Javtor/biomedical-topic-categorization-validation

PMID int64 35.7M 36.4M	Title/Abstract stringlengths 22 8.78k	MeshTerms stringlengths 7 101	SemanticTypes stringlengths 4 64
36,333,051	execut plan combat covid unit state sever acut respiratori syndrom coronavirus sar cov emerg late date coronavirus respons greater million case unit state million confirm death virus came unit state test unorgan effect treatment known vaccin discov plan correct defici cooper scienc effici clinic trial implement combat novel virus plan develop effici inexpens test high effect medicin treat prevent diseas progress vaccin immun popul	D000086382	T047;T067
36,333,039	status epilepticus neurolog emerg review discuss treatment consider status epilepticus general intens care unit patient acquir brain injuri autoimmun condit toxidrom pediatr pregnanc	D004569;D013226	T060;T047;T034
36,333,038	advanc intracrani hemorrhag subarachnoid hemorrhag intracerebr hemorrhag aneurysm subarachnoid hemorrhag intracerebr hemorrhag devast injuri caus signific morbid mortal howev advanc made decad improv outcom review summar systemat approach stabil treat patient popul	D013345;D002545;D002532	T047;T046;T190
36,333,037	neurocrit care aspect ischem stroke manag articl review care patient ischem stroke intens care unit includ earli general critic care intervent airway control blood pressur goal accord type acut stroke treatment poststrok cerebr edema manag hemorrhag convers ischem stroke fibrinolyt revers manag carotid endarterectomi infect endocard import prevent common intens care complic discuss includ aspir pneumonia deep venous thrombosi urinari tract infect cardiac arrhythmia hyperglycemia	D002545;D000083242;D020521	T047;T046
36,333,036	neurocrit care research collabor cure coma one common question ask famili member patient brain injuri coma love one wake despit substanti improv care patient neurolog diseas medic scientif communiti struggl answer simpl question import technolog treatment strategi improv trajectori patient impair conscious acut set limit cure coma campaign develop neurocrit care societi multispecialti multi interest communiti research caretak focus patient disord conscious doc acut phase care first year group sever public focus identifi gap knowledg encourag research area review current understand doc review work cure coma campaign identifi gap knowledg highlight	D003128;D001930	T047;T037;T048
36,333,035	neurocrit care educ unit state neurocrit care relat young subspecialti rapid come neurocrit care communiti expand process train credenti physician grow field undergon rapid evolut articl review histori current state neurocrit care train educ physician certif program accredit unit state within larger context critic care train across subspecialti	D000068;D003422	T058;T064
36,333,034	artifici intellig big data scienc neurocrit care recent year volum digit web base inform util modern comput base technolog data storag process analysi grown rapid human process limit number variabl given time thus delug clinic use inform intens care unit environ remain untap innov machin learn technolog develop deep neural network effici cost effect data archiv system provid infrastructur appli artifici intellig big data determin clinic event outcom introduc comput base technolog test across domain	D001185;D000077558	T090;T170;T073;T066
36,333,033	physiolog monitor patient acut brain injuri multimod approach neurocrit care manag acut brain injuri abi focus identif prevent manag secondari brain injuri sbi physiolog monitor brain organ system role predict patient recoveri deterior guid individu therapeut intervent measur respons treatment goal improv patient outcom review detail specif physiolog marker brain injuri neuromonitor tool integr use abi patient develop therapeut approach prevent sbi	D003422;D001930	T058;T037
36,333,032	brain deathdeath neurolog criteria intern standard world brain death project articl review criteria determin brain death discuss import protocol develop review intern effort standard clinic test	D001926	T046
36,333,031	neuropharmacolog intens care unit clinician must individu pharmacotherapi patient acut neurolog injuri base multipl factor includ age comorbid chronic medic use mani pharmacokinet pharmacodynam properti alter acut ill particular absorpt distribut metabol elimin may result loss drug effect toxic articl provid clinician general pharmacolog knowledg follow drug regimen common prescrib neurocrit ill adult sedat analges osmotherapi antiseizur medic antishiv agent vasoact agent antithrombot revers agent	D009480;D007362	T091;T093;T073
36,333,029	neurocrit care general intens care unit neurolog condit often encount general intens care unit articl discuss common neurolog issu encount provid guidanc assess manag condit	D007362;D009422	T047;T073;T093
36,333,028	neuroprognost patient sever acut brain injuri left incapacit critic ill unabl make medic decis surrog decis maker must make life death decis patient reli clinician prognost guidanc guidelin current exist guid clinician prognost henc neuroprognost still consid art leav room high variabl review examin current literatur prognost neurocrit care identifi ongo challeng exist field provid suggest futur research goal amelior variabl focus scientif patient center rather artist approach prognost	D016638;D003657	T047;T041
36,333,027	neuromuscular weak intens care diseas peripher nervous system creat addit diagnost conundrum within intens care set caus vast present myriad symptom often ill defin misidentifi care benefit multidisciplinari approach includ neuromuscular specialist rehabilit servic specialti pharmacist addit neurocrit care team general survivor achiev good function recoveri relat preintens care unit baselin	D009468	T019;T047
36,333,026	neurotrauma intracrani pressur manag although intracrani pressur icp monitor mainstay traumat brain injuri tbi manag decad new understand tbi physiopatholog call paradigm shift complex tbi manag preclud icp taken isol valu specif threshold multimod monitor crucial expand comprehens individu pathophysiolog allow precis tailor treatment approach articl review key concept interpret appli publish icp manag guidelin statement	D007427;D000070642	T037;T042
36,333,025	histori neurocrit care subspecialti role neurointensivist subspecialist cement modern medicin global forg collabor neurologist neurosurgeon internist anesthesiologist general surgeon emerg medicin physician pediatrician critic care area requir multiprofession environ neurocrit care har knowledg technolog resourc research opportun embrac multisystem approach care neurolog critic ill although recent formal recogn crucial role serv patient acut life threaten neurolog insult well establish	D003422	T058
36,333,017	ischem stroke patient malign approxim one quarter one third patient ischem stroke embol stroke undetermin sourc esus estim patient esus activ cancer diagnosi presenc cancer potenti increas risk acut ischem stroke various mechan cancer relat hypercoagul intracrani tumor lead arteri compress intracardiac tumor lead cardioembol certain cancer therapeut also contribut risk ischem stroke multipl vascular lesion involv bilater anterior posterior circul high plasma dimer level elev inflammatori marker might suggest cancer relat ischem stroke patient ischem stroke relat malign also higher risk stroke recurr earli neurolog deterior mortal cancer screen acut ischem stroke patient consid etiolog stroke establish clinic histori tobacco use unexplain constitut symptom fever night sweat unexplain weight loss suggest under malign select antithrombot secondari stroke prevent remain controversi clinic trial data use antiplatelet therapi vs anticoagul esus cancer patient limit futur clinic trial specif focus patient ischem stroke relat malign need guid appropri therapeut agent select	D000083242;D020766;D020521;D009369	T047;T191
36,333,015	clinician adopt artifici intellig algorithm detect left ventricular systol dysfunct primari care compar clinician characterist high adopt low adopt artifici intellig ai enabl electrocardiogram ecg algorithm alert possibl low left ventricular eject fraction ef subsequ effect detect patient low ef	D001185;D018487	T090;T046;T073;T066
36,333,014	plant base diet caus cardiovascular mortal nationwid cohort spain enrica studi investig associ health plant base diet index hpdi unhealth plant base diet index updi caus cardiovascular diseas cvd mortal spanish adult	D014676;D002318	T061;T033;T047
36,333,004	target environment risk prevent rheumat diseas target environment factor import way reduc incid rheumat diseas rds approach may popul level furthermor emerg abil identifi individu high risk develop futur rd allow person approach environment modif prevent articl discuss challeng opportun target environment factor prevent rds	D012216	T047
36,333,003	environment risk factor osteoarthr impact individu knee joint injuri osteoarthr debilit chronic condit involv joint degener impact million peopl worldwid place high social econom burden societi knee common joint impact osteoarthr common caus osteoarthr traumat joint injuri specif injuri anterior cruciat ligament purpos review detail non modifi modifi risk factor osteoarthr particular focus individu anterior cruciat ligament injuri read health care provid better comprehend wide varieti factor link osteoarthr	D020370;D007718;D000070598	T047;T037
36,333,002	environment trigger hyperuricemia gout gout preval type inflammatori arthriti worldwid environment factor contribut hyperuricemia risk gout flare caus hyperuricemia includ increas purin consumpt meat alcohol high fructos corn syrup well medic cyclosporin low dose aspirin diuret trigger gout flare includ increas purin consumpt medic use urat lower therapi diuret environment exposur includ lead exposur particul matter exposur temperatur fluctuat physiolog stress found trigger flare right clinic scenario factor consid treat gout patient	D006073;D033461	T047
36,333,001	environment trigger vascul system vasculitid autoimmun diseas character vascular inflamm type vascul thought result antigen exposur genet suscept individu suggest like role environment trigger condit season geograph variat incid provid insight potenti role environment exposur diseas mani data support infecti trigger vasculitid wherea studi identifi noninfecti trigger airborn pollut silica smoke heavi metal review known suspect environment trigger giant cell arter takayasu arter polyarter nodosa kawasaki diseas antineutrophil cytoplasm antibodi associ vascul	D010488;D001327;D056648;D013700;D013625	T047
36,333,000	environment risk inflammatori myopathi date review extern environment factor adult onset idiopath inflammatori myopathi iim environment factor suggest evid includ ultraviolet radiat smoke infecti agent virus particular pollut medic ie statin vitamin defici discuss also discuss potenti implic environment factor iim develop identifi current challeng provid insight futur investig	D014466;D009220	T047;T070
