PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,241,239 | year retrospect analysi spectrum treatment option orthostat intoler sit intoler children analyz diseas spectrum under orthostat intoler oi sit intoler si chines children understand clinic empir treatment option | D008879;D054971;D054972;D019462 | T121;T047;T109;T033 |
36,241,238 | clinic characterist prognosi seizur children acut lymphoblast leukemia investig clinic characterist treatment prognosi seizur children acut lymphoblast leukemia chemotherapi | D001927;D004827;D054198 | T191;T047;T033 |
36,241,237 | clinic effect fetal reduct intracrani intrathorac kcl inject evalu feasibl effect fetal reduct transabdomin intracrani kcl inject multifet pregnanc earli second trimest | D002585;D018607 | T061;T079 |
36,241,236 | clinic analysi fertil spare therapi patient complex atyp hyperplasia endometri cancer analyz efficaci prognosi fertil spare therapi patient complex atyp hyperplasia cah endometri cancer ec | D004714;D016889;D059247 | T191;T061;T047 |
36,241,235 | heal dento gingiv junction follow modifi crown lengthen procedur beagl dog evalu type wound heal follow modifi crown lengthen surgeri dog model provid biolog basi clinic applic | D016556;D004846 | T061;T024 |
36,241,234 | natur histori diseas progress chronic hepat b virus infect better understand revis natur histori diseas progress chronic hepat b virus hbv infect analysi singl center larg scale cohort indivi dual chronic hbv infect | D019694 | T047 |
36,241,233 | bioactiv compound jingfang granul sar cov virus proteas cl pro pl pro jingfang granul recommend prevent treatment corona virus diseas covid chemic analysi bioactiv evalu studi aim elucid potenti effect compon jingfang granul | D000996;D000086382 | T121;T047;T067 |
36,241,232 | naringenin inhibit thorac aortic aneurysm format mice marfan syndrom identifi whether naringenin play protect role thorac aneurysm format marfan syndrom | D017545;D008382 | T047 |
36,241,231 | preclin studi cell receptor specif reactiv kras gv mutat treatment malign tumor kras gene one common mutat proto oncogen human tumor gv one common mutat type kras challeng chemic acquir target drug mutat recent studi report mutat peptid form neoepitop cell recognit studi aim clone cell receptor tcr specif recogn neoepitop kras gv mutat construct tcr engin cell tcr investig tcr ts strong antitumor respons abil | D009369;D016283 | T191;T126;T116 |
36,241,230 | genet distribut chines patient hereditari peripher neuropathi analyz distribut characterist hereditari peripher neuropathi hpn pathogen gene chines han popul explor potenti pathogenesi treatment prospect hpn relat diseas | D000690;D002607;D009134 | T047 |
36,241,229 | variat fecal microbiota first episod schizophrenia associ clinic assess serum metabolom explor role microbiota drug nave first onset schizophrenia patient seek evid multidimension longitudin analys intestin microbiom clinic phenotyp antipsychot drug apd therapi | D014150;D064307;D012559;D005243 | T028;T121;T001;T039;T048;T031;T032 |
36,241,228 | clinicopatholog featur prognosi hormon receptor positivehuman epiderm growth factor receptor negat breast cancer investig clinicopatholog featur prognosi hormon receptor posit hr human epiderm growth factor receptor negat breast cancer | D001943;D064726 | T191 |
36,241,227 | kindlin regul endometrium develop via mtor hippo signal pathway mice investig effect mechan kindlin uterus develop reproduct capac femal mice | D055372;D000090683 | T043;T126;T116 |
36,241,226 | establish applic new techniqu submandibular gland preserv saliva secret submandibular gland smg account play import role maintain human function swallow digest test speech protect oral mucosa prevent dental carri smg frequent resect treatment various kind oral maxillofaci diseas result xerostomia decreas qualiti life past year research center salivari gland diseas peke univers school hospit stomatolog conduct seri studi new techniqu preserv smg achiev remark result clinicopatholog imag characterist igg relat sialaden igg rs clarifi base systemat studi result studi pathogenesi igg rs show unbal inflammatori factor mediat abnorm secret smg il particip occur develop glandular fibrosi smg regul tumor necrosi factor tnf clean senesc cell might taken target treatment igg rs combin glucocorticoid steroid spare agent show effect result treat igg rs clinic remiss achiev patient serum igg level decreas salivari gland secret signific increas sialoendoscopi assist sialolithectomi appli treatment case submandibular hilar calculi success rate transfer smg use prevent radiat induc xerostomia patient head neck carcinoma smg transfer subment region radiotherapi kept away ra diation field result prospect clinic control studi show techniqu could effect preserv function smg prevent xerostomia base micro anatom studi blood vessel duct smg partial sialoadenectomi appli treatment benign tumor smg clinic control studi confirm safeti control tumor advantag preserv smg function studi involv smg oral squamous cell carcinoma oscc provid anatom histopatholog basi preserv smg neck dissect earli case oscc innov surgic modal four preserv includ smg use neck dissect earli case oscc prospect random clinic control studi confirm safeti feasibl effect control carcinoma advantag preserv smg function | D002294;D009062;D012793;D014987 | T191;T047 |
36,241,174 | chemic kinet mass action coexist phase kinet chemic reaction determin law mass action success appli homogen dilut mixtur nondilut condit interact among compon give rise coexist phase signific alter kinet chemic reaction deriv theori chemic reaction coexist phase phase equilibrium show phase equilibrium coupl rate chemic reaction compon diffus exchang phase strike chemic relax kinet repres flow along phase equilibrium line phase diagram key find theori differ reaction rate coexist phase stem sole phase depend reaction rate coeffici theori key interpret concentr level reactiv compon condens phase control chemic reaction rate synthet biolog system | D007700 | T070 |
36,241,173 | alad inhibit porphobilinogen ration accumul aminolevulin acut porphyria patient major form acut hepat porphyria present acut neurolog attack overproduct porphobilinogen pbg aminolevulin acid ala even ala consid like agent induc acut symptom mechan accumul experiment demonstr frequent form acut intermitt porphyria aip inherit gene mutat induc defici pbg deaminas thus accumul substrat pbg biochem oblig ala similar scenario observ form acut hepat porphyria ie porphyria varieg vp pbg deaminas inhibit metabol intermedi investig molecular basi aminolevulin accumul use vitro fluxom monitor nmr spectroscopi biophys techniqu result show porphobilinogen natur product aminolevulin deaminas effect inhibit anabol enzym abnorm low concentr structur high affin explain interact porphobilinogen generat activ site share substrat enzymat flux analysi alter heme pathway demonstr minimum accumul porphobilinogen immedi trigger accumul aminolevulin long last observ patient suffer acut porphyria | D017118;D017094 | T047 |
36,241,172 | onset chiral plasmon meta molecul dielectr coupl chiral fundament featur domain natur rang particl physic electromagnet chemistri biolog chiral object lack mirror plane invers symmetri therefor spatial align mirror counterpart enantiom natur molecul artifici chiral nanostructur character light matter interact reflect circular dichroism cd use dna origami assembl model meta molecul multipl plasmon nanoparticl repres meta atom accur posit space allow us reconstruct piec piec impact vari macromolecular geometri surround optic near field next emerg cd signatur instanc architect third dimens design implement sign flip signal addit remov singl particl artifici molecul data theoret model reveal hitherto unrecogn phenomenon chiral plasmon dielectr coupl explain intric electromagnet interact within hybrid dna base plasmon nanostructur | D006046;D049329 | T121;T196;T073 |
36,241,171 | toxicokinet model transfer non dioxin like polychlorin biphenyl ndl pcbs feed soil lay hen egg non dioxin like polychlorin biphenyl ndl pcbs subclass persist bioaccumul pollut abl enter food chain toxicokinet model transfer six ndl pcb congen pcbs contamin feed soil chicken egg meat present three independ control feed studi dataset use estim model paramet four studi evalu model perform yolk deposit ndl pcbs model novel way mimic physiolog yolk growth develop result improv predict experiment data without introduc ad hoc time delay ovul oviposit use model highest level gkg dri matter dm calcul sum ndl pcbs lay hen feed ensur current maximum level meat egg ngg fat exceed also shown highest level feed adapt case soil addit feed also sourc ndl pcbs free rang chicken | D011078;D004147;D000072317;D004785 | T121;T109;T131 |
36,241,168 | immunogen efficaci covid vaccin peopl live hiv systemat review meta analysi avail data show covid vaccin may less effect peopl live hiv plwh increas risk sever covid meta analysi aim compar immunogen efficaci covid vaccin plwh healthi individu | D000086382;D015658 | T047;T067 |
36,241,167 | evolutionari phylogeographi reveal novel genotyp coxsackievirus variant updat spatiotempor dynam popul acut hemorrhag conjunct coxsackievirus variant cvav rais remark concern main etiolog role acut hemorrhag conjunct | D003232;D030015;D003384 | T047;T005 |
36,241,166 | effect covid target nonpharmaceut intervent children respiratori admiss china nation multicent time seri studi estim impact nonpharmaceut intervent npis target covid pandem admiss number respiratori diseas includ pneumonia acut bronchiti bronchiol acut upper respiratori infect auri children china | D000086382;D001988;D011014;D001991 | T050;T047;T067 |
36,241,164 | staphylococcus aureus caus primari foot botryomycosi mimick actinomycetoma case report sudan botryomycosi rare chronic granulomat inflammatori diseas bacteri origin two form diseas exist cutan viscer form subcutan form mimic actinomycetoma clinic histolog howev treatment differ communic report sudanes male patient present foot botryomycosi | D008271;D013203 | T047 |
36,241,129 | diagnost valu f facbc petmri brain metastas studi aim evalu whether combin f facbc petmri could provid addit diagnost inform compar mri alon brain metastas | D001932;D003503 | T191;T109 |
36,241,123 | solar driven semi conductor photocatalyt water treatment tio g c n tio g c n cyanotoxin proof concept studi microcystin lr cyanobacteria toxin threat drink water safeti increas cyanobacteri bloom mass occurr occur lake reservoir world photocatalyt remov cyanotoxin solar light activ catalyst promis way purifi water relat low cost compar modifi exist infrastructur establish facil low cost method obtain tio g c n coat float photocatalyst use recycl glass bead g c n coat tio g c n co coat bead abl complet remov microcystin lr artifici fresh water natur simul solar light irradi without agit less h tio coat bead achiev complet remov within h irradi tio g c n bead effect g c n bead demonstr increas reaction rate reaction constant min compar min respect tio alon found consider slower min g c n base photocatalyst show similar degrad pathway tio base photocatalyst attack c c doubl bond adda side chain | D018508;D000458 | T007;T057;T052 |
