PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,238,311 | smrt ncor fine tune inflammatori versus tolerogen balanc dendrit cell differenti regul stat signal dendrit cell dc fine tune inflammatori versus tolerogen respons protect immun patholog howev role co regul maintain balanc unexplor ncor mediat repress dc immun toler recent report found deplet ncor paralog smrt ncor enhanc cdc activ express il il il concomit decreas il expressionsecret consequ co cultur cd cd cell depict enhanc thth frequenc cytotox respect compar genom transcriptom analysi demonstr differenti regul il smrt ncor smrt deplet repress mtor stat il signal cdc regul nra besid nfkbia soc regul ncor smrt deplet cdc support increas product inflammatori cytokin moreov studi mice show adopt transfer smrt deplet cdc ova dth induc footpad inflamm led increas thth reduc tumor burden b melanoma inject enhanc oncolyt cd cell frequenc respect also depict decreas ncor express rheumatoid arthriti thth diseas | D016753;D015850 | T116;T129 |
36,238,310 | hemp seed signific modul endocannabinoidom produc benefici metabol effect improv intestin barrier function decreas inflamm mice high fat high sucros diet compar linse omega fatti acid support cardiometabol health reduc chronic low grade inflamm fatti acid may impart health benefit part modul endocannabinoidom gut microbiom key regul metabol inflammatori respons whole hemp seed cannabi sativa except nutrit valu rich omega fatti acid assess effect dietari substitut equival tablespoon seed day human whole hemp seed comparison whole linse diet induc obes mous model determin effect obes gut microbiom endocannabinoidom axi show whole hemp seed substitut affect weigh gain adipos food intak wherea linse substitut associ higher fast glucos level greater insulin releas oral glucos toler test higher level liver triglycerid control furthermor hemp seed substitut mitig diet induc obes associ increas intestin permeabl circul pai level effect marker inflamm epididym adipos tissu howev increas mice fed linse hemp seed linse abl modifi express sever endocannabinoidom gene mark increas level sever omega fatti acid deriv endocannabinoidom bioactiv lipid previous suggest anti inflammatori action tissu specif manner despit relat low level seed substitut neither diet mark modifi gut microbiom mice hemp seed diet higher abund clostridiacea rikenellacea mice fed linse control diet respect thus hemp seed contain food might repres sourc healthi fat like exacerb metabol consequ obesogen diet produc intestin permeabl protect effect anti inflammatori action | D002188;D015525;D019597;D061385 | T002;T167;T121;T109;T123 |
36,238,309 | explor risk factor ischem cerebrovascular diseas system lupus erythematosus singl center case control studi ischem cerebrovascular diseas icvd one common sever complic system lupus erythematosus sle aim explor risk factor icvd sle assess associ clinic characterist | D002340;D008180;D058226;D059409;D014657 | T031;T047;T046;T020 |
36,238,308 | case report complet remiss bone metastasi renal cell carcinoma histopatholog examin treatment immun checkpoint inhibitor recent prognosi metastat renal cell carcinoma mrcc improv owe develop immunotherapi use immun checkpoint inhibitor ici howev studi therapeut effect ici bone metastas renal cell carcinoma rcc report case pulmonari humer metastas rcc signific amelior use ici surgeri patholog fractur humerus signific improv patient qualiti life qol year old man underw left nephrectomi rcc develop multipl pulmonari metastas humer metastasi patholog fractur one year surgeri combin treatment nivolumab ipilimumab initi four cours ici treatment multipl pulmonari metastas almost disappear tumor fractur site shrunk remark howev shoulder joint function decreas due fractur worsen qol therefor underw surgeri return normal daili life one month postop histopatholog examin bone soft tissu fractur site reveal malign knowledg first case report complet remiss bone metastasi rcc base histopatholog examin ici treatment | D001859;D002292;D005598;D007680;D008175 | T191;T046 |
36,238,306 | n polyunsatur fatti acid may affect cours covid high infecti coronavirus diseas covid caus sever acut respiratori syndrom coronavirus sar cov new coronavirus spread sinc late caus million death worldwid covid continu spread rapid worldwid despit high vaccin coverag therefor crucial focus prevent patient experi mild symptom covid howev case serious complic develop main due exagger immun respons call cytokin storm lead acut respiratori distress syndrom organ failur worst case death n polyunsatur fatti acid metabolit modul inflammatori respons thus reduc releas cytokin hypothes supplement n polyunsatur fatti acid could improv clinic outcom critic ill covid patient clinic trial shown administ n polyunsatur fatti acid critic ill patient improv health shorten durat stay intens care howev previous clinic studi limit therefor studi requir confirm find | D000086382;D015525 | T047;T121;T109;T123;T067 |
36,238,304 | cep novel prognost marker correl immun microenviron hepatocellular carcinoma hepatocellular carcinoma hcc respond poor standard chemotherapi target therapi henc explor novel therapeut target urgent need cep protein indispens centrosom amplif extens character hematolog malign solid tumor combin bioinformat experiment approach assess potenti cep prognost therapeut target hcc cep express increas tumor stage associ poor clinicopatholog featur frequent recurr higher mortal upon singl cell rna sequenc cep found involv prolifer self renew hepat progenitor like cell observ evidenc use cep silenc prevent tumor cell prolifer self renew arrest cell gg phase cell cycl notabl cep high correl multipl tumor associ cytokin ligand receptor axe includ il ilra il ilr il ilra could promot interact hepat progenitor like cell plvap endotheli cell tumor associ macrophag cd cell consequ cep express close associ immunosuppress tumor microenviron low immunophenoscor make potenti predictor respons immun checkpoint inhibitor taken togeth result unravel novel onco immunolog role cep establish immunosuppress tumor microenviron provid novel biomark well potenti target therapeut intervent hcc | D006528;D008113 | T191 |
36,238,303 | prophylact treatment glycyrrhiza glabra mitig covid patholog inhibit pro inflammatori cytokin hamster model netosi sever coronavirus diseas covid accompani acut respiratori distress syndrom pulmonari patholog present most inflammatori cytokin releas dysregul immun respons skew neutrophillymphocyt ratio hypercoagul state though vaccin prove effect reduc covid relat mortal limit use vaccin immunocompromis individu comorbid emerg variant remain concern current studi investig first time efficaci glycyrrhiza glabra gg extract potent immunomodul sar cov infect hamster prophylact treatment gg show protect loss bodi weight decreas lung viral load along reduc lung patholog hamster model remark gg reduc mrna express pro inflammatori cytokin plasminogen activ inhibitor pai vitro gg act potent immunomodul reduc th th differenti il il cytokin product addit gg also show robust potenti suppress ros mtros net generat concentr depend manner human polymorphonuclear neutrophil pmns murin bone marrow deriv neutrophil bmdns taken togeth provid evid protect efficaci gg covid putat mechanist insight immunomodulatori properti studi provid proof concept gg efficaci sar cov use hamster model open path studi aim identifi activ ingredi gg efficaci covid clinic case | D000086382;D006035 | T047;T067;T002 |
36,238,302 | machin learn reveal two heterogen subtyp assist immun therapi base lipid metabol lung adenocarcinoma lipid metabol pivot contribut incid develop lung adenocarcinoma luad interact lipid metabol tumor microenviron tme becom new research direct | D000077192;D008175 | T191 |
36,238,301 | dysregul autoantibodi target vaso immunoregulatori receptor post covid syndrom correl symptom sever patient post covid syndrom pcs present plethora symptom without clear evid organ dysfunct subset fulfil diagnost criteria myalgic encephalomyelitischron fatigu syndrom mecf symptom sever mecf correl natur regulatori autoantibodi aab level target sever g protein coupl receptor gpcr exploratori studi analyz serum aab level vaso immunoregulatori receptor most gpcrs pcs patient follow mild moder covid fulfil diagnost criteria mecf healthi seroneg n asymptomat post covid control n also includ studi control group found lower level various aab pcs compar least one control group accompani alter correl among aab classif use random forest indic aab target adrb stab adraa strongest classifi aab stratifi patient accord diseas outcom post covid outcom sever aab correl symptom sever pcs group remark sever fatigu vasomotor symptom associ adrb aab level pcsmecf patient studi identifi dysregul aab various receptor involv autonom nervous system an vaso immunoregul correl symptom sever point role pathogenesi pcs | D000086382;D015673 | T047;T067 |
36,238,300 | predict mutat signatur immunotherapi benefit nsclc base machin learn algorithm develop predict tool immunotherapi approach clinic import rapid emerg field routin use predict biomark inaccur may adequ util larg amount medic data machin learn promis way predict benefit immunotherapi individu data individu import featur genom data clinic characterist | D002289;D008175 | T191 |
36,238,299 | mechan under circrna dysregul tme digest system cancer circular rnas circrna new seri noncod rnas ncrnas report express eukaryot cell varieti biolog function regul cancer pathogenesi progress tme microscop ecolog environ consist varieti cell includ tumor cell immun cell normal cell ecm larg number signal molecul crosstalk circrna tme play complic role affect malign behavior digest system cancer herein summar mechan under aberr circrna express tme digest system cancer includ immun surveil angiogenesi emt ecm remodel regul tme circrna expect new therapeut method | D004067;D000079962 | T191;T114 |
36,238,298 | enough half nfat haploinsuffici two patient epstein barr virus suscept transcript factor nuclear factor activ cell nfat pivot immun regul function induc osmot stress tonic independ signal | D020031;D051359 | T047 |
36,238,297 | recent advanc car cell therapi colorect cancer colorect cancer crc third common cancer high mortal rate serious impact peopl life health recent year adopt chimer antigen receptor car cell therapi shown well efficaci treatment hematolog malign still mani problem challeng solid tumor crc exampl tumor immunosuppress microenviron low target car cell short time car cell vivo limit prolifer capac car cell car cell effect infiltr tumor new approach propos address challeng crc review provid comprehens overview current state car cell therapi crc | D015179;D000076962 | T191;T192;T116;T129 |
