PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
|---|---|---|---|
36,239,646 | congenit hypermetabol uncoupl oxid phosphoryl describ case ident twin boy present low bodi weight despit excess calor intak evalu fibroblast show elev oxygen consumpt decreas mitochondri membran potenti exom analysi reveal de novo heterozyg variant atpfb encod subunit mitochondri atp synthas also call complex v yeast mutat affect region loosen coupl proton motiv forc atp synthesi result high rate mitochondri respir express mutant allel human cell line recapitul phenotyp data support autosom domin mitochondri uncoupl syndrom hypermetabol fund nation institut health | D028361;D025261;D010085;D010101 | T047;T116;T126;T201;T044 |
36,239,645 | trial thrombectomi hour stroke due basilar arteri occlus effect risk endovascular thrombectomi hour stroke onset due basilar arteri occlus extens studi | D001157;D001488;D057510;D020521;D017131 | T061;T047;T023 |
36,239,644 | trial endovascular treatment acut basilar arteri occlus data trial investig effect risk endovascular thrombectomi treatment stroke due basilar arteri occlus limit | D001157;D001488;D057510;D020521;D017131 | T061;T047;T023 |
36,239,632 | garp complex prevent sterol accumul tran golgi network dendrit remodel membran traffick essenti sculpt neuron morpholog garp earp complex conserv tether regul vesicl traffick secretori endolysosom pathway respect complex contain vps vps vps protein complex specif protein vps garp vps earp drosophila find complex requir dendrit morphogenesi development remodel multidendrit class iv da cda neuron found sterol accumul tran golgi network tgn vpskoko neuron investig gene regul sterol relat lipid tgn overexpress oxysterol bind protein osbp knockdown pik four wheel drive fwd exacerb vpskoko phenotyp wherea elimin one allel osbp rescu suggest excess sterol accumul tgn part respons inhibit dendrit regrowth find distinguish garp earp complex neurodevelop implic vesicl traffick lipid transfer pathway dendrit morphogenesi | D003712;D046912;D033921;D021601 | T026;T126;T116;T123 |
36,239,631 | converg secretori endosom autophag rout tran golgi associ lysosom tran golgi complex traffic connect exist endolysosom system addit main golgi plasma membran secretori rout investig three hit drosophila screen display secretori cargo accumul autophag vesicl escrt iii compon vps snare bind rop lysosom pump subunit vhappa found vps rop lysosom marker local near tran golgi furthermor document vicin tran golgi main cellular locat lysosom earli late recycl endosom associ well tran golgi associ degrad compart basal microautophagi secretori cargo materi occur disrupt compart caus cargo accumul hit includ munc homolog rop requir syx syx rab mediat endosom recycl final besid basal microautophagi show tran golgi associ degrad compart contribut growth autophag vesicl development starvat induc macroautophagi result argu fli tran golgi gravit center whole endomembran system | D001343;D011992;D006056;D008247 | T043;T026 |
36,239,617 | techniqu earli outcom high energi calcaneus fractur treat stage extern fixat combin open reduct intern fixat subtalar arthrodesi present effect surgic techniqu treatment open high energi calcan fractur signific soft tissu injuri present complic techniqu evalu patient report outcom stage extern fixat follow delay reconstruct open reduct intern fixat orif subtalar arthrodesi | D016512;D002111;D050723;D007718 | T023;T037 |
36,239,606 | mechan robust flame retard superhydrophob textil anti biofoul perform attach bio fluid surfac promot transmiss diseas superhydrophob textil may offer signific advantag reduc adhes bio fluid howev yet found widespread use dri remnant adher strong poor mechan chemic robust addit massiv use polym textil featur fire heat resist reduc injuri loss suffer peopl fire accid develop superhydrophob textil cover hybrid coat titanium dioxid polydimethylsiloxan tio pdms textil exhibit low adhes bio fluid also dri blood compar hydrophil textil peel forc coat textil dri blood time lower textil superhydrophob surviv sever treatment sandpap mesh high pressur kpa even microstructur break furthermor textil show excel heat resist c flame retard properti compar untreat textil benefit great inhibit flame spread reduc sever burn caus polym textil adher skin melt high temperatur | D005411 | T120 |
36,239,601 | trace transform alloc newli appli p calcar soil use enrich oxygen isotop label techniqu differ phosphorus p fertil signific impact transform appli p soil howev knowledg differ p fertil regim influenc alloc amend p soil remain incomplet herein carri pot experi explor fate appli p calcar soil use oxygen isotop label techniqu p treatment includ check ck singl repeat applic phosphorus mass balanc result show appli p held labil moder labil fraction repeat treatment approxim ad p recov nonlabil form singl applic treatment isotop tracer p result demonstr p valu nahco p naoh p repeat p applic signific higher singl p applic ultim better agronom perform crop higher pue achiev repeat treatment find highlight repeat p fertil improv p avail reduc p fixat result pronounc enrich oxygen isotop techniqu consid effect approach trace appli p soil | D012987;D010100 | T121;T167;T123;T196 |
36,239,595 | trichoderma atrovirid hyphal regener conidi depend cell signal process regul microrna like rna abil respond injuri essenti surviv organ involv analog mechan anim plant mechan integr coordin genet metabol reprogram event requir regul small rnas adequ heal wound area previous report respons injuri filament fungus trichoderma atrovirid involv molecular mechan close resembl plant anim lead format new hypha regener develop asexu reproduct structur conidiophor howev involv microrna process investig fungi work explor particip microrna like rnas milrna molecul sequenc messeng small rnas injuri respons wt strain rnai mutant found dcr appear play import role hyphal regener requir produc major srnas atrovirid also determin three main milrna produc via dcr induc damag trigger development process import elimin singl milrna phenocopi main defect observ dcr mutant result demonstr essenti role milrna hyphal regener asexu develop post transcript regul cellular signal process involv phosphoryl event observ allow us conclud fungi like plant anim respons damag activ fine tune regulatori mechan | D006999;D035683 | T123;T004;T114 |
36,239,585 | perform direct axillari arteri cannul choic arteri cannul site matter debat year femor arteri use long time due eas isol possibl percutan cannul howev associ risk embol retrograd flow danger case aortic dissect perfus unpredict retrograd flow expos patient risk malperfus cannul axillari arteri recent gain popular advantag particular antegrad aortic perfus cardiopulmonari bypass abil facilit cerebr perfus hypotherm circulatori arrest show tip trick facilit isol direct cannul axillari arteri think procedur practic cardiac surgeon even begin practic | D000784;D001366 | T047;T046;T023 |
36,239,583 | n termin lysozym conjug cation polym enhanc antimicrobi activ overcom antimicrobi resist microbi resist antibiot one greatest global healthcar challeng urgent need develop effect strategi overcom antimicrobi resist herein report photoinduc situ growth cation polym n terminus lysozym attach cation polym improv proteolyt thermal stabil lysozym notabl conjug effici overcom lysozym resist gram posit bacteria antibiot resist gram negat bacteria may ascrib synergist interact lysozym cation polym bacteria disrupt cell membran rat periodont model lysozym polym conjug great outperform lysozym therapeut efficaci also superior minocyclin hydrochlorid gold standard periodont therapi find may provid effici strategi dramat enhanc antimicrobi activ lysozym pave way overcom antimicrobi resist | D009113;D000900 | T121;T126;T116;T195 |
36,239,557 | heterochir dipeptid phenylalanyl l phenylalanin h phe l phe oh potenti induc metastat suppressor nmh p wild type mutant cell recent year signific progress made use case small peptid diversifi edific henc versatil applic scope cancer therapi identifi heterochir dipeptid h phe l phe oh f potent induc metastat suppressor nmh divulg effect f major emtmetastasi associ gene implic invas migrat abil cancer cell anti invas potenti f direct correl nmh express mechanist f treatment elev p level valid local transcript studi nmh knockdown condit f fail induc p expressionnuclear local indic upregul p express f nmh depend also demonstr antimetastat potenti f primarili mediat nmh irrespect p status cell howev nmh function p protein conjunct govern apoptot cytostat potenti f coimmunoprecipit studi unravel augment p nmh interact p wild type cell howev p mutat cell enrich evidenc employ mous isogen cell line p determin vivo efficaci f spontan experiment model decreas tumor volum cohort inject p cell demonstr antimetastat potenti f reliant nmh p activ requir ablat primari tumor burden find unravel f treatment induc signific abrog migrat invas metastat potenti p wild type p defici cancer mediat nmh | D016159;D009369 | T191;T123;T116 |
