabol hypha elong mainten polar growth addit conduct heterolog express studi demonstr hmba nhpp partial interchang hmba restor snr transcript fit nhpab mutant revers heat sensit nhpap complement sever phenotyp hmba includ ascospor format util various carbon nitrogen sourc radial growth rate hypha elong polar growth howev nhpap complement sterigmatocystin product hmba strain final also show hmba necessari normal express endochitinas chia cell wall model pivot normal mode mainten polar growth | D001233;D002688;D024243;D029701 | T116;T126;T004;T123 |
36,243,789 | parent religios associ chang youth function network organ cognit perform earli adolesc parent religi belief practic religios may profound effect youth especi neurodevelopment complex period adolesc n children median age month femal religi affili adolesc brain cognit develop studi relationship parent religios non religi belief famili valu data youth belief avail topolog properti youth rest state brain network execut function inhibitori control cognit flexibl investig lower caregiv educ famili incom associ stronger parent belief p strength belief type correl lower effici communiti structur robust frontopariet control temporopariet dorsal attent network p lower matrix reason score stronger religi belief negat associ direct indirect multiscal properti salienc default mode network lower flanker dimension card sort score posit associ properti precuneus overal effect small cohen overlap neuromodulatori cognit effect parent belief suggest earli adolesc may perceiv religi belief part context independ rule expect behavior howev religi belief may also differenti affect cognit flexibl attent inhibitori control neural substrat | D000294;D012067 | T055;T078 |
36,243,786 | oropharyng obstruct respiratori system complianc link ventilatori control paramet pediatr obstruct sleep apnea syndrom instabl ventilatori control endotyp trait obstruct sleep apnea syndrom osa studi aim evalu relationship anatom compromis upper oro naso pharynx lower airway ventilatori control measur chemic loop gain otherwis healthi children suffer moder sever osa apnea hypopnea index hour children underw ear nose throat examin measur imped respiratori system allow character peripher lung mechan use extend resist inert complianc model physiolog constrain analyt model base tidal breath analysi allow comput steadi state plant gain steadi state control gain cg steadi state loop gain lg medium frequenc compon feedback control system deduc fifti children median age year enrol oropharyng obstruct associ decreas cg vs ls mmhg p lg vs p nasal obstruct modifi ventilatori control paramet multivari analysi medium frequenc pg negat relat minut ventil respiratori system complianc upper tonsil hypertrophi lower complianc respiratori system airway link ventilatori control children moder sever osa | D000234;D020181 | T023;T047 |
36,243,785 | influenc prenat exercis relationship matern overweight obes select deliveri outcom women overweight obes owob increas risk cesarean birth preterm birth ptb high birth weight infant although regular exercis decreas risk healthi weight women associ explor owob women random week gestat min moder intens exercis n non exercis control n deliveri mode gestat age ga birth weight bw obtain via electron health record pregnant exercis differ risk cesarean birth ptb bw compar control particip owob exercis higher rate cesarean birth vs trend higher ptb vs normal weight babi relat normal weight exercis control race bodi mass index bmi matern exercis reduc relat risk rr cesarean birth cesarean birth predict pre pregnanc bmi fit level wherea bw predict race gestat weight gain gwg pre pregnanc fit level exercis level cesarean birth predict pre pregnanc bmi fit level matern exercis reduc magnitud relat risk cesarean birth matern exercis pre pregnanc fit level gwg predict neonat bwtrial registr influenc matern exercis infant skelet muscl metabolom nct https registerclinicaltrialsgovprsapptemplateeditrecordvm epmodeedit listmodeedit uiduzx ts sidsfwj cxudi | D005081;D000079262;D011295 | T061;T058;T033 |
36,243,784 | assess challeng e learn malaysia pandem covid use geo spatial approach outbreak pandem covid transform educ system countri worldwid follow lockdown measur malaysia malaysian educ system fulli transform convent learn onlin learn known e learn altern minim social contact physic communic curb transmiss covid regard studi aim identifi challeng face student higher learn institut throughout malaysia implement e learn program studi base larg sampl consist student public privat univers result studi analyz inferenti method spatial analysi princip compon analysi mann whitney u test descript method use frequenc analysi percentag analysi find studi suggest locat signific influenc challeng face student throughout implement e learn higher learn institut exampl student rural area identifi vulner group like face technic connect internet access tend declin focus learn prone physic health problem face social isol low digit literaci compar student urban area base geograph analysi student sabah per melaka risk face e learn challeng anomali case student kuala lumpur howev pose anoth differ result compar citi confront similar challeng student rural area studi provid nuanc locat implic vulner group may put disadvantag e learn program find studi help inform relev author policymak improv implement e learn malaysia especi toward vulner group deliv systemat effici | D000086382;D003194 | T047;T067;T065 |
36,243,783 | marin heatwav differ magnitud contrast effect herbivor behaviour global climat chang lead shift abiot condit short term temperatur stress induc marin heatwav mhws affect organ event howev recoveri capac organ like depend magnitud initi stress event experiment assess effect mhw magnitud behaviour physiolog respons common marin gastropod lunella granulata mhw self right behaviour tend becom faster moder mhws wherea trend toward behaviour slow extrem mhws recoveri period ambient temperatur individu experienc extrem mhws show persist small signific negat effect surviv oxygen consumpt rate unaffect mhw magnitud event extrem mhws may negat behaviour consequ tropic marin gastropod physiolog respons may allow continu surviv | D017753;D049851 | T082;T204;T070 |
