PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,241,756 | antimicrobi antioxid activ streptomyc speci soil three differ cold site fez mekn region morocco increas demand new bioactiv compound combat evolut multi drug resist mdr requir research microorgan differ environ order identifi new potent molecul studi initi screen regard antimicrobi activ actinomycet isol isol three soil sampl three differ extrem cold site morocco carri primari secondari screen perform candida albican atcc escherichia coli atcc staphylococcus aureus atcc bacillus cereus atcc clinic mdr bacteria thirteen phytopathogen fungi base result obtain activ isol select studi microbi isol identifi base morpholog biochem charact molecular identif perform use rrna sequenc homolog uv visibl analysi dichloromethan extract five streptomyc sp strain show high antimicrobi antioxid abt dpph activ reveal absenc polyen molecul gc ms analysi dichloromethan extract e activ strain reveal presenc volatil compound includ pyrrolopyrazin benzeneacet acid conclus studi isol new streptomyc strain produc new compound antimicrobi antioxid activ cold microbiolog unexplor region morocco furthermor studi demonstr signific p posit correl total phenol flavonoid content antioxid capac pave way character streptomyc sp isol optim use anticanc antioxid antimicrobi purpos | D000890;D013302 | T121;T007 |
36,241,755 | rapid adsorpt selenium remov use iron manganes base micro adsorb selenium wastewat particular concern due increas concentr high mobil water toxic organ therefor studi carri determin remov effici selenium use iron manganes base bimetal micro composit adsorb bimetal micro composit adsorb synthes use chemic reduct method micro particl character use energi dispers x ray spectroscopi element analysi adsorpt confirm adsorpt selenium surfac micro composit adsorb scan electron microscopi show particl circular shape irregular size brunauer emmett teller result total surfac area particl g zeta particl size result averag particl size nm appli remov selenium ion aqueous system data reveal optimum condit highest remov selenium observ ph adsorb dosag mg contact time min respect initi concentr ppm langmuir freundlich isotherm model match experiment data well result prove bimetal micro composit could use effect selenium adsorb due high adsorpt capac short adsorpt time need achiev equilibrium regard reusabl bimetal absorb adsorpt desorpt percentag decreas respect st rd cycl | D012643;D014874 | T121;T131;T123;T196 |
36,241,753 | unweav popul structur genet divers canadian shrub willow perenni shrub willow increas promot short rotat coppic system biomass feedstock phytoremedi applic divers ecosystem servic accru renew interest led widespread willow cultiv particular non nativ varieti howev canadian willow speci wide adopt inher divers yet thorough investig studi genotyp salix famelica salix eriocephala collect site origin analyz use singl nucleotid polymorph reveal pattern popul structur genet divers analys bayesian method princip compon analysi detect five main cluster appear larg shape geoclimat variabl includ mean annual precipit number frost free day overal observ h expect h e heterozygos respect analysi molecular varianc reveal highest genet variat occur within genotyp variat exist among cluster genotyp within cluster find provid new insight extent genet variat exist within nativ shrub willow speci could leverag pan canadian willow breed program | D032108 | T002 |
36,241,749 | investig radiom base intra patient inter tumor heterogen impact tumor subsampl strategi radiom analysi appli local cancer diseas applic metastat set involv non exhaust lesion subsampl strategi may sidestep intrapati tumor heterogen hinder reproduc therapeut respons perform aim evalu radiom featur captur intertumor intrapati heterogen impact tumor subsampl comput heterogen end delin extract radiom featur visibl tumor singl acquisit pre treatment comput tomographi patient metastat lung cancer cohort l confirm result larger cohort patient metastat melanoma cohort quantifi captur heterogen absolut coeffici variat cv radiom index calcul patient level sensit analysi perform use subset extract featur robust segment step extent inform loss six common use tumor sampl strategi assess total lesion segment patient median age femal robust radiom index exhibit least variat signific heterogen heavili oligo metastas patient also organ level none segment subsampl strategi abl recov true tumor heterogen obtain exhaust tumor sampl imag base inter tumor intra patient heterogen success grasp radiom analys fail take account kind heterogen lead inconsist predict algorithm guidelin standard tumor sampl step andor ai driven tool allevi segment effort requir | D008175;D008545;D014057 | T191;T060 |
36,241,744 | herc defici activ c rafmkkp signal pathway alter cellular respons oxid stress herc gene encod e ubiquitin ligas involv sever cellular process regul ubiquityl differ protein substrat biallel pathogen sequenc variant herc gene associ herc angelman like syndrom pathogen herc variant complet absenc mark reduct herc protein level observ common patholog variant cc pproleu encod unstabl herc protein better understand patholog herc variant affect intracellular signal may aid definit potenti new therapi disord purpos studi patient deriv cell herc proleu variant observ alter mitogen activ protein kinas signal pathway reflect increas level c raf protein p phosphoryl herc knockdown experi reproduc effect human mous cell moreov demonstr herc raf protein form molecular complex pull proteom experi show herc regul c raf ubiquityl found p activ due herc deplet occur rafmkk depend manner display cellular respons patient deriv human cell herc defici show higher resist oxid stress increas master regul antioxid respons nrf target gene resist independ p abolish raf p inhibitor altogeth find identifi activ c rafmkkp signal pathway herc angelman like syndrom highlight inhibit raf activ potenti therapeut option individu affect rare diseas | D019908;D016159 | T126;T116;T123 |
36,241,735 | natur polymorph zmice contribut amino acid metabol impact cold toler maiz cold stress negat affect maiz zea may l growth develop yield metabol adjust contribut adapt maiz cold stress show transcript factor induc cbf express zmice play promin role reprogram amino acid metabolom cold respons cor gene cold stress maiz deriv amino acid glutamateasparagin gluasn induc burst mitochondri reactiv oxygen speci suppress cold mediat induct dehydr respons element bind protein zmdreb gene impair cold toler zmice block negat regul cold toler direct repress express key gluasn biosynthesi gene asparagin synthetas moreov zmice direct regul express dreb natur variat zmice promot determin bind affin transcript activ zmmyb posit regul cold toler maiz result differ degre zmice transcript cold toler across inbr line studi thus unravel mechan cold toler maiz provid potenti target engin cold toler varieti | D003313;D018506 | T045;T168;T002 |
36,241,733 | concert expans contract immun receptor gene repertoir plant genom recent report suggest cell surfac intracellular immun receptor function synergist activ robust defenc pathogen whether co evolv unclear determin number cell surfac intracellular immun receptor speci surpris number receptor gene predict encod cell surfac intracellular immun receptor strong correl suggest consist mutual potenti immun initi cell surfac intracellular receptor reflect concert co evolut size repertoir across plant speci | D018745;D010944 | T002;T028 |
36,241,731 | cytosol thiol peroxidas prxiib intracellular sensor h regul plant immun redox relay rapid product h hallmark plant respons divers pathogen play crucial role signal downstream various receptor perceiv immunogen pattern howev mechan plant sens h regul immun remain poor understood show endogen h generat upon immun activ sens thiol peroxidas prxiib via oxid cys essenti stomat immun pseudomona syringa show immun stimul cell prxiib conjug via cys type c protein phosphatas aba insensit abi subsequ transduc h signal abi oxid dramat sensit h mediat inhibit abi phosphatas activ vitro requir stomat immun plant togeth result illustr redox relay prxiib sensor h abi target protein mediat reactiv oxygen speci signal plant immun | D029681;D017360 | T116;T002 |
36,241,722 | assess solar e cooker social accept gaza strip studi aim assess social accept use solar energi base cook applianc gaza strip studi sampl consist employe three local univers gaza strip target studi meanwhil particip particip studi give conclus studi margin error confid level differ attribut use measur social accept respond solar energi cook system includ knowledg use solar cook applianc financi situat educ level age career gender accord result particip believ best usag solar energi light meanwhil particip support usag solar energi cook also conclud statist signific differ use solar energi cook associ gender job status meanwhil found statist signific use solar energi cook associ educ age show clear behavior barrier usag solar energi cook system gaza strip accord research conclud end user middl incom put qualiti life first technolog cost afford cost conclus regardless educ level respond moreov found fund scheme loan key issu spread e cook final conclud notic support use solar energi gaza accord research direct associ energi poverti status gaza meanwhil idea use green altern energi accept gaza clear lack awar technolog aspect characterist | D006794;D011788 | T078;T073 |
36,241,713 | rapid accur quantif isomir rt qpcr current microrna mir annot singl defin sequenc canon even though high throughput small rna sequenc identifi mir isoform isomir differ canon counterpart length sequenc describ simpl revers transcriptas quantit polymeras chain reaction rt qpcr base assay quantif mir pisop variant chose mir p canon sequenc underrepres evalu human plasma quantif mir piso p plasma sampl demonstr high concord high throughput rna sequenc rt qpcr result r p note could detect quantifi mir p plasma sampl use commerci taqman canon mir p rt qpcr kit sampl also adapt assay specif quantifi canon sequenc mir p mir p similar result obtain mir pisop rt qpcr result mir p mir p high correl high throughput rna sequenc data mir p r p mir p r p assay describ easili adapt mani differ identifi isomir high specif isomir reliabl rt qpcr base quantif could provid greater resolut higher accuraci use canon sequenc | D035683 | T123;T114 |
36,241,699 | nave pluripot like characterist non tumorigen muse cell isol human amniot membran multilineag differenti stress endur muse cell non tumorigen pluripot like stem cell exhibit triploblast differenti self renew singl cell level collect pluripot surfac marker ssea bone marrow bm peripher blood organ connect tissu ssea cell human amniot membran mesenchym stem cell hamsc compar hbm muse cell similar hbm muse cell hamsc ssea cell express pluripot gene oct nanog sox differenti triploblast cell singl cell self renew exhibit non tumorigen notabl howev exhibit uniqu characterist seen hbm muse cell includ higher express gene relat germlin extraembryon cell lineag compar hbm muse cell singl cell rna sequenc enhanc express marker relev germlin prdm tfapc nano extraembryon cell cdx gcm id lineag induc cytokin subset suggest broader differenti potenti similar nave pluripot stem cell sne dimension reduct gene ontolog analysi visual hamsc ssea cell compris larg undifferenti subpopul epitheli mesenchym cell state small mesenchym subpopul express gene relev placent format easili access noninvas approach uniqu cell potenti interest target nave pluripot stem cell like resourc without tumorigen | D000527;D000650 | T121;T109;T018 |
