PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,240,077 | imag featur liver stereotact bodi radiat therapi histor radiat therapi consid treatment liver tumor owe risk radiat induc liver diseas howev develop high conform radiat treatment stereotact bodi radiat therapi sbrt increas use radiat therapi liver sbrt indic treatment primari metastat liver tumor outcom compar local therapi especi treatment hepatocellular carcinoma sbrt imag featur tumor surround background hepat parenchyma demonstr predict pattern immedi treatment follow goal sbrt deliv lethal radiat dose target liver tumor minim radiat dose normal liver parenchyma adjac organ evalu tumor respons sbrt center chang size enhanc howev chang often delay secondari under physiolog effect radiat knowledg under pathophysiolog mechan sbrt allow better understand typic imag featur detect tumor respons avoid misinterpret common pitfal atyp imag find imag featur radiat induc chang surround liver parenchyma character focal liver reaction potenti mistaken respons recurr tumor knowledg pattern chronolog phenomenon may allay uncertainti assess tumor respons pitfal relat fiduci marker placement combin therapi import recogn author review basic principl sbrt illustr post sbrt imag featur treat liver tumor adjac liver parenchyma focus avoid pitfal imag evalu respons onlin supplement materi avail articl rsna | D016634;D006528;D008113;D011832 | T191;T061;T047;T037 |
36,240,075 | imag immun checkpoint inhibitor immunotherapi non small cell lung cancer normal immun system identifi elimin precancer cancer cell howev tumor develop immun resist mechan one involv exploit pathway term immun checkpoint normal suppress cell function goal immun checkpoint inhibitor ici immunotherapi boost cell mediat immun mount effect attack cancer cell ici chang treatment landscap advanc non small cell lung cancer nsclc numer ici approv first line treatment nsclc us food drug administr ici caus atyp respons pattern pseudoprogress wherebi tumor burden initi increas decreas therefor respons criteria develop specif patient receiv immunotherapi ici activ immun system lead inflammatori side effect term immun relat advers event ira usual occur within week month start therapi ira rang asymptomat abnorm laboratori result life threaten condit enceph pneumon myocard hepat coliti import awar imag appear various ira avoid misinterpret metastat diseas progress diseas infect basic principl ici therapi indic ici therapi set nsclc respons assess atyp respons pattern ici therapi compar convent chemotherapi spectrum ira seen imag review invit commentari nishino avail onlin rsna | D002289;D008175;D064420 | T191;T046;T037 |
36,240,073 | toxic studi usnea lichen contain usnic acid administ feed fn nctr rat bcfnctr mice usnea lichen purifi usnic acid use histor tradit herbal medicin bactericid antimicrobi agent usnea lichen contain usnic acid extract lichen current market unit state herbal antimicrobi agent usnic acid exhibit membran proton uncoupl activ form mechanist basi bactericid action also provid rational use fat burn weight loss agent purifi usnic acid market unit state purpos either alon combin chemic agent use fat burn product contain usnic acid result serious liver damag studi investig potenti toxic ground usnea lichen contain usnic acid male femal fischer n nctr rat bcfnctr mice expos via feed month fn nctr rat administ ppm feed bcfnctr mice administ ppm feed abstract abridg | D019440;D008011;D020949 | T121;T004;T002 |
36,240,069 | mechan tnf independ ripk mediat cell death apoptosi necroptosi regul mani aspect organism biolog involv various human diseas tnf well known induc form cell death under mechan elabor describ howev cell also engag apoptosi necroptosi tnf independ mechan involv exampl activ pattern recognit receptor toll like receptor tlr zdna bind protein zbp context cell death signal depend presenc receptor interact serinethreonin protein kinas ripk wherea ripk requir tnf induc necroptosi mediat apoptosi necroptosi upon tlr zbp engag review intric mechan tnf independ cell death regul ripk | D053422;D051196 | T126;T116;T192 |
36,240,068 | claspin haploinsuffici lead defect fertil hyperplasia increas oncogen potenti claspin adaptor protein requir atr depend phosphoryl chk phase follow dna replic stress claspin express high variabl cancer low level frequent correl poor patient surviv learn biolog consequ reduc claspin express effect tumorigenesi investig mice heterozyg knockout clspn gene claspin haploinsuffici result reduc femal fertil matern inherit defect oocyt meiosi cell cycl progress furthermor age clspn mice develop spontan lymphoid hyperplasia increas suscept non alcohol fatti liver diseas import demonstr tumour suppressor role claspin reduc claspin level result increas liver damag tumourigenesi den model hepatocellular carcinoma data reveal clspn haploinsuffici widespread unanticip biolog effect establish import claspin regulatori node control tumorigenesi multipl diseas aetiolog | D004261;D057895 | T045;T049 |
36,240,067 | regul pikakt rhoracpak signal pathway chk inhibitor resist e myc lymphoma cell develop resist activ bypass pathway signal repres major problem clinic applic protein kinas inhibitor investig effect either c rel delet relata phosphosit knockin e myc mous model b cell lymphoma discov nf b subunit mutat result chk inhibitor resist aris either loss alter chk activ respect howev sinc e myc lymphoma depend chk activ cope high level dna replic stress consequ genom instabl clear mutant nf b subunit lymphoma abl surviv understand surviv mechan identifi potenti compensatori bypass signal pathway lymphoma appli multi omic strategi c rel e myc lymphoma observ high level phosphatidyl inositol kinas pik akt pathway activ moreov treatment pik inhibitor pictilisib gdc select inhibit growth reimplant c rel relata wild type wt e myc lymphoma also observ regul rhorac pathway gene express signatur e myc nf b subunit mutat model investig demonstr activ rhorac effector p activ kinas pak pak inhibitor pf success overcam resist relata wt lymphoma find demonstr regul multipl bypass pathway occur chk inhibitor resist e myc lymphoma consequ drug target pathway could potenti use either second line combinatori therapi aid success clinic applic chk inhibitor | D008223;D019869 | T191;T126;T116 |
36,240,066 | regul chk inhibitor resist c rel usp depend pathway previous discov delet c rel e myc mous model lymphoma result earlier onset diseas find contrast expect function nf b subunit b cell malign report e myccrel cell unexpect major defect chk pathway total phospho proteom analysi reveal e myccrel lymphoma high resembl wild type wt e myc lymphoma treat acut dose chk inhibitor chki cct analysi demonstr consequ e myccrel lymphoma lost express chk protein effect also result resist cct treatment vivo similar regul chk protein level also seen chki resist uo osteosarcoma huh hepatocellular carcinoma cell investig reveal deubiquitinas usp regul chk proteolyt degrad regul model system respons least part effect demonstr treat wt e myc lymphoma cell usp inhibitor ml high effect reduc tumour burden vivo target usp activ may thus altern therapeut strategi myc driven tumour | D008223;D016271 | T191;T123;T116 |
36,240,056 | modifi architect serolog assay enabl plasma level perform dri blood spot sampl dri blood spot dbss provid altern sampl input serolog test evalu dbss architect hepat b surfac antigen hbsag next hepat b e antigen hbeag anti hepat b core antigen anti hbc ii hiv antigenantibodi agab combo advisedx sar cov igg ii assay assay perform dbss assess without assay modif compar market assay plasma sampl dbs stabil also determin hbsag next hiv agab combo assay use dbss show sensit specif compar market assay modifi hbeag anti hbc ii sar cov igg ii dbs assay achiev perform compar market assay use dbss input high throughput serolog assay expect signific implic improv popul surveil increas access diagnost test | D000086382;D015658 | T047;T067 |
