PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,240,854 | optim neoadjuv strategi local advanc rectal cancer risk assess tumor locat neoadjuv therapi standard care local advanc rectal cancer larc advanc multimod therapi option sequenc radiat therapi rt surgeri chemotherapi make decis make challeng tradit treatment patient larc involv neoadjuv chemoradi follow total mesorect excis consider adjuv chemotherapi advanc rt led trial offer short cours long cours rt good long term clinic outcom intensif therapi high risk patient led studi total neoadjuv therapi chemotherapi chemoradi standard manag larc de escal therapi patient favor prognosi led sever consider includ non total mesorect excis manag neoadjuv chemotherapi sever consider patient diseas factor help inform optim chemotherapi regimen differ sequenc neoadjuv strategi final novel biomark microsatellit instabl led util novel therapi includ neoadjuv immunotherapi substanti respons review attempt frame rapid grow data larc context diseas patient risk factor inform optim person treatment patient larc | D016609;D012004 | T191 |
36,240,852 | diagnosi manag rectal cancer patient younger year rise global incid uniqu challeng global incid colorect adenocarcinoma stabl decreas overal howev incid colorect cancer patient age year increas although increas due hereditari cancer syndrom sole explan patient earli onset rectal cancer particular uniqu diseas pattern face distinct challeng treatment molecular pattern diseas patient cohort noteworthi often repres opportun target cancer effect recent ongo trial focus minim toxic necessari therapi modal maxim respons patient outcom paramount import patient popul addit resourc need patient popul includ fertil counsel preserv financi guidanc genet counsel psychosoci support | D000230;D015179;D012004 | T191 |
36,240,850 | rectal cancer version nccn clinic practic guidelin oncolog select nccn guidelin rectal cancer focus manag malign polyp resect nonmetastat rectal cancer import updat made guidelin recent updat includ redraw algorithm stage ii iii diseas reflect new data support increas promin role total neoadjuv therapi expand recommend short cours radiat therapi techniqu new recommend watch wait nonop manag techniqu patient cancer show complet respons neoadjuv therapi complet version nccn guidelin rectal cancer avail onlin nccnorg cover addit topic includ risk assess patholog stage manag metastat diseas posttreat surveil treatment recurr diseas survivorship | D012004 | T191 |
36,240,849 | except respons erdafitinib fgfr mutat metastat pancreat ductal adenocarcinoma despit advanc cancer therapeut pancreat ductal adenocarcinoma pdac remain among deadliest malign poor prognosi time diagnosi research pdac suggest adapt signal tumor microenviron may promot tumor prolifer surviv sever fgfr fusion gene specif fgfr involv creation progress cancer mutat found varieti cancer type report present uniqu case young patient stage iv pdac known fgfr fusion molecular alter afford remark respons fgfr inhibitor therapi erdafitinib patient experienc diseas progress multipl chemotherapi regimen | D000230;D021441;D010190 | T191 |
36,240,848 | patient caregiv oncologist experi percept racial bias discrimin cancer care deliveri cancer prevent treatment system signific impact interperson organiz structur system racism wide bodi research found racial dispar access guidelin adher cancer care pervas throughout unit state contribut factor includ social determin health insur status bias discrimin care deliveri although exist racial dispar cancer care outcom well establish limit research explor patient caregiv experi bias discrimin cancer care | D009369;D000072103;D063505 | T191;T054;T097 |
36,240,847 | nccn guidelin insight survivorship version nccn guidelin survivorship intend help healthcar profession work survivor ensur survivor complex vari need address nccn guidelin provid screen evalu treatment recommend consequ adult onset cancer treatment recommend help promot physic activ weight manag immun survivor framework care coordin articl summar updat nccn guidelin pertain prevent health cancer survivor includ recommend alcohol consumpt vaccin | D000073116;D009369 | T191;T101;T201 |
36,240,846 | oral chemotherapi metric perform qualiti oncolog practic initi practic updat trend analysi oral chemotherapi perform measur first introduc asco qualiti oncolog practic initi qopi studi examin perform measur among qopi particip practic evalu whether differ among practic base meet qopi certif program standard | D002568;D008495 | T091;T064;T081 |
36,240,845 | immun relat advers event among covid vaccin patient cancer receiv immun checkpoint blockad whether covid vaccin associ immun respons increas suscept immun relat advers event ira among patient treat immun checkpoint inhibit ici remain unknown short term follow assess safeti concurr administr vaccin ici treatment | D000086382;D009369 | T191;T047;T067 |
36,240,844 | relationship longitudin cope strategi outcom patient acut myeloid leukemia patient acut myeloid leukemia aml face abrupt life threaten ill experi immens physic psycholog symptom howev data describ patient aml cope longitudin ill relationship longitudin cope outcom | D015470;D011788 | T191;T078 |
36,240,841 | incid cardiovascular diseas among survivor high risk stage ii iii colorect cancer cluster wide cohort studi incid surviv colorect cancer crc increas increas number long term survivor mani elder comorbid conduct popul base studi hong kong assess long term cardiovascular diseas cvd incid associ adjuv fluoropyrimidin base chemotherapi among crc survivor | D002318;D015179 | T191;T047 |
36,240,838 | cardiovascular outcom adult hypertens even versus morn dose usual antihypertens uk time studi prospect randomis open label blind endpoint clinic trial studi suggest even dose antihypertens therapi might better outcom morn dose treatment morn versus even time studi aim investig whether even dose usual antihypertens medic improv major cardiovascular outcom compar morn dose patient hypertens | D006973;D009203 | T047 |
36,240,834 | develop tuberculosi vaccin peopl hiv consensus statement intern expert panel new tuberculosi vaccin candid develop pipelin need studi peopl hiv high risk acquir mycobacterium tuberculosi infect tuberculosi diseas tend develop less robust vaccin induc immun respons address gap develop tuberculosi vaccin peopl hiv seri symposia held pose six frame question panel intern expert use case rational develop tuberculosi vaccin landscap tuberculosi vaccin vaccin candid prioritis tuberculosi vaccin trial design consider role immunolog correl protect gap preclin model studi tuberculosi vaccin intern expert panel formul consensus statement frame question intent inform tuberculosi vaccin develop prioritis clinic trial inclus peopl hiv | D032581;D009169;D015658;D014376 | T121;T007;T047;T129 |
36,240,833 | epidemiolog analysi legionnair diseas scotland genom studi legionella pneumophila main caus sever pneumon ill known legionnair diseas global public health threat whole genom sequenc wgs appli trace environment origin l pneumophila infect provid inform guid appropri intervent aim explor evolutionari epidemiolog relationship year scottish l pneumophila refer isol collect | D007877 | T047 |
36,240,832 | robust evid report preprint peer review scientist express concern risk flaw decis make increas use preprint data might chang undergo peer review health polici paper assess covid evid present preprint chang review quantifi attrit dynam epidemiolog estim first report preprint match subsequ peer review journal public point estim valu chang averag review correl estim valu review high systemat trend expert peer review score preprint qualiti relat eventu public peer review journal uncertainti reduc peer review cis reduc averag result support use preprint compon biomed research literatur decis make result also help inform use preprint ongo covid pandem futur diseas outbreak | D035843;D000086382 | T047;T062;T067 |
36,240,831 | evalu effect measl rubella mass vaccin campaign seropreval india cross section household serosurvey four district india phase measl rubella supplementari immunis activ mr sia ie mass immunis campaign target children age month less year estim measl rubella seropreval mr sia quantifi effect popul immun identifi remain immun gap | D008457;D012409 | T047 |
36,240,830 | evalu health impact cost effect tuberculosi prevent treatment modern hiv cohort antiretrovir therapi model analysi use data tanzania isoniazid prevent therapi ipt prevent tuberculosi among peopl receiv antiretrovir therapi art hiv programm initi patient art higher averag cd cell count lower tuberculosi risk test treat guidelin aim investig chang affect health impact cost effect ipt | D015658;D014376 | T047 |
36,240,829 | state health indonesia provinc systemat analysi global burden diseas studi analys trend level burden diseas nation level mask inequ health relat progress lower administr unit provinc district use result global burden diseas injuri risk factor studi gbd analys health pattern indonesia provinci level long term analys diseas burden provid insight indonesia advanc univers health coverag abil meet unit nation sustain develop goal | D003141;D000073296 | T047 |
36,240,828 | predict upcom global infect burden influenza season relax public health social measur covid pandem model studi transmiss dynam influenza affect public health social measur phsms implement global sinc earli mitig covid pandem aim assess effect covid phsms transmiss influenza virus predict upcom influenza epidem | D000086382;D007251 | T047;T067 |