36,241,698 | terror relat injuri somalia retrospect cohort hospit case along year terror relat injuri death becom major threat somalian popul rest world aim character compar firearm explos injuri caus terrorist act retrospect studi review data patient injur explos firearm attack seven year epidemiolog characterist injuri pattern sever score hospit resourc util paramet length stay death rate evalu total patient injur explos firearm attack studi period eighti one percent patient n male case femal multipl bodi site injuri occur frequent explos injuri firearm wound p relat frequenc intern injuri explos injuri higher firearm wound vs patient injur due explos greater rate sever critic injuri injur firearm vs p quarter patient hospit intens care unit inpati mortal rate find studi reveal suicid bomb explos associ multipl bodi site injuri greater rate sever critic intern injuri higher mortal rate | D001753;D009104;D023481 | T054;T037 |
36,241,695 | comprehens transcriptom comparison hepatocyt model system improv select model experiment use myriad avail hepatocyt vitro model provid research possibl select hepatocyt like cell hlcs specif research goal howev direct comparison hepatocyt model current challeng systemat search literatur compar differ hlcs report function limit small subset hepat function enabl comprehens comparison develop algorithm compar transcriptom data across studi test hlcs deriv hepatocyt biliari cell fibroblast pluripot stem cell alongsid primari human hepatocyt phhs reveal hlc cover complet hepat transcriptom highlight import hlc select hlcs deriv hepatocyt highest transcript resembl phhs regardless protocol wherea qualiti fibroblast psc deriv hlcs vari depend protocol use final develop valid web applic hlcompr enabl comparison specif pathway addit new hlcs conclus comprehens transcriptom comparison hlcs allow select hlcs specif research question guid improv cultur condit | D057026;D039904 | T025 |
36,241,694 | meta analysi relationship bulli non suicid self injuri among children adolesc non suicid self injuri nssi attract increas attent due high detect rate high risk high repeat need earli identif prevent occurr factor necessari facilit screen intervent especi facilit earli detect high risk individu research aim investig relationship bulli behaviour non suicid self injuri among children adolesc mean meta analysi pubm embas web scienc scopus psycinfo ckni wan fang databas search incept decemb studi explor relationship bulli behaviour nssi among children adolesc total articl met inclus criteria meta analysi independ effect size obtain includ subject victim ci p bulli ci p bulli victim ci p like nssi uninvolv children adolesc addit analys show absenc public bias victim group older age lower risk nssi z p gender play moder effect associ bulli behaviour non suicid self injuri relationship involv bulli nssi demonstr take measur prevent bulli incid nssi children adolesc potenti reduc | D000294;D058445;D019548;D016728 | T098;T055;T068;T048 |
36,241,693 | synchrotron imag muscl tissu differ atroph stage stroke spinal cord injuri proof concept studi synchrotron x ray comput tomographi sxct allow imag tissu larg field view excel micron resolut enabl investig muscl fiber atrophi studi aim explor micro architectur healthi skelet muscl fiber muscl fiber differ stage atrophi stroke sampl muscl atrophi spinal cord injuri sci sampl sever muscl atrophi three muscl sampl healthi control sampl stroke sampl atroph sampl sci sampl sever atroph sampl imag use sxct muscl fiber popul segment quantifi microarchitectur morpholog differ volum fraction muscl fiber healthi stroke atroph sci sever atroph muscl fiber popul sampl respect sci sever atroph sampl imag analysi reveal fiber split fiber swell stroke sampl atroph sampl muscl fiber buckl observ visibl analysi muscl fiber popul analysi reveal new insight differ stage muscl fiber atrophi observ quantifi histolog analysi includ fiber buckl loss fiber fiber split | D013119;D020521 | T047;T037 |
36,241,691 | profil gut microbiota serum metabolit associ metabol syndrom remot island afflict obes japan numer studi reveal distinct differ profil gut microbiota non obes obes individu date howev littl known dispar communiti gut microbiota exist metabol healthi obes mho metabol unhealthi obes muo subject therefor aim comprehens character gut microbiota circul metabolit serum mho muo resid remot island kumejima preval obes one highest japan explor possibl correl gut microbiota profil marker metabol syndrom result reveal muo show signific higher level genera gsuccinivibrio ggranulicatella gbrachyspira goribacterium gatopobium comparison mho moreov abund gsuccinivibrio gbrachyspira gatopobium posit correl valu fast insulin homa r circul triglycerid diastol blood pressur bmi bodi weight waist circumfer hbac addit muo compar mho show imbal serum metabolit signific elev oxoisovaler acid pyruv acid hydroxybutyr acid creatin data highlight unmet need precis approach treatment obes target gut microbiota profil serum metabolit distinct popul affect obes | D000069196;D061385;D024821 | T007;T001;T047;T121 |
36,241,689 | tran oral tran sheath forcep biopsi patient sever esophag obstruct fluoroscopi investig safeti effect tran oral tran sheath forcep biopsi ttfb patient sever esophag obstruct fluoroscopi novemb novemb patient level iii iv dysphagia karnofski score less enrol undergo ttfb esophag nutrit tube insert stent simultan data diagnost perform earli complic radiat dose collect karnofski score procedur compar technic success ttfb sensit specif accuraci respect complic occur two case mean procedur durat irradi dose min msv respect karnofski score signific increas week p ttfb safe effect method patient sever esophag obstruct fluoroscopi especi undergo refus endoscopi | D004938;D004940 | T191;T047 |
36,241,688 | estim r spread sar cov germani excess mortal sar cov r calcul rang domin literatur much higher estim also publish capac rt pcr test increas great earli phase covid pandem r determin base incid valu subject strong bias propos use covid induc excess mortal determin r regardless rt pcr test capac use data robert koch institut rki incid covid case covid relat death number rt pcr test perform excess mortal calcul data feder statist offic germani determin r use exponenti growth estim serial interv day use dataset yet influenc polici measur eg lockdown school closur uncorrect r valu spread sar cov base rt pcr incid data ci covid case ci covid relat death howev number rt pcr test increas growth factor period r valu must correct accord rcorrect runcorrect yield covid case covid death r valu base excess death calcul ci sine function base adjust season effect correspond maximum valu r januari minimum valu r juli calcul show r much lower previous thought relat low rang r fit well observ season pattern infect across europ includ emerg contagi escap variant delta omicron general studi show excess mortal use reliabl surrog determin r pandem situat | D050936;D000086382 | T067;T047;T081 |
36,241,687 | arsenic remov perform mechan water iron hydroxid nanopetalin human health serious endang arsenic pollut drink water paper iron hydroxid nanopetalin synthes precipit method use kbh perform mechan v iii remov investig prepar materi character sem edx xrd bet zeta potenti ftir analys batch experi indic iron hydroxid nanopetalin exhibit excel perform v iii remov ferrihydrit adsorpt process fast first stage follow relat slower adsorpt rate reach equilibria h reaction could fit best pseudo second order model follow elovich model adsorpt isotherm data follow freundlich model maxim adsorpt capac v iii calcul langmuir model mgg ph respect wherea valu mgg ph respect thermodynam studi indic adsorpt process endotherm spontan remov effici v iii signific affect solut ph presenc po citrat reusabl experi show remov effici v could easili recov four cycl sem xrd analys indic surfac morpholog crystal structur arsenic remov stabl base analys ftir xrd xps predomin adsorpt mechan format inner sphere surfac complex surfac hydroxyl exchang reaction fe oh group arsenic speci research provid new strategi develop arsenic immobil materi result confirm iron hydroxid nanopetalin could consid promis materi remov arsenic contamin water high effici perform stabil | D001151;D060766;D014874;D018508 | T052;T167;T131;T121;T057;T196 |
36,241,686 | effect surfac coverag alkyl carboxyl acid monolay waterborn cellular uptak behavior silicon quantum dot articl report develop high waterborn silicon quantum dot si qds termin reactiv group graft biomolecul hydrogen termin qds prepar thermal disproportion amorph hydrogen silsesquioxan deriv triethoxysilan follow hydrofluor etch next hydrogen si surfac expos undeceno acid differ temperatur ar atmospher yield termin qds carboxyl group thermal hydrosilyl undeceno acid yield termin qds carboxyl group increas molecular coverag undecano acid ua monolay result enhanc increas zeta potenti negat direct greater water dispers increas absolut quantum yield qy photoluminesc pl plqi improv increas ua coverag assess molecular interact ua siqd hela cell mean cellular uptak experi use qds differ ua coverag result show qds highest dispers water intern cell confoc fluoresc microscop observ contrast qds lower coverag ua monolay intern endocytosi incub hela cell contrast observ open possibl success prepar carboxi cap siqd allow cellular uptak target specif cell appropri conjug biomolecul | D045663 | T073 |
36,241,685 | pro oxid combin resveratrol copper regul multipl biolog hallmark age neurodegener mice billion cell die bodi everi day cell free chromatin particl cfchps releas enter extracellular compart bodi includ circul cfchps known readili enter healthi cell damag dna activ apoptot inflammatori pathway hypothes lifelong assault healthi cell cfchps under caus age age could retard deactiv extra cellular cfchps latter effect oxygen radic generat upon admix nutraceut resveratrol copper r cu present studi investig whether prolong administr r cu would retard biolog hallmark age cbl mice divid equal group one group sacrif age month act young control remain mice allow age age month experiment age group given r cu oral gavag twice daili month dose mgkg r gkg cu control age group given water oral gavag twice daili month anim group sacrif age month r cu treatment led reduct sever biolog hallmark age brain cell includ telomer attrit amyloid deposit dna damag apoptosi inflamm senesc aneuploidi mitochondri dysfunct r cu treatment also led signific reduct blood level glucos cholesterol c reactiv protein find suggest cfchps may act global instig age neurodegener therapeut use r cu may help make healthi age attain goal | D002097;D003300 | T116;T121;T196;T123;T129 |