36,240,053 | two type subgroup valenc heteroatom p iii te iv synergist control octa ce iii encapsul heteropolyoxotungst electrochem recognit properti rapid develop synthet chemistri polyoxometal pom great driven generat structur variabl innov pom base materi herein synthes novel p iii te iv synergist control octa ce iii encapsul heteropolyoxotungst h n ch k na h ce ch coo hp iii w h b tew b tew h distinct anion skeleton ce ch coo hp iii w h b tew b tew built two tetra vacanc b tew four tetra vacanc b tew moieti link inorgan organ hybrid ce ch coo hp iii w h ce p w cluster core interest ce p w assembl four w group two hp iii anion eight ce ion besid composit carboxyl multiwal carbon nanotub cmcn result bi compon cmcn nanocomposit electrochem recognit platform name cmcngce built modifi cmcn glassi carbon electrod gce electrochem detect dopamin dpa physiolog ph ph find shown cmcngce exhibit good detect limit nm dpa work provid consider inspir promot innov ration structur design pom base materi expand applic electrochem biolog detect field | D055664;D037742 | T059;T104;T073 |
36,240,040 | offlin onlin associ camera awar proxi unsupervis person identif recent unsupervis person identif id receiv increas research attent due potenti label free applic promis way address unsupervis id cluster base generat pseudo label cluster use pseudo label train id model iter howev cluster base method take cluster pseudo ident class neglect intra cluster varianc main caus chang camera address issu propos split singl cluster multipl proxi accord camera view camera awar proxi explicit captur local structur within cluster intra id varianc inter id similar better tackl assist camera awar proxi design two proxi level contrast learn loss respect base offlin onlin associ result offlin associ direct associ proxi accord cluster split result onlin strategi dynam associ proxi term date featur reduc nois caus delay updat pseudo label combin two loss enabl us train desir id model extens experi three person id dataset one vehicl id dataset show propos approach demonstr competit perform state art method code avail https githubcomterminatorocap | D056667 | T066 |
36,240,030 | toxic studi usnic acid administ feed fn nctr rat bcfnctr mice usnic acid secondari metabolit lichen belong usnea genus usnea lichen purifi usnic acid use histor tradit herbal medicin bactericid antimicrobi agent usnic acid exhibit membran proton uncoupl activ form mechanist basi bactericid action also provid rational use fat burn weight loss agent purifi usnic acid market unit state purpos either alon combin chemic agent use fat burn product contain usnic acid result serious liver damag studi investig potenti toxic usnic acid male femal fn nctr rat bcfnctr mice expos via feed month fn nctr rat administ ppm feed bcfnctr mice administ ppm feed abstract abridg | D019440;D020949 | T121;T004;T002 |
36,240,027 | mass screen sar cov rapid antigen test reced omicron wave popul base survey epidemiolog evalu covid omicron ba epidem wave hong kong peak first quarter follow implement stringent public health measur daili number report case fell although outbreak steadili reced govern roll day voluntari univers rapid test campaign invit citizen self perform rapid antigen test rat daili identifi undetect preval infect | D000086402;D000086382 | T067;T047;T005 |
36,240,022 | relationship popul level sar cov cycl threshold valu trend covid infect longitudin studi distribut popul level real time revers transcript polymeras chain reaction rt pcr cycl threshold ct valu proxi viral load may use indic predict covid dynam | D000086402;D000086382 | T067;T047;T005 |
36,240,021 | altrici bird earli stage embryo express molecular machineri respond modul matern thyroid hormon cue abstractmatern hormon thyroid hormon ths transfer embryo egg key signal pathway mediat matern effect abl respond matern cue embryo must express key molecular machineri hormon pathway enzym receptor altrici bird begin th product hatch experiment evid suggest phenotyp influenc matern ths deposit egg howev understood altrici bird express gene th pathway first time measur express key th pathway gene altrici embryo use two common altrici ecolog model speci pie flycatch ficedula hypoleuca blue tit cyanist caeruleus deiodinas dio gene express could reliabl confirm either speci deiodinas enzym gene dio dio express speci given dio convert thyroxin biolog activ triiodothyronin dio most convert triiodothyronin inact form ths result suggest embryo may modul matern signal th receptor thra thrb monocarboxyl membran transport gene slca also express enabl th respons result suggest altrici embryo may abl respond potenti modul matern signal convey ths earli develop | D013974;D014284 | T121;T109;T116;T125 |
36,240,013 | divers tailor photoelectrochem properti carbon dot conspectusa new kind carbon base function materi carbon dot cds spark much interest recent year tunabl structur composit morpholog cds unlock opportun enabl divers photoelectrochem properti thus show great potenti various applic biolog catalysi sensor energi storag nevertheless relat understand cds insuffici present due inher complex microstructur involv intersect high polym bulk carbon quantum dot qd good understand under mechan behind properti cds still formid challeng requir integr robust knowledg organ chemistri materi scienc solid state physic within context discov appeal properti elucid fundament factor affect properti propos effect engin strategi realiz specif function cds high pursu researchersat begin account main featur cds introduc basic structur composit morpholog characterist also rich photoelectrochem properti elucid among band gap chiral photoinduc potenti electron sink effect particular emphas furthermor new analysi techniqu includ transient photoinduc current tpc transient photoinduc voltag tpv machin learn ml reveal uniqu properti cds describ sever appeal strategi aim ration tailor cds orient applic highlight regul strategi morpholog modul eg develop cds new geometr configur control particl size phase engin eg alter phase crystallin introduc foreign atom surfac function eg graft various type function group interfaci tune eg build cd base nanohybrid well defin interfac although fundament investig cds relat undevelop complex hinder wide applic time explor extens applic cds promot depth understand final chanc build cd center blueprint sustain societi explor challeng futur research field cds propos follow control synthesi cds uniform size ii search novel cds uniqu structur morpholog composit iii quantit understand properti cds iv perform enhanc extern forc magnet heat inject v construct dual carbon concept vi research differ photocatalyt applic whole account may provid meaning refer understand microstructur properti correl well regul cds therebi promot transit fundament research practic applic | D002244;D045663 | T121;T196;T073 |
36,240,008 | cultur digit health literaci appropri app web base system design pregnant women gestat diabet mellitus scope review preval women diagnos gestat diabet mellitus gdm increas dramat mobil technolog enhanc patient self manag offer mani advantag women diagnos gdm howev knowledg although mobil health mhealth telemedicin system gdm manag exist evid cultur digit health literaci appropri level limit | D016640;D057220;D063731;D017216 | T058;T047;T041;T170 |
36,240,007 | viscos nanoconfin branch chain fatti acid studi reson shear measur lubric perform improv use addit organ friction modifi ofm influenc conform properti space confin substrat surfac render detail properti analysi confin ofm lubric matter high practic signific date studi fatti acid confin ofm main focus linear unsatur chain molecul leav branch chain structur underexplor bridg gap use reson shear measur studi probe viscos two branch chain c fatti acid isostear acid isostear acid confin mica surfac differ appli normal load l surfac separ distanc viscos paramet b acid signific increas mn revers bulk viscos order nanoconfin ascrib abil bulki methyl substitut side chain isostear acid prevent order nanospac mica surfac thus preserv fluidlik properti obtain result provid fundament insight lubric branch chain fatti acid expect promot develop novel high perform ofm | D005227;D000538 | T109;T123;T168;T197 |
36,240,003 | secur collabor platform health care research open environ perspect account access control recent use health care varieti ehealth data increas collect store nation health agenc ehealth data advanc modern health care system make smarter mani research want use data studi howev use ehealth data bring privaci secur concern analyt environ support health care research must also consid mani requir reason countri general provid research platform health care data provid eg patient still concern secur privaci ehealth data thus secur platform health care research guarante util ehealth data focus secur privaci need | D000081186;D016494 | T066;T078;T057;T170;T097;T080 |