36,238,296 | post transcript regulatori feedback encod jak stat signal memori interferon stimul immun cell fine tune respons infect inflammatori cue use live cell confoc microscopi mathemat model investig interferon induc jak stat signal innat immun macrophag demonstr transient exposur ifn stimul induc long term desensitis stat signal gene express respons reveal dose time depend regulatori feedback control jak stat respons upon exposur stimulus show ifn elicit differ level desensitis ifn cell refractori ifn sensit ifn vice versa experiment demonstr under feedback mechan involv regul stat phosphoryl independ new mrna synthesi cognat receptor express new feedback model protein tyrosin phosphatas activ recapitul experiment data demonstr jak stat network abil decod relat chang dose time type tempor interferon stimul find reveal stat desensitis render cell signal memori type ii interferon stimul futur may improv administr interferon therapi | D016898;D011505 | T121;T126;T116;T129 |
36,238,295 | excretorysecretori protein inhibit host immun respons downregul tlrnf bmapk signal pathway possibl mechan immun evas parasit nematod haemonchus contortus haemonchus contortus import parasit nematod rumin previous studi show h contortus escap immun complex mechan includ releas excretorysecretori protein esp modul host immun respons howev detail mechan h contortus excretorysecretori protein hcesp promot immun evas remain unknown present studi demonstr hcesp inhibit adapt immun respons goat includ downregul immun cell antigen present upregul immun checkpoint molecul activ statpd l pathway activ immunosuppress regulatori treg cell furthermor hcesp revers lps induc upregul pro inflammatori mediat pbmcs inhibit tlrnf bmapksnlrp signal pathway studi provid better understand evas mechan h contortus could help provid altern way prevent infect parasit | D006189 | T204 |
36,238,294 | nlrp role ischemiareperfus injuri nlr famili pyrin domain contain nlrp express immun cell especi dendrit cell macrophag act constitu inflammasom protein act pattern recognit receptor identifi pathogen associ molecular pattern addit recognit pathogen associ molecular pattern recogn damag associ molecular pattern trigger nlrp inflammasom molecul atp releas injur cell result activ inflammatori cytokin il il abnorm activ nlrp inflammasom demonstr stimul inflammatori metabol diseas thus nlrp regard proper target decreas activ nlrp inflammasom recent studi also shown abnorm activ nlrp ischemiareperfus ir injuri current review focus role protein ir injuri gastrointestin neurovascular cardiovascular system | D058847;D015427 | T123;T116;T037 |
36,238,293 | nkp natur killer cell develop activatedmemori like phenotyp contribut innat immun experiment filari infect lymphat filariasi onchocerciasi major neglect tropic diseas affect million peopl worldwid pain profound disfigur patholog lymphoedema blind type inflamm hallmark filari nematod tissu infect implic eosinophil depend immun lymphat ocular immunopatholog type innat lymphoid cell ilc known play import role initi type inflamm helminth infect therefor track compar il r ilc st ilc nkp natur killer nk innat lymphoid cell popul expans brugia malayi experiment periton filari infect use either immunocompet immunodefici mice immunocompet balbc anim nkp nk cell rapid expand repres ilc popul first week infect wherea surpris st ilc fail expand nkp nk cell expans confirm rag defici mice lack adapt immun ablat nkp nk cell compart rag common gamma chain gc mice led increas suscept chronic adult b malayi infect data recapitul use onchocerca ochengi male worm periton implant model nkp nk cell deplet rag defici mice use anti nkp asialo gm antibodi inject first five week b malayi infect suscept adult b malayi infect signific increas fold concomit impair eosinophil neutrophil recruit final demonstr rag defici mice drug clearanc primari adult b malayi infect follow challeng infect lead resist earli larval b malayi establish innat resist associ bolster nk eosinophil wherebi nkp nk cell express marker memori likeenhanc activ increas express interferon gamma lyc data promot novel function role nkp nk cell immunoprotect experiment primari secondari filari infect proceed absenc adapt immun regul | D007113;D007371 | T121;T116;T032;T129 |
36,238,292 | express phagocyt receptor x control riam vasp vinculin neutrophil differenti hl cell activ integrin phagocyt receptor cr cdbcd cr x cdccd requir rap activ riam function riam control integrin activ recruit talin subunit enabl talin vinculin interact term bridg integrin actin cytoskeleton riam also recruit vasp phagocyt cup facilit vasp phosphoryl function promot particl intern use crispr cas knockout approach analyz requir riam vasp vinculin express neutrophil hl cell knockout cell display abolish phagocytosi accompani signific specif reduct itgam itgax x itgb mrna reveal rt qpcr riam vasp vinculin kos present reduc cellular f actin content correl express treatment actin filament polymer stabil drug jasplakinolid partial restor express general express x less respons jasplakinolid treatment indic regulatori mechan independ f actin content may involv serum respons factor srf investig potenti transcript factor control express sinc coactiv mrtf requir actin polymer induc transcript immunofluoresc mrtf local parent cell primarili nuclear knockout exhibit diffus cytoplasm pattern local fhl srf corepressor main sub membran parent hl cell knockout local dispers cytoplasm nucleus suggest riam vasp vinculin requir maintain fhl close cytoplasm membran reduc nuclear local inhibit corepressor activ final reexpress vasp vasp knockout result complet revers phenotyp knock in restor express taken togeth result suggest riam vasp vinculin necessari correct express x neutrophil differenti human promyelocyt hl cell line strong point involv protein acquisit phagocyt phenotyp | D000199;D016608 | T123;T116 |
36,238,291 | structur new glycyrrhiza polysaccharid immunomodulatori activ compon licoric polysaccharid gps extract licoric primari structur identifi character first time immunomodulatori activ studi crude licoric polysaccharid isol purifi deae sepharos ff ion exchang column chromatographi chromdex pg gel filtrat column chromatographi obtain purifi glycyrrhiza polysaccharid name gps nmr methyl analysi reveal gps compos homogalacturonan hg type pectin galpa backbon studi gps also examin signific role regul immun activ vitro vivo result gps promot secret ifn il mice increas proport cd cd cd cd lymphocyt spleen dendrit cell dcs treat gps show promot dc matur antigen present phagocyt capac result suggest gps potenti immunomodul stimul immun system regul multipl signal pathway combin character primari structur gps present investig provid basi futur studi form function relationship polysaccharid | D006035;D014315 | T109;T002 |
36,238,290 | identifi hub circadian rhythm biomark immun cell infiltr rheumatoid arthriti rheumatoid arthriti ra chronic system autoimmun diseas symptom character typic circadian rhythmic chang studi aim identifi hub circadian rhythm gene crgs ra explor associ immun cell infiltr pathogenesi ra | D001172;D053263 | T047;T044 |
36,238,289 | immun microenviron landscap show treatment specif differ rectal cancer patient neoadjuv therapi cornerston modern rectal cancer treatment insight biolog tumor respons essenti success implement organ preserv strategi differ treatment may lead specif tumor respons studi aim explor treatment specif respons tumor microenviron patient local advanc adenocarcinoma rectum receiv neo adjuv chemotherapi ct neo adjuv radiochemotherapi rct neo adjuv radiotherapi long interv lrt short interv srt neoadjuv therapi nt control includ multiplex immunofluoresc perform determin presenc cytotox cell cyt cdcd regulatori cell reg cdfoxp helper cell helper cdcd foxp b cell cd dendrit cell cdc tumor cell panck total rectal cancer patient includ treatment group match gender tumor locat respons therapi tnm stage pattern respons shrinkag vs fragment howev differ treatment group analys reveal rct treat patient exhibit lower stromal helper reg cyt cell compar treatment regimen conclus demonstr treatment specif differ immun microenviron landscap rectal cancer patient understand under mechan landscap specif therapi benefit futur treatment decis | D012004 | T191 |
36,238,288 | microrna diagnost biomark tuberculosi systemat review meta analysi earli diagnosi tuberculosi use novel non sputum base biomark high prioriti end tb strategi microrna mirna signific regul tb pathogenesi differenti express pattern among healthi latent activ tb popul reveal potenti biomark recent studi thus systemat review perform meta analysi role host mirna tb diagnosi also review involv mirna immun respons mycobacterium tuberculosi mtb | D035683;D009169;D014376 | T007;T047;T123;T114 |
36,238,287 | time evolut cytokin profil associ mortal covid hospit patient high cytokin level associ sever covid diseas although mani cytokin studi perform mani includ combinatori analysi cytokin profil time studi investig associ certain cytokin profil evolut mortal sar cov infect hospit patient | D000086382 | T047;T067 |
36,238,286 | deregul hyaluronan metabol tumor microenviron drive cancer inflamm tumor associ immun suppress hyaluronan ha known promin compon extracellular matrix tumor mani solid cancer character aberr ha metabol result increas product tumor tissu ha implic regul varieti cellular function tumor cell tumor associ stromal cell suggest alter ha metabol influenc tumor growth malign multipl level import increas ha product cancer associ enhanc ha degrad due high level express activ hyaluronidas hyal understand complex molecular cellular mechan involv abnorm ha metabol catabol solid cancer could import implic design futur cancer therapeut approach appear extens crosstalk immun cell ha enrich stroma contribut tumor growth progress sever way specif interact tumor recruit hyal express myeloid deriv suppressor cell mdscs bone marrow origin ha produc cancer associ fibroblast epitheli tumor cell result enhanc ha degrad accumul small pro inflammatori ha fragment drive cancer relat inflamm addit hyaluronan enrich stroma support transit tumor recruit hyal mdscs pd l tumor associ macrophag lead format immunosuppress tolerogen tumor microenviron review aim discuss contribut tumor associ ha cancer inflamm angiogenesi tumor associ immun suppress also highlight recent find relat enhanc ha degrad tumor microenviron | D009369;D059016 | T191;T070 |