36,241,684 | construct intern valid novel nomogram predict prognosi infect endocard develop nomogram predict model capabl earli identif high risk infect endocard ie patient retrospect analyz clinic data patient ie divid surviv non surviv group accord differ hospit outcom univari multivari logist regress method use screen independ risk factor affect surviv outcom ie nomogram predict model construct factor hosmer lemeshow good fit test appli assess model fit discrimin calibr model evalu plot roc curv calibr curv advanc age embol symptom abnorm leukocyt count low hemoglobin level doubl side ie associ higher hospit mortal patient ie p hosmer lemeshow good fit test model p auc roc curv model ci bootstrap method use valid predict model result show predict accuraci model valid cohort nomogram predict model accur predict hospit mortal risk ie help clinician identifi high risk ie patient earli | D004696;D004697 | T047 |
36,241,683 | prognost factor treatment meniscus horizont tear meniscus horizont tear usual degen could asymptomat unrel knee symptom therefor controversi regard treatment choic aim studi evalu factor affect result non surgic surgic treatment meniscus horizont tear retrospect studi patient meniscus horizont tear minimum year follow period patient treat non surgic arthroscop treatment result dichotom success failur factor consid age sex joint line tender mechan symptom widest tear gap width sagitt mri cartilag lesion grade discoid meniscus tear site joint align joint align cartilag lesion grade factor signific influenc non surgic treatment result widest tear gap width cartilag lesion grade signific affect arthroscop surgeri result mechan symptom show signific relationship either treatment result treat patient meniscus horizont tear patient varus align advanc cartilag lesion inform possibl poor outcom non surgic treatment patient wide tear gap minim cartilag lesion arthroscop surgeri would good treatment choic mechan symptom adequ factor arthroscop surgeri | D000072600;D000070600 | T023;T037 |
36,241,682 | anthropogen microparticl emerald rockcod trematomus bernacchii nototheniida antarct anthropogen microparticl am found first time specimen trematomus bernacchii collect ross sea antarctica store antarct environment specimen bank identifi am fiber natur synthet origin natur am cellulos synthet one polyest polypropylen polypropylenepolyest cellulos acet presenc dye natur am indic anthropogen origin five industri dye identifi raman spectroscopi indigo occur research add data ongo knowledg pollut level antarct ecosystem provid interest snapshot past highlight microplast anthropogen fiber pollut alreadi enter antarct marin food web end find therefor establish foundat understand chang marin litter pollut time | D017753;D010473 | T082;T013;T070 |
36,241,681 | first serolog evid q fever larg rumin associ risk factor punjab pakistan coxiellosi also known q fever zoonot diseas caus coxiella burnetii gram negat bacterium exert signific deleteri impact product reproduct capabl livestock sever effect econom sector studi sera sampl cattl n buffalo n collect farm pakistan examin antibodi c burnetii use indirect elisa tick also collect anim serolog analysi reveal seropreval q fever cattl buffalo respect odd ratio analysi factor associ c burnetii seroposit perform multivari logist model identifi five main variabl associ seroposit coxiellosi absenc acaricid use ci ii presenc tick ci iii abort histori preced year farm ci iv presenc sheep goat ci v absenc separ parturit area ci studi provid new insight seropreval q fever larg rumin across seven studi district punjab pakistan also provid baselin data inform improv herd manag farm practic prevent control q fever larg rumin region result work suggest molecular investig coxiellosi warrant provid thorough evalu c burnetii epidemiolog pakistan | D056810;D015511;D011778;D012757;D013987 | T047;T109;T131;T204 |
36,241,680 | effect super class cannabi terpen beta caryophyllen alpha pinen zebrafish behaviour biomark terpen possess wide rang medicin properti potenti therapeut varieti patholog condit studi investig acut effect two cannabi terpen caryophyllen pinen zebrafish locomot anxieti like bold behaviour use open field explor novel object approach test caryophyllen administ dose pinen administ dose pinen racem compound also test enantiom observ differenti effect caryophyllen sedat effect highest dose test pinen differ dose depend effect anxieti like motor variabl specif pinen pinen signific effect anxieti measur time spent thigmotaxi outer center zone open field test well locomotor variabl swim veloc immobl pinen show small effect open field test immobl dose studi demonstr pinen sedat anxiolyt effect zebrafish may differ medicin properti isol enantiom | D014151;D002188;D006213 | T002;T167;T131;T121;T109;T039 |
36,241,679 | massiv expans multipl clone mous hematopoiet system long whole bodi x irradi clonal hematopoiesi ch preval elder associ hematolog malign cardiovascular diseas although risk develop diseas increas radiat dose atom bomb survivor causal relationship radiat exposur ch unclear studi investig whether radiat exposur induc ch mice month gy whole bodi irradi found radiat associ increas peripher blood myeloid cell red blood cell distribut width rdw deep sequenc bone marrow non hematopoiet tissu cell reveal recurr somat mutat specif hematopoiet system irradi mice none non irradi mice irradi mice possess mutat variant allel frequenc vaf averag per mous mutat vaf andor delet preval examin hematopoiet stemprogenitor cell two irradi mice reveal sever mutat co exist clone multipl independ clone deliv bone marrow nuclear cell result indic develop massiv ch due radiat exposur moreov character mutat radiat induc ch | D006412;D014916 | T061;T025 |
36,241,678 | spatio tempor distribut hotspot plasmodium knowlesi infect sarawak malaysian borneo plasmodium knowlesi infect malaysia new threat public health nation effort malaria elimin kapit divis sarawak malaysian borneo two diverg p knowlesi subpopul term cluster cluster infect human associ long tail macaqu pig tail macaqu host respect suggest forest associ activ environment modif trigger increas number knowlesi malaria case sinc steadi increas p knowlesi infect past decad sarawak particular kapit divis aim identifi hotspot knowlesi malaria case associ forest activ geograph scale use geograph inform system gis tool total p knowlesi infect kapit song district kapit divis studi overal demograph data show male age year old frequent infect infect involv farm activ thirti nine percent cluster infect main relat farm surround residenti area cluster infect associ activ deep forest averag nearest neighbour ann analysi show human infect p knowlesi subpopul exhibit cluster distribut pattern infect kernel densiti analysi kda indic hotspot infect surround kapit song town classifi high risk area zoonot malaria transmiss studi provid use inform staff sarawak state vector born diseas control programm effort control prevent zoonot malaria | D008288;D016790 | T047;T204 |
36,241,677 | character gh endoxylanas penicillium funiculosum synerg gh endo glucanas saccharif sugarcan bagass product second generat fuel lignocellulos residu sugarcan bagass scb requir synergist interact key cellulos degrad enzym accessori protein complet deconstruct use monomer sugar recombin express character unknown gh xylanas p funiculosum pfxyn pichia pastori earlier found studi high implic scb saccharif pfxyn molecular mass kda show broad activ rang substrat like xylan xyloglucan laminarin p nitrophenyl xylopyranosid highest specif activ umg xylan ph c analysi degrad product xylan scb pfxyn show signific product xylooligosaccharid xos degre polymer dp rang two dp six dp thus suggest pfxyn endo act enzym enzym synergist improv saccharif scb combin crude cellulas cocktail p funiculosum degre synerg pfxyn express individu simultan notabl gh endoglucanas pfegl catabolit derepress strain p funiculosum pfmig saccharif effici secretom result transform investig scb secretom pfmig overexpress xyn egl increas saccharif scb respect secretom pfmig secretom dual transform increas scb saccharif minim protein concentr | D002480;D031786 | T121;T126;T116;T002 |
36,241,676 | canopi arthropod declin along gradient oliv farm intensif arthropod declin link agricultur intensif howev inform impact intensif still limit mani crop understand respons differ arthropod taxa trophic group thus hinder develop effect mitig measur investig impact oliv farm intensif canopi dwell arthropod mediterranean region intensif involv increas use agrochem mechanis irrig also structur chang tradit orchard low densiti larg old tree intens superintens orchard high high densiti smaller younger tree respect canopi arthropod vacuum sampl site repres three orchard intensif level spring summer autumn evalu arthropod communiti vari across intensif level respons orchard structur manag landscap context found chang divers arthropod taxa across intensif level correct sampl coverag arthropod abund declin mark along intensif gradient decreas abund associ chang orchard structur lower herbac cover higher herbicid insecticid use abund special oliv pest lower landscap higher woodland cover negat effect intensif stronger spring summer autumn parasitoid predat particular affect overal result suggest retain herbac cover reduc agrochem input preserv natur woodi element landscap may contribut mitig impact oliv farm intensif canopi arthropod particular benefici speci | D001181;D006540;D007306;D031658 | T002;T131;T168;T204 |
36,241,675 | method refer data middl ear transfer function human tempor bone specimen use experi measur sound transfer middl ear standard method use develop activ passiv middl ear implant statist analys experi usual requir tb sampl repres popul non patholog middl ear specif mean specimen must mechan well character present depth statist analysi data set middl ear transfer function metf differ laboratori data set preprocess various contribut varianc data evalu deriv statist rang refer individu metf measur may valid rang calcul two side toler interv audiolog frequenc addit mean confid interv mean given refer assess valid sampl group final provid suggest procedur measur metf use method describ herein | D009998 | T074 |
36,241,674 | autom detect pain level use deep featur extract shutter blind base dynam size horizont patch facial imag pain intens classif use facial imag challeng problem comput vision research work propos patch transfer learn base model classifi various pain intens use facial imag input facial imag segment dynam size horizont patch shutter blind lightweight deep network darknet pre train imagenetk use generat deep featur shutter blind undivid resiz segment input facial imag discrimin featur select deep featur use iter neighborhood compon analysi fed standard shallow fine k nearest neighbor classifi classif use tenfold cross valid propos shutter blind base model train test dataset deriv two public databas univers northern british columbia mcmaster shoulder pain express archiv databas denver intens spontan facial action databas compris four pain intens class label human expert use valid facial action code system methodolog shutter blind base classif model attain overal accuraci rate dataset excel perform suggest autom pain intens classif model deploy assist doctor non verbal detect pain use facial imag various situat eg non communic patient surgeri system facilit time detect manag pain | D000465;D005145 | T170;T029 |