36,243,779 | fluid restrict manag treatment covid singl center observ studi relationship fluid manag sever ill durat treatment outcom coronavirus diseas covid fulli understood studi aim evalu whether weight chang hospit associ covid sever length hospit stay rout admiss studi assess effect fluid restrict manag patient sever covid covid patient admit hospit juli octob analyz patient treat standard drug therapi base japanes guidelin respiratori support accord sever diseas earli enter nutrit defec manag anticoagul therapi also administ fluid restrict manag perform use furosemid continu renal replac therapi need unless hemodynam instabl hyperlactatemia present patient background rout admiss ambul transfer weight admiss discharg sever ill oxygen therapi g mechan ventil g extracorpor membran oxygen g hospit mortal length hospit stay analyz subject g n g n g n age median iqr year male respect hospit stay day hospit mortal rate respect bodi mass index admiss kgm weight loss admiss kg p jonckheer terpstra test weight loss sever group g g kg n kg n p mann whitney u test length hospit stay day p jonckheer terpstra test fluid restrict manag patient sever covid signific longer hospit length stay weight loss especi transfer hospit | D000086382 | T047;T067 |
36,243,777 | evid death malaria sever pneumonia co infect malaria endem area systemat review meta analysi malaria pneumonia lead caus childhood mortal children year age nevertheless proport death malaria co infect among patient sever pneumonia particular children year age characterist co infect remain poor explor henc present studi aim collat evid malaria among patient sever pneumonia sever pneumonia among patient malaria proport death among patient co infect potenti relev studi search six databas includ pubm scopus web scienc embas ovid medlin identifi studi malaria sever pneumonia co infect publish juli restrict non english languag restrict public year qualiti includ studi determin use strengthen report observ studi epidemiolog strobe pool estim includ pool proport malaria among patient sever pneumonia proport death among patient co infect estim random effect model studi examin studi met elig criteria includ review meta analysi result show proport malaria case among patient sever pneumonia case ci studi proport sever pneumonia case among patient malaria case ci studi proport death among patient co infect ci studi conclus near one fifth patient sever pneumonia malaria one fifth patient malaria sever pneumonia co infect lead death inform rais clinic import diagnosi manag concurr infect patient sever pneumonia investig malaria vice versa detect co infect might provid inform inform physician manag cure co infect patient live area diseas endem | D060085;D008288;D011014 | T050;T047 |
36,243,776 | decontamin potenti date palm fruit via non thermal plasma techniqu potenti surfac dielectr barrier discharg techniqu sdbd evalu decontamin date palm fruit preliminari investig emphas aspergillus niger fungus predomin date sampl post harvest infest influenc sdbd techniqu viabil niger isol date varieti investig document physic chemic character treat date assess statist correl coeffici calcul elucid log reduct niger radial growth observ min exposur day incub simultan reduct ph water activ moistur content treat date observ compar untreat date statist analysi show posit correl physic chemic variabl viabil niger treat sampl therefor believ sdbd treatment promis techniqu decontamin date fruit attack fungi posit impact sustain food secur consum health | D065749 | T168;T002 |
36,243,775 | interact mass spectrometri atlas histon posttransl modif cell acut leukemia holist natur omic studi make ideal suit generat hypothes health diseas sequenc base genom mass spectrometri ms base proteom link epigenet regul mechan howev epigenom current main focus dna methyl status use sequenc technolog studi histon posttransl modif hptms use ms lag part reus raw data impract yet target hptms use epidrug establish promis research avenu cancer treatment therefor present comprehens ms base preprocess hptm atlas date includ cell acut lymphoblast leukemia cell line present data intuit browsabl singl licens progenesi qip project provid essenti qualiti metric allow user assess qualiti data edit individu peptid tri novel annot algorithm export peptid protein data downstream analys exemplifi peptidoformviz tool data resourc set stage general ms base histon analysi provid first reusabl histon dataset epidrug develop | D006657;D007938 | T191;T123;T116 |
36,243,772 | cancermut softwar packag priorit missens cancer variant case studi ambra melanoma cancer genom cancer mutat databas made avail wealth inform missens mutat found cancer patient sampl contextu mean annot predict effect amino acid chang help identifi one like pathogen impact valid mean experiment approach assess impact protein mutat cellular function tumorigen potenti propos integr bioinformat approach cancermut implement python packag cancermut abl gather known missens cancer mutat databas cbioport cosmic annot pathogen score revel well inform sourc also abl add annot protein context mutat found post translat modif site structuredunstructur region presenc short linear motif appli cancermut intrins disord protein ambra key regul mani cellular process frequent deregul cancer mean classifi mutat ambra melanoma ambra high mutat display tumor suppress role next base revel score posit along sequenc local context appli cellular molecular approach valid predict pathogen subset mutat vitro melanoma model identifi two ambra mutat show enhanc tumorigen potenti worth investig highlight use tool cancermut use protein target start minim inform avail https wwwgithubcomelelabcancermut free softwar | D064267;D008545 | T191;T123;T116 |