36,332,999	environment risk system sclerosi increas bodi literatur suggest relationship environment factor develop system sclerosi ssc includ occup exposur chemic materi medic alter microbiom dysbiosi environment exposur may impact epigenet regul therebi trigger aberr immun respons result clinic serolog phenotyp diagnos ssc screen studi putat trigger improv understand pathogenesi ssc also inform institut protect measur	D012595;D016273	T047;T037
36,332,998	system lupus erythematosus risk role environment factor system lupus erythematosus sle complex chronic autoimmun diseas etiolog sle multifactori includ potenti environment trigger may occur sequenti multi hit hypothesi review focus sle risk potenti associ environment factor includ infect microbiom diet respir exposur eg crystallin silica smoke air pollut organ pollut heavi metal ultraviolet radiat	D004781;D008180	T047;T037
36,332,997	environment risk spondyloarthropathi spondyloarthropathi also known spondyloarthr encompass spectrum diseas classifi axial peripher musculoskelet manifest extra articular featur common spa make system rheumatolog diseas involv skin eye gut organ systemsresearch identifi risk factor develop spondyloarthr particular regard genet suscept strong associ hla b multipl studi elucid clinic risk factor associ spa diseas activ sever review aim explor environment risk factor spondyloarthr	D025242;D025241;D013167	T047
36,332,996	lifestyl hormon metabol environment risk rheumatoid arthriti although substanti bodi literatur focus understand noninhal risk factor rheumatoid arthriti data mix often conflict given health benefit certain lifestyl modif seem reason clinician promot healthi lifestyl habit relat diet exercis mainten health weight mainten good dental hygien overal howev lifestyl modif may expect modest benefit strategi prevent rheumatoid arthriti high risk patient need	D008019;D001172	T047;T054
36,332,995	inhal addit mucos relat environment risk rheumatoid arthriti rheumatoid arthriti ra occur result complex interplay environment factor genet suscept individu consider evid lung may serv initi site toler loss generat ra relat autoimmun sever environment inhal exposur lung diseas associ ra risk addit evid immun microbi dysregul mucos site includ oral gastrointestin mucosa may contribut develop ra epidemiolog evid link mucos exposur various environment insult risk determin ra review	D001172	T047
36,332,994	epidemiolog opportun challeng studi environment risk factor rheumat diseas rheumat diseas stronger environment hereditari etiolog articl summar key environment risk factor rheumat diseas data sourc generat find key pitfal exist research everi rheumatolog clinician know emerg research opportun hold promis revolution field soon	D012216;D012219	T047;T091
36,332,966	adolesc profession experi metabol bariatr surgeri requir preoper postop support mhealth qualit studi studi aim explor adolesc profession incent experi metabol bariatr surgeri mbs explor perceiv need requir preoper postop support mhealth intervent improv long term healthi lifestyl behaviour health outcom	D017216;D050110	T061;T058
36,332,965	common mental disord associ factor among high school student debr marko town northwest ethiopia institut base cross section studi common mental disord includ anxieti depress somat symptom pose signific public health problem serious effect person well social occup function also affect health qualiti life peopl adolesc age group vulner differ factor accord american psychiatri associ adolesc fulfil criteria least one common mental disord despit high burden disord limit studi ethiopia therefor studi provid preval common mental disord among student ethiopia	D011788;D001523	T078;T048
36,332,964	investig associ il antagonist therapi blood coagul critic ill patient covid protocol prospect observ multicentr studi hypercoagul one main featur covid induc hyperinflammatori respons shift balanc haemostasi toward pro coagul interleukin il antagonist therapi recommend certain subgroup critic ill patient covid modul inflammatori respons interact immun respons haemostasi well recognis therefor object evalu whether modul inflammatori respons il antagonist inflict chang whole blood coagul assess viscoelast method critic ill patient covid	D000086382	T047;T067
36,332,963	global map exercis intervent among covid survivor protocol scope review covid pandem pose unparallel threat dimens human health well pan american health organ acknowledg crucial role rehabilit therapi covid emphasis import exercis programm covid survivor scope review outlin strategi systemat review publish unpublish literatur investig volum evid exercis intervent covid survivor	D000086382	T047;T067
36,332,962	preval harm tradit practic pregnanc associ factor southwest ethiopia communiti base cross section studi assess preval harm tradit practic pregnanc associ factor southwest ethiopia	D011295;D037841	T058;T098
36,332,961	factor associ adolesc sexual experi base biopsychosoci model cross section studi use korea youth risk behavior web base survey kyrb sexual activ import integr behaviour interact biolog psycholog social factor among various chang adolesc howev start sex earli age associ advers outcom thus studi aim investig factor associ adolesc sexual experi base biopsychosoci model	D012309;D000294	T055
36,332,960	opioid prescript usag surgeri opera protocol prospect multicentr observ cohort studi opioid use surgeri postop pain common frequent address opioid analgesia practic must balanc benefit achiev adequ pain relief harm advers effect opioid induc ventilatori impair opioid use disord student traine led collabor studi aim investig compar prescript versus consumpt opioid day postdischarg common surgic procedur impact patient report outcom regard postop pain	D000701;D009293	T121;T048;T131;T109
36,332,959	impact multifacet intervent physician knowledg attitud practic relat pharmaceut incentivis protocol randomis control trial set privat sector constitut larger part health system profit gather take primaci patient well interact pharmaceut compani privat general practition gps experi conflict interest coi situat wherebi imparti gps profession decis make may influenc secondari interest financi gain prescrib specif pharmaceut brand	D001291;D058005	T097;T041
36,332,958	danc manag qualit studi explor perspect person knee osteoarthr type diabet mellitus impact osteoarthr diabet manag daili life type diabet tdm knee osteoarthr oa common co occur epidemiolog studi suggest concomit symptomat knee oa increas risk tdm complic sought explor experi perspect individu live symptomat knee oa tdm focus impact oa tdm manag daili life	D020370;D003924	T047
36,332,957	use microsimul method assess dynam smoke status gain life expect quit longitudin cohort us older adult previous studi unabl estim dynam smoke status us elder general popul studi assess benefit quit term result gain life expect propos novel method estim per cent quit remain lifetim success quit relaps well life expect particip baselin smoke status	D006278;D016540	T089;T055;T064
36,332,956	patient experi codesign rehabilit intervent hospit rapid review codesign strengthen partnership healthcar worker patient also facilit collabor support develop design deliveri healthcar servic prior rehabilit review focus main clinic organis outcom codesign less focus live experi rehabilit patient	D006282;D006761	T093;T073;T097
36,332,955	factor influenc receipt antibiot prescript among insur patient tanzania cross section studi limit data factor influenc antibiot prescript among insur patient assess correl antibiot prescript among insur patient	D000900;D012141	T121;T047;T195
36,332,954	traumat stress symptom famili caregiv patient acut leukaemia protocol multisit mix method longitudin observ studi diagnosi progress recurr cancer often high traumat famili caregiv fcs systemat assess distress approach prevent treatment lack acut leukaemia al life threaten cancer blood often present acut requir intens treatment associ sever physic symptom consequ traumat stress may common fcs patient al aim determin preval sever longitudin cours predictor traumat stress symptom fcs patient al first year diagnosi understand live experi traumat stress perceiv support need	D009369;D007938	T191
36,332,953	mprep studi protocol prospect cohort studi assess feasibl accept hiv pre exposur prophylaxi prep strategi male client femal sex worker kisumu kenya male client mcs integr sex work driven hiv transmiss dynam sexual partner femal sex worker fsw mcs contribut disproportion incid hiv global sub saharan africa new infect attribut mcs fsw partner key popul gap coverag hiv test prevent servic men includ mcs well document yet research innov intervent improv mc uptak effect prevent servic includ pre exposur prophylaxi prep scarc	D065129;D060386;D019380;D015658	T061;T121;T098;T097;T047
36,332,952	effect mind base stress reduct adult sleep disturb updat systemat review meta analysi mind base stress reduct mbsr medit base therapi origin recommend stress manag howev current use allevi sleep disturb therefor contemporari systemat review aim elucid clinic effect mbsr sleep qualiti sleep relat daytim impair adult sleep disturb includ chronic insomnia disord	D064866;D007319;D012893;D009369	T184;T191;T047;T041;T048
36,332,951	declar interest work cross section studi declar interest healthcar practic scotland england understand arrang healthcar organis declar staff interest scotland england context current recommend	D013222;D006282	T064;T097
36,332,950	compar efficaci complic long act intermedi act insulin regimen adult type diabet individu patient data network meta analysi examin compar efficaci complic long act intermedi act insulin differ patient characterist type diabet mellitus tdm	D003922;D007003	T047
36,332,949	risk cardiovascular event lead hospitalis streptococcus pneumonia infect retrospect cohort life studi elucid risk cardiovascular event occurr follow streptococcus pneumonia infect	D001281;D020521;D006333;D003327;D011008	T047;T046
36,332,948	mortal indic qualiti neurosurg care england retrospect cohort studi postop mortal wide use qualiti indic may unreli procedur number andor mortal rate low due insuffici statist power object investig statist valid postop day mortal qualiti metric neurosurg practic across healthcar provid	D017558;D019635	T061
36,332,947	number type neurolog emerg england influenc socioeconom depriv retrospect analysi hospit episod statist data first larg scale analysi neurolog emerg admiss england determin number type emerg admiss neurolog emerg diagnost code mani care neurologist neurosurgeon admiss vari level depriv	D004630;D004827	T033;T047;T046