36,239,547 | tumor deriv extracellular vesicl confer fluorouracil resist esophag cancer via long noncod rna ac deliveri fluorouracil fu resist one main caus treatment failur esophag cancer ec intend elucid mechan tumor deriv extracellular vesicl tev encapsul long noncod rnas lncrnas ac fu resist ec ev isol serum sampl ec patient heec te te fu cell follow rt qpcr detect ac express ev relationship among ac microrna mir semaa evalu next ec cell cocultur ev follow lentivirus transduct plasmid transfect studi role tev ac ec cell relat mir semaa tumor format nude mice appli vivo confirm elev ac express seen ev serum fu insensit patient fu resist ec cell mechanist ac bound mir invers target semaa ec cell ev oe ac augment ec cell viabil coloni format fu resist diminish apoptosi mir mediat semaa furthermor ev oe ac augment tumor format fu resist ec cell vivo conclus data offer evid promot mechan tev fu resist ec deliv ac | D062085;D035683;D004938;D000067128 | T191;T026;T123;T114 |
36,239,529 | evalu relationship reduc fetal movement obstetr neonat outcom placent patholog fetal movement one simpl method show babi well condit associ decreas fetal movement determin import analyz differ aspect studi aim evalu relationship reduc fetal movement obstetr neonat outcom placent patholog | D005317;D010920 | T018;T046 |
36,239,476 | spintip simpl robust versatil preanalyt method microscal suspens cell proteom sampl loss contamin critic preanalyt pitfal microscal proteom applic nonadh cell common assay workflow easili adopt microscal sampl size suspens cell due inadvert sampl loss imped preanalyt experiment manipul limit suspens cell sampl microscal proteom applic encount primari human materi describ test simpl manual batch techniqu singl step fold concentr scarc number dilut suspens cell cell volum reduct facilit microscal experi suspens cell pipett tip heat seal orific spintip manufactur within min serv versatil microcentrifug vessel supernat aspir minim cell loss residu volum approxim l achiev without visual cell pellet result show spintip enabl concentr medium exchang wash cultur high limit amount suspens cell function manipul microscal proteom readili incorpor standard workflow applic illustr profil ex vivo respons primari acut myeloid leukemia aml cell one aml patient daunorubicin dnr depth quantifi protein excel repeat | D040901;D015470 | T191;T091 |
36,239,464 | mitochondria target luminesc organotin iv complex synthesi photophys character live cell imag five fluoresc ono donor base organotin iv complex sn iv l ph synthes one pot reaction method fulli character spectroscop includ singl crystal x ray diffract studi detail photophys character compound perform compound exhibit high luminesc properti quantum yield addit result cellular permeabl analysi suggest lipophil easili absorb cell confoc microscopi use examin live cell imag capabl result show compound most intern mitochondria exhibit neglig cytotox imag concentr also exhibit high photost compar commerci dye use long term real time track cell organell also found probe high toler chang mitochondri morpholog thus kind low toxic organotin base fluoresc probe assist imag mitochondria within live cell track chang morpholog | D005456;D009947 | T109;T130 |
36,239,452 | acycl heterocycl azadien diel alder reaction promot perfluoroalcohol solvent hydrogen bond comprehens examin scope herein first use perfluoroalcohol h bond acceler acycl azadien invers electron demand cycloaddit reaction describ use promot heterocycl azadien cycloaddit reaction general examin complet rang azadien scope dienophil comprehens explor relat reactiv trend solvent compat establish respect dienophil well azadien h bond solvent effect lead rate enhanc yield improv impact regioselect mode cycloaddit defin new viabl dienedienophil reaction partner cycloaddit reaction disclos key comparison rate constant report perfluoroalcohol effect acceler invers electron demand diel alder cycloaddit direct correl h bond potenti p k reaction electron rich dienophil acceler strain even unactiv alken alkyn improv includ repres bioorthogon click reaction | D000475;D000480 | T109 |
36,239,443 | quantifi sphingomyelin dairi infus base shotgun mass spectrometri lithium ion induc fragment quantifi sphingomyelin sm speci infus base mass spectrometri ms complic presenc isobar phosphatidylcholin pc speci generat common z product ion presenc ammonium ion result phosphocholin headgroup lithium ion adduct sm undergo select dehydr li h ch nc h po correspond neutral loss da neutral loss employ creat sm select method identifi target speci quantit use multipl reaction monitor mrm sm select fragment ms use character sphingosin base acyl chain method use identifi individu sm speci bovin milk rang sm sm base acyl fatti acid rang carbon desatur spike sm standard milk recoveri endogen milk sm coeffici variat intra interday variabl limit detect nm limit quantit nm ms mrm method employ accur precis quantifi sm speci dairi product includ bovin deriv whole milk half half whip cream goat milk | D013109;D064751 | T104;T109;T123;T197 |
36,239,441 | direct evolut laccas improv thermal stabil facilit droplet base microfluid screen system laccas attract biocatalyst industri due broad substrat spectrum use oxygen final electron acceptor water sole byproduct increas effort devot engin laccas improv properti droplet base microfluid screen dmfs technolog acceler screen procedur probe larg sequenc space studi dmfs system includ heat step picoinject use sort larg laccas librari yield variant enhanc thermotoler obtain amino acid substitut distribut surfac laccas interest recombin three identifi substitut asp asn surfac result best variant exhibit fold higher remain activ c fold higher remain activ incub organ solvent solut vv methanol ethanol ionic liquid solut vv ethyl methylimidazolium ethyl sulfat h furthermor molecular dynam simul reveal recombin three benefici substitut aspasn aspasn aspasn surfac introduc hydrogen bond compar wild type made thermost studi highlight import dmfs system effici identif benefici long distanc amino acid substitut | D042845;D052578 | T103;T120;T126;T116 |
36,239,438 | vivo mous model chronic inflamm induc immun suppress factori myeloid deriv suppressor cell mdscs myeloid deriv suppressor cell mdscs repres heterogen popul immatur myeloid cell known play role perpetu wide rang patholog chronic infect autoimmun diseas cancer mdscs first identifi mice marker cdb gr later base morpholog classifi two subset polymorphonuclear mdscs identifi marker cdb lyg lyc low monocyt mdscs detect cdb lyg lyc hi mdscs studi immunosuppress cell various diseas character chronic inflamm associ diseas causestrigg pathogen autoantigen cancer therefor differ diseas may divers affect mdsc metabol migrat differenti thus influenc generat mdsc function featur ensu suppress environ order studi mdscs patholog free environ establish calibr high reproduc mous model result develop chronic inflamm major caus mdsc accumul immun suppress model present use studi mdsc phenotyp function divers plastic also permit studi mdsc migrat bone marrow peripher lymphat non lymphat organ mdsc crosstalk extrins factor vivo ex vivo furthermor model serv platform assess effect anti mdsc modal author current protocol publish wiley period llc basic protocol repetit mtb immun induct chronic inflamm altern protocol creat lower grade inflamm chang site immun altern protocol vivo evalu immun status support protocol prepar reconstitut mtb aliquot mtb ifa emuls three inject support protocol prepar ovalbumin lentivir express vector support protocol fluoresc titer assay lentivir express vector support protocol spleen excis tissu dissoci prepar singl cell suspens support protocol label splenocyt cfse prolifer dye | D000072737;D009369 | T191;T025 |
36,239,433 | explor maldi biotyp identif corynebacterium pseudotuberculosi biovar ovi equi biochem serolog molecular method develop laboratori diagnosi diseas caus c pseudotuberculosi cp identif pathogen biovar differenti may time consum expens confus compar bacteria studi aim evalu maldi biotyp overal genom related index ogri analysi optim identif differenti biovar c pseudotuberculosi strain isol sever host countri precis classifi use maldi biotyp bionumer platform classif accuraci ovi equi biovar respect analyz sampl strain averag nucleotid ident base blast tetra analys use genom sequenc data possibl differenti strain equi ovi data show maldi biotyp ogri analysi help identifi c pseudotuberculosi speci biovar level | D016925 | T007 |
36,239,428 | novel effici multistag lead optim pipelin experiment valid dyrkb select inhibitor addit general challeng drug discoveri identif lead compound time cost effect way specif challeng also exist particular necessari develop pharmacolog inhibitor effect discrimin close relat molecular target dyrkb kinas consid valuabl target cancer specif mono combin chemotherapi howev inhibit close relat dyrka kinas benefici exist inhibitor target kinas essenti effici unavail dyrkb crystal structur make discoveri dyrkb specif inhibitor even challeng propos novel multi stage compound discoveri pipelin aim silico identif potent select small molecul larg set initi candid method use structur base dock ligand base quantit structur activ relationship model approach allow us identifi lead runner small molecul compound target dyrkb high effici specif | D011505;D047428 | T121;T126;T116 |
36,239,412 | loss function matern membran oestrogen receptor er alter expans trophoblast cell impact mous fertil bind oestradiol oestrogen receptor alpha er play crucial role control reproduct act nuclear membran initi signal studi physiolog role membran er reproduct system use ca er mous model select loss function membran er despit ca er mice describ steril daili weigh ultrasound imag reveal homozyg femal becom pregnant allow investig role er pregnanc first time neonat death mutant offspr mice result delay parturit associ failur pre term progesteron withdraw moreov pregnant ca er femal exhibit partial intrauterin embryo arrest e observ embryon lethal result alter expans tpbpa posit spiral arteri associ trophoblast giant cell utero placent unit associ imbal express angiogen factor togeth process control trophoblast mediat spiral arteri remodel henc loss membran er within matern tissu clear alter activ invas trophoblast cell placentogenesi previous unreport function membran er could open new avenu toward better understand human pregnanc associ patholog | D047628;D014327 | T018;T116;T192 |
