PMID
int64
35.7M
36.4M
Title/Abstract
stringlengths
22
8.78k
MeshTerms
stringlengths
7
101
SemanticTypes
stringlengths
4
64
36,227,598
associ attent deficithyperact disord diagnosi adolesc qualiti life appropri diagnosi attent deficithyperact disord adhd improv short term outcom children adolesc littl known associ diagnosi qualiti life qol
D001289
T048
36,227,597
impact vape prevent advertis us adolesc random clinic trial understand whether prevent advertis reduc suscept vape import owe concern level adolesc vape
D000073865;D066300;D000072137
T055;T073
36,227,596
factor associ patient receiv oral anticanc drug oral anticanc drug oacd increas prescrib cancer treatment requir signific coordin care retrospect studi suggest oacd prescript never receiv patient reason behind poor understood
D000970;D009369
T121;T109;T191
36,227,595
effect front packag inform fruit imageri high ad sugar warn label parent beverag choic children random clinic trial fruit drink wide consum young children mani parent mistaken believ drink healthi potenti due front packag claim imageri research need influenc market label regul could chang behavior
D005515;D000073893
T121;T068;T057;T109
36,227,594
analysi sever ill postvaccin covid breakthrough among adult without hiv us understand sever postvaccin sar cov ie covid breakthrough ill among peopl hiv pwh inform vaccin guidelin risk reduct recommend
D000086382;D000086663;D015658
T047;T200;T067
36,227,593
effect exercis train complex mental social activ cognit function adult chronic stroke random clinic trial stroke doubl one risk dementia promot cognit function among person chronic stroke unclear
D003704;D020521
T047;T048
36,227,592
comparison qualiti measur us hospit physician vs nonphysician chief execut offic patient experi patient safeti major domain health care qualiti howev empir data associ physician vs nonphysician chief execut offic ceo public privat qualiti measur rare critic evalu hospit increas seek physician ceo
D010820;D019984
T097;T081;T080
36,227,591
admp regul tail bend control ventral epiderm cell polar via phosphoryl myosin local ciona ventral tail bend transient pronounc found mani chordat embryo constitut interest model tissu interact control embryo shape identifi one key upstream regul ventral tail bend embryo ascidian ciona show earli tailbud stage ventral epiderm cell exhibit boat shape morpholog boat cell narrow apic surfac phosphoryl myosin light chain pmlc accumul show interf function bmp ligand admp led pmlc local basal instead apic side ventral epiderm cell reduc number boat cell final show cut ventral epiderm midlin cell apex use ultraviolet laser relax ventral tail bend base result propos previous unreport function admp local pmlc apic side ventral epiderm cell caus tail bend ventral resist antero posterior notochord extens ventral side tail
D002938;D000077262
T204
36,227,589
egfr signal transduct downregul c elegan vulval precursor cell dauer diapaus caenorhabd elegan larva display development plastic respons environment condit advers condit second stage larva enter revers long live dauer stage instead proceed reproduct adulthood dauer entri interrupt vulval induct associ reprogram like event preserv multipot vulval precursor cell vpcs allow vulval develop reiniti condit improv vulval induct requir lin egf like signal gonad activ egfr ras erk signal transduct nearest vpc pp use biosensor live imag show egfr ras erk activ downregul pp dauer investig process use gene mutat transgen manipul differ step pathway analyz let egfr subcellular local dauer life histori found respons egf attenu upstream ras activ discuss potenti membran associ mechan could achiev also describ find pertain mainten vpc compet quiescenc dauer larva analysi indic vpcs l like uniqu dauer stage featur rather featur l vpcs continu develop
D029742;D000074767
T040;T116
36,227,588
year opportunist mammograph screen scenario brazil impact breast cancer earli detect nationwid popul base studi mammograph screen use reduc breast cancer mortal worldwid remain main modal earli detect diseas women low middl incom countri still lack access period mammogram effici health care cross section studi aim explor opportunist mammograph coverag brazil consid privat insur popul associ earli breast cancer ebc detect
D001943;D055088
T191;T058;T060
36,227,587
reform need modern us food drug administr oversight dietari supplement cosmet diagnost test jama forum discuss long await reform could modern us food drug administr regulatori process promot innov provid us consum greater assur product use safe reliabl
D003358;D003955
T060;T167;T073
36,227,586
high resolut ribosom profil reveal translat select transcript bovin preimplant embryo develop high resolut ribosom fraction low input ribosom profil bovin oocyt preimplant embryo enabl us defin translat landscap earli embryo develop unpreced level analyz transcriptom polysom non polysom bound rna profil bovin oocyt germin vesicl metaphas ii stage earli embryo two cell eight cell morula blastocyst stage reveal four mode translat select select translat non abund mrnas activ modest translat select high express mrnas translate suppress abund moder abund mrnas mrnas associ specif monosom strong translat select low abund transcript involv metabol pathway lysosom found throughout bovin embryon develop notabl gene involv mitochondri function priorit translat found translat larg reflect transcript oocyt two cell embryo observ mark shift translat control eight cell embryo associ main phase embryon genom activ subsequ transcript translat becom synchron morula blastocyst taken togeth data reveal uniqu spatiotempor translat regul accompani bovin preimplant develop
D047108;D001755
T038;T042;T039;T018
36,227,580
intern sensori neuron regul stage specif growth drosophila anim control development schedul accord intern state extern environ drosophila larva well establish nutrient status sens differ intern organ turn regul product insulin like peptid therebi control growth contrast impact chemosensori system larval develop remain larg unclear perform genet screen identifi gustatori receptor gr neuron regul growth develop found gra express neuron requir proper progress larval growth gra express subset peripher intern sensori neuron direct extend axon insulin produc cell ipc central nervous system silenc gra express neuron block insulin like peptid releas ipc suppress larval growth mid larval period result indic gra express neuron promot larval develop direct regul growth promot endocrin signal stage specif manner
D004330;D029721
T123;T116;T204
36,227,576
transcript factor foxf foxf integr shh hgf tgf signal pathway drive tongu organogenesi tongu high special muscular organ divers cellular origin provid excel model understand mechan control tissu tissu interact organogenesi previous studi show shh signal requir tongu morphogenesi tongu muscl organ littl known under mechan demonstr foxffoxf transcript factor act cranial neural crest cell cncc deriv mandibular mesenchym control myoblast migrat tongu primordium tongu initi thereaft continu regul intrins tongu muscl assembl lingual tendon format perform chromatin immunoprecipit sequenc analysi identifi hgf tgfb tgfb among target gene foxf embryon tongu genet analys mice cncc specif inactiv smo foxf foxf show foxf foxf mediat hedgehog signal mediat regul myoblast migrat tongu initi intrins tongu muscl format regul activ hgf tgf signal pathway data uncov molecular network integr shh hgf tgf signal pathway regul tongu organogenesi
D053823;D018507
T045;T123;T116
36,227,525
physicochem antioxid properti industri hemp seed protein isol treat high intens ultrasound ultrasound one non thermal green novel technolog use function plant protein recent determin optimum condit high intens ultrasound hius treatment maximum solubl investig function properti hemp seed protein isol hspi optim condit studi analyz chang primari secondari tertiari structur physic microstructur thermal stabil antioxid capac ultrasound appli hemp protein isol hspi hius free sh group content zeta potenti increas upon ultrasound treatment electrophoret protein pattern hspi show signific chang hius treatment ftir spectrum reveal wavenumb shift amid region protein denatur temperatur ratio structur increas sonic antioxid properti hemp seed protein isol increas ultrasound treatment obtain data studi show hius treatment would promis improv function physicochem antioxid properti hspi
D000975;D002188
T002;T167;T121;T109;T123;T044;T039
36,227,509
accuraci intermitt scan continu glucos monitor system critic ill patient prospect multicent observ studi continu glucos monitor cgm potenti improv glucos control intens care unit icu set sought evalu accuraci intermitt scan cgm iscgm system critic ill patient
D016638;D003922
T047
36,227,508
interspeci differ clinic characterist risk factor third generat cephalosporin resist escherichia coli klebsiella pneumonia bloodstream infect patient liver cirrhosi retrospect studi aim clarifi interspeci differ clinic characterist risk factor bloodstream infect bsi due third generat cephalosporin resist gc r escherichia coli ec klebsiella pneumonia kp patient liver cirrhosi lc kp bsi comorbid higher treatment failur rate ec bsi non alcohol lc risk factor treatment failur ec wherea associ kp risk factor bsi due gc r strain nosocomi infect ec lactamfluoroquinolon treatment day kp result could help predict outcom bsi improv clinic practic