36,332,946	radiofrequ assist transect pancrea versus stapler distal pancreatectomi studi protocol multicentr randomis clinic trial transpair date pancreat stump closur techniqu shown superior distal pancreatectomi although sever studi shown trend toward better result transect use radiofrequ devic radiofrequ assist transect rft randomis trial purpos perform date therefor design randomis clinic trial hypothesi techniqu use distal pancreatectomi superior reduc clinic relev postop pancreat fistula cr popf mechan closur	D010180;D011788	T061;T078
36,332,945	protocol systemat review effect patient posit rapid sequenc intub rapid sequenc intub rsi advanc airway techniqu perform endotrach intub patient high risk aspir although rsi recognis life save techniqu perform mani physician various set emerg depart intens care unit still lack consensus various featur procedur notabl patient posit previous expert comment uniqu drawback benefit various posit studi publish compar patient posit affect endotrach intub context rsi purpos systemat review compil exist evid understand compar differ patient posit potenti affect success rsi	D007442;D000079603	T061
36,332,944	navig youth mental health addict protocol realist review synthesi approach practic navmap standard project mental health andor addict mha concern affect approxim million children youth canada yet less receiv appropri treatment concern youth receiv appropri support may disengag care may experi last mha issu famili youth also support find access care thus system support need help youth famili find equit access appropri care navig innov mha care provid patient centr support care plan help individu famili overcom barrier care despit increas avail navig servic youth mha concern practic model vari singl sourc synthesis evid regard approach outcom popul comprehens standard	D008605;D016739	T058;T048
36,332,942	develop algorithm determin heart failur reduc preserv eject fraction use nationwid electron healthcar record uk determin heart failur hf phenotyp routin electron health record ehr challeng aim develop valid ehr algorithm identif specif hf phenotyp use read code combin select patient characterist	D006333	T047;T046
36,332,941	develop contemporari communiti clinic patient heart failur preserv eject fraction within current nation health servic model diagnost therapeut arsenal heart failur preserv eject hfpef expand novel therapi eg sodium glucos co transport inhibitor firmer recommend optimis non cardiac comorbid unclear outpati hfpef model adequ deliv therefor evalu efficaci exist dedic hfpef clinic find innov way design comprehens model tailor modern era hfpef	D006333;D000086382	T047;T046;T067
36,332,939	free educ materi eular school rheumatolog websit lot educ content includ free educ materi interest rheumat musculoskelet diseas rmds eular school rheumatolog esor websit easi access three click take straight content need search esor web browser click catalog click free learn materi choos need one click particular eular imag librari eular learn materi ra give lot imag slide help present eular long histori provid educ rheumatologist health profession rheumatolog peopl rmds commit educ enshrin eular strategi alway larg part eular	D012219;D001172;D009140	T047;T091
36,332,938	peripher spondyloarthr psoriat arthriti sine psorias deal semant clinic meaning differ diagnos peripher spondyloarthr pspa remain signific challeng due lack specif diseas biomark overlap spa subtyp main psoriat arthriti psa repres diagnost challeng particular absenc skin psoriasi psa sine psorias narrat review aim compar epidemiolog genet suscept pathophysiolog classif criteria diseas phenotyp burden therapeut guidelin patient diagnos pspa psa sine psorias determin two entiti consid joint distinct global pspa appear inclus compar psa sine psorias area similar includ age onset number joint involv preval axial involv howev patient pspa male gender predomin higher preval hla b enthes involv larg joint lower limb wherea patient psa sine psorias higher preval hla cw dactyl involv hand distal interphalang joint therefor differ pspa psa sine psorias goe beyond semant dissimilar drive scientif effort reach better characteris pspa individu diseas accord randomis clinic trial target patient well defin pspa identifi effect therapi popul	D015535;D025241;D011565	T047
36,332,937	improv pregnanc counsel contracept counsel document singl rheumatolog academ practic qualiti improv project purpos qualiti improv project improv rate pregnanc counsel document regard risk teratogen medic includ leflunomid mycophenol methotrex cyclophosphamid women childbear age year goal increas document rate month first perform emr chart review women seen month prior intervent faculti singl rheumatolog academ centr determin mani women document contracept pregnanc counsel includ written document anywher note icd code specif pregnanc counsel contracept counsel intervent implement percentag women document pregnanc counsel chang preintervent postintervent preintervent women receiv document pregnanc counsel postintervent women receiv document pregnanc counsel percentag women document contracept counsel howev chang preintervent postintervent preintervent women receiv document contracept counsel postintervent women receiv document contracept counsel improv	D058996;D012219	T091;T057
36,332,936	awhonn postpartum discharg educ patient knowledg sustain object evalu whether implement associ women health obstetr neonat nurs awhonn postpartum discharg educ initi associ improv patient knowledg warn sign sever matern morbid smm initi self sustain	D010351;D049590	T101;T058;T079
36,332,934	hilar tuberculosi versus klatskin tumour diagnost challeng hepatobiliari tuberculosi rare condit caus obstruct jaundic either enlarg lymph node around bile duct involv biliari epithelium tubercul process sinc tissu diagnosi mandatori proceed resect initi liver transplant protocol benign lesion occasion misdiagnos hilar cholangiocarcinoma present case hepatobiliari tuberculosi present obstruct jaundic due hilar obstruct mass caus obstruct later found pseudotumour typic tuberculosi diagnosi meant extens surgic resect protocol cholangiocarcinoma avoid patient recov complet cours antitubercular therapi	D018285;D041781;D001650;D018281;D014376	T047;T191
36,332,932	spindl cell sarcomatoid tumour trachea rare primari malign tumour spindl cell carcinoma subtyp sarcomatoid carcinoma previous describ various anatom locat though rare tracheaw present case woman present sore throat stridor fibreopt nasendoscopi demonstr tracheal mass occupi airway cricoid cartilag third tracheal ring infiltr thyroid gland subsequ ct demonstr pulmonari emboli vertebr metastasi biopsi infiltr thyroid confirm diagnosi spindl cell carcinoma length tumour metastasi present made surgic unresect refer palliat stent die acut deteriorationthi patholog report five time previous literatur manag strategi vari great patient primari tracheal tumour difficult manag due rariti clear guidelin	D014134;D012509;D002277;D012983;D013964	T191
36,332,931	diagnosi system lupus erythematosus earli manifest eosinophil pleural effus woman histori crohn diseas present emerg depart dyspnoea cough intermitt fever evalu reveal pleural effus neutrophil predomin initi suspicion infect prompt short cours antibiot therapi howev patient subsequ develop recurr pleural effus eosinophil predomin serolog data confirm diagnosi system lupus erythematosus sle patient start appropri treatmentthi case present initi manifest eosinophil domin pleural effus sle current guidelin treat pleural effus explor rheumatolog caus howev believ case demonstr valu prompt investig rheumatolog aetiolog otherwis unclassifi eosinophil predomin pleural effus investig includ serolog data import confirmatori marker diagnosi sle	D010996;D008180;D012216	T047
36,332,928	improv access medicin lesson year drug reform china china initi healthcar reform provid access afford healthcar summaris china drug reform use framework china initi comprehens drug polici address differ issu includ issu amend major regul chang institut set implement market authoris holder system bioequival assess improv qualiti drug leverag acceler market approv insur list encourag need driven innov improv access new drug introduc compulsori licens address major public health threat need scale nation essenti medicin polici introduc pharmacoeconom evalu nation reimburs drug list promot ration use medicin evid base select appli differenti price strategi scale zero mark polici form new financ mechan adapt bulk procur place strict regul suppli chain manag ensur suppli reduc cost empow pharmacist improv ration use medicin use procur suppli chain digit platform inform decis improv effici china drug reform adopt phase system approach mobilis multipl polici lever includ govern regul financ despit progress emerg challeng implement coordin capac need address cross cut lesson china drug reform includ align drug reform overal health reform adapt system approach mobilis polici lever stakehold inform polici decis conduct pilot studi	D018166;D018954	T121;T064
36,332,927	mer tyrosin kinas novel suscept gene sle relat end stage renal diseas lupus nephriti ln common sever manifest sle genet risk nephriti progress end stage renal diseas esrd patient ln remain unclear herein aim identifi novel genet associ ln focus subphenotyp esrd	D008180;D008181;D007676	T047
36,332,660	model growth divers microorgan feast famin enrich polyhydroxyalkano phas biodegrad polym decreas sever environment pollut petroleum plastic pha product mix microbi communiti extens studi lower high pha price howev competit distinct microbi communiti enrich pha accumul mix cultur wide investig thus work develop mathemat model competit pha accumul non pha accumul feast famin enrich strategi develop model success simul publish lab scale experiment data plasticicumulan acidivoran well studi pha accumul store pha cell weight growth kinet pha non pha accumul estim compar valu literatur uncertainti model kinet studi expand model includ addit sub biomass compon heterotroph group result microbi divers microbi communiti observ influenc enrich pha accumul mix cultur addit calibr model appli investig cultiv condit cycl length carbon nitrogen ratio solid retent time success p acidivoran enrich mix cultur develop model appli control cultiv enrich pha accumul larg scale pha product system practition point new model enrich pha accumul develop model simul pha accumul enrich cultur model calibr valid plasticicumulan acidivoran impact microbi divers enrich pha accumul investig short cycl h srt suggest success enrich	D054813;D020563	T007;T109
36,332,654	project outcom univers test treatment generalis hiv epidem zambia south africa hptn popart trial model studi long term impact univers home base test treatment part univers test treatment utt hiv incid unknown made project use detail individu base model effect intervent deliv hptn popart cluster randomis trial	D015658;D058872	T047;T067