36,239,406 | explor cardiac effect oxytocin iu carbetocin g randomis control trial women undergo plan caesarean deliveri oxytocin stimul releas myocardi biomark troponin prolong qtc induc st depress | D010120;D006473 | T121;T046;T039 |
36,239,403 | presenc partner oper room emerg caesarean section scope review emerg caesarean section often urgent limit time inform guid parent prefer leav partner outsid oper room let partner accompani mother | D000773;D000765 | T061 |
36,239,397 | metal niobium nitrid open nanocav surfac enhanc raman spectroscopi construct open hot spot structur facilit entri analyt crucial surfac enhanc raman spectroscopi metal niobium nitrid nbn three dimension hierarch network open nanocav structur first found exhibit strong visibl light local surfac plasmon reson lspr effect extraordinari surfac enhanc raman scatter ser perform uniqu nanocav structur allow easi entri molecul promot util electromagnet hot spot nbn substrat lowest detect limit raman enhanc factor ef contamin furthermor nbn hierarch network possess outstand environment durabl high signal reproduc detect univers remark ser sensit nbn substrat attribut joint effect lspr interfaci charg transport ct | D013059;D009556 | T059;T196;T070 |
36,239,383 | electrochem aptasens sar cov base triangular prism dna nanostructur dumbbel hybrid chain reaction develop conveni accur sensit method rapid screen sever acut respiratori syndrom coronavirus sar cov infect high desir studi develop facil electrochem aptasensor detect sar cov protein amplifi dumbbel hybrid chain reaction dhcr triangular prism dna tpdna nanostructur first assembl modifi electrod interfac due multipl thiol anchor immobil quit stabl tpdna nanostructur also provid excel scaffold better molecular recognit effici top singl strand region dhp aptam sequenc toward sar cov protein previous local partial hybrid dhp presenc target protein aptam sequenc displac dhp expos introduct fuel stand dhcr compress dna linear assembl occur product stack tpdna nanostructur enrich electrochem speci electrochem method success detect target protein clinic sampl provid simpl robust accur platform great potenti util | D052157;D000086382;D049329;D015374 | T047;T073;T059;T075;T114;T067 |
36,239,382 | biomechan effect age relat structur chang cervic intervertebr disc finit element studi previous literatur investig biomechan respons healthi degen disc biomechan respons suboptim healthi intervertebr disc receiv less attent purpos compar biomechan respons risk herniat young healthi suboptim healthi degen intervertebr disc cervic spine model establish valid use finit element method suboptim healthi mild moder sever degen disc model develop disc height deform rang motion intradisc pressur von mise stress annulus fibrosus analyz appli moment nm flexion extens later bend axial rotat n compress load disc height deform young healthi suboptim healthi mild moder sever degen disc respect decreas order rang motion young healthi spine suboptim healthi spine mild degen spine moder degen spine sever degen spine mean stress annulus ground substanc suboptim healthi disc higher young healthi disc mean stress inter lamellar matrix annulus ground substanc moder sever degen disc higher disc age relat structur chang degen chang increas stiff reduc elast deform intervertebr disc decreas rang motion due effect age degener intervertebr disc may caus compens adjac segment lead progress degener multipl segment effect age intervertebr disc increas risk annulus fibrosus damag biomechan point view moder sever degen disc may higher risk herniat due higher risk damag layer separ annulus fibrosus caus increas stress annulus ground substanc inter lamellar matrix | D007403;D055959 | T023;T190;T047 |
36,239,381 | develop multibodi knee model unload knee cartilag penetr depth control unload knee brace could reliev pain decreas medial knee load particular knee osteoarthr koa patient studi investig relev knee model identifi influenti paramet sinc koa caus cartilag joint lose elast thick lack normal bone bone separ pain believ cartilag penetr depth control impact strategi research moreov knee contact forc koa fewer healthi knee confirm contact forc control straight factor therefor biomechan human knee model develop generic procedur dynam analysi contact problem combin musculoskelet model introduc develop model includ geometr express collis curv algorithm determin collis point present address cartilag penetr depth contact forc calcul nonlinear discontinu contact law view femur tibia relat motion analyz combin collis reaction cartilag bone knee simul maximum penetr depth healthi knee report mm koa mm includ mm cartilag cartilag contact mm bone bone contact top unload n achiev reduc penetr depth mm avoid bone bone contact propos procedur low comput give us suitabl analysi method design knee assist devic | D002358;D020370 | T047;T024 |
36,239,373 | dynam proteom phosphoproteom atlas corticostriat axon neurodevelop mammalian axon develop begin embryon stage continu postnat birth axon proteom landscap chang rapid coordin transcript protein turnov post translat modif comprehens profil axon proteom across neurodevelop limit studi lack cell type neural circuit specif result substanti inform loss creat cre depend apex report mous line map cell type specif proteom corticostriat project across postnat develop synthes analysi framework defin tempor pattern axon proteom phosphoproteom identifi co regul protein phosphoryl associ genet risk human brain disord discov prolin direct kinas major development regul apex transgen report proxim label offer flexibl strategi subcellular proteom cell type specif earli neurodevelop critic period neuropsychiatr diseas | D040901;D020543 | T091;T123;T116 |
36,239,372 | anophel home suppress drive candid exhibit unexpect perform differ simul spatial structur recent experi produc sever anophel gambia home gene drive disrupt femal fertil gene therebi eventu induc popul collaps drive may high effect tool combat malaria one home drive base zpg promot drive crisprca abl elimin cage popul mosquito second version purport improv upon first incorpor x shredder element bias inherit toward male offspr similar success analyz experiment data gene drive extract characterist perform paramet compar previous interpret experiment perform assess suppress drive within individu base simul framework model mosquito popul dynam continu space find combin homingx shredder drive actual less effect popul suppress within context mosquito popul model particular combin drive often fail complet suppress popul instead result unstabl equilibrium drive wild type allel contrast otherwis similar drive base nos promot may prove promis candid futur develop origin thought | D000852;D008288 | T047;T204 |
36,239,370 | covid czech republ compar analysi probabl work relat transmiss coronavirus sar cov aim analysi determin probabl place coronavirus transmiss associ work compar situat | D000086382;D009784 | T047;T067 |
36,239,369 | healthcar associ infect covid icu patient two centr studi aim retrospect studi estim preval healthcar associ infect hai microbiolog data includ resist pattern impact hai patient surviv | D000890;D000086382;D003428;D014552 | T121;T047;T067 |
36,239,368 | preval influenc factor myopia high myopia schoolchildren shandong china aim studi identifi preval risk factor myopia high myopia student primari school junior high school shandong | D009216;D012029 | T047;T201 |
36,239,367 | influenc school backpack load plantar foot pressur walk year old girl studi aim assess relat load midfoot metatars feet schoolchildren walk backpack differ load | D012574;D016138 | T056;T169;T092;T073 |
36,239,366 | relev dietari exposur acrylamid form heat process agri food product acrylamid aa consid one contamin occur heat process agri food product diet increas risk develop cancer consum age group | D020106;D000074341 | T109;T131;T037 |
36,239,365 | clinic predictor metal allerg sensit orthodont patient studi aim assess predictor allerg sensitis titanium nickel patient undergo orthodont treatment | D002613;D003877;D006967 | T047;T046 |
36,239,364 | impact post chernobyl radiat flow cytometri paramet human sperm aim studi analys long term radiat effect human sperm | D047852 | T068 |
36,239,363 | econometr analysi oncolog patient health relat qualiti life determin bulgaria present studi investig determin oncolog patient health relat qualiti life hrqol bulgaria look patient characterist includ control variabl estim model demograph time diseas onset studi relev hrqol divers factor relat physic psycholog dimens patient ill experi level pain anxietydepress concern specif patient therapeut path ie feel particip therapi perceiv uncertainti ill predict complex qualiti inform receiv nurs medic personnel | D009369;D011788 | T191;T078 |
36,239,362 | pregnant women belief third hand smoke exposur tobacco smoke aim studi reveal pregnant women belief third hand smoke exposur tobacco smoke | D011248;D062789;D014028 | T046;T073;T131;T069;T109;T033 |