36,241,122 | spatiotempor life histori relat trend per polyfluoroalkyl substanc indo pacif finless porpois south china sea per polyfluoroalkyl substanc pfass level indo pacif finless porpois neophocaena phocaenoid pearl river estuari pre near econom develop region china character measur hepat concentr twelv pfass includ nine perfluoroalkyl carboxyl acid pfcas three perfluoroalkan sulfon acid pfsas finless porpois n collect pre averag level pfsas time higher pfcas order six domin pfass perfluorooctan sulfon pfos perfluoroundecano acid pfuda perfluorodecano acid pfda perfluorotridecano acid pftrda perfluorononano acid pfna perfluorododecano acid pfdoda level hepat pfos sampl exceed observ advers effect level noael valu concentr pfass male signific higher femal pfass level signific negat correl bodi length male posit correl femal pfass level pre finless porpois lower humpback dolphin possibl due differ forag habitat toward coast consumpt less fish pfcas level finless porpois western pre higher compar hong kong possibl due high intens sourc terrestri anthropogen pollut signific increas spatiotempor trend pfsas pfcas pfass found finless porpois suggest continu increas risk pfass exposur pre cetacean last decad | D005466;D019576;D017738;D004289;D014874 | T015;T109;T131 |
36,241,121 | subcellular distribut physiolog respons nativ exot grass pampa biom subject excess manganes fungicid contain manganes mn appli control plant diseas increas concentr mn soil may potenti mn toxic acid soil speci wild grass pampa biom locat south america even introduc biom may possess differ mechan toler excess mn present studi aim evalu subcellular distribut physiolog biochem respons exot nativ grass pampa biom cultiv mn excess experi conduct nutrient solut greenhous entir random design bifactori consist four mn concentr control four speci two exot avena strigosa lolium multiflorum two nativ paspalum notatum paspalum plicatulum day exposur treatment biomass growth rate leaf gas exchang environ photosynthet pigment concentr malondialdehyd h antioxid enzym activ sod pod subcellular distribut mn evalu grass show high concentr mn tissu main shoot presenc mn absorb mn compartment cell wall vacuol cell compartment mn excess metabol less activ organell main toler factor grass physiolog biochem respons stimul presenc mn mn negat affect biochem physiolog respons grass speci l multiflorum sensit excess mn p notatum toler | D008345;D006109 | T123;T002;T196 |
36,241,119 | swim pfas public privat pool per polyfluoroalkyl substanc pfas class anthropogen chemic use provid water stain resist mani consum product widespread use near ubiquit presenc across multipl environ grow list advers health effect rais concern among communiti pfas frequent detect quantifi global wastewat groundwat surfac drink water howev presenc pfas swim pool water uniqu matrix constitu may concentr evapor also may present high risk direct human exposur report ultra high perform liquid chromatographi tandem mass spectrometri uhplc msms use monitor pfas water sampl collect citi apart hotel person swim pool six florida citi total pfas detect six perfluoroalkyl acid perfluorobutano acid pfba perfluorohexano acid pfhxa perfluoroheptano acid pfhpa perfluorooctano acid pfoa perfluorononano acid pfna perfluorobutan sulfon pfbs detect everi sampl pfhxa account pfas quantifi studi pfas profil compar site function pool type rate use geograph locat total pfas concentr similar across pool type highest ngl lowest ngl measur found public citi pool site higher pfas level observ citi pool miami melbourn tampa compar napl orlando gainesvill find highlight potenti exposur pfas underexplor yet import exposur pathway communiti | D005466;D014874;D060766;D017738 | T109;T131;T167 |
36,241,118 | high effici decomposit method mono dimethylmercuri induc low energi electron attach ev comput insight decomposit mechan extrem toxic mercuri compound dimethylmercuri dmm monomethylmercuri mmm extrem toxic danger environment contamin unfortun effect way remov substanc environ studi look effici decomposit dmm mmm low energi electron calcul quantum scatter properti reveal presenc metast electron state molecul examin spatial featur electron reson well comput character vibrat normal mode suggest possibl bond break pathway metast electron state electron reson result releas hg easili transport gas phase due low solubl water high volatil | D008767;D008628;D017669 | T109;T131;T197;T196 |
36,241,117 | effect sulfid nitrobenzen remov groundwat microscal zero valent iron insight reactiv reaction site remov pathway recogn sulfid effect improv reactiv microscal zero valent iron mzvi limit understand nitrobenzen arno remov sulfid mzvi understand reduct capac pathway arno sulfid mzvi ball mill sulfid mzvi mzvi bm differ sfe molar ratio use conduct experi result show sulfid could effici enhanc arno remov iron limit iron excess condit attribut presenc fes x site could provid higher fe util effici stronger passiv resist mzvi bm optimum arno reduct could obtain mzvi bm sfe molar ratio could complet transform arno anilin arnh rate constant min min reaction fes x phase could act electron transfer site arno reduct could still reserv mzvi bm reduct reaction product distribut indic sulfid chang type reduct product remov arno mzvi bm step step reduct progress along adsorpt arnh addit faster reduct arno groundwatersoil system demonstr feasibl mzvi bm real field remedi | D014874;D060587 | T082;T131;T081;T070 |
36,241,116 | recycl magnet fe c methylen blue remov microwav induc reaction system reclam remov organ pollut difficult issu world concern studi microwav induc reaction system mir appli synthes multifunct composit fe c employ adsorb separ catalyt oxid typic organ dye methylen blue mb sem tem vsm xps phpzc n adsorpt perform carri character fe c result show fe c main consist activ fe c microspher possess plenti mesopor macropor structur surfac batch adsorpt experi carri vari key reaction condit optim maximum adsorpt capac mb onto fe c mg g min ph temperatur k mir also assist regener spent fe c present good regener effici sustain regener cycl without oxid agent sem imag ftir spectrum verifi mb would translat greater smaller size carbon microspher adsorpt mb onto initi th regener fe c obey langmuir isotherm model follow pseudo second order adsorpt kinet indic adsorpt stabil regener studi fe c combin mir may one innov strategi organ pollut complet remov futur | D004785;D014874 | T131 |
36,241,115 | speciat analysi format mechan iron phosphorus compound chemic phosphorus remov process iron fe salt appli extens remov phosphorus p wastewat treatment plant wwtps explor format mechan iron phosphorus compound fep chemic p remov cpr process benefici p recoveri studi perform p remov fep speciat analysi kinet p remov differ condit ph fep molar ratio fep mol type fe salt dissolv organ matter comprehens investig p remov optim condit ph fep mol fecl polymer ferric sulfat pfs coagul fep format mechan consider influenc reaction condit iron phosphat compound domin fep speci ph iron oxid form ph decreas p remov effici initi fep mol iron phosphat compound product form reaction po fe iii fe ii ion direct iron oxid generat initi fep mol fep mol fe iii hydrolyz form iron oxid trap po fep mol iron phosphat compound produc first remain fe iii hydrolyz form iron oxid pseudo second order kinet model simul chemic p remov process well reaction rate p fe ii slower fe iii complet remov still achiev reaction time min poli fe salt exhibit fast p remov rate remov effici depend iron content organ matter wastewat larg molecular weight multipl function group humic acid inhibit p remov rate hard affect remov amount studi provid insight cpr fe salt benefici p recoveri wwtps | D005290;D058085 | T104 |
36,241,113 | acceler transform sodium dodecylbenzen sulfon surfact uvchlorin process kinet format chlorin disinfect product degrad kinet sodium dodecylbenzen sulfon sdbs surfact uvchlorin process comprehens investig format chlorin disinfect product cl dbps determin result show degrad sdbs uv chlorin uvchlorin follow pseudo first order kinet rate constant uvchlorin ultrapur water approxim time higher sum uv chlorin decreas min ph increas water matric hco natur organ matter nom inhibit degrad effici certain extent second order rate constant sdbs ho determin use differ probe main contributor sdbs degrad found uv ho reactiv chlorin speci rcs meanwhil g l trichloromethan tcm g l chloral hydrat ch simultan form within min uvchlorin treatment concentr total organ chlorin tocl g l obvious higher tcm ch addit unknown product form uvchlorin treatment detect mass spectrometri high confid level includ monochloro dbps dichloro dbps although uvchlorin process acceler sdbs degrad associ dbp format deserv enough attent | D018508;D014874 | T057;T131;T052 |
36,241,112 | insight algicid characterist bacillus altitudini g dysfunct photosystem overproduct reactiv oxygen speci cyanobacteri bloom negat affect aquat ecosystem human health algicid bacteria effici kill bloom caus cyanobacteria bacillus altitudini g isol dianchi lake show high algicid activ microcysti aeruginosa studi investig algicid characterist includ attack mode photosynthesi respons sourc contribut reactiv oxygen speci ros result show g effici specif kill aeruginosa main releas thermolabil thermost algicid substanc exhibit highest algicid activ h bacteri mid logarithm growth phase algicid ratio full light condit h signific higher dark condit p g filtrat caus photosystem dysfunct decreas photosynthet effici indic signific decreas f v f pi ab p valu also inhibit photosynthet electron transfer indic signific decreas retr p especi q downstream reveal signific decreas e increas p result indic algicid activ g filtrat light depend cyanobacteri photosystem import target cyanobacteri ros malondialdehyd content great increas h respect ros level decreas h diuron dichlorophenyl dimethylurea partial block photosynthet electron transport q q b therefor excess ros produc disrupt photosynthesi especi inhibit electron transport area q downstream caus sever lipid peroxid signific increas mda content oxid stress cyanobacteria ros scaveng n acetyl l cystein signific decreas cyanobacteri ros level algicid ratio p h thus excess ros product due g filtrat administr signific contribut algicid effect g could excel algicid control aeruginosa bloom water suitabl light condit | D001407;D046931 | T007 |