36,332,653	impact univers test treatment sexual risk behaviour herp simplex virus type prespecifi secondari outcom analysi hptn popart communiti randomis trial comprehens hiv prevent strategi rais concern knowledg intervent reduc risk hiv infect might mitig individu percept risk result riskier sexual behaviour investig prespecifi secondari outcom hptn popart trial determin whether combin hiv prevent strategi includ univers hiv test treatment chang sexual behaviour specif investig whether evid sexual risk compens	D015658	T047
36,332,652	viral suppress self report art adher year univers test treatment hptn popart communiti randomis trial zambia south africa cross section analysi unaid set target individu antiretrovir therapi art viral suppress use data hptn popart trial report whether introduct univers test treatment affect viral suppress treatment adher among individu self report take art identifi risk factor outcom	D015658;D019380	T121;T047
36,332,611	shariant platform enabl evid share across australian clinic genet test laboratori support variant interpret share genom variant interpret across laboratori promot consist variant assert landscap analysi australian clinic genet test laboratori identifi despit nation accredit bodi recommend encourag laboratori submit genotyp data clinic databas fewer variant share clinvar public databas consult australian laboratori identifi resourc constraint limit routin applic manual process consent issu differ interpret system barrier share inform use defin key need solut requir enabl nation share variant interpret shariant platform use grch grch genom build develop enabl ongo share variant interpret associ evid australian clinic genet test laboratori possibl two way autom share implement disrupt laboratori workflow would minim term use develop consult current restrict access australian clinic genet test laboratori shariant design store compar structur evid promot record resolut inter laboratori classif discrep streamlin submiss variant assert clinvar decemb larg prospect curat variant record particip laboratori share discrep classif identifi variant submit one laboratori demonstr co design clinic laboratori vital develop implement nation variant interpret share effort approach improv inter laboratori concord enabl opportun standard interpret practic	D030541;D007753	T170;T073;T093
36,332,610	carerar canada outcom decad network scienc rare diseas gene discoveri past decad wit rapid evolut rare diseas rd research fuel avail genom wide exom genom sequenc transform technolog introduc research communiti carerar canada consortium launch initi forg follow carerar carerar solv amount three era diagnosi discoveri carerar consortium use exom sequenc recent genom omic technolog identifi molecular caus unsolv rds achiev diagnost yield particip famili includ discoveri deleteri variant gene previous associ diseas continu studi candid variant novel gene famili consortium made signific contribut rd research includ develop platform data collect share instig canadian network catalyz function character research novel gene consortium instrument implement genom wide sequenc public fund test rd diagnosi canada despit success past decad challeng solv rds remain enorm work far must leverag clinic omic data secondari use develop tool polici support safe data share continu explor util new emerg technolog optim research protocol delin complex diseas mechan success approach realm requir offer diagnost clariti famili rds	D035583;D059472	T047;T028
36,332,609	pull wool pathogen eye llama nanobodi inhibitor bacteri sos respons issu structur maso et al discov nanobodi inhibit sos respons escherichia coli target lexa repressor proteas high resolut structur novel lexa nanobodi complex reveal function stabil lexa inact conform prevent co proteolysi reca	D013014;D002161	T045;T015
36,332,608	trap tribbl nanobodi assist structur trib pseudokinas trib member human tribbl pseudokinas famili function molecular scaffold divers signal pathway issu structur jamieson et al report first high resolut structur trib bound nanobodi offer insight activ like state	D017871;D047908	T123;T126;T116
36,332,607	hit hurt pantothen kinas target pathogen fungi issu structur gihaz colleagu develop antifung compound target fungal pantothen kinas pank util high throughput chemic screen along biochem function analys newli solv fungal pank crystal structur high affin inhibitor produc invalu insight mechan fungal pank gain	D017853;D057166	T059;T126;T116
36,332,606	structur function basi mammalian microrna biogenesi dicer microrna mirna rna interfer rnai pathway reli small rnas produc dicer endonucleas mammalian dicer primarili support essenti gene regul mirna pathway specif adapt mirna biogenesi unknown show adapt entail uniqu structur role dicer dexdh helicas domain although mice toler loss putat atpas function complet absenc domain lethal assur high fidel mirna biogenesi structur murin dicer mirna precursor complex reveal dexdh domain helicas unrel structur function lock dicer close state facilit mirna precursor select transit cleavag compet open state stimul dicer bind protein tarbp absenc dexdh domain mutat unlock close state reduc substrat select activ rnai thus dexdh domain structur contribut mammalian mirna biogenesi under mechanist partit mirna rnai pathway	D043244;D035683	T123;T126;T116;T114
36,332,605	lncrna cctt mediat rna dna rna protein interact facilit recruit cenp c centromer dna kinetochor assembl kinetochor assembl centromer central chromosom segreg defect process caus mitot error aneuploidi besid well establish protein network emerg evid suggest involv regulatori rna kinetochor assembl howev remain elus ident rna let alon mechan action critic process report cctt previous uncharacter long non code rna lncrna transcrib arm human chromosom play vital role kinetochor assembl show cctt high local centromer via format rna dna triplex specif interact cenp c help engag blueprint protein centromer consequ cctt loss trigger extens mitot error aneuploidi find uncov non centromer deriv lncrna recruit cenp c centromer shed critic light function centromer dna sequenc anchor point kinetochor assembl	D062085	T123;T114
36,332,604	crispr assist transposit tnsc find thread needl haystack hoffmann et al demonstr rna guid transposon remark sequenc specif due action aaa atpas tnsc recruit transposas correct target site	D029968	T116
36,332,603	context key modul protein multival diseas issu molecular cell song et al demonstr mutat yeat domain enl aberr activ gene express form condens specif genom loci use divers experiment approach author dissect molecular underpin enl mutant condens format	D035602;D014157	T123;T116
36,332,602	terra radap r loop depart alt telomer issu molecular cell kaminski et al yadav et al demonstr radap terra non code rna posit regul altern mechan telomer mainten promot loop format chromatin direct mechan suppress transcript collis event alt telomer synthesi	D059505;D062085	T045;T123;T114;T043
36,332,601	introduc new group leader devin schwepp talk devin schwepp set group univers washington studi quantit mass spectrometri base proteom field constant evolv overcom self doubt go gut hire hope build environ excel inclus trust alway encourag lab member keep ask	D035502;D010560	T054;T057
36,332,572	singl cell transcriptom atlas glial divers human hippocampus across postnat lifespan molecular divers glia human hippocampus tempor dynam lifespan remain larg unknown perform singl nucleus rna sequenc generat transcriptom atlas human hippocampus across postnat lifespan detail analys astrocyt oligodendrocyt lineag microglia identifi subpopul distinct molecular signatur reveal associ specif physiolog function age depend chang abund diseas relev character spatiotempor heterogen gfap enrich astrocyt subpopul hippocamp format use immunohistolog leverag glial subpopul classif refer map reveal divers glia differenti human pluripot stem cell identifi dysregul gene patholog process specif glial subpopul alzheim diseas ad togeth studi signific extend understand human glial divers popul dynam across postnat lifespan dysregul ad provid refer atlas stem cell base glial differenti	D059467;D000544	T081;T047;T048;T086
36,332,571	spatial dynam metabolom identifi metabol cell fate trajectori human kidney differenti accumul evid demonstr import role metabol cell fate determin howev challeng assess metabol spatial resolut acknowledg heterogen cellular dynam tissu microenviron use multi omic platform studi cell type specif dynam metabol complex tissu describ metabol trajectori nephrogenesi develop human kidney exploit situ analysi isotop label shift glycolysi toward fatti acid oxid observ differenti renal vesicl toward shape bodi proxim tubul addit show hipsc deriv kidney organoid character metabol immatur phenotyp fail use mitochondri long chain fatti acid energi metabol furthermor supplement butyr enhanc tubular epitheli differenti matur cultur kidney organoid find highlight relev understand metabol trajectori effici guid stem cell differenti	D057026	T025
36,332,570	uncov emerg hscs human fetal bone marrow singl cell rna seq analysi fetal develop human hematopoiet stem cell hscs colon bone marrow bm self renew sustain hematopoiesi throughout life howev precis timepoint hscs seed bm unclear use singl cell rna sequenc map transcriptom landscap human fetal bm spleen hematopoiet stemprogenitor cell hspcs microenviron post concept week pcws demonstr function hscs capabl reconstitut long term multi lineag hematopoiesi adult nog mice emerg bm pcws contrast function hscs detect spleen pcws compar nich hspc interact bm spleen identifi ligand receptor pair like involv fetal hsc migrat mainten work pave way research mechan under hsc colon human fetal bm provid invalu resourc futur studi hsc develop	D001853;D006412	T023;T025;T024
36,332,569	reciproc regul mesenchym stem cell immun respons mesenchym stemstrom cell mscs exist almost tissu particip tissu regener homeostasi vitro expand mscs employ therapeut autoimmun diseas organ failur mani chronic disord remark repar homeostat mainten function mscs reli interact inflammatori microenviron discuss characterist function mscs differ pathophysiolog condit highlight immunomodulatori function mscs alter accord inflammatori cue hope provid new insight divers immunoregulatori properti mscs tissu regener therapi	D059630;D001327;D045164	T061;T047;T025
36,332,568	vade mecom peel back layer hematopoiesi recent studi demonstr hematopoiet stem cell hscs contribut minim blood immun cell product develop becom activ postnat work also reveal mecom express use distinguish rare hscs abund progenitor aris maintain embryon hematopoiesi	D006410;D006412	T025;T042
36,332,567	function renal collect duct human pscs collect duct kidney control balanc water electrolyt well ph urin maintain bodi homeostasi shi et al recent report natur biotechnolog protocol generat function collect duct cell human pluripot stem cell	D007685	T023
