PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,244,711 | vascular bone flap treatment kienbck diseas mani treatment kienbck diseas lunat revascular procedur provid direct mechan revers process osteonecrosi owe redund blood suppli distal radius carpus pedicl flap versatil solut patient bone loss intact cartilag advent free vascular flap indic lunat revascular procedur expand flap use articular cartilag compromis suitabl option restor nativ anatomi patient previous thought unreconstruct diseas | D002358;D012667;D010020 | T046;T023;T024;T047 |
36,244,710 | osteotomi core decompress denerv treatment kienbck diseas various osteotomi core decompress denerv demonstr favor outcom treatment kienbck diseas given rariti diseas dearth high level compar studi direct treatment articl author review current literatur surround techniqu provid summari recommend procedur choic | D010020;D011884 | T047;T046;T023 |
36,244,709 | algorithm approach treatment kienbck diseas algorithm rational describ reflect surgic experi challeng disord compar public algorithm evolv treatment larg volum patient kienbck diseas referr practic howev limit manag found logic effect within scope experi treatment guidelin specialti whole evolv understand etiolog abil quantifi efficaci improv | D012667;D010020 | T023;T046;T047 |
36,244,708 | classif radiograph character kienbck diseas robert kienbck describ radiograph chang associ idiopath lunat osteonecrosi radiograph progress eponym condit well describ progress normal radiograph lunat sclerosi lunat collaps proxim capit migrat scaphoid flexion pancarp arthriti diagnos earli stage diseas without radiograph chang present challeng imag modal evolv diagnosi becom possibl mri although numer classif system exist lichtman classif bain arthroscop grade system becom wide use articl outlin avail classif system aim highlight may use patient manag | D012667;D010020;D021361 | T023;T046;T047 |
36,244,707 | pathoanatomi biomechan kienbck diseas kienbck diseas kd involv osseous vascular chondral aspect lunat wrist present theori etiolog pathogenesi condit base basic scienc model semin literatur person case experi kinemat observ kienbck wrist three phenotyp kienbck diseas occur tend differ morpholog rate progress diseas pattern lunat fractur kd well recogn differ fractur type occur dynam assess kienbck wrist allow assess complex kinemat kd diseas onset progress requir perfect storm risk factor | D012667;D010020 | T023;T046;T047 |
36,244,706 | kienbck diseas clinic present epidemiolog histor perspect year pass sinc kienbck first publish semin descript lunat osteonecrosi improv imag technolog surgic techniqu provid better understand kienbck diseas pathogenesi treatment howev precis etiolog natur histori optim treatment remain controversi futur studi examin genet behind diseas larg scale prospect studi compar treatment option repres next step improv understand rare complex phenomenon | D012667;D010020 | T023;T046;T047 |
36,244,705 | vascular suppli wrist vascular anatomi wrist vital develop multipl disord carpus understand vascular network may prevent iatrogen injuri blood suppli use surgeon vascular bone graft multipl surgic techniqu take advantag vascular network articl review blood suppli distal radius ulna carpal bone clinic implic | D002348;D014953 | T023;T029 |
36,244,704 | pathophysiolog avascular necrosi avascular necrosi complic multifactori diseas potenti devast consequ although under root caus lack appropri vascular perfus affect bone often vari patient specif anatom specif injuri specif predisposit factor general fall categori direct vascular disrupt intravascular obliter extravascular compress initi stage diseas insidi symptomat edemat bone marrow progress subchondr collaps subsequ degen arthriti although much current literatur focus femor head common area occurr includ proxim humerus knee carpus low incid rate carpal avascular necrosi pose challeng establish adequ power control base valid treatment option therefor optim surgic manag remain continu debat among hand surgeon appreci expect fractur heal physiolog may help guid futur investig carpal specif caus avascular necrosi | D002348;D010020 | T023;T046;T047 |
36,244,695 | manag menopaus symptom qualiti life menopaus transit women experi bothersom symptom around time menopaus may negat impact qualiti life prompt seek treatment menopaus hormon therapi histor treatment choic howev medic contraind person prefer nonhormon therapi prompt evalu rang nonhormon pharmacolog non pharmacolog therapi review provid updat focus latest evid base approach manag bothersom symptom menopaus | D019584;D011788 | T078;T184 |
36,244,693 | use patient report outcom assess diabet outcom treatment diabet complex overwhelm patient demand persist attent lifestyl manag adher medic monitor side effect drug manag devic glucos monitor andor insulin infus therefor understand patient report outcom pros provid direct insight patient experi diabet crucial optim diabet managementthi review provid overview common use pro questionnair assess differ aspect diabet manag | D015190;D003922 | T047;T060 |
36,244,691 | symptom late onset hypogonad men small percentag older men hypogonad appar reason age condit call late onset hypogonad condit accompani symptom especi sexual symptom notabl decreas libido testosteron treatment men late onset hypogonad improv aspect sexual function also mood depress symptom self report walk abil testosteron treatment would expect improv similar symptom men unequivoc hypogonad | D007006;D007989 | T047;T041;T184;T033 |
36,244,690 | qualiti life patient adren insuffici patient adren insuffici despit standard glucocorticoid replac therapi continu experi report impair self perceiv health status qualiti life review describ qualiti life patient popul summar determin qualiti life base previous survey base studi clinic trial addit new emerg data still ongo coronavirus diseas pandem also review present articl | D000309;D005938 | T039;T047;T109;T125 |
36,244,689 | patient report outcom endoscop endonas skull base surgeri function outcom qualiti life patient feedback relat chosen treatment approach skull base surgeri becom subject interest focus research recent year current advanc endoscop optic imag technolog surgic precis radic lower periop morbid associ skull base surgeri push toward higher focus patient report outcom pros critic ensur offer treatment plan approach align patient prefer expect addit surgeon best clinic judgment experi pros repres view reflect patient thought perspect condit manag option without input interpret surgeon pro data enabl patient opportun learn experi perspect patient input empow patient becom activ particip decis make process differ stage care depth pro evalu requir specif valid tool score system name patient report outcom measur prom tool review discuss current avail skull base relat pros assess tool use captur futur trend import topic infanc | D011788;D019291 | T078;T029 |
36,244,688 | evalu impact acromegali qualiti life acromegali substanti negat impact qualiti life qol review aim discuss impact acromegali qol clinic perspect well patient perspect furthermor aim evalu use patient report outcom measur prom acromegali prom aid decis make recommend present review base recent clinic evid impact acromegali qol combin author clinic experi treat patient acromegali recommend patient center approach consid treatment decis integr convent biochem outcom tumor control comorbid treatment complic prom includ qol measur integr approach seem effect treat comorbid improv patient report outcom critic mani patient achiev biochem tumor control comorbid impair qol may remit even full biochem control achiev | D000172 | T047 |
36,244,687 | evalu patient report outcom cush syndrom import patient perspect diseas increas gain traction among clinic investig clinician patient report outcom pros pertain patient health qualiti life function status associ health care treatment report direct patient without interpret clinician articl review pros relat sign symptom health relat qualiti life comorbid activ cush syndrom cs cs treatment surgeri radiotherapi medic therapi explor long term outcom set remiss persist recurr popul | D003480 | T047 |
36,244,685 | new nhs prehospit major incid triag tool mimm mitt triag key principl effect manag major incid process patient prioritis basi clinic acuiti howev work publish last decad demonstr exist method triag perform poor tri identifi patient need life save intervent result review major incid triag initi nhs england remit determin optimum way triag patient age major incid uk articl describ output review chang undertaken uk major incid triag introduct new nhs major incid triag tool spring | D014218;D054527 | T098;T061;T051 |
36,244,651 | bmgr respond sucros glucos express tachykinin relat peptid secret enteroendocrin cell regulatori hormon known tachykinin relat peptid trps identifi brain gut peptid insect dietari compon mulberri leav includ glucos induc secret trps bombyx mori midgut howev sensori molecul recogn compound still unknown identifi gustatori receptor bmgr sucros glucos receptor use ca imag immunostain reveal bmgr express midgut also brain addit bmgr express found co local trp express cell midgut enteroendocrin cell eec brain neurosecretori cell nscs furthermor dietari nutrient food intak result increas trp level hemolymph silkworm larva result provid signific circumstanti evid involv sucros glucos receptor bmgr elicit trp secret midgut eec brain nscs | D005947;D012831 | T121;T109;T123;T204 |
36,244,650 | regul track bidirect signal semaphorin wnt signal drosophila motor axon guidanc track receptor tyrosin kinas otk shown play import role drosophila motor axon pathfind result biochem genet interact previous suggest otk act compon semaphorin aplexin sema aplexa signal embryon motor axon guidanc show otk bind wnt famili member wnt wnt common receptor frizzl fz howev molecular mechan under motor axon guidanc function otk remain elus conclud otk mediat forward revers signal requir intersegment nerv b isnb motor axon pathfind also demonstr loss two copi sema synergist enhanc bypass phenotyp observ otk mutant furthermor amorph wnt mutat result increas prematur branch phenotyp loss fz function caus frequent inabl isnb motor axon defascicul specif choic point consist previous studi wnt mutant axon often defect recogn target muscl interest bypass phenotyp otk mutant robust suppress loss function mutat wnt wnt fz contrast total isnb defect otk increas loss function allel wnt wnt fz find indic otk may particip crosstalk sema aplexa wnt signal pathway therebi contribut isnb motor axon pathfind target recognit | D039961;D029721 | T123;T116 |
36,244,638 | structur character anti fatigu activ acid polysaccharid panax ginseng c meyer panax ginseng c meyer tradit chines herbal medicin use china year tradit effect invigor vital main reflect anti fatigu howev due difficulti identif polysaccharid structur report homogen ginseng polysaccharid molecular mechan anti fatigu effect remain explor | D005894 | T002 |