36,241,111 | benthic foraminifera environment proxi pollut along coast chennai india benthic foraminifera increas use indic environment disturb sensit pollut reflect chang assemblag provid use inform ecosystem health studi aim investig impact organ inorgan pollut benthic ecolog chennai coast focus oil spill caus collis two ship sediment sampl collect five distinct zone along coast analys pollut polycycl aromat hydrocarbon pah total petroleum hydrocarbon tph heavi metal cr cd pb total organ carbon toc maximum concentr cr gg cd gg pb gg well tph gg pah ngg observ total speci foraminifera identifi studi morpholog abnorm low impact zone speci divers index h higher tph pah concentr posit associ abnorm speci pollut resist foraminifera speci includ ammonia tepida elphidium discoidal quinqueloculina lamarckiana opportunist foraminifera includ pararotalia curryi nonionella stella rosalina globulari spirillina vivipara pah heavi metal advers correl foraminifer abund tph posit correl assess respons benthic ecosystem hydrocarbon pollut indic foraminifer index environment impact fiei exponenti h bc index foraminifer abnorm index fai use environment health proxi fiei exp h bc fai valu show impact hydrocarbon pollut extent along northern chennai coast | D056908;D004785;D014874;D019216;D011084 | T196;T109;T131;T204 |
36,241,110 | hazard organ pollut indoor dust elementari school kindergarten greec implic children health children spend signific portion day school may expos hazard organ compound accumul indoor dust aim studi evalu concentr major hazard organ contamin dust collect kindergarten elementari school northern greec n sum concentr target polybromin diphenyl ether congen pbdes dust vari ng g ng g sum novel bromin fire retard nbfrs rang ng g ng g correspond sum concentr phthalat ester pae rang g g g g sum organophosph ester ope found ng g ng g final sum concentr polycycl aromat hydrocarbon pah found within rang ng g ng g exposur indoor dust contamin via inhal ingest dermal absorpt investig children adult teacher carcinogen non carcinogen risk also estim children estim intak individu hazard chemic via three exposur rout lower avail health base refer valu | D004785;D016902;D005411;D011084 | T131;T120;T069;T109;T080 |
36,241,109 | ceo modifi carbon nanotub electrifi membran remov antibiot electrifi carbon nanotub membran ecm use electroact porous materi degrad micropollut integr design electrochem process filtrat function studi ceo modifi carbon nanotub electrifi membran ceo cnt membran prepar activ naclo toward degrad antibiot ceo face center cubic fcc fluorit structur load onto cnt sidewal ceo cnt membran show higher potenti smaller equival polar resist compar ecm reactiv oxygen speci ros reactiv chlorin speci rcs generat ceo cnt membran due faster electron transfer solid liquid interfac thus remov effici dcf smx cip tc cbz ceo cnt membran naclo respet appar reaction rate constant k ceo cnt membran time ecm select cap experi densiti function theori dft calcul show oxygen vacanc ceo contribut generat oh generat clo would main occur lewi acid site ceo addit ceo cnt membran show reason stabil treat actual water sampl reduc disinfect byproduct dbps format suggest potenti combin convent chlorin disinfect degrad antibiot water | D037742 | T104;T073 |
36,241,108 | integr bismuth sulfidefunction halloysit nanotub composit electrochem tool diethofencarb analysi diethofencarb dfc fungicid use agricultur field over use make negat impact real time environ work semi conduct urchin like bismuth sulfid bi anchor tubular structur function halloysit nanotub f hnt hydrotherm synthes use electrochem detect dfc various analyt microscop techniqu use analyz structur crystallin natur puriti prepar f hnt bi moreov cyclic voltammetri techniqu use analyz electrochem studi f hnt bi modifi glassi carbon electrod gce high synerget relationship bi f hnt provid larg surfac area better detect dfc amperometri techniqu result show prepar composit exhibit wide linear rang g l low detect limit g l good stabil notabl propos sensor determin dfc spike tomato water sampl high recoveri rang proven viabil real time analysi final mention studi result prove f hnt bi could use electrochem probe detect dfc | D055664;D043942 | T059;T073 |
36,241,107 | mitig protein foul magnesium ion relat mechan ultrafiltr process although protein import membran foulant water bodi may signific affect coexist common cation magnesium mg effect mg protein foul rare report context studi select bovin serum albumin bsa model foulant investig foul characterist differ mg concentr mm filtrat test show protein foul signific mitig ad mg specif filtrat resist sfr pure bsa kg least time bsa mg solut mm addit optim mg concentr exist achiev lowest bsa sfr seri character indic main contributor differ bsa sfr chang bsa adhes capac thick structur foulant layer basic result attribut hydrat repuls effect mg prevent tight adhes foulant membran moreov lowest bsr sfr mm mg achiev hydrat repuls effect also particl size compress due conform chang bsa molecul combin effect led lowest foulant retent membran surfac deliv lowest sfr studi conduct thorough inspect specif effect mg protein foul provid fresh insight protein foul control uf process | D014462;D018508 | T061;T057;T052 |
36,241,106 | environment relev uptak elimin metabol chang follow earli embryon exposur tetrachlorodibenzo p dioxin zebrafish dioxin dioxin like compound ubiquit environment contamin induc toxic bind aryl hydrocarbon receptor ahr ligand activ transcript factor zebrafish model use defin development toxic observ follow exposur exogen ahr ligand potent agonist tetrachlorodibenzo p dioxin dioxin tcdd model success identifi cellular target tcdd molecular mechan mediat tcdd induc phenotyp fundament inform bodi burden produc standard exposur model still unknown perform target gas chromatographi gc high resolut mass spectrometri hrms tandem non target liquid chromatographi lc hrms quantifi tcdd uptak model elimin dynam tcdd determin tcdd exposur affect zebrafish metabolom found ppt ppb ppb waterborn exposur tcdd earli embryogenesi produc environment relev bodi burden pgembryo respect hour post fertil tcdd exposur associ dysregul metabol pathway associ ahr signal pathway well pathway shown affect mammal follow tcdd exposur addit discov tcdd exposur affect sever metabol pathway critic brain develop function includ glutam metabol chondroitin sulfat biosynthesi tyrosin metabol togeth data demonstr exist exposur method produc environment relev bodi burden tcdd zebrafish provid insight biochem pathway impact toxic induc ahr activ | D000072317;D004147 | T121;T109;T131 |
36,241,105 | spatiotempor differ riverin nitrogen phosphorus flux associ driver across china increas nutrient load waterway past four decad led widespread eutroph water qualiti impair across china understand spatial interannu long term variat nutrient load associ driver nation scale crucial develop effect nutrient reduct strategi howev control spatiotempor variat nutrient flux remain problem academ manag perspect studi provid spatial extens tempor contigu estim chang riverin total nitrogen tn ammonia nitrogen nh n total phosphorus tp flux continent area china base machin learn stack model empir model period result reveal consider spatial interannu long term variabl annual tn nh n tp flux spatial variat averag tn nh n flux primarili driven net anthropogen nitrogen input interannu variabl domin precipit across continent area china spatial variabl estim averag annual tp flux undevelop western develop middl east region china primarili control net anthropogen phosphorus input precipit respect found tn nh n tp flux increas watersh east china nation mean annual tn nh n tp flux increas decreas studi illustr import role precipit temperatur variabl control spatial interannu long term variabl nutrient flux indic influenc meteorolog condit annual load need design watersh nutrient reduct manag strategi | D010758;D014874 | T131;T196;T197 |
36,241,104 | soybean rhizospher microorgan allevi mo nanomateri induc stress improv soil microbi communiti structur wide applic nanomateri nms agricultur particular import assess impact nms soil microorgan studi differ varieti soybean rhizospher microorgan rm employ simul allevi effect molybdenum nanoparticl mo nps induc stress presenc soybean plant mo nps caus serious toxic effect soybean growth nitrogen fixat concentr mg kg plant height biomass reduc respect abil fix nitrogen almost lost howev ad differ varieti soybean rm rm william rm youchun rm zhongdou stress caus high concentr mo nps soybean plant signific reduc plant height root length biomass nitrogen fixat abil improv respect follow addit soybean rm william high throughput sequenc reveal mo nps treatment affect microbi communiti structur among flavisolibact caulobact genera abund increas signific might key factor reliev mo nps induc stress soybean growth find suggest novel mode rm promis strategi prevent deleteri effect stress nps plant futur | D064307;D007887;D049329 | T073;T002;T028;T001;T032 |
36,241,103 | morpholog element tune bioclbivo heterostructur uric acid electrochem sensor antibiot photocatalyt degrad deep eutect solvent des consist eg chcl c h tu chcl ch n assist synthes bioclbivo heterostructur catalyst studi electrochem uric acid ua sensor tetracyclin photocatalyt degrad chemic composit bioclbivo catalyst analyz x ray photoelectron spectroscopi xps uv vis spectroscopi reveal increas absorpt visibl light till near infrar region result narrow band gap energi ev ev bioclbivo tu morpholog catalyst analyz use field emiss scan electron microscop fe sem transmiss electron microscop tem techniqu time resolv photoluminesc trpl confirm increas lifetim e h pair heterostructur format catalyst modifi glassi carbon electrod show select toward detect uric acid ua limit detect lod estim ua also interfer stabil catalyst studi photocatalyt activ synthes catalyst investig degrad tetracyclin tc antibiot pollut intermedi product analyz ion trap mass spectrometri ms | D001729;D014527 | T121;T109;T196;T123;T114 |
36,241,102 | synergist role situ zr dope cobalt oxid cocatalyst photocatalyt bacteri inactiv organ pollut remov templat free fe nanorod herein synthes situ zr dope fe nrs photocatalyst success simpl hydrotherm air quench method synergist role coo x wt zr dope bacteria inactiv model organ pollut fe nrs photocatalyst studi detail initi rod like zr dope fe nrs produc via hydrotherm method coo x load onto zr dope fe nrs surfac wet impregn approach zr dope condit coo x load judici optim high photoact coo x wt zr dope fe nrs photocatalyst develop coo x wt load zr dope fe nrs photocatalyst reveal inactiv effici compar zr dope fe nrs respect coo x wt zr dope fe nrs photocatalyst treatment bio tem imag bacteri cell show extens morpholog deviat cell membran compar non treat one addit optimum coo x wt zr dope fe nrs photocatalyst exhibit bpa orang ii dye degrad light radiat h work provid rapid method develop photost catalyst materi bacteri disinfect organ degrad | D004785;D043942 | T131;T073 |