36,243,768 | loss casz tumor suppressor link oncogen subvers neuroblastoma core regulatori circuitri neural crest lineag regulatori transcript factor tfs form core regulatori circuitri crc neuroblastoma nb specifi noradrenerg tumor phenotyp oncogen subvers crc tfs well document role loss tumor suppressor play remain unclear zinc finger tf casz chromosom p chrp tumor suppressor singl cell rna sequenc data analys indic casz high express develop chromaffin cell coincid express nb crc tfs nb tumor cell casz tumor suppressor silenc crc compon high express find nb crc compon hand direct repress casz express chip seq transcriptom analys reveal restor casz upregul noradrenerg neuron gene repress express crc compon remodel enhanc activ studi identifi restor casz form negat feedback regulatori circuit establish nb crc induc noradrenerg neuron differenti nb | D004268;D009447 | T191;T123;T116 |
36,243,766 | factor promot prohibit success implement normal healthi school lunch program primari school netherland school provid healthi lunch might help improv nutrit qualiti children lunch howev netherland school lunch program common aim studi identifi factor promot inhibit implement school lunch program primari school viewpoint school profession | D005522;D062409 | T056;T057;T095;T079 |
36,243,764 | covid preval infect control measur homeless shelter hostel high incom countri scope review covid pandem disproportion impact homeless popul servic worker especi within homeless shelterhostel set date evid synthes examin outbreak covid among homeless shelter resid servic worker critic review infect control prevent ipac measur scope review offer much need synthesi covid preval within homeless shelter review pertin ipac measur method conduct scope review aim synthes academ gray literatur publish march juli pertain preval covid among resid staff homeless shelter hostel high incom countri covid ipac strategi appli set two review independ screen literatur sever databas includ medlin psycinfo covid global health portal extract data map categor themat discuss | D000086382;D006703 | T047;T095;T098;T067;T033 |
36,243,760 | identifi exist approach use evalu sustain evid base intervent healthcar integr review limit evid evalu sustain evid base intervent ebi healthcar improv integr review aim identifi approach evalu sustain evid base intervent ebi sustain outcom | D003695;D006268 | T093;T058;T073 |
36,243,758 | antigen molecular mimicri viral mediat protect cancer hiv case peopl live hivaid plwha show reduc incid three cancer type name breast prostat colon cancer present studi assess whether molecular mimicri hiv epitop tumor associ antigen consequ cell cross reactiv could provid explan epidemiolog evid | D003110;D015658 | T191;T047 |
36,243,757 | high effici durabl antimicrobi nanocomposit textil healthcar associ infect caus million hospit cost billion dollar everi year potenti solut address problem develop antimicrobi textil healthcar fabric hospit bed gown lab coat etc metal nanoparticl coat textil proven possess antimicrobi properti adopt healthcar facil due risk leach subsequ loss function toxic environment pollut work present develop test antimicrobi zinc nanocomposit textil fabric use novel crescoat process process zinc nanoparticl grown situ within bulk differ natur synthet fabric form safe durabl nanocomposit zinc nanocomposit textil show unpreced microbi reduct log log within h common gram posit gram negat bacteria fungal pathogen furthermor antimicrobi activ remain intact even laundri cycl demonstr high longev durabl textil independ dermatolog evalu confirm novel textil non irrit hypoallergen | D000890;D053768;D053761 | T121;T073 |
36,243,756 | relationship glycat hemoglobin ac level exacerb status patient chronic obstruct pulmonari diseas studi perform razi hospit rasht iran march august popul chronic obstruct pulmonari diseas copd patient copd exacerb group copd stabl group studi variabl includ age sex occup bodi mass index bmi cigarett consumpt durat copd annual hospit dyspnea glycat hemoglobin hbac fev fevfvc indic | D029424 | T047 |
36,243,755 | salt toler qtls endem rice landrac horkuch seedl reproduct stage salin signific negat impact product rice cope increas soil salin due climat chang need develop salt toler rice varieti maintain high yield rice landrac indigen coastal bangladesh great resourc studi genet basi salt adapt studi implement qtl analysi framework reciproc map popul develop salt toler landrac horkuch high yield rice varieti ir aim detect genet loci contribut salt adapt respons two differ development stage rice sensit salin stress identifi qtls trait found uniqu specif development stage addit detect signific effect cytoplasm genom qtl model trait leaf total potassium fill grain weight underscor import consid cytoplasm nuclear interact breed program final identifi qtls co local multipl trait highlight possibl constraint multipl qtl select breed program due differ contribut donor allel differ trait | D012275;D055049 | T168;T040;T002 |
36,243,754 | detect ultra low dimension real network reduc dimens redund find simplifi pattern high dimension dataset complex network becom major endeavor mani scientif field howev detect dimension latent space challeng necessari generat effici embed use multitud downstream task propos method infer dimension network without need priori spatial embed due abil hyperbol geometri captur complex connect real network detect ultra low dimension far valu report use approach appli method real network differ domain found unexpect regular includ tissu specif biomolecular network extrem low dimension brain connectom close three dimens anatom embed social network internet requir slight higher dimension beyond pave way toward ultra effici dimension reduct find help address fundament issu hing dimension univers critic behavior | D063132 | T017;T091 |
36,243,752 | expiratori high frequenc percuss ventil novel concept improv gas exchang although high frequenc percuss ventil hfpv improv gas exchang concern remain tissu overdistens caus oscil consequ lung damag compar modifi percuss ventil modal creat superimpos high frequenc oscil convent ventil waveform expir ehfpv convent mechan ventil cmv standard hfpv | D003586;D006612 | T061;T047 |