36,244,604 | pyridinium function chitosan effici elimin methyl orang cr vi pyridinium function chitosan pcs high yield facil solvotherm obtain reaction chitosan n dinitrophenyl pyridinium chlorid morpholog physic chemic properti pcs test various techniqu sorption behavior toward methyl orang mo cr vi systemat investig pseudo second order kinet langmuir equat well fit sorption kinet isotherm respect thermodynam analys reveal spontan endotherm sorption two contamin pcs exhibit high sorption capac mgg mo mgg cr vi k superior sorption perform pcs mo ascrib ion exchang intermolecular hydrogen bond electrostat interact sorption pcs cr vi main driven electrostat forc reduct ion exchang moreov pcsexceed origin capac five cycl high sorption capac high reusabl make pcs excel sorbent candid toward anion contamin | D048271;D014874 | T121;T109;T131 |
36,244,587 | circul microrna relat lipid metabol solid tissu mainten morpholog associ mortal elder twin lifespan human vari great individu aim explor biolog role mirna may old age mortal variat circul mirna measur plasma monozygot twin pair year age mortal analys appli use cox regress surviv analys linear regress analys lifespan general nomin signific mirna main upregul shorter lifespan cox analysi upregul linear regress analysi upregul total mirna associ mortal nomin signific level p surviv analysi mirna pass fdr adjust level signific seven mirna hsa mir p hsa mir p hsa mir b p hsa mir p hsa let p hsa mir hsa mir nomin signific across two linear twin pair analys cox analysi pathway analys nomin signific mirna individu level analys result two nomin signific associ reactom pathway unadjust p negat regul fgfr signal neurotransmitt receptor bind downstream transmiss postsynapt cell two signific associ kegg pathway linol acid metabol toxoplasmosi addit pathway analys result previous studi support mirna link mortal age year older play role lipid metabol tissu mainten morpholog | D000074166;D035683 | T123;T114 |
36,244,586 | leav scutellaria baicalensi georgi attenu brain age galactos induc rat via regul glutam metabol nrf signal pathway present studi aim evalu anti age effect leav scutellaria baicalensi georgi lsbg investig mechan purpos sd rat receiv galactos gal subcutan gkg lsbg intragastr gkg gkg week behavior test conduct evalu cognit function rat result show memori impair revers lsbg metabolom cortex hippocampus use investig potenti mechan metabolit cortex metabolit hippocampus age rat alter respect addit result show content key metabolit activ enzym glutam metabol downstream metabol glutathion metabol could regul lsbg addit protein nrf signal pathway analyz western blot protein express level nrf gclc ho nqo signific regul lsbg cortex hippocampus anti age effect lsbg involv regul glutam metabol nrf signal pathway | D031364;D005690 | T109;T123;T002 |
36,244,585 | determin gene express human liver impact age sex xenobiot metabol need character potenti suscept older adult toxic environment chemic exposur liver xenobiot metabol enzym xmes play import role detoxifi elimin xenobiot examin global gene express liver young year old year men women differenti express gene deg identifi use two way anova p identifi deg young old group men women respect minor number total number gene overlap gene age increas decreas pathway involv inflamm intermediari metabol respect age led numer chang express xme gene gene known control express gene cytochrom ps activ examin increas activ cypa cypc enzym old group also identifi sex depend gene numer young group old group includ chang xmes studi indic liver age human compar younger adult exhibit chang xmes may lead differ metabol xenobiot | D015262;D003577 | T126;T131;T123;T116 |
36,244,584 | ergothionein prospect anti age compound healthi age crucial process need highlight affect qualiti lifespan increas oxid stress along age major factor relat age associ diseas especi neurodegen disord antioxid rich diet proven play signific role age process target age mechan could worthwhil approach improv health standard ergothionein egt hydrophil compound specif transport known octn shown exert anti age properti addit antioxid effect egt report anti senesc anti inflammatori anti neurodegen properti review aim defin pivot role egt major signal pathway age insulininsulin like growth factor igf signal ii sirtuin sirt mammalian target rapamycin complex mtor pathway review discuss evid egt neurodegener therapeut context various model organ provid new insight improv health conclus ergothionein rich diet may benefici prevent age relat diseas result healthi age popul | D004880 | T109;T123 |
36,244,582 | super resolut imag quantit analysi microtubul array model neuron show epothilon increas densiti decreas length straight microtubul axon like process microtubul essenti develop neuron regul structur plastic microtubul also provid structur basi long distanc transport cargo various factor influenc organ dynam neuron microtubul disturb microtubul regul thought play central role neurodegen diseas howev imag quantit assess microtubul organ dens pack neuron process challeng develop super resolut techniqu combin use nanobodi offer new possibl visual microtubul neurit high resolut combin recent develop comput analysi tool allow autom quantif neuron microtubul organ high precis implement three dimension dna paint point accumul nanoscal topographi singl molecul local microscopi smlm techniqu allow us acquir array microtubul lattic axon model neuron neuron differenti pc cell dendrit primari neuron quantit analysi microtubul organ use open sourc softwar packag smlm imag filament extractor sifn found treatment nanomolar concentr microtubul target drug epothilon epod increas microtubul densiti axon like process model neuron shift microtubul length distribut shorter one mean microtubul length without epod epod also observ signific decreas microtubul straight epod treatment chang microtubul densiti consist live cell imag measur ensembl microtubul dynam use previous establish fluoresc decay photoactiv fdap assay comparison determin organ microtubul array dendrit primari hippocamp neuron observ dendrit microtubul similar length distribut straight compar microtubul axon like process neuron cell line data show super resolut imag microtubul follow algorithm base imag analysi repres power tool quantit assess chang microtubul organ neuron process use determin effect microtubul modul condit also provid evid approach robust appli neuron cell line primari neuron incorpor label tubulin anti tubulin antibodi stain | D008870;D001369 | T026 |
36,244,581 | central role tau alzheim diseas neurofibrillari tangl matur induct cell death tau protein one two hallmark protein alzheim diseas ad togeth amyloid protein contrast abnorm phosphoryl p also found non ad tauopathi ad p main compon intraneuron neurofibrillari tangl result aggreg abnorm phosphoryl fold review discuss role p patholog alzheim diseas consid neuropatholog biochem cellular anim model clinic find discuss relationship p ad relat protein transact respons dna bind protein tdp light current state knowledg conclud p aggreg known primari age relat tauopathi part may repres prerequisit develop ad rather downstream effect toxic howev well tdp patholog appear acceler accumul propag p patholog initi ultim lead full blown pictur ad context seed induc granulovacuolar degener gvd ad typic lesion activ necrosom requir execut necroptosi program form cell death found moreov necrosom exhibit gvd associ decreas neuron densiti thus specul p patholog major driver neuron loss ad via gvd mediat necroptosi overal p seem play central role ad appear constitut prerequisit ad develop acceler co factor would fit probabilist model ad presenc sever respect co factor tdp other contribut separ ad pathogenesi probabilist factor certain weight | D000544;D024801 | T047;T048 |
36,244,580 | ligustrazin exert neuroprotect effect via circmir cxcr axi inhibit cell apoptosi inflamm cerebr ischemiareperfus injuri ligustrazin tradit chines herbal medicin long use treat cerebr ischem disord howev molecular mechan ligustrazin cerebr ischemiareperfus ir damag clear elucid aim studi examin neuroprotect mechan ligustrazin cerebr ir | D002545;D035683;D018696;D015427 | T047;T046;T037;T121;T123;T114;T169 |
36,244,543 | n acylethanolamin acid amidas naaa exacerb psoriasi inflamm enhanc dendrit cell dcs matur psoriasi incur autoimmun diseas affect world popul limit understand pathogenesi hinder develop therapi diseas herein report n acylethanolamin acid amidas naaa cystein enzym catalyz hydrolysi fatti acid ethanolamid fae upregul psoriasi patient imiquimod imq induc mous model psoriasi upregul naaa contribut progress psoriasi via enhanc dendrit cell dcs matur transgen express naaa mice acceler develop psoriasi wherea genet ablat naaa local administr naaa inhibitor f amelior psoriasi naaa express dendrit cell dcs macrophag cell keratinocyt play critic role psoriasi develop addit result show naaa degrad palmitoylethanolamid pea reduc pea ppar mediat dissoci nf b p sirtuin sirt subsequ repress acetyl p regul il product decreas il lead matur dcs thus promot develop psoriasi result provid new insight pathophysiolog mechan psoriasi identifi naaa novel target treatment psoriasi | D016753;D011565 | T047;T116;T129 |
36,244,541 | hyperbranch polyamidoamin chitosan polyelectrolyt gel crosslink polyacryl acid algin remov anion dye difficult treat wastewat discharg print dye industri pose environment risk three dimension porous structur exhibit excel dye adsorpt properti studi chitosan cts introduc situ polyamidoamin pamam composit gel contain sodium algin sa cts situ grown pamampolyacryl acid scpp gn n prepar control structur use semi dissolut acidif sol gel transit method sd sgt owe stronger mechan strength larger specif surfac area scpp g composit gel higher stabil greater adsorpt capac dye maximum adsorpt capac mgg rose bengal rb mgg sunset yellow sy mechan studi show adsorpt toward rb sy domin chemic adsorpt five adsorpt desorpt cycl found initi adsorpt capac could retain studi demonstr great potenti scpp g composit gel adsorb water treatment | D048271;D014874 | T121;T109;T131 |
36,244,540 | gallic acid function chitosan immobil nanosilv modifi chitosanpoli vinyl alcohol composit film food spoilag caus bacteri growth serious threat human health silver nanoparticl agnp antibacteri activ various pathogen microorgan rapid releas often lead cumul toxic paper silver nanoparticl agnp cg reduc immobil situ use gallic acid function chitosan cg reduc stabil agent achiev long last stabl control releas ag agnp cg incorpor cgpva composit film result show releas ag mgl seven day long last antibacteri effect e coli aureus addit cgpvaagnp composit film signific improv fresh preserv effect fresh cut appl preserv applic conclus cgpvaagnp composit film potenti applic effect safe packag materi extend shelf life food product | D048271;D053768 | T121;T109;T073 |
36,244,539 | rheolog insight polysaccharideprotein base hydrogel recent food biomed field review except network assembl natur polysaccharidesprotein base hydrogel offer favor biolog characterist tunabl physic properti make ideal candid food biomed applic rheolog analysi provid quantit inform insight assembl network critic determin hydrogel properti suitabl food biomed use review introduc concept rheolog brought togeth hydrogel base ten natur biopolym starch pectin gellan xanthan algin gelatin carrageenan soy protein casein protein whey protein agar cellulos konjac glucomannan relat rheolog studi addit combin previous work effect divers cross link strategi rheolog role various rheolog characterist modulus variat shear behavior chang thixotropi creep recoveri capabl etc gel design applic print base food activ ingredi carrier etc also discuss | D020100;D000464 | T121;T109;T122 |