36,239,361 | use psychedel czech republ result recent popul survey differ psychoact substanc wide use today societi far limit data avail use psychedel general popul main aim studi estim number user substanc psychedel properti classic psychedel cannabi ecstasi ketamin czech republ | D002188;D006213;D013287;D007649;D019966 | T002;T167;T131;T121;T109;T048;T033 |
36,239,360 | alzheim diseas type diabet review review articl deal question whether type diabet risk factor develop alzheim diseas | D000544;D060825;D003920 | T047;T048 |
36,239,358 | roast pretreat walnut juglan regia l kernel improv oil flavor profil correl chemic composit present studi focus role roast pretreat improv flavor wos total volatil compound detect odor perceiv aroma activ compound identifi wos use headspac solid phase microextract gas chromatographi mass spectrometri hs spme gc ms aroma extract dilut analysi gas chromatographi olfactometri aedagc result indic extend roast pretreat effect generat aldehyd pyrazin aroma activ compound wos correl aroma activ compound chemic composit identifi pearson correl analysi branch chain aldehyd methylbutan maillard reaction product ribos precursor pyrazin aroma activ compound also relat ribos absolut correl coeffici among pyrazin compound ethyl methylpyrazin show strong correl isoleucin arginin methylpyrazin trimethylpyrazin show strong correl glycin lysin histidin determin effect roast aroma activ compound alter studi aroma precursor help walnut oil flavor qualiti control direct enabl industri applic | D031324;D055549 | T109;T002 |
36,239,357 | news around rna world new avenu rna biolog biotechnolog therapeut sibbm meet sinc formal central dogma molecular biolog relev rna modul flow inform dna protein clear recent discoveri vast set non code transcript involv crucial aspect cellular biolog renew enthusiasm rna communiti moreov remark impact rna therapi face covid pandem bolster interest translat opportun provid incred molecul reason italian societi biophys molecular biolog sibbm decid dedic th year meet held june rome mani fascin aspect rna biolog thirti nation intern speaker cover properti mode action applic rna role control develop cell differenti involv diseas summar scientif content confer highlight take home messag present stress direct communiti current explor push forward comprehens rna world | D000086382;D012313 | T047;T067;T114 |
36,239,346 | oxid trifluoroacetoxyl benzyl c sp h bond donor use n trifluoroacetoxyquinuclidinium salt photoredox catalysi n trifluoroacetoxyquinuclidinium trifluoroacet prepar situ quinuclidin n oxid cfco except electron poor substrat reagent allow high yield oxid trifluoroacetoxyl benzyl c h bond photocatalyt condit trifluoroacetoxyl ibuprofen methyl ester allow select function benzyl c h bond alkylbenzen hydrogen atom transfer benzyl c h bond quinuclidin cation radic propos reaction product determin step | D012492;D011812 | T104;T109 |
36,239,326 | carbon quantif soil differ textur use laser induc breakdown spectroscopi spectral interfer correct use plane model soil carbon c determin wide studi due soil c sequestr contribut mitig greenhous gas emiss improv soil qualiti howev tradit chemic process larg scale analysi generat wast time consum high cost per measur laser induc breakdown spectroscopi lib multi element spectroanalyt techniqu allow fast low cost analysi almost sampl prepar requir generat hazard chemic wast two emiss line common use lib c determin nm howev brazilian soil high concentr aluminum al iron fe direct interf c emiss line furthermor multipl soil textur increas difficulti build calibr model due matrix effect present work mathemat model propos quantifi total c soil sampl differ textur bypass spectral interfer lib specif method remov outlier develop spectrum remov univari analysi notic result project surfac space plane model obtain good fit evalu c emiss line r limit detect limit quantit line nm respect three repetit use test robust method present r mean error line nm respect root mean squar error predict lower line | D012987;D002244 | T121;T167;T196 |
36,239,312 | cxcl defin lung endotheli heterogen promot distal vascular growth grow amount data uncov cellular divers pulmonari circul mechan govern vascular repair injuri howev molecular cellular mechan contribut morphogenesi growth pulmonari vasculatur embryon develop less clear import deficit vascular develop lead signific pediatr lung diseas indic need uncov fetal program promot vascular growth address use transgen mous report express cxcl arteri endotheli hallmark gene perform singl cell rna sequenc isol cxcl dsred endothelium assess cellular heterogen within pulmonari endothelium combin cell annot gene ontolog histolog analysi allow us segreg develop arteri endothelium function spatial distinct subpopul express cxcl highest distal arteri endotheli subpopul compart enrich gene vascular develop accord disrupt cxcl signal led abnorm branch also distal vascular hypoplasia data provid evid arteri endotheli function heterogen reveal conserv signal mechan essenti pulmonari vascular develop | D008168;D004730 | T023;T024 |
36,239,303 | improv physicochem vitro hypolipidem properti solubl dietari fiber camellia seed residu cellulos degrad fungus yc camellia seed residu csr main product edibl oil extract camellia seed potenti low cost sourc solubl dietari fiber sdf howev lower yield function properti limit applic csr sdf food industri fulli util resourc studi cellulos degrad fungus yc screen use modifi sdf csr ferment yc physicochem structur vitro hypolipidem properti csr sdf improv scan electron microscopi x ray diffract molecular weight distribut flow properti show ferment endow f sdf ferment porous microstructur lower crystallin smaller molecular weight higher viscos result monosaccharid composit fourier transform infrar spectroscopi point differ monosaccharid percentag function group type ck sdf control f sdf alter combin achiev improv hydrat properti hypolipidem activ csr sdf includ water hold capac oil retent capac cholesterol adsorpt capac pancreat lipas inhibit capac bile acid bind capac overal result indic yc could use ideal strain ferment modif sdf csr f sdf potenti serv hypolipidem compon function food | D002482;D028244 | T002;T109;T123;T122 |
36,239,298 | long last viscer hypersensit model dss induc coliti rat persist viscer hypersensit key compon function inflammatori gastrointestin diseas current anim model fail fulli reproduc characterist viscer pain human particular relat persist hypersensit work explor valid dss induc coliti rat model mimic chronic intestin hypersensit | D003092;D059265 | T047;T184 |
36,239,291 | even primros seed extract rich polyphenol modul invas colon cancer cell regul tym express natur polyphenol plant metabolit exhibit broad rang biolog activ among anticanc properti seem desir studi examin anticanc anti metastat properti polyphenol rich extract even primros seed epe vitro vivo studi perform colorect cancer crc cell line aom dss induc coliti associ colon cancer mice reveal epe anticanc properti furthermor studi epe activ metastat abil show epe inhibit invas follow model cell isol patient differ invas stage cell induc invas either snail overexpress caf stimul import also demonstr epe decreas cell invas fluorouracil fu resist crc cell inhibit metastasi correl decreas thymidyl synthetas tym recent associ metastat phenotyp develop result indic epe might effect anticanc agent suppress colon cancer metastasi regardless invas caus base find conclud use epe extract rich polyphenol inhibit cell invas tym downregul | D031665;D003110 | T191;T002 |
36,239,281 | facil chemoenzymat synthesi unmodifi anticoagul ultra low molecular weight heparin chemoenzymat approach mimick biosynthet pathway heparin heparan sulfat hs well develop prepar seri structur well defin heparin oligosaccharid excel anticoagul activ good overal yield current chemoenzymat synthesi typic begin unnatur glycosyl acceptor p nitrophenyl glucuronid glca pnp conveni detect recoveri purif although afford heparin molecul undesir structur characterist herein describ facil chemoenzymat strategi assist specif cleavag heparinas iii high effici synthesi unmodifi heparin heptasaccharid demonstr potent anticoagul activ vitro commensur pharmacokinet profil fondaparinux success generic strategi applic scalabl synthesi divers hsheparin molecul complet natur structur featur promis therapeut agent | D000925;D006495 | T121;T109 |
36,239,278 | genet diagnosi renal biopsi find set renal genet clinic genet test becom avail util earli diagnost tool nephrolog common object studi examin diagnost agreement renal biopsi find genet diagnos retrospect studi conduct februari total patient genet diagnosi histolog result n nephrectomi n biopsi collect clinic renal biopsi find genet inform relationship histolog find genet diagnos classifi concord nonspecif discord total male femal includ mean age year clinic suspicion alport syndrom common reason referr n follow nephrot syndrom n n cystic kidney diseas n isol hematuria n non nephrot proteinuria n overal concord rate renal histolog genet diagnos nonspecif biopsi result observ discord result observ patient refer suspect alport syndrom pathogeniclik pathogen variant one cola gene two case low syndrom one pax associ nephropathi discord histolog find agreement renal histolog find genet result vari base reason referr complet agreement patient refer alport syndrom howev exampl renal biopsi show secondari find specif associ under genet result | D009394 | T047 |