36,238,285 | use person prognosi treatment relaps multipl sclerosi practic guid clinic cours multipl sclerosi ms high variabl among patient thus creat import challeng neurologist appropri treat monitor patient progress despit patient appar similar symptom sever ms diseas onset prognos may differ great end believ proactiv disposit part neurologist identifi prognost red flag earli diseas cours lead much better long term outcom patient term reduc disabl improv qualiti life present prognosi tool form checklist clinic imag biomark paramet base consensus literatur clinic experi establish associ poorer improv clinic outcom neurologist encourag use tool identifi presenc absenc specif variabl individu patient diseas onset therebi implement suffici effect treatment strategi appropri address like prognosi patient | D009103 | T047 |
36,238,284 | cannabinoid receptor attenu neuroinflamm promot autophagi mediat degrad nlrp inflammasom post spinal cord injuri neuroinflamm follow spinal cord injuri sci result prolong neurolog damag locomotor dysfunct polar microglia vital regul neuroinflamm although under mechan yet elucid endocannabinoid receptor subtyp cbr report amelior neurodegener via immunomodul activ howev under machineri context sci remain unclear | D058847;D013119 | T123;T116;T037 |
36,238,283 | practic aspect chimer antigen receptor cell administr commerci point care manufactur chimer antigen receptor cell target cd antigen achiev impress result patient relapsedrefractori rr b cell malign lead approv european union jurisdict spain academ anti cd cart cell product varnimcabtagen autoleucel var cel ari cell extraordinarili approv hospit exempt claus treatment patient older year age rr acut lymphoblast leukaemia var cel also grant prioriti medicin design european medicin agenc indic review reveal practic aspect relat prepar administr academ point care cart cell product use var cel exampl put context commerci product | D000076962 | T192;T116;T129 |
36,238,282 | whole cell vaccin candid induc protect respons virul acinetobact baumannii acinetobact baumannii caus multi system diseas nosocomi set pre dispos general popul bacterium desicc resist also notori resist multipl antibiot drug last resort includ carbapenem colistin sulbactam world health organ categor carbapenem resist baumannii top critic pathogen list bid direct urgent countermeasur develop sever earli stage vaccin shown rang efficaci healthi mice vaccin candid advanc clinic trial herein report find ioniz radiat inactiv non ioniz ultraviolet c inactiv whole cell vaccin candid protect neutropen mice pulmonari challeng virul ab particular pathogen isol addit demonstr humor respons suffici protect via passiv immun neutropen mice | D000151;D040981 | T007;T047 |
36,238,281 | bifidobacterium animali kv lactobacillus vaginali fn allevi lactoglobulin induc allergi modul dendrit cell mice food allergi serious public health problem high incid risk probiot induc immun regul patient allerg diseas mechan fulli clear paper lactoglobulin lg sensit mice use model explor mechan bifidobacterium animali kv kv lactobacillus vaginali fn fn reduc allerg reaction regul immun cell function result show oral administr kv fn signific reduc score allerg symptom hypothermia symptom serum level lg specif immunoglobulin e lg sige histamin mast cell proteas allerg mice flow cytometri analysi intestin dendrit cell dcs show proport cdcmajor histocompat complex mhc iidc cdccddcs cdc cddcs increas kv fn intervent indic strain induc immatur dcs decreas antigen present capac dcs meanwhil toll like receptor tlr nf b signal pathway activ dcs secret interleukin il signific increas interleukin il decreas dcs kv fn intervent indic dcs potenti promot cell differenti helper type th cell furthermor proport cdcd ifn cell spleen increas cdcd il cell decreas oral administr kv fn correct helper type th skew immun respons result indic kv fn reduc lg induc allerg symptom mice suggest two potenti probiot might use altern therapeut agent mitig food allergi | D000069982;D005512 | T007;T046 |
36,238,280 | efficaci immun checkpoint inhibitor therapi egfr mutat posit patient nsclc brain metastas fail egfr tki therapi treatment option avail brain metastas bms egfr mutant non small cell lung cancer nsclc progress prior egfr tyrosin kinas inhibitor egfr tki therapi studi aim evalu efficaci immun checkpoint inhibitor ici therapi patient | D001932;D002289;D008175 | T191 |
36,238,279 | identif four immun subtyp local advanc rectal cancer treat neoadjuv chemotherapi predict efficaci subsequ immun checkpoint blockad neoadjuv chemoradiotherapi ncrt foundat treatment local advanc rectal cancer larc ncrt improv efficaci immunotherapi situ vaccin effect | D016609;D012004 | T191 |
36,238,278 | mechan strategi immunotherapi resist colorect cancer colorect cancer crc third common cancer world although standard treatment option crc patient respond poor treatment immunotherapi gradual emerg due increas awar understand tumor immun exhibit good therapeut efficaci various cancer immunotherapi includ cytokin immun checkpoint inhibitor ici adopt cell therapi particular ici antibodi cytotox lymphocyt associ protein ctla program cell death pd ligand pd l success appli clinic solid tumor reliev inhibitori effect tumor microenviron cell howev minor patient cancer achiev durabl clinic respons immunotherapi sever factor restrict efficaci immunotherapi lead develop drug resist review aim discuss current status immunotherapi crc elabor mechan mediat resist immunotherapi potenti therapeut strategi | D060890;D015179 | T191;T116;T129 |
36,238,277 | clinic valu indirect immunofluoresc screen anti rod ring antibodi retrospect studi two center china investig distribut clinic signific rod ring rr pattern various diseas | D000163;D006526;D008107;D008171 | T047;T033 |
36,238,276 | utr sar cov spike gene hijack host mir mir h disturb cell prolifer cytokin signal sever acut respiratori syndrom coronavirus sar cov becom global public health threat recent studi focus sar cov rna design vaccin drug demonstr virus rna could play spong host noncod rnas regul cellular process bioinformat research predict seri motif sar cov genom target human mirna studi use dual luciferas report assay valid interact utr sar cov utr gene bioinformat predict target mirna growth cell huvec overexpress utr determin mirna il tnf level check condit mir mir mimic introduc cell huvec overexpress utr respect reveal under regul mechan result screen mirna target utr includ mir mir cell utr could inhibit cell growth regul mir reduc mir utr could induc huvec cell prolifer alter cell cycl reduc apoptosi enhanc il tnf level conclus sar cov rna could play spong host mirna disturb cell growth cytokin signal suggest import clue design covid drug vaccin | D000086382;D035683 | T047;T123;T067;T114 |
36,238,275 | ox agonist stimul increas sustain humor cell mediat respons sar cov protein sarna vaccin prevent sar cov infect generat long last immun vaccin need generat strong viral specif b cell respons previous result lab other shown immun presenc ox agonist antibodi lead higher antibodi titer increas number long live antigen specif cd cd cell use similar strategi explor effect ox co stimul prime boost vaccin scheme use adjuv sar cov spike protein vaccin cbl mice result show ox engag vaccin signific increas long live antibodi respons spike protein addit immun spike protein specif prolifer great increas cd cd cell enhanc spike specif secret ifn il booster rd inject immun combin ox agonist month post prime increas vaccin specif antibodi cell respons initi experi assess self amplifi mrna sarna vaccin encod spike protein antigen show robust antigen specif cd cell respons sarna spike specif cd cell express high level grzmb ifn tnf observ protein immun respons increas ox agonist similar protein immun ox agonist also increas vaccin specif cd cell respons summari studi compar contrast effect benefit protein sarna vaccin extent ox agonist enhanc sustain immun respons sar cov spike protein | D000086382;D014612 | T047;T116;T121;T129;T067 |
36,238,273 | pattern recognit receptor cd gene polymorph alcohol use disord patient influenc liver diseas suscept alcohol use disord aud lead liver diseas major concern spectrum disord excess alcohol consumpt result leaki gut syndrom attribut alcohol induc liver injuri portal transloc bacteri endotoxin suscept alcohol liver diseas ald aud patient could depend upon gene respons inflamm alcohol metabol pattern recognit receptor cd gene major player endotoxin mediat inflamm suscept ald studi investig genet associ cd polymorph mechan relev alter inflammatori respons lead ald | D000437;D008108 | T047;T048 |
36,238,271 | covid vaccin hesit associ factor among infertil coupl undergo assist reproduct treatment although periconcept vaccin import matern neonat health littl known covid vaccin hesit among infertil coupl seek fertil treatment thus conduct survey among infertil patient reproduct medicin center septemb decemb estim preval covid vaccin hesit influenc factor inform collect face face interview among volunt among includ interviewe report hesit primari vaccin report hesit booster vaccin delay primari vaccin hesit primari vaccin associ unexplain infertil ci ongo ivf treatment ci concern vaccin safeti ci effect ci influenc pregnanc ci factor also associ hesit booster vaccin delay primari vaccin invers associ colleg degre ci previous histori influenza vaccin ci posit associ concern influenc pregnanc ci necessari carri target educ program health profession public benefit periconcept vaccin reduc resist covid vaccin among infertil coupl | D000086382;D007246 | T047;T046;T067;T033 |
36,238,260 | complianc level toward covid prevent measur associ factor among ambo univers communiti coronavirus ill high contagi viral infect serious health consequ occur around world applic covid prevent precaut social intervent general public critic success combat epidem therefor studi aim determin level complianc associ factor covid prevent strategi | D000086382 | T047;T067 |
36,238,259 | home fit satisfact model chines resid covid pandem base sem analysi respons covid epidem china propos take epidem opportun cultiv resid healthi live habit meet demand healthi live base relev research review theoret analysi concept model home fit satisfact chines resid construct research hypothesi test sem conceptu model modifi final model home fit satisfact chines resid obtain result show epidem period chines resid enthusiasm home fit remain unchang onlin servic provid power social support home fit environ still enhanc space | D000086382;D010549 | T047;T041;T067;T033 |