36,241,101 | investig potenti impact coal ash runoff freshwat seminol ramshorn snail planorbella duryi laboratori condit coal fli ash industri wast product generat coal fire powerpl shown contain elev concentr sever toxic trace metal store landfil repositori trace metal enter nearbi surfac water via number rout includ leach runoff studi examin presenc concentr eleven trace element rang lab creat coal ash leachat solut neutral ph use icp oe physiolog effect leachat solut freshwat gastropod planorbella duryi abil trace metal bioaccumul tissu expos individu cd cu mg mn pb detect solut increas concentr concurr ash concentr exposur leachat caus signific delay embryon develop reduc juvenil shell growth decreas egg clutch product display avoid behavior tissu expos snail contain elev concentr cd cu cr bioconcentr factor time higher cadmium time higher arsenic highest treatment compar control organ result highlight potenti harm effect coal ash leachat novel freshwat invertebr speci use sever uniqu methodolog provid key inform regard potenti impact surround aquat ecosystem | D014131;D019216 | T121;T123;T196 |
36,241,100 | soil exposur major fluorid exposur pathway resid high fluorid karst region southwest china karst area southwest china soil fluorid level higher china mg kg world mg kg high level f environ might pose health risk human comprehens exposur risk must studi area herein sampl crop soil collect biji citi typic karst area southwest china investig pollut level evalu comprehens f exposur risk singl factor index p fw geolog accumul index geo use hazard index hi appli assess exposur risk multipl exposur rout result reveal consider f contamin soil crop studi area averag soil total fluorin ft mg kg soil water solubl f fw mg kg corn rice wheat potato f content mg kg respect mean valu hi children adult respect show potenti health risk exist youngster greater exposur risk adult result contribut ratio differ exposur rout health risk major exposur risk determin soil exposur base suggest risk manag main strive control soil fluorid level implement risk educ communic | D012989;D019216 | T131;T196 |
36,241,099 | therapeut inhibit topoisomeras inhibitor crizotinib combin egfr wild mutant lung cancer cell combin therapi enhanc therapeut effect activ multipl downstream pathway present studi aim investig novel strategi success inhibit egfr pathway egfr wild mutat type lung cancer combin method topotecan tpt crizotinib cri use evalu effect egfr wild primari secondari mutant non small cell lung cancer nsclc cell line h hcc h cell combin group signific inhibit lung cancer growth combin index ci synergist induc cell apoptosi disrupt balanc bax bcl xl loss mitochondri membran potenti mmp accumul reactiv oxygen speci ros addit egfr downstream signal pathway includ akt erk jnk p mapk regul treat combin regimen meanwhil nano liposom co load cri tpt prepar exhibit strong cytotox lung cancer cell especi h h cell anim studi confirm synergi tpt cri result remark repress tumor growth inhibit rate nano liposom tpt cri achiev optim curat effect inhibit rate mgkg moreov synergist mechan combin consist vitro cell experi regul egfr signal pathway collect propos preclin rational potenti formul use combin therapi consist topoisomeras inhibitor tpt alk tki cri treatment lung cancer | D008175;D002289 | T191 |
36,241,088 | mechan insight licoric flavonoid releas carbopol hydrogel role releas steric hindranc drug solubl releas medium present studi systemat evalu differ licoric flavonoid lfs compound releas behavior singl payload hydrogel lfs extract hydrogel base drug solubl releas medium dsrm intermolecular strength hydrogel releas steric hindranc rsh two kind lfs lfs lfs ww hydrogel prepar carbopol cbp thicken ten lfs singl payload hydrogel prepar accord actual content lfs extract drug releas mechan confirm vitro releas experi molecular dynam simul analysi evalu use novel indic er lfs sin enhanc ratio er drug releas percent lfs cbp hydrogel singl payload hydrogel er lfs lfs er drug releas percent lfs cbp hydrogel lfs cbp hydrogel er releas medium er drug releas percent differ releas medium found lfs cbp possess signific higher intermolecular strength rsh lfs cbp result higher viscos posit correl payload content negat correl drug releas percent therefor er lfs lfs valu ten lfs compound higher liquiritigenin retrochalcon higher dsrm display similar er lfs sin er lfs lfs er releas medium valu formononetin licoflavon licochalcon low dsrm exhibit er lfs sin valu low dsrm decis factor restrict releas singl payload hydrogel presenc glycyrrhizin acid ga lfs could facilit releas lfs extract hydrogel isoliquiritin isoliquiritigenin glabridin lower content lfs extract exhibit er lfs sin valu rsh predomin restrict releas studi provid guidelin reason design lfs extract hydrogel pharmaceut topic formul | D006035 | T002 |
36,241,086 | cypd brain impact oral hydrocodon analgesia vivo cytochrom p cypd metabolis mani central act substrat includ opioid hydrocodon opioid cypd substrat metabolis hydromorphon activ metabolit cypd brain activ vivo alter drug respons howev unknown whether metabol cypd brain alter oral hydrocodon induc analgesia propranolol select cypd mechan base inhibitor vehicl administ right cerebr ventricl male rat han wistar envigo h test analgesia oral hydrocodon hydromorphon non cypd substrat hydrocodon cypd mediat metabolit simultan quantifi use novel lc msms assay propranolol vs vehicl pretreat signific higher analgesia oral hydrocodon signific lower brain cypd metabol ratio vivo phenotyp brain cypd activ deriv molar sum hydromorphon metabolit divid hydrocodon brain cypd metabol ratio correl signific analgesia pretreat effect plasma hydrocodon concentr elimin rate metabol ratio vivo phenotyp hepat cypd activ liver cypd metabol ratio correl analgesia propranolol pretreat impact analgesia oral hydromorphon data suggest inhibit cypd activ brain caus reduc metabol brain hydrocodon result higher analgesia oral hydrocodon despit hydrocodon lower opioid receptor affin hydromorphon thus variat cypd brain may import sourc interindividu differ respons cypd substrat includ oral hydrocodon | D006853;D000698 | T121;T061;T109 |
36,241,085 | usag l type calcium channel blocker suppress drug reward memori drive addict past present futur past three decad l type ca channel ltcc blocker consid potenti therapeut drug allevi symptom drug addict idea support part express ltccs brain dopaminerg circuit thought play critic role develop express addict behavior common usag ltcc blocker treat hypertens may enabl label use drug good brain penetr therapeut brain disord addict view maladapt form learn power memori drug associ stimuli action drive compuls drug intak larg framework focus dopaminerg system thought critic involv drug associ learn memori provid brief overview past recent studi test therapeut potenti ltcc blocker addict disord anim model human offer futur perspect use ltcc blocker drug addict possibl addict non drug reward eg gambl eat shop interest reader refer relat articl issu comprehens review avail elsewher littl gain insight role ltccs drug addict withdraw symptom associ depend articl part special issu l type calcium channel mechan neuropsychiatr disord | D016739;D019966 | T048;T033 |
36,241,082 | selenoprotein versatil disord protein selenoprotein seleno small intrins disord membran protein associ various cellular function inflammatori process cellular stress respons protein qualiti control signal pathway primarili known contribut er associ degrad erad pathway govern extract misfold protein misassembl protein complex er cytosol degrad proteasom howev seleno cellular role signal equal vital includ control transcript factor cytokin level consequ genet polymorph seleno associ increas risk diabet dyslipidemia cardiovascular diseas high express level correl poor prognosi sever cancer inhibitori role cytokin secret also exploit virus sinc seleno bind multipl protein complex howev specif contribut various cellular pathway diseas difficult establish thus precis cellular function seleno interconnect recent begun emerg review aim summar recent insight structur interactom cellular role seleno | D051140;D008565 | T123;T116;T192 |
36,241,077 | silico design cmv promot bind oligonucleotid impact inhibit gene express chines hamster ovari cell modul express level endogen recombin gene great interest divers applic studi genotyp phenotyp relationship gene interest fine tune transcript determin physiolog relev effect gene express level last decad sever synthet biolog tool establish control gene express mammalian cell chines hamster ovari cho cell one import cell system basic research well product biopharmaceut describ use triplex form oligo tfos short rna ssdna molecul bind major grove target duplex great specif control transgen express cho cell proof concept panel tfos size nts design help line tool triplex target viral cytomegalovirus cmv promoterenhanc region control downstream report gene hcd effect tfos test ssdna oligo pre anneal promoterenhanc region vitro well upon endogen transcript tfo rna molecul bind target duplex vivo result show bind tfo exact locat triplex format within promoterenhanc paramount transcript inhibit reliev bind conflict introduc point mutat within cmv promot longer tfos nts could design analys select tfos achiev reduct recombin hcd express cho k cell | D001688;D003586 | T121;T047;T123 |
36,241,049 | long term effect prenat stress develop prefront cortex adolesc offspr exposur stress pregnanc consequ prompt long last effect fetal brain develop predispos offspr mental ill later life adolesc vulner period prefront cortex pfc develop coincid onset neuropsychiatr symptom medial pfc mpfc brain area play signific role emot process stress alter function brain area lead emot disord microglia play role neuroinflammatori respons also play crucial role brain develop especi synapt develop prune previous studi reveal long term effect prenat stress ps microglia activ neuroinflamm hippocampus offspr howev still need investig ps alter mpfc develop adolesc studi examin effect matern stress last week gestat microglia activ neuroimmun respons mpfc adolesc offspr morpholog studi demonstr ps increas densiti activ microglia prelimb region mpfc adolesc offspr besid ps signific increas level microglia marker iba interleukin il brain deriv neurotroph factor bdnf mpfc adolesc offspr conclus ps induc microglia activ neuroinflamm mpfc might increas risk neuropsychiatr disord offspr later year | D017397;D011297 | T023;T030;T037;T029 |