36,240,001 | digit mental health intervent depress scope review user engag mani digit mental health intervent dmhis found efficaci patient engag dmhis increas emerg concern implement real world clinic set address engag must first understand standard engag level context random control trial rcts compar treatment | D008603;D063731 | T041;T170 |
36,239,999 | effect supervis machin learn screen diagnos voic disord systemat review meta analysi investig voic disord seri process use includ voic screen diagnosi method limit standard test affect clinician experi subject judgment machin learn ml algorithm use object tool screen diagnos voic disord howev effect ml algorithm assess diagnos voic disord receiv suffici scholar attent | D000069553;D014832 | T047;T066;T033 |
36,239,996 | assembl increas larg ln contain polyoxoniob intermolecular aggreg disaggreg interconvers oxal assist lanthanid ln incorpor strategi first demonstr creat rare high nuclear ln contain polyoxoniob ponb strategi seri high nuclear ln contain ponb nuclear dy nb nuclear dy nb nuclear dy nb nuclear dy nb made show increas larg structur evolut dy nb monom dy nb dimer distinct dy nb dy nb tetram among dy nb present largest heterometal ponb also ponb greatest number ln ion report thus far interest giant dy nb dy nb molecul undergo singl crystal singl crystal intermolecular aggreg form infinit dy nb dy nb chain respect former structur transform show revers humid depend aggreg disaggreg process accompani proton conduct respons latter structur transform irrevers new speci larg enrich limit member ln contain ponb famili offer rare exampl studi structur transform giant molecular aggreg infinit extend structur atom level | D028581 | T196 |
36,239,991 | pilot influenza syndrom surveil system base absente temperatur china develop usabl studi shortcom current school base infecti diseas syndrom surveil system sss china includ reli school physician collect data manual ignor health inform student attend | D000041;D007251 | T055;T047 |
36,239,988 | disrupt schizophrenia requir normal pyramid cell interneuron communic assembl dynam prefront cortex interrog prefront circuit function mice lack disrupt schizophrenia disc mutant mice risk factor psychiatr disord singl unit record awak mice reveal reduc averag fire rate fast spike interneuron int includ optogenet identifi parvalbumin posit cell lower proport int phase coupl ongo gamma oscil moreov observ decreas spike transmiss efficaci local pyramid cell pyr int connect vivo suggest reduc excitatori effect local glutamaterg input potenti mechan lower int rate network level impair int function result alter activ pyr assembl assembl activ defin coactiv within ms observ equal often express strength individu assembl pattern signific higher disc mutant mice data thus reveal role disc shape properti prefront assembl pattern set int respons glutamaterg drive | D010320;D012559 | T123;T116;T048 |
36,239,985 | predict regioselect ao cyp fmo ugt metabol use quantum mechan simul machin learn unexpect metabol modif conjug phase lead failur mani late stage drug candid even withdraw approv drug thus critic predict site metabol som enzym interact drug like molecul earli stage research studi present method predict isoform specif metabol human ao fmos ugt general cyp metabol preclin speci model use semi empir quantum mechan simul valid use experiment obtain data dft calcul estim reactiv som context whole molecul ligand base model train test use high qualiti regioselect data combin reactiv potenti som orient steric effect bind pocket differ enzym isoform result model achiev valu auc | D000069550 | T066 |
36,239,981 | genom architectur pregnanc associ plastic matern mous hippocampus pregnanc associ extraordinari plastic matern brain studi human mammal suggest extens structur function remodel femal brain pregnanc howev understand remark littl molecular underpin natur phenomenon gain insight pregnanc associ hippocamp plastic perform singl nucleus rna sequenc snrna seq snatac seq mous hippocampus pregnanc identifi cell type specif transcript epigenet signatur associ pregnanc postpartum adapt addit analyz receptor ligand interact transcript factor tf motif inform hippocamp cell type ident provid evid pregnanc associ adapt total data provid uniqu resourc coupl transcript epigenet data across dynam time period mous hippocampus suggest opportun function interrog hormon mediat plastic | D023281;D006624 | T026;T091;T023 |
36,239,975 | choroid thick earli postnat guinea pig predict subsequ natur occur form depriv myopia identifi choroid characterist associ suscept develop natur occur experiment induc myopia | D009216;D012030 | T047 |
36,239,974 | optic nerv head myelin relat protein gfap iba alter non human primat earli moder experiment glaucoma purpos studi test optic nerv head onh myelin basic protein mbp cyclic nucleotid phosphodiesteras cnpase glial fibrillari acid protein gfap ioniz calcium bind adaptor molecul iba protein alter non human primat nhp earlymoder experiment glaucoma eg | D005901;D009898 | T047;T023;T033 |
36,239,972 | programm shape probe proxim bival recognit rapid electrochemiluminesc respons acut myocardi infarct herein exogen luminophor free dispos electrochemiluminesc ecl biosensor establish rapid respons acut myocardi infarct ami use programm shape probe probe proxim bival recognit specif indium tin oxid thin film coat glass electrod ito modifi urchin like porous tio microspher ptio mss could achiev strong stabl ecl solut due dual promot effect coreact acceler ptio mss exhibit fold higher ecl intens comparison bare ito moreov probe bival recognit element contain two kind cardiac troponin ctni biomark ami aptam linker label ferrocen l fc design export signal mode target ctni proxim probe l fc separ electrod surfac due proxim recognit ctni aptam achiev high effect recoveri ecl allow much rapid detect ctni sandwich type immunoassay proof concept exogen luminophor free dispos ecl platform rapid sensit monitor ctni obtain display desir linear rang fg ml ng ml limit detect lod fg ml ingeni expand portabl home tester ecl biosensor develop | D015374;D009203 | T059;T047;T075 |
36,239,969 | trend associ diabet cardiovascular event studi use administr health care data ontario canada assess whether chang diabet manag practic affect trend associ diabet vs prior cardiovascular diseas risk cardiovascular event among adult age year | D003920;D002318 | T047 |
36,239,967 | topograph relationship choroid microvascular dropout glaucomat damag primari angl closur glaucoma studi topograph relationship parapapillari choroid microvasculatur dropout mvd parapapillari retin nerv fiber layer rnfl defect primari angl closur glaucoma pacg eye | D005901;D015812;D005902;D009898 | T047;T023;T033 |
36,239,966 | character retin microvasculatur faz chang ischem stroke differ type studi aim assess morpholog chang retin microvasculatur foveal avascular zone faz patient ischem stroke differ subtyp | D000083242;D059409 | T047 |
36,239,965 | situ form collagen hyaluron semi interpenetr network hydrogel enhanc corneal defect repair million worldwid suffer vision impair blind corneal injuri remain urgent need effect access way treat corneal defect design character situ form semi interpenetr polym network sipn hydrogel use biomateri wide use ophthalmolog medicin | D065306;D020100 | T122;T037;T033 |
36,239,964 | impact age len posterior capsular opacif quantit autofluoresc imag age relat macular degener purpos studi investig quantit autofluoresc qaf patient without earli intermedi age relat macular degener amd determin impact age crystallin len posterior capsular opacif pco | D058442;D007908;D008268 | T047;T023 |
36,239,956 | trend geograph dispar access ambulatori surgeri center new york cross section analysi evalu trend densiti volum util ambulatori surgeri center neighborhood socioeconom status | D000556;D054625 | T061;T080 |
36,239,955 | effect person outreach medicaid marketplac coverag transit random clinic trial random clinic trial examin effect email remind person telephon outreach combin afford care act enrol among household recent lost medicaid becam elig subsid marketplac coverag california | D062265;D008484 | T058;T089;T064 |
36,239,954 | associ health insur geographi race ethnic dispar receipt recommend postpartum care us littl known qualiti postpartum care dispar content postpartum care associ health insur rural urban resid race ethnic | D005006;D011181 | T098;T058;T102 |