36,238,258 | massiv health educ technolog mediat analys impact syphili epidem brazil syphili case rise brazil declar epidem address consequ public health crisi ministri health laid rapid respons plan name syphili project snp nation instrument fight diseas encompass four dimens manag govern b surveil c comprehens care strengthen educommun dimens educ snp develop learn pathway syphili sexual transmit infect stis strengthen promot health educ pathway featur massiv open onlin cours mooc deliv virtual learn environ brazilian health system avasus paper analyz impact learn pathway syphili stis respons epidem brazil highlight educ process learn pathway social implic perspect unit nation agenda sustain develop goal three distinct databas use organ educ data learn pathway syphili stis avasus nation registri healthcar facil brazilian ministri health moh brazilian occup classif ministri labor analysi provid comprehens descript cours learn pathway enrol particip brazilian region especi southeast account highest number enrolle addit worth note student live abroad also enrol cours data character provid demograph studi focus cours particip profess level care practic reveal major work primari secondari healthcar practition target audienc learn pathway accord part personnel direct engag healthcar servic fight syphili epidem brazil | D012749;D013587 | T047 |
36,238,257 | comparison covid season influenza differ intens non pharmaceut intervent vaccin effect covid pandem last year global epidem prevent control situat remain challeng scientif decis make great signific peopl product life well effect epidem prevent control therefor import explor pattern put forward countermeasur pandem respiratori infect | D000086382;D007252;D007251 | T047;T121;T109;T129;T067 |
36,238,255 | toler three common administ covid vaccin healthcar profession healthcar institut requir employe vaccin sar cov mani also requir least one booster | D000086382;D000086663 | T047;T200;T067 |
36,238,254 | studi interact differ pathogen hand foot mouth diseas five region china studi aim explor interact differ pathogen hand foot mouth diseas hfmd use mathemat epidemiolog model report data five region china | D004770;D004769;D006232 | T047;T005 |
36,238,253 | associ extrem precipit hospit acut myocardi infarct beij china time seri studi context global climat chang increas extrem weather event arous great public concern limit evid focus associ extrem precipit hospit acut myocardi infarct ami studi aim examin effect extrem precipit ami hospit | D006760;D009203 | T047;T058 |
36,238,252 | perform evalu machin learn comput code verbal autopsi ccva algorithm caus death determin compar analysi data rural south africa comput code verbal autopsi ccva algorithm common use determin caus death cod questionnair respons extract verbal autopsi vas howev oper structur data effect har inform unstructur va narrat machin learn ml algorithm also appli success determin cod va narrat allow use auxiliari inform ccva algorithm direct util howev ml base studi use respons structur questionnair result lack generalis compar across studi present compar perform evalu ml method ccva algorithm south african va narrat data use data agincourt health demograph surveil site hdss physician classif gold standard data collect case random forest extrem gradient boost classifi outperform classifi combin dataset attain accuraci respect signific statist differ algorithm perform p model attain area receiv oper characterist auroc greater interva ccva attain caus specif mortal fraction accuraci overal chanc correct concord demonstr ml model could accur determin caus death va narrat addit mortal trend pattern analysi discov first decad civil registr system south africa averag life expect approxim year howev second decad life expect signific drop popul die much younger averag age year most lead hiv relat caus interest third decad see gradual improv life expect possibl attribut effect health intervent programm structur semant analysi narrat expert disagre also demonstr frequent term tradit healer consult visit compar approach also make studi baselin use futur research enforc general compar futur studi entail explor deep learn model cod classif | D000465;D000069550 | T170;T066 |
36,238,251 | access understand promot mainten good health evalu knowledg transfer peopl intellectu disabl bridg health inform diseas prevent public health import patient empower among peopl intellectu disabl id steadili grow yet multipl health health literaci challeng still make popul vulner health dispar inadequ access essenti health basic servic lack involv health educ research crucial factor contribut inequ greater effort must made includ peopl id health literaci communic research preliminari focus languag includ pictori languag communiti case studi aim document experi answer pilot questionnair evalu problem peopl mild moder id accord icd result show patient acquir health inform physician medic profession prepar appropri questionnair special educ teacher give valuabl insight howev particip easili distract need support focus questionnair easi read languag simpl format big font presenc confidenti caretak need indic semi structur interview train interview might suitabl measur knowledg transfer peopl id result case studi highlight need develop appropri questionnair emphas need continu dialogu peopl id healthcar provid | D057220;D008607 | T041;T048 |
36,238,250 | determin neonat mortal among neonat admit neonat intens care unit dessi comprehens special hospit northeast ethiopia unmatch case control studi accord world health organ neonat mortal defin death babi within first day live newborn period vulner period child surviv bulk neonat death occur first day week accord recent studi third newborn death occur within first day life near three quarter occur within first week studi aim assess determin neonat mortal among neonat admit neonat intens care unit dessi comprehens special hospit northeast ethiopia | D007035;D007363 | T093;T073;T037;T033 |
36,238,249 | rhein inhibit chlamydia trachomati infect regul pathogen host cell global incid genit chlamydia trachomati infect increas rapid primari avail treatment c trachomati infect use antibiot howev develop antibiot resist stain treatment failur often observ patient consequ novel therapeut urgent requir rhein monom deriv anthraquinon compound anti infect activ studi investig effect rhein treat c trachomati infect rhein show signific inhibitori effect growth c trachomati multipl serovar c trachomati includ e f l various host cell includ hela mccoy vero rhein could direct inactiv c trachomati could inhibit growth c trachomati regul pathogen host cell interact combin azithromycin inhibitori effect rehin synergist vitro vivo togeth find suggest rhein could develop treatment c trachomati infect | D002690;D002692 | T007;T047 |
36,238,248 | construct three level enter nutrit nurs system internet medic mode evalu effect clinic applic studi aim explor construct three level enter nutrit nurs system internet medic mode clinic applic effect | D004750;D020407 | T061;T074;T170;T073 |
36,238,247 | bibliometr analysi human monkeypox research novel prevent control strategi sinc human monkeypox report mani relat literatur publish studi aim evalu research hotspot futur develop trend human monkeypox bibliometr analysi analyz prevent control measur various countri respons human monkeypox outbreak | D004785;D045908;D012900 | T121;T047;T131;T129 |
36,238,246 | cross section associ screen time select lifestyl behavior adolesc adolesc excess screen time lead mani advers health outcom associ varieti lifestyl behavior studi conduct investig associ two type screen time varieti lifestyl behavior american adolesc | D005247;D000077705 | T055;T040;T079 |
36,238,245 | knowledg hivaid transmiss mode attitud toward hivaid infect peopl level hivaid awar among general popul kingdom saudi arabia cross section studi human immunodefici virus hiv acquir immunodefici syndrom hivaid worldwid public health issu sinc saudi arabia grow access outsid world critic analyz general popul knowledg hivaid transmiss mode attitud toward hivaid infect peopl level hivaid awar therefor studi aim assess knowledg hivaid transmiss mode attitud toward hivaid infect peopl well level hivaid awar among general popul kingdom saudi arabia | D000163;D015658 | T047 |
36,238,244 | improv earli childhood develop context nurtur care framework kenya polici review qualit explor emerg issu polici maker nurtur care framework ncf describ nurtur care abil nation communiti support caregiv provid environ ensur children good health nutrit protect threat provid opportun earli learn respons emot support interact assess extent kenyan govern polici address compon ncf explor policydecis maker view polici gap emerg issu | D002657;D057766 | T170;T040;T039 |
36,238,243 | respect matern care among women gave birth public hospit hadiya zone southern ethiopia compassion respect care pregnanc childbirth one essenti compon safe motherhood howev women develop countri experi disrespect abus matern care childbirth henc studi assess status respect matern care associ factor bridg gap | D008427 | T058 |
36,238,242 | paediatr biobank health ethic legal societ landscap biobank play central role pediatr translat research deal primarili genet data sampl base research howev particip children biobank receiv limit attent literatur even though research general clinic trial particular long histori involv minor resolv explor specif challeng ethic legal societ issu elsi current pediatr biobank landscap propos way forward biobank children partner research methodolog first establish access util pediatr biobank main europ support literatur review relat children particip take account academ paper also relev guidelin best practic find discuss five theme general vulner ethic issu balanc risk benefit right open futur return result includ secondari find legal issu capac legal major societ issu public awar empower respons research children ultim observ go shift parentsguardian consent sine qua non condit posit minor agreement confirm minor particip parent guardian ethic rethink pave way toward age appropri dynam participatori model involv minor decis make howev identifi requir dynam tool assess matur lack co produc engag tool pauciti share best practic highlight need provid empower capabl set support research biobank back practic exampl conclus equip children adult appropri tool ensur children particip forefront respons pediatr biobank ethic oblig cornerston research integr | D018070;D012108 | T093;T097 |