36,240,827 | evalu mitig potenti indirect effect covid control programm seven neglect tropic diseas model studi line movement restrict physic distanc essenti control covid pandem recommend postpon neglect tropic diseas ntd control activ involv communiti base survey activ case find mass drug administr april follow revis guidanc later interrupt ntd programm vari length ntd programm gradual restart context ongo pandem howev ongo challeng servic gap report studi aim evalu potenti effect programmat interrupt strategi mitig effect | D000086382;D007898;D009855;D012552;D014141;D014330 | T047;T091;T067 |
36,240,826 | micronutri defici among preschool age children women reproduct age worldwid pool analysi individu level data popul repres survey micronutri defici compromis immun system hinder child growth develop affect human potenti worldwid yet knowledg exist estim global preval micronutri defici year ago base preval anaemia aim estim global region preval defici least one three micronutri among preschool age children age month non pregnant women reproduct age age year | D018798;D044342 | T047 |
36,240,825 | women risk death beyond day post partum pool analysi longitudin health demograph surveil system data sub saharan africa standard definit pregnanc relat matern death includ death occur within day deliveri termin abort major implic post partum care matern mortal surveil therefor estim post partum surviv childbirth year post partum evalu empir justif day post partum threshold | D063130;D008428 | T081;T040 |
36,240,824 | caus preterm neonat death india pakistan purpos prospect cohort studi preterm birth remain major caus neonat death worldwid south asia contribut disproportion death among preterm birth worldwid yet popul base studi assess under caus death novel evalu includ histolog bacteriolog assess placent fetal tissu facilit precis determin under caus preterm death sought assess under contribut caus preterm neonat death india pakistan | D003141;D066087;D047928 | T047;T046;T033 |
36,240,805 | treatment relat thorac soft tissu sarcoma us breast cancer survivor retrospect cohort studi soft tissu sarcoma rare serious side effect radiotherapi treat breast cancer rate increas usa evalu potenti co factor two complimentari cohort us breast cancer survivor | D001943;D000073116;D006394;D016609;D012509;D012983;D006973 | T191;T101;T047;T201 |
36,240,800 | desicc compound biofilm necrosi remov agent case seri new compound debrichem debx medic bv netherland topic desicc agent tda activ gel contain acid speci potent hygroscop action contact microorgan necrosi rapid desicc carbonis protein microorgan well extracellular matrix biofilm necrosi occur result precipit rapid dislodg wound bed result clean wound granul prerequisit heal secondari intent | D017719;D014647 | T047 |
36,240,799 | evalu nurs opinion percept maggot therapi hard heal wound manag maggot therapi mt larval debrid therapi recognis effect underutilis treatment manag hard heal wound infect ulcer avail nhs prescript uk wound manag predomin nurs led anecdot report publish literatur suggest nurs may reluct utilis therapi aim studi evalu feel opinion nurs regard use mt | D062109;D014945 | T061;T040 |
36,240,798 | use acellular intact fish skin graft treat acut paediatr wound covid pandem case seri specif strategi need support children requir skin graft goal identifi procedur reduc oper time post oper complic pain length hospit stay patient safeti optim wound bed support quick micro debrid locoregion anaesthesia prioritis ultim novel acellular fish skin graft fsg deriv north atlant cod select use | D000086382;D054843 | T061;T047;T074;T067 |
36,240,796 | burden inform caregiv patient pressur ulcer primari care set aim studi assess burden experienc caregiv patient pressur ulcer pus variabl might contribut manifest | D017028;D003668 | T098;T047;T097;T099 |
36,240,795 | effect photomodul fibroblast growth factor rasmapk signal pathway review current therapi technolog use treat hard heal diabet wound limit heal rate rise percentag lower limb non traumat amput patient diabet caus increas demand altern effect safe treatment modal photobiomodul therapi pbmt utilis light induc physiolog chang provid therapeut benefit shown increas heal hard heal wound releas growth factor aim narrat review investig effect photobiomodul pbm fibroblast growth factor fgf role rasmapk signal pathway diabet wound heal | D003921;D028022 | T050;T061 |
36,240,794 | impair wound heal diabet impair wound heal patient diabet due constel structur biochem cellular microbi factor hyperglycaemia associ inflamm contribut immun dysfunct vascular damag neuropathi cellular senesc impair transit beyond inflammatori stage microbiom disrupt fail extracellular matrix format growth factor cytokin imbal limit epithelialis alter fibroblast migrat prolifer optimis glycaem control remain primari intervent prevent continu dysfunct comorbid diseas progress | D003920;D017719 | T047 |
36,240,793 | age decreas heal wound skin alcohol prefer rat alcohol consumpt combin age alter heal process skin evalu whether age decreas heal incision wound skin wistar rat universidad de chile varieti b uchb | D019098;D042461 | T126;T116;T123 |
36,240,792 | pyoderma gangrenosum dehydr human amnionchorion membran potenti tool orphan diseas pyoderma gangrenosum pg often misdiagnos pain inflammatori ulcer skin disord orphan diseas standard wound treatment sharp surgic debrid contraind retrospect case seri sought evalu applic dehydr human amnionchorion membran dhacm skin substitut case refractori rang standard care techniqu | D002823;D017511 | T018;T047 |
36,240,787 | aedeomyia aedeomyia squamipenni new genus speci counti record monro counti florida usa aedeomyia aedeomyia squamipenni tropic mosquito recent observ usa natur rang central south america expand sever caribbean island mainland florida recent year found florida key despit associ gamboa virus avian malaria concern establish vectori capac diminish florida key due ae squamipenni lack prefer larval habitat | D009033 | T204 |
36,240,781 | gut innerv nociceptor regul intestin microbiota promot tissu protect nocicept pain hallmark mani chronic inflammatori condit includ inflammatori bowel diseas ibd howev whether pain sens neuron influenc intestin inflamm remain poor defin employ chemogenet silenc adenovir mediat colon specif silenc pharmacolog ablat trpv nociceptor observ sever inflamm defect tissu protect repar process murin model intestin damag inflamm disrupt nocicept led signific alter intestin microbiota transmiss dysbiosi mono colon germ free mice gram clostridium spp promot intestin tissu protect nociceptor depend pathway mechanist disrupt nocicept result decreas level substanc p therapeut deliveri substanc p promot tissu protect effect exert trpv nociceptor microbiota depend manner final dysregul nociceptor gene express observ intestin biopsi ibd patient collect find indic evolutionarili conserv function link nocicept intestin microbiota restor intestin homeostasi | D000069196;D015212 | T007;T001;T047 |
36,240,780 | en mass organoid phenotyp inform metabol associ genet suscept nash genotyp phenotyp associ common diseas often compound pleiotropi metabol state devis pool human organoid panel steatohepat investig impact metabol status genotyp phenotyp associ en mass popul base phenotyp analysi insulin insensit condit predict key non alcohol steatohepat nash genet factor includ glucokinas regulatori protein gckr rs c analysi nash clinic cohort reveal gckr rs allel elev diseas sever diabet state protect fibrosi non diabet state transcriptom metabolom pharmacolog analys indic signific mitochondri dysfunct incur gckr rs revers metformin uncoupl oxid mechan mitig mitochondri dysfunct permit adapt increas fatti acid suppli protect oxid stress form basi futur therapeut approach diabet nash thus dish genotyp phenotyp associ strategi disentangl oppos role metabol associ gene variant function offer rich mechanist diagnost therapeut infer toolbox toward precis hepatolog video abstract | D020022;D065626 | T047;T032 |
36,240,775 | molecular patholog usher b patient deriv retin organoid singl cell resolut usher syndrom associ retin pigmentosa rp caus progress retin degener cure pathomechan usher type b ushb rp caus myoa mutat remain elus lack faith anim model limit knowledg myoa function analyz retin organoid generat ushb patient deriv induc pluripot stem cell increas differenti gene express occur time without excess photoreceptor cell death ushb organoid compar control dysregul gene enrich first mitochondri function proteasom ubiquitin depend protein catabol process rna splice singl cell rna sequenc reveal myoa express rod photoreceptor mller glial cell correspond upregul stress respons nrl rod apoptot signal pathway vim mller cell point defens mechan mitig photoreceptor cell death first human model ushb rp provid represent patient retina vivo relev develop therapeut strategi | D009940;D012174 | T047;T024 |
36,240,774 | mesenchym stem cell transplant improv biomechan properti vagin tissu follow full thick incis age rat pelvic organ prolaps pop common among post menopaus women associ bladder bowel sexual dysfunct surgic repair patient nativ tissu sub optim high reoper rate potenti due diminish age relat heal demonstr system transplant mesenchym stem cell mscs improv heal full thick vagin incis vagin wall old rat suggest histolog function analysi transplant mscs home surviv surgic vagin site attenu injuri induc inflammatori respons increas angiogenesi reduc matrix metalloproteinas express observ surgic site transplant rat import function biomechan properti heal vagina day post injuri improv msc transplant compar sham oper non transplant old rat result may pave way translat studi toward clinic transplant mscs adjuv pop repair improv surgic outcom | D045164;D056887;D059630 | T061;T047;T025;T020 |