36,239,953 | dispar spatial access emerg surgic servic us hospit emerg surgic servic provid essenti care wide rang time sensit diseas common use measur spatial access distanc travel time shown underestim dispar compar comprehens metric | D005006;D054625 | T098;T102;T080 |
36,239,943 | sexual transmit infect rate closur famili plan clinic abort restrict iowa cohort studi assess rate sexual transmit infect iowa counti closur famili plan health center compar nation rate | D000028;D000022;D012749 | T093;T046;T047;T061;T081;T033 |
36,239,942 | preval onlin sexual offens children us sexual abus increas facilit technolog preval dynam offens well delin make difficult design prevent strategi | D002650;D017406 | T054;T048 |
36,239,941 | associ thrombectomi function outcom patient ischem stroke present extend time window extens sign infarct limit data avail potenti benefit associ endovascular treatment evt patient ischem stroke present extend time window also show sign extens infarct | D002545;D057510;D000083242;D020521 | T061;T047;T046 |
36,239,940 | associ neighborhood condit resourc children life expect birth us address inequ life expect must understand associ modifi socioeconom structur factor life expect howev associ limit neighborhood resourc deleteri physic condit life expect well understood | D008017;D012111 | T068;T081;T083;T082;T078;T102;T056;T096;T033 |
36,239,939 | particip older adult clinic trial new drug applic biolog licens applic older age may accompani chang pharmacokinet pharmacodynam medic result alter safeti efficaci profil | D001688;D002986;D010358 | T058;T081;T121;T123;T062;T080 |
36,239,938 | associ prediagnosi obes postdiagnosi aspirin surviv stage iv colorect cancer potenti relationship obes colorect cancer crc outcom poor understood patient late stage diseas increas bodi mass index may negat aspirin use cancer prevent role factor effect postdiagnosi aspirin use unclear | D001241;D015179 | T121;T109;T191 |
36,239,937 | associ time interv covid vaccin vitro fertil pregnanc rate fresh embryo transfer lack inform regard need postpon concept covid vaccin | D000086382;D000086663 | T047;T200;T067 |
36,239,936 | classif high grade serous ovarian cancer use tumor morpholog characterist despit similar histolog appear among high grade serous ovarian cancer hgsoc clinic observ suggest vast differ gross appear current systemat framework classifi hgsoc accord gross morpholog characterist | D010051 | T191 |
36,239,935 | incid surviv synchron metachron liver metastas colorect cancer although treatment prognosi synchron liver metastas colorect cancer relat well known compar descript incid epidemiolog featur outcom synchron metachron liver metastas lack differ prognosi patient synchron metachron liver metastas controversi | D015179;D008113;D016609 | T191 |
36,239,934 | estim protect prior sar cov infect reinfect omicron variant among messeng rna vaccin nonvaccin individu quebec canada omicron variant phylogenet antigen distinct earlier sar cov variant origin vaccin strain protect confer prior sar cov infect omicron reinfect without vaccin requir quantif | D000086382;D014765 | T121;T047;T067;T129 |
36,239,933 | young onset breast cancer outcom time sinc recent childbirth utah breast cancer diagnos within year childbirth call postpartum breast cancer ppbc associ increas risk metastasi death whether postpartum diagnosi independ risk factor surrog marker cancer featur associ poor outcom remain understudi | D001943 | T191 |
36,239,914 | effect food pharmacokinet senaparib imp healthi chines subject data effect food pharmacokinet senaparib previous imp oral poli adenosin diphosph ribos polymeras inhibitor limit studi conduct evalu effect food pharmacokinet senaparib healthi chines subject | D018565 | T046;T070 |
36,239,913 | effect simvastatin versus gemfibrozil primari prevent cardiovascular event retrospect cohort studi primari care patient evid effect statin compar fibrat primari prevent cardiovascular event limit therefor assess compar effect simvastatin versus gemfibrozil primari prevent major advers cardiovascular event mace mortal | D015248;D003327 | T121;T047;T109 |
36,239,902 | hidden burden diseas treatment experi patient essenti tremor retrospect claim data analysi essenti tremor et affect approxim million peopl usa yet public recognit diseas impact remain low | D020329 | T047 |
36,239,895 | quantit evalu method smoke exhaust perform applic exhaust volum optim tunnel fire later central mode studi investig indic quantit method evalu smoke exhaust perform provid theoret basi optim smoke extract system later central mode tunnel fire criterion propos plug hole theoret model smoke exhaust effici establish distinguish whether plug hole occur relationship effici effect efficaci analyz perspect smoke heat exhaust meanwhil evalu method appli optim exhaust volum practic engin fds numer simul result show ri vital basi reflect movement form smoke exhaust effect critic valu ri plug hole occur standard three lane immers tunnel result signific reduct effici smoke exhaust greater exhaust volum exhaust fan greater ri valu higher total smoke heat exhaust effici better exhaust effect smoke inlet without plug hole longitudin ventil optim exhaust volum mw mw applic case | D012906;D005390 | T131;T067 |
36,239,866 | osteopontin promot infarct repair understand macrophag promot myocardi repair help creat new therapi infarct repair aim determin mechan underli repar properti macrophag cytokin array reveal neonat cardiac macrophag injur neonat heart secret high amount osteopontin opn vitro recombin opn stimul cardiac cell outgrowth cardiomyocyt cm cell cycl entri cm migrat addit opn induc nuclear transloc cytoplasmat yes associ protein yap upregul transcript factor cell cycl gene signific block opn receptor cd elimin effect opn cms opn also activ prolifer migrat non cm cell endotheli cell cardiac mesenchym stromal cell vitro notabl signific role opn myocardi heal demonstr impair heal opn defici neonat heart final adult mice singl inject opn border ischem zone induc cm cell cycl entri improv scar format local global cardiac function lv remodel day mi summari shown first time recombin opn activ cell cycl entri cms addit recombin opn stimul multipl cardiac cell improv scar format lv remodel region global function mi therefor propos opn new cell free therapi optim infarct repair | D009203;D053495 | T047;T123;T116 |
36,239,864 | breast cancer among african american sub saharan african women tale global inequ breast cancer common femal cancer worldwid signific global dispar particular disadvantag women african ancestri though unit state sub saharan africa seem differ set mani import parallel experi get diagnos treat breast cancer two geograph region women african ancestri commentari explor parallel differ propos agenda move forward narrow dispar gap world vulner women | D001741;D001943 | T098;T191 |
36,239,863 | nmr base metabol profil children prematur adrenarch prematur adrenarch pa long time consid benign condit later connect various diseas childhood adulthood remain controversi | D050499 | T123 |
36,239,860 | construct wetland remov pharmaceut person care product ppcps wastewat origin impact treatment method swot analysi continu exposur pharmaceut person care product lead seri individu antagonist synergist effect long last toxic human aquat live may also lead develop antibiot resist teratogen carcinogen endocrin disrupt effect howev sever ppcps also consid biolog activ non target aquat organ mosquito fish goldfish alga pseudokirchneriella subcapitata various physicochem method ozon photolysi membran separ recogn effect remov ppcps howev high oper mainten cost associ ecolog impact limit use construct wetland consid eco friend sustain remov pharmaceut person care product togeth antibiot resist gene sever mechan sorption biodegrad oxid photodegrad volatil hydrolysi occur phytoremedi ppcps process ppcps elimin construct wetland also offer sever addit benefit obtain macrophyt biomass may use raw materi pulp paper industri sourc second generat biofuel product studi discuss origin impact ppcps togeth treatment method also investig strength weak opportun threat associ construct wetland treatment wastewat laden pharmaceut person care product | D003358;D010126;D014874 | T103;T167;T131;T073 |