36,238,241 | preval prolong grief disord symptom chines parent lost child systemat review meta analysi parent lost child second child shidu larg popul china prolong grief disord pgd shidu parent clinic public health concern report pgd preval vari wide facilit plan grief counsel servic meta analysi estim preval pgd symptom identifi subgroup elev risk pgd | D009863;D000090382 | T099;T048 |
36,238,240 | spatial tempor analysi liver cancer mortal yunnan provinc china liver cancer major public health challeng publish studi report tempor trend geograph distribut liver cancer mortal china especi less develop southwest region higher liver cancer incid current studi obtain liver cancer mortal data popul base death surveil system yunnan provinc mortal liver cancer analyz use joinpoint regress model space distribut liver cancer mortal counti district yunnan provinc illustr use arcgi softwar moran method use estim global local spatial autocorrel liver cancer mortal analyt result reveal averag mortal rate liver cancer yunnan provinc averag annual growth rate p higher liver cancer mortal found rural area male moreov peopl age year experienc steep increas liver cancer mortal rate high high cluster main consist area higher hepat virus infect rate sever intraven drug use problem studi result suggest heavi burden liver cancer southwest china yunnan provinc comprehens intervent measur need develop implement | D008113 | T191 |
36,238,239 | mental health impact covid saudi famili children special educ need disabl saudi arabia nation perspect covid pandem reveal multidimension impact mental health due health concern social distanc lockdown job loss limit institut support accord covid may disproport impact famili special educ need disabl send due alreadi high preval mental health condit children send parent henc essenti determin short term impact pandem mental health famili send identifi ongo health includ psycholog wellb support need current studi examin anxieti level concern children send parent live saudi arabia | D000086382 | T047;T067 |
36,238,238 | predictor e cigarett initi use among middl school youth low incom predomin hispan communiti e cigarett use among middl high school youth increas million million becom common tobacco product use among youth hispan youth largest ethnic minor unit state higher rate tobacco use includ e cigarett non hispan identifi factor put youth risk futur e cigarett use vital focus prevent effort inform social cognit theori studi identifi predictor e cigarett uptak among e cigarett nave youth predomin low incom hispan communiti | D066300;D000072137 | T055;T073 |
36,238,237 | associ circadian rhythm cortisol shift work regular among midwiv multicent studi southeast china articl aim explor associ trend cortisol rhythm regular shift work among midwiv | D008880;D000073577 | T091;T097;T057 |
36,238,236 | societ vulner context popul age percept healthcar student saudi arabia healthcar profession import role increas awar protect popul natur disast studi aim assess percept healthcar student toward societ vulner context popul age | D013338 | T097 |
36,238,235 | physic activ covid pandem vojvodina serbia physic activ pa youth adult popul underw chang last year due coronavirus covid pandem purpos maintain health popul purpos studi estim level pa youth popul adult popul young old covid pandem territori vojvodina serbia determin differ well compar result result pandem | D000086382 | T047;T067 |
36,238,234 | supplementari privat health insur supplement health china advoc health insur system social health insur shi main bodi privat health insur phi supplement studi phi complementari role health conduc provid evid phi polici expans encourag public particip phi insuffici china | D054624;D017149 | T098;T057;T080 |
36,238,233 | studi endoscop submucos dissect past year bibliometr analysi endoscop submucos dissect esd advanc minim invas techniqu en bloc resect superfici gastrointestin lesion drawn increas attent emerg bibliometr analysi evalu origin current hotspot research trend esd | D001471;D000069916 | T061;T047 |
36,238,232 | behavior intent adopt mobil health servic moder impact mobil self efficaci studi explor moder impact mobil self efficaci adopt mobil health servic utaut use theoret foundat studi result indic mobil self efficaci signific moder impact perform expect p effort expect p mobil self efficaci howev found signific predict citizen intent recommend adopt mobil health servic p implic find mobil health discuss | D033182;D017216 | T058;T041 |
36,238,196 | semaglutid may allevi hepat steatosi tdm combin nfald mice via mir abhd although pathogenesi non alcohol fatti liver diseas nafld extens studi role under pathogenesi remain unclear current approv therapeut strategi nafld purpos studi observ benefici effect semaglutid nafld vivo vitro well potenti molecular mechan | D003924;D035683;D065626 | T047;T123;T114 |
36,238,195 | current perspect evid date btk inhibitor manag multipl sclerosi multipl sclerosi ms chronic inflammatori diseas central nervous system lead demyelin neurodegener basic translat studi shown b cell myeloid cell critic player develop cours diseas bruton tyrosin kinas btk essenti b cell receptor mediat b cell activ normal b cell develop matur addit role b cell btk also involv sever function myeloid cell although signific number diseas modifi treatment dmts approv clinic use ms patient novel target therapi studi refractori patient patient progress form diseas basi role b cell myeloid cell btk inhibitor provid attract therapeut benefit ms articl review main effect btk inhibitor differ cell type involv pathogenesi ms summaris recent advanc develop btk inhibitor novel therapeut approach differ ms clinic trial avail data regard efficaci safeti drug describ | D009103;D047428 | T121;T047;T116 |
36,238,131 | relationship among insulin therapi insulin resist sever coronari arteri diseas type diabet mellitus effect insulin therapi coronari arteri diseas cad remain controversi studi aim analyz associ insulin resist morbid sever cad type diabet mellitus tdm | D003324;D003924;D007333;D062645 | T061;T047;T046 |
36,237,993 | valu diffus weight dynam contrast enhanc imag diagnosi thymic epitheli tumor background thymic epitheli tumor tet clinic frequent encount neoplasm prevascular mediastinum adult role chest magnet reson mr imag increas stress thank excel contrast resolut freedom ioniz radiat capabl provid addit inform regard tumor cellular structur vascular method studi aim establish relationship mr find patholog classif tet focus diffus weight dw dynam contrast enhanc dce imag retrospect cross section studi includ tet patient underw chest mr scan tumor classifi three group accord classif low risk thymoma lrt high risk thymoma hrt non thymoma nt along morpholog characterist appar diffus coeffici adc valu time intens curv tic pattern time peak enhanc ttp tumor record compar three group result smooth contour complet almost complet capsul suggest lrts median adc valu tumor mm sec among three group lrts highest adc valu nts lowest differ adc valu three group statist signific p use adc cutoff mm sec differenti lrts tumor two remain group area curv sensit specif accuraci washout type tic pattern preval account popul pattern also predomin observ lrts although median ttp lrts lower hrts nts statist signific differ found ttps three group p conclus mr good imag modal preoper assess tet morpholog featur adc valu tic pattern ttp help preoper predict tet patholog | D009375 | T191 |
36,237,992 | normalis high bone remodel due oestrogen defici tradit chines formul kang shuai lao pian ovariectomis rat postmenopaus osteoporosi transpir due excess osteoclast bone resorpt insuffici osteoblast bone format presenc oestrogen insuffici kang shuai lao pian kslp red ginseng base tradit chines medicin known anti age properti howev studi effect bone loss lack thus current studi examin skelet protect effect kslp ovariectomis rodent bone loss model three month old femal spragu dawley rat n randomis baselin sham ovariectomis ovx group ovx rat supplement low kslp l gkg medium kslp gkg high dose kslp kslp h gkg calcium carbon wv daili supplement kslp perform via oral gavag eight week gavag stress stimul ovariectomis control distil water rat euthanis end studi whole bodi femor bone miner content densiti scan perform baselin everi four week blood sampl obtain determin bone remodel marker histomorphometri biomechan strength test perform femur tibia high bone remodel typic due oestrogen defici indic elev bone format resorpt marker osteoclast surfac singl label surfac mineralis surfacebon surfac ratio observ untreat ovx rat whole bodi bmd adjust bodi weight young modulus decreas signific untreat ovx rat high dose kslp supplement counteract degen chang conclus kslp improv bone health normalis bone remodel therebi prevent bone loss decreas bone strength caus oestrogen defici anti osteoporosi effect valid patient postmenopaus osteoporosi | D001862;D015663 | T047;T042 |
36,237,991 | interact effect obes cognit function declin risk chronic kidney diseas progress patient type diabet mellitus year cohort studi background obes cognit function declin independ risk factor chronic kidney diseas ckd howev studi examin combin effect obes status cognit function chang ckd risk aim evalu associ obes status cognit function ckd risk chang patient type diabet mellitus tdm method data tdm patient extract diabet diseas manag program univari multivari analys use assess associ obes cognit declin ckd risk chang three index includ relat excess risk interact reri attribut proport interact api synergi index si use analyz interact ckd risk classifi accord kdigo ckd definit result multivari analysi hazard ratio hr cis ckd risk progress time higher moder sever obes patient compar normal weight patient time higher patient mini mental state examin mmse score compar mmse score synergist interact moder sever obes mmse score ckd risk progress si ci proport ckd risk progress caus interact api ci howev normal weight mmse score benefici ckd risk improv patient moder risk high risk stage ckd conclus may synergist interact obes cognit function declin synergist interact may increas risk ckd progress | D060825;D003924;D051436 | T047;T048 |