36,244,538 | chitosan base therapeut system potenti treatment oral diseas increas morbid oral diseas dental cari periodont oral cancer great compromis life qualiti human rapid develop biomateri nanotechnolog various biomateri base system report treat oral diseas biocompat biodegrad bioadhes polysaccharid biomateri chitosan deriv also wide use oral diseas therapi either antibacteri agent drug deliveri carrier tissu engin scaffold well demonstr chitosan signific enhanc therapi efficaci various oral diseas due intrins antibacteri activ control drug releas featur herein aim provid comprehens understand biolog function chitosan antimicrobi anticanc reminer activ summar applic chitosan base therapeut system treat typic oral diseas includ dental cari endodont diseas periodont diseas oral cancer oral maxillofaci surgeri oral mucos diseas addit concern possibl solut clinic use chitosan also discuss | D048271;D003731 | T121;T047;T109;T033 |
36,244,537 | tough antibacteri fish scale gelatinchitosan film excel water vapor uv block perform compris liquefi chitin silica sol develop biodegrad non toxic materi replac petrochem polym import herein wast fish scale deriv gelatin chosen prepar environment friend film natur product fish scale gelatin fsg film weak low humid stabil poor antibacteri activ poor mechan strength weak uv absorpt henc novel multifunct mechan robust fsg base composit propos use chitosan cts crosslink matrix liquefi chitin product lcp silica sol function filler thermal decomposit kinet pyrolysi analysi show function fill compon compat fsgcts base macromolecul matrix incorpor lcp signific improv film flexibl antibacteri capac uv absorpt addit silica sol also increas mechan strength water toler decreas water vapor permeabl wvp increas appar activ energi ea along pyrolysi reaction could correl well composit film progress crosslink studi demonstr renew fsgctslcpsi composit film much improv properti could potenti applic film base packag | D005780;D048271 | T121;T109;T116 |
36,244,536 | sporopollenin invinc biopolym sustain biomed applic object review articl present util sporopollenin natur biopolym wide rang applic sporopollenin ubiquit natur polym chief ingredi plant pollen grain spore chemic inert sporopollenin beauti sculpt decor nano porous surfac speci uniqu organ aqueous solut stabl purifi sporopollenin keep spore pollen particl shape size surfac properti remain empti shell sporopollenin microcapsul sporopollenin microcapsul sporopollenin exin shell sec pollen grain plant angiosperm spore bryophyt pteridophyt gymnosperm fungi develop new biomateri drugvaccin deliveri catalyst support heavi metal remov among sustain applic review paper could pave way research sporopollenin product develop novel biomimet polym desir inert characterist author anticip uniqu renew polym abund natur made varieti plant fungal sourc biomed applic contribut sustain futur | D002338;D011058 | T121;T109;T123;T002 |
36,244,535 | anti prolif action molecular investig comput studi novel fuse heterocycl cellulos compound human cancer cell reactiv mcec diazonium chlorid dmf dma nh nh afford fuse heterocycl cellulos deriv confirm spectral analysi also cellulos compound evalu growth inhibitori activ contra cancer cell caco use neutral red uptak assay compound mcen mcpt mcpt b show better growth inhibitori activ caco growth compar control valu compound mcpi exert best cytotox activ cell h express level hif catenin myc cyclin mmp gene cell examin use qrt pcr compound mcen mcpi regul level catenin myc cyclin mmp gene regul level hif treat cell compar control valu also biolog studi confirm dock stimul differ protein show least bind energi amino acid attach nh oh cellulos hydrogen bond interact moreov optim compound use dft g show stabil identifi physic descriptor show excel correl experiment result noteworthi compound mcen mcpi promis anticanc agent lung cancer regul apoptosi cell cycl prolifer progress chemo resist angiogenesi | D000970;D009369 | T121;T109;T191 |
36,244,534 | hf zeolit high effici catalyst product hydroxymethylfurfur cellulos biphas system work seri x hf zeolit catalyst prepar simpl wet impregn method use bifunct catalyst lewi brnsted acid site synthes hydroxymethylfurfur hmf cellulos h nacl thf biphas system character analysi x hf zeolit catalyst icp oe n adsorpt desorpt isotherm xrd ftir sem nh tpd py ftir indic catalyst possess favor pore structur appropri acid strength acid superior cellulos convers hmf yield could obtain c h use hf zeolit catalyst addit catalyt system provid favor hmf yield carbohydr includ glucos sucros starch maltos dextran moso bamboo nevertheless recycl hf zeolit catalyst unsatisfactori hmf yield show downtrend cycl catalyst promis potenti convert biomass materi high valu platform compound | D002482;D017641 | T109;T123;T122;T197 |
36,244,532 | synergist antibacteri activ chitosan modifi doubl antibacteri agent coat materi fruit preserv chitosan cs natur marin polysaccharid good biocompat biodegrad poor water solubl antibacteri activ limit applic fruit preserv studi base advantag quaternari phosphonium salt qp salicyl acid sa good antibacteri activ differ antibacteri mechan novel antibacteri coat materi synthes graft qp sa onto cs graft sa qp onto cs crystallin cs molecul decreas water solubl improv also antibacteri activ cs qp sa escherichia coli staphylococcus aureus colletotrichum gloeosporioid anthracnos improv synergist effect qp sa day storag mango fruit treat cs qp sa weight loss rate fruit decay incid henc cs qp sa film effect extend storag time mango fruit certain extent result studi indic cs qp sa might promis preserv fruit veget | D048271;D031022 | T121;T109;T168;T002 |
36,244,531 | prepar applic composit phase chang materi stabil cellulos nanofibril base foam thermal energi storag leakag issu inferior heat conduct organ phase chang materi pcms limit actual applic present studi cellulos nanofibril cnf base foam prepar porous scaffold polyethylen glycol peg paraffin wax pw prevent leakag multiwal carbon nanotub cnts incorpor improv heat transfer perform prepar foam low densiti select chemic modif nanocellulos foam enhanc shape stabil compat pcms high porous foam structur favor compat result high pcm load level peg pw neglig pcm leakag cnts improv heat transfer perform pcms evidenc improv thermal conduct boost temperatur rise solar heat meanwhil composit pcms exhibit improv thermal stabil control peg base composit pcm exhibit phase chang enthalpi kjkg melt temperatur c pw base composit pcm exhibit phase chang enthalpi kjkg melt temperatur c novel pcm sandwich structur base composit pcms thermoelectr generat design display promis potenti solar energi harvest util | D006358;D037742 | T104;T073;T070 |
36,244,524 | weight head acceler mechan wham visual brain rheolog use magnet reson imag devic move head mr imag call weight head acceler mechan wham rotat head supin subject within programm rotat limit acceler profil wham use custom mri sequenc visual deform recoil vivo brain parenchyma high tempor resolut allow element wise calcul strain shear forc brain unlik previous devic wham configur provid wide rang motion acceler profil | D008279;D001921 | T059;T023;T060;T170 |
36,244,523 | elucid role mabamb starch degrad banana typic starch convers fruit high content starch harvest quick digest convert solubl sugar postharvest ripen process ultim contribut fruit flavor process regul complex manner gene environment factor mabamb one main enzym gene previous found transcriptom analysi high express banana fruit howev exact role starch degrad remain unclear full length mabamb isol banana fruit subcellular local protein express transient express banana fruit slice investig addit sens anti sens mabamb transform rice oryza sativa l japonica cv nipponbar identifi function mabamb mabamb bp encod amino acid contain two conserv domain pln glycosyl hydrolas famili local chloroplast protein express pattern mabamb remain consist high throughout banana fruit ripen starch degrad transient overexpress inhibit mabamb banana fruit great improv suppress starch degrad genet modif rice indic overexpress mabamb great improv starch degrad seed germin inhibit express suppress biolog process result support key role mabamb starch degrad provid target gene banana fruit qualiti improv biolog breed | D018506;D028521 | T045;T168;T002 |
36,244,518 | crocin main activ saffron crocus sativus l constitu potenti candid prevent anxieti depress like behavior induc unpredict chronic mild stress saffron dri stigma crocus sativus l famous high valu agricultur product iran exclus use cook purpos well known treat mood cognit disord antioxid anti inflammatori activ howev major medicin properti saffron associ main compon name crocin sever evid base studi confirm strong posit correl stress hormon depress main aim present studi determin potenti antidepress effect crocin saffron constitut unpredict chronic mild stress ucm induc anxieti depress rat | D027622 | T002 |
36,244,510 | rapid back flush direct sampl inject bio analyt hplc uv method therapeut drug monitor terbinafin rapid back flush bf direct sampl inject dsi high perform liquid chromatographi hplc uv detect bf dsi hplc uv develop determin terbinafin terb human serum onlin solid phase extract step isocrat mobil phase phosphat buffer salin ph mlmin short protein coat od column pc od column use purif enrich terb two differ chromatograph mode pc od column simultan oper macromolecular protein extract size exclus liquid chromatographi terb trap enrich achiev revers phase liquid chromatographi clear fraction contain terb transfer pc od column bf mode onto quantif step high pressur switch valv analyt mobil phase consist methanol triethylamin distil deioniz water ph mlmin use final separ od analyt column terb quantifi detect uv detector nm propos method show high correl coeffici concentr rang ngml recoveri rang measur terb concentr serum administr singl dose mg oral tablet use evalu applic bf dsi hplc uv pharmacokinet studi | D016903;D052616 | T059;T061;T058 |
36,244,505 | central autonom system revisit converg evid regulatori role insular midcingul cortex neuroimag meta analys autonom nervous system regul dynam bodi adapt intern extern environ chang capit two differ algorithm differ empir assumpt scrutin meta analyt converg human neuroimag studi investig neural basi peripher autonom signal process among select studi identifi record report differ experi test healthi individu result two differ algorithm converg identifi bilater dorsal anterior insula midcingul cortex critic area central autonom system appli unbias approach abl identifi singl condit independ function circuit support activ partial overlap salienc network function circuit includ bilater insular cortex midcingul cortex well bilater inferior pariet lobul remark critic region observ meta analysi overlap salienc network well region common report across differ cognit affect neuroimag paradigm region dysregul across differ mental neurolog disord | D001931;D001921 | T023;T062;T060 |