36,239,276 | measur muscl protein synthesi human influenc nutrit state clinic scienc publish paper use infus stabl isotop label amino acid assess skelet muscl protein synthesi fast fed state period increas intak omega fatti acid respect paper high cite overview studi design key find novel featur consider last impact two paper present earlier paper introduc stabl isotop tracer approach human show consum meal increas whole bodi oxid synthesi breakdown protein protein synthesi greater breakdown result net accumul protein paper also demonstr consum meal promot net protein synthesi skelet muscl later paper introduc concept omega polyunsatur fatti acid abl improv anabol report week consumpt high dose omega fatti acid healthi young middl age adult increas skelet muscl protein synthesi hyperaminoacidem hyperinsulinem clamp compar seen clamp studi entri omega fatti acid also increas phosphoryl import signal protein muscl includ mammalian target rapamycin psk akt clamp two paper remain relev offer experiment approach studi human patho physiolog differ context present novel insight impact nutrit state feed specif nutrient omega fatti acid muscl protein synthesi suggest way explor potenti intervent help prevent revers age diseas disus associ declin muscl mass | D015525;D009124 | T121;T109;T123;T116 |
36,239,271 | symmetri base classif forc drive chromatin dynam chromatin function form dna cell exist form polym immers nucleoplasm fluid insid cell nucleus chromatin nucleoplasm subject activ forc result local biolog process activ lead non equilibrium phenomena affect chromatin organ dynam yet under physic far understood expand upon previous develop two fluid model chromatin nucleoplasm consid three type activ form forc dipol two forc dipol act fluid either polym nucleoplasm third two forc push chromatin solvent opposit direct find latter type result signific flow domin length scale interest due friction fluid viscos observ emerg screen length scale activ flow system predict presenc differ activ type relat strength infer observ power spectra hydrodynam fluctuat chromatin nucleoplasm | D002843;D002467 | T026;T116 |
36,239,258 | abnorm express hadh enzym fatti acid oxid affect tumor develop prognosi review tumor occurr progress close associ abnorm energi metabol energi metabol associ glucos protein lipid reprogram energi metabol one hallmark cancer form energi metabol fatti acid metabol includ fatti acid uptak de novo synthesi oxid recent year role abnorm fatti acid oxid tumor gradual recogn mitochondri trifunct protein mtp serv import role fatti acid oxid hadh two subtyp subunit hadha subunit hadhb import subunit mtp hadh particip step fatti acid oxid howev review summar specif role hadh tumor therefor present studi focus hadh main indic explor chang fatti acid oxid sever type tumor present review summar chang hadh organ cerebrum oral caviti esophagus liver pancrea stomach colorectum lymph lung breast kidney effect downregul relationship hadh prognosi summari hadh either suppressor promot depend tumor locat close associ prognost assess hadha hadhb similar prognost role known compar tumor | D063993;D009369 | T191;T123;T116 |
36,239,255 | enhanc identif ginsenosid simultan seven panax herbal extract data depend acquisit includ prefer precursor ion list deriv hous program virtual librari data depend acquisit dda wide util metabolit identif natur product research food scienc howev suffer low coverag potenti solut improv dda coverag includ precursor ion list pil aim construct pil contain dda strategi base hous librari ginsenosid vlg identifi ginsenosid simultan seven panax herbal extract vlg combin mass defect filter could effici screen ginsenosid precursor elabor separ pil involv dda ginseng extract consequ could character ginsenosid includ one unknown mass use panax ginseng extract superior strategi embodi target known ginsenosid mass newli acquir ms spectra compon conclus knowledg base larg scale molecular predict pil dda repres power targeteduntarget strategi benefici novel natur compound discoveri | D005894;D036145;D001688 | T121;T109;T123;T002 |
36,239,249 | pain reduct valid rat pain model radio frequenc spectrum target low ultra low end use emul deliveri system emul therapeut inc emtx develop technolog deliv time vari magnet field wav file emit extrem low low spectrum radio frequenc dc khz appli regul pain sensat low power field milli gauss ac rms deliv via portabl light weight wearabl devic voyag contract third parti anim research organ an biotech sa special valid rat pain model ran studi independ author report subset signal demonstr statist signific effect reduc sensat pain rat model viscer pain neuropath pain inflammatori pain furthermor remov frequenc khz origin signal improv pain reduc effect unmodifi signal | D011846;D010146 | T184;T070 |
36,239,245 | boimpi base nir ii fluorophor high bright long absorpt beyond nm vivo bioimag synergist steric regul strategi fluoresc imag second near infrar nir ii nm region hold great promis vivo bioimag howev challeng develop brilliant donor acceptor donor type nir ii fluorophor maxim absorpt beyond nm aqueous solut herein report bright type boimpi base nir ii dye nk peak absorptionemiss nm vivo bioimag co assembl nk sc intermolecular steric hindranc modul dspe peg effect inhibit h aggreg nk aqueous solut enhanc bright simultan fold leverag synergist steric regul strategi notabl strategi allow deep optic penetr mm high resolut blood vessel imag vivo display high signal background ratio nm excit import boimpi base nanoprob passiv target clear visual broad type tumor xenograft improv intraop nir ii fluoresc guid resect tini metastas less mm work provid effect strategi develop boimpi base nir ii organ fluorophor broad applic | D019265;D009369 | T059;T191 |
36,239,244 | self assembl dna dendron signal amplifi dna probe base chemiluminesc assay enhanc colorimetr detect short target cdna simpl reliabl cost effect method nucleic acid detect increas interest clinic diagnost infecti genet diseas current enzym mediat method polymeras chain reaction loop mediat isotherm amplif wide use method qualit quantit diagnosi long nucleic acid sequenc high sensit howev high detect sensit short length sequenc remain signific challeng difficult primer bind sequenc previous studi demonstr simpl enzym free sequenc specif colorimetr detect nucleotid short target dna room temperatur use develop assay combin catalyt hairpin assembl cha enzym link immunosorb assay elisa mimick method follow studi aim design develop dna base signal amplifi dna dendron improv colorimetr detect short target cdna cha mediat elisa mimick assay dna dendron high branch conform synthes molecular self assembl three dna oligom assay use dna dendron demonstr enhanc detect sensit detect approxim pm nucleotid short target cdna fold higher detect limit compar obtain without dna dendron condit thus applic develop dna dendron effect signal amplifi dna probe base chemiluminesc assay potenti improv colorimetr detect short target cdna high sensit diagnosi differ diseas | D050091;D015374 | T059;T075;T104;T122 |
36,239,243 | hilli environ frequenc go home among older adult examin moder effect drive status health benefit go home frequent among older adult well known hilli environ would inhibit habit studi examin longitudin associ hilli environ frequenc go home ii moder effect drive status associ among older adult | D000203;D001334 | T056;T080 |
36,239,242 | exploit potenti lung stem cell develop pro regen therapi acut chronic lung diseas lead caus morbid mortal global unfortun diseas increas frequenc limit treatment option sever lung diseas new therapi need treat symptom slow diseas progress also enabl regener function lung tissu airway alveoli contain popul epitheli stem cell potenti self renew produc differenti progeni understand mechan determin behaviour cell interact nich allow futur generat respiratori therapi protect lung diseas onset promot regener endogen stem cell enabl regener deliveri exogen cell review summaris progress toward goal highlight challeng opportun develop pro regen bio pharmaceut gene cell therapi respiratori diseas | D008171;D033581 | T061;T047 |
36,239,241 | investig link morpholog characterist diet island popul omnivor reptil sphenodon punctatus morpholog characterist impact feed ecolog ectotherm particular reptil poor understood use morphometr measur stabl isotop analysi carbon nitrogen assess link diet function morpholog island popul evolutionarili uniqu reptil tuatara sphenodon punctatus first establish signific posit correl overal bodi size gape size fat store tuatara n next describ relationship stabl isotop profil creat whole blood nail trim sampl demonstr nail trim offer low impact method creat long term dietari profil ectotherm use nitrogen valu assess trophic level popul found tuatara takapourewa forag across multipl trophic level final found signific relationship gape size carbon linear regress p tuatara larg gape show dietari profil suggest higher intak marin seabird prey howev whether bodi size gape size primari adapt characterist allow optim forag yet unknown articl associ first person interview first author paper | D004032;D012104 | T168;T014 |