D007710;D016470;D004927;D018805
T047;T046
36,227,497
navig antiplatelet treatment option stroke evid base pragmat strategi benefit use antiplatelet monotherapi acut ischem stroke secondari stroke prevent well establish last year sever larg random trial show use short term dual antiplatelet therapi particular stroke subtyp may reduc risk recurr ischem event aim articl provid critic analysi current evid recommend use antiplatelet agent stroke prevent
D000083242;D020521
T047
36,227,451
mind base strategi improv sleep peopl psychiatr disord review recent literatur mind base strategi improv self report object measur sleep individu psychiatr disord
D064866;D019122;D007319
T047;T041;T184;T048
36,227,450
futur challeng psychotherapi research person disord individu person disord frequent seen mental health set symptom typic reflect high level suffer burden diseas potenti harm societ consequ includ cost relat absente work high use health servic ineffect harm parent substanc use suicid non suicid self harm behavior aggress legal consequ psychotherapi current first line treatment patient person disord studi psychotherapi domain person disord face specif challeng
D010554;D016728
T055;T048
36,227,449
role melatonin manag sleep circadian disord context psychiatr ill present review research role melatonin manag sleep circadian disord stress current overal view knowledg across psychiatr disord
D008550;D001714;D001289;D012893
T047;T121;T109;T048;T125
36,227,428
partial hydrolyz polyacrylamid enhanc oil recoveri applic oil field produc water pollut possibl solut polym partial hydrolyz polyacrylamid hpam wide use oil field enhanc improv recoveri crude oil reservoir work increas viscos inject water thus improv mobil oil recoveri howev enhanc oil recoveri eor oper also produc huge quantiti water alongsid oil depend age stage oil reserv oil field produc time water oil water contain various type toxic compon trace crude oil heavi metal differ type chemic use eor oper hpam thus huge quantiti hpam contain produc water generat worldwid requir proper treatment usag possibl toxic hpam still ambigu natur decomposit product acrylamid threaten human health ecolog environ therefor main challeng remov degrad hpam environment safe manner produc water proper dispos sever chemic thermal techniqu employ remov hpam environment friend somewhat expens among differ type treatment biodegrad aid individu mix microb biofilm tout effici environment friend way solv problem without harm side effect mani research explor report potenti bioremedi technolog variabl remov effici hpam oil field produc water lab scale field scale studi current review line unit nation sustain goal relat water secur unsdg highlight scale hpam base eor applic challeng produc water treatment current possibl solut futur possibl reus treat water sourc applic
D061329;D010578
T068;T109;T073;T070
36,227,425
spatial dynam veget model uptak diffus feedback arid environ veget pattern varieti structur amaz phenomena arid semi arid area identifi evolut law veget typic signal ecosystem function mani achiev made respect yet mechan uptak diffus feedback pattern structur veget fulli understood well reveal influenc paramet perturb pattern format veget give comprehens analysi veget water model form reaction diffus equat pose zelnik et al proc natl acad sci obtain exact paramet rang stationari pattern show dynam behavior near bifurc point base nonlinear analysi found model properti spot labyrinth gap pattern moreov water diffus rate prohibit growth veget shade paramet promot increas veget biomass result show gradual transit uniform state gap pattern occur suitabl valu paramet may induc emerg desertif
D003889;D017753
T082;T070
36,227,423
tempor optim radiat therapi heterogen tumour popul cancer stem cell extern beam radiat therapi key part modern cancer treatment use high dose radiat destroy tumour cell despit widespread usag extens studi theoret experiment clinic work mani question still remain best administ mani mathemat studi examin optim schedul radiotherapi come similar conclus import though studi general assum intratumor homogen recent year becom clear tumour homogen mass cancer cell wild heterogen mass various subpopul grow respond treatment differ one subpopul particular import cancer stem cell cscs known exhibit higher radioresist compar non cscs knowledg differ cell type could theoret lead chang optim treatment schedul studi examin question interest arriv appar conflict result howev understand assumpt reveal key differ lead differ conclus paper general problem tempor optim dose distribut radiat therapi two cell type model creat mathemat model numer optim algorithm find distribut dose lead optim cell kill creat data set optim solut use data analysi tool learn relationship model paramet qualit behaviour optim result analysi model discuss biolog import provid throughout find key factor predict behaviour optim distribut radiat ratio radiosensit present cell type result provid guidanc treatment case clinician knowledg tumour heterogen abund cscs
D009369
T191
36,227,422
local control brain metastas osimertinib alon patient egfr mutant non small cell lung cancer although osimertinib excel intracrani activ metastat non small cell lung cancer nsclc exon delet lr egfr alter measur local control brain metastas less well report describ lesion level outcom brain metastas treat osimertinib alon
D001932;D002289;D008175;D047428
T191;T116;T121
36,227,415
cost util analysi pegaspargas treatment acut lymphoblast leukemia greec acut lymphoblast leukemia acut rapid progress life threaten form cancer involv immatur lymphocyt call lymphoblast common subtyp leukemia children adolesc aim present studi assess cost util pegaspargas versus l asparaginas follow erwinas therapi sequenc treatment option pediatr adolesc adult patient greec
D001215;D054198
T121;T126;T116;T191
36,227,408
medic complex among older adult hf assess better medic manag heart failur hf evolv achiev signific surviv benefit result high complex medic regimen complex medic regimen creat challeng older adult includ nonadher increas advers drug event especi associ cognit impair physic limit lack social support howev associ medic complex patient health outcom among older adult hf unclear purpos review address complex hf medic assess literatur clinic outcom associ medic regimen complex hf aim explor older adult repres studi medic regimen complex index common use tool assess medic regimen complex rehospit frequent assess clinic outcom studi use medic adher qualiti life healthcar util healthcar cost side effect howev studi show inconsist result associ medic regimen complex clinic outcom also identifi extrem small number studi focus older adult notabl current medic regimen complex tool consid complic clinic condit older adult multimorbid therapeut competit drug interact alter toler usual dose strength medic furthermor outcom studi assess rare comprehens patient center studi requir fill knowledg gap identifi comprehens accur medic regimen complex tool patient center outcom assess
D006333;D064420
T047;T046;T037
36,227,407
still role transplant patient mantl cell lymphoma mcl era car cell therapi year upfront autolog hematopoiet cell transplant auto hct standard care younger physic fit mantl cell lymphoma mcl patient chemoimmunotherapi cit induct bruton tyrosin kinas btk inhibitor proven excel salvag therapi durabl remain question especi high risk hr mcl allogen hct allo hct option long term remiss possibl cure mcl relaps auto hct sometim upfront consolid young patient hr mcl debat seen paradigm shift sinc fda approv juli brexucabtagen autoleucel chimer antigen receptor car cell therapi relaps refractori rr mcl preliminari evid suggest car may overcom known biolog risk factor mcl given safeti profil excel efficaci role car among approv therapi hct may need better defin base current evid auto hct remain standard frontlin consolid therapi car therapi prefer option patient relapsedrefractori rr mcl particular fail btk inhibitor certain high risk mcl patient high ki tp alter complex karyotyp blastoid morpholog earli relaps initi diagnosi car cell therapi may consid btk inhibitor prefer clinic trial role allo hct unclear car era remain viabl option elig patient access fail car therapi review discuss current standard shift paradigm indic hct role car cell therapi mcl prospect studi tailor base risk factor need better defin optim sequenc hct cellular therapi approv novel therapi
D020522;D000076962;D018380
T047;T116;T192;T061;T191;T129
36,227,389
myco degrad microplast account identifi pathway analyt method determin microplast mps spark widespread concern due non degrad persist natur ecosystem long term exposur microplast caus chronic toxic includ impair reproduct malnutrit threaten biota human microplast also caus ingest choke entangl aquat popul thus crucial establish remark effect approach diminish mps environ regard use fungi microplast degrad benefici owe divers natur effect enzymat system extracellular intracellular enzym fungi degrad plastic polym monom produc carbon dioxid water aerob condit wherea methan anaerob condit fungi also secret hydrophobin surfac protein serv crucial aid bioremedi process promot substrat mobil bioavail therefor present review provid insight mechan general pathway fungal mediat microplast degrad addit analyt techniqu monitor mps degrad along roadblock futur perspect also discuss howev research requir fulli perceiv under process microplast biodegrad environ use fungus establish effect sustain practic manag