36,243,751 | subcellular partit protein kinas activ reveal function kinom profil protein kinas substrat form signal network partit across subcellular compart facilit critic biolog process subcellular role mani individu kinas elucid comprehens assess synapt subkinom lack studi kinas focus transcript protein andor phospho protein express level provid indirect measur protein kinas activ prior work suggest gene express level good predictor protein function thus assess global serinethreonin protein kinas activ profil synaptosom nuclear cytosol fraction rat frontal cortex homogen use peptid array comparison made fraction demonstr differ overal protein kinas activ upstream kinas analysi reveal list cognat kinas enrich synaptosom fraction compar nuclear fraction identifi mani kinas synapt fraction previous implic compart also identifi kinas littl evid synapt local result show feasibl assess subcellular fraction peptid activ array well suggest compart specif activ profil associ establish novel kinas | D010455;D011494 | T121;T126;T116 |
36,243,750 | microvascular complic identifi specif coronari atherosclerot phenotyp patient type diabet mellitus patient type diabet mellitus tdm consid homogen cohort patient howev specif role diabet microvascular complic dmc determin featur coronari plaqu poor known investig whether presenc dmc may identifi differ phenotyp patient associ specif clinic angiograph optic coher tomographi oct featur differ prognosi | D003324;D003924;D058226 | T031;T047;T046;T020 |
36,243,749 | warm predat risk weak shape size mediat prioriti effect cannibalist damselfli differ hatch date shape intraspecif interact size mediat prioriti effect smpe phenomenon bigger earli hatch individu gain advantag smaller late hatch one howev remain unclear extent smpe affect key environment factor warm predat risk impos top predat studi effect warm low high temperatur predat risk presenc absenc predat cue perch smpe life histori physiolog trait cannibalist damselfli ischnura elegan induc smpe laboratori manipul hatch date creat follow group earli late hatchl rear separ contain mix phenolog group earli late hatchl share contain found strong smpe surviv emerg success highest valu earli larva mix phenolog group lowest valu late larva mix phenolog group neither temperatur predat cue affect smpe two trait life histori trait develop rate mass emerg show smpe affect temperatur predat cue tendenc smpe found protein content high temperatur treatment physiolog trait phenoloxidas activ fat content show fix express across treatment indic decoupl physiolog life histori result underlin smpes trait depend weak affect temperatur predat risk | D063191;D011235 | T054;T204 |
36,243,748 | novel lipid indic risk type diabet mellitus among chines hypertens patient find guangzhou heart studi data limit whether sever easili measur indic independ predictor type diabet mellitus tdm hypertens patient studi aim assess associ hypertriglyceridem waist phenotyp triglycerid glucos tyg index lipid accumul product lap viscer adipos index vai tdm risk hypertens patient | D003924;D006973 | T047 |
36,243,747 | determin boundari lipid sticholysin use tryptophan quench sticholysin pore form toxin produc sea anemon stichodactyla helianthus toxin exert activ form pore sphingomyelin contain membran recognit sphingomyelin sticholysin requir start process pore format sphingomyelin recognit coupl membran bind follow membran penetr oligomer mani featur process known howev extent contact differ kind lipid present membran receiv littl attent delv question use phosphatidylcholin analogu label one acyl chain doxyl moieti known quencher tryptophan emiss present evid contact sticholysin phosphatidylcholin lipid sticholysin oligom sticholysin isotoxin affect differ inclus cholesterol membran furthermor use phosphatidylcholin analog label differ posit structur acyl chain headgroup combin varieti sticholysin mutant also investig depth tryptophan residu sticholysin bilay result indic posit tryptophan residu relat membran normal deeper cholesterol absent membran | D003064;D012615 | T131;T123;T116;T204 |
36,243,746 | synthes realist high resolut retina imag style base generat adversari network util realist imag synthesi base deep learn invalu techniqu develop high perform comput aid diagnosi system protect patient privaci howev train generat adversari network gan imag synthesi remain challeng larg amount data requir train various kind imag featur studi aim synthes retin imag indistinguish real imag evalu efficaci synthes imag specif diseas augment class imbalanc dataset synthes imag valid via imag ture test qualit analysi retin specialist quantit analys amount signal nois ratio vessel efficaci synthes imag verifi deep learn base classif perform ture test show accuraci sensit specif respect sensit repres correct find real imag among real dataset vessel amount averag snr comparison show differ real synthes imag classif perform augment synthes imag outperform everi ratio imbalanc real dataset studi show realist retina imag success generat insignific differ real synthes imag show great potenti practic applic | D007091;D012160 | T023;T066 |
36,243,745 | ecolog factor like driver eye shape colour pattern variat across anthropoid primat extern eye appear across primat speci divers shape colour yet still lack explan driver divers quantifi substanti interspecif variat eye shape colour across primat speci repres extant genera anthropoid primat reassess seri hypothes aim explain ocular variat horizont elong colour across speci heavier bodi weight terrestri locomot associ elong eye outlin speci live closer equat present pigment conjunctiva suggest photoprotect function iris becom bluer speci live away equat ad exist literatur support circadian clock function bluer iris result shift current focus communic ecolog factor drive variat extern eye appear anthropoid primat also highlight possibl similar ecolog factor contribut select blue eye ancestr human popul live northern latitud | D055669;D005123;D005127;D000882 | T023;T015;T032;T070 |