36,239,856 | increas risk venous thromboembol among patient famili mediterranean fever famili mediterranean fever fmf auto inflammatori diseas character acut febril attack seros arthriti skin rash previous studi identifi associ venous thromboembol vte various inflammatori autoimmun disord driven larg part inflammatori process despit establish associ remain pauciti data link fmf vte purpos studi evalu associ vte patient fmf compar match control | D010505;D054556 | T047 |
36,239,851 | halorussus valli sp nov halorussus aquaticus sp nov halorussus gelatinilyticus sp nov halorussus limi sp nov halorussus salilacus sp nov halorussus salinisoli sp nov six extrem halophil archaea isol solar saltern salt lake salin soil six novel halophil archaeal strain xzyjt xzyj xzyjt xzyjt ycn lt isol solar saltern tibet salt lake shanxi salin soil xinjiang china sequenc similar rrna rpob gene among strain xzyjt xzyj xzyjt xzyjt ycn lt current member halorussus respect averag nucleotid ident silico dna dna hybrid valu among six strain current halorussus member rang respect valu speci boundari threshold valu phylogenom tree base conserv archaeal protein marker gene reveal six novel strain form individu distinct branch cluster tight halorussus member sever phenotyp characterist distinguish six strain current halorussus member polar lipid analysi show six novel strain contain phosphatidylglycerol phosphatidylglycerol phosphat methyl ester phosphatidylglycerol sulfat two three glycolipid phenotyp chemotaxonom phylogenet properti show six strain repres six novel speci within genus halorussus name halorussus valli sp nov halorussus aquaticus sp nov halorussus gelatinilyticus sp nov halorussus limi sp nov halorussus salilacus sp nov halorussus salinisoli sp nov propos | D006216;D060106 | T083;T194;T070 |
36,239,847 | valid intens care unit data mart research qualiti improv data deriv electron health record ehr frequent extract use undefin approach may affect accuraci collect variabl effort assess data accuraci often suffer limit collabor clinician data analyst perform extract manuscript describ methodolog behind creation structur rigor deriv intens care unit icu data mart base data automat routin deriv ehr icu data mart includ high qualiti data element common use qualiti improv research purpos data element identifi physician work close data analyst iter develop refin algorithm definit complex outcom risk factor contend methodolog reproduc appli across institut clinic domain creat high qualiti data mart inclus complex outcom data | D000073458;D058996 | T170;T057 |
36,239,843 | sustain groundwat manag optim water suppli system use coupl simul optim approach meet peopl water suppli need citi urgent challeng especi coastal citi surfac water sourc usual inadequ groundwat frequent exploit result rapid decreas intrus saltwat conjunct use surfac water groundwat best altern approach mitig overus groundwat effect distribut surfac water sourc requir numer run simul optim model select optim pattern water distribut keep groundwat level control studi new simul optim model develop use wavelet support vector regress wsvr genet algorithm ga propos optim water distribut system visakhapatnam citi east coast india fulfil constraint surfac water quantiti aquif pump drawdown estim groundwat pump groundwat level variat spatial context challeng urban environ overcom calibr modular finit differ flow modflow model studi area use prepar spatial tempor variat model input groundwat pump groundwat level wsvr ga model perform reduc groundwat pump evalu three distinct case surfac water resourc three sourc distribut differ ward citi sourc wise case central case ii iii sourc wise surfac water constraint limit month case ii annual case iii wsvr ga manag model suggest ward wise groundwat pump restrict result mcm mcm mcm increas total groundwat storag capac case ii iii respect case ii iii offer respect storag case thus central distribut system increas sustain groundwat suppli prevent overdraft caus lack surfac water resourc valid result use modflow indic substanti rise groundwat level studi area | D060587;D014867 | T081;T082;T121;T197;T070 |
36,239,841 | cellular senesc obes associ complic new therapeut target obes increas worldwid recent repres major global health challeng review focus obes associ cellular senesc various organ role senesc cell sncs drive complic associ obes also abil target sncs pharmacolog drug term senotherapeut therapi complic discuss | D000975;D000089322 | T121;T044;T123;T039 |
36,239,840 | oncolog safeti axillari lymph node dissect immedi lymphat reconstruct immedi lymphat reconstruct ilr time axillari lymph node dissect alnd reduc incid lymphedema patient breast cancer oncolog safeti ilr unknown report purpos studi evalu ilr associ increas breast cancer recurr rate | D001943 | T191 |
36,239,836 | pre oper mri radiom model non invas predict key genom marker surviv glioblastoma patient although glioblastoma gbm common primari brain malign tool exist pre oper risk stratifi patient overal surviv os common genet alter develop mri base radiom model identifi patient egfr amplif mgmt methyl gbm subtyp os greater month | D005909;D001932 | T191 |
36,239,825 | trend threshold bacteri degrad bisphenol endocrin disruptor concis review bisphenol bpa monom found polycarbon plastic food can everyday chemic monom counterpart wide use culmin presenc water soil sediment atmospher furthermor estrogen genotox properti acknowledg endocrin disruptor contamin bpa environ becom grow concern way effect mitig bpa environ current explor henc focal point review collat bacteri degrad bpa propos degrad mechan explicit focus research publish bpa breakdown depend primarili bacteri metabol although numer factor influenc fate environ metabol rout bpa breakdown crucial bacteri strain postul sourc transform metabolit intermedi perceiv degrad enzym gene associ bacteri degrad bpa also includ review review moment generat conceptu strategi stimul progress bacteri mitig bpa path sustain cleaner environ | D052244 | T131;T039 |
36,239,815 | assess drought trend variabl agricultur domin marathwada region india drought consid among peril event catastroph consequ particular agro econom point view consequ expect exacerb increas meteorolog aberr due chang climat necessit investig drought variabl studi present thorough spatiotempor assess drought trend variabl agricultur domin marathwada region maharashtra india precipit data extract india meteorolog depart imd grid product wherea actual evapotranspir et evapor stress index esi obtain global land evapor amsterdam model gleam dataset standard precipit index spi use character drought occurr multipl time frame wherea non parametr test ie modifi mann kendal mmk sen slope ss test employ detect trend result reveal region prone drought spi longer time frame ie month move frame captur drought occurr better shorter time frame attribut lesser random time seri longer frame mix positiveneg trend spi seri found monsoon month howev relat concentr toward negat z mmk henc marathwada region infer exhibit relat increas tendenc toward drought occurr season differ mean valu trend rainfal et esi discuss detail sinc marathwada region monsoon domin climat high agricultur import inform report studi help devis water manag strategi minim repercuss drought | D055864;D004784 | T057;T070 |
36,239,813 | exist novel heavi metal toler pseudomona aeruginosa strain zambia szk kabw potenti bioremedi agent heavi metal contamin area bacteri biomass may serv import environment clean agent toxic heavi metal ion expens chemic process environment friend studi aim character bacteri agent could serv potenti situ bioremedi agent site isol character perform use phenotyp molecular approach novel pseudomona aeruginosa strain pseudomona aeruginosa zambia szk kabw success isol identifi character strain show promis toler heavi metal copper mm zinc nickel mm cobalt mm cadmium mm laboratori level bacterium shown bioaccumul least copper ii sulfat mgl r cadmium ii chlorid mgl r zinc ii chlorid mgl r nickel ii chlorid mgl r cobalt ii chlorid mgl r highest bioaccumul observ heavi metal cadmium zinc nickel cobalt character bacterium ph reveal high ph lower ph bacterium tend reduc growth optimum growth ph high temperatur around c negat effect growth perform bacterium optimum growth observ c novel p aeruginosa strain shown phenotyp attribut becom potenti bioremedi agent howev investig need done understand gene molecular mechan drive toler multipl heavi metal | D019216;D011550 | T007;T196 |