D000080545;D014874
T131;T122
36,227,381
accumul organochlorin pesticid ocp residu surfac water sediment znik lake turkey studi carri evalu organochlorin pesticid ocp concentr water column sediment znik lake water sampl sediment collect differ region six sampl site lake januari decemb test ocp gas chromatographi mass spectrometri gc ms result reveal ocp residu throughout site vari depend anthropogen activ region ocp detect surfac water rang gl sediment ngg dw endrin keton endrin aldehyd endosulfan ii endrin heptachlor epoxi beta bhc gamma bhc ppddd ppddt concentr exceed maximum residu limit indic world health organ surfac water analyz ocp compon detect sediment sampl note reach highest concentr summer presenc relat high ocp level accord regul water znik lake around agricultur activ increas rapid recent year serious concern therefor appropri action taken consider regulatori author
D006843;D010573;D010575;D014874
T109;T131
36,227,379
analysi particul pollut use urban aerosol pollut island intens delhi india accent present studi determin urban aerosol pollut island uapi intens spatial variabl particul matter concentr pm pm delhi analysi hour concentr dataset pm pm januari decemb obtain ten air qualiti monitor station delhi addit uapi index calcul assess intens particul pollut daili month annual variat trend pm pm uapi index along relat meteorolog paramet analyz particul pollut peak major two season ie summer winter highest concentr pm observ gm pm observ gm januari traffic affect region winter higher pm concentr observ ascrib increas local emiss enhanc secondari particl format increas pm concentr led increment pollut episod summer site delhi uapi index found declin traffic affect region respect well background region respect delhi low traffic intens reduc pollut emiss could respons reduct uapi intens year result indic lockdown implement control covid outbreak led unexpect decreas pm pollut delhi
D000393;D000397;D000086382
T047;T131;T069;T067;T080
36,227,378
dft studi therapeut potenti graphit carbon nitrid carrier control releas melphalan anticanc drug present research drug deliveri effici graphit carbon nitrid g cn melphalan anti cancer drug evalu investig efficaci g cn drug deliveri system electron properti melphalan drug g cn g cn melphalan calcul ground excit state adsorpt energi calcul g cn melphalan complex water phase ev interact g cn melphalan investig non coval interact ncl analysi show weak interact g cn melphalan drug low intermolecular forc allow easi load melphalan target site frontier molecular orbit fmos analysi show charg transfer melphalan g cn excit process charg transfer studi charg decomposit analysi calcul excit state reveal g cn melphalan complex max show redshift nm nm gas water phase respect photoinduc electron transfer pet process studi excit state use electron hole theori pet process suggest fluoresc quench may take place find demonstr g cn use drug deliveri system melphalan drug treat cancer investig may also encourag consider differ substanc drug deliveri
D000970;D008558
T121;T109;T116
36,227,373
impact vari dose moringa leaf methanol extract supplement cryopreserv media sperm qualiti oxid antioxid capac frozen thaw ram sperm increas ram post thaw semen qualiti follow cryopreserv studi use enrich tris base diluent vari amount moringa leaf methanol extract mlme antioxid activ total phenol total flavonoid content assess mlme sperm five healthi awassi ram collect divid equal aliquot dilut vv tris citrat glucos extend supplement mg mlmeml without mlme supplement control percentag sperm total motil stm sperm progress motil spm viabil v abnorm morpholog membran function integr mfi acrosom integr ai measur malondialdehyd mda nitric oxid ascorb acid aa superoxid dismutas sod glutathion peroxidas gpx total cholesterol tc low densiti lipoprotein ldl lactat dehydrogenas ldh alkalin phosphatas alp zinc zn copper cu measur total phenol gallic acid flavonoid catechin equival content mgg mgg respect diphenyl picrylhydrazyl mm teg azino bis ethylbenzothiazolin sulfon acid mm teg found mlme mlme mm teg ferric reduc power comparison control addit mgml mlme tris base extend result highest p stm spm sv mfi ai lowest p valu comparison control addit mgml semen extend result lower stm spm sv mfi ai higher percentag mda p p cho p ldl p reduc mgml mlme aa p sod p elev conclus highest copper p lowest zinc concentr mlme mgml extend deterior post thaw semen qualiti prompt us suggest addit mg mlme ram tris base semen extend
D002392;D029587;D012662
T002;T059;T058;T121;T109;T031
36,227,369
biomolecul serratia sp cs indigen ethiopian natur alkalin lake biosurfact characterist assess compat laundri deterg studi biosurfact bio sfs produc bacteria screen select alkalin lake ethiopia potenti bacteri strain produc bio sfs character initi screen bacteri isol isol among bacteri isol assign cs identifi potent produc bio sfs use subsequ character process cs strain identifi serratia sp via biochem molecular method emuls index e obtain cs day incub time c cs extract bio sfs character fourier transform infrar ftir indic type biosurfact produc glycolipid stabil crude bio sfs character optim condit found c ph nacl respect extract bio sfs compat test commerci deterg effici increas combin commerci avail deterg brand ethiopia taza largo respect studi suggest isol marcescen cs strain potenti produc bio sfs viabl compet replac use synthet chemic product commerci deterg
D003902;D013501
T121;T073;T120;T122
36,227,368
minoca myocardi infarct nonobstruct coronari arteri myocardi infarct nonobstruct coronari arteri minoca account present acut myocardi infarct
D000088442;D009203
T047
36,227,364
inhibit cytochrom p enhanc nephro hepatotox ochratoxin mycotoxin ochratoxin ota contamin food caus nephrotox minor degre hepatotox recent observ ota induc liver damag preferenti cytochrom p cyp express pericentr lobular zone similar hepatotox substanc known metabol toxifi cyp acetaminophen carbon tetrachlorid investig whether cyp influenc ota toxic use singl dose ota mgkg intraven without pre treatment pan cyp inhibitor aminobenzotriazol abt h ota administr blood urin well liver kidney tissu sampl collect h ota administr biochem histopatholog analys inhibit cyp abt strong increas nephro hepatotox ota urinari kidney damag biomark kidney injuri molecul kim neutrophil gelatinas associ lipocalin ngal increas fold fold respect mice treat abt ota compar receiv ota alon blood biomark liver damag alanin transaminas alt aspart transaminas ast increas fold respect ota administ abt pre treat mice compar effect ota alon histolog analysi liver reveal pericentr lobular damag induc ota despit cyp inhibit abt administr abt alon caus hepato nephrotox overal result present compat scenario cyp mediat detoxif ota yet mechan respons pericent liver damag pattern still remain elucid
D009183;D008107;D056486
T047;T037;T131;T109;T033
36,227,352
cannabi contain equival concentr delta tetrahydrocannabinol thc cannabidiol cbd induc less state anxieti thc domin cannabi delta tetrahydrocannabinol thc activ compon cannabi caus anxieti user intox cannabidiol cbd anoth constitu cannabi anxiolyt properti suggest cannabi product contain cbd addit thc may produc less anxieti thc product find date around issu inconclus could conceiv depend moder factor baselin anxieti level user
D002185;D002188;D014151;D006213
T002;T167;T131;T121;T109;T039
36,227,346
salivari gland tumor overview advanc molecular character part recent year character salivari gland tumor undergon major transform morpholog defin entiti could larg extent also character molecular often distinct genotyp first part articl review advanc molecular characterist mucoepidermoid carcinoma adenoid cystic carcinoma acin cell carcinoma secretori carcinoma intraduct carcinoma hyalin clear cell carcinoma molecular genotyp particular use classifi unusu morpholog variant recurr ntrk ret gene fusion use diagnost tool also potenti target therapi
D012468;D018277;D003528;D018267;D002285
T191
36,227,345
new treatment option metastat low breast cancer consequ histopatholog diagnosi overexpress breast cancer classic exampl molecular target therapi shown classic anti therapeut effect patient overexpress tumor therefor recent decad pathologist focus reliabl identif overexpress tumor base result recent clinic trial metastat breast cancer antibodi drug conjug adc diagnost strategi evalu current chang shown adc trastuzumab deruxtecan effect tumor classic overexpress also low tumor clinic trial result lead paradigm shift treatment patient whose tumour previous classifi negat addit identif score overexpress tumor necessari identifi low express tumor defin immunohistochemistri ihc score ihc negat situ hybrid due therapeut consequ import quick adapt diagnost workup report new requir addit new therapeut option anti therapi lead new challeng standard well new scientif question character tumor low express
D001943
T191
36,227,344