36,243,744 | dynam human milk oligosaccharid earli lactat relat growth appetit trait filipino breastf infant human milk oligosaccharid play key role matur infant gut microbiom immun system hypothes affect growth studi examin tempor chang hmos associ infant growth appetit trait exploratori prospect observ studi filipino mother infant dyad exclus breastf healthi term infant enrol day age mo follow month infant growth measur appetit trait collect visit v mo v mo v mo v mo v mo v mo hmos measur v v v v overal exposur hmo summar area curv baselin month age examin associ measur growth month use linear regress adjust matern age birth infant sex birth weight mode deliveri saw modest associ sever hmos infant growth paramet result suggest specif hmos part proxi milk group defin secretor lewi status may associ head circumfer length increas relev especi popul lower end growth curv identifi hmos associ infant appetit trait indic least cohort chang appetit drive observ associ hmos growthclin trial registr nct | D001942;D008895 | T031;T055;T058;T040 |
36,243,742 | under mechan relationship stress alcohol consumpt regular riski drinker mesa method design random laboratori studi excess alcohol consumpt alcohol use disord aud among lead prevent caus prematur morbid mortal consid major public health concern order reduc individu societ burden excess alcohol use crucial identifi high risk individu earlier stage provid effect intervent prevent progress stress experi import risk factor excess alcohol consumpt aud howev under biolog psycholog mechan still poor understood | D000437 | T048 |
36,243,741 | associ among internet addict lifestyl behavior dental cari among high school student southwest japan internet addict ia negat affect adolesc lifestyl behavior inappropri lifestyl behavior could negat effect dental health cross section studi aim test whether ia indirect associ dental cari unhealthi lifestyl behavior among high school student southwest japan ia character young internet addict test score unhealthi lifestyl behavior cumul count differ lifestyl behavior term unhealthi lifestyl behavior index ulbi dental cari number decay miss fill perman teeth dmft poisson regress linear regress model fit relationship ia exposur ulbi mediat dmft outcom natur indirect effect nie proport mediat ulbi estim perform mediat analysi overal high school student includ ia observ particip associ larger dmft ulbi signific mediat associ ia dmft nie incid rate ratio confid interv proport mediat dental cari common cohort high school student ia partial explain student unhealthi lifestyl behavior | D003731;D000082424 | T047;T048;T033 |
36,243,740 | characteris ethnic differ dna methyl uk resid south asian european ethnic differ non communic diseas risk describ individu south asian european ethnic partial explain genet known risk factor dna methyl one underexplor mechan may explain differ diseas risk current littl knowledg dna methyl vari south asian european ethnic studi characteris differ blood dna methyl individu self report european south asian ethnic two uk base cohort southal brent revisit born bradford dna methyl differ ethnic widespread throughout genom n cpg site site test specif associ attribut ethnic differ cell composit fewer effect attribut smoke genet variat ethnic associ cpg site enrich ewa catalog phenotyp includ metabolit work highlight need consid ethnic divers epigenet research | D019175;D044465 | T098;T044 |
36,243,739 | real time monitor cold ca depend transcript modul ncx inhibitor real time monitor cellular temperatur respons import techniqu thermal biolog drug develop recent studi identifi na ca exchang ncx depend ca influx transduc cold signal circadian clock mammalian cultur cell find rais idea cellular respons cold signal analyz monitor clock gene express found per per regul cultur c compar c rat fibroblast order monitor cold ca depend transcript live cell develop luciferas base real time report system use per promot per promot ca camp respons element cre nfat bind element found benzyloxyphenyl ncx inhibitor kb r sn sea ym inhibit cold induct per studi establish real time monitor system cold ca signal appli evalu drug | D002118;D019831 | T121;T123;T116;T196 |
36,243,736 | barrier facilit hiv care continuum among adult live hiv high incom countri scope review protocol life expect peopl live hiv increas advanc antiretrovir treatment continu long term therapi health care peopl live hiv gain import howev estim proport peopl live hiv access treatment viral suppress unsatisfactori therefor necessari build strategi improv treatment continu identifi barrier facilit affect hiv care continuum enabl conduct scope review explor barrier facilit relat care continuum high incom countri adult live hiv | D015658;D007182 | T078;T047;T081 |
36,243,734 | singl molecul track nodal lefti live zebrafish embryo support hinder diffus model hinder diffus model postul movement signal molecul embryo affect tissu geometri bind mediat hindranc effect direct demonstr vivo visual extracellular movement bind individu molecul activ inhibitor signal pair nodal lefti live develop zebrafish embryo use reflect light sheet microscopi observ diffus coeffici molecul high extracellular caviti wherea mobil reduc bound fraction high within cell cell interfac counterintuit molecul nevertheless accumul caviti attribut geometri extracellular space agent base simul find nodal larger bound fraction lefti show bind time ten second togeth measur simul provid direct support hinder diffus model yield insight nanomet micromet scale mechan lead macroscop signal dispers | D055457;D015027 | T123;T116;T013 |
36,243,733 | associ serum mitokin level outcom stabl copd observ prospect studi mitokin humanin hn gdf fgf produc result mitochondri dysfunct may major role chronic inflamm malnutrit exercis capac peopl copd except gdf studi subject lack total patient stabl copd smoker without copd enrol assess serum mitokin level clinic characterist baselin record moder sever exacerb next month baselin serum hn p gdf p level higher copd group high hn level independ associ high risk exacerb hre ci p malnutrit ci p mwd ci p futur moder hr ci p sever exacerb hr ci p high gdf level associ hre ci p mwd ci p predict desatur mwt ci p high fgf level associ hre ci p predict futur sever exacerb hr ci p mitokin level higher patient copd smoker without copd associ import clinic outcom exercis capac copd exacerb among mitokin hn show strongest associ copd may serv futur risk biomark diseasetri regist nct | D044342;D029424 | T047 |