36,332,566	glioblastoma stem cell histarion glioblastoma lethal malign possess rapid evolv microenviron contain necrotichypox area aberr microvasculatur glioblastoma stem cell gscs promot tumor growth recurr treatment resist chen et al find gscs drive integr epigenet metabol control angiogenesi via histamin propos antihistamin potenti therapi	D005909;D001932	T191
36,332,522	user satisfact readi use e health applic futur polish societi earli phase covid pandem cross section studi covid pandem result rapid expans e health servic poland main aim studi assess determin user satisfact readi use e health applic polish societi	D000086382;D057220;D017216	T041;T047;T058;T067
36,332,521	compet framework phd program health inform manag job expect profession compet requir health inform manag studentsgradu constant chang workforc develop requir curricula line new emerg compet although compet framework field one specif phd educ program aim develop compet framework phd program iran	D008490;D063025	T091;T066;T057
36,332,520	polici regul data share cohort via data infrastructur interview studi fund agenc platform construct stimul cohort data share nevertheless mani polici barrier imped data share various intervent propos address barrier includ incent creation data share mandat research	D057766;D033181	T170;T052;T054
36,332,519	creation core compet framework clinic informat genesi maintain relev unit kingdom faculti clinic informat fci embark creation core compet framework respons need provid support work clinic health social care also hold informat role	D008490	T091;T066
36,332,365	mild acut kidney injuri pediatr surgeri associ long term renal dysfunct retrospect cohort studi acut kidney injuri aki sudden deterior renal function common pediatr patient undergo cardiac non cardiac surgeri studi investig associ postop aki kidney dysfunct seen long term advers outcom pediatr patient studi aim determin associ postop aki mild aki vs aki mild aki vs moder sever aki chronic kidney dysfunct ckd seen long term pediatr patient undergo cardiac non cardiac major surgeri	D058186;D051436	T047;T037
36,332,358	transform arm joint coordin hand extern coordin explain non uniform precis hand posit sens horizont workspac peopl perceiv hand posit horizont workspac precis radial azimuth direct closer bodi farther away current explan posit sens non uniform includ spatial asymmetri arm propriocept activ andor cortex map experi depend learn arm postur other investig contribut non uniform postur depend transform arm joint angl sens arm proprioceptor hand posit measur precis hand posit sens bimanu hand mirror posit match task four horizont target form squar front bodi blindfold individu found lower hand precis azimuth radial direct higher azimuth precis close target higher radial precis distant target theoret analyz transform random angl error shoulder elbow hand posit random error horizont plane obtain similar distribut hand posit error predict experiment hand precis ellips orient ellips shape size high correl near orthogon arm stiff ellips orient report literatur conclud joint hand coordin transform respons non uniform precis hand posit sens	D001132;D004551	T029;T030
36,332,298	microbi life strategi high rrna operon copi number facilit energi nutrient flux anaerob digest microbi life strategi reflect rrna operon rrn copi number determin microbi ecolog role howev relationship microbi life strategi energi nutrient flux anaerob digest ad remain elus studi investig microbi rrn copi number express ratio use amplicon sequenc rrna gene rrna monitor ch daili product approxim status energi nutrient flux semi continu ad signific posit correl mean rrn copi number microbi communiti digest ch daili product detect control treatment fed swine manur reduc feedstock complex replac part swine manur fructos appl wast weaken correl feedstock complex increas correl strengthen similar result detect mean rrn express ratio microbi communiti respons mean rrn copi number express ratio communiti feedstock addit differ reduc feedstock complex control treatment well digest straw find reveal novel relationship microbi communiti life strategi energi nutrient flux role feedstock characterist therein ad	D012407;D008372	T167;T028
36,332,297	effect free ammonia shock chlorella sp wastewat concentr depend activ respons enhanc settleabl unstabl microbi activ unsatisfactori settl perform imped develop implement microalg wastewat treatment especi high ammonium wastewat presenc free ammonia fa shock fa due nutrient fluctuat wastewat demonstr primari stress factor suppress microalg activ recent studi clear reveal inhibit mechan fa specif high level mgl inhibit genet inform process photosynthesi nutrient metabol howev effect various fa shock concentr microalg activ settl perform remain unknown limit wastewat bioremedi effici improv process develop herein concentr depend shock fa employ microalga exponenti growth stage effect microalg growth photosynthesi observ result show studi five fa shock concentr rang mgl signific inhibit biomass product sharp reduct photosynthesi decreas fvfm valu observ fa concentr mgl hand fa shock enhanc microalg settl effici fold believ due stimul intra extracellular protein content therebi enhanc extracellular polym substanc ep secret specif fa shock induc higher cellular protein content cost decreas carbohydr fatti acid content improv protein secret fold ep product fa shock induc variat intra extracellular biomolecul support regul protein process export assist excess energi generat fatti acid degrad carbohydr consumpt addit fa shock signific decreas biomass nutrit valu indic fold lower essenti amino acid score near reduc essenti non essenti amino acid ratio slight decreas biodiesel qualiti studi expect enrich knowledg microalg activ settl perform respons fluctuant ammonium concentr wastewat promot develop microalg wastewat treatment	D002708;D058086;D064751	T104;T197;T204;T002
36,332,296	applic bipolar membran electrodialysi simultan recoveri high valu acidalkali salin wastewat depth review develop comprehens util high salin wastewat salt resourc regener consid fundament requir process sustain econom benefit one potenti candid bipolar membran electrodialysi bmed rapid develop recent year treatment salin wastewat differ method direct obtain salt condens wastewat bmed could util convert dissolv wast salt higher valu acid alkali simultan various advantag includ outstand environment effect econom benefit review recent applic bmed wast salt recoveri high valu acidalkali generat salin wastewat systemat outlin base summari economi analysi bmed review role desalin resourc recoveri addit bmed base process integr situ util generat acidalkali resourc discuss furthermor influenc oper factor bmed perform outlin final strategi improv bmed perform conclud furthermor futur applic prospect bmed present work would provid guidanc applic bipolar membran electrodialysi salin wastewat treatment high valu convers salt resourc acid alkali	D062065;D018508	T083;T052;T069;T057
36,332,295	nanopor base long read metagenom uncov resistom intrus antibiot resist bacteria treat wastewat receiv water bodi wastewat treatment plant wwtp effluent discharg could induc resistom enrich receiv water environ howev general lack robust antibiot resist bacteria arb identif method drive mechan resistom accumul receiv environ unclear took advantag enhanc arb recognit nanopor long read distinguish indigen arb accumul wwtp born arb receiv water bodi domest wwtp bioinformat framework name argpor https githubcomsustc xylabargpor construct evalu facilit antibiot resist gene arg arb identif nanopor read arg identif argpor show compar precis recal common adopt blastp base method wherea spectrum arb doubl assembl illumina dataset total identifi arb genera carri arg subtyp receiv seawat whose concentr general time higher clean seawat notabl report primari resistom intrus caus reviv residu microb surviv disinfect treatment wwtp born arb includ sever animalhuman enter pathogen contribut receiv water resistom plasmid class integron reckon major vehicl facilit persist dissemin arg moreov work demonstr import extens carrier identif determin drive forc multifactor coupl resistom boom complic environment condit therebi pave way establish prioriti effect arg mitig strategi	D062065;D058608	T083;T069;T082
36,332,272	evalu onlin interprofession simul workshop obstetr neonat emerg explor student percept learn interprofession aspect obstetr neonat emerg onlin simul base workshop	D008880;D013337;D020375	T065;T091;T097
36,332,265	shortcut thermodynam quasistat oper near term quantum technolog requir develop feasibl implement robust strategi control complex mani bodi system end varieti techniqu call shortcut adiabat develop mani shortcut alreadi demonstr power implement distinct scenario yet often also desir addit approxim strategi avail applic larg class system henc letter take inspir thermodynam propos focus macrost rather microst adiabat dynam identifi process preserv equat state systemat correct obtain adiabat perturb theori demonstr approach improv upon fast quasiadiabat drive appli method quantum ise chain transvers field	D001334	T056
36,332,264	edg state local length critic expon surviv probabl topolog waveguid edg state topolog phase transit observ various platform date verif edg state associ topolog invari most studi yet quantit measur topolog phase transit still lack show direct measur edg state local length surviv probabl employ photon waveguid array demonstr topolog phase transit base su schrieffer heeger model measur surviv probabl lattic boundari show long time limit surviv probabl p e loc loc local length length deriv surviv probabl compar distanc transit point yield critic expon phase boundari experi provid altern rout character topolog phase transit extract key physic quantiti	D011336	T081
36,332,249	activ refriger power inertia present oper principl refriger use inerti effect activ brownian particl local reduc kinet temperatur order magnitud environment temperatur principl exploit peculiar far unknown shape phase diagram inerti activ brownian particl initi motil induc phase separ target cool regim remark activ refriger oper without requir isol wall open rout toward use systemat absorb trap eg toxic substanc environ	D012034;D003080	T070;T066
36,332,248	dynam system modul symmetri extend notion multipol subsystem symmetri general spatial modul symmetri uncov two instanc exponenti quasi period modul provid simpl microscop model one two three dimens seek understand effect long time dynam numer studi stochast cellular automaton evolut obey symmetri prove one dimens period modul symmetri lead diffus scale correl modul finit microscop momentum higher dimens symmetri take form line surfac conserv momenta give rise exot form subdiffus behavior rich spatial structur influenc lattic scale featur exponenti modul hand lead correl infinit long live boundari decay exponenti bulk	D004058	T070