36,240,773 | nanobodi target lexa autocleavag disclos novel suppress strategi sos respons pathway antimicrobi resist threaten erad infecti diseas impair efficaci avail therapeut bacteri sos pathway conserv respons trigger genotox stress repres one princip mechan lead resist reca recombinas act dna damag sensor induc autoproteolysi transcript repressor lexa therebi derepress sos gene mediat dna repair surviv chemotherapi hypermut inhibit pathway repres promis strategi delay evolut antimicrobi resist report identif via llama immun phage display nanobodi bind lexa sub micromolar affin block autoproteolysi repress sos respons escherichia coli biophys character nanobodi lexa complex reveal act trap lexa inact conform interf reca engag studi pave way develop new generat antibiot adjuv treatment bacteri infect | D013014;D061905 | T045;T116;T129 |
36,240,765 | construct cross popul polygen risk score use transfer learn exist genom wide associ studi gwass conduct european ancestri cohort exist polygen risk score prs model limit transfer across ancestri group prs research non european ancestri group need make effici use avail data attain larg sampl size across ancestri group propos prs method use transfer learn techniqu approach tl prs use gradient descent fine tune baselin prs model ancestri group larg sampl gwass dataset target ancestri applic construct prs seven quantit two dichotom trait individu south asian ancestri individu african ancestri uk biobank tl prs use prs cs baselin method obtain averag relat improv south asian sampl african sampl compar standard prs cs method term predict r approach increas transfer prss across ancestri therebi help reduc exist inequ genet research | D055106;D020412 | T045;T063;T032 |
36,240,762 | f flutemetamol petct transthyretin amyloid cardiomyopathi time matter report f flutemetamol petct find year old man cognit impair transthyretin amyloid cardiomyopathi earli phase petct imag show signific increas myocardi uptak myocardi uptak delay phase petct imag dual time point amyloid petct imag may help diagnos differenti subtyp amyloid cardiomyopathi patient suspect cardiac amyloidosi | D000686;D009202 | T047 |
36,240,761 | activ shape model registr ocular structur comput tomographi imag purpos goal work creat activ shape model segment method base statist shape model five region globe comput tomographi ct scan use method categor normal globe globe injurymethod set normal globe imag ct scan manual segment vitreous caviti len sclera anterior chamber cornea two grader statist shape model creat region activ shape model train use manual segment statist shape model assess use leav one cross valid activ shape model appli set globe open globe injur segment compar normal globe term standard deviat away normalresult activ shape model asm segment compar well ground truth base dice similar coeffici score leav one experi cornea sclera vitreous caviti anterior chamber len preliminari set ct scan patient open globe injuri segment use asm shape region quantifi sclera vitreous caviti statist differ shape normal zone zone globe statist differ normal cornea anterior chamber result consist definit zonal injuri ogiconclus asm result found reproduc accur correl manual segment quantit metric deriv asm globe ogi consist exist medic knowledg term structur deform | D014057;D007908 | T023;T060 |
36,240,759 | befa microbiota secret membran disrupt dissemin pancrea increas cell mass microbiom dysbiosi featur diabet microbi product influenc insulin product poor understood report mechan befa microbiom deriv protein increas prolifer insulin produc cell develop gnotobiot zebrafish mice befa dissemin system multipl anatom rout act direct pancreat islet detail befa atom structur contain lipid bind sylf domain demonstr permeabil synthet liposom bacteri membran befa mutant impair membran disrupt fail expand cell wherea pore form host defens protein reg stimul cell prolifer work demonstr membran permeabil microbiom deriv host defens protein necessari suffici cell expans pancrea develop potenti connect microbiom composit diabet risk | D064307;D003920 | T001;T047;T032;T028 |
36,240,758 | gut peptid regg link small intestin microbiom regul energi balanc glucos level gut function chang composit gut microbiom import compon gut adapt various environ implic various metabol diseas includ obes type diabet mechan microbiota influenc host physiolog remain contenti find diet high ferment fiber inulin vertic sleev gastrectomi increas intestin express circul level anti microbi peptid regg moreov number benefici effect manipul gut function energi balanc glucos regul absent regg knockout mice peripher administr various prepar regg improv glucos toler effect depend putat receptor extl pancrea data suggest regg act within lumen gut hormon link intestin microbiom various aspect host physiolog may leverag novel treatment strategi | D003924;D064307 | T001;T047;T032;T028 |
36,240,757 | develop accur geant quantum molecular dynam model hadron therapi object although heavi ion therapi quantum molecular dynam qmd model one fundament physic model provid accur daughter ion product yield final state still non neglig differ experiment result aim studi improv fragment product water phantom develop accur qmd model geantapproach qmd model develop implement modern skyrm interact paramet set well incorpor ad hoc cluster model initi nuclear state two adjust paramet select signific affect fragment product qmd model radius discrimin cluster nucleon belong nucleus nucleus reaction denot byr squar standard deviat gaussian packet denot byl squar mahalanobi distanc fragment yield angular distribut higher atom number produc fragment employ object function multi object optim moo make possibl compar quantit simul product yield refer experiment data performedmain result moo analysi show qmd model modern skyrm paramet coupl propos cluster model denot skm drastic improv light fragment yield water addit propos model reproduc kinet energi distribut fragment accur optimizedlin skm confirm realist charg radii analysi ground state formationsignific propos framework use moo demonstr use judg superior propos nuclear model optim qmd model expect improv accuraci heavi ion therapi dosimetri | D056004;D063193 | T061;T044;T066 |
36,240,756 | machin learn determin later flow devic result test sar cov infect asymptomat popul rapid antigen test form later flow devic lfds allow test larg popul sever acut respiratori syndrom coronavirus sar cov reduc variabl devic interpret show design test artif intellig ai algorithm base machin learn machin learn ml algorithm train combin artifici hybrid lfds lfd data link quantit real time pcr result particip recruit assist test site atss health care worker undertak self test imag analyz use ml algorithm panel train clinician use resolv discrep total imag return at substudi sensit increas specif self read substudi sensit increas specif ml base classifi lfd result outperform human read assist test site self read | D000086382 | T047;T067 |
36,240,755 | function immun respons sar cov variant concern fourth covid vaccin dose infect patient blood cancer patient blood cancer continu greater risk inadequ immun respons follow three covid vaccin dose risk sever covid diseas context captur studi nct report immun respons patient blood cancer receiv fourth dose bntb measur neutral antibodi titer nabt use live virus microneutr assay wild type wt delta omicron ba ba cell respons wt omicron ba use activ induc marker aim assay proport patient detect nab titer cell respons fourth vaccin dose increas compar third vaccin dose patient receiv b cell deplet therapi within month vaccin greatest risk detect nabt addit report immun respons patient breakthrough infect vaccin | D000086382;D000086663;D009369 | T191;T047;T200;T067 |
36,240,742 | comparison implant middl ear microphon convent extern microphon cochlear implant clinic feasibl studi commerci avail cochlear implant ci system use extern microphon sound processor howev extern equip carri lifestyl limit although total implant devic use subcutan microphon develop compromis problem soft tissu sound attenu feedback intrus bodi nois vivo pilot studi evalu middl ear microphon mem aim overcom issu compar hear perform extern ci microphon | D003054;D013067;D019929 | T061;T074;T041 |
36,240,741 | snapshot cancer immunoedit tumor microenviron immun cell tumor cell interact process call cancer immunoedit give rise chang gene express metabol mutat burden cellular tumor snapshot compar endogen versus therapi induc cancer immunoedit outlin molecular cellular characterist interact result complet tumor regress versus tumor escap progress view snapshot open download pdf | D059016 | T070 |
36,240,740 | gpc unc receptor complex structur role cell migrat neural migrat critic step brain develop requir interact cell surfac guidanc receptor cancer cell often hijack mechan dissemin reveal crystal structur uncoordin receptor uncd complex morphogen receptor glypican gpc form octamer glycoprotein complex complex four uncd molecul pack antiparallel bundl flank four gpc molecul central glycan glycan interact form n link glycan eman gpc n human c mannosyl tryptophan uncd thrombospondin like domain md simul mass spectrometri structur base mutant valid crystallograph data anti gpc nanobodi enhanc weaken unc gpc bind togeth mutant protein show uncgpc guid migrat pyramid neuron mous cortex cancer cell embryon xenograft neuroblastoma model result demonstr conserv structur mechan cell guidanc fine balanc unc gpc interact regul cell migrat | D002465 | T043 |