36,244,504 | laminin mutant studi reveal hierarchi within laminin gene requir basal epitheli tissu fold process morphogenesi care craft cell complex organ structur allow perform uniqu function brain develop neuroepitheli tissu must go apic basal fold mediat instruct intrins extrins factor much known apic fold mechan regul basal fold less understood use high conserv zebrafish midbrain hindbrain boundari mhb epitheli tissu model identifi basement membran protein laminin key extrins factor basal tissu fold laminin high conserv heterotrimer protein line basal surfac neuroepithelium laminin compris one alpha one beta one gamma chain encod gene lama lamb lamc respect human mutat individu laminin gene result dispar diseas phenotyp therefor hypothes laminin gene would distinct role tissu morphogenesi use zebrafish mutant laminin gene found laminin chain uniqu impact basal fold found lamc critic gene mhb morphogenesi follow lama final lamba hierarchi discov via three dimension singl cell shape analysi local myosin regulatori light chain mrlc analysi mhb tissu fold later develop find essenti develop novel techniqu tissu engin elucid differ human diseas due specif chain mutat | D015027;D007797 | T123;T116;T013 |
36,244,503 | paxa spa spl act downstream fgf wnt coordin sensori neural pattern inner ear zebrafish sensori epithelia neuroblast inner ear form simultan abut medial later domain respect floor otic vesicl previous studi support regulatori role fgf wnt signal coordin poor understood investig problem use pharmacolog transgen method alter fgf wnt signal earli placod stage evalu later chang growth pattern block fgf stage reduc prolifer otic tissu termin sensori neural specif wnt promot prolifer otic vesicl requir sensori neural develop howev sustain overactiv wnt later expand sensori epithelia block neurogenesi paxa spa spl coregul fgf wnt show overlap express otic placod vesicl gain loss function studi show gene togeth requir wnt suppress neurogenesi well aspect sensori develop thus paxa spa spl critic mediat fgf wnt signal promot spatial local sensori neural develop | D015027;D007758 | T023;T013 |
36,244,502 | subtl ecosystem effect microplast exposur marin mesocosm includ fish two month communiti outdoor marin mesocosm expos sphere shape polystyren ps bead dosag gm barnacl semibalanus balanoid densiti reduc dosag gm onward without follow standard dose respons curv lugworm fish solea solea ingest ps bead without accumul lugworm arenicola marina ingest bead nonselect sediment without negat effect fish seem ingest plastic occasion final sampl day even highest dose mesocosm beadscm contain plastic condit index fish slight reduc mesocosm dosag gm onward differ condit found fish without ingest plastic across mesocosm illustr difficulti relat plastic ingest condit field data fish also ingest mollusk shell exceed size ps bead bivalv reject ps bead pseudofec without obvious impact condit mussel mytilus eduli pseudofec present effect matrix monitor microplast presenc water column speci rich divers pelag benthic communiti affect although trend found lower microplast dosag posit effect total abund benthic invertebr general observ effect even highest exposur concentr subtl obscur natur variat field underlin import experi semi field condit meaning assess ecolog impact microplast studi perform real life non toxic sphere shape polystyren bead lost actual spill near dutch wadden sea januari recommend futur mesocosm studi type microplast includ microfib weather microplast sea smaller size particl nanoplast | D014874;D049880;D005412 | T131;T013;T204 |
36,244,501 | gradient suspend particul matter hasten multi interfac partit dynam atrazin degrad product herbicid ubiquit pollut estuari increas demand food need intens agricultur system worldwid multi interfac partit process inadequ degrad product herbicid especi sediment laden river estuari intens water sediment partit therefor partit characterist atrazin degrad product surfac water suspend particul matter spm surfac water surfac sediment spm surfac sediment interfac typic sediment laden river estuari analyz domin environment factor describ relat mechan explor result show partit prioriti atrazin degrad product surfac water spm surfac sediment partit coeffici three interfac signific correl primari degrad product desisopropylhydroxyatrazin tend partit spm desethyldesisopropylatrazin tend partit surfac sediment canon analysi structur equat model indic temperatur salin sediment ph spm concentr main influenc factor sediment laden river estuari spm concentr domin factor partit coeffici increas exponenti spm concentr mgl spm surfac sediment interfac lead rapid shift interfac proport atrazin degrad product context climat chang human activ spm concentr estuari decreas hasten releas potenti atrazin degrad product estuarin sediment investig partit trait organ degrad pollut promot understand multi interfac transport process estuari | D001280;D014874;D006540 | T121;T109;T131 |
36,244,499 | effect anthropogen precursor emiss meteorolog condit pm concentr citi northern china elucid characterist influenc mechan pm concentr premis key precis prevent control air pollut howev tempor spatial heterogen pm concentr drive mechan complex need analyz analyz tempor spatial variat pm concentr citi quantifi influenc meteorolog factor anthropogen emiss interact pm concentr base geograph detector model find inter annual inter season pm concentr show downward trend inter month pm concentr present u shape distribut pm concentr citi manifest spatial distribut pattern high south low north high middl low surround meteorolog condit stronger effect pm concentr anthropogen emiss planetari boundari layer height temperatur two main drive factor annual scale season scale sunshin durat domin factor pm concentr summer autumn planetari boundari layer height domin factor pm concentr winter effect anthropogen emiss pm concentr higher winter spring summer autumn ammonia ozon stronger effect pm concentr anthropogen emiss interact factor signific enhanc pm concentr interact planetari boundari layer height impact factor play domin role pm concentr annual scale winter result provid crucial inform develop air qualiti polici citi also bear sever import implic clean air polici china region world | D000393;D000397 | T069;T131;T080 |
36,244,498 | impair graze marin protozoa sub lethal exposur water accommod fraction crude oil dispers despit advanc safeti technolog improv implement precautionari measur crude oil pollut occur ocean global water accommod fraction waf crude oil chemic dispers hypothes caus sub lethal advers effect marin protist pivot consum primari product exposur experi conduct investig effect crude oil dispers pollut growth graze separ protozoa speci cultur exposur l l chemic enhanc waf cewaf heterotroph dinoflagel protoperidinium sp ciliat metacyli sp show slower posit popul growth negat popul growth even low concentr dose respons model show protoperidinium sp metacyli sp high suscept cewaf toxic median inhibit concentr ic l l respect one algal speci ditylum brightwellii relat toler toxic ic l l suppress growth impair graze protozoan speci high cewaf concentr accumul algal prey cultur contain observ reflect higher final initi prey ratio high cewaf concentr addit exposur experi treatment waf dispers alon disp cewaf concentr reveal heterotroph dinoflagel oxyrrhi marina reduc bulk graze impact toward algal prey popul three treatment compar control treatment ie graze mortal prey similar protoperidinium sp metacyli sp reduc per capita prey ingest rate exposur waf cewaf compar control treatment studi provid experiment evid potenti link impair graze activ format algal bloom sub lethal exposur crude oil pollut | D010578;D014874;D059392;D017377 | T069;T109;T131;T204 |
36,244,497 | new insight glass industri wasteland ecosystem glass manufactur oper lead increas number abandon slag heap contamin metal trace element mte howev relat influenc edaph factor biodivers glasswork wasteland still poor understood although close relat sustain land manag practic therefor object research provid new insight glasswork wasteland investig orthoptera diurnal lepidoptera plant communiti ii abiot paramet topsoil end biodivers indic comput ecolog inventori perform herbac layer addit soil sampl taken topsoil layer cm assess agronom properti actual cec exchang potenti bioavail mte fraction dtpa extract pseudo total mte content one hand studi site abl support substanti higher except biodivers orthopteran assemblag similar grassland diurnal lepidoptera divers compar urban park also note posit influenc plant rich diurnal lepidoptera communiti structur hand topsoil analysi reveal sever pb contamin mg kg high potenti bioavail pb fraction mg kg howev cec exchang mte concentr analyt quantif limit moreov site character medium soil fertil result pb contamin appear primari limit factor establish communiti assum glasswork wasteland ecosytem affect soil fertil land manag practic conclud site abl provid biodivers ecosystem servic act wildlif sanctuari orthoptera diurnal lepidoptera strateg metal phytoextract circular economi model thus wasteland manag practic consid local scale driver biodivers order reach least zero net loss biodivers | D012989;D014131 | T121;T131;T123;T196 |
36,244,496 | effect exposur environment relev pfas concentr aquat organ differ consum trophic level systemat review meta analys per polyfluoroalkyl substanc pfas collect name approxim synthet chemic ubiquit aquat environ worldwid use wide array product found live organ around world pfas associ cancer development toxic endocrin disrupt health effect fraction pfas current monitor regul presenc effect aquat organ mani pfas larg unknown aim studi investig health effect environment relev concentr pfas aquat organ differ consum trophic level systemat review meta analysi main result show pfas concentr gl advers effect bodi size variabl secondari consum howev signific effect liver gonad somat indic neither fecund found addit result show larg research gap pfas effect differ organ aquat environ environment relev concentr studi perform secondari consum substanti lack studi consum aquat ecosystem | D005466 | T109 |
36,244,495 | efficaci metal nanoparticl attenu accumul toxic chromium plant current knowledg futur perspect nanoparticl emerg cut edg technolog improv crop yield safe cultiv agricultur plant especi peripher area impair toxic heavi metal includ chromium cr uncontrol releas cr main anthropogen factor substanti pollut surround environ therebi extens accumul soil plant system excess cr accret plant tissu disturb morph physiolog biochem cellular metabol molecular process impair plant function therefor obligatori restrict accumul toxic effect cr plant organ recent studi metal nanoparticl mnps iron oxid silicon dioxid copper oxid zinc oxid approv efficaci potent pool curb cr induc phytotox improv plant toler mnps attenu bioaccumul phytotox cr util key mechan improv photosynthet machineri regul cellular metabolit greater chelat capac bind cr releas correspond metal ion upsurg uptak essenti nutrient activ antioxid enzymat non enzymat reduct oxid stress cellular injuri thus improv plant growth perform briefli discuss current knowledg research gap exist literatur along possibl recommend futur research overal cr detoxif mnps may depend upon target plant speci cr speciat plant growth stage seedl veget ripen etc treatment method foliar spray seed prime nutrient solut etc type size dose coat appli mnps condit hydropon soil environ etc review would help plant scientist develop mnps base strategi nano fertil allevi cr accumul toxic impact may lead safe healthi food product review outcom provid new horizon research applic mnps sustain agricultur | D012989;D053768 | T131;T073 |