tempo control resist train hip abductor ankl dorsiflexor light load improv postur sway older adult forc steadi capabl hip abductor ankl dorsiflexor explain signific amount varianc postur sway four type stand balanc test control balanc well forc steadi general worsen age although latter improv uniqu train intervent purpos studi assess tempo control light load resist train hip abductor ankl dorsiflexor influenc perform clinic movement test postur sway muscl strength forc steadi older adult particip n year men complet nine train session either hip abductor ankl dorsiflexor nondomin leg train involv lift load equal maxim forc achiev isometr contract linear mix effect model reveal chang p sit stand test time go test maxim voluntari contract mvc torqu postur sway either train intervent dorsiflexor group signific improv nondomin leg dorsiflexion forc steadi translat task howev absolut relat measur mvc torqu forc steadi hip abductor ankl dorsiflexor domin nondomin leg could predict sway area rate four stand balanc condit respons leg muscl light load steadi train older adult appear depend type exercis perform intervent
D055070
T061
36,227,343
efficaci corsi block tap task train improv visuospati skill non random two group studi even though impair visuospati abil negat affect daili function train program attempt improv visuospati abil purpos studi examin singl train session computer version corsi block tap task could improv mental rotat skill fifti three young adult assign one two group control group mean age femal min rest baselin assess train group mean age femal min train corsi block tap task baselin assess primari outcom reaction time comput base mental rotat task assess rest train signific interact time pre vs post group control vs train mental rotat perform p train group perform averag ms faster accur trial control group post test preliminari studi suggest improv mental rotat may feasibl target cognit train futur studi consid multipl session corsi block tap task train maxim train benefit ie dose respons well longer term retent cognit intact impair individu
D003072;D065854
T041;T048
36,227,342
slow reaction time cognit fatigu attribut declin motor prepar cognit fatigu cf result sustain mental effort character subject feel exhaust cognit perform deficit associ slow simpl reaction time rt studi determin whether declin motor prepar underli rt effect motor prepar level index use simpl rt startreact effect wherein prepar movement involuntarili trigger short latenc startl acoust stimulus sas predict decreas motor prepar under cf associ rt increas attenu startreact effect would observ follow cognit task complet subject fatigu assess simpl rt task perform cognit fatigu task non fatigu control intervent rt trial sas replac go signal assess startreact effect cf induc verifi signific declin cognit perform p along increas subject cf p control rt p follow cognit fatigu intervent control intervent signific pre post test chang sas rt observ indic rt increas result cf substanti associ declin motor prepar instead may attribut stage process simpl rt task
D013216;D009068
T040;T039
36,227,337
psychosoci care relat icu framework concept famili center care import aspect care intens care medicin current agreement implement intens care unit icus specif concept palliat medicin pediatr offer good basi content adapt field intens care medicin icus formul implement minimum standard base goal share decis make support relat accompani patient support potenti burden relat relat protocol report evalu develop staff train famili center care liabil provis great relev implement
D000067250
T061;T058
36,227,321
crimin legal involv among recent separ veteran find limbic studi studi investig individu level neighborhood level predictor crimin legal involv veteran critic transit period militari civilian life
D057237;D008889;D019966;D014728
T098;T097;T048;T033
36,227,320
whose perspect differ actor observ determin voluntari guilti plea valid guilti plea must made voluntarili yet defend report feel part decis make process respons decis defend judg play role determin whether guilti plea voluntari actor observ bias suggest defend judg perceiv decis make process differ given natur role present studi appli framework assess complex voluntari plea decis make
D057237;D006167
T098;T041
36,227,319
guilti plea hear juvenil crimin court guilti plea hear judg must determin whether defend plea decis made know intellig voluntarili littl known howev plea hear unfold especi juvenil court hear general close public studi uniqu opportun systemat observ plea hear juvenil crimin court
D057237
T098
36,227,295
inhibitori role microrna kidney stone format repress calcium oxal crystal via vdrfoxo regul axi kidney stone regard common malign diseas develop world result signific research examin format ongo microrna mir recent link kidney stone format aim defin potenti role mir regul renal tubular epitheli cell rtec viabil attach calcium oxal caox crystal rtec via vitamin receptor vdr forkhead box protein foxo axi patholog condit caox crystal induc examin spragu dawley rat rtec isol cultur vitro loss gain function assay perform studi effect mir vdr foxo rtec function caox crystal vitro kidney stone format vivo interact mir vdr confirm dual luciferas report gene assay downregul mir foxo well overexpress vdr identifi kidney stone model rat vdr confirm target gene mir knockdown vdr upregul foxo express mir overexpress vdr suppress reduc rtec cytotox crystal attach rtec vitro reduc caox crystal vivo taken togeth find suggest mir overexpress may potenti inhibitor rtec prolifer caox crystal vdrfoxo regulatori axi provid novel therapeut target treatment kidney stone
D007669;D035683
T047;T123;T114
36,227,280
advanc bioactiv hydrogel treatment myocardi infarct myocardi infarct mi lead caus cardiovascular diseas relat death local ischemia cardiomyocyt death lead seri patholog remodel event infarct extracellular matrix ecm signific differ normal cardiac tissu patholog characterist inspir develop microenviron respons therapeut strategi mi bioactiv hydrogel attract great attent uniqu physicochem featur induc specif biolog respons upon interact cell ecm signal molecul exhibit physicochem respons activ regul interact hydrogel biolog system mani bioactiv hydrogel intellig properti use repair infarct myocardium restor cardiac function mi current research studi ensur bioactiv hydrogel high clinic import applic prospect review summar advanc bioactiv hydrogel field demand treatment mi evalu key physicochem characterist rang bioactiv hydrogel biomed applic discuss repair injur heart restor cardiac function provid insight develop intellig therapeut approach mi
D020100;D009203
T047;T122
36,227,277
infrar thoracoscop extend lobectomi right upper lobe intraven indocyanin green administr use preoper simul ensur safe surgic margin although crucial ensur suffici surgic margin malign neoplasm sometim struggl achiev goal use minim invas approach difficult palpat tumor adequ via small skin incis overcom issu adopt preoper simul method patient undergo right upper lobe posterior segmentectomi lower lobe extend lobectomi obtain success result discrep virtual actual surgic margin mm
D002289;D008175
T191
36,227,261
hitchhik posit endoscop pituitari surgeri technic ergonom correct posit essenti endoscop transsphenoid pituitari surgeri
D010911
T191
36,227,256
unilater approach posterior spinal canal decompress cervic spondylot myelopathi evalu conceptu feasibl patient cervic spondylot myelopathi csm treat posterior approach spinal canal decompress
D013118;D013130
T047;T020
36,227,253
fractur lumbar drain cathet retriev use endoscop transforamin approach lumbar spine lumbar drain placement common neurosurg procedur sever surgic medic indic extend even beyond specialti one complic placement fractur cathet fragment circumst cathet retriev necessari classic perform open approach present report case retain lumbar drain cathet retriev use transforamin endoscop approach lumbar spine
D004724;D008159
T023;T060
36,227,252
technic assess microvascular decompress trigemin neuralgia use dimension exoscop case seri detail anatom visual root entri zone trigemin nerv crucial success perform microvascular decompress surgeri mvd patient trigemin neuralgia
D061145;D014277
T061;T047
36,227,251
nerv transfer elbow reconstruct upper extend upper type brachial plexus injuri case seri nerv transfer elbow flexion brachial plexus injuri use increas frequenc higher rate success accept morbid especi true upper extend upper type brachial plexus injuri
D001917;D004551;D016067
T061;T023;T030
36,227,250
synthesi comput investig biolog evalu difluoromethyl keton embodi pyrazol isoxazol nuclei cox inhibitor difluoromethyl keton dfmks emerg current investig agent benefit merg chemico physic featur confer constitut element chf carbonyl moietit view biolog applic addit incorpor heterocycl desir properti enabl tune critic factor encompass pharmaco dynam kinet profil underexplor assembl difluoromethyl heteroaromat keton herein implement via conceptu intuit weinreb amid acyl transfer putat difluoromethyl carbanion make strategi product adopt commerci avail tmschf pronucleophil character robust chemic stabil manipul bp c upon lewi base mediat activ deliv compet chf nucleophil synthet protocol carri pyrazol isoxazol base scaffold panel heteroaryl dfmks consequ develop potenti cox inhibitor sens bioisoster deduct dock studi wide express carboxyl group sever clinic use cox inhibitor cochf motif introduc herein support rational confirm dock result compound test cox cox enzym isoform show activ micromolar rang good select index si also evalu biocompat use niht cell show signific toxic