36,237,990 | effect dexmedetomidin diaphragm activ measur ultrasonographi spontan breath patient background diaphragm movement well correl inspir volum lung dexmedetomidin dex less effect respiratori function sedat object studi investig diaphragmat movement use ultrasound us dex infus sedat spontan breath patient undergo unilater upper limb surgeri method total consecut patient enrol studi patient sedat use dex ipsilater axillari brachial nerv plexus block diaphragmat activ evalu use diaphragmat thicken end inspir tei diaphragmat thicken end expir tee diaphragmat thicken fraction dtf measur diaphragmat us three time point baselin dex sedat dex recoveri supplementari oxygen appli simpl mask lmin peripher oxygen satur spo end tidal co etco respiratori rate rr record result tei tee show signific chang studi period p p respect dtf maintain p recoveri dex infus discontinu dtf increas although increas statist signific vs p spo remain etco remain mmhg desatur episod observ studi period conclus result studi show dex sedat affect diaphragmat movement situat decreas rr induc dex find impli dex induc sedat result clinic signific respiratori depress | D020927 | T121;T109 |
36,237,989 | atranorin driven nano materi spion lead ferroptosi gastric cancer stem cell weaken mrna hydroxymethylcytidin modif xc gpx axi express gastric cancer high malign tumor gastric cancer stem cell gcscs main caus drug resist metastasi recurr poor prognosi secondari metabolit lichen atranorin varieti biolog effect antibacteri anti inflammatori analges wound heal howev kill effect gcscs report studi construct atranorin complex compris superparamagnet iron oxid nanoparticl spion atranorin spion vitro vivo experi confirm atranorin spion could signific inhibit prolifer invas angiogenesi tumorigen cd cd gcscs induc oxid stress injuri fe accumul ferroptosi quantit real time revers transcript pcr western blot result show atranorin spion reduc express level gcsc stem cell marker cell prolifer divis marker also signific inhibit express level key molecul cystineglutam transport xc glutathion peroxidas gpx tet methylcytosin dioxygenas tet famili protein result high perform liquid chromatographi mass spectrometri dot blot show atranorin spion signific inhibit mrna hydroxymethylcytidin modif gcscs meanwhil result rna immunoprecipit pcr also indic atranorin spion signific reduc hydroxymethylcytidin modif level gpx slca mrna untransl region gcscs result decreas stabil shorten half live reduc translat activ therefor studi reveal atranorin spion induc ferroptosi gcscs weaken express xc gpx axi hydroxymethylcytidin modif mrnas pathway therebi achiev therapeut effect gastric cancer | D049308;D000079403;D013274 | T191;T043;T126;T116 |
36,237,988 | insight exosom intervertebr disc emerg role disc homeostasi normal function low back pain lbp chronic condit caus great individu suffer econom burden major contributor lbp intervertebr disc degener idd caus spectrum homeostasi alter includ apoptosi nucleus pulposus np annulus fibrosus af cell degrad extracellular matrix ecm calcif cartilagin endplat cep current therapeut strategi idd includ conserv surgeri treatment nevertheless none could revers progress destruct intervertebr disc henc pivot pursu new therapeut approach exosom nano size substanc diamet nm synthes secret various type cell play import role intercellular communic increas evid implic exosom could impact intracellular transcript activ therebi inhibit acceler prolifer apoptosi cell thus new therapeut sourc idd review chiefli focus general clarifi role exosom onset deterior idd therapeut potenti | D055354;D007403;D055959;D000070614 | T026;T190;T023;T047 |
36,237,987 | matern thtreg cytokin small extracellular vesicl plasma potenti biomark preeclampsia preeclampsia one serious pregnanc complic may caus immunolog chang earli placent microenviron content small ev may serv biomark pregnanc complic evid suggest balanc helper th regulatori treg cell critic prevent preeclampsia studi recruit pregnant women preeclampsia healthi pregnant women assess level th treg cytokin il il il il tgf plasma small ev found signific differ level cytokin plasma two group second trimest also observ signific differ two group level ev encapsul cytokin il il tgf well total small ev second trimest roc analysi show classif effici auc tgf small ev tgf best discrimin abil singl ev biomark test cross valid accuraci th treg cytokin plasma small ev may contribut matern immun activ clarifi potenti mechan small ev cytokin preeclampsia | D000067128;D011225 | T026;T046 |
36,237,986 | comparison bronchial blocker doubl lumen tube patient undergo lung resect propens score match cohort studi object aim studi compar effect bronchial blocker bb doubl lumen tube dlt patient postop recoveri lung resect method patient undergo lung resect receiv either bb dlt intub review match use propens score match method primari outcom surgic durat secondari outcom includ diagnost result postop chest x ray postop oxygen index incid hypercapnia hypoxemia sore throat chest tube durat incid icu admiss length hospit stay incid day readmiss result match patient receiv bb match patient receiv dlt statist differ surgic durat two group p howev compar dlt group patient bb group show infiltr especi surgeri side versus p base chest x ray togeth higher incid icu admiss versus p conclus compar dlt patient receiv bb techniqu tend increas pulmonari infiltr especi surgeri side higher incid icu admiss earli post oper stage may influenc patient recoveri | D010612;D019616 | T061;T047;T184 |
36,237,985 | analysi efficaci autolog peripher blood stem cell transplant high risk neuroblastoma object studi aim analyz efficaci autolog peripher blood stem cell transplant high risk neuroblastoma china method data high risk neuroblastoma patient treat cccg nb regimen review baselin clinicopatholog characterist prognosi analyz compar addit prognos tandem autolog stem cell transplant singl autolog stem cell transplant group compar result result surviv analysi show autolog peripher blood stem cell transplant base pretreat regimen signific improv prognosi children high risk group year event free surviv ef overal surviv os rate transplant group nontransplant group vs p vs p respect differ distribut baselin clinic case characterist singl transplant group tandem transplant group p signific differ ef os two group p conclus base pretreat programm autolog peripher blood stem cell transplant safe toler signific improv prognosi children high risk group valu tandem autolog stem cell transplant worthi discuss consid various aspect transplant medic regimen patient state | D018380;D009447;D036102 | T191;T061 |
36,237,984 | superfici venous associ inflamm direct iv administr rrx rat rrx small molecul nlrp inflammasom inhibitor anti cd antiangiogenicvascular normal properti phase clinic trial design drug devic combin fda phase first man dose escal clinic trial rrx given direct intraven iv infus main advers event steril pain infus phlebiti ip less pain experienc rrx infus slower rate multipl hour impract outpati basi phase reason conveni safeti rrx co administ aliquot autolog blood ex vivo devic call eloop premis rrx bind hemoglobin red blood cell rbcs make unavail direct interact venous nociceptor phlebiti potenti progress deep venous thrombosi septic thrombophleb post thrombot syndrom hypercoagul immunosuppress cancer patient week toxicolog studi week iv rrx administr wistar han rat follow recoveri period day main observ toxic signific inflammatori respons vein wall consist superfici venous thrombosi observ man due develop direct iv infus rrx relat contraind favor co administr autolog blood | D058847;D010689 | T047;T046;T123;T116 |
36,237,895 | case allerg coronari syndrom kouni syndrom know kouni syndrom ks acut coronari syndrom occur allerg hypersensit anaphylact anaphylactoid reaction associ mast cell activ entail signific morbid mortal risk present four case acut coronari syndrom develop insect bite chemotherapi coronari stent implant two patient lost due anaphylact shock relat multiorgan failur sudden cardiac death sinc wide rang drug food environment condit diseas state may associ ks physician must awar syndrom | D054058;D000707;D000074962 | T047;T046 |
36,237,894 | possibl diseas protect role fibroblast cancer fibrosi therapeut applic cancer fibrot diseas character continu inflamm tissu wound injuri cancer wound heal uncontrol prolifer cancer cell disrupt normal tissu integr induc stromal fibroinflammatori reaction fibroblast prolifer extens stroma play major role develop diseas consider evid fibroblast contribut fibrosi tissu stiffen promot diseas progress via multipl mechan howev recent emerg find main deriv singl cell transcriptom analysi indic fibroblast function heterogen lead hypothesi diseas promot restrain fibroblast exist recent show fibroblast popul defin express glycosylphosphatidylinositol anchor membran protein meflin may suppress promot fibrot respons diseas progress cancer fibrot diseas although current hypothet primari function meflin posit fibroblast may tissu repair injuri cancer initi occur observ led propos potenti therapi convert phenotyp fibroblast pro tumor anti tumor short review summar recent find function meflin context cancer fibrot diseas discuss util knowledg fibroblast translat medicin also discuss sever aspect interpret surviv analysi data kaplan meier analysi address function specif gene express fibroblast | D017261;D009369 | T191;T109;T123 |
36,237,893 | relationship chang physic function paramet roland morri disabl questionnair score decompress surgeri lumbar spinal canal stenosi although decompress surgeri lumbar spinal canal stenosi lss improv leg symptom low back pain lbp disabl factor relat improv subject disabl studi suffici purpos studi clarifi relationship subject disabl object physic function paramet total patient underw decompress includ evalu preoper month postop patient report outcom relat activ limit due lbp evalu use roland morri disabl questionnair rdq vas visual analog scale physic function assess use min walk distanc mwd trunk muscl strength univari analysi multivari linear regress analysi perform identifi signific factor rdq score chang month postop rdq score vas score trunk extensor strength signific improv relat preoper valu univari analysi age chang vas lbp leg pain numb score chang mwd associ rdq score chang p multivari linear regress show mwd chang signific associ rdq score chang explain varianc rdq score chang studi show chang mwd signific associ rdq score chang result suggest improv mwd may reduc disabl activ daili live | D019299;D013130 | T061;T020 |