36,239,238 | bioactiv poli ether ether keton nanocomposit scaffold regul osteoblastosteoclast activ regener osteoporot bone due lower regener capac osteoporot bone treatment osteoporot defect extrem challeng clinic studi strontium dope bioactiv glass nanoparticl load sodium alendron aln name srbg incorpor poli ether ether keton matrix fabric bioactiv composit scaffold asp expect inhibit bone resorpt promot bone regener result show composit scaffold interconnect macropor could releas ca sr aln vitro prolifer alkalin phosphatas alp activ express osteogenesi relat gene format calcifi nodul rat bone marrow stromal cell rbmscs clear evidenc reduct prolifer tartrat resist acid phosphatas trap activ cell fusion express osteoclastogenesi relat gene osteoclast observ well presenc asp scaffold enhanc osteogenesi along inhibit osteoclastogenesi observ modul osteoprotegerin opg receptor activ nuclear factor b ligand rankl ratio efficaci composit scaffold regener osteoporot critic size cranial defect rat model evalu therefor bioactiv composit scaffold excel biocompat osteogen potenti could promis materi repair osteoporot bone defect | D053761;D010024 | T047;T073 |
36,239,233 | resternotomi aortic root arch replac follow previous complex type aortic dissect requir endovascular repair malperfus redo sternotomi aortic root arch replac patient follow previous complex surgic endovascular type aortic dissect repair present video case report short initi type aortic dissect repair replac ascend aorta patient develop sever viscer malperfus due compress distal true lumen underw emerg endovascular repair ascend arch descend thorac aorta stent chimney graft aortic arch vessel well fenestr intim flap abdomin aorta unfortun patient develop perman paraplegia progress symptomat sever aortic regurgit patient underw redo sternotomi aortic root arch replac explant ascend stent graft chimney stent graft antegrad cerebr perfus maintain throughout procedur aortic arch replac use terumo aortic plexus multibranch graft distal anastomos endovascular stent graft innomin left common carotid arteri reimplant onto graft aortic root replac bioconduit graft use modifi cabrol techniqu reimplant left coronari arteri satisfactori postop cours comput tomographi imag highlight feasibl high complex aortic arch repair care preoper plan | D000784;D017545;D019917;D057510 | T061;T047;T046 |
36,239,232 | organocatalyt enantioselect mannich reaction isoxazol h one isatin deriv ketimin effici organocatalyt asymmetr mannich reaction isoxazol h one isatin deriv ketimin develop bifunct squaramidebrnst base organocatalyst catalyz enantioselect mannich addit afford chiral aminooxindol bear tetrasubstitut stereocent c decor isoxazol moieti good yield excel enantioselect addit sever synthet transform describ show versatil prepar compound | D007510 | T121;T109;T130 |
36,239,225 | synthesi n substitut quaternari carbon center kot bu catalyz aza michael addit pyrazol cyclic enon studi report effici mild method synthesi cyclic amino keton contain n substitut quaternari carbon center via kot bu catalyz aza michael addit reaction pyrazol substitut cyclic enon amin promot kot bu mol ambient temperatur wide rang new versatil pyrazolyl keton obtain good yield furthermor kot bu catalyz one pot diamin cyclic dienon pyrazol via aza conjug addit follow aza conjug addit also explor | D002244;D011720 | T121;T109;T196 |
36,239,220 | microscop origin diffus dynam context transit path time distribut protein fold unfold experiment measur transit path time distribut usual analyz theoret term diffus equat free energi barrier though well understood free energi profil separ fold unfold state protein character transit mani stabl micro state exist fold unfold state justifi model transit path dynam term diffus equat name smoluchowski equat se principl van kampen shown nearest neighbor markov chain thermal jump neighbor microst lead continuum limit se friction coeffici proport mean resid time micro state howev practic question mani microst need justifi model transit path dynam term se address central topic paper compar numer result transit path base diffus equat one hand nearest neighbor markov jump model comparison transit path time distribut show one need least dozen microst obtain reason agreement two approach use markov nearest neighbor model one also obtain good agreement experiment measur transit path time distribut dna hairpin prp protein found previous use diffus equat markov chain model use also reproduc experiment measur long time tail confirm transit path barrier height k b studi indic futur attempt model experiment measur transit path time distribut one perhap prefer nearest neighbor markov model well defin also rough energi landscap studi also shed light minim number microst need unravel experiment data | D017510;D011506 | T044;T123;T116 |
36,239,215 | adapt model immun goal central toler elimin defect cell self reactiv cell self non self model danger model design understand immun respons induc model meant predict immun respons may succeed fail destroyingcontrol target howev immunolog model reli either self antigen self dendrit cell understand central toler discuss fuch matzing respons al yassin attempt address question model face come understand central toler propos goal negat select thymus elimin defect cell self reactiv cell therefor escap negat select could increas lymphopenia deplet defect nave cell outsid thymus seen elder | D061167;D013601 | T025;T042 |
36,239,214 | youth asthma experi self manag educ systemat review qualit evid identifi synthes avail evid youth asthma experi self manag educ | D000073278;D001249 | T047;T058 |
36,239,212 | aza cycloaddit employ catalyt deriv n acyliminium ion herein report develop novel rout tricycl lactam product via facil aza cycloaddit catalyt generat acyliminium ion employ ca ntf nbunpf catalyst system low load rang divers fuse ring system synthesis predomin good yield | D061565 | T067 |
36,239,209 | biomimet model fe hydrogenas featur acylphenylthiomethyl r pyridin r h ome ligand despit varieti fe h ase model prepar far structur function model studi enzym remain great challeng report new type flexibl pyridin ligand fpl base synthet method two novel fe h ase model prepar notabl two model contain biomimet fac acyl c pyridyl n thioether coordin mode also possess enzym like h activ function | D006864;D007506;D040761 | T073;T126;T116;T123 |
36,239,195 | biolog therapeut applic proton coupl folat transport proton coupl folat transport pcft slca discov princip mechan folat absorb intestin causal basi hereditari folat malabsorpt hfm found pcft high express mani tumor stimul interest use pcft cytotox drug target take advantag substanti level pcft transport acid ph condit common associ tumor | D005493;D000970;D009369 | T121;T109;T191 |
36,239,194 | reactiv argon plasma activ screen print carbon electrod high select dopamin determin dopamin da defici link sever psychiatr disord electrochem determin level da suffer abund ascorb acid aa uric acid ua bodi fluid work facil argon ar plasma treatment util enhanc electrocatalyt reactiv screen print carbon electrod spces select da detect surfac character ar treat scpes verifi carbon past binder success remov singl bond oxygen moieti oh c c generat interest sharper raman interband new key evid higher exposur carbon defect site electrochem studi reveal ar treat spces possess faster heterogen electron transfer rate larger electroact surfac area much higher conduct compar untreat electrod result oxid potenti aa da ua mixtur could well resolv current respons signific increas select determin da presenc aa ua differenti puls voltammetri gave two linear respons limit detect rang moreov ar treat spce high reproduc good storag stabil result suggest ar plasma treatment could promis method enhanc electrocatalyt properti spces detect biomolecul | D004298;D002244 | T121;T109;T123;T196 |
36,239,193 | tumor necrosi factor tnf inhibitor juvenil idiopath arthriti associ uveiti uveiti common extra articular manifest juvenil idiopath arthriti jia potenti sight threaten condit character intraocular inflamm current treatment jia associ uveiti jia u larg base physician experi observ evid consensus guidelin result consider variat practic object evalu effect safeti tumor necrosi factor tnf inhibitor use treatment jia u | D001171;D014605 | T047 |
36,239,192 | new insight fak structur function focal adhes focal adhes kinas fak also known ptk discov three decad ago recognis key player regul cell matrix adhes mesenchym cell migrat although essenti develop fak also drive invas cancer progress metastasi structur level basic build block fak describ time howev pictur fak integr larger assembl various cellular environ includ one main cellular locat focal adhes fa complex begin emerg nano resolut data cellular studi well atom structur reconstitut system provid first insight also point challeng remain obtain full structur understand fak integr fa complex structur chang occur differ stage fa matur review discuss known structur featur fak interact partner within fa environ cell membran propos initi assembl nascent fas might chang fa matur forc | D022001 | T026 |
36,239,190 | photoinduc aryl chloroaren flow synthesi unsymmetr biaryl photoflow method present radic base coupl unactiv aren aryl chlorid process proceed smooth ambient temperatur metal free condit note reaction condit fine tune chloroaren differ electron properti reactiv profil aryl chlorid general known inferior correspond iodid bromid demonstr titl protocol effici convert readili avail inexpens chloroaren unsymmetr biaryl product | D001965;D007454 | T197 |