36,241,672 | boundari condit like bias moral charact judgment recent research shown moral charact judgment prone like bias well like peopl seen moral superior dislik neutral one howev whether moral inform past behavior would moder like bias still open empir question address present studi studi n particip updat bias moral charact impress moral inform target introduc like induct preregist studi n moral inform target present like induct moral inform stronger impact moral charact judgment like studi n show moral charact impress updat three time greater moral inform present vs attitud induct analys chang particip moral judgment certainti reveal moral inform reduc uncertainti stronger attitud effect latter amen updat inform base judgment thus present evid moral inform updat moral charact impress bias like nevertheless like also lesser extent updat moral charact impress initi ground moral inform propos certainti other moral charact explain moral inform limit impact attitudin influenc moral charact judgment | D007600;D009014 | T078;T041 |
36,241,671 | optic nerv sheath diamet associ outcom sever covid neurolog symptom common covid cerebr edema shown post mortem mechan behind unclear elev intracrani pressur icp extens studi covid icp estim noninvas measur optic nerv sheath diamet onsd perform cohort studi onsd ultrasound measur sever case covid intens care unit icu measur onsd ultrasound adult sever covid icu karolinska univers hospit sweden patient classifi either normal elev onsd compar icu length stay icu los day mortal group patient includ elev onsd patient elev onsd day longer icu los ci p risk ratio icu los day signific differ baselin data day mortal group elev onsd common sever covid associ advers outcom may caus elev icp clinic import find need consid decid upon various treatment strategi | D000086382;D019586 | T047;T067;T033 |
36,241,670 | diagnost perform convolut neural network dental sexual dimorph convolut neural network cnn led import solut field comput vision recent forens scienc benefit resourc artifici intellig especi procedur normal requir oper depend step forens tool sexual dimorph base morpholog dental trait avail limit perform studi aim test applic machin learn setup distinguish femal male use dentomaxillofaci featur radiograph dataset sampl consist panoram radiograph n individu age interv year imag annot perform v softwar vlab london uk scratch fs transfer learn tl cnn architectur compar diagnost accuraci test use tl perform better fs correct classif femal male age year respect femal male year correct classif respect area curv auc receiv oper characterist roc curv show high classif accuraci radio diagnost use cnn sexual dimorph show posit outcom promis forens applic field dental human identif | D001185;D012727 | T090;T066;T073;T032 |
36,241,669 | aminoglycosid use risk acut kidney injuri patient without prior chronic kidney diseas outcom acut kidney injuri aki result aminoglycosid ag use remain uncertain patient without prior chronic kidney diseas ckd therefor explor outcom ag use aki episod associ renal recoveri progress patient without prior ckd taiwan retrospect cohort studi use taipei medic univers research databas januari decemb individu without ckd receiv parenter ag enrol expos unexpos group underw propens score match age gender patient intens care unitemerg admiss covari except serum hemoglobin albumin level identifi expos group patient use ag median age year male unexpos group patient without ag use median age year male risk aki stage adjust hazard ratio hr confid interv ci p patient use ag comparison control subject moreov patient use ag signific associ neither progress acut kidney diseas akd stage progress end stage renal diseas esrd dialysi analyz increas risk aki episod serum albumin level less gdl hemoglobin level less gdl among patient without prior ckd ag use individu associ aki risk especi relat low albumin gdl low hemoglobin gdl could rais awar ag prescript patient clinic practic | D058186;D051436 | T047;T037 |
36,241,668 | overcom non kinet activ egfr use multi function mesopor silica nanocarri vitro deliveri sirna tripl negat breast cancer tnbc respond target hormon base medicin epiderm growth factor receptor egfr common overexpress tnbc case target cancer cell via receptor could emerg favor modal tnbc therapi due target specif develop mesopor silica nanoparticl msns carrier sirna remain rapid grow area research purpos multi function kit contain guanidinium ionic liquid guil pei pegyl folic acid fa peg design accord kit fabric modifi fa peg pei polym attach surfac guil place mesopor subsequ confirm structur multi function kit base nanocarri use tem sem afm bet bjh dls zeta potenti investig upload transfer anti egfr sirna md mba cell line rate cellular uptak cellular local endolysosom escap evalu base fluoresc intens fam label sirna use flowcytometri analysi confoc laser scan microscopi clsm cellular uptak h incub clear suggest success deliveri sirna cell clsm demonstr sirna fa pegylatedpei guil kit may escap endosom entrap h incub use qpcr quantit evalu egfr gene express knockdown found result function chang express egfr target co treatment chemotherapi drug carboplatin combin sirna fa pegylatedpei guil kit exhibit remark cytotox effect comparison carboplatin alon | D052578;D053758;D064726 | T191;T103;T073;T120 |
36,241,666 | brain oscillatori activ adolesc idiopath scoliosi pathophysiolog adolesc idiopath scoliosi ai yet complet understood exploratori studi aim investig two aspect neglect clinic practic defect postur central nervous system control ai alter bodi schema due scoliosi spinal deform record eeg data balanc data four differ stand posit adolesc ai control adapt imag mark procedur imp assess bodi schema alter horizont bodi percept indic bpis vertic direct interacromi bisiliac axe inclin result reveal differ balanc control group higher eeg alpha relat power sensorimotor area ipsilater side curv signific increas theta relat power local central area adolesc ai differ bpi shoulder bpi waist signific differ two group inclin perceiv interacromi axe adolesc ai opposit real inclin increas theta activ alpha later observ may compensatori strategi overcom sensorimotor dysfunct mirror alter bodi schema scoliosi onset might preced sensorimotor control impair last curv progress | D007738;D012600;D066191 | T047;T190;T023 |
36,241,665 | novel approach measur brain brain spatial tempor align posit empathi empathi defin abil vicari experi other suffer vicari pain feel joy vicari reward neuroimag studi focus vicari pain describ similar neural respons observ person negat affect involv initi evid report neural respons other reward posit empathi propos novel approach base simultan record multi subject eeg signal exploit wavelet coher decomposit measur tempor align erp dyad interact subject use third parti punish tpp paradigm elicit person vicari experi posit experi observ simultan presenc agent late posit potenti lpp erp compon relat emot process well exist inter subject erp synchron relat time window moreov amplitud lpp synchron modul presenc human agent final local brain circuit subtend erp synchron correspond key region person vicari reward find suggest tempor spatial erp align might novel direct proxi measur empathi | D001921;D004645 | T054;T023;T055 |
36,241,664 | solv mcm paradox visual scaffold cmg helicas activ replisom genom duplic safeguard constant adjust activ replic cmg cdc mcm gin helicas howev minichromosom mainten protein mcms structur core cmg helicas never visual site dna synthesi insid cell call mcm paradox solv conundrum show anti mcm antibodi primarili detect inact mcms upon convers inact mcms cmgs factor requir replisom activ bind mcm scaffold block mcm antibodi bind site tag endogen mcms crispr cas bypass steric hindranc enabl mcm visual activ replisom thus defin condit detect structur core replic cmg helicas result explain mcm paradox provid visual proof mcms integr part activ replisom vivo enabl investig replic dynam live cell expos constant chang environ | D004261;D064110 | T045;T126;T116 |
36,241,663 | novel robust method count compon within bio molecular complex use fluoresc microscopi statist model cellular biolog occur myriad interact divers molecular compon mani assembl specif complex various techniqu provid qualit survey compon found given complex howev quantit analysi absolut number molecul within complex known stoichiometri remain challeng provid novel method combin fluoresc microscopi statist model deriv accur molecular count devis system batch given biomolecul differenti label spectral distinct fluoresc dye label b mix b label molecul vast outnumb label complex contain compon simpli score either posit negat label b frequenc posit complex direct relat stoichiometri interact molecular count infer statist model demonstr method use complex adenovirus particl monoclon antibodi achiev count excel agreement previous estim beyond virolog approach readili transfer experiment system therefor provid power tool quantit molecular biolog | D005456;D015233 | T170;T081;T130 |
36,241,662 | phosphatas protector alpha involv adipocyt mainten mitochondri homeostasi regul insulin signal insulin signal mediat via network protein phosphoryl dysregul network central obes type diabet metabol syndrom investig role phosphatas bind protein alpha essenti serinethreonin protein phosphatas ppa insulin actionresist adipocyt unexpect adipocyt specif inactiv impair insulin induc akt mediat serinethreonin phosphoryl despit decreas protein phosphatas ppa level interest loss also reduc insulin induc insulin receptor tyrosin phosphoryl occur decreas associ box protein result enhanc tyrosin phosphatas protein tyrosin phosphatas b ptpb express moreov adipocyt specif knockout male mice result impair adipogenesi alter mitochondri oxid lead increas inflamm system insulin resist hepatosteatosi islet hyperplasia impair thermogenesi thus box protein ybx mediat pathway insulin receptor signal involv maintain insulin sensit normal adipos tissu homeostasi system metabol | D003924;D007333 | T047;T046 |
36,241,661 | isol character anti prolif polysaccharid north american fungus echinodontium tinctorium novel polysaccharid etgipla purifi fruit bodi echinodontium tinctorium fungus uniqu western north america etgipla estim weight averag molecular weight kda compos glucos galactos mannos fucos glucuron acid rhamnos multipl glycosid linkag glcp glcp glcp glcpa galp galp fucp manp promin unsubstitut glucos mannos fucos major termin sugar etgipla backbon contain most substitut glucopyranos substitut glucopyranosyluron acid etgipla show anti prolif activ multipl cancer cell line ic rang nm flow cytometri analys confirm apoptosi induct one mechan anti prolif activ etgipla investig potenti anti cancer activ anim model possibl util differenti cancer therapi | D001487;D005690 | T109;T123;T004 |