36,243,731 | gut microbiom metabolom dataset collect curat resourc integr meta analysi integr analysi microbiom metabolom data obtain human fecal sampl promis avenu better understand interplay bacteria metabolit human gut health diseas howev acquir process unifi dataset multipl sourc daunt challeng task present public avail simpl use curat dataset collect pair fecal microbiom metabolom data multipl cohort data resourc allow research easili obtain multipl fulli process integr microbiom metabolom dataset facilit discoveri univers microb metabolit link benchmark various microbiom metabolom integr tool compar newli identifi microb metabolit find publish dataset | D000069196 | T007;T001 |
36,243,729 | gabb global dataset alpin breed bird ecolog trait alpin ecosystem repres vari climat veget structur global potenti support rich function divers avian communiti high mountain habitat speci signific threat climat chang anthropogen factor yet global databas alpin bird exist mountain system lack basic inform speci breed alpin habitat status trend potenti cryptic divers ie sub speci distribut address critic knowledg gap combin publish literatur region monitor scheme expert knowledg often inaccess data defici mountain rang develop global list alpin breed bird speci associ distribut select ecolog trait dataset compil alpin breed record bird repres extant speci cover major mountain region across contin exclud antarctica global alpin breed bird dataset gabb essenti resourc research ecolog evolutionari factor shape alpin communiti well document valu high elev climat sensit habitat conserv biodivers | D001717;D017753 | T012;T082;T070 |
36,243,728 | prognost valu arachidon acid metabol breast cancer integr bioinformat second caus cancer death women breast cancer becom worldwid prioriti previous studi base tumour cell line demonstr arachidon acid aa metabolit promot cancer develop howev recent studi base tumour microenviron reveal antitumour effect aa metabol therefor essenti reevalu elucid effect aa metabol breast cancer | D001943 | T191 |
36,243,727 | dataset parent child hyperscan function near infrar spectroscopi record term hyperscan refer simultan record multipl individu brain activ methodolog hyperscan allow investig brain brain synchroni despit promis techniqu limit number public avail function near infrar spectroscopi fnir hyperscan record paper report dataset fnir record prefront cortic pfc activ mother child dyad father child dyad data record parent child dyad particip experi two session passiv video attent task free play session dyadic metadata parent psycholog trait behaviour annot play session inform video stimuli complement dataset fnir signal describ dataset present use design implement test novel fnir analysi techniqu new hyperscan analysi tool well investig pfc activ particip differ age engag passiv view task activ interact task | D001931;D019265 | T059;T062;T060 |
36,243,726 | mrnas encod neurodevelopment regul equal n methyladenosin stoichiometri drosophila neuroblast neuron n methyladenosin preval intern mrna modif metazoan particular abund central nervous system extent dynam regul whether contribut cell type specif mrna metabol nervous system howev larg unknown address knowledg gap map measur mrna decay neural progenitor neuroblast neuron drosophila melanogast larval brain identifi target novel preferenti encod regul neuroblast prolifer cell fate specif synaptogenesi comparison neuroblast neuron transcriptom reveal stoichiometri larg uniform find evid neuroblast specif neuron specif modif stoichiometri constant target signific less stabl neuroblast neuron potenti due independ stabil neuron use vivo quantit imag target protein mettl methyltransferas null brain ythdf reader overexpress brain assay metabol effect target protein level decreas mettl null brain increas ythdf overexpress brain support previous propos model enhanc translat target mrnas conclud direct regul mrna stabil drosophila neurogenesi rather deposit neurodevelopment transcript intrins low stabil order augment protein output | D004330;D004331 | T204 |
36,243,725 | adolesc onset depress associ alter social function middl adulthood depress sensit period social develop may consequ extend well beyond mental health far adulthood studi compar social function adult adolesc onset depress age adult onset depress age particip adult femal age experienc major depress adult function outcom marit status divorc number children year educ employ status household incom depend welfar obes particip depress adolesc less like get marri children like lower household incom depress adolesc may associ broader function outcom impact individu societi may mitig intervent effect polici | D003863;D000083505 | T054;T184;T048;T033 |
36,243,724 | choroid plexus door blood brain tissu type plasminogen activ vascular compart serin proteas tissu type plasminogen activ tpa promot fibrinolysi justifi clinic use vasculo occlus diseas accumul evid show circul tpa endogen exogen also control brain physiopatholog process like cerebrovascular reactiv blood brain barrier bbb homeostasi inflamm neuron fate whether occur direct action parenchym cell andor indirect via barrier blood central nervous system cns remain unclear postul vascular tpa reach brain parenchyma via blood cerebrospin fluid barrier bcsfb reli choroid plexus cp epitheli cell cpec | D002831;D010959 | T121;T023;T126;T116 |
36,243,723 | pericyt take degrad synuclein succumb apoptosi cellular stress parkinson diseas pd characteris progress loss midbrain dopaminerg neuron presenc aggreg synuclein syn pericyt microglia two non neuron cell contain syn human brain howev role diseas process poor understood pericyt found surround capillari brain import maintain blood brain barrier control blood flow mediat inflamm studi primari human brain pericyt microglia expos two differ synuclein aggreg inflammatori respons assess use immunocytochemistri cytometr bead array proteom profil cytokin array kit fix flow cytometri use investig uptak subsequ degrad syn pericyt found two syn aggreg devoid inflammatori cytotox action human brain deriv pericyt microglia although syn induc inflammatori respons pericyt effici take degrad syn lysosom pathway ubiquitin proteasom system furthermor pericyt expos ubiquitin proteasom inhibitor mg syn aggreg profound cytotox product reactiv oxygen speci result apoptosi result suggest observ accumul syn pericyt human pd brain like play role pd pathogenesi perhap caus cerebrovascular instabl condit cellular stress | D010300;D051844 | T047;T123;T116 |