36,237,892 | effect new interact web teach materi improv lung auscult skill random control trial clinic nurs develop new interact web base teach materi improv lung auscult skill object investig effect web base teach materi nurs less one year work experi use prospect open label stratifi block random control trial particip particip assign web base paper base control intervent group respect use simul discrimin test seven lung sound normal wheez rhonchi coars crackl fine crackl left lung diminish right lung absent conduct next post test conduct one week train answer formal name consid correct common name misspel without left right part consid insuffici wrong answer consid incorrect control group show signific differ pre test post test lung sound paper base group show signific improv perform wheez p coars crackl p web base group show signific improv perform fine crackl p number correct answer post test higher paper web base group control group p web base teach materi develop effect improv abil new graduat nurs auscult lung sound addit result suggest combin use web paper base teach materi may effect sinc sound method enhanc abil auscult differ lung sound | D001314;D012135 | T060;T184;T201;T033 |
36,237,891 | spontan regress asymptomat tumefact perivascular space anterior tempor lobe perivascular space fluid fill space surround perfor vessel brain normal find brain imag usual asymptomat consid manifest age perivascular space occasion undergo signific enlarg refer tumefact perivascular space often indistinguish neoplast lesion spontan regress tumefact perivascular space follow rare report imag find clinic cours patient show spontan regress tumefact perivascular space anterior tempor lobe togeth literatur review discuss regard characterist pathogenesi spontan regress tumefact perivascular space studi avail literatur report tumefact perivascular space anterior tempor lobe view characterist anterior tempor lobe tumefact perivascular space may differ tumefact perivascular space occur locat | D008279;D013702 | T023;T059;T060;T029;T170 |
36,237,890 | upper thorac empyema concomit superior vena cava syndrom treat reconstruct surgeri use pedicl oment flap superior vena cava svc syndrom refer constel symptom secondari obstruct blood flow svc condit venous blood usual drain svc divert inferior vena cava ivc via collater vein reconstruct surgeri challeng case owe anomal venous system case report describ reconstruct surgeri use pedicl oment flap patient upper thorac empyema concomit svc syndrom year old man underw resect malign thymoma bilater brachiocephal vein part right upper lobe follow polytetrafluoroethylen ptfe graft placement venous system reconstruct year prior present develop postop upper thorac caviti empyema necessit ptfe graft remov although infect control month multipl right upper lobe pulmonari fistula persist patient refer depart evalu contrast enhanc comput tomographi reveal svc syndrom character svc obstruct consequ drainag venous blood upper trunk ivc via collater vessel debrid necrot infect tissu pedicl oment flap place upper lobe fistula coverag patient show uncompl postop cours recurr empyema pulmonari fistula observ year postop flap associ svc system show high venous pressur use pedicl oment flap deem feasibl graft reach upper thorax even though associ ivc system | D016724;D019651;D013479 | T061;T047 |
36,237,889 | relationship sleep effici lifestyl evalu object sleep assess sleep epidemiolog project univers tsukuba object measur sleep effici recent shown associ health problem although sever factor previous report associ sleep effici studi conduct older younger adult factor associ sleep effici healthi worker remain unknown aim studi investig relationship sleep effici lifestyl factor use sleep measur data record activ meter worn worker total worker male mean age year recruit five offic sleep measur period week actigraphi worker attribut lifestyl habit occup stress identifi use questionnair associ sleep effici lifestyl occup stress attribut explor logist regress analysi logist regress analysi use attribut occup stress adjust variabl reveal longer sleep hour weekend weekday odd ratio confid interv ci water ingest bedtim ci smartphon use bedtim ci associ decreas sleep effici studi found lifestyl habit associ sleep effici among worker necessari verifi whether intervent lifestyl habit would contribut improv sleep effici futur studi | D008019;D012890 | T054;T047;T040;T033 |
36,237,887 | patient factor influenc delay diagnosi pediatr spinal cord tumor diagnosi pediatr spinal cord tumor frequent delay due presenc non specif symptom investig factor influenc delay first symptom present diagnosi pediatr spinal cord tumor retrospect analyz patient age year men women underw surgeri spinal cord tumor singl center extract relev data patient symptom affect spinal locat cervic c thorac lumbosacr l tumor anatom locat extradur intradur extramedullari intramedullari tumor could potenti affect durat symptom present prior diagnosi common symptom present patient pain n motor symptom paralysi associ earli diagnosi p durat symptom prior diagnosi found signific longer patient spinal tumor lumbar sacral region involv cervic thorac region month vs month p month vs month p respect studi result demonstr pain common symptom examin patient although affect delay diagnosi wherea present motor symptom help diagnosi pediatr spinal cord tumor diagnosi could delay lumbar sacral spinal tumor | D013120;D013125 | T191 |
36,237,886 | satisfactori mid long term clinic radiograph outcom surgic treatment radial neck fractur children complic surgic treatment pediatr radial neck fractur common purpos studi evalu mid long term clinic radiograph outcom surgic treatment pediatr radial neck fractur assess children surgic treat radial neck fractur main perform percutan intrafoc pin reduc fractur inappropri perform open reduct mid long term clinic radiograph outcom assess well whether affect patient relat outcom hand questionnair final follow patient seven boy mean age year age rang year four fractur right hand side six left four grade ii iii two grade iv accord judet classif mean follow time rang year eight patient restrict forearm pronat mean radial neck angul fractur side rang preoper rang final follow eight case radial head overgrowth three prematur physeal closur two notch radial neck one heterotop ossif accord leungpeterson classif four patient excel three good three fair function eight patient perfect score upon complet hand questionnair conclus postsurg patient relat outcom case satisfactori despit slight restrict forearm rang motion complic detect use radiographi | D004551;D011885 | T030;T037 |
36,237,885 | effect serratus anterior plane block thorac paravertebr nerv block analgesia immun function serum tumor marker patient thoracoscop radic resect lung cancer aim assess effect serratus anterior plane block sapb thorac paravertebr nerv block tpvb analgesia immun function serum tumor marker patient thoracoscop radic resect lung cancer total patient enrol februari novemb prospect select random divid group n control group receiv general anesthesia induct general anesthesia tpvb sapb group given tpvb sapb clinic data oper condit visual analogu scale vas score immun function serum tumor marker advers reaction compar tpvb sapb group lower dosag sufentanil oper later time first press patient control intraven analgesia pca pump oper smaller number press pca pump within h oper control group p vas score rest cough decreas h oper tpvb sapb group compar control group p cluster differenti cd cd cd cd ratio higher cd lower h oper tpvb sapb group control group p tpvb sapb group lower serum tumor marker level h oper control group p sapb tpvb mark improv postop analges effect enhanc immun function decreas serum tumor marker level patient receiv thoracoscop radic resect lung cancer without increas advers reaction howev tpvb may punctur pleura | D008175;D009407 | T191;T061 |
36,237,884 | patholog signific classif endolymphat hydrop otolog disord summar presenc endolymphat hydrop eh otolog disord evalu magnet reson imag mri tempor bone propos classif eh base patholog signific search literatur publish english languag journal perform use electron databas especi focus eh relat otolog disord clinic articl contain term eh contrast mri publish present relev human tempor bone studi includ follow three main point discuss base result relev articl otolog disord present eh ii current grade evalu eh mri iii propos classif eh base patholog signific mri evalu reveal eh exist extens ear typic menier diseas md also various otolog disord etiolog classif eh help summar idea determin pathophysiolog otolog disord therapeut classif provid clue manag mri evalu eh led breakthrough investig eh otolog disord precis grade evalu clarif eh mri base patholog signific could provid key elucid pathophysiolog eh relat otolog disord | D018159;D008575 | T047 |
36,237,883 | paraplegia due spinal epidur lipoma without spinal dysraph adolesc patient case report report case rare lipoma aris epidur space year old boy without spinal dysraph lipoma rare pediatr soft tissu tumor account case incid intraspin epidur lipoma without spinal dysraph extrem rare pediatr patient case patient progress motor deficit lower extrem difficulti urin defec magnet reson imag show extradur tumor compress spinal cord level progress neurolog deficit perform emerg surgeri tumor complet resect en bloc histopatholog reveal matur adipos tissu fibrous septa diagnos atyp lipomat tumor well differenti liposarcoma patient fulli recov tumor recurr year sinc surgeri howev examin use fluoresc situ hybrid year surgeri chang diagnosi lipoma amplif murin doubl minut type oncogen observ liposarcoma histopatholog diagnosi use fluoresc situ hybrid mandatori case illustr immunohistochem diagnosi alon mislead henc prompt surgeri requir progress neuropathi | D008067;D008080;D016135 | T191;T019 |
36,237,882 | associ serum carotenoid prematur mortal popul base case control studi carotenoid abund pigment main contain veget fruit show antioxid properti quench free radic human bodi studi investig associ serum carotenoid level prematur mortal object studi investig associ serum carotenoid level prematur mortal japanes popul studi includ japanes adult men age recruit particip japan collabor cohort jacc studi serum carotenoid level measur high perform liquid chromatographi prematur mortal defin death year old follow period prematur mortal ascertain men women men compar st tertil serum cryptoxanthin provitamin rd tertil lower risk prematur caus mortal ci cryptoxanthin provitamin women compar st tertil serum cryptoxanthin rd tertil higher risk prematur caus mortal ci signific associ observ analys prematur cancer mortal found signific associ higher level serum cryptoxanthin provitamin lower risk prematur mortal among japanes men differ direct associ found women although find suggest role serum carotenoid prematur mortal studi need valid associ popul | D000072743;D002338 | T121;T109;T127;T123 |