D007659;D007555
T109
36,227,244
use cannul reamer facilit thorac diskectomi use minim invas retropleur thoracotomi approach surgic techniqu surgic treatment symptomat thorac disk herniat technic challeng past decad minim invas retropleur thoracotomi approach becom popular treat patholog howev effici bone remov safe perform diskectomi spinal cord decompress difficult techniqu small incis size long work distanc thorac caviti proxim compress thorac cord
D007405;D013908
T061;T047
36,227,242
prone transpsoa later lumbar interbodi fusion degen lumbar spine diseas case seri oper video use fluoroscopi base instrument track guidanc later lumbar interbodi fusion inher limit necess reposit patient overcom limit prone transpsoa ptp approach later lumbar interbodi fusion develop
D008141;D013123
T061;T047
36,227,241
transient prenyltransferas cyclas associ fusicoccadien synthas assembl line terpen synthas fusicoccadien synthas fungus phomopsi amygdali paf assembl line terpen synthas catalyz first two step biosynthesi fusiccocin diterpen glycosid c termin prenyltransferas domain paf catalyz condens one molecul c dimethylallyl diphosph three molecul c isopentenyl diphosph form c geranylgeranyl diphosph transit cyclas domain cyclize form fusicoccadien previous structur studi paf use electron microscopi em reveal central octamer prenyltransferas core eight cyclas domain tether random distal posit flexibl residu linker howev proxim prenyltransferas cyclas configur could captur coval cross link observ cryo em mass spectrometri use cryo em show proxim configur prenyltransferas cyclas complex observ even absenc coval cross link moreov complex involv multipl cyclas domain conserv basic patch prenyltransferas domain compris primari touchpoint cyclas domain result support model transient prenyltransferas cyclas associ cyclas domain paf facil equilibrium proxim associ random distal posit relat central prenyltransferas octam result biophys measur use small angl x ray scatter analyt ultracentrifug dynam light scatter size exclus chromatographi line multi angl light scatter consist model model accord provid framework understand substrat transit prenyltransferas cyclas domain well cooper observ geranylgeranyl diphosph cyclize
D004122;D019883;D004224
T109;T126;T116
36,227,239
ten step dimension navig singl stage later surgeri microtubular decompress case seri singl stage later lumbar interbodi fusion safe effect procedur reli indirect decompress fusion treat various lumbar patholog techniqu howev overal rate indirect decompress failur may requir addit surgeri achiev adequ direct decompress address concern modifi techniqu ad minim invas direct tubular decompress later posit indic studi describ technic nuanc incorpor microtubular decompress singl stage later lumbar interbodi fusion workflow ssllif
D008159;D013123
T061;T023
36,227,230
use antibacteri envelop prevent infect neuromodul implant puls generat neuromodul unit placement carri histor infect rate high treatment requir surgic remov long cours system antibiot antibiot impregn envelop effect prevent infect implant cardiac devic center surgeon use envelop implant neuromodul unit
D000900;D019736
T121;T074;T195
36,227,229
three dimension model augment realiti virtual realiti simul fiber dissect cerebellum brainstem surgeon must understand complex anatomi cerebellum brainstem dimension relationship surgeri success best knowledg fiber dissect studi combin model augment realiti ar virtual realiti vr structur cerebellum brainstem studi creat freeli access ar vr simul model cerebellum brainstem
D000081411;D000076142
T170;T066
36,227,228
efgartigimod general myasthenia gravi without anti acetylcholin receptor antibodi worldwid japanes perspect manag myasthenia gravi mg improv due immunotherapi advanc individu mg refractori convent therapi need novel biolog drug remain
D001688;D009157
T121;T047;T123
36,227,227
diaphragmat hernia incarcer spleen complic later anterior column realign creation sagitt balanc spine critic treatment adult spinal deform anterior column releas acr gain traction minim invas altern pedicl subtract osteotomi releas anterior longitudin ligament anterior column lengthen physiolog lordosi restor risk transient psoa weak thigh numb well document literatur howev diaphragmat hernia never report
D006548;D013123
T061;T047
36,227,224
contactless ultrason cavit prevent shunt obstruct hydrocephalus proof concept studi obstruct failur implant shunt common complic treatment hydrocephalus biolog materi debri accumul inner wall valv cathet block normal flow drain cerebrospin fluid caus sever symptom high morbid mortal unfortun present effect prevent protocol clean procedur avail
D006108;D006849
T047;T019;T109;T196;T033
36,227,218
explor volatil organ compound emiss thermal modifi wood ptr tof ms thermal modif wood well known industri process perform increas durabl dimension stabil chang colour natur wood treatment influenc mani properti wood includ emiss volatil organ compound voc voc releas ultim affect qualiti indoor air capabl low voc emiss often includ key paramet attribut qualiti label present work wood six tree speci subject differ type treatment voc profil carri treat untreat sampl mean ptr tof ms differ type thermal treatment test involv either overpressur vacuum effect differ temperatur profil evalu hardwood softwood show differ releas profil test condit headspac softwood richer sever voc terpen phenol c c aldehyd carboxyl acid upon thermal treatment terpen emiss decreas wherea sever voc formic acid formaldehyd furfur acet acid releas higher amount high sensit throughput ptr tof ms appear power analyt tool use support select wood materi differ end use
D055549
T109
36,227,197
explor impact surfac act nurs leader covid coronavirus covid massiv impact health system mani nation includ australia nurs leader part leadership manag role manag emot respons peopl around nurs leader purpos studi explor experi nurs leader held manag role health servic crisi result covid pandem look emot work nurs leader engag impact emot work nurs leader emot well
D000086382
T047;T067
36,227,194
three dimension model augment virtual realiti simul white matter anatomi cerebrum understand anatomi white matter tract dimension relationship import neurosurg practic fiber dissect techniqu contribut understand involv remov brain white matter tract reveal anatom organ use techniqu built freeli access model augment virtual realiti simul white matter tract
D054022;D000076142;D066127
T023;T024;T066
36,227,174
cultur respons telepsycholog mhealth intervent racial ethnic minorit youth research gap futur direct telepsycholog mhealth tpmh servic youth famili becom increas preval recent year howev signific limit theori research polici introduc question effect intervent particular racial ethnic minorit youth famili alreadi contend inequ mental health treatment access outcom although tpmh potenti reduc barrier mental health servic way may benefit racial ethnic minorit youth famili mental health field must first grappl limit cultur respons tpmh work avoid perpetu exist mental health inequ articl begin briefli review extant literatur tpmh youth cultur adapt cultur respons evid base intervent racial ethnic minorit youth famili intersect tpmh cultur respons intervent inform gap identifi review provid recommend futur direct cultur respons tpmh racial ethnic minorit youth famili recommend organ four overarch categori conceptu theoret recommend research prioriti practic polici recommend engag access recommend recommend offer novel idea research clinician fund agenc polici maker key stakehold intend facilit equiti tpmh racial ethnic minorit youth famili
D008605;D017216
T058
36,227,173
palmit acid inhibit vascular smooth muscl cell switch synthet phenotyp via upregul mir express synthet phenotyp switch vascular smooth muscl cell vsmcs shown play key role vascular diseas mount evid shown fatti acid metabol high associ vascular diseas howev fatti acid regul vsmc phenotyp poor understood henc effect palmit acid pa vsmc phenotyp determin studi effect pa vsmcs measur livedead edu assay well flow cytometri migrat abil vsmcs evalu use transwel assay under target mir predict use bioinformat onlin tool confirm luciferas report assay rna protein express certain gene detect qrt pcr western blot pa inhibit vsmc switch synthet phenotyp manifest inhibit vsmc prolifer migrat synthesi pa upregul mir vsmcs mir mimic exert similar effect pa treatment inhibit vsmc switch synthet phenotyp inhibit mir use mir inhibitor block impact pa vsmc phenotyp modul suggest pa modul vsmc phenotyp upregul mir express found ecotrop virus integr site protein homolog evi target mir regul vsmc phenotyp overexpress mir orand pa treatment attenu inhibit evi switch vsmcs find suggest pa inhibit vsmc switch synthet phenotyp upregul mir therebi inhibit evi correct dysregul mir evi pa metabol potenti treatment vascular diseas
D035683;D014652
T047;T123;T114
36,227,172