36,333,051

execut plan combat covid unit state sever acut respiratori syndrom coronavirus sar cov emerg late date coronavirus respons greater million case unit state million confirm death virus came unit state test unorgan effect treatment known vaccin discov plan correct defici cooper scienc effici clinic trial implement combat novel virus plan develop effici inexpens test high effect medicin treat prevent diseas progress vaccin immun popul

D000086382

T047;T067

36,333,039

status epilepticus neurolog emerg review discuss treatment consider status epilepticus general intens care unit patient acquir brain injuri autoimmun condit toxidrom pediatr pregnanc

D004569;D013226

T060;T047;T034

36,333,038

advanc intracrani hemorrhag subarachnoid hemorrhag intracerebr hemorrhag aneurysm subarachnoid hemorrhag intracerebr hemorrhag devast injuri caus signific morbid mortal howev advanc made decad improv outcom review summar systemat approach stabil treat patient popul

D013345;D002545;D002532

T047;T046;T190

36,333,037

neurocrit care aspect ischem stroke manag articl review care patient ischem stroke intens care unit includ earli general critic care intervent airway control blood pressur goal accord type acut stroke treatment poststrok cerebr edema manag hemorrhag convers ischem stroke fibrinolyt revers manag carotid endarterectomi infect endocard import prevent common intens care complic discuss includ aspir pneumonia deep venous thrombosi urinari tract infect cardiac arrhythmia hyperglycemia

D002545;D000083242;D020521

T047;T046

36,333,036

neurocrit care research collabor cure coma one common question ask famili member patient brain injuri coma love one wake despit substanti improv care patient neurolog diseas medic scientif communiti struggl answer simpl question import technolog treatment strategi improv trajectori patient impair conscious acut set limit cure coma campaign develop neurocrit care societi multispecialti multi interest communiti research caretak focus patient disord conscious doc acut phase care first year group sever public focus identifi gap knowledg encourag research area review current understand doc review work cure coma campaign identifi gap knowledg highlight

D003128;D001930

T047;T037;T048

36,333,035

neurocrit care educ unit state neurocrit care relat young subspecialti rapid come neurocrit care communiti expand process train credenti physician grow field undergon rapid evolut articl review histori current state neurocrit care train educ physician certif program accredit unit state within larger context critic care train across subspecialti

D000068;D003422

T058;T064

36,333,034

artifici intellig big data scienc neurocrit care recent year volum digit web base inform util modern comput base technolog data storag process analysi grown rapid human process limit number variabl given time thus delug clinic use inform intens care unit environ remain untap innov machin learn technolog develop deep neural network effici cost effect data archiv system provid infrastructur appli artifici intellig big data determin clinic event outcom introduc comput base technolog test across domain

D001185;D000077558

T090;T170;T073;T066

36,333,033

physiolog monitor patient acut brain injuri multimod approach neurocrit care manag acut brain injuri abi focus identif prevent manag secondari brain injuri sbi physiolog monitor brain organ system role predict patient recoveri deterior guid individu therapeut intervent measur respons treatment goal improv patient outcom review detail specif physiolog marker brain injuri neuromonitor tool integr use abi patient develop therapeut approach prevent sbi

D003422;D001930

T058;T037

36,333,032

brain deathdeath neurolog criteria intern standard world brain death project articl review criteria determin brain death discuss import protocol develop review intern effort standard clinic test

D001926

T046

36,333,031

neuropharmacolog intens care unit clinician must individu pharmacotherapi patient acut neurolog injuri base multipl factor includ age comorbid chronic medic use mani pharmacokinet pharmacodynam properti alter acut ill particular absorpt distribut metabol elimin may result loss drug effect toxic articl provid clinician general pharmacolog knowledg follow drug regimen common prescrib neurocrit ill adult sedat analges osmotherapi antiseizur medic antishiv agent vasoact agent antithrombot revers agent

D009480;D007362

T091;T093;T073

36,333,029

neurocrit care general intens care unit neurolog condit often encount general intens care unit articl discuss common neurolog issu encount provid guidanc assess manag condit

D007362;D009422

T047;T073;T093

36,333,028

neuroprognost patient sever acut brain injuri left incapacit critic ill unabl make medic decis surrog decis maker must make life death decis patient reli clinician prognost guidanc guidelin current exist guid clinician prognost henc neuroprognost still consid art leav room high variabl review examin current literatur prognost neurocrit care identifi ongo challeng exist field provid suggest futur research goal amelior variabl focus scientif patient center rather artist approach prognost

D016638;D003657

T047;T041

36,333,027

neuromuscular weak intens care diseas peripher nervous system creat addit diagnost conundrum within intens care set caus vast present myriad symptom often ill defin misidentifi care benefit multidisciplinari approach includ neuromuscular specialist rehabilit servic specialti pharmacist addit neurocrit care team general survivor achiev good function recoveri relat preintens care unit baselin

D009468

T019;T047

36,333,026

neurotrauma intracrani pressur manag although intracrani pressur icp monitor mainstay traumat brain injuri tbi manag decad new understand tbi physiopatholog call paradigm shift complex tbi manag preclud icp taken isol valu specif threshold multimod monitor crucial expand comprehens individu pathophysiolog allow precis tailor treatment approach articl review key concept interpret appli publish icp manag guidelin statement

D007427;D000070642

T037;T042

36,333,025

histori neurocrit care subspecialti role neurointensivist subspecialist cement modern medicin global forg collabor neurologist neurosurgeon internist anesthesiologist general surgeon emerg medicin physician pediatrician critic care area requir multiprofession environ neurocrit care har knowledg technolog resourc research opportun embrac multisystem approach care neurolog critic ill although recent formal recogn crucial role serv patient acut life threaten neurolog insult well establish

D003422

T058

36,333,017

ischem stroke patient malign approxim one quarter one third patient ischem stroke embol stroke undetermin sourc esus estim patient esus activ cancer diagnosi presenc cancer potenti increas risk acut ischem stroke various mechan cancer relat hypercoagul intracrani tumor lead arteri compress intracardiac tumor lead cardioembol certain cancer therapeut also contribut risk ischem stroke multipl vascular lesion involv bilater anterior posterior circul high plasma dimer level elev inflammatori marker might suggest cancer relat ischem stroke patient ischem stroke relat malign also higher risk stroke recurr earli neurolog deterior mortal cancer screen acut ischem stroke patient consid etiolog stroke establish clinic histori tobacco use unexplain constitut symptom fever night sweat unexplain weight loss suggest under malign select antithrombot secondari stroke prevent remain controversi clinic trial data use antiplatelet therapi vs anticoagul esus cancer patient limit futur clinic trial specif focus patient ischem stroke relat malign need guid appropri therapeut agent select

D000083242;D020766;D020521;D009369

T047;T191

36,333,015

clinician adopt artifici intellig algorithm detect left ventricular systol dysfunct primari care compar clinician characterist high adopt low adopt artifici intellig ai enabl electrocardiogram ecg algorithm alert possibl low left ventricular eject fraction ef subsequ effect detect patient low ef

D001185;D018487

T090;T046;T073;T066

36,333,014

plant base diet caus cardiovascular mortal nationwid cohort spain enrica studi investig associ health plant base diet index hpdi unhealth plant base diet index updi caus cardiovascular diseas cvd mortal spanish adult

D014676;D002318

T061;T033;T047

36,333,004

target environment risk prevent rheumat diseas target environment factor import way reduc incid rheumat diseas rds approach may popul level furthermor emerg abil identifi individu high risk develop futur rd allow person approach environment modif prevent articl discuss challeng opportun target environment factor prevent rds

D012216

T047

36,333,003

environment risk factor osteoarthr impact individu knee joint injuri osteoarthr debilit chronic condit involv joint degener impact million peopl worldwid place high social econom burden societi knee common joint impact osteoarthr common caus osteoarthr traumat joint injuri specif injuri anterior cruciat ligament purpos review detail non modifi modifi risk factor osteoarthr particular focus individu anterior cruciat ligament injuri read health care provid better comprehend wide varieti factor link osteoarthr