36,237,881 | finger nose test improv diagnosi cerebrovascular event patient present isol dizzi emerg depart difficult identifi patient isol dizzi caus cerebrovascular event estim risk cerebrovascular event isol dizzi patient complet understood aim evalu associ finger nose test fnt diagnos cerebrovascular event isol dizzi patient emerg depart ed combin dataset singl center consecut isol dizzi patient inclus exclus criteria met follow criteria exclud fnt data age year psycholog trauma primari outcom cerebrovascular event defin cerebr stroke due cerebr infarct cerebr hemorrhag vertebr arteri dissect transient ischem attack combin dataset patient complain isol dizzi cerebrovascular event adjust previous report risk factor cerebrovascular event age hypertens hyperlipidemia diabet mellitus nystagmus multivari logist model analysi show exist fnt abnorm signific associ cerebrovascular event odd ratio confid interv p signific increas predict accuraci auc increas roc analysi p exist fnt abnorm consid strong risk factor could use predict cerebrovascular event isol dizzi patient recommend fnt screen isol dizzi patient ed judg whether need undergo diagnost evalu | D002546;D020521 | T047 |
36,237,880 | children neuro development disord center child adolesc mental health cambodia center child adolesc mental health ccamh one center psychiatr specialist children cambodia studi aim understand characterist children neuro development disord especi autism spectrum disord asd ccamh studi includ case random chosen new patient ccamh age year socio demograph factor parent inform obstetr factor clinic data collect patient record logist regress analysi pearson chi squar test use compar characterist children final diagnos asd other non asd patient male year old diagnos asd common symptom delay speech play alon hyperact asd signific preval male patient compar femal year age group compar year age group parent live phnom penh high educ like visit ccamh children diagnos asd regard treatment approxim half patient famili counsel psychosoci educ asd patient speech therapi special educ structur teach network coordin therapi compar non asd patient provid educ therapi children asd parent earli stage inform center asd wide distribut parent cambodia | D000067877 | T048 |
36,237,879 | effect month walk program biochem paramet sedentari adult type diabet mellitus studi assess effect month walk program biochem paramet patient type diabet mellitus group sedentari patient type diabet volunt particip studi plasma glucos triglycerid total cholesterol low densiti lipoprotein cholesterol ldl high densiti lipoprotein cholesterol hdl aspart aminotransferas ast alanin aminotransferas alt gamma glutamyl transferas urea creatinin uric acid c reactiv protein crp erythrocyt sediment rate measur differ outcom measur pre post intervent assess use pair test wilcoxon sign rank test effect size interpret separ normal small moder larg non normal distribut data r small moder larg signific p larg decreas initi final measur observ glucos r total cholesterol triglycerid r ldl r ast alt gamma glutamyl transferas urea creatinin r uric acid r crp erythrocyt sediment rate hand signific p larg increas initi final measur observ hdl r supervis month aerob walk program effect strategi reduc hyperglycemia increas hdl reduc ldl triglycerid reduc plasma biomark liver dysfunct kidney dysfunct inflamm type diabet patient | D003924 | T047 |
36,237,877 | challeng left sleev pneumonectomi left later decubitus posit report case year old woman carin adenoid cystic carcinoma underw left sleev pneumonectomi left later decubitus posit sever desatur encount transect left main bronchus left lung select intub ventil howev oxygen inadequ henc venoarteri extracorpor membran oxygen ecmo introduc initi barclay procedur plan preserv left lung plan alter due extent tumor unstabl ventil lesion remov trachea right main bronchus anastomos end end left pneumonectomi right lung select ventil oxygen satur spo drop despit ecmo spo improv addit ventil left lung use anoth breath circuit temporari right chest closur perform ventil left lung across thoracotomi wound patient turn semi supin posit toler select right lung ventil ecmo subsequ left thoracotomi pneumonectomi success perform care manag requir desatur left sleev pneumonectomi left later decubitus posit | D008175;D011013 | T191;T061 |
36,237,876 | achiev good neurolog outcom combin decompress craniectomi acut subdur hematoma transarteri embol intraperiton injur arteri multipl sever trauma case report year old woman jump th floor apart attempt commit suicid whole bodi comput tomographi show multipl injuri includ right acut subdur hematoma left hemopneumothorax sever fractur intraperiton hemorrhag spleen injuri conscious deterior rapid right pupil dilat furthermor unstabl vital sign includ blood pressur approxim mmhg puls minut respiratori rate minut percutan oxygen satur l oxygen intratrach intub insert thoracostomi tube perform emerg room due concomit brain herniat hemorrhag shock simultan decompress craniectomi acut subdur hematoma transarteri embol intraperiton injur arteri perform hybrid oper room despit rapid blood transfus blood pressur increas start embol injur arteri spleen blood pressur increas therebi make possibl remov acut subdur hematoma hemostasi achiev four hour later acut subdur hematoma intracrani pressur increas oper perform normal oper room cranioplasti clavicular fractur reduct perform day later recov enough talk walk conscious stabil interview famili psychiatrist determin abnorm behavior first appear month earlier diagnos acut transient psychot disord treatment start patient discharg home month later mild disabl higher order brain function | D056424;D020199;D009104 | T061;T046;T037 |
36,237,829 | correl hepat copper level rhodanin score histolog diagnosi archiv canin liver sampl liver main storag site copper excess copper accumul howev risk factor develop chronic hepat dog mass spectrometri rhodanin stain frequent use method assess copper level liver associ studi analyt hepat copper level rhodanin score archiv canin formalin fix paraffinembed liver section various diagnos thirti six n liver sampl analyt interpret toxic n high normal n normal n copper level select studi rhodanin stain sampl grade scale associ determin actual liver copper level rhodanin score histolog diagnos chronic hepat diagnos analyt copper level rhodanin score signific higher p sampl design toxic compar normal signific associ hepat copper level rhodanin score p rhodanin score actual liver copper level signific p associ chronic hepat versus diagnos rhodanin score statist signific predictor chronic hepat conclud studi actual liver copper level posit associ rhodanin score rhodanin score use predictor chronic hepat | D004283;D012236 | T047;T109;T130 |
36,237,828 | valid icd ptsd complex ptsd north korean defector use intern trauma questionnair background intern trauma questionnair itq self report assess focus core featur post traumat stress disord ptsd complex post traumat stress disord cptsd consist organ principl th revis intern classif diseas icd sinc number north korean defector nkd enter south korea escap human right violat increas rapid nkd settl south korean govern face import challeng support nkd success adapt settl south korean societi nkd experi various traumat event process defect repatri therefor essenti understand psycholog disord nkd especi ptsd cptsd object studi aim test valid itq assess explor differ symptom qualiti life ptsd cptsd method studi sampl compris trauma expos nkd confirmatori factor analysi cfa latent class analysi lca use evalu valid itq one way analysi varianc post hoc analys reveal differ depress somat symptom scale dsss whoqol bref result among ptsd cptsd symptom lca class result cfa lca result support icd conceptu ptsd cptsd nkd cfa result confirm first second order model statist fit communiti dwell nkd first order model better model fit second order model lca find reveal four class model ptsd cptsd dso low symptom class compar ptsd class cptsd class higher level depress somat symptom lower qualiti life conclus studi provid evid itq valid tool assess ptsd cptsd communiti dwell nkd | D000071896;D013313 | T184;T048 |
36,237,827 | trajectori psychosoci symptom wellb asylum seeker refuge expos traumat event resettl western europ turkey uganda background longitudin studi examin mental health trajectori refuge asylum seeker scarc object investig trajectori psycholog symptom wellb refuge asylum seeker identifi factor associ trajectori method asylum seeker refuge control arm three trial europ n turkey n uganda n includ describ trajectori psycholog symptom wellb use trauma exposur age marit status educ individu trial predictor assess bidirect interact wellb psycholog symptom effect predictor outcom control baselin valu result symptom improv identifi trial wellb particip europ turkey versus uganda europ turkey domest violenc predict increas symptom post intervent ci whilst murder famili member month follow ci lower wellb predict murder famili member ci kidnap ci close death ci host countri year ci uganda post intervent kidnap predict increas symptom ci lack shelter ci domest violenc predict lower wellb ci conclus mani particip adapt advers contextu factor play critic role determin mental health trajectori | D012036;D013313 | T098;T048 |
36,237,826 | intens outpati treatment ptsd open trial combin prolong exposur therapi emdr physic activ background intens outpati treatment could promis option patient post traumat stress disord ptsd object aim studi test effect eight day two week intens treatment ptsd within public health care set open trial design method eighti nine patient offer choic intens treatment space individu treatment chose intens format patient assess self report batteri interview pre treatment start treatment post treatment three month follow day consist individu prolong exposur therapi eye movement desensit reprocess therapi group psychoeduc physic activ therapist rotat patient result patient show clinic signific chang recoveri symptom ptsd effect size larg patient also show reduct symptom depress anxieti along improv well interperson function chang social work function ambigu dropout attend high patient high satisfi treatment conclus intens programm attract effect treatment option patient ptsd | D057169;D007171;D013313 | T061;T048 |
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