36,240,739 | jak stat pathway much learn much discoveri janus kinas jak signal transduc activ transcript stat pathway aros investig cell respond interferon ifn reveal paradigm cell signal conserv slime mold mammal discoveri reveal mechan under rapid gene express mediat wide varieti extracellular polypeptid includ cytokin interleukin relat factor knowledg provid numer insight human diseas immun defici cancer rapid translat new drug autoimmun allerg infecti diseas includ covid despit advanc major challeng opportun remain | D000086382;D053612 | T116;T047;T126;T067 |
36,240,738 | dubl uncov x link vulner alzheim diseas although women higher risk alzheim diseas tauopathi under mechan unclear issu cell yan et al show aberr high activ x link usp deubiquitinas women impair clearanc tau princip compon neurofibrillari tangl alzheim diseas | D000544;D024801 | T047;T048 |
36,240,737 | vascular remodel sheep implant endovascular neural interfac object aim work assess vascular remodel placement endovascular neural interfac eni superior sagitt sinus sss sheep also assess efficaci neural record use eni approach studi use histolog analysi assess composit foreign bodi respons micro ct imag analyz assess profil foreign bodi respons creat model blood vessel comput fluid dynam model perform reconstruct blood vessel evalu blood flow within vessel record brain activ sheep use evalu efficaci neural record main result histolog analysi show accumul extracellular matrix materi around implant eni extracellular matrix contain numer macrophag foreign bodi giant cell new vascular channel line endothelium imag analysi ct slice demonstr uneven narrow sss lumen proport stent materi within blood vessel howev foreign bodi respons occlud blood flow eni abl record epileptiform spike activ distinct spike morpholog signific first studi show high resolut tissu profil histolog respons implant eni blood flow dynam model base blood vessel implant eni result studi use guid surgic plan futur eni design stent overs paramet blood vessel diamet consid minim detriment vascular remodel | D005547;D057510 | T061;T072;T020;T037 |
36,240,736 | use novel clinic decis make tool vestibular schwannoma treatment determin use person tool effect decis make process vestibular schwannoma vs | D009464 | T191 |
36,240,735 | segment vestibular schwannoma postop gadolinium enhanc weight noncontrast weight magnet reson imag use deep learn surveil postop vestibular schwannoma current reli manual segment measur tumor content expert labor intens time consum aim develop valid deep learn model automat segment postop vestibular schwannoma gadolinium enhanc weight magnet reson imag gdtwi noncontrast high resolut weight magnet reson imag hrtwi | D009464;D000077321 | T191;T066 |
36,240,734 | povidon iodin fail erad chronic suppur otiti media demonstr ototox risk mice commerci avail povidon iodin solut elimin biofilm persist cell rapid vivo achiev concentr without induc ototox | D010035;D000891;D000081015 | T121;T047;T046 |
36,240,730 | fluorescein assist microsurg resect vestibular schwannoma prospect feasibl studi evalu optim dose time administr sodium fluorescein sf select fluoresc sporad vestibular schwannoma vs microsurgeri yellow nm microscop filter ye character potenti benefit fluoresc determin intraop surgeon assess | D009464 | T191 |
36,240,729 | address transcrani electr stimul variabl prospect individu dose electr field strength particip across two sampl sped approach object transcrani electr stimul tes promis method modul brain activ excit variabl result date minim electr e field strength variabl introduc sampl prospect e field dose sped approach use e field strength induc tes first popul individu stimul intens second popul approach perform e field model three common tes montag healthi younger adult first permut analys identifi sampl size requir obtain stabl group averag e field primari motor cortex stabil defin number particip group averag e field strength standard deviat leav popul percentil rang second stabl group averag use individu tes intens second independ popul n impact individu versus fix intens tes e field strength variabl analyz main result first popul stabl group averag e field strength vm achiev particip depend tes montag individu stimul intens second popul result uniform e field strength p signific diminish peak cortic e field strength variabl p across montag signific sped feasibl way prospect induc uniform e field strength region interest futur studi might appli sped investig whether decreas e field strength variabl also result decreas physiolog behavior variabl respons tes | D065908 | T061 |
36,240,724 | model micropollut remov nanofiltr revers osmosi membran consider challeng organ micropollut omp drink water constitut potenti risk human health therefor effect remov pollut requir nanofiltr nf revers osmosi ro promis membran base technolog remov omp nf ro reject omp depend properti characterist membran solut solut review discuss properti includ model studi predict reject omp initi omp classif propos captur relev properti omp follow methodolog describ studi new omp easili includ classif classif aim increas comprehens mechanist understand omp remov base physicochem principl use classifi omp expect omp group similar reject classif present overview reject mechan involv remov specif omp group instanc discuss remov omp classifi perfluoroalkyl substanc eg perfluorooctano acid pfoa substanc high relev due human toxic extrem low concentr well persist omnipres environ final discuss reject omp predict describ membran solut interfac calcul transport solut insid membran illustr import impact differ reject mechan interfaci phenomena omp remov propos extend nernst plank equat calcul transport solut across membran due convect diffus electromigr final show theori discuss review lead improv predict omp reject membran | D018508;D060766;D005466;D004785;D014874 | T052;T167;T131;T057;T109 |
36,240,714 | adapt respons mechan granular floccul sulfat reduc sludg toward acid multi metal laden wastewat dissimilatori sulfat reduct base process long viabl option treat acid metal laden wastewat amw process optim enhanc sulfidogen activ microbi consortia resili harsh environ studi investig granular floccul sulfat reduc bacteria srb sludg respond amw well mechan adapt wastewat particular focus stabil sulfidogen activ metal remov bacteria resist long term floccul srb lost treatment capac day treat amw presenc cd cu zn ni mgl ph contrast granular srb maintain metal remov rate throughout day trial despit srb abund remain approxim organ partial oxid genera desulfobulbus desulfobact began domin due kinet advantag extracellular glycosyl composit reveal critic stabil granular structur microbi activ extracellular protein disintegr irrevers usag molecular dynam simul mobil metal ion srb granular system suppress presenc divers glycosyl composit compar floccul system diffus coeffici differ identifi glycosyl especi xylos rhamnos exhibit strong interact cu kj mol maximum bind strength cd glycosyl greater kj mol suggest low cd complex effici find studi shed light defens mechan srb granul multi metal stress provid clue effici amw treatment | D012722;D003901 | T007;T069 |
36,240,713 | compar investig pfas adsorpt onto activ carbon anion exchang resin long term oper pilot treatment plant widespread contamin groundwat per polyfluoroalkyl substanc pfas requir drink water produc quick adopt practic efficaci treatment limit human exposur deleteri health outcom pilot scale studi compar investig pfas adsorpt behavior granular activ carbon gac two strong base gel anion exchang resin aer column oper parallel day period treat contamin groundwat domin short chain perfluorocarboxyl acid pfca high resolv breakthrough profil homolog seri cf pfca perfluorosulfon acid pfsa includ ultrashort chain compound branch isom measur elucid adsorpt trend sampl port intermedi bed depth could predict breakthrough compound acceler basi lower empti bed contact time led conserv estim initi breakthrough homolog pfas seri display linear gac log linear aer relationship chain length breakthrough independ initi concentr aer general outperform gac normal bed volum basi advantag widen increas pfas chain length design treatment would short full scale servic time day gac day aer initi breakthrough short chain cf pfca howev aer display far longer breakthrough time pfsa compar gac treatment time breakthrough observ pfsa cf aer gac finit molar adsorpt capac total pfas lead stoichiometr replac short chain pfca pfsa longer chain pfca time aer quick reach finit adsorpt capac pfca show substanti greater select pfsa whose capac reach within durat pilot breakthrough characterist keto unsatur pfsa identifi groundwat suspect screen also evalu absenc refer standard modifi pfas structur branch keto unsatur broke faster linear unmodifi perfluorin structur equal degre fluorin effect pronounc gac compar aer result highlight design robust pfas treatment system consid facet beyond current pfas target includ oper complex impact unregul unmonitor co contamin | D005466;D018508;D014874 | T109;T131;T057;T052 |
36,240,712 | intrins mechan under high effici remov bacteri endotoxin relat risk tailwat dielectr barrier discharg plasma endotoxin wide present aquat environ induc advers health effect studi dielectr barrier discharg dbd plasma use remov bacteri endotoxin tailwat wastewat treatment plant remov effici total endotoxin activ low electr energi consumpt j ml dbd plasma treatment better previous report method earli stage dbd plasma oxid express gene relat cell morpholog bacteri antioxid enzym synthesi distinct regul suggest cell integr destroy lead endotoxin releas solut addit endotoxin synthesi cell suppress endotoxin solut effect remov oh generat dbd plasma second order reaction rate mol l respect core toxic compon endotoxin lipid attack strong oxid speci generat smaller molecular fragment low toxic consequ inflammatori factor il il tnf endotoxin decreas fold dbd plasma treatment impli health risk pose endotoxin great reduc studi reveal intrins mechan high effici remov bacteri endotoxin dbd plasma oxid | D018508 | T057;T052 |