36,241,030 | mri base composit paramet multipl tissu type improv patient level hemispher region level later pediatr epilepsi although voxel base morphometri vbm gray matter gm white matter wm cerebrospin fluid csf chang aid epilept seizur later type puls sequenc preprocess step tissu segment method lead variat tissu classif test predict accuraci individu mri base tissu type novel composit ratio paramet gm wm csf sensit parenchym chang independ tissu classif variat pediatr patient partial seizur simpl complex normal lesion free mri consid patient unilater eeg femal male age mean sd year mri base seizur later perform patient verifi eeg find alon combin seizur semiolog weight mri patient normal control subject spatial transform talairach atlas automat segment gm wm csf tissu type age match normal control femal male age mean sd year serv null distribut test tissu type deviat across epilepsi patient verifi patient eeg predict wm gm csf hemispher match respect composit ratio gm wm csf show highest accuraci eeg find seizur semiolog combin mri predict use composit ratio improv local epilept focus region level frontal tempor pariet occipit mri predict obtain composit ratio perform accuraci reveal region mri chang predict eeg result show inconsist chang gm wm major pediatr epilepsi patient demonstr applic composit ratio gm wm csf superior predictor independ tissu classif variat clinic eeg find combin seizur semiolog overcom scalp eeg limit lean toward mri later specif case | D066127;D004827 | T023;T024;T047;T033 |
36,241,023 | applic lipidom goat meat product biomark structur nutrit interfac futur perspect goat meat superior product includ low lipid low cholesterol content high qualiti protein becom superior food nation market increas demand goat meat product sensori qualiti physicochem properti goat meat also wide observ follow signific discoveri mechan determin goat meat qualiti research complex interact factor lead chang goat meat qualiti increas base data driven omic method lipidom rapid identifi quantifi lipid speci time facilit comprehens analys lipid tissu molecular mechan biomark indic chang goat meat qualiti authent meat analogu nutrit health lipidom feasibl accord analysi result class differ biomark lipid goat meat qualiti main process involv biosynthesi unsatur fatti acid associ lipid protein lipid oxid lipid hydrolysi lipid degrad lipid deposit lipid denatur translat advanc technolog identifi goat meat adulter faux meat rapid accur signific review research lipidom technolog past applic recent find common recent advanc lipidom qualiti assess mutton product lipidom ms approach summar inform report review serv refer character lipid found mutton clarifi applic lipidom field mutton product provid new perspect produc superior qualiti mutton product | D000081362;D008461 | T091;T168;T109 |
36,241,018 | decod semant intermodul respons frequenc tag stereotact eeg human perform object recognit use holist process differ comput intermodul respons steadi state visual evok potenti ssvep scalp electroencephalographi eeg recent use object label holist process | D005074;D062207 | T074;T042 |
36,241,007 | detect aquat pathogen field compat dri qpcr assay field readi qpcr assay extend shelf life support monitor program emerg aquat pathogen enabl quick conserv manag decis develop valid test shelf life qpcr assay target gyrodactylus salari aphanomyc astaci lyophil air dri | D003400;D044744 | T204 |
36,241,006 | pmtl modular plasmid vector seri parageobacillus thermoglucosidasius strain engin parageobacillus thermoglucosidasius promis chassi produc chemic fuel design built test pmtl modular plasmid contain standardis gram posit gram negat replicon select marker applic specif modul pmtl modular plasmid characteris regard transform effici segreg stabil copi number compat | D005822;D001406 | T007;T114 |
36,241,001 | specif delet cyclooxygenas megakaryocytesplatelet reduc intestin polyposi apcmin mice clinic experiment evid sustain role cyclooxygenas cox intestin tumorigenesi howev cell type express enzym involv molecular mechan clarifi yet aim elucid role platelet cox target low dose aspirin human intestin tumorigenesi apcmin mice consid clinic relev model realiz object generat apcmin mous specif delet ptgs cox gene name megakaryocytesplatelet apcmin pptgs mice character profound inhibit thromboxan tx biosynthesi ex vivo serum txb vivo urinari dinor txb txm apcmin mice delet platelet cox show signific reduc number size tumor small intestin intestin adenoma mice decreas prolif index associ reduc cox express system prostaglandin pg e biosynthesi urinari pgem vs apcminmic extravas platelet detect intestin apcminmic thus explor contribut cox induct fibroblast consid primari polyp cell type express protein cocultur human platelet myofibroblast platelet deriv txa involv induct cox depend pge myofibroblast sinc prevent select inhibit platelet cox aspirin specif antagonist txa receptor conclus result support platelet hypothesi intestin tumorigenesi provid experiment evid select inhibit platelet cox mitig earli event intestin tumorigenesi restrain cox induct | D008533;D044483 | T025;T047 |
36,241,000 | nanomicell co load cxcr antagonist doxorubicin combat refractori acut myeloid leukemia acut myeloid leukemia aml featur poor prognosi high mortal chemo resist nonspecif distribut dose limit toxic lead high rate relaps low year surviv percentag less cxcr high express chemokin receptor multipl type aml cell close associ drug resist relaps work integr chemic synthes cxcr antagonist peptid doxorubicin use dspe mpeg micell refer e dox appli challeng refractori aml mous model well human aml cell line result show e dox effect bind cxcr express aml cell downregul signal protein mediat cxcrcxcl axi increas cellular uptak dox import e dox remark decreas leukem cell peripher blood bone marrow well infiltr spleen liver aml mice turn prolong surviv signific meanwhil e dox increas cardiotox dox conclus e dox har function cxcr specif bind cxcr antagon peptid tumor cell kill capac dox display signific therapeut effect promis translat potenti treatment refractori aml | D015470 | T191 |
36,240,979 | vitro vivo silico evalu analges anti inflammatori anti pyret activ salicyl rich fraction gaultheria trichophylla royl ericacea medicin properti gaultheria use tradit medicin treat pain inflamm | D031282;D058633;D029791 | T121;T002;T039 |
36,240,978 | biejiajian pill inhibit progress hepatocellular carcinoma downregul pdgfr signal cancer associ fibroblast biejiajian pill bjjp canon formula clinic use treat chronic liver diseas especi decreas incid hepatocellular carcinoma hcc howev mechan under prevent hcc progress bjjp remain unclear | D006528;D000072645;D008113 | T191;T025 |
36,240,977 | overlook switch transient sedat sustain excit biphas effect ephedra herb extract administ oral mice previous studi report ephedra herb extract ehe increas locomotor activ mice open field test reduc immobl time forc swim test ephedrin alkaloid ea thought respons advers effect ephedra herb howev report verifi advers effect ephedra herb caus amount ea herb therefor investig whether advers effect ehe caus amount ephedrin eph pseudoephedrin pse herbal extract preliminari studi time cours analysi open field test newli observ ehe evok switch transient sedat sustain excit | D029789;D000470 | T002;T131;T121;T109;T123 |
36,240,976 | fufang zhenzhu tiaozhi formula protect islet injuri promot cell regener diabet mice fufang zhenzhu tiaozhi formula ftz patent prepar tradit chines medicin use treat hyperglycemia hyperlipidemia clinic almost year previous studi demonstr ftz protect islet cell injuri vitro howev efficaci ftz cell regener vivo involv anti diabet mechan remain unknown | D003924;D003921;D007515;D008687 | T050;T047;T023;T121;T109 |
36,240,970 | model fate ioniz pharmaceut person care product ippcp soil plant system ph speciat model develop simul ph depend speciat fate ioniz pharmaceut person care product ippcp soil plant uptak thedt applic reclaim wastewat agricultur soil simul show ph play import role regul plant uptak ippcp ie ibuprofen ibu carboxyl group triclosan tcs phenol group fluoxetin fxt amin group model compound took day various ippcp reach steadi state concentr soil plant tissu simul steadi state concentr ippcp plant tissu ph time ph ibu tcs fxt respect assum sorption neutral compound led miscalcul ippcp concentr plant tissu one half order magnitud efflux compound soil lettuc leaf soybean pod primarili contribut degrad soil dilut due plant tissu growth overal result demonstr import consid ph speciat ippcp simul fate soil plant system plant uptak | D012989;D003358;D014260 | T073;T167;T131;T121;T109 |
36,240,969 | degrad uv p mediat hydroxyl radic sulfat radic singlet oxygen aquat solut dft experiment studi hydroxi methylphenyl benzotriazol uv p type emerg persist organ pollut report harm organ howev degrad mechan transform behavior aquat environ yet clear signific better understand environment fate potenti toxicolog impact present work degrad mechan kinet half life time eco toxic assess uv p initi hydroxyl radic oh sulfat radic singlet oxygen systemat studi use densiti function theori dft experiment method initi reaction result show benzen ring uv p vulner attack oh benzotriazol easili attack kinet calcul indic oh addit reaction r domin initi pathway half life uv p calcul accord rate constant decreas rapid ros increas uv p exhibit environment persist oh subsequ degrad mechan hydroxyl uv p react oh also calcul novel ring open reaction channel propos addit intermedi combin hydroperoxyl radic ho cleav aromat ring rate determin step intramolecular dehydr reaction energi barrier kcal mol kcal mol cleav benzen ring benzotriazol ring respect degrad experi uv p conduct co activ potassium peroxymonosulf pms system liquid chromatograph mass spectromet lc ms result identifi dihydroxyl speci main intermedi consist theoret calcul result furthermor eco toxic assess show acut chronic toxic degrad product reduc compar uv p howev toxic level still keep toxic harm environment risk uv p deserv attent | D017665;D014874 | T131;T197 |
36,240,968 | samt sedum alfredii drive cd detoxif chelat ros scaveng via cys residu metallothionein mts group cystein rich protein effect chelat cadmium cd play key role plant cd detoxif howev littl known role singl cystein cys residu mts involv adapt plant cd stress especi hyperaccumul present studi function characteris samt alfredii cdzn hyperaccumul nativ china result show c n termin region samt differenti function natur alfredii determin cd hypertoler detoxif two cxc motif within c termin region reveal play crucial role cd sens bind wherea four cys residu within n termin region involv scaveng reactiv oxygen speci ros alfredii transgen system base callus transform develop investig planta gene function samt overexpress transgen plant root toler cd wild type plant knockout samt result signific decreas cd concentr increas ros level exposur cd stress demonstr samt mediat adapt strategi alfredii use metal chelat ros scaveng respons cd stress result reveal molecular mechan under cd detoxif hyperaccumul plant well relat cys relat motif metal bind properti mts research provid valuabl insight function samt alfredii improv understand cd hyperaccumul plant | D031963;D012989 | T131;T002 |