36,244,425 | denitrif nitrat regener wast brine use hybrid cation exchang support nanoscal zero valent iron withwithout palladium nanoparticl sustain develop goal requir reduc wast prioriti work describ applic innov zero wast hybrid ion exchang nanotechnolog concurr remov nitrat induc denitrif ammonia abil generat fertil agricultur sector recycl product herein hybrid cation exchang support zero valent iron fe bimetal fe pd nanoparticl hcix fe hcix fe pd synthes success valid denitrif nitrat spent wast brine contain nitrat kinet nitrat catalysi hcix fe hcix fe pd compar present six kinet model name zero order pseudo first second order reaction pseudo first second order adsorpt elovich hcix fe pd display higher kinet valu hcix fe k min respect nitrat predomin catalys nh ratio ammonia nitrogen compound around although hcix fe pd show slight better kinet result determin unfavour real life applic due low select toward n gas need use h gas base practic hcix fe valid effect salt use nacl role initi ph condit optim discuss recoveri nitrat remov also calcul recoveri rang obtain three consecut run sustain novel zero wast hybrid ion exchang nanotechnolog use combin two fix bed column contain nitrat select resin nitrat remov novel hcix fe nitrat reduct nh may promis sustain solut toward goal discharg zero nitrat wast environ | D053768;D014874 | T131;T073 |
36,244,424 | effect synthet progestin levonorgestrel aspect thyroid physiolog common carp cyprinus carpio object present studi assess effect levonorgestrel lng synthet progestin earli develop thyroid system carp use morpholog histolog immunohistochem gene express analysi fish expos lng three level ng l egg onset juvenil stage day lng signific effect earli develop common carp occurr morpholog anomali patholog alter thyroid follicl found immunohistochem examin thyroid follicl use antibodi thyroxin show differ fish expos ng l lng compar control mrna express iodothyronin deiodinas dio differenti affect lng treatment carp develop import dio mark downregul fish expos three lng level compar control conclus experi day post fertil decreas dio dio increas dio transcript observ differ time point studi may sign hypothyroid mrna express gene npr esr esrb bodi npr esrb head fish expos ng l lng signific upregul compar solvent control group end test togeth result show levonorgestrel caus parallel chang hypothalamus pituitari thyroid hypothalamus pituitari gonad axe | D016912;D002347 | T121;T109;T013;T125 |
36,244,423 | effici applic newli synthes green bi nanoparticl sustain biodiesel product via membran reactor introduct wast non edibl oil seed coupl green nanotechnolog offer pushov sustain econom biofuel bio refineri product global current studi encompass synthesi applic novel green high reactiv recycl bismuth oxid nanocatalyst deriv euphorbia royealeana falc boiss leav extract via biolog method sustain biofuel synthesi high potent cannabi sativa seed oil ww via membran reactor advanc techniqu x ray diffract xrd scan electron microscopi sem energi diffract x ray edx ft ir employ illustr newli synthes green bismuth oxid nanoparticl fame produc optim reaction condit ww catalyst weight oil methanol molar ratio reaction temperatur c h via membran reactor synthes cannabi biodiesel identifi use ft ir gc ms techniqu fuel properti synthes biofuel acid number mg kohg densiti kgl kinemat viscos cst flash point c pour point c cloud point c sulfur wt carbon residu studi establish compar intern set paramet experiment data r show reaction follow pseudo first order kinet find affirm applic green bismuth oxid nanoparticl econom high reactiv eco friend candid industri scale biodiesel product non edibl oil seed | D056804;D053758 | T109;T073 |
36,244,422 | evalu releas metabol ricinin castor cake fertil soil use lc qtofm coupl sirius workflow castor cake major product generat castor oil extract wide use organ fertil appli soil toxic alkaloid ricinin castor cake may releas soil subsequ taken crop pose potenti threat food safeti human health howev environment fate castor cake deriv ricinin agroecosystem remain unclear studi releas metabol ricinin soil conduct use soil pot experi differ castor cake applic rate analyt methodolog ricinin quantif soil pore water first establish use solid phase extract spe coupl liquid chromatographi quadrupol time flight mass spectrometri lc qtofm non target screen workflow associ lc qtofm sirius platform develop identifi ricinin metabolit soil pore water castor cake applic ricinin concentr soil pore water signific increas g l day gradual decreas g l day g l day select two test soil castor cake applic rate g castor cakekg soil addit two ricinin metabolit r r tentat identifi one ricinin metabolit n demethyl ricinin confirm authent refer standard first time develop non target screen workflow studi highlight releas metabol toxic alkaloid ricinin soil appli castor cake organ fertil ricinin could releas soil pore water short term castor cake applic undergo demethyl hydroxyl hydroxyl follow methyl metabol time agroecosystem | D005308;D000470 | T073;T131;T121;T109;T123 |
36,244,421 | concav gold nano arrow aucna effici catalyt reduct nitrophenol anisotrop gold nanostructur attract great attent differ field includ catalysi thermodynam driven select surfac growth offer reliabl reproduc method anisotrop gold nanoparticl synthesi specif morpholog herein monocrystallin concav gold nano arrow aucna prepar growth method use au nanorod aunr seed prepar aucna consist bicon head four concav structur interest silver ion ag concentr signific affect product morpholog tune peak posit surfac plasmon reson spr aspect ratio arrow concav morpholog aucna posit longitudin spr peak observ nm ag au molar ratio respect diamet length aucna vari nm nm nm nm nm respect addit aucna appli catalyt reduct nitrophenol np aminophenol ap presenc excess nabh compar gold nanorod aunr prepar aucna catalyst show excel catalyt activ demonstr concav structur sharp corner signific enhanc catalyt activ valu pseudo first order reaction kinet constant k app increas increas catalyst valum l highest normal reaction rate constant k turnov frequenc tof reach min mmol h respect ag au ratio aucna catalyst studi expand catalyt applic anisotrop gold nanostructur widen potenti applic area surfac plasmon exciton photon biomed photon photocatalysi | D006046;D053768 | T121;T196;T073 |
36,244,420 | ambient air pollut bone miner densiti osteoporosi result nation popul base cohort studi evid concern associ ambient air pollut exposur bone miner densiti osteoporosi mix conduct cross section prospect analysi associ air pollut exposur osteoporosi use data uk biobank studi estim bone miner densiti ebmd particip baselin survey calcul use quantit ultrasound data incid osteoporosi case identifi follow period accord health relat record air pollut concentr assess use land use regress model fit multivari linear logist regress model estim associ air pollut ebmd osteoporosi preval baselin appli cox proport hazard regress model assess relationship air pollut osteoporosi incid among particip baselin higher air pollut exposur associ lower ebmd level increas odd osteoporosi preval exampl iqr increas pm pm absorb pm x level associ ci ci gcm decreas ebmd total particip without osteoporosi follow averag year identifi incid osteoporosi case case patholog fractur case without patholog fractur follow hazard ratio interquartil rang increas pm pm absorb pm x ci ci ci ci ci respect studi suggest ambient air pollut might risk factor decreas bone miner densiti osteoporosi incid | D000393;D005598;D000397;D010024 | T047;T046;T131;T069;T080 |
36,244,419 | high effici situ cleaner degrad difenoconazol two novel domin strain microflora divers monoclon isol growth factor optim intermedi pathway non point sourc pollut difenoconazol dif becom serious environment issu increas caus indel damag eco environ human health due toxic persist biomagnif eco friend cost effect effici control technolog imper toward cleaner sustain agricultur product herein domin microflora effici degrad dif success screen microbi divers investig two novel degrad strain isol identifi phyllobacterium sp aeromona sp result growth factor optim indic degrad rate dif c mgl strain within respect optim condit moreov obvious synergi strain strain catalyt kinet enzym intracellular enzym strain domin degrad dif c mgl entir degrad rate h extracellular enzym show littl catalyt activ howev degrad rate dif c mgl intracellular extracellular enzym strain within h respect moreov enzym remain undiminish catalyt activ within h dif degrad strain three main transform product dif tps dif tps dif tps undergo hydroxyl substitut hydrolysi cleavag ether bond benzen ring rearrang two addit product dif tps dif tps generat biodegrad strain except dif tps dif tps involv hydrolysi hydroxyl ether bond cleavag benzen ring moreov qsar simul show product almost much lower toxic even non toxic three typic aquat organ fish daphnia green alga dif studi provid depth understand dif bioelimin also instrument cleaner manag dif contamin soil studi promot sustain develop agricultur | D001554;D036341 | T109;T131;T116;T123 |
36,244,418 | sorption desorpt bisphenol commerci plastic effect uv age plastic gradual degrad natur environ effect irradi chang surfac properti plastic affect migrat behaviour pollut studi sorptiondesorpt behaviour organ pollut age plastic still limit studi sever type commerci plastic polyurethan pu polyamid pa polyvinyl chlorid pvc expand polystyren ep select investig sorption releas behaviour four kind bisphenol bisphenol f b ap result raman spectroscopi scan electron microscopi sem analysi show evid oxid surfac crack plastic irradi sorption behaviour fresh age plastic domin hydrophob addit electrostat forc h bond interact interact also import factor impact sorption process desorpt kinet behaviour indic desorpt becom faster age hydrophob also import factor affect desorpt behaviour studi show sorption capac fresh age plastic enhanc impact salin dissolv organ matter dom increas temperatur could increas desorpt bisphenol fresh age plastic illustr warm environ would promot pollut releas plastic water bodi | D014874;D004785 | T131 |
36,244,417 | effect degrad chloramphenicol wastewat activ peroxymonosulf fe rich porous biochar deriv petrochem sludg excess sludg produc biolog wastewat treatment plant petroleum industri kind hazard solid wast convert sludg biochar catalyst may help reduc environment risk recov resourc increas econom effici howev role sludg biochar persulf activ remain unclear limit applic remov organ pollut water bodi studi metal rich petrochem sludg use produc activ sludg biochar asc via two step method pyrolyt carbon c c subsequ koh activ abbrevi asc physio chemic properti asc character fourier transform infrar spectroscopi ftir x ray diffract xrd scan electron microscopi sem brunauer emmett teller bet raman chloramphenicol cap remov perform asc peroxymonosulf pms system evalu result show porous sludg biochar success prepar two step method c specif surfac area asc reach highest valu g c fe fe graphit carbon form asc among asc asc exhibit best cap remov perform asc pms system adsorpt combin catalyt degrad optim condit identifi mm cap remov asc g l pms mm ph oh may contribut cap degrad degrad pathway cap propos base identifi degrad intermedi overal studi confirm porous biochar deriv petrochem sludg effect adsorb pms catalyst remov organ pollut wastewat | D004785;D014874 | T131 |