36,243,722 | heterozyg missens variant ywhag gene caus development epilept encephalopathi chines famili development epilept encephalopathi dee heterogen group sever disord character earli onset refractori seizur development slow regress genet variat signific caus chang de novo variant increas number candid gene found causal ywhag gene one gene report caus development epilept encephalopathi dee report heterozyg missens variant cg prh ywhag gene caus earli onset epilepsi development delay chines famili | D004827;D014635 | T121;T047;T109;T033 |
36,243,721 | genet variant associ psychiatr disord enrich epigenet activ site lymphoid cell multipl psychiatr disord associ abnorm innat adapt immun system role abnorm pathogenesi whether driven psychiatr risk variant remain unclear test enrich gwas variant associ multipl psychiatr disord cross disord tran diagnost risk specif disord cis diagnost risk regulatori element immun cell use three independ epigenet dataset repres multipl organ system immun cell subset tran diagnost cis diagnost risk variant schizophrenia depress enrich epigenet activ site brain tissu lymphoid cell especi stimul cd cell evid enrich either tran risk cis risk variant schizophrenia depress myeloid cell suggest possibl model environment stimuli activ cell unmask effect psychiatr risk variant contribut pathogenesi mental health disord | D001523;D012559 | T048 |
36,243,720 | predict osteoporosi osteopenia routin comput tomographi lumbar spine differ region interest aim investig util hounsfield unit hu obtain differ region interest opportunist lumbar comput tomographi ct predict osteoporosi coupl data dual energi x ray absorptiometri dxa | D001851;D010024 | T047 |
36,243,718 | vivo fluoresc imag success preclin imag pave way clinic applic advanc diagnost imag provid unpreced opportun detect diseas earli stage high reliabl diagnost imag also crucial monitor progress remiss diseas thus often central basi therapeut decis make current sever diagnost imag modal comput tomographi magnet reson imag positron emiss tomographi among other routin use clinic present advantag limit vivo near infrar nir fluoresc imag recent emerg attract imag modal combin low cost high sensit relat safeti preclin tool use investig diseas mechan test novel diagnost therapeut prior clinic use howev limit depth tissu penetr major challeng effici clinic use therefor current clinic use fluoresc imag limit applic imag guid surgeri tumor retin angiographi use fda approv dye progress fluorophor develop nir imag technolog hold promis extend clinic applic oncolog cardiovascular diseas plastic surgeri brain imag among other nanotechnolog expect revolution diagnost vivo fluoresc imag target deliveri nir fluoresc probe use antibodi conjug review discuss latest advanc vivo fluoresc imag technolog nir fluoresc probe current futur clinic applic | D005456;D025321 | T061;T130 |
36,243,716 | deep learn base behavior profil rodent stroke recoveri stroke research heavili reli rodent behavior assess under diseas mechan treatment efficaci although function motor recoveri consid primari target outcom test rodent still poor reproduc often unsuit unravel complex behavior injuri | D002545;D000077321;D020521 | T047;T046;T066 |
36,243,715 | identif acet acid sensit strain biosensor base screen saccharomyc cerevisia crispri librari acet acid toler crucial develop robust cell factori convers lignocellulos hydrolys typic contain high level acet acid screen mutant growth medium acet acid attract way identifi sensit variant provid novel insight complex mechan regul acet acid stress respons | D015374;D029701 | T059;T075;T116 |
36,243,714 | enhanc linalool product saccharomyc cerevisia util isopentenol util pathway linalool monoterpenoid also vital silvichem commerci applic cosmet flavor ingredi medicin regul mevalon mva pathway metabol flux common strategi engin saccharomyc cerevisia effici linalool product howev metabol regul mva pathway complex involv competit central carbon metabol result limit content target metabolit | D008798;D012441 | T109;T123;T004 |
36,243,713 | discrimin cross reactiv polyclon igg respons sar cov variant concern exist assay measur antibodi cross reactiv differ sar cov spike protein variant lack discriminatori power provid insight level individu clone use mass spectrometri base approach abl monitor individu donor igg clonal respons follow sar cov infect monitor plasma clonal igg profil donor experienc infect either wild type wuhan hu virus one voc alpha beta gamma donor chart full plasma igg repertoir well igg repertoir target sar cov spike protein trimer voc antigen plasma donor contain numer anti spike igg antibodi account almost igg antibodi voc specif wherea other recogn multipl even voc show polyclon respons clone exhibit distinct cross reactiv also distinct virus neutral capac observ support need person look antibodi clonal respons infecti diseas | D000086382;D000086402 | T047;T067;T005 |
36,243,712 | comparison effect melatonin dexmedetomidin gabapentin reduct postop pain anxieti follow laminectomi random clinic trial studi aim compar effect melatonin dexmedetomidin gabapentin postop pain anxieti follow laminectomi | D014151;D020927;D008550 | T121;T125;T109;T039 |
36,243,711 | tise mediat sonodynam checkpoint blockad combin immunotherapi hypox pancreat cancer pancreat cancer remain among preval aggress form cancer immunotherapeut treatment strategi shown promis affect patient benefit intervent limit insuffici tumor infiltr activ cell | D018414;D010190 | T191;T025 |
36,243,710 | influenc total disc arthroplasti mobidisc prosthesi lumbar spine pelvic paramet prospect vivo biomechan studi minimum year follow studi examin impact mobidisc implant spinopelv paramet particular focus preserv lumbar lordosi segment lordosi sl treat adjac segment | D001186;D008141;D013123;D059145 | T061;T047;T074 |