36,239,187 | recent advanc aminoazanium salt amin reagent organ synthesi nitrogen contain organ compound wide distribut natur product pharmaceut function materi sever method report construct c n bond includ curtius rearrang schmidt rearrang ullmann reaction etc various sourc amin develop among aminoazanium salt uniqu amin precursor high oper divers structur divers reaction mode review describ synthesi aminoazanium salt discuss relationship structur reaction mode addit highlight amin reaction use aminoazanium salt | D012492;D000588 | T104;T109 |
36,239,179 | structur control releas mechan health benefit pectin encapsul materi bioactiv food compon encapsul food feed ingredi common appli avoid loss function bioactiv food ingredi compon encapsul usual sensit light ph oxygen high volatil also encapsul also appli ingredi might influenc tast mani polym natur sourc test encapsul food past year pectin propos emerg broad applic encapsul materi reason pectin versatil inexpens tailor meet specif demand provid health benefit emerg new insight chemic structur relat health benefit pectin open new avenu use pectin food feed provid insight applic potenti review current knowledg structur featur differ pectin product tailor process use microencapsul gelat impact pectin structur health benefit releas properti gut well process technolog pectin base encapsul system tailor made function review view applic pectin microencapsul differ sensit food compon although critic factor tune control releas cargo intestin impact pectin product process molecular structur pectin still need studi current insight pectin provid mani advantag encapsul bioactiv food feed ingredi cost effect | D010368;D005502 | T121;T109;T123;T168 |
36,239,175 | purifi recombin enzym effici hydrolyz conjug urinari poli phenol metabolit mani strategi use quantifi microbi poli phenol metabolit mpms urin current obtain accur result use phase ii conjug analyt standard deem gold standard howev standard expens commerci unavail quantif use afford commerci avail unconjug analyt standard follow hydrolysi crude prepar helix pomatia contain arylsulfatas glucuronidas consid altern previous studi shown poor hydrolysi effici conjug mpms work evalu effici purifi recombin enzym compar prepar h pomatia use urin sampl conjug mpms identifi hydrolysi associ unconjug mpms rapid chemic synthesi sulfat compound carri increas confid level identif sulfat mpms recombin enzym mean hydrolysi effici conjug mpms hydrolysi time min comparison prepar h pomatia achiev similar effici conjug mpms h hydrolysi compar concentr unconjug mpms releas enzymat hydrolysi recombin enzym effect almost everi mpm result demonstr accur quantif mpms urin quick achiev use purifi recombin enzym repres afford altern use conjug analyt standard improv access analysi metabol poli phenol gut microbiota | D019800;D008698 | T121;T109 |
36,239,173 | trend hospit sector consumpt awar reserv group antibiot eueea countri unit kingdom backgroundin world health organ publish st model list essenti medicin updat access watch reserv awar antibiot classif improv metric indic antibiot stewardship activ reserv antibiot regard last resort treatment optionsaimw investig hospit sector consumpt quantiti trend reserv group antibiot european unioneuropean econom area countri unit kingdom eueeauk methodshospit sector antimicrobi consumpt data obtain european centr diseas prevent control antibacteri consumpt system use anatom therapeut chemic classif atc group j includ analysi express defin daili dose ddd per inhabit per day defin reserv antibiot per awar classif appli linear regress analys trend consumpt reserv antibiot throughout studi periodresultseueeauk averag hospit sector reserv antibiot consumpt increas ddd per inhabit per day studi period p signific increas concern countri four antibiot tigecyclin colistin linezolid daptomycin constitut consumpt absolut relat total hospit sector consumpt reserv antibiot vari consider fold countri ddd per inhabit per day respect conclusionan increas trend reserv antibiot consumpt found europ substanti variat countri may reflect burden infect multidrug resist bacteria result could guid nation action optimis reserv antibiot use | D000890;D017576 | T121;T116;T195 |
36,239,171 | non pharmaceut intervent respons covid pandem european countri ecdc jrc respons measur databas respons covid pandem european unioneuropean econom area eueea countri implement wide set non pharmaceut intervent npis sometim limit knowledg effect impact popul european centr diseas prevent control ecdc european commiss joint research centr jrc develop respons measur databas ecdc jrc rmd archiv npis eueea countri januari septemb aim introduc tool wider scientif communiti assess covid npis effect impact eueea give overview ecdc jrc rmd rational structur includ brief analysi main npis appli roll covid vaccin campaign ecdc jrc rmd organis npis three level hierarch structur use four addit paramet status implement target group geograph represent provid inform implement measur featur includ readi analysi download format agil taxonomi structur highlight potenti ecdc jrc rmd facilit npi analysi optimis decis make public health respons polici | D000086382 | T047;T067 |
36,239,170 | salmonella typhimurium outbreak associ frozen tomato cube restaur western finland januari februari sever individu report gastrointestin symptom follow meal consum late januari restaur western finland conduct retrospect cohort studi defin case person ate lunch restaur januari stomach pain vomit diarrhoea andor laboratori confirm salmonella typhimurium infect within week exposur collect faecal food sampl microbiolog analysi salmonella isol characteris detail use whole genom sequenc wgs cluster analysi core genom multilocus sequenc type cgmlst altogeth meal sold peopl ate meal particip cohort studi case laboratori confirm infect multidrug resist typhimurium typhimurium isol case frozen tomato cube use uncook salad close relat cluster togeth cgmlst comparison salad consum case base cgmlst cluster suggest sourc outbreak statist associ signific eat salad case follow outbreak investig produc decid recommend cook frozen tomato product consumpt | D018551;D012486 | T007;T168;T002 |
36,239,165 | superior perform graphdiyn self power biosensor exonucleas iii assist signal amplif sensit detect microrna graphdiyn gdi sp sp co hydrocarbon allotrop whose particular structur endow mani fascin properti includ abund chemic bond high conjug natur pore high carrier mobil high conduct stabil etc work two dimension graphdiyn prepar electrod substrat materi coupl exonucleas iii assist amplif strategi construct superior perform self power biosensor base enzymat biofuel cell high sensit detect tumour marker mirna glucos oxidas god first immobil gdyaunp composit prepar bioconjug gdyaunp modifi carbon cloth use enzym biofuel cell electrod modifi bilirubin oxidas biocathod bioconjug bind god specif bind bioanod mirna present specif recognit exonucleas iii system result cleavag captur probe mirna recov involv cycl target mirna caus correspond chang open circuit voltag self power system base sensit detect method construct within scope fm nm shallow detect limit sn new approach triumphant use detect mirna serum provid compel new way earli diagnosi relat cancer | D035683;D015374 | T059;T075;T123;T114 |
36,239,147 | effect caregiv mediat intervent pilot studi children neurodevelopment disord caregiv mediat intervent cmi base parent skill train famili mediat intervent model children neurodevelopment disord particular autism spectrum disord studi aim evalu effect cmi | D000067877;D017028 | T098;T097;T099;T048 |
36,239,134 | anti cd monoclon antibodi interfer blood compat test differenti isatuximab daratumumab via function epitop map two fda approv anti cd monoclon antibodi treatment multipl myeloma isatuximab daratumumab owe express cd reagent red blood cell rbcs antibodi interfer indirect antiglobulin test iat sought understand differ interfer perform bind experi | D009101;D000970;D009447 | T191;T109;T121 |
36,239,132 | recognit stapl histon hkme peptid epigenet reader protein flexibl n termin histon tail subject numer posttransl modif includ methyl report develop stapl histon peptid bear trimethyllysin ligand epigenet reader protein stronger weaker bind affin observ stapl histon peptid relat linear histon indic select toward reader protein achiev | D006657;D010455 | T121;T123;T116 |
36,239,131 | triangular shape homolog heterostructur photocatalyt h scaveng macrophag modul rheumatoid arthriti therapi rheumatoid arthriti ra chronic arthropathi caus cartilag destruct bone eros even disabl although advanc ra treatment made base inflammatori cytokin inhibit long term treatment drug effect restrain sever side effect herein develop resveratrol rsv load agag triangular shape homolog heterostructur polyethylen glycolfol acid pegfa modif agag peg farsv nts simultan suppress inflammatori cytokin express photocatalyt h scaveng macrophag polar stimul one hand express h act pro inflammatori mediat activ mapkicam pathway exacerb inflamm elimin photocatalysi homolog ag ag heterostructur enhanc electron separ transfer act charg acceptor electron generat respect restrain electronhol recombin promot photocatalysi effici addit intrins superoxid dismutas sod catalas cat activ ag decompos reactiv oxygen speci ros express ra microenviron suppli photocatalyt h scaveng progress hand rsv natur product anti inflammatori activ could deliv inflammatori joint target effect peg fa thus inhibit ibnf b pro inflammatori pathway induc macrophag interconvers balanc expect agag peg farsv nts exhibit h scaveng capac modul macrophag polar reduc inflammatori cytokin level halt ra progress vitro vivo overal studi reveal therapeut strategi high efficaci open broad prospect ra treatment | D001172;D001688 | T121;T047;T123 |