36,240,711 | quantifi effect groundwat level recoveri groundwat nitrat dynam quasi integr model vados zone groundwat coupl system groundwat level gwl recoveri semiarid region attribut mitig countermeasur groundwat deplet potenti caus nitrat accumul vados zone introduc aquif howev extent gwl recoveri affect interact vados zone satur aquif migrat pathway soil nitrogen groundwat nitrat dynam explicit determin studi establish quasi feedback model vados zone groundwat coupl system typic gwl recoveri area quantit evalu effect gwl recoveri nitrat n leach flux via vados zone groundwat nitrat n dynam within framework integr model watercontamin leach flux depth groundwat exchang flow time step obtain result reveal tempor chang nitrat n leach flux depend behavior precipit farmland irrig litholog vados zone spatial pattern determin gwl undul vertic profil nitrat n content furthermor gwl recoveri caus magnitud nitrat n leach flux aquif increas along gwl recoveri phreatic aquif volum increas nitrat n mass herein increas larg driven nitrat n leach flux consequ averag groundwat nitrat n concentr gwl recoveri region increas approxim mgl apart artifici recharg rout find suggest intensifi leach soil contamin given circumst gwl recoveri negat effect groundwat qualiti appropri groundwat manag scheme therefor urgent requir achiev optim balanc gwl recoveri groundwat environ | D014874;D060587 | T082;T131;T081;T070 |
36,240,710 | anthropocen microplast stratigraphi xiamen bay china histori plastic product wast manag microplast mps consid one signific stratigraph marker onset anthropocen epoch howev interconnect histor plastic product wast manag well social econom time mp accumul well understood stratigraph data mps sediment core xiamen bay china use reconstruct histori plastic pollut general addit model indic complex tempor evolut mp accumul oldest mps deposit itemskgdw coincid infanc plastic industri onset anthropocen cultur revolut curtail initi increas subsequ rapid growth mps late peak itemskgdw follow drastic declin late low valu itemskgdw coincid prolifer mp sourc coupl evolut plastic product consumpt regul increas mps past decad impli previous mitig measur compromis escal influx mps increas plastic product legaci mps remain circul insuffici wast manag grow popul present methodolog result repres conceptu advanc understand chang polici econom time correl chang mp record anthropocen strata may help make decis plastic pollut mitig strategi worldwid | D014874;D018505 | T068;T131 |
36,240,709 | benzoquinon assist heterogen activ pms fe via format activ complex mediat electron transfer toward enhanc bisphenol degrad benzoquinon bq great signific enhanc contamin degrad homogen oxid system peroxymonosulf pms howev role bq heterogen activ pms contamin oxid still clear herein work report addit bq fe pms system could effect enhanc degrad miner bisphenol bpa mechanist studi uncov bq pms would form activ complex bq pms surfac fe excit bq pms oxid bpa specif electron bpa extract bq pms transfer surfac fe surfac electron induc chang valenc state fe element trigger degrad bpa inhibit decomposit bq best knowledg first time unveil posit role bq heterogen activ pms may shed new light establish high effici pms base oxid technolog remedi organ pollut | D004583;D010545 | T196;T081;T197 |
36,240,708 | silicon carbid catalyt ceram membran nano wire structur enhanc anti foul perform membran foul critic challeng current ceram membran suffer low flux insuffici remov develop self clean catalyt ceram membran promis address challeng herein design heterogen silicon carbid ceram membran featur novel structur g c n decor sic nano wire catalyt function layer enabl enhanc anti foul self clean perform chemic harsh alkalin especi acid condit nano wire membran exhibit catalysi enhanc remov perform organ contamin unlik convent particl pack membran structur nano wire network membran structur high poros except water permeanc lm h bar remov organ substanc simul sunlight outperform state art organ membran ceram membran superoxid radic experiment confirm major reactiv speci respons self clean function also propos catalyt mechan model radic format pathway enabl form g c n sic heterojunct structur reduc electron hole recombin work would provid new insight ration design next generat ceram membran self clean function also applic effici treatment refractori wastewat contain degrad organ substanc use membran | D057219;D018508 | T057;T052;T070 |
36,240,707 | accuraci improv determin seven minor tobacco alkaloid mainstream cigarett smoke use analyt protect gas chromatographi mass spectrometri tobacco alkaloid import precursor carcinogen tobacco specif nitrosamin therefor accur quantif tobacco alkaloid high import studi investig compens effect novel analyt protect ap matrix effect mes determin seven minor tobacco alkaloid nornicotin myosmin anabasin anatabin nicotyrin bipyridin cotinin mainstream cigarett smoke high accuraci robust compar height shape chromatograph peak addit ap standard solut prepar dichloromethan cigarett smoke solut compens effect ap combin mes seven minor tobacco alkaloid evalu best combin pyridylethylamin mgml decanediol mgml identifi ap combin could effect improv shape increas height chromatograph peak standard solut prepar dichloromethan cigarett smoke solut addit ap combin slope ratio calibr curv two type standard solut seven target chemic addit indic ap combin reduc matrix differ pure solvent cigarett smoke solut ad ap combin standard curv solut prepar dichloromethan show good linear r spike recoveri inter intraday precis respect three commerci cigarett sampl one mix standard solut also test four differ instrument work condit verifi long term accuraci rugged approach routin real world analysi method result show rsd valu higher without ap combin ap combin high accuraci precis robust method good practic prospect | D000073865;D062789;D000470 | T073;T131;T121;T055;T109;T123 |
36,240,701 | fish consumpt omega fatti acid intak risk pain senior enrica cohort omega fatti acid anti inflammatori analges anti nocicept action howev relat habitu omega fatti acid intak fish consumpt main food sourc pain remain larg unknown examin associ fish consumpt marin omega fatti acid intak pain incid worsen year among older adult | D015118;D015525 | T121;T109;T123 |
36,240,699 | effect cenobam cognit perform epilepsi patient cenobam cnb new antiseizur medic asm treatment focal epilepsi adult efficaci cnb confirm control clinic trial effect cognit unclear cognit advers effect asm affect qualiti life retent rate therefor investig whether adjunct treatment cnb associ chang cognit perform | D004827;D004828 | T047;T033 |
36,240,687 | tlr agonist nanoscal coordin polym synerg immun checkpoint blockad immunotherapi cancer immunotherapi includ immun checkpoint blockad icb becom integr treatment immunogen tumor reinvigor host immun function attack tumor cell howev clinic applic icb limit relat low respons rate well inher acquir resist mani type cancer potenti solut select deliv immun modul tumor activ tumor microenviron tme enhanc therapeut effect icb report design polyinosin polycytidyl acid pic nanoscal coordin polym ncp pic ncp abil activ tumor specif immun respons synerg icb potent antitumor effect prolong blood circul facil cell uptak trigger releas pic acid tmes pic ncp show robust tumor growth inhibit via activ endosom toll like receptor signal pathway synergist combin pic ncp icb control tumor growth syngen mous model colorect cancer spontan mous model prostat cancer studi highlight potenti ncp deliveri nucleic acid therapeut immun activ cancer therapi | D000082082;D009369 | T121;T191;T043;T129 |
36,240,686 | clinic outcom opioid administr acut chronic heart failur meta analysi opioid use heart failur hf manag controversi whether rapid symptomat relief outweigh risk opioid use hf remain unknown studi aim explor clinic outcom opioid administr patient acut chronic hf | D000701;D006333 | T047;T046;T131;T121;T109 |
36,240,685 | metabol unhealthi phenotyp normal weight popul risk mortal major advers cardiac event meta analysi prospect cohort studi still debat whether metabol status normal weight popul increas risk mortal caus mortal acm cardiovascular mortal cvm major advers cardiac event mace compar obes popul therefor meta analysi aim evalu associ metabol unhealthi normal weight muh nw phenotyp caus mortal cardiovascular mortal mace comparison metabol healthi obes mh along associ metabol unhealthi obes muh phenotyp regard outcom compar muh nw | D002318;D000067329 | T047;T184 |
36,240,684 | efficaci vitamin b supplement treat vitamin b defici peripher neuropathi metformin treat type diabet mellitus patient systemat review metformin treat type diabet mellitus tdm patient higher risk vitamin b defici sever neuropathi symptom still guidelin suggest vitamin b supplement popul studi aim analyz efficaci vitamin b supplement popul | D008687;D003924;D014806;D010523 | T121;T047;T109 |
36,240,669 | advanc neurovascular protect potenti n butylphthalid deriv diabet relat diseas n butylphthalid nbp compon isol seed chines celeri first approv treatment ischem stroke gradual depth understand pharmacolog action found may potenti effect treat diabet complic review aim illustr research properti nbp therapeut efficaci diabet relat diseas review discuss result experi vitro vivo make progress understand benefici effect nbp deriv diabet complic includ diabet vascular diseas diabet peripher neuropathi diabet brain relat diseas diabet cataract also demonstr nbp numer molecular target interact multipl cellular signal pathway oxid stress inflammatori respons apoptosi autophagi nbp prove potenti therapeut approach treat diabet complic | D001572;D048909;D003920 | T047;T109 |