36,241,660 | bee safe peptidomimet acaricid achiev compar genom devast varroa mite varroa destructor anderson trueman obligatori ectoparasit honey bee contribut signific coloni loss north america throughout world limit number convent acaricid reduc varroa mite prevent diseas honey bee coloni challeng wide spread resist low target site select propos biorat approach use compar genom develop honey bee safe select acaricid target varroa mite specif neuropeptiderg system regul proctolin lack honey bee proctolin high conserv pentapeptid rylpt arg tyr leu pro thr known act g protein coupl receptor elicit myotrop activ arthropod speci total differ peptidomimet peptid variant test varroa mite proctolin receptor ligand dock model mutagenesi studi reveal import core aromat residu tyr proctolin ligand peptidomimet observ signific oral toxic lead paralysi death varroa mite negat effect observ honey bee demonstr taxon specif physiolog target identifi advanc genom inform offer opportun develop varroa mite select acaricid henc expedit translat process | D056810;D057786;D057077 | T121;T109;T131;T204 |
36,241,659 | timeless key gene mediat thrombogenesi covid antiphospholipid syndrom abnorm coagul increas risk thrombosi symptom associ covid sever anti phospholipid antibodi apl present critic ill covid patient contribut system thrombosi aim studi identifi key common gene character genet crosstalk covid antiphospholipid syndrom ap use bioinformat analysi explor novel mechan immun mediat thrombosi critic ill covid patient transcriptom data mononuclear cell sever covid patient ap patient evalu obtain common gene protein protein interact network cytohubba modul analysi cytoscap softwar use find associ hing gene hub gene among common differenti express gene timeless deplet identifi patient sever covid patient mild covid valid gse dataset function analys use gene ontolog term kyoto encyclopedia gene genom pathway suggest timeless might contribut product antiphospholipid antibodi thrombosi covid ap patient potenti role timeless autophagi gene momonuclear cell investig gskb found associ timeless autophagi target agent therapeut potenti covid thrombogenesi ap may relat role autophagi gene modif circadian clock protein interfer timeless gene associ regul autoantibodi express may potenti strategi immunotherapi thrombogenesi sever covid patient | D016736;D000086382;D013927 | T047;T046;T067 |
36,241,658 | kir hla gene divers suscept lung cancer killer cell immunoglobulin like receptor kir essenti acquir natur killer nk cell effector function modul balanc net input signal deriv inhibitori activ receptor engag human leukocyt antigen hla class ligand kir hla loci polygen polymorph exhibit substanti variat individu popul attempt investig contribut kir complex hla class ligand genet predisposit lung cancer nativ popul southern iran genotyp kir gene total patient lung cancer healthi control hc among patient hcs taken account evalu combin kir hla associ kirdl ds increas signific patient control individu respect combin hla c ligand respect kird ds like present control absenc relat ligand incid cxtx subset increas lung cancer patient diseas risk strike increas fivefold among genotyp id carrier cxtx genotyp carri dl absenc ds found genotyp ikir akir frequent present lung cancer patient addit patient lung cancer like carri combin cxtxds compar control ikir akir genotyp presenc dl increas likelihood lung cancer develop report new suscept factor contribut kir hla encod gene lung cancer risk highlight array genet effect diseas set regul nk cell respons result suggest inherit kir gene hla ligand specifi educ state nk cell modifi lung cancer risk | D008175;D054340 | T191;T116;T192 |
36,241,656 | next generat whole exom sequenc delin genet basi primari congenit glaucoma delin genet base primari congenit glaucoma pcg ascertain larg cohort consist consanguin famili previous report famili mutat cypb six famili ltbp wherea genet base respons pcg famili remain elus employ next generat whole exom sequenc delin genet basi pcg four famili case exclus linkag report pcg loci establish follow next generat whole exom sequenc perform affect individu manifest cardin system pcg belong four unresolv famili along four control sampl consist genom dnas individu harbor mutat cypb ltbp analys sequenc dataset fail identifi potenti causal allel exom wherea cg p arghi cypb cdelc pglnargf ltbp identifi control sampl taken togeth next generat whole exom sequenc fail delin genet basi pcg famili case exclud mutat cypb ltbp data strengthen notion compound heterozyg code variant non code variant might contribut pcg | D059472;D005901 | T047;T028 |
36,241,655 | identif vivo role erbb jma direct nuclear signal use novel isoform specif knock mous like receptor tyrosin kinas rtks erbb signal canon signal involv phosphoryl cascad howev erbb also signal non canon mechan wherebi intracellular domain releas cytoplasm regul intramembran proteolysi rip transloc nucleus regul transcript differ signal mechan depend generat altern splice isoform rip cleavabl erbb jma uncleav erbb jmb non canon signal erbb jma implic regul brain heart mammari gland lung immun cell develop howev studi non canon erbb signal perform vitro due lack adequ mous model creat erbb jma specif knock mous demonstr rip depend non canon signal erbb jma requir regul gfap express cortic develop also show erbb jma signal requir develop heart mammari gland sensori ganglia furthermor identifi gene whose express cortic develop regul erbb show express three crym dbi depend erbb jma wherea wdfi reli erbb jmb thus provid first anim model direct studi role erbb jma non canon erbb signal vivo | D015398;D014443 | T116;T121;T123;T043;T044 |
36,241,653 | perform comparison fluoresc immunoassay immunochromatographi rapid dengu detect clinic specimen dengu virus denv infect global health threat specif treatment current avail therefor rapid accur diagnosi critic appropri manag could reduc burden sever clinic manifest current dengu immunochromatographi ic common use primarili differenti acut febril ill fluoresc immunoassay fia util high sensit detect system claim sensit specif dengu infect preliminari report report recruit sampl acut febril ill sent dengu screen test ic fia parallel perform test verifi definit diagnosi retriev combinatori revers transcript quantit polymeras chain reaction enzym link immunosorb assay elisa igm igg confirm test result show viral nonstructur protein ns perform fia slight higher ic sensit specif ppv npv agreement kappa standard error respect wherea ic respect moreov igm igg perform fia higher specif ppv agreement igm ic perform suggest fia specif less sensit antibodi detect correl observ igm igg level elisa fia assay conclus fia ic high sensit specif substanti agre ns detect moder agre igm igg detect | D003715;D003716 | T047;T005 |
36,241,651 | multiplex crisprca mediat knockout phytoen desaturas gene coffea canephora coffea canephora n x chromosom speci extens genet divers desir agronom trait coffe breed program howev obtain new coffe cultivar convent breed techniqu may requir year cross cycl select hamper effort keep market demand rapid propos resili climat chang varieti although applic modern biotechnolog tool precis genet engin technolog may enabl faster cultivar develop process therefor aim valid crisprca system generat mutat select genotyp c canephora clone embryogen calli multiplex binari vector contain two sgrnas target differ exon ccpds gene use sgrnas c canephora u promot regul target gene encod phytoen desaturas enzym essenti photosynthesi involv caroten biosynthesi somat seedl embryo albino varieg green phenotyp regener agrobacterium tumefacien mediat genet transform analyz verifi insert cas gene later sequenc sgrnas target region genom robusta modifi seedl among expect mutat least one target homozyg mutat genotyp temperatur co cultiv bacteria light intens use subsequ embryo regener appear strong influenc success regener plant mutat ccpds gene coffea genus | D040503 | T002 |
36,241,650 | intestin clock drive microbiom maintain gastrointestin homeostasi diurnal ie hour oscil gut microbiom describ various speci includ mice human howev drive forc behind rhythm remain less clear studi differenti endogen exogen time cue drive microbi rhythm result demonstr fecal microbi oscil maintain mice kept absenc light support role host circadian system rather repres diurnal respons environment chang intestin epitheli cell specif ablat core clock gene bmal disrupt rhythmic microbiota target metabolom function link intestin clock control bacteria microbi deriv product particular branch chain fatti acid secondari bile acid microbiota transfer intestin clock defici mice germ free mice alter intestin gene express enhanc lymphoid organ weight suppress immun cell recruit result highlight import function intestin clock microbiota composit function requir balanc host gastrointestin homeostasi | D057906;D064307 | T001;T040;T032;T028 |
36,241,649 | genom basi earli life mortal sharpsnout seabream mortal earli life stage fish common natur shape stochast select process select mortal rare assess natur condit studi combin genom data inform differ life stage realat fit investig select mortal settler six month survivor sharpsnout seabream genotyp phenotypeenvironment associ studi three local along geograph gradient gather inform individu snps obtain individu base b rad librari well phenotyp environment variabl deriv individu otolith read found common signal across local potenti select lower surviv rate individu hatch earlier grow faster experienc higher temperatur plankton phase identifi loci parallel signific associ phenotyp environment variabl import one loci map exon region ilrb gene involv immun respons phylogenet closest refer genom show parallel frequenc chang non synonym mutat three studi popul tempor assess need understand polymorph key select mortal maintain | D010473;D021541 | T013 |
36,241,648 | arhgef regul stabil ac promot prolifer lung cancer rho gtpase play essenti role mani cellular process includ cell cycl progress cell motil invas migrat transform sever studi indic dysregul rho gtpase signal close relat tumorigenesi rho gef consid posit regul rho gtpase promot dissoci rho protein gdp bind gtp thus activ downstream signal pathway herein demonstr arhgef member rho gef famili play import role non small cell lung cancer nsclc found arhgef high express non small cell lung cancer facilit cancer cell prolifer nsclc cell vitro vivo studi demonstr arhgef enhanc protein homeostasi atp citrat lyas ac reduc acetyl lys lys lead dissoci ac e ligas nedd interest function arhgef protein homeostasi ac independ gef activ taken togeth find uncov novel function arhgef suggest arhgef promis therapeut target non small cell lung cancer | D002289;D008175 | T191 |
36,241,646 | tlcd tlcd regul cellular phosphatidylethanolamin composit promot progress non alcohol steatohepat fatti acid composit phosphatidylethanolamin pe determin cellular metabol oxid stress inflamm howev understand cell regul pe composit limit identifi genet locus mous chromosom contain two poor character gene tlcd tlcd strong influenc pe composit generat tlcd doubl knockout dko mice found reduc level hepat monounsatur fatti acid mufa contain pe speci mechanist tlcd protein act cell intrins promot incorpor mufa pes furthermor tlcd interact mitochondria evolutionarili conserv manner regul mitochondri pe composit last demonstr biolog relev find dietari model metabol diseas tlcd dko mice display attenu develop non alcohol steatohepat compar control overal identifi tlcd protein key regul cellular pe composit find broad implic understand treat diseas | D065626;D010714 | T047;T109;T123 |