36,239,130 | sequenc complementar depend co assembl phosphodiest link aromat donor acceptor trimer creat sequenc phosphoest link trimer aromat donoracceptor particip charg transfer interact sequenc display characterist self assembl complementari sequenc interact produc new nanostructur thermochrom pave way toward new function nanomateri make bio analog use sequenc tune structur | D049329 | T073 |
36,239,125 | probe mutual interact pseudomona aeruginosa candida albican biofabr membran base microfluid platform microb typic found multi speci polymicrobi communiti cooper competit interact speci mediat diffus factor physic contact lead high dynam communiti undergo chang composit divers size infect sever difficult treat caus multipl speci interact speci improv abil one speci toler anti microbi treatment host defens pseudomona aeruginosa pa ubiquit bacterium opportunist pathogen yeast candida albican ca frequent found togeth cystic fibrosi lung infect wound infect signific progress made determin interact pa ca still import question remain unansw probe mutual interact pa ca custom made microfluid devic use biopolym chitosan membran support cross speci communic assembl microb physic separ chemic communic popul bring direct interact mix cultur situ polymicrobi growth biofilm morpholog qualit character quantifi work reveal new dynam detail mutual interact includ cooper competit invas biofilm format membran base microfluid platform develop understand polymicrobi interact within control interact microenviron improv microbi infect prevent treatment | D011550;D002176 | T007;T004 |
36,239,124 | ductal arch decod use spatial fingerprint design norwood type patch reconstruct aortic arch norwood procedur remain focus attent term manag distal anastomosi patch design materi fashion damus kay stansel reconstruct aorta suppli coronari head neck vessel direct flow descend aorta fetus develop right ventricl shunt aorta ductal arch support great percentag system placent circul develop method design norwood patch decod dimension geometri arteri duct arch | D058327;D010920 | T018;T061 |
36,239,120 | photodegrad kinet deep learn base intellig colorimetr method bioavail base dissolv iron speciat via photodegrad dissolv iron dfe complex euphot zone releas free fe iii import sourc bioavail iron eukaryot phytoplankton urgent need establish bioavail base dissolv iron speciat bdis method herein intellig system dfe pretreat colorimetr sensor develop real time monitor newli generat fe iii ion accord photodegrad kinet dfe includ kinet constant photogener time free fe iii ion sourc kind speci dfe determin photocatalyt assist colorimetr sensor deep learn model within min algal dfe uptak day predict bdis correl coeffici could explain hard soft acid base theori hsab densiti function theori dft result success demonstr proof concept photodegrad kinet base speciat bioavail assess dissolv metal | D007501;D000077321 | T121;T066;T123;T196 |
36,239,119 | chang name diabet insipidus posit statement work group renam diabet insipidus name call rosebi name would smell sweet juliet romeo juliet william shakespear shakespear implic name noth word therefor repres convent intrins mean whilst may relev romant literatur diseas name real mean consequ medicin henc must good rational chang name diseas centuri old histor context work group repres nation intern endocrinolog nephrolog pediatr societi propos chang name diabet insipidus arginin vasopressin defici avp central etiolog arginin vasopressin resist avp r nephrogen etiolog editori provid histor context rational propos name chang | D003919;D003920 | T047 |
36,239,096 | clinic laboratori predictor fetal neonat alloimmun thrombocytopenia fetal neonat alloimmun thrombocytopenia fnait common caus intracrani hemorrhag ich thrombocytopen term infant investig clinic laboratori predictor sever fnait tertiari care referr center | D054098;D016824;D007232 | T047;T109;T129 |
36,239,095 | inpati care team view child life servic scope review util child life servic influenc interprofession collabor percept member medic team | D007297;D010348 | T101;T058 |
36,239,094 | abnorm migrat neural precursor cell famili bipolar disord cellular migrat ubiquit featur bring brain cell appropri spatial relationship time help format function brain studi migrat pattern induc pluripot stem cell deriv neural precursor cell npcs individu famili bipolar disord bd comparison healthi control bd patient also morpholog brain abnorm evid magnet reson imag time laps analysi migrat cell perform abl identifi sever paramet abnorm cellular migrat includ speed direct npcs also perform transcriptom analysi probe mechan behind aberr cellular phenotyp identifi analysi show downregul network gene center egferbb protein present find indic collect system dysregul may produc aberr cellular phenotyp could contribut function structur chang brain report bipolar disord articl associ first person interview first author paper | D001714;D058953 | T025;T048 |
36,239,092 | defin measur child youth thrive scope review promot posit child youth health develop requir clear definit comprehens measur child youth thrive studi object identifi scope rang gap definit measur thrive children youth birth young adult | D005190 | T054;T062;T099;T079 |
36,239,083 | effect arginin vasopressin transcriptom prefront cortex autist rat model previous studi also demonstr avp signific improv social interact disord stereotyp behaviour rat vpa induc autism model explor mechan action avp compar pfc transcriptom chang avp treatment vpa induc autism rat model autism model induc intraperiton inject vpa embryon day random assign two group vpa induc autism model group avp treatment group avp treatment group treat intranas avp postnat day week gene express level function chang prefront cortex measur rna seq bioinformat analysi pnd mrna express level synapt myelin develop relat gene valid qpcr result confirm avp could signific improv synapt axon dysplasia promot oligodendrocyt develop prefront cortex vpa induc autism model regul multipl signal pathway | D001321;D011297;D000067877 | T037;T048 |
36,239,074 | cardiac perform heat shock respons variat relat shell colour morph mudflat snail batillaria attramentaria gastropod exhibit remark variat shell colour within among popul function shell colour often clear present studi bodi temperatur field physiolog transcriptom respons thermal stress investig differ shell colour morph mudflat snail batillaria attramentaria use biomimet model found bodi temperatur snail dark unband shell type morph slight higher snail white line upper side whorl ul type morph expos sunlight despit differ upper lethal temperatur among shell colour morph arrhenius breakpoint temperatur abt cardiac thermal perform differ signific abt snail type morph higher snail ul type morph transcriptom analysi show type snail exhibit higher level four heat shock protein hsps ul type snail control temperatur unfold protein respons activ ul type snail type snail moder thermal stress hsps show increas ul type snail contrast hsp type snail suggest prepar defenc strategi heat shock respons type snail moder thermal stress expos subleth temperatur eight molecular chaperon uniqu upregul type snail suggest gene may allow type snail improv cardiac thermal toler result suggest prepar defenc strategi higher abt cardiac thermal perform may allow dark shell snail adapt rapid stronger thermal stress field | D018869;D049851 | T040;T039;T204 |
36,239,052 | p coordin ecm driven morphogenesi gene express three dimension mammari epitheli acini grow evid indic p encod tp crucial role normal tissu develop role canon p p isoform develop homeostasi healthi tissu remain poor understood demonstr p isoform three short isoform p respond specif laminin play import regulatori role format mammari organoid concert p demonstr modul p isoform lead chang gene express extracellular matrix molecul fibronectin fn eda fn laminin laminin human breast epitheli cell chang result increas actin stress fiber enhanc migratori behavior cell two dimension cultur found integrin coupl extracellular deposit eda fn activ akt signal pathway three dimension cultur p dysregul cell express detect p isoform express low level isoform fail form polar structur result uncov p isoform coordin express deposit organ specif ecm molecul critic mainten tissu architectur function | D016159;D005109 | T024;T123;T116 |
36,239,046 | homeschool surgeri student washington state univers longitudin integr clerkship transit hybrid virtual platform trigger covid pandem covid curtail elect surgeri colleg transit virtual platform bench surgeon statewid engag student onlin third year student complet longitudin integr clerkship lic studi onlin modul topic german surgeri week core entrust profession activ epa enter resid backbon lessonsassignmentsassess surgeon coach student around epa fifti eight student consist small group spent hoursday day pair surgeon coach line student creat uniqu hypothet caseday practic peer review epa onlin coach pose scenario drill epa preduringpost assess demonstr progress profici high level engag result attend eas recruitmentretent faculti although variabl student clinic set high virtual week aid level learn environ prior experi total surgeri exposur lic allow smooth transit virtual | D000086382;D002982;D013337 | T047;T097;T067;T065 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.