D020370;D007718;D000070598

T047;T037

36,333,002

environment trigger hyperuricemia gout gout preval type inflammatori arthriti worldwid environment factor contribut hyperuricemia risk gout flare caus hyperuricemia includ increas purin consumpt meat alcohol high fructos corn syrup well medic cyclosporin low dose aspirin diuret trigger gout flare includ increas purin consumpt medic use urat lower therapi diuret environment exposur includ lead exposur particul matter exposur temperatur fluctuat physiolog stress found trigger flare right clinic scenario factor consid treat gout patient

D006073;D033461

T047

36,333,001

environment trigger vascul system vasculitid autoimmun diseas character vascular inflamm type vascul thought result antigen exposur genet suscept individu suggest like role environment trigger condit season geograph variat incid provid insight potenti role environment exposur diseas mani data support infecti trigger vasculitid wherea studi identifi noninfecti trigger airborn pollut silica smoke heavi metal review known suspect environment trigger giant cell arter takayasu arter polyarter nodosa kawasaki diseas antineutrophil cytoplasm antibodi associ vascul

D010488;D001327;D056648;D013700;D013625

T047

36,333,000

environment risk inflammatori myopathi date review extern environment factor adult onset idiopath inflammatori myopathi iim environment factor suggest evid includ ultraviolet radiat smoke infecti agent virus particular pollut medic ie statin vitamin defici discuss also discuss potenti implic environment factor iim develop identifi current challeng provid insight futur investig

D014466;D009220

T047;T070

36,332,999

environment risk system sclerosi increas bodi literatur suggest relationship environment factor develop system sclerosi ssc includ occup exposur chemic materi medic alter microbiom dysbiosi environment exposur may impact epigenet regul therebi trigger aberr immun respons result clinic serolog phenotyp diagnos ssc screen studi putat trigger improv understand pathogenesi ssc also inform institut protect measur

D012595;D016273

T047;T037

36,332,998

system lupus erythematosus risk role environment factor system lupus erythematosus sle complex chronic autoimmun diseas etiolog sle multifactori includ potenti environment trigger may occur sequenti multi hit hypothesi review focus sle risk potenti associ environment factor includ infect microbiom diet respir exposur eg crystallin silica smoke air pollut organ pollut heavi metal ultraviolet radiat

D004781;D008180

T047;T037

36,332,997

environment risk spondyloarthropathi spondyloarthropathi also known spondyloarthr encompass spectrum diseas classifi axial peripher musculoskelet manifest extra articular featur common spa make system rheumatolog diseas involv skin eye gut organ systemsresearch identifi risk factor develop spondyloarthr particular regard genet suscept strong associ hla b multipl studi elucid clinic risk factor associ spa diseas activ sever review aim explor environment risk factor spondyloarthr

D025242;D025241;D013167

T047

36,332,996

lifestyl hormon metabol environment risk rheumatoid arthriti although substanti bodi literatur focus understand noninhal risk factor rheumatoid arthriti data mix often conflict given health benefit certain lifestyl modif seem reason clinician promot healthi lifestyl habit relat diet exercis mainten health weight mainten good dental hygien overal howev lifestyl modif may expect modest benefit strategi prevent rheumatoid arthriti high risk patient need

D008019;D001172

T047;T054

36,332,995

inhal addit mucos relat environment risk rheumatoid arthriti rheumatoid arthriti ra occur result complex interplay environment factor genet suscept individu consider evid lung may serv initi site toler loss generat ra relat autoimmun sever environment inhal exposur lung diseas associ ra risk addit evid immun microbi dysregul mucos site includ oral gastrointestin mucosa may contribut develop ra epidemiolog evid link mucos exposur various environment insult risk determin ra review

D001172

T047

36,332,994

epidemiolog opportun challeng studi environment risk factor rheumat diseas rheumat diseas stronger environment hereditari etiolog articl summar key environment risk factor rheumat diseas data sourc generat find key pitfal exist research everi rheumatolog clinician know emerg research opportun hold promis revolution field soon

D012216;D012219

T047;T091

36,332,966

adolesc profession experi metabol bariatr surgeri requir preoper postop support mhealth qualit studi studi aim explor adolesc profession incent experi metabol bariatr surgeri mbs explor perceiv need requir preoper postop support mhealth intervent improv long term healthi lifestyl behaviour health outcom

D017216;D050110

T061;T058

36,332,965

common mental disord associ factor among high school student debr marko town northwest ethiopia institut base cross section studi common mental disord includ anxieti depress somat symptom pose signific public health problem serious effect person well social occup function also affect health qualiti life peopl adolesc age group vulner differ factor accord american psychiatri associ adolesc fulfil criteria least one common mental disord despit high burden disord limit studi ethiopia therefor studi provid preval common mental disord among student ethiopia

D011788;D001523

T078;T048

36,332,964

investig associ il antagonist therapi blood coagul critic ill patient covid protocol prospect observ multicentr studi hypercoagul one main featur covid induc hyperinflammatori respons shift balanc haemostasi toward pro coagul interleukin il antagonist therapi recommend certain subgroup critic ill patient covid modul inflammatori respons interact immun respons haemostasi well recognis therefor object evalu whether modul inflammatori respons il antagonist inflict chang whole blood coagul assess viscoelast method critic ill patient covid

D000086382

T047;T067

36,332,963

global map exercis intervent among covid survivor protocol scope review covid pandem pose unparallel threat dimens human health well pan american health organ acknowledg crucial role rehabilit therapi covid emphasis import exercis programm covid survivor scope review outlin strategi systemat review publish unpublish literatur investig volum evid exercis intervent covid survivor

D000086382

T047;T067

36,332,962

preval harm tradit practic pregnanc associ factor southwest ethiopia communiti base cross section studi assess preval harm tradit practic pregnanc associ factor southwest ethiopia

D011295;D037841

T058;T098

36,332,961

factor associ adolesc sexual experi base biopsychosoci model cross section studi use korea youth risk behavior web base survey kyrb sexual activ import integr behaviour interact biolog psycholog social factor among various chang adolesc howev start sex earli age associ advers outcom thus studi aim investig factor associ adolesc sexual experi base biopsychosoci model

D012309;D000294

T055

36,332,960

opioid prescript usag surgeri opera protocol prospect multicentr observ cohort studi opioid use surgeri postop pain common frequent address opioid analgesia practic must balanc benefit achiev adequ pain relief harm advers effect opioid induc ventilatori impair opioid use disord student traine led collabor studi aim investig compar prescript versus consumpt opioid day postdischarg common surgic procedur impact patient report outcom regard postop pain

D000701;D009293

T121;T048;T131;T109

36,332,959

impact multifacet intervent physician knowledg attitud practic relat pharmaceut incentivis protocol randomis control trial set privat sector constitut larger part health system profit gather take primaci patient well interact pharmaceut compani privat general practition gps experi conflict interest coi situat wherebi imparti gps profession decis make may influenc secondari interest financi gain prescrib specif pharmaceut brand

D001291;D058005

T097;T041

36,332,958

danc manag qualit studi explor perspect person knee osteoarthr type diabet mellitus impact osteoarthr diabet manag daili life type diabet tdm knee osteoarthr oa common co occur epidemiolog studi suggest concomit symptomat knee oa increas risk tdm complic sought explor experi perspect individu live symptomat knee oa tdm focus impact oa tdm manag daili life

D020370;D003924

T047

36,332,957

use microsimul method assess dynam smoke status gain life expect quit longitudin cohort us older adult previous studi unabl estim dynam smoke status us elder general popul studi assess benefit quit term result gain life expect propos novel method estim per cent quit remain lifetim success quit relaps well life expect particip baselin smoke status

D006278;D016540

T089;T055;T064

36,332,956

patient experi codesign rehabilit intervent hospit rapid review codesign strengthen partnership healthcar worker patient also facilit collabor support develop design deliveri healthcar servic prior rehabilit review focus main clinic organis outcom codesign less focus live experi rehabilit patient

D006282;D006761

T093;T073;T097

36,332,955

factor influenc receipt antibiot prescript among insur patient tanzania cross section studi limit data factor influenc antibiot prescript among insur patient assess correl antibiot prescript among insur patient

D000900;D012141

T121;T047;T195

36,332,954

traumat stress symptom famili caregiv patient acut leukaemia protocol multisit mix method longitudin observ studi diagnosi progress recurr cancer often high traumat famili caregiv fcs systemat assess distress approach prevent treatment lack acut leukaemia al life threaten cancer blood often present acut requir intens treatment associ sever physic symptom consequ traumat stress may common fcs patient al aim determin preval sever longitudin cours predictor traumat stress symptom fcs patient al first year diagnosi understand live experi traumat stress perceiv support need

D009369;D007938

T191

36,332,953

mprep studi protocol prospect cohort studi assess feasibl accept hiv pre exposur prophylaxi prep strategi male client femal sex worker kisumu kenya male client mcs integr sex work driven hiv transmiss dynam sexual partner femal sex worker fsw mcs contribut disproportion incid hiv global sub saharan africa new infect attribut mcs fsw partner key popul gap coverag hiv test prevent servic men includ mcs well document yet research innov intervent improv mc uptak effect prevent servic includ pre exposur prophylaxi prep scarc

D065129;D060386;D019380;D015658

T061;T121;T098;T097;T047

36,332,952

effect mind base stress reduct adult sleep disturb updat systemat review meta analysi mind base stress reduct mbsr medit base therapi origin recommend stress manag howev current use allevi sleep disturb therefor contemporari systemat review aim elucid clinic effect mbsr sleep qualiti sleep relat daytim impair adult sleep disturb includ chronic insomnia disord