36,240,668 | diabet dementia clinic perspect innov knowledg gap world face pandem level preval type diabet parallel massiv burden metabol diseas grow preval dementia popul age two health issu intertwin lancet commiss dementia prevent intervent care conven tackl grow global concern dementia identifi risk factor conclud along studi diabet well obes metabol syndrom broad frequent comorbid rais risk develop dementia type diabet modifi risk factor howev uncertain whether anti diabet drug mitig risk develop dementia reason manifold constitut critic knowledg gap field review outlin studi type diabet risk dementia illustr key concept moreov identifi knowledg gap review strategi help fill gap conclud seri recommend mitig risk advanc understand type diabet dementia | D003704;D003924;D024821;D000544 | T047;T048 |
36,240,666 | oncogen virus cancer biolog innat immun malign aris result viral infect account rough cancer case worldwid innat immun system bodi first line defens oncogen viral infect also involv respons viral driven tumor review discuss research advanc made last five year elucid innat immun system recogn respond oncogen virus virus evolv escap immun pressur way innat immun inform develop novel therapeut oncogen viral infect associ cancer | D014777;D009369 | T191;T047 |
36,240,661 | studi silver ion bind lactoglobulin drug resist pathogen phenomenon result infect death increas difficult treat requir research search new potenti antimicrobi agent present studi focus investig impact silver ion ag ion lactoglobulin lg structur mechan format silver lactoglobulin nanocomposit could find potenti applic medicin determin physicochem characterist silver ion bind kinet isotherm model use presenc function group involv bind process investig spectroscop method ftir atr raman spectroscopi bind abil nanocomplex format determin instrument analys sem tem edx base obtain result bind ag ion lg heterogen natur consist three main step rapid sorption ag ion lg surfac intramolecular diffus ag ion chemic equilibrium microscop studi show chang surfac morpholog lg appear silver nanoparticl spectroscop studi indic acid glu asp lys tyr met amino group play key role format aglg nanocomplex final molecular dynam md densiti function theori dft calcul studi compar complementari method proven contribut respect amino acid bind process | D012834;D053768 | T196;T073 |
36,240,656 | impact age murin cartilag biomechan chondrocyt situ calcium signal age promin risk factor osteoarthr onset etiolog age associ cartilag degener fulli understood recent studi guilak colleagu highlight crucial role cell matrix interact cartilag homeostasi diseas studi thus quantifi age associ chang cartilag biomechan chondrocyt intracellular calcium signal ca activ wild type mice month age age mice articular cartilag exhibit reduc stain sulfat glycosaminoglycan sgag indic decreas aggrecan content cartilag surfac collagen fibril undergo signific thicken retain transvers isotrop architectur exhibit sign fibril crimp month group composit structur chang contribut signific decreas cartilag modulus month age mpa mean ci n relat month mpa mpa respect n despit decreas sgag content tissu modulus chondrocyt exhibit signific demot ca activ situ physiolog isoton osmot instig hypo hyperton condit month age exist sub popul chondrocyt hyper activ ca respons hypoton stimuli possibl indic phenotyp shift chondrocyt age togeth result yield new insight age associ biomechan mechanobiolog chang murin cartilag provid benchmark elucid molecular mechan age relat chang cell matrix interact | D019902;D002358 | T025;T024 |
36,240,655 | growth buckl ruptur aneurysm cylindr tube analog aneurysm local bulg arteri ruptur fatal consequ complex mechanobiolog factor preclud vivo test assess ruptur risk aneurysm size base criteria often use clinic practic guid surgic intervent often found tortuous buckl aneurysm exceed size recommend surgic intervent yet ruptur studi address buckl aneurysm exhibit intrigu behavior combin vitro inflat experi hyperelast cylindr tube finit element calcul use biolog relev materi model arteri wall show buckl aneurysm grow size without ruptur favor arteri pre tension stretch revers phenomenon exhibit arteri govern whether buckl bulg occur first exponenti stiffen favor axial propag aneurysm instead radial growth size choic failur criteria base ogden strain energi function gent first stretch invari cauchi stress discuss failur map incorpor post bifurc bulg buckl respons construct delin regim growth buckl ruptur aneurysm | D000783;D002532 | T047;T046;T190 |
36,240,654 | imipramin prevent porphyromona gingivali lipopolysaccharid induc microgli neurotox porphyromona gingivali p gingivali gram negat anaerob involv pathogenesi chronic periodont includ local inflamm oral caviti howev periodont diseas recent identifi signific factor pathogenesi neural diseas includ alzheim diseas virul factor p gingivali lipopolysaccharid lps pg involv pro inflammatori respons peripher tissu also brain studi examin whether p gingivali induc brain inflamm could amelior pharmacotherapi use vivo vitro studi anim experi peripher administr lps pg induc inflamm hippocampus via microgli activ inhibit pre treatment antidepress imipramin similar lps pg induc inflamm mg cell mous microgli cell line inhibit pre treatment imipramin caus imipramin induc inhibit nf b signal cultur media obtain lps pg treat mg cell induc neuron cell death neuro cell mous neuroblastoma cell line prevent pre treatment mg cell imipramin result indic imipramin inhibit lps pg induc inflammatori respons microglia amelior periodont diseas relat neural damag | D016966;D010510 | T007;T047 |
36,240,653 | toll like receptor promot bladder cancer progress upon saa bind requir tirap mediat tpl activ bladder cancer often wide dissemin dead cancer block malign outgrowth bladder cancer must elucid molecular level characterist bladder cancer cell also surround milieu part effort long studi extracellular saa elev inflamm associ certain cancer extracellular enrich saa hasten shift metastat transit multipl type cancer cell intrigu high level saa detect urin bladder cancer patient level increas stage malign nonetheless saa investig main potenti biomark bladder cancer investig role bladder cancer growth metastasi herein report extracellular saa induc upregul growth migrat invas bladder cancer cell bind cell surfac toll like receptor tlr molecular analysi reveal tlr downstream signal acceler cancer cell event tumor progress locus tpl key factor facilit aggress cancer cell upon bind saa tlr tpl activ enhanc action tlr adaptor molecul tir domain contain adaptor protein tirap turn led activ mitogen activ protein kinas mapk cascad tpl final show sustain inhibit tlr cancer cell effect dampen cancer surviv vivo collect result indic saa tlr tpl axi influenc growth surviv invas motil bladder cancer cell | D051197;D001749 | T191;T116;T192 |
36,240,652 | aerob exercis improv intestin mucos barrier dysfunct tlrmydnf b signal pathway diabet rat studi examin effect aerob exercis intestin mucos barrier dysfunct diabet rat establish diabet rat model consist three group normal control nc diabet control dc diabet eight week aerob exercis de measur serum fast blood glucos fbg insulin in diamin oxidas dao lactat lac lipopolysaccharid lps tumour necrosi factor tnf interleukin il insulin resist index homa ir intestin section tissu stain h e examin use transmiss electron microscopi express occludin claudin toll like receptor tlr myeloid differenti primari respons protein myd nuclear factor b nf b small intestin mucosa determin western blot comparison nc fbg homa ir dao lac tnf il lps increas p dc wherea in villus height crypt depth mucos thick decreas p comparison dc fbg dao lac tnf lps decreas p de wherea in villus height crypt depth mucos thick increas p comparison nc occludin claudin decreas p dc wherea tlr myd nf b increas p comparison dc occludin claudin increas p de wherea tlr myd nf b decreas p conclus eight week aerob exercis improv intestin mucos barrier dysfunct diabet rat inhibit lps releas tlrmydnf b signal pathway pro inflammatori cytokin express | D016328;D003921 | T050;T116;T129 |
36,240,651 | plasma unconjug bile acid novel biomark schizophrenia studi measur conjug unconjug free bile acid bas plasma patient schizophrenia healthi subject examin possibl ba biomark schizophrenia although level ba conjug show signific differ signific differ three unconjug bile acid observ plasma patient schizophrenia healthi subject addit three time differ patient healthi subject observ mean valu total concentr primari bas result indic cholic acid chenodeoxychol acid level plasma may novel diagnost marker sub popul patient schizophrenia thus futur studi elucid relationship increas ba level patholog schizophrenia verifi potenti unconjug ba plasma biomark schizophrenia | D001647;D012559 | T109;T123;T048 |
36,240,650 | add protect renal cell cold injuri improv energi metabol static cold storag scs current wide use method organ preserv number limit associ includ tissu damag restrict opportun organ repair thus develop improv hypotherm storag solut urgent need herein use renal epitheli cell model llc pk test benefit add novel clinic grade antioxid product reduc damag associ ischemia reperfus ir cell store h c univers wisconsin uw solut without presenc add follow reperfus h c presenc add signific decreas cell damag cell death level reactiv oxygen speci ros p concomit add supplement also favor increas oxygen consumpt rate ocr improv bioenerget llc pk cell p final preliminari vivo studi suggest benefit add renal function post transplant conclus result demonstr addit add preserv solut effici protect renal cell scs also improv function cold store organ transplant | D019188;D015427;D016030;D000067390 | T061;T037;T122 |