36,239,804 | european research cradl discoveri antidiabet hormon pioneer role relev oskar minkowski eugn gley introduct hormon treatment sever diabet repres clinic social impact similar antibiot therapi octob assembl karolinska institut decid award nobel prize physiolog medicin canadian frederick grant bant scottish john jame rickard macleod research univers toronto ut discoveri insulin year week later european american research protest decis controversi remain day | D007328;D005934 | T121;T116;T125 |
36,239,799 | heterogen dose distribut normal tissu case radiopharmaceut therapi alpha emit radionuclid heterogen dose distribut shown differ spatial scale diagnost nuclear medicin cancer treatment use new radiopharmaceut alpha particl emitt shown extens degre dose heterogen affect tumour control toxic organ risk review aim provid overview general intern dosimetri nuclear medicin highlight need consider dose heterogen within organ risk current method use patient dosimetri radiopharmaceut therapi summar bio distribut dose heterogen alpha particl emit pharmaceut ra xofigo within bone tissu present exampl line strateg research agenda multidisciplinari european low dose initi melodi european radiat dosimetri group eurado futur research direct pharmacokinet model dosimetri patient radiopharmaceut therapi recommend | D019275;D009369 | T121;T130;T191 |
36,239,769 | rare diseas digit nation action leagu peopl rare diseas nams peopl rare diseas face specif challeng within healthcar system due rariti individu diseas medic care research made difficult structur medic econom reason nation action leagu peopl rare diseas nams found german feder ministri health german feder ministri educ research allianc chronic rare diseas well partner sinc nams central coordin communic platform peopl rare diseas germani aim improv health qualiti life affecteda part consensus process nams formul requir regard digit german healthcar system requir aim toward connect healthcar institut generat knowledg research purpos improv flow inform main object collect secur health data space interoper clinic inform system uniform semant standard precis code rare diseas particular importancein come year import process alreadi initi must design support interest peopl rare diseas includ german genom initi genomd implement electron patient record activ toward european health data space order divers initi project mesh clear object requir part overal digit concept nams make import contribut | D035583;D011788 | T078;T047 |
36,239,768 | uncov rare diseas medic data code icd gm code system use german healthcar system captur minor rare diseas diagnos therefor inform incid preval rare diseas well necessari financi resourc expert care requir evid base decis health insur care provid politician lack furthermor miss inform complic sometim even preclud generat scientif knowledg rare diseas therefor start patient case germani rare diseas diagnosi must code orphacod use alpha id se fileth file alpha id se link icd gm code intern establish orphacod rare diseas commerci avail softwar tool progress support code rare diseas sever center rare diseas link univers hospit tool procedur establish realiz complet code rare diseas includ financi incent institut provid rare diseas code systemat queri ask rare diseas code code process semi autom code process patient rare diseas previous seen institut combin differ approach probabl result complet codingto get complet pictur rare diseas epidemiolog care requir specif uniqu code patient case also desir furthermor structur report phenotyp requir especi complex rare diseas yet undiagnos case | D035583;D038801 | T047;T170 |
36,239,750 | twig like middl cerebr arteri case neurofibromatosi type neurofibromatosi type nf autosom domin genet disord multisystem involv affect central nervous system skin bone system vessel heterogen clinic present vascular abnorm typic recogn neurofibromatosi type affect cardiovascular cerebrovascular system incid circl willi anomali children nf twofold higher general popul paper report year old femal nf twig like middl cerebr arteri | D009456 | T191;T047 |
36,239,749 | robust molecular imprint electrochemiluminesc sensor base ni co nanoarray sensit detect spiramycin prepar portabl robust sensor sensit select detect small molecul still challeng studi electroanalyt sensor develop molecular imprint electrochemiluminesc sensor miecl detect spiramycin spi type multi compon macrolid antibiot first ni co ldh nanoarray synthes one step hydrotherm method direct use sens platform synthes n ti c modifi nanoarray due function nanomateri n ti c serv substrat materi enabl load larg amount perylen tetracarboxyl acid ptca also act co reaction promot acceler decomposit generat modifi nanoarray display signific enhanc electrochemiluminesc ecl signal final molecular imprint polym mip ecl techniqu combin great improv select sensit sensor optim condit easili construct miecl sensor show good select reproduc stabil detect limit fabric sensor evalu appli detect spi milk sampl | D054802;D015572;D049329;D015374 | T073;T059;T063;T195;T109;T075 |
36,239,748 | determin ureter obstruct percutan nephrolithotomi ureter obstruct percutan nephrolithotomi pcnl may requir prolong drainag nephrostomi tube nt ureter stent well understood occur goal studi identifi risk factor associ postop ureter obstruct help guid drainag tube select | D000074642;D014517;D009403;D007669;D053039 | T061;T047 |
36,239,740 | explor stop signal reaction time two session anticipatori respons inhibit task various behaviour task measur respons inhibit encompass abil cancel unwant action evalu via stop signal reaction time ssrt unclear whether ssrt unchang inher measur inhibitori network integr whether improv repetit current studi explor ssrt chang two session anticipatori respons inhibit task arit compar stop signal task sst forti four particip repeat arit sst two session ssrt constitu measur go trial reaction time stop signal delay calcul ssrt reflect non select respons inhibit consist session arit sst p reaction time stop signal delay also remain stabl across session arit p wherea sst reaction time p stop signal delay p increas ssrt reflect behaviour select stop arit improv p two session underpin chang reaction time p stop signal delay p overal maxim effici non select inhibit remain stabl across two session arit result sst confirm non select inhibit howev affect inhibitori network integr behaviour select stop arit chang across session suggest sequenti neural process captur ssrt occur quick session two find implic futur studi necessit behaviour measur multipl session | D007266 | T041 |
36,239,739 | thoracoscop right segmentectomi altern posterior approach individu basal segmentectomi particular challeng author previous use anterior approach perform segmentectomi howev find posterior approach allow direct access vein bronchus aid divid posterior portion intersegment plane trunk inferior pulmonari vein becom conveni landmark hug delin segment bronchus cours posterior author current favor approach segmentectomi cross section imag andor dimension reconstruct essenti delin anatom relationship particular relationship vein branch may vari bronchus also use locat segment arteri typic lie deep bronchus imag use tool preoper plan guid oper dissect regardless approach remain difficult segmentectomi great care requir dissect divid delic bronchovascular structur locat deep within oper field | D008175;D011013 | T191;T061 |
36,239,736 | system therapi metastat hormon sensit prostat cancer landscap metastat hormon sensit prostat cancer mhspc evolv rapid recent year new data landmark trial support upfront treatment intensif develop come front system agent also area therapi primari tumour metastas | D000726;D011471 | T121;T039;T191 |
36,239,735 | comprehens review various approach treatment tertiari wastewat emerg contamin know last decad environment contamin ec introduc environ alarm rate risk human health aquat ecosystem trace level emerg contamin includ hospit wastewat hpww cosmet person care product endocrin system disruptor transform product despit fact pollut introduc detect relat recent inform characterist action impact limit technolog elimin effici wastewat recycl system capabl provid irrig water crop municip sewag treatment remov ec wastewat reus essenti water treatment process contain advanc ion biotic origin ec biotic origin high recommend contamin studi introduc fundament treatment tertiari wastewat includ membran filtrat uv ultraviolet irradi ozon chlorin advanc oxid process activ carbon ac alga next detail descript recent develop innov compon emerg contamin remov process provid | D003358;D052244;D010126;D014874;D018508 | T073;T052;T167;T131;T057;T103;T039 |