36,241,645 | align singl cell trajectori tree capit global align complex pseudotim trajectori differ singl cell rna seq dataset challeng exist tool main focus linear align singl cell trajectori present capit compar analysi pseudotim trajectori infer tree align method compar singl cell trajectori tree align wherebi branch trajectori automat compar comput test synthet dataset authent bone marrow cell dataset indic capit achiev accur robust align trajectori tree reveal various gene express dynam includ gene gene correl conserv differ speci | D059010 | T059 |
36,241,643 | structur core human nadph oxidas nox nox prototyp member nadph oxidas nox superfamili produc superoxid key reactiv oxygen speci ros essenti innat adapt immun mutat lead defici nox activ correl increas suscept bacteri fungal infect result chronic granulomat diseas core nox form heterodimer transmembran complex compos nox former gp p detail descript structur architectur lack present structur human nox core complex bound select anti nox antibodi fragment core complex reveal intric extracellular topolog nox four transmembran fold p subunit extens transmembran interfac provid insight nox assembl activ function assay uncov inhibitori activ g antibodi mediat intern depend intern independ mechan overal result provid insight nox core complex architectur diseas caus mutat potenti avenu select nox pharmacolog modul | D019255;D013481 | T121;T109;T126;T116 |
36,241,641 | immunopeptidom base design mrna vaccin formul listeria monocytogen listeria monocytogen foodborn intracellular bacteri pathogen lead human listeriosi despit high mortal rate increas antibiot resist clinic approv vaccin listeria avail attenu listeria strain offer protect test antitumor vaccin vector would benefit better knowledg immunodomin vector antigen identifi novel antigen screen listeria peptid present surfac infect human cell line mass spectrometri base immunopeptidom human self peptid detect listeria immunopeptid differ bacteri protein includ sever known antigen peptid present differ cell line often deriv bacteri surfac protein classifi antigen potenti vaccin candid encod high present antigen lipid nanoparticl mrna vaccin formul result specif cd cell respons induc protect vaccin challeng experi mice result serv start point develop clinic mrna vaccin listeria aid improv attenu listeria vaccin vector demonstr power immunopeptidom next generat bacteri vaccin develop | D008087;D008089;D008088 | T007;T047 |
36,241,640 | water product function optim irrig schedul rice oryza sativa l cultiv drip irrig plastic film mulch studi determin water product function wpf optim irrig schedul oi rice oryza sativa l cultiv drip irrig plastic film six differ field capac level establish w w w w w result show rice growth yield qualiti signific affect differ irrig treatment rice height yield decreas wto w w highest yield lower amount irrig water appli higher irrig water use effici valu wpf model establish crop system water sensit indic calcul mathemat model show crop water sensit decreas order boot stage flower stage tiller stage fill stage base result oi determin dynam solut sever model follow optim irrig level ha tiller stage ha joint boot stage ha head flower stage ha milk stage wpf oi develop studi provid theoret basi implement rice cultiv drip irrig plastic film arid region china | D012275;D014867 | T121;T168;T002;T197 |
36,241,639 | nanoparticl base modul cd cell effector helper function enhanc adopt immunotherapi helper cd cell perform direct therapeut function augment respons cell cytotox cd cell wide varieti diseas pathogen nevertheless ineffici synthet technolog expans antigen specif cd cell hinder consist scalabl cd cell base therapi complic mechanist studi describ nanoparticl platform ex vivo cd cell cultur mimic antigen present cell apc display major histocompat class ii mhc ii molecul combin solubl co stimul signal mhc ii artifici apc aapc expand cognat murin cd cell includ rare endogen subset induc potent effector function vitro vivo moreov mhc ii aapc provid help signal enhanc antitumor function aapc activ cd cell mous tumor model last human leukocyt antigen class ii base aapc expand rare subset function antigen specif human cd cell overal mhc ii aapc provid promis approach har target cd cell respons | D016219;D053758 | T061;T073 |
36,241,638 | sewag sludg substrat schinus terebinthifolia raddi seedl commerci product schinus terebinthifolia raddi speci sever potenti use select proper substrat fertil rate vital seedl product nurseri environ studi aim evalu two substrat name sewag sludg ss ilha wwtp ii commerci substrat cs made organ materi main sphagnum peat increas rate control releas fertil crf kg appli experi complet random factori scheme substrat rate seedl growth biomass qualiti evalu treatment compar tukey test regress analysi linear quadrat cubic model consid princip compon analysi pca cluster analysi perform crf rate show non signific effect investig variabl ss substrat cs kg rate crf show best growth perform multivari analysi morpholog paramet prove suitabl complementari approach evalu seedl qualiti seedl reach recommend valu height diamet qualiti ss substrat without chemic fertil thus schinus terebinthifolia product ss ilha recommend besid growth advantag ss promot nurseri cost save commerci substrat chemic fertil | D027926;D012722 | T069;T002 |
36,241,637 | global relev stock soil nitrogen yedoma permafrost domain nitrogen regul multipl aspect permafrost climat feedback includ plant growth organ matter decomposit product potent greenhous gas nitrous oxid despit import current estim permafrost nitrogen high uncertain compil dataset sampl quantifi nitrogen stock yedoma domain region organ rich permafrost contain permafrost carbon estim yedoma domain contain gigaton nitrogen metr deepest unit increas previous estim entir permafrost zone approxim nitrogen gigaton store permafrost therefor current immobil frozen show amount store metr depth partial mobilis thaw larg nitrogen pool could continent scale consequ soil aquat biogeochemistri global scale consequ permafrost feedback | D000074382;D065946 | T167;T083;T197 |
36,241,635 | high strength damag toler echinoderm stereom natur bicontinu ceram cellular solid due low damag toler engin ceram foam often limit non structur usag work report stereom bioceram cellular solid relat densiti common found miner skelet element echinoderm eg sea urchin spine achiev simultan high relat strength approach suquet bound remark energi absorpt capabl ca kj kg uniqu bicontinu open cell foam like microstructur high strength due ultra low stress concentr within stereom load result defect free cellular morpholog near constant surfac mean curvatur negat gaussian curvatur furthermor combin bend induc microfractur branch subsequ local jam fractur fragment facilit small throat open stereom lead progress format growth damag band signific microscop densif fragment consequ contribut stereom except high damag toler | D004447;D012617 | T204 |
36,241,634 | high deforest trajectori cambodia slowli transform econom land concess restrict strateg execut redd protect area protect area pas continu establish tropic forest effort preserv biodivers reduc deforest recent demonstr pas effect reduc forest loss unprotect control site across southeast asia voluntari redd scheme offer new framework protect high deforest landscap jurisdict countri back intern carbon financ analyz econom driver deforest cambodia effect redd project vs adjac protect area find econom land concess predomin driver deforest cambodia influenc trajectori illeg forest convers pas furthermor redd project offer signific protect deforest adjac pas two three analyz case like due enhanc fund enabl implement target communiti activ rigor monitor enforc | D003247;D065928 | T064;T081;T069;T078;T070 |
36,241,632 | gut microb bacteroid fragili amelior renal fibrosi mice renal fibrosi inevit outcom various manifest progress chronic kidney diseas ckd need efficaci treatment regimen renal fibrosi therefor overemphas show novel protect role bacteroid fragili b fragili renal fibrosi mice demonstr decreas abund b fragili fece ckd patient unilater ureter obstruct uuo mice oral administr live b fragili attenu renal fibrosi uuo adenin mice model increas lipopolysaccharid lps level decreas b fragili administr result metabolom proteom studi show decreas level anhydroglucitol ag substrat sglt increas b fragili administr via enhanc renal sglt express ag agonist tgr attenu renal fibrosi inhibit oxid stress inflamm madecassosid natur product found via vitro screen promot b fragili growth remark amelior renal fibrosi find reveal amelior role b fragili renal fibrosi via decreas lps increas ag level | D001688;D000069196;D007674;D051436;D014517 | T047;T007;T121;T001;T123 |
36,241,630 | ion transfer mechan mrp type antiport high resolut cryoem molecular dynam simul multipl resist ph adapt mrp cationproton antiport essenti growth varieti halophil alkaliphil bacteria stress condit mrp type antiport close relat membran domain respiratori complex determin structur mrp antiport bacillus pseudofirmus electron cryo microscopi resolut structur resolv sidechain seven membran subunit mrpa mrpg plus water molecul includ putat ion transloc pathway molecular dynam simul base high resolut structur reveal detail antiport mechan find switch posit histidin residu three hydrat pathway mrpa subunit critic proton transfer drive gate tran membran sodium transloc sever line evid indic histidin switch mechan oper respiratori complex | D017920;D056004 | T066;T044;T123;T116 |
36,241,629 | phase trial tnf inhibitor certolizumab plus chemotherapi stage iv lung adenocarcinoma previous identifi chemotherapi induc paracrin inflammatori loop paradox mitig anti tumor effect chemotherapi trigger metastat propag breast lung cancer model therefor sought valid translat find patient care coupl anti tnf drug certolizumab pegol standard cisplatin doublet chemotherapi first valid anti metastat effect certolizumab liver metastat lewi lung carcinoma model evalu safeti efficaci pharmacodynam effect certolizumab cisplatin pemetrex open label phase clinic trial nct eighteen adult patient stage iv lung adenocarcinoma primari outcom maximum toler dose secondari outcom respons rate progress free surviv pfs pharmacodynam chang blood tumor evalu correl outcom nine partial respons among patient evalu ci median durat respons month rang month median pfs month ci nr standard mg dose certolizumab ad cisplatin pemetrex well toler correl endpoint demonstr potent pharmacodynam inhibit peripher cytokin associ paracrin inflammatori loop | D000077192;D000971;D008175 | T191;T061 |