quantif mechan stimuli induc nucleoplasm transloc yap distribut mechan use afm dstorm coupl techniqu cell regul varieti behavior sens mechan signal includ growth differenti apoptosi yes associ protein yap mechan sensit protein use indic mechanosign transduct unlik macroscop statist analysi singl cell analysi demand challeng term mechanist regul quantifi locat amplitud durat singl cell mechan stimul precis mechan modul simultan observ mechan forc induc yap nuclear cytoplasm distribut transloc use afm dstorm coupl techniqu addit investig regul yap transloc accord physic factor cytoskelet destruct osmot pressur biochem factor nuclear activ transport protein inhibit starvat studi reveal mechan signal transfer cytoskeleton nucleus synergist action microfila microtubul induc yap transloc nucleus cytoplasm cooper nuclear export protein conclus deepen understand signal pathway mechan signal transmit plasma membran cytoplasm nucleus determin cell fate
D048868;D014157
T123;T116
36,227,169
modul motor unit discharg relat chang fascicl length isometr contract integr electromyographi emg ultrasound imag provid import inform mechan muscl activ contract unfortun convent bipolar emg allow accur assess interplay neural drive receiv muscl chang fascicl length torqu aim assess relationship modul tibiali anterior muscl ta motor unit mu discharg fascicl length dorsiflexion torqu use ultrasound transpar high densiti emg electrod emg ultrasound imag record simultan ta use electrod silicon matrix perform isometr dorsiflexion contract two ankl joint posit plantar flexion torqu maximum emg signal decompos mus chang fascicl length assess fascicl track algorithm mu fire convert cumul spike train cst cross correl torqu cst torqu fascicl length cst length high cross correl found cst length rang cst torqu rang cross correl delay reveal delay cst fascicl length ms smaller cst torqu ms p lt delay affect mu recruit de recruit threshold sinc fascicl length mus recruit de recruit similar mu recruit de recruit torqu vari studi demonstr chang ta fascicl length relat modul mu fire dorsiflexion torqu relationship allow assess interplay neural drive muscl contract torqu enabl time requir convert neural activ movement quantifiednew amp noteworthi employ ultrasound transpar high densiti emg electrod show modul tibiali anterior muscl motor unit discharg rate relat chang fascicl length result torqu relationship permit quantif relat delay fluctuat neural drive muscl contract transfer torqu via tendon sustain isometr dorsiflexion contract provid inform convers neural activ muscl forc contract
D007537;D010351
T058;T042
36,227,167
inspiratori leg muscl blood flow inspiratori muscl metaboreflex activ heart failur preserv eject fraction purpos studi determin cardiovascular consequ elicit activ inspiratori muscl metaboreflex patient heart failur preserv eject fraction hfpef control patient hfpef n yr kgm control n yr kgm perform inspiratori load trial maxim inspiratori pressur pimax task failur mean arteri pressur map measur continu near infrar spectroscopi bolus inject indocyanin green dye use determin percent chang blood flow index bfi baselin final minut inspiratori load vastus laterali sternocleidomastoid muscl vascular resist index vri calcul time task failur shorter hfpef control vs p compar control patient hfpef greater increas baselin map vs mmhg vastus laterali vri vs well greater decreas vastus laterali bfi vs p lt sternocleidomastoid bfi normal absolut inspiratori pressur higher hfpef compar control vs per cmhos p data indic patient hfpef exhibit exagger cardiovascular respons inspiratori muscl metaboreflex activ compar controlsnew amp noteworthi respiratori muscl dysfunct thought contribut exercis intoler heart failur preserv eject fraction hfpef howev under mechan unknown present studi patient hfpef greater increas leg muscl vascular resist index greater decreas leg muscl blood flow index compar control inspiratori resist breath activ metaboreflex furthermor respiratori muscl blood flow index respons normal pressur generat inspiratori resist breath exagger hfpef compar control
D007866;D006333
T023;T046;T047
36,227,166
role nitric oxid flow induc myogen respons branch porcin middl cerebr arteri myogen flow induc reactiv contribut cerebr autoregul potenti diverg role smaller versus larger arteri present studi test hypothes compar first order branch middl cerebr arteri second third order branch respect exhibit greater myogen reactiv reduc flow induc constrict furthermor nitric oxid synthas nos inhibit may amplifi myogen reactiv abolish instanc flow induc dilat isol porcin cerebr arteri mount pressur myograph expos increment increas intralumin pressur mmhg n flow lmin n intralumin flow adjust achiev dyncm wall shear stress mmhg myogen tone greater versus arteri p invers relationship myogen reactiv passiv arteri diamet p nos inhibit increas basal tone lesser extent versus arteri p influenc myogen reactiv p increas flow decreas lumin diamet p increas vasoconstrict dyncm shear stress p howev relat respons similar arteri p without nos inhibit condit p wherea nos inhibit increas basal myogen tone myogen reactiv less smaller versus larger arteri rang neither nos inhibit lumin diamet influenc flow induc constrict porcin cerebr arteri new noteworthi studi demonstr size depend heterogen myogen reactiv porcin cerebr arteri smaller branch middl cerebr arteri exhibit increas myogen reactiv attenu nos depend increas myogen tone compar larger branch flow depend regul exhibit variat diamet independ flow induc vasoconstrict occur across branch order affect nos inhibit conceptu flow induc vasoconstrict contribut cerebr autoregul particular larger arteri low myogen tone
D009569;D020768
T121;T023;T197
36,227,165
metformin attenu increas calcium depend ubiquitin proteasom marker unload muscl current studi test hypothesi skelet muscl unload calcium depend signal pathway marker protein synthesi express e ubiquitin ligas regul metformin thirti two male wistar rat random assign one four group nontreat control c control rat treat metformin cm day unloadinghindlimb suspens placebo hs day unload treat metformin hsm soleus muscl hs group level phospho amp activ protein kinas p ampk decreas atp content increas compar control group increas level phospho camk ii upregul calcineurin sercaa calpain mrna express respect p lt hs group relat control hs group also increas mrna express murf mafbx ubiquitin respect p lt compar control soleus muscl metformin treatment imped unload induc chang soleus muscl conclus metformin treatment day soleus muscl unload prevent decreas p ampk increas atp content affect regul calcium depend signal pathway via level camk ii phosphoryl camk ii sercaa calpain mrna express attenu increas express critic marker ubiquitin proteasom pathway murf mafbx ubiquitin affect unload induc increas ulk marker autophagiclysosom pathwaynew amp noteworthi current studi first time test hypothesi day soleus muscl unload calcium depend signal pathway marker protein synthesi express e ubiquitin ligas regul metformin treatment metformin unload prevent decreas p ampk increas atp content affect regul calcium depend signal pathway attenu increas critic marker ubiquitin proteasom pathway nevertheless metformin treatment prevent soleus muscl atrophi
D025801;D008687
T121;T109;T123;T116
36,227,159
select cell activ pbrm bromodomain inhibitor discov nmr fragment screen pbrm subunit pbaf chromatin remodel complex uniqu contain six bromodomain pbrm oper tumor suppressor tumor promot pbrm tumor promot prostat cancer contribut migratori immunosuppress phenotyp select chemic probe target pbrm bromodomain desir elucid associ aberr pbrm chromatin bind cancer pathogenesi contribut pbrm immunotherapi previous pbrm inhibitor unselect bind smarca smarca bromodomain nanomolar potenc use protein detect nmr screen pipelin screen fragment second pbrm bromodomain identifi hit k valu mm structur activ relationship studi tightest bind hit result nanomolar inhibitor select pbrm smarca smarca chemic probe inhibit associ full length pbrm acetyl histon peptid select inhibit growth pbrm depend prostat cancer cell line
D006657;D011471
T191;T123;T116
36,227,155
parallel dna circuit autocatalyt strand displac nanopor readout dna nanotechnolog provid uniqu opportun molecular comput strand displac reaction enabl control reorgan nanostructur addit dna strand exchang strategi high select input enabl novel complex system includ biosens applic herein propos autocatalyt strand displac acsd circuit initi dna breath acceler seesaw catalyt reaction acsd ensur correct base sequenc start catalyt cycl analog electron circuit variabl resistor two acsd reaction differ rate connect parallel mimic parallel circuit contain branch differ resist final introduc multiplex nanopor sens platform report output result parallel path select system singl molecul level combin acsd strategi fast sensit singl molecul nanopor readout new generat dna base comput tool establish
D058608
T082
36,227,154