36,239,734 | understand extracellular vesicl surfac clinic molecular biolog extracellular vesicl ev lipid membran enclos nanoparticl play signific role health diseas ev abund bodi fluid carri array molecul protein lipid nucleic acid glycan reflect ident activ cell origin advent high throughput omic technolog allow depth characteris ev composit molecular speci spatial distribut within ev structur well appreci particular true ev surfac plethora molecul report integr peripher associ ev membran coron layer atmospher surround ev membran contribut larg high interact dynam surfac area respons facilit ev interact extracellular environ ev coron layer harbour surfac molecul reflect ident parent cell like high valuabl properti context diagnost liquid biopsi review describ current understand mechan electrostat molecular properti ev surfac offer signific biomark potenti contribut high dynam interactom | D000067128;D009696 | T026;T123;T114 |
36,239,715 | select immunocaptur reveal neoplast human mast cell secret distinct microvesicl exosom like popul kit contain extracellular vesicl activ mutat receptor kit promot dysregul prolifer human mast cell humc result neoplast humc secret extracellular vesicl ev transfer oncogen kit among cargo recipi cell despit potenti contribut diseas kit contain ev thorough investig isol character kit ev subpopul releas neoplast humc use immunocaptur approach select isol ev contain kit proper topolog immunocaptur ev kit antibodi coat electron microscopi em affin grid allow assess morpholog size kit ev immunoblot analysi demonstr kit ev distinct protein profil kit deplet ev contain exosom microvesicl marker separ subtyp ultracentrifug cell treatment sphingomyelinas inhibitor shift protein content among kit ev subtyp suggest differ biogenesi rout proteom analysi reveal humc kit ev enrich protein involv signal immun respons cell migrat suggest divers biolog function indic neoplast humc dissemin kit via shuttl heterogen microvesicl exosom like ev select kit immunocaptur enabl enrich specif humc deriv ev complex human biosampl facilit understand vivo function potenti serv biomark specif biolog patholog | D055354;D000067128 | T026 |
36,239,713 | critic review front load maladapt drink pattern driven alcohol reward effect front load drink pattern alcohol intak skew toward onset reward access phenomenon report across sever differ alcohol self administr protocol wide varieti speci includ human hypothesi current review front load emerg respons reward effect alcohol use measur motiv consum alcohol altern addit hypothes consid contrast main hypothesi front load direct overcom behavior andor metabol toler front load driven negat reinforc evid explan review also consid front load evalu statist previous research make recommend defin intak pattern futur studi front load may predict long term maladapt alcohol drink pattern lead develop alcohol use disord aud sever futur direct propos elucid relationship front load aud | D012201;D000437 | T041;T048 |
36,239,712 | rapid product method increas yield high puriti extracellular vesicl obtain use extend mitochondri target domain peptid extracellular vesicl ev nano size membran structur involv intercellular communic various physiolog patholog process present novel method rapid within min larg scale product high puriti ev use emtd peptid deriv noxa treatment mesenchym stem cell deriv human wharton jelli trypsin subsequ emtd stimul chemic defin sucros buffer orbit shake led substanti increas approxim fold ev product mark high puriti approxim fold ev ts eev show higher regen immunomodulatori potenti natur ev obtain cultur media h calcium chelat bapta calpain inhibitor allm natur ev biogenesi inhibitor gw block ts eev product induc emtd indic emtd mediat regul intracellular calcium level calpain activ close associ rapid mass product ts eev present studi may lead consider advanc ev base drug develop product stem cell deriv ev cell therapi | D002154;D000067128 | T126;T026;T123;T116 |
36,239,711 | rapid reliabl tripl emiss detect dichloro nitroanilin pesticid base high nuclear cd ii sm iii nanoclust luminesc metal cd ii sm iii nanoclust molecular size nm construct flexibl schiff base ligand crystal structur determin use x ray diffract method show rapid tripl emiss respons dichloro nitroanilin dcn common pesticid high sensit select use quantit analyz dcn concentr fruit extract limit detect lod dcn visibl ligand center sm iii emiss nir sm iii luminesc | D010575 | T131 |
36,239,706 | fate biolog impact persist luminesc nanoparticl inject mice one year follow persist luminesc nanoparticl plnps attract grow interest non invas optic imag tissu high signal nois ratio plnps emit persist luminesc signal tissu transpar window sever minut uv light excit system administr direct vivo visibl irradi allow us get rid autofluoresc signal tissu plnps constitut promis altern commerci avail optic near infrar probe thank versatil function capabl improv circul time blood stream nevertheless biodistribut short time well known long term fate toxic plnp inorgan core inject dealt depth extend current knowledg znga cr nps zgo one year follow fate singl system administr mice investig organ tissu uptak zgo two differ coat determin intracellular process one year inject biopersist zgo assess long term retent quantifi icp ms most liver spleen parallel loss luminesc properti analysi toxic relat combin anim weight key hematolog metabol marker histolog observ liver tissu quantif express gene link differ metabol reaction reveal sign noxious macro scale molecular level therefor zgo imag probe proven safe relev candid preclin studi allow long term use without vivo disturb general metabol | D049449;D053758 | T073;T070 |
36,239,702 | efficaci safeti midazolam fentanyl versus midazolam ketamin bedsid invas procedur sedat pediatr oncolog patient random doubl blind crossov trial children cancer often requir sedat undergo invas procedur fentanyl ketamin midazolam effect drug wide use procedur sedat studi aim investig efficaci safeti midazolam fentanyl f compar midazolam ketamin k bedsid procedur sedat among pediatr oncolog patient random doubl blind crossov trial conduct among children cancer requir procedur sedat invas procedur patient random assign either intraven f k subsequ receiv altern regimen follow crossov design studi efficaci safeti sedat includ sedat time interv nausea score vomit episod pain score advers effect parent satisfact evalu patient procedur sedat enrol k provid shorter induct time vs min p longer sedat vs min p emerg time vs min p compar f sedat rout affect sedat time interv patient higher rate vomit rang vs rang p experienc less pain vs p k group overal satisfact advers effect compar among sedat regimen combin sedat drug recommend improv effect bedsid procedur sedat k provid shorter induct longer sedat emerg time compar f find correl sedat rout patient receiv k experienc higher rate vomit less pain compar f overal satisfact toler side effect compar among sedat regimen | D007649;D009369 | T121;T109;T191 |
36,239,700 | inert dens region newli discov protein help defin subset heterochromatin region silenc harm mobil genet element genom fruit fli | D029721;D006570 | T026;T123;T116 |
36,239,699 | earli immun marker clinic virolog immunolog outcom patient covid multi omic studi great major sever acut respiratori syndrom relat coronavirus sar cov infect mild uncompl individu initi mild covid progress develop sever symptom furthermor substanti heterogen sar cov specif memori immun respons follow infect remain critic need identifi host immun biomark predict clinic immunolog outcom sar cov infect patient | D000086382 | T047;T067 |
36,239,698 | fuel dna self assembl via gel releas regul develop respons multicompon molecular materi requir mean physic separ yet easili coupl distinct process demonstr method use molecul reaction load microlit size polyacrylamid hydrogel mini gel control dynam self assembl dna nanotub first character uv mediat releas dna molecul mini gel chang diffus rate minim spontan leakag dna demonstr mini gel use compart storag releas dna mediat assembl disassembl dna nanotub one pot process speed dna releas control mini gel poros approach achiev control assembl disassembl nanotub distinct kinet includ finit delay obtain load distinct dna regul distinct mini gel final show mini gel also host local enzymat reaction transcrib rna regul synthet gene load mini gel diffus rna aqueous phase result activ self assembl experiment data recapitul mathemat model describ diffus dna molecul gel phase aqueous phase control self assembl nanotub look forward dna load mini gel may miniatur pattern build sophist storag compart use within multicompon complex biomolecular materi relev biomed applic artifici life | D004247;D043942 | T123;T073;T114 |