36,241,627 | map genet architectur cortic morpholog neuroimag progress perspect cortic morpholog key determin cognit abil mental health develop high intric process span decad involv coordin local express thousand gene begin unravel genet architectur cortic morpholog thank recent avail larg scale neuroimag genom data develop power biostatist tool review progress made field provid overview lesson learn genet studi cortic volum thick surfac area fold captur neuroimag clear morpholog shape thousand genet variant effect region time depend therebi challeng convent studi approach recent genom wide associ studi start discov common genet variant influenc cortic thick surfac area yet togeth explain fraction high herit measur impact rare variant non addit effect remain elus indic quick increas avail data whole genom sequenc larg deepli phenotyp popul cohort across lifespan enabl us uncov much miss herit upcom year novel approach leverag share inform across measur acceler process provid substanti increas statist power togeth accur map genet relationship import challeng remain includ better represent understudi demograph group integr omic data map effect gene brain behavior across lifespan | D055106;D059906 | T060;T063 |
36,241,625 | oppos function circadian protein dbp atyp ef famili ef anti tumor th cell differenti interleukin il produc cd helper cell th implic allergyasthma anti tumor immun yet molecular insight differenti activ cell driven il transform growth factor beta tgf still lack show oppos function two transcript factor bind protein dbp ef control th differenti specif tgf il signal induc phosphoryl serin site linker region smad psmadl ser via phosphoryl p necessari suffici il gene transcript identifi dbp ef activ repressor respect il transcript psmadl ser notabl th cell sirna mediat knockdown dbp ef promot suppress tumor growth respect mous tumor model import dbp ef also exhibit oppos function regul human th differenti vitro thus data uncov molecular mechan smad linker region mediat oppos function dbp ef th differenti | D015847;D016906 | T121;T116;T129 |
36,241,624 | dna methyl birth monozygot twin discord pediatr acut lymphoblast leukemia aberr dna methyl constitut key featur pediatr acut lymphoblast leukemia diagnosi howev role predispos earli contributor leukemia develop remain unknown evalu dna methyl birth leukemia discord monozygot twin pair use illumina epic array archiv neonat blood spot identifi epigenet variat associ develop pediatr acut lymphoblast leukemia independ genet influenc condit logist regress identifi signific probe region associ discord onset leukemia identifi signific negat coeffici bias indic dna hypomethyl case across array enhanc open sea shelfshor gene bodi region compar promot cpg island region show associ global dna hypomethyl futur develop pediatr acut lymphoblast leukemia across diseas discord genet ident twin impli dna hypomethyl may contribut general leukemia risk | D054198;D014430 | T191;T099 |
36,241,621 | spinal cord stimul medullari compress rare scs complic surgic treatment risk spinal cord damag spinal cord stimul scs implant rare event case report patient affect progress worsen spinal stenosi due scs compress | D020918;D055111;D013117;D062187;D013130 | T061;T047;T020 |
36,241,620 | hemipiperazin peptid deriv molecular photoswitch low nanomolar cytotox molecular photoswitch transform light energi revers structur chang combin known pharmacophor often allow photomodul biolog activ effort appli compound photopharmacolog light activ pro drug howev hamper serious activ reduct upon pharmacophor modif limit biostabl report potent antimitot agent plinabulin deriv demonstr fold revers activ photomodul altern irrevers photoactiv cyan light enhanc cytotox three order magnitud without compromis origin activ level origin pharmacophor structur unchang occur due presenc peptid deriv photoswitch motif hemipiperazin insid plinabulin scaffold furthermor systemat describ photochrom thermal stabl biocompat hemipiperazin well photoswitch fluorophor deriv plinabulin latter may expand applic hemipiperazin photochrom toward super resolut microscopi | D050256;D011355 | T121;T120 |
36,241,617 | fibrocyt boost tumor support phenotyp switch lung cancer nich via endothelin system fibrocyt bone marrow deriv monocyt cell implic wound heal identifi role lung cancer progress metastasi select manipul fibrocyt mous lung tumor model document central role fibrocyt boost nich featur enhanc metastasi import lung cancer patient show increas number circul fibrocyt mark fibrocyt accumul cancer nich use doubl tripl co cultur system human lung cancer cell fibrocyt macrophag endotheli cell substanti central featur cancer support nich enhanc cancer cell prolifer migrat macrophag activ augment endotheli cell sprout fibrocyt matur upregul endothelin receptor note dual endothelin receptor blockad suppress cancer support phenotyp alter via act fibrocyt interact cancer nich thus provid evid crucial role fibrocyt lung cancer progress metastasi suggest target treatment strategi | D042783;D008175 | T191;T025 |
36,241,614 | induct hepat aryl hydrocarbon receptor alcohol dysregul autophagi phospholipid metabol via ppprd disturb lipid metabol preced alcohol liver injuri whether ahr alter degrad lipid particular phospho sphingo lipid alcohol exposur explor show alcohol consumpt mice result induct activ aryl hydrocarbon receptor ahr liver chang hepat phospho sphingo lipid content level kynurenin endogen ahr ligand elev increas hepat tryptophan metabol enzym alcohol fed mice either alcohol kynurenin treatment promot ahr activ autophagi dysregul via ampk protein phosphatas regulatori subunit bdelta ppprd identifi transcript target ahr consequ ppprd depend ampk dephosphoryl caus autophagi inhibit mitochondri dysfunct hepatocyt specif ahr ablat attenu steatosi associ recoveri phospho sphingo lipid content chang ahr target corrobor use patient specimen overal ahr induct alcohol inhibit autophagi hepatocyt ampk mediat ppprd gene transactiv reveal ahr depend metabol phospho sphingo lipid | D055372;D018336 | T126;T116;T192 |
36,241,613 | fab region igg impair intern pathway fcrn upon fc engag bind neonat fc receptor fcrn extend serum half life igg antagon interact promis therapeut approach igg mediat autoimmun diseas fc mst hn design enhanc fcrn bind capac evalu context full length antibodi structur properti attach fab region might affect fcrn mediat intracellular traffick pathway present comprehens compar analysi igg salvag pathway two full size igg variant contain wild type mst hn fc fragment fc counterpart find evid fab region affect fcrn bind cell free assay howev cellular assay show impair bind full size igg fcrn translat improv intracellular fcrn occup intracellular accumul fc mst hn compar full size igg mst hn crystal structur fc mst hn complex fcrn provid plausibl explan fab disrupt interact context membran associ fcrn import find fc mst hn outperform full size igg mst hn reduc igg level cynomolgus monkey collect find identifi cellular membran context critic factor fcrn biolog therapeut target | D000911;D001327 | T047;T116;T129 |
36,241,608 | clmp promot leukocyt migrat across brain barrier multipl sclerosi multipl sclerosi ms peripher immun cell use various cell traffick molecul infiltr cns caus damageth object studi investig involv coxsacki adenovirus receptor like membran protein clmp migrat immun cell cns patient ms | D009103 | T047 |
36,241,590 | feasibl preliminari efficaci earli time restrict eat diet qualiti colleg student random studi meal time import consider assess health primari outcom pilot studi examin feasibl preliminari efficaci earli time restrict eat etr diet qualiti sampl colleg student attend larg southwestern univers cardiometabol indic anthropometr measur also obtain studi plan eight week intervent howev covid necessit laboratori closur disrupt data collect week eight henc data obtain week zero baselin week four viabl analysi present herein twenti five healthi particip random intervent group etr consist daili hour eat window control group con consist daili hour eat window week particip permit one day respect studi protocol seventeen particip complet aspect studi diet qualiti data obtain one addit particip n preliminari find indic hour etr protocol may benefici weight reduct reduc energi dens food typic consum even hour later night futur research accommod individu prefer regard initi time eat window also provid evid base nutrit recommend improv diet qualiti | D005247;D000086382 | T067;T055;T047;T040 |
36,241,563 | attent bias modif transcrani direct current stimul tdcs review attent bias tendenc prefer detect orient select emot valu stimuli compar neutral stimuli play crucial role psychopatholog various psychiatr disord transcrani direct current stimul tdcs appli alter attent bias health diseas differ paramet condit contribut factor magnitud direct effect previous comprehens review review aim systemat explor effect tdcs attent bias differ task tdcs condit health state data collect accord prisma approach literatur search identifi origin experi explor effect tdcs attent bias determin tdcs effect attent bias cortic target area specif task studi stimul paramet presenc psychopatholog relev cortic area modif attent bias via tdcs dorsolater prefront cortex dlpfc ventromedi prefront cortex vmpfc observ heterogen impact tdcs modul attent bias explain area stimul valenc stimuli task characterist intens stimul | D065908 | T061 |
36,241,548 | effect occup incid vascular dementia year follow cohort studi vascular dementia dv second caus dementia case previous studi effect occup dv show conclus result therefor object analyz type occup vari risk develop dv older year | D015140 | T047 |
36,241,544 | character nasopharyng microbiom patient kawasaki diseas aetiolog kawasaki diseas kd remain unknown sever studi link human microbiom diseas howev limit studi role respiratori microbiom kd aim studi make thorough analysi caus process increas suscept kd | D009080;D064307 | T001;T047;T032;T028 |
36,241,532 | dysfunct trna reprogram codon bias translat cancer mani cancer hijack translat increas synthesi tumor drive protein messeng mrnas specif codon usag pattern term codon bias translat origin identifi stress respons regul mechan support divers studi demonstr rna modif epitranscriptom specif trnas codon bias mrnas use oncogen program promot prolifer chemoresist epitranscriptom writer mettl wdr elong complex protein elp ctu alkbh trm illustr princip mechan codon bias translat gene amplif increas rna modif enhanc trna stabil promot cancer prolifer furthermor system level analys trna writer trna gene highlight theme trna epitranscriptom dysregul mani cancer identifi candid trna writer trna modif trna molecul driver patholog codon bias translat | D000081183;D009369 | T191;T045 |
36,241,525 | incid preval treatment pattern metastat hormon sensit prostat cancer spain echo studi manag patient metastat hormon sensit prostat cancer mhspc chang recent year due approv new drug aim studi evalu preval incid treatment pattern mhspc spain | D000726;D011471 | T121;T039;T191 |
36,241,517 | brain death due neuroaspergillosi patient covid co infect sar cov pathogen import consider treatment patient covid aspergillus infect part consider sinc present high morbid mortal present case patient covid aspergillus fumigatus coinfect evolv brain death due multipl heterogen lesion brain post mortem biopsi found patholog lesion compat aspergillus | D020953;D000086382 | T047;T067 |