36,240,648 | quantifi maerl rhodolith habitat complex along environment gradient region scale northeast atlant maerl bed ecolog import marin biogen habitat found speci free live corallin alga aggreg form high complex rhodolith high biodivers found habitat main justifi structur complex provid howev attempt quantifi complex made maerl speci distribut densiti rhodolith growth form shape vari environment condit hydrodynam depth shown drive morpholog use speci specif metric spheric branch densiti well diamet fractal dimens rhodolith level maerl densiti habitat level quantifi habitat complex within ten maerl bed region scale along km coastlin brittani western franc use long term monitor data environment model investig maerl habitat complex vari among bed environment condit drive differ effect current exposur wind generat wave temperatur sediment granulometri evalu confirm variat complex maerl bed habitat rhodolith level local region scale might ecolog conserv implic associ biodivers analys environment condit drive around third varianc habitat complex sediment granulometri main driver maerl habitat complex brittani isol effect depth hydrodynam account less variabl result import implic paleoecolog suggest maerl faci interpret care studi provid first attempt explicit quantifi maerl habitat complex contribut understand fundament ecolog question | D000461 | T002 |
36,240,646 | novel flexibl porous nanofibr hydrogel interfaci solar evapor high effici seawat wastewat purif solar desalin recogn one eco friend sustain way allevi global freshwat crisi still requir research especi develop high perform evapor herein prepar effici carbon nanotub cnts polyvinyl alcohol pva nanofibr hydrogel evapor electrospin subsequ chemic cross link treatment due cnts good light absorpt capac evapor exhibit excel light absorpt capac throughout full spectrum rang nm meanwhil interconnect pore electrospin well intermedi water hydrogel ensur prepar evapor favor evapor rate kg h phototherm convers effici one solar light intens long term seawat desalin cnts pva nanofibr hydrogel evapor also present superior salt resist durabl good self clean properti besid various non volatil pollut complet remov prepar evapor wastewat purif result work consid provid new direct develop high perform evapor provid freshwat seawat desalin wastewat purif | D003929;D003925;D037742;D057139;D018508;D004785 | T047;T073;T052;T131;T057;T104 |
36,240,644 | generat two heterozyg gaa mutat carri human induc pluripot stem cell line xachi xachi parent infant pomp diseas pomp diseas result gaa mutat lead lysosom glycogen accumul cardiac skelet muscl patholog previous generat infantil onset pomp diseas patient deriv human induc pluripot stem cell ipsc line carri compound gaa mutat rx ex use parent peripher blood mononuclear cell pbmcs generat two ipsc line carri mutat rx ex respect line show typic cell morpholog high express pluripot self renew marker normal karyotyp trilineag differenti potenti two line valuabl sourc studi patholog mechan gaa mutat caus pomp diseas | D006009;D057026 | T047;T025 |
36,240,643 | exosom deriv human umbil cord mesenchym stem cell hucmsc exo regul autophagi ampk ulk signal pathway amelior diabet cardiomyopathi one main caus sever diabet heart failur mortal diabet cardiomyopathi dcm cardiovascular condit attribut diabet high incid complic unexplain pathophysiolog poor treatment result current find demonstr onset diabet cardiomyopathi involv autophagi inflamm mitochondri damag myocardi autophagi behav differ differ state one target detect treatment cardiovascular ill like diabet cardiomyopathi may control autophagi role human umbil cord mesenchym stem cell deriv exosom hucmsc exo non cellular system repair cardiomyocyt evolut diabet cardiomyopathi cardioprotect effect gradual recogn studi object assess therapeut benefit hucmsc exo diabet cardiomyopathi look potenti mechan action high speed centrifug use extract hucmsc exo shape exosom examin use transmiss electron microscopi immunoblot use determin express cd cd tsg molecul surfac exosom high fat high sugar diet mix streptozotocin use build rat model type diabet cardiomyopathi cardiac function ventricular wall thick cardiac histolog chang examin cardiac ultrasound serum bnp histolog cardiac myocyt hucmsc exo reduc level autophagi relat protein express addit immunoblot support suspicion mechan strong tie activ ampk ulk signal pathway propos would good strategi follow treat diabet cardiomyopathi find offer fresh concept build model diabet cardiomyopathi creativ theoret framework use hucmsc exo treat diabet cardiomyopathi clinic set | D001343;D003920;D058065;D055354;D059630 | T043;T026;T025;T047 |
36,240,632 | post respons intertid bivalv recurr heatwav heatwav becom hotter longer frequent threaten surviv intertid bivalv devast ecosystem yet substanti overlook heatwav induc post respons import assess cascad consequ investig respons intertid bivalv ruditap philippinarum recurr heatwav physiolog gene express analys demonstr mantl tissu r philippinarum sensit respond heatwav reveal post respons recoveri scenario gene relat essenti physiolog fit regul st recoveri period follow repeat exposur gene regul line signific increas activ energi metabol enzym antioxid nonspecif enzym regul gene involv biominer nevertheless observ recoveri scenario impli trade essenti physiolog fit relat function find pave way understand physiolog plastic marin bivalv respons intensifi heatwav | D017753;D049872 | T082;T204;T070 |
36,240,631 | stabl symbiodiniacea composit three coral speci natur bleach event subtrop hong kong adapt chang endosymbiot symbiodiniacea communiti report bleach event tropic coral speci littl known shift subtrop speci examin symbiodiniacea communiti three coral speci montipora peltiformi pavona decussata platygyra carnosa base sampl collect bleach event subtrop hong kong water collect sampl meta sequenc reveal p decussata p carnosa predomin associ cladocopium c cc wherea peltiformi main associ two cladocopium c type c speci predomin endosymbiont exhibit high fidel relat low abund type show minor chang bleach recov coral studi provid first detail coral algal associ hong kong water suggest select certain genotyp potenti adapt mechan margin environment condit | D037421;D004141 | T204 |
36,240,630 | function catalyt nanoparticl nanozym sens nanoparticl exhibit divers shape high poros chemic stabil reveal upon appropri chemic engin enzym like catalyt activ nanozym provid plethora nanomateri divers applic present review articl address sens applic catalyt function nanozym consist metal nanoparticl metal oxid metal sulfid cyanometal nanoparticl carbon base nanomateri metal organ framework nanoparticl nanozym emul catalyt function oxidas peroxidas employ amplifi agent sens divers analyt glucos dopamin nadh thiol phosphat moreov immobil nanozym electrod provid versatil mean develop electrochem sens platform differ principl electrochem sens platform synthet methodolog deposit nanozym electrod method establish electr communic bulk conduct support nanozym particl introduc electrochem sens platform appli nanozym modifi electrod detect analyt organophosph glucos discuss particular applic nanozym amplifi label biosensor devic detect protein dna microrna address final use nanozym function constitu design sens treat system discuss exemplifi assembl bioreactor system sens glucos nanozym promot generat reactiv oxygen speci cytotox agent toward cancer cell autonom nanozym base glucos control releas insulin nanocarri devic futur challeng develop nanozym base sensor sens treat system present | D000073396;D015374;D049329;D053768;D035683;D061385 | T073;T059;T121;T075;T109;T123;T114 |
36,240,629 | sensit specif nano vehicl base self amplifi dual input synthet gene circuit intracellular imag treatment synthet genet circuit sgcs sens multipl biomark respond intellig provid power tool intracellular biosens sgc usual load nanoscal liposom build function intracellular nano vehicl wide appli diagnos treat diseas howev system need identifi multipl target activ sensit inevit reduc though specif improv lead fals negat result diagnosi low kill dosag treatment compromis specif sensit bottleneck problem field innov invent self amplifi dual input sadi sgc liposom nano vehicl broke bottleneck problem provid multipl site regul sensit coars fine level allow research conveni balanc sensit specif accord applic instrument setup recogn ovarian cancer cell nano vehicl could enhanc sensit near fold specif remain high level fold also chang output fluoresc signal output effector apoptosi regul bax prolifer inhibit protein p demonstr applic rang furthermor verifi general system appli target differ cell believ provid conveni power tool biosensor target therapi | D015374 | T059;T075 |
36,240,628 | situ bio assembl specif au ncs aptam pyro conjug nanoprob tumor imag mitochondria target photodynam therapi mitochondrion emerg promis drug target photodynam therapi pdt due signific role support life activ reactiv oxygen speci ros sensit herein establish new strategi situ bio synthes au ncs combin mitochondria target aptam pyro conjug appc specif tumor imag pdt prepar appc serv templat situ bio synthesi au ncs therebi facilit generat au ncs appc assembl uniqu tumor microenviron compar high negat charg appc bio synthes nanoscal au ncs appc assembl conduc cell uptak consequ benefit deliveri appc dissoci au ncs appc intern appc select accumul mitochondria generat excess ros disrupt mitochondri membran upon irradi thus induc effici cell kill vitro assay demonstr fluoresc au ncs appc assembl could specif produc cancer cell indic specif tumor imag abil intracellular appc co local well mitochondria cck result reveal cell death pdt vivo studi show fluoresc au ncs appc assembl exclus generat tumor achiev long term retent tumor growth signific inhibit day pdt treatment evid suggest situ bio synthes au ncs appc assembl potent mitochondria target nanoprob boost pdt efficaci cancer | D010778;D015374;D009369;D053768 | T073;T059;T061;T191;T075 |