36,244,416 | plasma concentr perfluoroalkyl acid determin youth adult nunavik canada perfluoroalkyl acid pfaa subset per poli fluoroalkyl substanc pfas environment stabl mobil bioaccumul compound lead high concentr wildlif speci essenti cultur ident subsist arctic popul object character distribut exposur determin pfaa among nunavik inuit adult studi includ nunavik resid age year particip qanuilirpitaa nunavik inuit health survey q plasma concentr compar general canadian popul use data canadian health measur survey cycl associ plasma concentr nine pfaa determin liquid chromatographi tandem mass spectrometri sociodemograph factor tradit activ particip examin use multipl linear regress model overal exposur pfaa twice high compar general canadian popul less regul perfluorononano acid pfna perfluoroundecano acid pfunda concentr fold higher perfluorodecano acid pfda concentr fold higher male higher concentr perfluorooctano acid pfoa perfluorohexan sulfon pfhxs wherea femal higher concentr pfda pfunda pfaa concentr increas age highest among age year pfna pfoa concentr follow j shape pattern age year higher concentr age year ungava bay general lower concentr pfaa congen compar hudson bay hudson strait except pfna tend lowest concentr hudson strait pfaa concentr high associ hunt activ omega polyunsatur fatti acid drink water environment sourc result highlight import character pfaa exposur sourc arctic communiti provid evid long rang transport long chain pfaa precursor necessit intern action | D005466;D017738;D004785 | T109;T131 |
36,244,413 | cognit behavior effect anti epilept drug cenobam ykp under synapt cellular mechan antiseizur medic mainstay treatment seizur adjunct therapi wide use achiev adequ seizur control patient epilepsi fail respond first monotherapi newli develop antiepilept drug cenobam ykp adjunct therapi improv seizur control patient uncontrol focal seizur cenobam thought reduc neuron excit action multipl target includ gaba receptor gaba rs voltag gate sodium channel howev effect brain function synapt plastic unclear explor behavior synapt cellular action cenobam cenobam influenc novel object recognit object locat memori morri water maze perform mice cenobam enhanc inhibitori postsynapt potenti prolong inhibitori postsynapt current ipsc decay without affect presynapt gaba releas peak amplitud ipsc addit cenobam suppress hippocamp excitatori synapt transmiss reduc excit schaffer collater interf induct long term potenti reduct neuron excit induc cenobam associ elev action potenti ap threshold progress increas later ap repetit fire indic activ depend modul neuron sodium current cenobam suppress neuron excit condit gabaerg neurotransmiss excitatori administr cenobam rapid enhanc phosphoryl eukaryot elong factor hippocampus adult neonat mice collect result suggest combin action cenobam sodium current gaba r mediat synaps respons result reduc excit neuron | D012640;D009435 | T043;T047;T046;T184 |
36,244,398 | bemarituzumab patient fgfrb select gastric gastro oesophag junction adenocarcinoma fight randomis doubl blind placebo control phase studi outcom poor patient negat advanc gastric gastro oesophag junction adenocarcinoma studi investig efficaci safeti first class afucosyl humanis igg anti fibroblast growth factor receptor isoform iib fgfrb monoclon antibodi bemarituzumab modifi fluorouracil leucovorin oxaliplatin mfolfox patient fgfrb select gastric gastro oesophag junction adenocarcinoma | D013274;D000230 | T191 |
36,244,384 | aqueous skin antisepsi surgic fixat open fractur aqueous prep multipl period cluster randomis crossov trial chlorhexidin skin antisepsi frequent recommend surgic procedur howev unclear recommend appli surgeri involv traumat contamin wound povidon iodin previous prefer aim compar effect aqueous povidon iodin versus aqueous chlorhexidin glucon risk surgic site infect patient requir surgeri open fractur | D000891;D005597 | T121;T037 |
36,244,383 | compar dedic design approach integr task share psycholog intervent chronic diseas care south africa three arm cluster randomis multicentr open label trial communiti health worker chws increas provid task share psycholog intervent depress alcohol use primari health care low incom middl incom countri aim compar effect chws dedic deliv care chws design deliv care exist respons treatment usual patient chronic physic diseas | D000437;D003924;D015658 | T047;T048 |
36,244,382 | sever covid outcom full vaccin primari schedul initi booster pool analysi nation prospect cohort studi million individu england northern ireland scotland wale current uk vaccin polici offer futur covid booster dose individu high risk serious ill covid still uncertain group popul could benefit respons urgent request uk joint committe vaccin immunis aim identifi risk factor sever covid outcom ie covid relat hospitalis death individu complet primari covid vaccin schedul receiv first booster vaccin | D000086382 | T047;T067 |
36,244,360 | mainten ketamin treatment depress systemat review efficaci safeti toler ketamin rapid yet often transient antidepress effect patient treatment resist depress differ strategi propos prolong effect mainten ketamin treatment appear promis littl known efficaci safeti toler depress search pubm embas cochran librari identifi three randomis control trial eight open label trial case seri report mainten ketamin treatment found intraven intranas oral possibl intramuscular subcutan mainten ketamin treatment effect sustain antidepress effect treatment resist depress tachyphylaxi cognit impair addict serious renal urinari problem seem uncommon despit methodolog limit conclud clinic view mainten ketamin treatment seem therapeut potenti recommend control naturalist studi long term follow suffici power determin posit mainten ketamin treatment within routin clinic practic | D061218;D007649 | T121;T109;T048 |
36,244,359 | psycholog distress depress anxieti life satisfact follow covid infect evid uk longitudin popul studi evid associ covid ill mental health mix aim examin whether covid associ deterior mental health consid pre pandem mental health time sinc infect subgroup differ confirm infect via self report test serolog data | D000086382;D000079225 | T047;T067;T048 |
36,244,350 | burden bacteri antimicrobi resist european region cross countri systemat analysi antimicrobi resist amr repres one crucial threat public health modern health care previous studi identifi challeng estim magnitud problem downstream effect human health mortal knowledg studi present comprehens set region countri level estim amr burden european region date | D000900;D055624 | T121;T007;T195 |
36,244,343 | boost sar cov bntb mrna vaccin elicit strong humor respons independ interv first two dose due recrudesc sever acut respiratori syndrom coronavirus sar cov infect worldwid main caus omicron variant concern voc sub lineag sever jurisdict administ mrna vaccin boost analyz humor respons induc second third dose mrna vaccin naiv previous infect donor receiv second dose extend week interv observ extend interv elicit robust humor respons voc respons signific diminish month second dose administ boost individu bring back humor respons level obtain extend second dose interest observ administ boost individu initi receiv short week regimen elicit humor respons similar observ long interv regimen nevertheless humor respons elicit boost naiv individu reach present previous infect vaccin individu | D000086382;D014765 | T121;T047;T067;T129 |
36,244,324 | design structur activ kinet studi benzyl oxa tetrahydro h chromeno c pyridin yl sulfam steroid sulfatas inhibitor steroid sulfatas inhibitor block local product estrogen steroid attract agent treatment estrogen depend cancer inspir coumarin base inhibitor synthes thirti two oxa tetrahydro h chromeno c pyridin yl sulfam focus substitut deriv adjac phenyl ring evalu abil block sts human placenta mcf cell sar analysi reveal incorpor chlorin either meta andor para posit adjac phenyl ring tricycl skeleton enhanc sts inhibit di substitut adjac phenyl ring superior mono tri substitut kinet analysi compound reveal chlorid bear compound v w k nm k inact k ratio nm min paramet indic effici irrevers inhibit also use dock model illustr differ sts inhibitori potenc compound final safeti anti cancer activ select compound v w also studi show result low cytotox nhdf cell line potent irosustat zr cell hormon depend cancer cell line high sts express | D043266;D004791 | T121;T126;T116 |
36,244,323 | sar studi novel truxil acid monoest base inhibitor fatti acid bind protein next generat antinocicept agent fatti acid bind protein fabp high promis target develop analges inhibit devoid cb r depend side effect design discoveri high potent fabp select truxil acid ta monoest tame primari aim present studi basi molecular dock analysi ca tame design screen silico funnel new tame synthes assay affin ki fabp sar studi reveal introduct h bond acceptor far end biphenyl yl biphenyl yl ester moieti improv affin tame fabp compound first tame demonstr high affin fabp compet tame identifi best tame base fabp select index clear front runner bear indanyl ester moieti sharp contrast tame made top list howev identifi potent fabp select inhibitor applic relat possibl use protect cardiac myocyt reduct synuclein accumul parkinson diseas among best tame select base affin fabp tame found fabp select select studi identifi sever tame fabp select inhibitor would potenti benefici therapeut effect diseas syndrom schizophrenia breast cancer astrocytoma success introduc ta monosilyl ester tams mediat protocol dramat improv overal yield tame tams tbdps silyl group isol good yield unreact ta meo ta well disilyl ester tads fulli recycl molecular dock analysi provid ration explan observ bind affin select fabp inhibitor includ isom studi | D050556;D000700 | T116;T131;T121;T109;T123 |
36,244,322 | design synthesi biolog evalu pyranocarbazol deriv alzheim diseas antioxid neuroprotect cognit enhanc properti seri novel pyranocarbazol alkaloid design synthes deriv claulansin f cz compound show strong neuroprotect effect anti lipid peroxid capac among compound b introduc leucin c posit pyranocarbazol activ inhibit program death sh syy cell compound exhibit stronger free radic scaveng activ edaravon furthermor b could penetr blood brain barrier bbb import b show tendenc improv learn memori dose rang mgkg research mechan indic b could reduc oxid stress brain intox mice improv cognit function intox mice find suggest b may promis evalu intervent alzheim diseas | D000544;D009447;D018696 | T047;T191;T121;T048;T169 |
36,244,321 | mesenchym stem cell deriv hif overexpress extracellular vesicl amelior hypoxia induc pancreat cell apoptosi senesc activ ythdf mediat protect autophagi pancreat islet transplant ideal treatment strategi type diabet mellitus tdm hypoxia induc pancreat cell death islet transplant huge obstacl caus failur therapi thus becom necessari improv pancreat cell viabil hypox condit present studi design mesenchym stem cell mscs deriv hypoxia induc factor hif overexpress extracellular vesicl ev hif ev found hif ev effect promot cell viabil autophagi suppress cell apoptosi senesc hypoxia treat pancreat cell addit blockag autophagi inhibitor methyladenin abrog rescu effect hif ev hypoxia induc pancreat cell death potenti under mechan hif ev trigger protect autophagi uncov found hif ev upregul ythdf result upregul autophagi associ protein atg atga atg abrog delet writer mettl final verifi hif ev rescu cell viabil revers hypoxia induc pancreat cell apoptosi senesc ythdf depend manner collect conclud mscs deriv hif ev activ ythdf mediat protect autophagi promot pancreat cell surviv hypox condit hif ev could use candid treatment strategi increas success rate islet transplant | D050417;D000067128;D059630 | T025;T026 |