36,241,515 | pitfal cubit electr nerv stimul neuromuscular transmiss monitor case report famili amyloid polyneuropathi transthyretin famili amyloid polyneuropathi fap rare autosom domin diseas provok system deposit amyloid affect nervous system character progress sensori motor autonom neuropathi patient fap often requir surgeri anesthet care hepat transplant cardiovert defibrillatorpacemak implant peripher neuropathi common find report case interfer anesthet neuromuscular transmiss monitor report case fap patient lack awar distract factor led misinterpret neuromuscular monitor unnecessari sedat ventil post anesthet care unit fap may interfer usual cubit nerv neuromuscular monitor anesthesiologist awar potenti neuromuscular compromis find best monitor locat patient sugammadex safe reliabl antagon rocuronium neuromuscular blockad case despit lack adequ quantit monitor | D028227;D016031 | T061;T047 |
36,241,512 | inter rater reliabl measur diaphragmat excurs fraction diaphragmat thicken ultrasonographi healthi volunt determin inter rater reliabl ultrasonograph us measur diaphragmat excurs de diaphragm thick fraction dtf perform non medic health profession healthi peopl | D003964;D045853 | T023;T040 |
36,241,511 | clinic trial determin whether time tranexam acid administr influenc periop bleed total knee arthroplasti ideal time tranexam acid administr total knee arthroplasti tourniquet remain unclear primari object prove administ surgic incis instead releas tourniquet reduc postop bleed second object determin whether second dose reduc post oper bleed | D014148;D019645;D000933;D000072836 | T121;T061;T109;T037 |
36,241,508 | peripher va ecmo left ventricular dysfunct combin biventricular assist two case report report patient cardiogen shock develop sever left ventricular dysfunct due non open aortic valv peripher va ecmo veno arteri extracorpor membran oxygen patient manag combin lv left ventricl mechan assist devic central va ecmo support right ventricl thus provid full circulatori respiratori assist patient abl bridg cardiac transplant therefor recommend combin patient sever lv dysfunct p ecmo peripher ecmo support | D015199;D018487 | T061;T046 |
36,241,504 | breast reconstruct use latissimus dorsi flap immedi fat transfer lift systemat review meta analysi despit sever effort made increas volum latissimus dorsi ld flap studi report outcom ld flap immedi fat transfer lift restor natur nativ breast appear initi reconstruct procedur aim studi report differ surgic techniqu use implement lift breast reconstruct evalu postop outcom | D064171;D016462;D058752;D001943 | T191;T061;T023;T024 |
36,241,499 | effect elev co cd uptak rice cd contamin paddi soil rise atmospher co major driver climat chang direct affect rice product cadmium cd paddi soil also serv persist concern current studi consid rice respons coupl stress elev co eco soil cd experiment evid understand effect mechan eco cd uptak rice lack yet free air co enrich face system year pot experi conduct explor cd uptak rice two co condit ambient ambient molmol use combin situ cd contamin soil associ rice varieti result show low crystallin fe oxid feh iron plaqu ip deposit root surfac increas dissolv fe due lower soil redox status eco cd accumul rice hinder due cd associ feh feh cd rather uptak root taken togeth relat effect eco cd uptak rice consist across year differ cd contamin soil find help better understand cd uptak rice futur climat condit thus push develop climat crop soil model accur predict food secur | D012275;D012989 | T131;T168;T002 |
36,241,426 | direct cd cell cytotox implic breast cancer prognosi treatment fcrii cd ligand igfc fragment pentraxin exist addit ligand unknown engin cell human chimer receptor result fusion cd extracellular portion transmembran cd link cd chain intracellular moieti cd cr transduc cell recogn three breast cancer bc one colon cancer cell line among test absenc target antibodi sensit bc cell conjug cd cr cell induc cd polar regul cda releas mutual elimin proinflammatori cytokin product unaffect human igg enhanc cetuximab cd cr cell protect immunodefici mice subcutan growth mda mb bc cell rnaseq analysi identifi gene fingerprint predict bc cell sensit favor outcom advanc bc icam major regul cd cr cell mediat cytotox cd cr cell may help identifi cell surfac cd ligand novel prognost relev transcriptom signatur develop innov bc treatment | D001943;D013601 | T191;T025 |
36,241,425 | low express exosc protect clinic covid imped sar cov replic new therapeut target valuabl resourc treatment sar cov viral infect genom wide associ studi identifi risk loci associ covid mani loci associ comorbid specif host virus interact identifi experiment valid link reduc express exosc reduc sar cov replic exosc one host protein examin interact direct sar cov protein aggreg covid genom wide associ studi statist gene specif eqtl reveal associ increas express exosc higher risk clinic covid exosc interact nsp form part viral rna polymeras exosc compon rna exosom lc msms analysi protein pulldown demonstr interact sar cov rna polymeras human rna exosom compon crisprca introduct nonsens mutat within exosc calu cell reduc exosc protein express imped sar cov replic without impact cellular viabil target deplet exosc may safe effect strategi protect clinic covid | D000086382;D000086402 | T047;T067;T005 |
36,241,421 | prefront cortic mediodors thalamus project neuron regul posterror adapt control behavior adapt control onlin adjust behavior guid optim respons error conflict neural circuit involv monitor adapt behavior perform follow error poor understood prefront cortex pfc play critic role form control howev brain area dens connect mani region unknown project critic adapt behavior test involv four distinct dorsal ventral prefront cortic project striatal thalam target area adapt control analyz data publish experi use trial trial analys behavior oper task attent impuls find male rat slow respons perform wors follow error moreov combin retrograd label chemogenet silenc find dorsomedi prefront pyramid neuron project later nucleus mediodors thalamus mdl involv posterror perform time respons specif unpredict delay stimulus present togeth data show dorsal medial pfc mpfc project neuron target later mdt regul adapt control flexibl optim behavior respons goal direct behavior | D017397;D013788 | T023;T030;T029 |
36,241,420 | develop open face home cage run wheel test activ base anorexia applic run wheel mice resid home cage use continu measur locomotor activ studi test exercis intervent exercis induc effect brain metabol develop open sourc printabl open face run wheel autom collect locomotor inform distanc travel wheel direct veloc bin epoch h multipl day system allow remot data collect avoid human interfer mous behavior experi test system activ base anorexia procedur use wheel replic previous find food restrict augment wheel run activ | D000855;D009043 | T056;T047 |
36,241,414 | youth clinic model youth sexual health promis solut ensur access care understand servic offer youth clinic site special youth sexual health servic implic model young peopl well | D000074384 | T032 |
36,241,406 | comprehens care women depress associ primari care use cervic cancer screen explor comprehens care patient depress examin associ diagnosi depress frequenc primari care visit papanicolaou test complet | D002583 | T191 |
36,241,402 | languag outcom cochlear implant young infant seen practic diagnos profound congenit hear loss parent want pursu cochlear implant surgeri child concern languag acquisit surgeri know procedur improv languag outcom | D019929;D003054;D003638;D006310 | T047;T061;T074;T184;T033 |
36,241,360 | rapid separ identif main constitu huanglian jiedu decoct via ultra high perform liquid chromatographi orbitrap fusion tribrid mass spectromet huanglian jiedu decoct wide use tradit chines medicin broad spectrum therapeut effect includ heat clear detoxif attenu inflamm howev composit huanglian jiedu decoct still unclear due complex limit analyt method studi establish fast reliabl analyt method base ultra perform lc orbitrap fusion tribrid mass spectromet high speed separ structur identif multipl compound huanglian jiedu decoct analysi carri use hypersil gold c column mm gradient elut coupl high definit mass spectromet system oper posit negat esi mode accord chromatograph retent time precis molecular weight fragment ion peak publish data main chromatograph peak attribut specif molecul whose chemic structur determin total compon identifi includ flavonoid glycosid alkaloid organ acid terpenoid miscellan compound studi reveal detail chemic composit huanglian jiedu decoct great import qualiti control pharmacolog mechanist studi | D004365 | T121;T123 |
36,241,359 | measur psycholog safeti local learn enabl high reliabl organis chang abil measur extent organis high reliabl extent reliabl may chang time kept develop theori paper examin aspect workplac cultur employe motiv leadership behaviour support continu learn improv effort measur transit high reliabilityto evalu effect high reliabl initi one children hospit sought build measur would provid assess progress movement toward cultur safeti track success time paper report develop two scale trust team member trust leadership intend measur two cultur condit foster five high reliabl principl composit measur local learn activ two scale strong associ local learn activ employe work area employe willing particip extra role activ suggest foundat creat psycholog safe environ thus becom high reliabl organis | D000085264;D007857 | T054;T092;T078 |
36,241,357 | present extraordinari colic abdomin pain first utter acquir c inhibitor defici c inhibitor defici rare diseas incorpor acut self limit intermitt swell subcutan tissu mucous membran attack frequent affect face andor upper airway isol angioedema small bowel uncommon manifest often accompani diagnost delay present case abdomin pain turn first utter acquir c inhibitor defici secondari splenic margin zone lymphoma imag show wall thicken small intestin ascit splenomegali abdomin pain intestin wall thicken surround ascit imag spontan resolv episod within day gastrointestin manifest angioedema may mimic acut abdomen subsequ one third patient undergo unnecessari surgeri prior definit diagnosi emphasis import consid diagnosi case extraordinari colic | D000799;D054179;D003085 | T047;T046;T184;T033 |
36,241,356 | prefer peopl mild cognit impair physic activ intervent china protocol discret choic experi studi exercis intervent import non pharmacolog intervent patient mild cognit impair mci patient mci poor complianc consist strategi exercis intervent understand need prefer mci patient allow develop effect accept exercis intervent programm achiev goal patient centr care studi use discret choic experi dce measur quantifi mci patient prefer exercis intervent aim identifi explor element exercis intervent programm essenti mci patient measur mci patient prefer exercis intervent summaris relev characterist may influenc prefer choic determin whether prefer vari particip characterist classifi popul type base sociodemograph characterist particip | D060825;D057240 | T048;T080 |
36,241,355 | cardiovascular renal efficaci safeti sodium glucos cotransport inhibitor patient without diabet systemat review meta analysi randomis placebo control trial assess cardiovascular renal efficaci safeti sodium glucos cotransport sglt inhibitor patient without diabet | D002318;D003924;D006333;D051436;D000077203 | T121;T047;T046;T109 |
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