36,240,967 | cgas sting autophagi pathway novel perspect neurotox induc manganes exposur chronic high level heavi metal exposur increas risk develop differ neurodegen diseas chronic excess manganes mn exposur known lead neurodegen diseas addit evid suggest autophagi dysfunct play import role pathogenesi various neurodegen diseas past decad dna sens receptor cyclic gmp amp synthas cgas downstream signal effici interferon gene stimul sting well molecular composit regulatori mechan pathway well understood cgas sting pathway emerg crucial mechan induc effect innat immun respons induc type interferon mammalian cell moreov recent studi found mn second activ cgas sting pathway besid dsdna induc autophagi primit function activ cgas sting pathway howev overactiv immun respons lead tissu damag review discuss mechan neurotox induc mn exposur cgas sting autophagi pathway futur work exploit cgas sting autophagi pathway may provid novel perspect manganes neurotox | D008345;D008565 | T192;T123;T116;T196 |
36,240,966 | systemat review microplast pollut water sediment organ coastal lagoon across globe coastal lagoon transit environ continent marin aquat system global coastal lagoon great ecolog socioeconom import provid valuabl ecosystem servic howev fragil environ subject sever human pressur includ pollut microplast mps aim review identifi summar advanc mp pollut research coastal lagoon across world consid peer review public topic publish english spanish april avail scopus googl scholar found public data mp abund characterist coastal lagoon around world environment protect status number public type pollut lagoon increas signific sinc methodolog differ amongst studi mps coastal lagoon nevertheless limit factor wide rang comparison studi conduct singl environment compart integr limit hamper current understand mp dynam lagoon mps abund lagoon high popul shore watersh support intens human activ contrari lagoon natur protect area lower abund mps most sediment organ fiberfila fragment shape polyethylen polyest polypropylen polym predomin mps accumul certain area coastal lagoon export sea depend influenc season weather hydrodynam anthropogen pressur typolog mps advis futur research mp pollut coastal lagoon focus methodolog aspect assessmentmonitor pollut mp dynam impact prevent measur part sound environment manag | D000080545;D014874 | T131;T122 |
36,240,964 | atmospher sulfat format seoul metropolitan area springsumm effect trace metal ion despit effort control emiss sulfat still one major inorgan compon pm urban area moreov still lack understand sulfat format mechan via oxid various ambient condit studi focus sulfat format haze pollut episod springsummertim seoul metropolitan area sma pollut episod pm mass concentr exceed g sulfat account total pm mass concentr sharp increas sulfur oxid ratio sor valu along aerosol liquid water content awc humid condit could ascrib appar contribut aqueous phase oxid sulfat format pollut period comparison sor valu four repres oxid aqueous phase oxid ie h tmis indic tmis concentr especi mn ii show best posit correl furthermor calcul sulfat product rate contribut tmis concentr found domin within ph rang sma determin chemic composit deriv awc result impli emiss also chemic compon eg tmi nitrat would play critic combin role sulfat format urban haze condit | D000393;D014131 | T121;T131;T123;T196 |
36,240,963 | bacteri colon dynam differ microplast type anox salt marsh sediment impact adsorb polychlorin biphenyl plastispher plastic debri dispers environ provid substrat microbi colon constitut new human made ecosystem call plastispher alter microbi speci distribut aquat coastal benthic ecosystem studi aim explor interact among microplast mps made differ polym persist organ contamin polychlorin biphenyl pcbs environment microbi communiti anox marin sediment plastic pellet incub field salt marsh anox sediment observ stage plastispher format quantit pcr rrna gene sequenc pcb dechlorin activ mps surfac microb sediment rapid colon differ microplast type pvc recruit peculiar communiti enrich sulfat reduc bacteria composit plastispher vari along year incub possibl respons either warmer temperatur spring summer microhabitat chang due progress plastic surfac weather even pcb contamin mps abl recruit potenti dehalogen taxa actual dechlorin detect year suggest concentr potenti dehalorespir bacteria natur environ could low onset dechlorin process mp sorb contamin studi among avail longitudin explor plastispher composit anox sediment context first explor fate possibl biodegrad persist organ pollut sorb mps reach seafloor | D011078;D064307 | T131;T028;T001;T109;T032 |
36,240,962 | air qualiti index predict use effect hybrid deep learn model environment becom intrins part everyday life one greatest challeng environ long term exist air pollut delhi capit india experienc decreas air qualiti sever year poor air qualiti signific impact live individu air qualiti index aqi predict help beneficiari take safeguard health move pollut area studi varieti data forecast approach evalu predict aqi valu particul matter pm particular area delhi sever error prone strategi r squar r mean absolut error mae root mean squar error rmse method catalogu propos approach two deep learn model like long short term memori lstm gate recurr unit gru combin predict aqi environ sever stand alon machin learn ml deep learn dl model lstm linear regress lr gru k nearest neighbor knn support vector machin svm also train dataset compar perform propos hybrid lstm gru model found propos hybrid model show supremaci perform mae valu r valu | D000077321;D000397 | T069;T066;T080 |
36,240,961 | contrast divers pattern communiti assembl mechan bacterioplankton among differ aquat habitat lake taihu larg eutroph shallow lake china eutroph lead degrad lake habitat type macrophyt domin habitat mdh alga domin habitat adh common environment problem face mani lake howev variat divers communiti assembl process bacterioplankton process lake eutroph thorough elucid contrast bacteri divers pattern process communiti assembl among adh mdh habitat oh lake taihu larg shallow eutroph lake china strong wind induc disturb found bacteri divers pattern potenti function adh mdh signific differ moreov contribut pure environment variabl bacteri divers pattern habitat type much higher spatial variabl howev relat import stochast bacteri communiti assembl habitat type much higher determin intrigu undomin stochast process shape divers pattern bacterioplankton adh mdh oh lake taihu find demonstr degrad lake habitat caus eutroph profound chang divers potenti function pattern bacterioplankton communiti lake ecosystem although distinct divers pattern bacterioplankton among differ aquat habitat lake taihu affect determinist process local environment variabl domin stochast process drift studi confirm strong disord wind induc disturb shallow lake could lead strong hydrolog mix thus increas random bacteri communiti assembl habitat | D060106;D017753 | T082;T083;T070 |
36,240,950 | environment enrich counteract effect glioma primari visual cortex experi depend neuron chang brain plastic occur throughout life anim adapt environ structur morpholog cellular modif promot exposur environment enrich ee report improv neuron function increas hippocamp neurogenesi amelior memori task cognit perform benefici effect sever brain diseas includ cancer specif address role ee counteract neuron dysfunct mice bear glioma primari visual cortex record spontan evok current patch clamp techniqu acut slice obtain standard enrich hous mice found presenc glioma global reduc excitatori inhibitori transmiss peritumor area exposur enrich environ counteract tumor mediat depress excitatori inhibitori neuron activ pronounc impact evok transmiss effect ee glioma also associ reduc tumor cell prolifer result elucid impact ee excitatori inhibitori neurotransmiss primari visual cortex control glioma bear mice | D000087642;D005910 | T191;T029 |
36,240,949 | ccl recruit fetal microchimer cell dampen matern brain damag post partum mice prevent brain cell loss enhanc tissu repair crucial object improv outcom stroke fetal microchimer implic brain repair follow ischem stroke mice cclccr signal pathway trigger fetal progenitor traffick cutan wound therefor sought evalu whether ccl could dampen brain damag model excitotox lesion post partum mice virgin post partum mice subject intracerebr inject iboten induc excitotox lesion low dose ccl vehicl concomit inject morpholog molecular analys perform day follow procedur intracerebr treatment low dose ccl abl limit brain excitotox damag induc iboten post partum mice enhanc recruit fetal microchimer cell damag hemispher day post inject observ decreas cortic apoptosi associ reduc reactiv astrocytosi day found increas proport matur neuron oligodendrocyt correl increas gap growth cone stage immun microgli cell reduc angiogenesi enhanc import ccl benefici effect virgin mice therefor rule specif role ccl independ fetal microchimer cell mobil ccl treatment effici enhanc fetal cell mobil improv outcom brain excitotox challeng post partum mice studi pave way natur stem cell therapi base select recruit fetal progenitor repair matern brain injuri | D001930 | T037 |
36,240,948 | cannabidiol inhibit microglia activ mitig neuron damag induc kainat vitro seizur model epilepsi one common brain disord despit possibl use sever therapeut option mani patient continu seizur entir lifespan need new therapeut approach last year interest non psychoact compound present cannabi sativa massiv increas cannabidiol cbd shown effect treatment differ type neurolog disord neurodegen diseas epilepsi ischemia multipl sclerosi alzheim diseas | D002185;D004827 | T121;T047;T109;T033 |
36,240,912 | gw new allel gw improv grain weight grain yield rice grain weight import characterist grain shape key contribut factor grain yield rice report gw new allel grain width weight gw gene regul grain size grain weight singl nucleotid substitut code sequenc cds gw result chang glutam lysin ek gw protein complement test gw overexpress experi demonstr missens mutat gw respons phenotyp enlarg grain size mutant line jf larg grain trait near isogen line nil gw found result increas cell prolifer flower develop meanwhil nil gw shown increas grain yield without compromis grain qualiti gw protein local cell nucleus membran interact chb subunit chromatin remodel complex final f hybrid cross nil gw cytoplasm male steril line exhibit larg grain desir grain appear thus gw promis allel could appli improv grain yield grain appear rice avail data materi dataset generat andor analyz studi avail correspond author reason request | D012275 | T168;T002 |