36,240,627 | biolog modul organ photoelectrochem transistor situ enzymat engin photoact gate sensit detect serum alkalin phosphatas innov optoelectron expect play import role clinic diagnosi studi basi sensit gate effect situ enzymat function semiconductor novel organ photoelectrochem transistor opect detect serum alkalin phosphatas alp level demonstr specif opect detect oper upon alp catalyz hydrolysi sodium thiophosph yield hydrogen sulfid h could situ generat cds tio electrod presenc cd cation correl alp level cds direct form interfac tio could sensit gate poli ethylenedioxythiophen poli styren sulfon pedot pss channel allow uniqu optoelectron detect serum alp level linear rang u l detect limit correspond u l sn studi offer optoelectron method detect serum alp level also perspect uniqu opect gate applic moreov general catalyt abil enzym produc function speci rich interact various gate substrat provid great space futurist opect detect enzym associ diseas | D015374;D006862 | T059;T131;T075;T130;T197 |
36,240,619 | factor influenc pig farmer percept attitud toward antimicrobi use resist antimicrobi resist amr increas concern livestock product usag link emerg resist bacteria human intricaci uk pig product system alongsid limit research farmer percept highlight need investig farmer percept attitud gain understand factor influenc antimicrobi use amu therefor studi aim qualit explor pig farmer view amu amr identifi specif factor influenc antibiot administr practic uk pig industri | D000067565;D000890 | T121;T097 |
36,240,614 | outcom prednison taper regimen cardiac sarcoidosi retrospect analysi demonstr benefit infliximab optim treatment strategi cardiac sarcoidosi standard examin effect three prednison taper treatment regimen cardiac sarcoidosi | D008727;D012507 | T121;T047;T109 |
36,240,605 | non saccharomyc yeast beer product insight safeti aspect consider applic non saccharomyc yeast beer natur tool innov creat differ aroma profil flavour non alcohol beer attract great interest research commerci brewer result higher divers non saccharomyc yeast beer product expect market come year howev safe use non saccharomyc yeast broad investig guidanc safeti assess yeast publish fundament safeti assess includ accur taxonom speci identif use date method along literatur studi regard yeast speci question strain specif safeti concern assess involv pathogen potenti antifung resist product biogen amin possibl allerg reaction howev yeast safeti assess infanc compar bacteri safeti assess research need set cut valu antifung resist identifi potenti virul gene valid screen tool assess yeast strain final individu breweri respons safeti relat process yeast appli throughout shelf life beer applic non saccharomyc yeast industri beer product promis term defin new prototyp develop healthier safer beer good food safeti measur ie strain product process place throughout food valu chain way ancient role yeast make beverag safer therebi improv food safeti emphas | D001515;D000935 | T121;T168;T195 |
36,240,604 | effect bacteri deriv antimicrobi solut shelf life microbiota sensori attribut raw chicken leg refriger storag condit present studi bacteri deriv antimicrobi agent includ mm reuterin combin either mm lactic acid rl microcin j rj evalu effect microbiota sensori attribut raw chicken leg peracet acid mm convent chemic common use poultri industri use posit control compar efficaci chicken leg spray antimicrobi solut aerob store c day rl treatment maintain total viabl count limit log cfug th day therefor compar nontreat group shelf life extend day rl treat group rj treatment extend shelf life day similar achiev use peracet acid base cultur independ amplicon sequenc rl rj treatment affect microbi communiti chicken leg induc delay increas pseudomona psychrobact carnobacterium decreas shigella signific decreas sensori score occur nontreat group slight chang occur combin treat group period overal sensori properti score chicken leg treat rl rj remain higher p treat peracet acid without antimicrobi agent antimicrobi combin delay deterior sensori attribut throughout storag period result suggest rl rj provid promis natur sourc antimicrobi approach control growth spoilag microorgan chicken leg | D004202;D064307 | T167;T131;T028;T001;T032 |
36,240,603 | deciph virul potenti listeria monocytogen norwegian meat salmon process industri combin whole genom sequenc vitro data whole genom sequenc wgs foodborn pathogen listeria monocytogen global rise food industri provid improv proactiv surveil sourc track allow depth genet character pathogen present studi virul gene profil includ virul gene l monocytogen isol norwegian meat salmon process industri character isol collect compris clonal complex ccs occur global addit determin vitro virul potenti major ccs human intestin epitheli caco cell use cocktail three six repres isol aim test whether virul potenti could predict virul gene profil estim applic potenti wgs risk assess food industri virul gene profil high conserv within individu ccs similar among phylogenet close relat ccs observ cc associ distribut accessori virul gene addit differ length polymorph furthermor detect differ prematur stop codon pmsc inla gene main present cc cc cc isol accord cc cc unabl invad caco cell wherea cc show moder virul potenti due presenc isol harbor full length inla highest invas observ cc cc potenti due presenc accessori virul gene demonstr cc harbor full length inla unabl invad caco cell due low inla gene express reconstruct inla cc cc isol show without presenc inla cell wall detect cc isol invas host cell fail studi show predict virul potenti base genet virul profil provid valuabl inform risk assess food industri also limit mere presenc full length inla gene suffici virul gene express presenc protein cell wall requir success invas l monocytogen host cell moreov hypovirul ccs like cc among abund human clinic isol norway despit harbor pmsc mutat inla gene conclus studi highlight combin genotyp phenotyp data great import improv inform valu appli wgs food industri | D008089;D008088 | T007;T047 |
36,240,592 | domest space crucibl paleolith cultur archaeolog perspect place peopl live sleep prepar food undertak activ known variabl home residenti site live site domest space play key role emerg evolut modern human cultur dynam influenc domest space began earli human evolutionari histori paleolithicston age draw exampl africa western eurasia articl explor aspect chang social cultur signific domest space throughout time use sever line evid repeat site visit behavior structur live space inform gain dissect palimpsest record develop pyrotechnolog live site becom hearth center domest space provid common hub activ time activ around hearth increas complex divers pars palimpsest record archaeologist also reveal chang natur varieti intens site activ time indic shift site function spatial express cultur norm archaeolog evid show entwin develop domest space human cultur activ gradual albeit nonlinear lower paleolith upper paleolithiclat middl stone age process domest space emerg common arena opportun social interact knowledg transmiss qualiti may contribut enhanc develop cumul cultur paleolith societi | D001106 | T090;T091 |
36,240,591 | transcriptom analysi reveal hepatotox zebrafish induc cyhalofopbutyl cyhalofopbutyl high effect aryloxyphenoxypropion herbicid wide use weed control paddi field increas residu cyhalofopbutyl pose threat surviv aquat organ investig effect cyhalofopbutyl zebrafish explor potenti hepatotox mechan result show cyhalofopbutyl induc hepatocyt degener vacuol necrosi larva embryon exposur day caus liver atrophi day meanwhil activ enzym relat liver function signific increas mgl cyhalofopbutyl higher alanin transaminas alt aspart transaminas ast content triglycerid tg involv lipid metabol signific decreas mgl cyhalofop buti express gene relat liver develop also signific regul furthermor transcriptom result show pathway involv metabol immun system endocrin system signific impact may relat hepatox sum present studi demonstr hepatox caus cyhalofop buti under mechan result may provid new insight risk cyhalofopbutyl aquat organ new horizon pathogenesi hepatotox | D014874;D006540;D056486 | T047;T131;T037 |
36,240,588 | sequenc divers uniparent transmit portion genom resid popul catalonia genom refer databas resid popul avail differ countri region sinc repres whole genet divers geograph region wide applic biomed studi forens identif uniparent transmit portion genom specif high suitabl kinship analys mix dna case geograph ancestri infer sampl individu current resid catalonia within gcat cohort generat high qualiti whole mitochondri dna mtdna genom sequenc male specif part chromosom msi observ higher genet divers classic popul genet dataset test robust whole sequenc unequivoc identif found higher resolut mitochondri control region chromosom short tandem repeat strs variant present low frequenc increas discrimin capac individu result confirm forens applic whole uniparent sequenc provid one largest high qualiti refer dataset ever publish | D018895;D005828 | T090;T123;T114 |
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