novel small molecular compound jy obz allevi ad patholog cell model via regul multipl target alzheim diseas ad common form neurodegen dementia character cognit deficit memori dysfunct clinic incur far novel small molecular compound jy obz one structur analogu huperzin hup anti ad drug china previous work jy obz exhibit potent effect tau hyperphosphoryl product acetylcholinesteras ach activ howev jy obz anti ad effect under molecular mechan remain unclear report jy obz resist tau hyperphosphoryl thr ser site hek htau cell transfect gsk decreas tau phosphoryl via upregul activ ppa hek htau cell reduc product regul protein level app cleavag enzym na happ cell meanwhil found jy obz advers effect cell viabil mice primari neuron even high concentr amelior synapt loss induc human oligomer jy obz moder ach inhibitori activ half maxim inhibitori concentr ic gml vitro two time higher hup togeth jy obz show promis therapeut effect ad cell model regul multipl target research provid new candid therapeut develop ad
D000544
T047;T048
36,227,152
polaris human macrophag toward subtyp trigger atyp brazilian strain toxoplasma gondii result reduct parasit burden toxoplasma gondii nicoll et manceaux etiolog agent toxoplasmosi consid clonal popul three distinct genet lineag ii iii howev sequenc analysi differ strain reveal distinct atyp genotyp macrophag essenti immun toxoplasmosi differenti cell regul may affect cours diseas context studi aim investig infect tgchbrud high virul atyp brazilian strain gondii activ polaris human macrophag human macrophag like cell obtain thp cell infect tgchbrud rh strain gondii evalu impact parasit infect macrophag polaris result indic tgchbrud strain gondii induc classic activ human macrophag confirm high rate spindl shape macrophag low amount urea increas level nitrit well regul marker contrast rh strain promot altern activ macrophag polaris human macrophag toward subtyp mediat tgchbrud strain result low parasit burden high level il mif final subtyp trigger rh strain culmin lower intracellular prolifer index conclud atyp tgchbrud clonal strain abl elicit subtyp result parasit control partial explain high level il mif produc infect genotyp contrast clonal rh strain promot macrophag polaris toward subtyp mark high parasit burden weak modul pro inflammatori cytokin thus atyp strain present differ mechan pathogen transmiss compar clonal strain well use distinct strategi evad host immun respons ensur surviv
D010271;D014122;D014123
T047;T204
36,227,151
noncod rnas mediat overexpress kif associ tumor immun infiltr unfavor prognosi lung adenocarcinoma kinesin famili member kif potenti oncogen act chromokinesin via bind microtubul chromatin bipolar spindl format kif overexpress signific prognost biomark various cancer howev express prognosi mechan tumor immun regul kif lung adenocarcinoma luad remain obscur result demonstr kif upregul varieti cancer includ luad high express kif luad associ patholog tumor stage n stage unfavor prognosi univari multivari cox regress result demonstr kif signific independ risk factor influenc prognosi luad patient promis upstream ncrna associ pathway kif luad determin gsectymso hsa mir p axi accord starbas cancer genom atlas databas furthermor upregul kif luad posit correl tumor mutat burden microsatellit instabl immun checkpoint relat gene express immun cell biomark tumor immun cell infiltr studi reveal ncrnas mediat overexpress kif associ tumor immun infiltr unfavor prognosi luad
D008175;D000077192
T191
36,227,148
age associ chang microglia activ sirtuin chromatin bind pattern age process associ chang mechan maintain physiolog influenc genet lifestyl impact late life qualiti longev brain health critic healthi age sirtuin sirt histon deacetylas silenc properti one molecular determin experiment link health longev compar brain pathogenesi sirt chromatin bind dynam brain pre frontal cortex group elder rhesus macaqu divid age necropsi shorter live anim year old yo equival human yo longer live anim yo correspond human yo model success age compar young adult brain yo find indic drastic differ microglia marker iba along factor influenc sirt level activ cd enzym limit nad control sirt activ mir microrna target sirt transcript elder group iba lower shorter live anim group cd higher age group compar young mir sirt level invers correl longer live brain yo shorter live brain yo also found sirt bind show sign better effici longer live anim compar shorter live one gene associ nuclear activ senesc overal differ neuroinflamm sirt interact chromatin distinguish shorter longer live anim suggest import preserv microglia sirt function effici longev
D017628;D056564
T025;T126;T116
36,227,146
make case adult orthodont clear align therapi provid general dentist today digit world consum abl complet everi task groceri shop bank comfort bed strong emphasi place conveni simplic dental patient want healthi function esthet pleas teeth smile clear align util relat expedi manner creat optim condit overal dental well exist digit workflow clinician abl provid patient healthi esthet dentit easili past case present report demonstr use orafit clear align correct simpl malocclus help provid patient smile desir
D008310;D009968;D009970
T074;T078;T091;T190;T033
36,227,144
presidenti elect prenat care util among foreign born hispan pregnant peopl studi evalu relationship adequ time prenat care among immigr pregnant peopl recent polit climat includ elect associ campaign
D006630;D011295
T098;T058
36,227,142
sex differ associ patholog albuminuria subclin atherosclerosi insight lan longitudin age studi patholog albuminuria pau urinari albumin creatinin ratio uacr mgg independ risk factor cardiovascular diseas pau preval men women aim compar associ pau earli phase subclin atherosclerosi sa sex
D000419;D050197
T047;T046;T033
36,227,138
high fhl mrna express prognost valu lung cancer lung cancer frequent cancer global high number cancer relat death half lim domain protein fhl oncogen gene promot prolifer invas metastasi cancer cell studi aim demonstr lung cancer patient high fhl express wors overal surviv os relaps free surviv rfs
D014157;D008175
T191;T123;T116
36,227,137
morpholog descript molecular characteris dactylogyrus matlopong sp n monogenea dactylogyrida south african endem labeobarbus aeneus cyprinida torina dactylogyrus dies speci rich genus platyhelminth document speci most strict specif freshwat cyprinoid morpholog dactylogyrus group afrobarba type carpathicus type pseudoanchoratus type varicorhini type known occur africa studi describ new speci dactylogyrus varicorhini type gill endem smallmouth yellowfish labeobarbus aeneus burchel vaal river free state provinc south africa dactylogyrus matlopong sp n uniqu among varicorhini type congen main accessori piec male copulatori complex present hook shape subunit defin round base reach male copulatori organ combin presenc conspicu medial project anterior margin ventral bar sequenc partial rrna gene togeth entir region generat first time speci dactylogyrus south africa concaten phylogenet analys select dactylogyrus spp show parasit group accord morpholog type
D003530;D005393;D010986;D014200
T047;T013;T204
36,227,136
senp affect express pycr promot bladder cancer prolifer emt transform desumoyl stat abnorm activ signal transduc activ transcript stat found various type human cancer includ bladder cancer bc studi examin regul stat post translat modif ptms found senp high bladder cancer sentrinsumo specif proteas senp stat high express bc tissu compar tissu adjac carcinoma senp induc stat protein level p stat transloc nuclear desumoyl stat nuclear stat transcript activ factor promot pyrrolin carboxyl reductas pycr gene protein level interact promot pycr next found knockdown pycr inhibit epitheli mesenchym transit bladder cancer simultan mitig carcinogen effect stat vitro stat knockdown bladder cancer cell inhibit cell prolifer migrat invas contrast senp overexpress revers effect result lend novel insight regul stat key role bladder cancer progress
D050796;D001749
T191;T123;T116
36,227,134
activ charcoal dental product evid effect lack societi trend toward avoid artifici compon call natur product gain space peopl attent recent year activ charcoal base dental product promin exampl movement promis remov extrins stain whiten teeth natur mean product gain popular among patient compani explor market launch charcoal base activ charcoal base dentifric mouthrins toothbrush whiten product easili found nearbi store internet
D003802;D014073;D014075
T061;T122;T033
36,227,133
current adhes protocol indirect ceram restor indirect ceram restor common use restor function esthet vital nonvit teeth well dental implant advanc digit dentistri massiv adopt comput aid designcomput aid manufactur cadcam system clinician dental assist involv manufactur process indirect ceram restor need understand best clinic indic materi respect adhes protocol
D015921;D017267
T074;T170
36,227,132
coronectomi altern complic full boni impact tooth remov remov impact teeth common offic base oral maxillofaci surgic procedur complic associ procedur uncommon howev mandibl close proxim third molar inferior alveolar nerv potenti lead temporari perman sensori disturb intent partial odontectomi coronectomi procedur surgic option aim mitig reduc incid potenti risk complic
D014081;D014095;D061221
T061;T047;T037
36,227,131