36,240,910 | mdco interact rna polymeras ii transcript subunit regul dwarf growth short internod columnar appl domin co locus control columnar growth phenotyp appl malus domestica tree candid gene mdco encod oxoglutar depend dioxygenas caus dwarf growth short internod transgen plant reduc abund biolog activ gibberellin howev pathway regul mdco dwarfism appl tree remain unclear studi express mdco prove negat correl internod length f popul creat cross columnar parent dwarfism transgen appl plantlet yeast saccharomyc cerevisia two hybrid screen identifi rna polymeras ii transcript subunit mdmed putat interactor mdco bimolecular fluoresc complement co immunoprecipit dual luciferas report assay confirm interact vivo vitro ectop express mdmed nicotiana tabacum led dwarf phenotyp similar mdco transgen appl plant express gaox gaox encod key enzym gibberellin metabol upregul transgen plant transient transcript activ demonstr mdmed function activ promot express mdgaox mdgaox find indic interact mdco mdmed function regul internod length columnar appl | D027845;D004392 | T168;T019;T002 |
36,240,908 | lysin specif demethylas primari sensori neuron particip chronic compress dorsal root ganglion induc neuropath pain low back radicular pain syndrom usual caus local inflamm irrit nerv root dorsal root ganglion drg common throughout medic practic suffici pain relief scarc studi employ chronic compress drg ccd induc radicular pain model rat explor whether lysin specif demethylas lsd histon demethylas transcript co repressor involv patholog process radicular pain found lsd express various size drg neuron immunohistochemistri ccd induc upregul lsd compress l l drgs moreov either lsd small interf rnas lsd inhibitor attenu ccd induc pain hypersensit lsd also upregul injur lumbar l drg spinal nerv ligat snl induc neuropath pain mous model nevertheless lsd alter l l drgs complet freund adjuv induc inflammatori pain mous model paclitaxel streptozotocin induc neuropath pain model furthermor knockdown lsd injur l drg revers snl induc pain hypersensit mice therefor specul nerv injuri induc upregul lsd injur drgs contribut neuropath pain hypersensit thus lsd may serv potenti target treatment radicular pain neuropath pain | D009437;D006967 | T046;T047;T184 |
36,240,907 | interact effect intracerebroventricular inject crocin adrenoceptor memori deficit hippocamp synapt plastic follow chronic pain rat patient chronic pain exhibit anxieti deficit memori addit adrenoceptor wild express brain import role modul pain memori format present studi investig interact effect crocin central adrenoceptor pain comorbid hippocamp synapt plastic chang follow chronic constrict injuri cci sciatic nerv rat drug crocin antagonist yohimbin agonist clonidin adrenerg receptor inject via intracerebroventricular inject day cci oper day continu daili per day th day post cci effect drug cold allodynia use aceton test anxieti like behavior use elev plus maze epm open field test assess spatial memori use barn maze assess day post cci oper hippocamp synapt plastic use vivo extracellular field potenti record perform day post cci oper observ crocin induc analges anxiolyt memori enhanc action follow cci surgeri furthermor crocin signific increas long term potenti ltp increas fepsp slope popul spike amplitud furthermor co inject yohimbin effect decreas analges anxiolyt enhanc action crocin ltp paramet fepsp slope popul spike amplitud studi provid inform protect effect crocin painanxieti respons synapt plastic possibl mediat central adrenoceptor rat chronic pain | D059350;D014151 | T121;T047;T184;T039 |
36,240,896 | potenti use kraft lignin natur ingredi cosmet evalu photoprotect activ skin irrit potenti cosmet market recent undergon chang consum increas seek sustain product context agro deriv lignin potenti cosmet applic thus studi investig photoprotect activ skin irrit potenti oecd tg skinvitro rhe hous reconstruct human epidermi rhe model kraft lignin le two le deriv lignin modifi enzymat reaction achiev higher molecular weight mw r intermedi mw e highest mw result show le r lignin present adequ photoprotect activ averag sun protect factor spf respect e also present adequ spf howev due poor solubl lignin potenti applic physic filter term safeti lignin caus skin irrit cellular structur damag epidermi addit use analysi base autofluoresc featur lignin sign test lignin found expos rhe model indic three lignin penetr skin altogeth result indic promis applic kraft lignin sunscreen product regard safer altern product sustain also skinvitro rhe show good model evalu skin irrit potenti substanc includ natur cosmet ingredi | D008031;D003358 | T073;T109;T123;T167 |
36,240,895 | chitosanhpmc base mucoadhes film co load fluconazol ofloxacin manag polymicrobi kerat bacteri fungal co infect lead polymicrobi kerat pmk current studi produc swellabl mucoadhes biopolymer film compos chitosan hpmc glycerol use cast dri method film dual load fluconazol fcz ofloxacin ofx treat pmk prepar film exhibit excel thick fold endur surfac ph tensil strength stabil characterist addit also exhibit good vitro antimicrobi activ ex vivo mucoadhes corneal permeat auc mrt fold higher film contain fcz fold higher film contain ofx market formul pk pd simul studi support desir efficaci propos dosag form thus film exhibit longer pre corneal drug resid time enhanc ocular bioavail like result high patient complianc propos film could promin replac exist dosag form may present viabl altern treatment pmk | D048271;D007634 | T121;T047;T109 |
36,240,894 | curcumin encapsul self assembl nanoparticl base amphiphil palmit acid graft quatern chitosan enhanc cytotox antimicrobi antioxid properti practic applic curcumin cur great limit due instabl high hydrophob low bioavail inabl cross mucos barrier gastrointestin tract overcom disadvantag sever deliveri system explor formul cur oral administr nanoparticl nps signific enhanc oral absorpt bioavail therapeut efficaci drug howev nps limit gastrointestin degrad mucos epitheli barrier novel amphiphil quaternari ammonium chitosan n hacc base np deliveri carrier prepar use palmit acid pa encapsul cur palmitoyl chitosan pa n hacc character includ ft ir h nmr tga cac particl size pa n hacc nps pa n hacc nps load cur cur pa n hacc nps nm nm encapsul effici load capac cur pa n hacc nps cur pa n hacc nps exhibit sustain control releas compar cur minimum inhibitori concentr cur pa n hacc nps escherichia coli staphylococcus aureus candida albican reduc time time time respect moreov antioxid activ cur pa n hacc nps dose depend higher free cur pa n hacc nps show littl toxic promis deliveri system encapsul hydrophob drug | D048271;D003474;D053758;D000890 | T121;T109;T073;T130 |
36,240,893 | skin adapt film dress smart releas growth factor acceler diabet wound heal general treatment diabet wound use wound dress absorb excess exud howev tradit wound dress neither mimic skin like properti easili withdrawn wound herein skin adapt three layer film agb dress design altern deposit phenylboron acid graft pga pba pga polyvinyl alcohol pva thick agb film flexibl obvious strengthen boron ester cross link besid dri agb film conveni adher fresh wound adhes forc reach mn moreov adher agb film easili peel without second damag hydrat anti inflammatori tripeptid kpv epiderm growth factor egf biolog factor respect encapsul bottom layer middl top two layer agb film kpv first releas within day egf subsequ releas glucos respons manner agb film contain kpv egf k e agb could signific improv repair rate full thick skin wound diabet mice mechan wound heal associ inflammatori inhibit angiogenesi collagen deposit collect skin adapt film may promis dress deliveri biolog factor chronic wound | D004815;D003921 | T121;T050;T116;T125 |
36,240,892 | possibl function proxim various organ base bioinformat analysi tast receptor tast one essenti sens provid organ faith represent extern world tast percept respons basic food drink apprais bestow organ valuabl discriminatori power umami sweet good tast promot consumpt nutrit food wherea bitter sour bad tast alert organ toxin low ph promot reject food contain harm substanc everi anim sens tast human variat tast receptor gene contribut inter intra organ differ tast sweetbitt sensat prefer therefor deeper understand need comprehend tast percept various vertebr accord elucid possibl proxim among studi total type sweet type bitter tast receptor complet amino acid sequenc taken vertebr organ mammalian ave amphibian among primat includ human close base genom tast receptor rodent organ viz rat mous away investig throw light similitud dissimilitud percept sweet bitter tast among differ organ steer quantit analysi genom data furthermor enlighten ligand bind affin sweetbitt tast molecul tast receptor proxim pair organ would similar | D013649;D013650 | T023;T042 |
36,240,891 | novel bifunct protein pnu caco polymorph format vaterit stabil surfac energi minim caco occur three crystallin anhydr polymorph name calcit aragonit vaterit alway found miner skeleton grow shell mani marin organ howev understand organ achiev control signific challeng biominer work propos novel vaterit stabil acid matrix protein pnu exist prism nacr pinctada fucata identifi function domain ddddddhddveet experi reveal pnu trigger stabl larg vaterit format mg defici even low ca increas pnu calcium carbon crystal system mg lead signific shrink crystal size rise nucleat quantiti moreov convert atom rough dome like shape smooth sphere unsilicon glass effect rescind remov asp rich region c terminus also find decreas pnu mrna vivo lead nacreous inner surfac growth substanti lessen thus pnu may suppli vaterit shell format also involv nacreous regul via surfac energi minim | D060734;D049911 | T109;T204 |
36,240,890 | ultra low protein residu chitosan one step h sodium dodecyl sulfat treatment residu protein chitosan base biomateri may caus inflamm allergi immun reject surgeri imped clinic applic facil product chitosan ultra low protein content residu protein yet address herein propos one step method prepar chitosan residu protein content use hydrogen peroxid sodium dodecyl sulfat simpl time save cost effect acidalkali free notabl molecular weight chitosan reduc simultan effect experiment paramet ie hydrogen peroxid concentr sds concentr reaction temperatur c c protein remov molecular weight decreas systemat analyz respons surfac methodolog result show temperatur h concentr main paramet affect deprotein chitosan character result ultra low protein residu chitosan reveal unchang chemic structur enhanc crystallin reduc thermal stabil propos one step deprotein method may great potenti industri mass product ultra low protein residu chitosan | D048271 | T121;T109 |
36,240,889 | prepar character light color lignin corn stover new ternari deep eutect solvent extract industri lignin shown great potenti replac petrochem deep color lignin limit applic high valu field extract light color lignin lignocellulos still remain challeng report strategi rapid extract lignin corn stover use new ternari deep eutect solvent tdes compos cholin chlorid chcl formic acid fa maleic acid color featur structur character obtain lignin comprehens elucid result reveal lignin stream light color bright iso high yield puriti low molecular weight mw gmol low polydispers pdi introduct could reduc destruct lignin substructur treatment process avoid deepen lignin color quantit analysi conjug carbonyl quinon carbonyl semi quantit analysi lignin nmr show temperatur great influenc structur | D008031;D003313 | T002;T109;T123;T168 |