36,244,320 | rethink margin stabil incorpor step step regul resolv paradox deriv invert pendulum dynam mediolater margin stabil mosml mechan ground measur instantan frontal plane stabil howev averag mosml measur yield paradox result gait patholog perturb often induc larger suppos stabl averag mosml despit clear destabil factor howev peopl walk averag walk sometim lose balanc one step time assert paradox aris averag mosml discard crucial step step dynam present framework unifi invert pendulum goal equival manifold gem analys identifi pendulum center mass dynam constant mosml manifold includ one candid stabil gem signifi goal maintain constant mosml use framework assess step step mosml dynam human walk destabil environ goal relev deviat readili correct peopl exploit equifin allow deviat persist along gem thus maintain constant mosml inconsist observ step step fluctuat center mass state convers extent particip regul fluctuat mediolater foot placement strong predict regul center mass fluctuat thus center mass dynam may aris indirect consequ regul mediolater foot placement help resolv paradox caus averag mosml present new statist probabl instabl poil use predict later instabl likelihood particip exhibit increas poil destabil p despit exhibit larger stabl averag mosml p thus poil correct captur peopl increas risk lose later balanc wherea averag mosml poil also help explain peopl averag mosml increas destabil context | D004856;D005684 | T040;T033 |
36,244,319 | cell extrins il signal control long term gammaherpesvirus infect suppress viral reactiv gammaherpesvirus establish life long infect adult associ sever cancer includ b cell lymphoma use murin gammaherpesvirus mhv anim model previous show pro viral role interleukin il signal support viral reactiv establish chronic infect unexpect studi found provir effect il signal origin observ establish chronic gammaherpesvirus infect convert antivir effect long term stage infect specif il signal promot expans antivir cd cell control viral reactiv periton caviti long term infect host use novel mous model cell specif il signal defici found antivir effect il signal cell extrins studi highlight dynam natur host factor shape paramet chronic gammaherpesvirus infect | D018142;D006566;D007375 | T116;T047;T005;T129 |
36,244,314 | synthesi character vitro cytotox ruthenium ii metronidazol complex cell cycl arrest gs transit apoptosi induct mcf cell ruthenium compound known potenti drug candid sinc offer potenti reduc toxic furthermor various oxid state differ mechan action ligand substitut kinet give advantag platinum base complex make suitabl use biolog applic herein novel ruthenium ii complex metronidazol ligand obtain rucl mtnz dppb mebipi pf rucl mtnz dppb methoxybipi pf rucl mtnz dppb bipi pf rucl mtnz dppb phen pf mtnz metronidazol dppb bis diphenylphosphino butan mebipi dimethyl bipyridin methoxybipi dimethoxi bipyridin bipi bipyridin phen phenanthrolin complex character element analysi molar conduct infrar uv vis spectroscopi cyclic voltammetri p h h c h dept nmr mass spectrometri interact complex dna evalu cytotox profil determin four differ tumor cell line deriv human cancer sk mel melanoma hepg hepatocarcinoma mcf estrogen posit breast cancer non small cell lung cancer demonstr complex promis antitumor agent inhibit prolif behavior mcf cell induc apoptosi | D012428;D002289;D056831;D008175;D000970 | T191;T121;T109;T196;T104 |
36,244,313 | current advanc develop manganes complex magnet reson imag probe emerg non invas molecular imag modal detect pathophysiolog state molecular level anatom chang observ magnet reson imag mri prefer nuclear imag techniqu owe radiat free approach convent mri contrast agent employ predomin involv lanthanid metal gadolinium gd discoveri associ sever nephrogen toxic issu limit led way develop manganes base contrast agent offer similar posit contrast enhanc capabl vast quantiti experiment data accumul last decad defin physicochem characterist manganes chelat various ligand scaffold one observ ligand configur rigid donor acceptor characterist impact stabil complex review cover current trend develop manganes base mri contrast agent mechan base design consider newer manganes base contrast agent higher diagnost strength along better safeti profil | D003287;D008345 | T123;T130;T196 |
36,244,312 | new multifunct ru ii organometal compound show activ trypanosoma brucei leishmania infantum human african trypanosomiasi sleep sick leishmaniasi preval zoonot diseas caus genom relat trypanosomatid protozoan parasit trypanosoma brucei leishmania spp addit co endem certain region world small number old drug exist treatment share poor safeti efficaci pharmacokinet profil work new multifunct ru ii ferrocenyl compound ration design potenti agent trypanosomatid parasit includ singl molecul bis diphenylphosphino ferrocen dppf two bioactiv bident ligand hydroxyquinolin deriv hqs polypyridyl ligand nn three ru hqs dppf nn pf compound synthes fulli character show vitro activ bloodstream trypanosoma brucei ic nm leishmania infantum promastigot ic compound show good select toward brucei respect j murin macrophag mammalian cell model si chang hexafluorophosph counterion chlorid led three fold increas activ parasit two three fold increas select toward pathogen compound affect vitro least target individu bioactiv moieti includ new chemic entiti dna generat ros compound stabl solut lipophil free bioactiv ligand clear correl lipophil interact dna generat ros activ detect agre overal similar anti trypanosoma potenc select compound promis candid drug develop | D014346;D018314;D014349;D009942 | T109;T204 |
36,244,311 | design synthesi novel palladium cyclometal base fluoresc probe studi interact cell membran confoc fluoresc lifetim imag coordin complex offer great potenti cellular imag probe allow examin specif cell organell structur physiolog condit better understand biolog system understand heterogen natur cell membran could unveil detail function develop new anthracen conjug fluoresc palladium ii cyclometal pdl cl l h anthracen ylmethylen phenylhydrazineyl pyridin h stand dissoci proton specif stain cell membran could util visualis membran confoc fluoresc lifetim imag microscopi flim probe unabl enter insid cell pass cell membran via diffus various organ metal transport howev great lipophil fluorescein improv interact probe peptidoglycan layer cell membran probabl dissoci chlorid ion format posit charg palladium complex result stain negat charg cell membran confoc imag clear express sole membran stain probe probe effici stain cancer cell hela mcf cell line normal cell hek confirm univers probe membran stain | D005456;D010165 | T196;T130 |
36,244,276 | advanc practic physiotherapist implement jigsaw e model manag osteoarthr scottish primari care set qualit case studi explor accept barrier enabl nice guidelin osteoarthr scottish primari care set use joint implement guidelin osteoarthr western europ jigsaw e model investig role advanc physiotherapi practition app provid evid base care | D059825;D058005;D010003 | T047;T097 |
36,244,275 | chang electromyograph activ latent trigger point dri needl intervent randomis control trial analys effect dri needl dn upper trapezius latent trigger point ltrps pressur pain threshold ppt surfac electromyographi semg | D000079245;D009209;D064171 | T061;T047;T184;T023 |
36,244,274 | aspect violenc lead distress chang attitud physiotherapist qualit investig physiotherapist often target workplac violenc investig physiotherapist make sens exposur experi aspect experi workplac violenc lead negat reaction chang attitud toward work organ | D059825 | T097 |
36,244,273 | measur effect airway clearanc mechan ventil infant children systemat review robust measur tool essenti guid physiotherapi deliv airway clearanc techniqu ventil infant children | D012121;D059825 | T061;T097 |
36,244,270 | optim swine vitro embryo product growth factor antioxid supplement oocyt matur porcin vitro fertil often result low embryo develop rate compar livestock speci often associ either low fertil rate high incid polyspermi sinc qualiti oocyt matur known play signific role oocyt compet investig impact supplement vitro matur ivm medium contain porcin follicular fluid pff growth factor fgf lif igf fli along differ combin cystein melatonin cumulus cell expans oocyt meiotic matur fertil outcom embryo develop blastocyst cell number matur medium contain pff yield greatest cumulus expans compar pff fli individu use pff fli togeth result best embryo develop rate total oocyt place ivf vs vs respect supplement ivm medium contain pff fli either cystein melatonin insulin transferrin selenium reveal cystein essenti improv embryo develop melatonin limit impact improv blastocyst rate final observ pig oocyt matur medium supplement pff fli cystein melatonin high proport monosperm zygot low proport polysperm zygot follow ivf yield superior cleavag blastocyst rate | D000975;D008550 | T121;T039;T109;T123;T044;T125 |
36,244,246 | polymer microneedl enhanc drug deliveri cancer therapi microneedl mns attract interest research polymer mns offer tremend promis drug deliveri vehicl bio applic high load capac strong patient adher excel biodegrad biocompat low toxic extrem cheap cost incorpor enhanc properti nanomateri polymer mns matrix increas featur better mechan strength sustain drug deliveri lower toxic higher therapeut effect therefor consider increas biomed applic paper discuss polymer mn fabric techniqu present status polymer mns deliveri method enhanc drug deliveri cancer therapeut applic furthermor opportun challeng polymer mns improv drug deliveri cancer therapi highlight | D009339;D009369 | T191;T074 |
36,244,245 | mechan engin hair follicl regener situ bioprint hair loss caus various factor trauma stress diseas hurt patient psycholog serious affect patient qualiti life effect method control situ bioprint method print bioink direct defect site accord shape characterist defect tissu organ promot tissu organ repair studi appli bioprint machin situ bioprint epiderm stem cell epi scs skin deriv precursor skps matrigel wound nude mice promot hair follicl regener base nativ microenviron result show success regener hair follicl skin appendag week situ bioprint moreov confirm bioprint slight decreas stem cell viabil maintain stem stem cell find demonstr mechan engin method hair follicl regener situ bioprint potenti clinic | D062028 | T063 |