reconstruct peri implant papillari soft tissu esthet area use interdent tissu tuberos connect tissu graft tunnel approach case report long term surviv dental implant fulli partial edentul patient proven success report literatur howev mainten soft tissu qualiti volum often difficult due multipl surgeri involv implant placement physiolog resorpt bone tooth extract soft tissu augment frequent necessari improv soft tissu contour done simultan implant abut placement follow final insert implant support prosthes purpos case report demonstr surgic procedur use augment peri implant buccal soft tissu defect use interdent palat tissu pocket reduct procedur combin distal wedg graft tuberos connect tissu util tunnel approach esthet area implant restor report case deliv year prior soft tissu reconstruct
D015921;D019250
T074
36,227,130
impact digit dentistri interdisciplinari esthet treatment digit dentistri continu improv asynchron communic across dental team elev clinic outcom patient digit analys plan complex interdisciplinari case carri high predict accur manner print surgic prepar guid made definit digit smile design invalu tool improv accuraci precis clinic intervent help limit human error increas predict moreov current cadcam ceram materi pair proper adhes bond protocol facilit function esthet success long term clinic report describ illustr digit treatment plan interdisciplinari surgic restor treatment high complex clinic case requir esthet rehabilit
D004955;D012904
T054;T091
36,227,127
assign speci inform correspond gene sequenc label framework automat assign speci inform correspond gene research articl critic import step gene normal task wherebi gene mention normal link databas record identifi text mine algorithm exist method typic reli heurist rule base gene speci co occurr articl accuraci suboptim therefor develop high perform method use novel deep learn base framework identifi whether relat gene speci instead tradit binari classif framework possibl pair gene speci articl evalu treat problem sequenc label task fraction pair need consid benchmark result show approach obtain signific higher perform compar rule base baselin method speci assign task accuraci sourc code data speci assign freeli avail databas url https githubcomncbispeciesassign
D057225;D012984
T090;T170;T066;T073
36,227,121
distinct uroplakin ii stain pattern apocrin breast carcinoma uroplakin ii upii shown high specif marker urotheli carcinoma howev also stain subtyp apocrin differenti breast carcinoma given urothelium breast epithelium share common immunohistochem marker ck gata lead potenti diagnost pitfal stain cohort tripl negat breast cancer upii compar diffus cytoplasm stain urotheli carcinoma upii posit apocrin carcinoma cours granular cytoplasm stain pattern negat nonapocrin tripl negat breast cancer case furthermor stain pattern present apocrin metaplasia breast apocrin sweat gland normal skin distinct subcellular local upii stain breast carcinoma offer potenti solut diagnost pitfal
D002295;D064726;D001749;D013544;D001943;D001859
T191
36,227,111
explor physiolog instructor use core concept pedagog factor influenc choic cours topic physiolog core concept design guid instructor undergradu physiolog cours howev although past work character align physiolog program core concept unclear extent core concept influenc instructor pedagog decis repres core concept across physiolog cours survey undergradu physiolog instructor determin familiar core concept impact core concept teach well align cours core concept instructor report predomin reli textbook past syllabi cours resourc influenc instruct decis topic includ cours howev mani instructor report reorgan physiolog cours subsequ iter reduc number concept cover allow time critic think activ learn addit find major instructor indic knowledg list physiolog core concept influenc core concept limit even report familiar list core concept final find instructor report uneven coverag physiolog core concept cours core concept ubiquit other spars cover conclud discuss implic work physiolog educ communiti call continu develop resourc support new physiolog instructor need promot coverag certain core concept physiolog cours new noteworthi physiolog core concept critic resourc undergradu physiolog instructor despit littl past work investig impact core concept across institut find instructor unfamiliar core concept instead reli resourc develop revamp physiolog cours also identifi uneven coverag core concept curriculum offer implic physiolog educ communiti
D003479;D018794
T065;T170
36,227,108
foxp foxoa prognost marker gallbladd squamous celladenosquam carcinoma adenocarcinoma patholog characterist squamous celladenosquam carcinoma scasc well clarifi rare subtyp gallbladd cancer gbc biolog marker diagnosi prognosi avail research evalu express foxp foxoa scasc adenocarcinoma ac sampl analyz via immunohistochemistri scasc associ higher rate lymph node metastasi invas patient older year compar ac foxp foxoa posit rate signific lower scasc ac sampl patient larg tumor size high tnm stage lymph node metastasi invas histori tumor resect biopsi posit foxp express level signific decreas case poor differenti ac univari kaplan meier analysi reveal negat foxp foxoa express poor differenti larg tumor size high tnm stage lymph node metastasi invas inabl undergo curat resect close associ decreas overal surviv scasc ac patient multivari cox regress analysi show negat foxp foxoa express level independ predictor poor prognosi scasc ac patient result indic negat foxp foxoa express close associ pathogenesi clinicopatholog properti prognosi gbc patient foxp foxoa may thus biomark gbc carcinogenesi progress prognosi
D005706;D018196;D000230;D002294
T191
36,227,105
machin learn techniqu predict braf mutat status cutan melanoma clinic histopatholog featur melanoma cutan neoplasm respons patient death countri braf mutat common driver mutat develop molecular target therapi precis knowledg braf status becom increas import evalu braf mutat status routin perform polymeras chain reaction time consum expens techniqu immunohistochemistri suggest cheaper altern gain general accept retrospect observ studi cohort patient invas melanoma conduct order develop evalu machin learn approach predict braf status use clinic histolog variabl compar perform differ common machin learn algorithm use shapley addit explan shap explain individu predict extract medic insight defin heurist model estim braf mutat probabl extrem gradient boost algorithm obtain best perform interpret model show import variabl estim braf mutat probabl age breslow thick breslow densiti base interpret medic knowledg simplifi heurist model propos predict braf status use variabl obtain perform area curv propos heurist model could use clinician obtain good estim braf mutat probabl
D008545;D012878
T191
36,227,103
ehr integr clinic pathway promot educ confid save time primari care provid computer clinic decis support tool increas necessari widespread primari care due rapid evolv evid shift clinic guidelin clinic pathway subtyp clinic decis support tool aim link evid practic requir evalu benefit barrier use inform user center design object describ use perceiv benefit barrier evid base diseas specif electron health record pathway clinic decis support primari care provid larg integr health system survey use clinic pathway use onlin questionnair distribut via email novemb descript statist estim differ characterist respons pathway use assess use chi squar fisher exact test survey respons rate differ respons rate provid practic type academ versus communiti p differ found demograph use pathway versus accord role age length time practic provid academ practic like communiti practic use pathway among provid use pathway agre evid base inform agre allow take better care patient agre guid clinic decis agre save time main barrier use pathway forget among use pathway unawar pathway exist analysi demonstr primari care provid adopt clinic pathway perceiv benefit sever domain largest barrier adopt user forgot pathway unawar futur work focus dissemin educ improv tool access content optim balanc complex effici
D019091;D020000
T058;T170
36,227,098
droplet digit pcr ddpcr novel technolog detect ctnnb mutat desmoid fibromatosi desmoid fibromatosi df local aggress soft tissu neoplasm frequent recurr df character alter wnt catenin pathway major show sporad mutat ctnnb wherea other germlin mutat apc immunohistochem stain catenin often difficult interpret negat case prior studi shown dfs lack nuclear express catenin may carri activ ctnnb mutat droplet digit polymeras chain reaction ddpcr use effect detect mutat formalin fix paraffin embed ffpe sampl various cancer type studi assess diagnost util ddpcr detect ctnnb mutat df catenin express immunohistochemistri ihc well diagnost challeng case dfs nuclear catenin express ihc case show ctnnb mutat ddpcr use primer common point mutat ctnnb frequent mutat ta n follow sf n sp n identifi addit myo fibroblast lesion uncertain classif negat nuclear catenin express ihc detect ctnnb mutat unknown lesion includ sf n sp n ddpcr sensit rapid cost effici methodolog detect common ctnnb mutat df especi diagnost challeng case
D051176;D018222
T191;T123;T116
36,227,075
pregnant women percept secondhand smoke exposur birth outcom includ low birth weight preterm birth delay infant neurodevelop associ secondhand smoke exposur pregnant purpos studi explor pregnant women perspect secondhand smoke exposur understand experi inform recommend
D047928;D014028
T069;T046;T033
36,227,074
effect acupressur lactat integr review assess effect acupressur lactat
D019050;D015670
T061