36,240,888 | advanc role natur gum base hydrogel water purif desalin atmospher water harvest freshwat scarciti one world foremost environment stress concern last year sustain industri growth rapid grow popul problem freshwat shortag encourag research conduct comprehens research develop advanc water harvest wastewat treatment techniqu natur gum base hydrogel wide use differ water purif harvest applic environ friend natur high water absorpt adsorpt retent capac articl present entir conceptu critic review literatur main focus potenti differ natur gum base hydrogel water harvest wastewat treatment applic first differ categori natur gum base hydrogel includ stimuli respons hydrogel physic chemic crosslink hydrogel introduc emphasi given role natur gum base hydrogel differ wastewat treatment applic like adsorpt photocatalysi floccul latest research progress use natur gum base hydrogel atmospher water harvest seawat desalin discuss final differ challeng main limit associ use natur gum hydrogel water purif harvest applic discuss understand research gap drawback need improv | D020100;D018508 | T057;T122;T052 |
36,240,887 | guar gum chitosan base composit edibl coat extend shelf life preserv bioactiv compound store kinnow fruit present investig aim elucid effect chitosan ch guar gum gg base composit edibl coat physicochem qualiti storabl kinnow fruit ambient condit composit coat materi prepar use tamarind tam seed starch jackfruit jack seed starch ch gg separ result indic gg tam coat fruit maintain signific p lower physiolog loss weight plw decay incid respir rate ml co kg h compar control reduc activ pectin methylesteras pme mol min g fw lipoxygenas lox mol min g fw note gg tam coat fruit also gg tam coat fruit retain higher fruit firm n titrat acid ta ascorb acid aa mg g total phenol mg gae g fw antioxid activ mol te g along higher sensori score control base find conclud gg tam coat could gain util prolong shelf life kinnow fruit day without lose desir qualiti trait ambient storag | D048271;D000080122 | T121;T109;T073 |
36,240,886 | molecular interplay promot amelior quercetin experiment hepat inflamm rodent protein modul process chang protein structur either deriv deliber induc lead variat protein activ protein protein interact util understand diseas mechan develop novel therapeut context cox ino gst along basic liver biochemistri examin experiment injur rat quercetin qc supplement diethylnitrosamin mlkgbwt den use generat liver injuri anim quercetin administ mgkgbwt daili den treat anim investig effect hepat astaltalpgt bilirubin glycogen lpo cat sod gst collagen level protein oxid nitrit examin anim besid histopatholog immunohistochemistri cox ino perform tissu section molecular dock quercetin human cox ino gst perform autodock softwar drug likeli properti ligand swiss adm admetsar molinspir respect result demonstr disturb primari liver function concomit disconcert liver biochemistri anatomi den treat anim p immunohistochemistri exhibit regul cox ino liver injuri molecular dock show quercetin accept drug pass lipinski rule show bind gst ino cox conclus cox ino gst appear dynam molecular target quercetin action restor tissu biochemistri anatomi experiment liver injuri | D011794;D000975 | T121;T109;T127;T123;T044;T039 |
36,240,885 | facil prepar novel hyaluron acid modifi metal polyphenol phototherm nanoformul tumor therapi phototherm therapi ptt potenti effect non invas tumor therapi attract attent mani research studi systemat investig format metal polyphenol nanoparticl phototherm properti simpl physic self assembl method use emb hyaluron acid ha metal polyphenol nanoparticl novel type ha modifi ferrous baicalein nanoparticl hfbnp success prepar first time unlik current method util posit negat charg attract chemic bond method propos studi emb ha nanostructur reduc risk ha shed circul therebi improv tumor target effici avoid use chemic reagent hfbnp suitabl size distribut good biosafeti meanwhil effici convert near infrar nir laser energi thermal energi activ target capabl mediat ha signific increas uptak nanoparticl tumor cell hfbnp exhibit strong growth inhibitori effect tumor cell nir laser irradi combin ptt chemotherapi hfbnp signific inhibit tumor growth tumor bear mice conclus nanosystem prepar studi provid new strategi tumor therapi | D053758;D053768;D009369;D049329 | T191;T073 |
36,240,875 | mechan under retino acid depend metamorphosi starfish evolut biphas life cycl marin invertebr attract consider interest zoolog recent provid evid retino acid ra involv regul metamorphosi starfish also function life cycl transit jellyfish cnidaria thus document evolutionarili conserv role ra transit help trace life cycl evolut bilaterian cnidarian studi examin molecular mechan ra signal involv commenc metamorphosi starfish first measur ra level larval metamorphosi stage liquid chromatographi tandem mass spectrometri found tran ra level larval bodi high larva acquir compet metamorphosi suggest commenc metamorphosi control increas ra synthesi furthermor suppress rar gene express talen mediat gene knockout reveal ra receptor rar essenti metamorphosi observ suggest initi metamorphosi regul level synthes ra activ rar discuss diverg ligand molecul receptor evolut life cycl regul | D014212;D013215 | T121;T109;T131;T204 |
36,240,874 | preval prognosi hard heal wound comorbid china regular retrospect analysi necessari potenti improv clinic practic treatment hard heal wound comorbid outcom demonstr spatial tempor divers emphasis import updat epidemiolog complex heal hard heal wound long known sought evid base improv current principl treatment | D010243;D014945 | T184;T040;T033 |
36,240,873 | express nucleolin nucleophosmin upstream bind transcript factor gene propoli wound model nucleolar protein import function regul cell homeostasi play crucial role sens various type stress genotox stress propoli epitheli analges antibacteri antifung antivir effect studi aim evalu gene express level nucleolar protein nucleolin ncl nucleophosmin npm upstream bind transcript factor ubtf well benefit propoli wound heal | D011429 | T121;T123 |
36,240,871 | determin effect dorema ammoniacum gum wound heal experiment studi long time natur compound use acceler wound heal studi topic effect ammoniacum gum extract wound heal investig white male rat | D010672;D042461 | T121;T109;T123;T116 |
36,240,870 | combin applic moist expos burn ointment maggot therapi wound heal hard heal wound global health challeng effect treatment still lack moist expos burn ointment mebo maggot tradit treatment promot wound heal studi preliminari explor combin maggot therapi mebo treatment hard heal wound | D012855;D014945 | T121;T109;T040 |
36,240,865 | fibroblast growth factor dietari macronutri intak femal mice fibroblast growth factor fgf metabol stress hormon releas liver respons various nutrit challeng notabl effect improv metabol health includ bodi fat loss glucos control hepatosteatosi sever pharmaceut analog fgf develop treatment metabol diseas addit small develop literatur clear demonstr fgf also control feed behavior pharmacolog administr fgf reduc consumpt simpl sugar sweet tastant increas consumpt dietari protein male suggest anoth potenti mechan fgf treatment could improv metabol health promot healthi eat despit sex key biolog variabl influenc feed behavior macronutri select current literatur date primarili male studi investig effect fgf sucros intak macronutri select femal mice similar previous find male mice report fgf administr decreas consumpt sucros solut femal offset increas chow intak also agreement previous find male report fgf increas consumpt dietari protein femal mice offset either reduc carbohydr reduc fat intak last find effect fgf direct macronutri intak femal depend action neuron overal data support role fgf direct macronutri intak similar manner femal male mice | D005346;D004435 | T116;T038;T123;T040;T033 |
36,240,864 | astaxanthin amelior impair consequ prenat bacteri lipopolysaccharid exposur adult male offspr nmri mice studi potenti effect astaxanthin ast investig prevent prenat lps induc injur mother adult male offspr nmri mice pregnant mice random divid four group salin vehicl salin ast receiv astaxanthin mgkg day ip gestat day lps vehicl lps treat group inject lps gkg sc gestat day lps ast administr lps astaxanthin gestat day respect group matern care behavior tnf serum level examin wean male offspr day day old male pup underw analysi bodi weight length serum gonadotropin testosteron hormon level sperm qualiti gonad brain tissu morpholog express sox gnrh gene real time pcr serum tnf level increas signific mother treat lps ast reduc adult male offspr serum hormon level sperm qualiti number spermatocyt leydig cell test improv ast administr accord histolog studi brain neuron lps treat group smaller less activ wherea neuron lps ast group larger numer activ lps signific reduc gnrh express ast induct improv express ast administr pregnanc prevent advers effect prenat exposur lps presum genom non genom effect adult male offspr | D008070;D011297 | T109;T037 |
36,240,863 | synergist action organophosph covid inflamm oxid stress renin angiotensin system amplifi risk cardiovascular maladi organophosph op ubiquit environment contamin wide use pesticid agricultur field addit serv flame retard plastic antifoam antiwear agent lacquer hydraul fluid floor polish agent therefor world wide massiv applic compound increas risk unintent exposur non target includ human be op neurotox agent inhibit activ acetylcholinesteras synapt cleft moreov fuel cardiovascular issu form myocard cardiac oedema arrhythmia systol malfunct infarct alter electrophysiolog patholog outcom might increas sever cardiovascular diseas lead caus mortal develop world coronavirus diseas covid ongo global health emerg caus sar cov infect similar op sar cov disrupt cytokin homeostasi redox balanc angiotensin iiat r axi promot cardiovascular injuri therefor current pandem milieu unintent exposur op sever environment sourc could escal cardiac maladi patient covid | D000086382;D002318 | T047;T067 |
36,240,855 | clinic evid heterogen impact treatment select case studi abirateron metastat prostat cancer two pivot random control trial rcts demonstr abirateron acet prednison aap combin androgen depriv therapi adt signific extend surviv men metastat hormon sensit prostat cancer mhspc compar adt alon subgroup analys indic surviv benefit signific younger men older men aim assess whether public rcts associ differenti real world aap util age group | D000069501;D011471 | T121;T109;T191 |
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