36,243,709 | self collect versus medic collect sampl human papillomavirus test among women lago nigeria compar studi evalu feasibl perform self collect vagin swab sampl hpv screen among women lago nigeria | D052685;D030361;D002583 | T191;T047;T005 |
36,243,708 | mir p sabotag lncrna malat stabil repress chondrocyt pyroptosi reliev cartilag injuri osteoarthr osteoarthr oa preval inflammatori joint disord microrna mirna increas involv oa | D035683;D010003;D062085 | T047;T123;T114 |
36,243,707 | associ lipid profil report edentul elder popul data china health retir longitudin studi relationship lipid profil periodont report howev associ lipid paramet edentul unclear studi aim investig associ lipid profil report edentul elder popul use nation cohort | D002784;D012179 | T121;T109;T123;T033 |
36,243,706 | co express network analysi identifi potenti candid hub gene sever influenza patient need invas mechan ventil influenza contagi diseas affect peopl age link consider mortal epidem occasion outbreak moreov effect immunolog biomark need elucid aetiolog prevent treat sever influenza herein aim evalu key gene link diseas sever influenza patient need invas mechan ventil imv three gene microarray data set gse gse gse blood sampl influenza patient made avail gene express omnibus geo databas gse gse data set combin creat train set hub indic imv patient sever influenza determin use differenti express analysi weight correl network analysi wgcna train set receiv oper characterist curv roc also use evalu hub gene test set diagnost accuraci differ immun cell infiltr level express profil correl hub gene marker examin use singl sampl gene set enrich analysi ssgsea | D053263;D007251 | T047;T044 |
36,243,705 | comput aid diagnost classifi chest x ray imag use deep ensembl learn nowaday doctor radiologist overwhelm huge amount work led effort design differ comput aid diagnosi system cad system aim accomplish faster accur diagnosi current develop deep learn big opportun develop new cad paper propos novel architectur convolut neural network cnn ensembl classifi chest x ray crx imag four class viral pneumonia tuberculosi covid healthi although comput tomographi ct best way detect diagnos pulmonari issu ct expens crx furthermor crx common first step diagnosi import accur earli stage diagnosi treatment | D000086382;D000077321 | T047;T066;T067 |
36,243,704 | effect physiotherapeut scoliosi specif exercis patient mild juvenil scoliosi combin retrospect prospect analysi therapeut effect physiotherapeut scoliosi specif exercis psse mild juvenil idiopath scoliosi jis patient | D012600 | T047 |
36,243,703 | incid type restrict practic use nurs home ireland use restrict practic rp care set may sometim warrant also conflict human right research date focus primarili physic chemic rp howev form also use better understand practic inform rp reduct studi describ incid type rp use report nurs home ireland | D014150;D009735 | T121;T093;T073;T039 |
36,243,702 | antitumor activ protein kinas inhibitor deoxyribofuranosyl tetrabromo h benzimidazol breast cancer cell line protein kinas ck pim involv cell prolifer surviv cell cycl drug resist found overexpress virtual type human cancer includ breast cancer studi investig antitumor activ deoxynucleosid deriv protein kinas inhibitor compound deoxyribofuranosyl tetrabromo h benzimidazol k also term tdb inter alia ck pim breast cancer cell line mda mb mcf sk br | D000970;D001943 | T121;T109;T191 |
36,243,701 | social sexual live black sexual minor men year age older south africa black sexual minor men smm age older repres hiv studi sub saharan africa despit increas risk hiv infect contribut potenti onward hiv transmiss better understand social sexual live older black south african smm conduct depth interview smm year old | D015658;D000072339 | T098;T047 |
36,243,700 | listeria monocytogen bacteremia mimick system metastasi adren cancer case report listeria monocytogen causat agent food poison also known caus invas diseas bacteremia mening enceph neonat elder immunocompromis patient howev clinic cours multi organ dissemin diseas secondari bacteremia rare report | D000310;D016470;D008089;D008088 | T191;T007;T047 |
36,243,699 | trust base servic innov municip home care longitudin mix method studi scandinavia various public reform initi enhanc trust healthcar servic public sector general studi explor experi two step servic innov project municip home care norway coin trust model tm aim develop altern purchas provid split pps enhanc employe motiv user satisfact citizen trust pps preval model norway sinc littl empir research trust base altern pps healthcar overal object studi explor facilit barrier trust base servic innov municip homecar develop framework support implement tm | D006699;D035502 | T054;T058 |
36,243,698 | use mobil data collect system within larg scale epidemiolog field trial find lesson learn vector control trial iquito peru vector born diseas among burdensom infecti diseas worldwid high burden health system develop region tropic mani diseas vector control reduc human bite rate arthropod popul remain primari strategi prevent new vector control intervent intend market public health channel must assess world health organ public health valu use data generat larg scale trial integr epidemiolog endpoint human health impact phase iii trial typic follow larg number studi subject meet necessari power requir detect signific differ treatment arm therebi generat substant complex dataset data often gather direct field resourc poor set lead challeng effici data report andor qualiti assur advanc technolog mobil data collect mdc system implement mani studi overcom challeng describ develop implement mdc system random cluster placebo control clinic trial evalu protect efficaci spatial repel intervent reduc human infect aed born virus abv urban set iquito peru well data manag system support discuss benefit remain capac gap key lesson learn use mdc system context detail | D000330;D003715 | T047;T204 |
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