36,239,696 | proof concept studi secondari structur influenza b mer sar cov e transmembran peptid use fold molecular dynam simul membran mimet solvent carri proof concept molecular dynam md simul adapt temper membran mimet environ studi fold singl pass membran peptid test influenza viroporin influenza b viroporin protein e coronavirus mer cov sar cov peptid known experiment secondari structur membran bilay two influenza deriv peptid signific differ peptid sequenc secondari structur polar two coronavirus deriv peptid total simul time could accomplish trifluoroethanol tfe membran model character compar fold behavior helic stabil helic propens transmembran peptid match perfect experiment secondari structur identifi common motif reflect quaternari organ known biochem function show bm organ two structur distinct part signific stabl n termin half fast convert c termin half continu fold unfold helic structur non canon structur most turn n termin half c termin half flexibl contrast two coronavirus deriv transmembran peptid much stabl fast helix former compar influenza one particular sar deriv peptid e appear fastest stabl helix former four viral peptid studi helic structur persist almost without disrupt whole simul compar result experiment observ benchmark tfe studi conform membran hydrophob peptid work provid accur result suggest methodolog run long md simul predict structur properti biolog import membran peptid | D000086382;D007251 | T047;T067 |
36,239,691 | toxin induc kidney fibrosi via mtros nlrp wnt catenin axi toxin caus kidney fibrosi wnt catenin signal promot kidney fibrosi sustain activ howev whether induc kidney fibrosi involv wnt catenin signal activ explor yet toxin caus renal mitochondri damag lead mitochondri reactiv oxygen speci mtros overproduct nlrp inflammasom activ activ nlrp inflammasom mediat fibrosi howev whether nlrp inflammasom mediat mtros regul induc kidney fibrosi wnt catenin signal unclear studi first confirm toxin caus wnt catenin signal activ mice kidney hk cell second confirm mtros activ nlrp inflammasom expos mice kidney hk cell third confirm nlrp inflammasom regul wnt catenin signal toxin expos mice kidney hk cell final confirm wnt catenin signal regul fibrosi toxin expos mice kidney hk cell result confirm toxin induc kidney fibrosi via mtros nlrp wnt catenin axi | D007674;D013605 | T047;T109;T131 |
36,239,690 | near infrar dual emiss au sr nanoclust tailor intersystem cross work present synthesi intrigu photoluminesc au pet pet phenylethanethiol nanoclust nc au pet nc exhibit dual emiss nm reveal fluoresc phosphoresc respect emiss quantum yield qy au pet dichloromethan room temperatur air quit rare thiolat protect au ncs au pet ncs embed polystyren film solid state fluoresc dramat suppress phosphoresc signific enhanc diverg behavior explain dipolar interact induc enhanc intersystem cross singlet triplet excit state | D011137;D008752 | T121;T109;T131;T122 |
36,239,683 | wnt signal tumor microenviron promot immunosuppress murin pancreat cancer pancreat ductal adenocarcinoma pda associ activ wnt signal whether signal pathway regul tumor microenviron remain unexplor singl cell rna sequenc human pancreat cancer discov tumor infiltr cd cell express tcf encod transcript factor tcf condit inactiv tcf cd express cell mous model pancreat cancer observ chang tumor immun microenviron includ cd cell fewer regulatori cell also compensatori upregul pd l use clinic avail inhibitor porcupin key compon wnt signal observ similar reprogram immun respons wnt signal inhibit limit therapeut window due toxic pd l blockad ineffect pda show combin target reduc pancreat cancer growth experiment model might benefit treatment pancreat cancer | D021441;D010190 | T191 |
36,239,681 | wide field swept sourc optic coher tomographi optic disc pit maculopathi demonstr connect vitreous subretin fluid sourc subretin intraretin fluid patient optic disc pit maculopathi odp remain unclear often thought either vitreous cerebrospin fluid present case year old man develop odp imag wide field swept sourc optic coher tomographi demonstr macular fluid track nasal optic disc pit superonas communic vitreous suggest swept sourc optic coher tomographi use tool determin origin macular fluid patient odp ophthalm surg laser imag retina | D005124;D008268;D009898;D012164 | T047;T019;T023;T033 |
36,239,680 | intravitr methotrex prevent treatment prolif vitreoretinopathi rhegmatogen retin detach systemat review systemat review evalu role methotrex mtx adjunct intravitr agent prevent treatment prolif vitreoretinopathi pvr rhegmatogen retin detach articl investig use mtx patient pvr high risk pvr identifi via search ovid med line embas cochran librari eight studi eye includ patient receiv averag mtx inject dose rang g month follow three control trial retin attach rate logmar improv visual acuiti patient receiv mtx n compar reattach rate logmar improv control n three mild complic relat mtx report research requir given low number studi qualiti evid heterogen case select treatment regimen high risk bias lack random ophthalm surg laser imag retina | D012163;D018630 | T047 |
36,239,679 | long term retin vascular chang age relat macular degener measur use optic coher tomographi angiographi determin age relat macular degener amd status affect longitudin retin vessel chang | D057092;D008268 | T047 |
36,239,678 | prevent iatrogen retin break cutter associ traction chronic vitreous hemorrhag catch describ recogn complic surgic manag dens nonclear vitreous hemorrhag specif develop iatrogen retin break result cutter associ traction | D012163;D012167 | T047 |
36,239,677 | case rhegmatogen retin detach unpredict macular tear treat autolog retin graft year old male present decreas vision follow trauma stone view posterior segment preclud due cortex materi ocular ultrasonographi detect total retin detach g par plana vitrectomi larg macular tear observ find expect autolog retin graft possibl surgic option close macular tear retin graft taken peripheri spread macula postop period retin graft place integr tear autolog retin graft may effect surgic option presenc macular tear ophthalm surg laser imag retina | D008266;D012163;D012167 | T023;T047 |
36,239,676 | macular atrophi incid progress visual acuiti effect year treatment neovascular age relat macular degener macular atrophi contribut declin vision prolong anti vascular endotheli growth factor vegf treatment neovascular age relat macular degener namd greater understand incid evolut impact visual acuiti merit | D008268;D057135 | T047 |
36,239,675 | safeti biolog activ ott novel topic select integrin inhibitor treatment diabet eye diseas phase b studi evalu safeti toler biolog activ topic select integrin inhibitor ott eyedrop administ bid diabet retinopathi dr diabet macular edema dme | D003930;D016023;D008269;D009883 | T047;T116;T192;T122;T129 |
36,239,674 | vitrectomi assist excis treatment juxtapapillari retin capillari hemangioma juxtapapillari retin capillari hemangioma sight threaten hamartoma locat adjac optic nerv nonsurg approach includ laser photocoagul cryotherapi shown effect reduc exud peripher hemangioma howev juxtapapillari hemangioma function outcom limit due associ potenti damag retin nerv fiber layer present year old femal patient von hippel lindau vhl diseas present juxtapapillari retin capillari hemangioma associ traction epiretin membran erm secondari macular hole vitrectomi assist excis lesion inner limit membran ilm peel around macular hole visual acuiti macular anatomi recov month follow ophthalm surg laser imag retina | D019773;D018325;D018324;D019572;D012167;D006623 | T191;T047;T020 |
36,239,672 | rhegmatogen retin detach variat clinic present surgic outcom socioeconom status race character rhegmatogen retin detach rrd present repair outcom race socioeconom status | D005901;D012163 | T047 |
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