36,244,237 | autom hplc msms assay simultan determin ten plasma antibiot concentr therapeut drug monitor tdm antibiot atb patient serious bacteri infect allow optim efficaci treatment reduc risk toxic notabl earli measur plasma beta lactam concentr shown associ reduc mortal intens care patient context rapid robust accur assay method essenti daili tdm fulli autom procedur quantif plasma concentr ten atb develop atb divid two calibr pool pool aztreonam ceftobiprol cefoxitin avibactam tazobactam pool metronidazol ceftriaxon daptomycin ceftolozan moxifloxacin sampl prepar consist acetonitril plasma protein precipit h dilut appli analyt procedur carri autom sampl prepar system direct coupl liquid chromatographi tandem mass spectrometri lc msms system sinc instrument extract sampl n sampl n lc msms system delay obtain result two sampl correspond analyt run time less min method valid accord food drug administr guidelin method sensit lower limit quantif mgl depend atb accur intraint assay bias precis intraint assay cvs applic tdm assay illustr report intens care patient treat ceftazidimeaztreonamavibactam combin four assay perform day result return within h quick manag dose regimen patient autom simpl rapid robust lc msms analysi develop valid simultan quantif plasma concentr atb appli success perform tdm method provid shorter turnaround time classic sampl batch base analyt method | D000900;D053719 | T121;T063;T195 |
36,244,236 | integr offlin two dimension chromatographi mass defect filter base precursor ion list data acquisit target character diterpenoid alkaloid later root aconitum carmichaelii hyphen techniqu offlin two dimension chromatographi high resolut mass spectrometri ms effici tool separ character compon complex system herbal medicin especi co elut compon isom studi construct ultra perform converg chromatographi upc revers phase rp chromatograph separ system develop mass defect filter mdf base precursor ion list pil acquisit method improv select sensit techniqu systemat character diterpenoid alkaloid later root aconitum carmichaelii name fuzi chines use exampl construct offlin separ system show good orthogon besid hous databas known predict c c diterpenoid alkaloid establish molecular design compound discover softwar ms data match filter two mdf window construct screen potenti diterpenoid alkaloid novel structur obtain pil mass rang even valu da parent mass width mda data acquisit calcul mz valu potenti ion use mass rang correspond mass defect mdf window addit integr structur interpret strategi develop integr element composit analysi ring doubl bond analysi neutral loss filter diagnost ion filter databas match etc result total compon later root carmichaelii expos character includ potenti new compound strategi show signific advantag improv coverag select screen could also appli systemat character compon herbal medicin | D031841;D000470;D004224;D004365;D010946 | T002;T131;T121;T109;T123 |
36,244,235 | chromatograph support enantioselect liquid chromatographi evolut innov trend divers approach explor chromatograph support chiral stationari phase csps liquid chromatographi lc introduct nanoparticl superfici porous particl new materi includ monolith metal organ framework coval organ framework well hybrid chromatograph support nevertheless silica base csps still nowaday success wide appli review relev achiev relat chromatograph support use develop csps lc describ advantag drawback differ materi use chromatograph support critic discuss recent exampl applic also present emphas innov trend lc | D012822;D000073396 | T109;T197 |
36,244,221 | tripl sourc ct system micro scale investig geolog materi simul studi tripl sourc ct system propos micro scale test geolog materi studi aim reduc project acquisit time two third compar convent singl sourc ct system propos system differ posit error sourc object distanc sod simul test use shepp logan phantom model well slice sand glass bead concret sampl furthermor imag qualiti singl sourc tripl sourc ct system differ dead detector pixel compar result show within maximum allow posit error pixel differ simul origin imag close zero structur similar greater presenc dead detector pixel qualiti simul imag tripl sourc ct system superior singl sourc ct system present tripl sourc ct system perform well high qualiti imag reconstruct | D007091;D014057 | T060;T066 |
36,244,214 | high sucros diet modifi brain oxylipin sex depend manner oxylipin implic mani biolog process diseas dysregul cerebr lipid homeostasi alter lipid metabolit associ onset progress dementia although dietari intervent focus modul dietari fat impact high sucros diet brain oxylipin profil unknown | D003704;D061385 | T121;T048 |
36,244,213 | iodo delta lacton inhibit angiogenesi human ht colon adenocarcinoma xenograft sever studi shown antiprolif effect iodin hydroxi iodo eicosatrieno delta lacton il divers tissu demonstr molecular iodin il iodid exert anti neoplast action differ cancer under mechan il inhibit tumor growth remain unclear aim studi analyz effect il tumor growth angiogenesi human ht colorect cancer xenograft | D003110;D000230;D007455 | T191;T196;T123;T121 |
36,244,176 | inhibit uv b stress lettuc enzym like scutellaria baicalensi carbon dot oxid stress plant caus uv b stress alway great challeng yield agricultur product carbon dot cds enzym like activ develop inhibit oxid stress anim achiev littl known abiot stress resist plant especi uv b stress studi cds synthes scutellaria baicalensi via hydrotherm method abil cds scaveng reactiv oxygen speci ros vivo vitro enhanc antioxid resist vivo evalu result show cds promot nutrient assimil abil lettuc seedl protect plant uv b stress increas activ superoxid dismutas sod peroxidas pod catalas cat glutathion reductas gr ascorb peroxidas apx moreov antioxid metabol plant activ cds express level aquaporin aqp gene pip pip also regul result facilit design fabric cds meet challeng abiot stress food product | D018545;D000975 | T002;T121;T123;T168;T044;T039 |
36,244,175 | vivo vitro studi hepatotox tris dibromopropyl isocyanur exposur via mitochondri death receptor pathway tri dibromopropyl isocyan tbc newli bromin flame retard wide use synthesi flame retard materi characterist persist organ pollut obtain environment exposur risk tbc wistar rat hepg cell use vivo vitro studi toxic tbc relev ecotoxicolog mechan apoptosi wistar rat random select divid four exposur group g kgbw tbc half male half femal oral administr day wistar rat exhibit appetit loss weight loss dull hair increas period tbc exposur patholog examin reveal sever damag liver ratio liverbodi weight high dose group gkgbw higher control group femal rat ident trend male rat indic fair consist serum test result confirm liver target organ exposur dosag hepg cell gml individu hepg cell expos tbc h display hazi cell contour decreas densiti cell growth inhibit detect mtt assay maximum inhibit rate dose gml tbc apoptosi rate detect flow cytometri demonstr posit correl exposur dosag tbc apoptosi rate low medium high dose group tbc exposur individu target gene correspond protein express trigger apoptosi vivo vitro signific alter overal work disclos impact tbc exposur hepatotox provid new insight chemic risk assess acceler cell apoptosi via mitochondri death receptor pathway | D056486;D005411 | T047;T120;T037 |
36,244,174 | black phosphorus quantum dot caus glucos metabol disord insulin resist mice black phosphorus quantum dot bpqds consid wide applic prospect due excel properti howev studi effect bpqds glucos metabol studi blood glucos signific increas mice continu intragastr administ mgkg bw bpqds blood glucos level mice elev day day bpqd exposur also decreas area curv auc oral glucos toler test ogtt exposur pancrea somat index increas moreov serum insulin glucagon level elev relat area islet cell increas bpqd expos mice insulin signal cascad reduc muscl tissu summari studi demonstr first time bpqd exposur induc glucos disord insulin resist muscl help understand biosafeti black phosphorus nanomateri promot sustain develop nanotechnolog | D045663;D007333;D061385 | T121;T046;T073 |
36,244,173 | effect polarnon polar facet transform nanoscal zno simul sweat potenti impact antibacteri activ use nanoscal zinc oxid n zno person care product would caus interact n zno human sweat facet engin appli n zno improv activ nevertheless clear whether expos facet would affect transform n zno sweat herein prepar zno nanoneedl domin non polar facet ie zno zno nanoflak domin polar facet ie zno respect found n zno undergo chemic transform simul sweat within h h transform amorph materi zn po h andor na znpo h given rate constant eg h zno vs h zno zno deplet compon precipit simul sweat nevertheless transform high depend domin expos facet n zno zno relat zno would like undergo chemic transform demonstr polar facet compar non polar facet superior activ dihydrogen phosphat anion simul sweat support densiti function theori calcul chemic transform affect antibacteri activ n zno e coli moder toxic due great decreas concentr dissolv zinc total find provid insight facet depend transform n zno simul sweat improv understand potenti risk n zno | D015034 | T121;T197 |
36,244,172 | graphen oxid induc dynam chang autophagi lysosom pathway cell apoptosi via tfeb dysregul f cell extens applic graphen oxid go nanomateri increas risk releas environ thus pose threat human bodi multipl studi indic go could lead neurotox intric biolog effect go astrocyt remain unclear autophag disord consid import part exposur risk go applic neuromedicin studi explor key regul mediat autophag process rat astroglioma deriv f cell caus go especi dynam chang cellular physiolog state time identifi transcript factor eb tfeb critic regul autophagi lysosom pathway alp crucial factor go induc autophagi flux blockad cell apoptosi specif prolong exposur go increas amount cellular intern gradual prevent tfeb enter nucleus therebi lead subsequ alp dysfunct excess cell apoptosi furthermor stip homolog u box contain protein stub e ubiquitin ligas respons go trigger tfeb dysregul overexpress stub help allevi go cytotox studi highlight impair tfeb activ under compromis autophagi flux go induc apoptosi open new avenu applic go base nanotherapeut specif autophagi regul properti central nervous system | D008247;D006108 | T026;T109;T196 |
36,244,171 | respons bacteri communiti uvb signific differ immatur periphyton matur periphyton physiolog indic periphyton import ecolog function even exist environ strong ultraviolet radiat howev knowledg periphyton ultraviolet limit limit understand applic periphyton environ high ultraviolet radiat studi immatur periphyton imp matur periphyton mp ultraviolet b uvb irradi investig compar term physiolog characterist bacteri communiti analysi physiolog characterist show respons pattern imp mp uvb similar imp mp could adapt uvb wm well howev high intens uvb wm reduc periphyton biomass inhibit photosynthesi antioxid enzym activ caus sever lipid peroxid imp mp integr biolog respons ibr analysi toxicolog model fit show ed valu uvb imp mp wm respect rrna gene analysi show imp mp bacteri communiti composit assembl function affect uvb addit respons bacteri communiti imp uvb stronger mp divers imp communiti inhibit uvb mp communiti proteobacteria deinococcus thermus key microorgan respons toler uvb stress neutral communiti model fit show uvb develop process caus determin bacteri success howev uvb may weaken determinist process caus develop function predict show mani metabol function periphyton inhibit uvb imp mp howev uvb caus differ chang enhanc inhibit ecolog function studi provid valuabl inform understand periphyton environ uvb radiat may use improv applic periphyton environ | D000074284 | T001 |
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