D064866;D007319;D012893;D009369

T184;T191;T047;T041;T048

36,332,951

declar interest work cross section studi declar interest healthcar practic scotland england understand arrang healthcar organis declar staff interest scotland england context current recommend

D013222;D006282

T064;T097

36,332,950

compar efficaci complic long act intermedi act insulin regimen adult type diabet individu patient data network meta analysi examin compar efficaci complic long act intermedi act insulin differ patient characterist type diabet mellitus tdm

D003922;D007003

T047

36,332,949

risk cardiovascular event lead hospitalis streptococcus pneumonia infect retrospect cohort life studi elucid risk cardiovascular event occurr follow streptococcus pneumonia infect

D001281;D020521;D006333;D003327;D011008

T047;T046

36,332,948

mortal indic qualiti neurosurg care england retrospect cohort studi postop mortal wide use qualiti indic may unreli procedur number andor mortal rate low due insuffici statist power object investig statist valid postop day mortal qualiti metric neurosurg practic across healthcar provid

D017558;D019635

T061

36,332,947

number type neurolog emerg england influenc socioeconom depriv retrospect analysi hospit episod statist data first larg scale analysi neurolog emerg admiss england determin number type emerg admiss neurolog emerg diagnost code mani care neurologist neurosurgeon admiss vari level depriv

D004630;D004827

T033;T047;T046

36,332,946

radiofrequ assist transect pancrea versus stapler distal pancreatectomi studi protocol multicentr randomis clinic trial transpair date pancreat stump closur techniqu shown superior distal pancreatectomi although sever studi shown trend toward better result transect use radiofrequ devic radiofrequ assist transect rft randomis trial purpos perform date therefor design randomis clinic trial hypothesi techniqu use distal pancreatectomi superior reduc clinic relev postop pancreat fistula cr popf mechan closur

D010180;D011788

T061;T078

36,332,945

protocol systemat review effect patient posit rapid sequenc intub rapid sequenc intub rsi advanc airway techniqu perform endotrach intub patient high risk aspir although rsi recognis life save techniqu perform mani physician various set emerg depart intens care unit still lack consensus various featur procedur notabl patient posit previous expert comment uniqu drawback benefit various posit studi publish compar patient posit affect endotrach intub context rsi purpos systemat review compil exist evid understand compar differ patient posit potenti affect success rsi

D007442;D000079603

T061

36,332,944

navig youth mental health addict protocol realist review synthesi approach practic navmap standard project mental health andor addict mha concern affect approxim million children youth canada yet less receiv appropri treatment concern youth receiv appropri support may disengag care may experi last mha issu famili youth also support find access care thus system support need help youth famili find equit access appropri care navig innov mha care provid patient centr support care plan help individu famili overcom barrier care despit increas avail navig servic youth mha concern practic model vari singl sourc synthesis evid regard approach outcom popul comprehens standard

D008605;D016739

T058;T048

36,332,942

develop algorithm determin heart failur reduc preserv eject fraction use nationwid electron healthcar record uk determin heart failur hf phenotyp routin electron health record ehr challeng aim develop valid ehr algorithm identif specif hf phenotyp use read code combin select patient characterist

D006333

T047;T046

36,332,941

develop contemporari communiti clinic patient heart failur preserv eject fraction within current nation health servic model diagnost therapeut arsenal heart failur preserv eject hfpef expand novel therapi eg sodium glucos co transport inhibitor firmer recommend optimis non cardiac comorbid unclear outpati hfpef model adequ deliv therefor evalu efficaci exist dedic hfpef clinic find innov way design comprehens model tailor modern era hfpef

D006333;D000086382

T047;T046;T067

36,332,939

free educ materi eular school rheumatolog websit lot educ content includ free educ materi interest rheumat musculoskelet diseas rmds eular school rheumatolog esor websit easi access three click take straight content need search esor web browser click catalog click free learn materi choos need one click particular eular imag librari eular learn materi ra give lot imag slide help present eular long histori provid educ rheumatologist health profession rheumatolog peopl rmds commit educ enshrin eular strategi alway larg part eular

D012219;D001172;D009140

T047;T091

36,332,938

peripher spondyloarthr psoriat arthriti sine psorias deal semant clinic meaning differ diagnos peripher spondyloarthr pspa remain signific challeng due lack specif diseas biomark overlap spa subtyp main psoriat arthriti psa repres diagnost challeng particular absenc skin psoriasi psa sine psorias narrat review aim compar epidemiolog genet suscept pathophysiolog classif criteria diseas phenotyp burden therapeut guidelin patient diagnos pspa psa sine psorias determin two entiti consid joint distinct global pspa appear inclus compar psa sine psorias area similar includ age onset number joint involv preval axial involv howev patient pspa male gender predomin higher preval hla b enthes involv larg joint lower limb wherea patient psa sine psorias higher preval hla cw dactyl involv hand distal interphalang joint therefor differ pspa psa sine psorias goe beyond semant dissimilar drive scientif effort reach better characteris pspa individu diseas accord randomis clinic trial target patient well defin pspa identifi effect therapi popul

D015535;D025241;D011565

T047

36,332,937

improv pregnanc counsel contracept counsel document singl rheumatolog academ practic qualiti improv project purpos qualiti improv project improv rate pregnanc counsel document regard risk teratogen medic includ leflunomid mycophenol methotrex cyclophosphamid women childbear age year goal increas document rate month first perform emr chart review women seen month prior intervent faculti singl rheumatolog academ centr determin mani women document contracept pregnanc counsel includ written document anywher note icd code specif pregnanc counsel contracept counsel intervent implement percentag women document pregnanc counsel chang preintervent postintervent preintervent women receiv document pregnanc counsel postintervent women receiv document pregnanc counsel percentag women document contracept counsel howev chang preintervent postintervent preintervent women receiv document contracept counsel postintervent women receiv document contracept counsel improv

D058996;D012219

T091;T057

36,332,936

awhonn postpartum discharg educ patient knowledg sustain object evalu whether implement associ women health obstetr neonat nurs awhonn postpartum discharg educ initi associ improv patient knowledg warn sign sever matern morbid smm initi self sustain

D010351;D049590

T101;T058;T079

36,332,934

hilar tuberculosi versus klatskin tumour diagnost challeng hepatobiliari tuberculosi rare condit caus obstruct jaundic either enlarg lymph node around bile duct involv biliari epithelium tubercul process sinc tissu diagnosi mandatori proceed resect initi liver transplant protocol benign lesion occasion misdiagnos hilar cholangiocarcinoma present case hepatobiliari tuberculosi present obstruct jaundic due hilar obstruct mass caus obstruct later found pseudotumour typic tuberculosi diagnosi meant extens surgic resect protocol cholangiocarcinoma avoid patient recov complet cours antitubercular therapi

D018285;D041781;D001650;D018281;D014376

T047;T191

36,332,932

spindl cell sarcomatoid tumour trachea rare primari malign tumour spindl cell carcinoma subtyp sarcomatoid carcinoma previous describ various anatom locat though rare tracheaw present case woman present sore throat stridor fibreopt nasendoscopi demonstr tracheal mass occupi airway cricoid cartilag third tracheal ring infiltr thyroid gland subsequ ct demonstr pulmonari emboli vertebr metastasi biopsi infiltr thyroid confirm diagnosi spindl cell carcinoma length tumour metastasi present made surgic unresect refer palliat stent die acut deteriorationthi patholog report five time previous literatur manag strategi vari great patient primari tracheal tumour difficult manag due rariti clear guidelin

D014134;D012509;D002277;D012983;D013964

T191

36,332,931

diagnosi system lupus erythematosus earli manifest eosinophil pleural effus woman histori crohn diseas present emerg depart dyspnoea cough intermitt fever evalu reveal pleural effus neutrophil predomin initi suspicion infect prompt short cours antibiot therapi howev patient subsequ develop recurr pleural effus eosinophil predomin serolog data confirm diagnosi system lupus erythematosus sle patient start appropri treatmentthi case present initi manifest eosinophil domin pleural effus sle current guidelin treat pleural effus explor rheumatolog caus howev believ case demonstr valu prompt investig rheumatolog aetiolog otherwis unclassifi eosinophil predomin pleural effus investig includ serolog data import confirmatori marker diagnosi sle

D010996;D008180;D012216

T047

36,332,928

improv access medicin lesson year drug reform china china initi healthcar reform provid access afford healthcar summaris china drug reform use framework china initi comprehens drug polici address differ issu includ issu amend major regul chang institut set implement market authoris holder system bioequival assess improv qualiti drug leverag acceler market approv insur list encourag need driven innov improv access new drug introduc compulsori licens address major public health threat need scale nation essenti medicin polici introduc pharmacoeconom evalu nation reimburs drug list promot ration use medicin evid base select appli differenti price strategi scale zero mark polici form new financ mechan adapt bulk procur place strict regul suppli chain manag ensur suppli reduc cost empow pharmacist improv ration use medicin use procur suppli chain digit platform inform decis improv effici china drug reform adopt phase system approach mobilis multipl polici lever includ govern regul financ despit progress emerg challeng implement coordin capac need address cross cut lesson china drug reform includ align drug reform overal health reform adapt system approach mobilis polici lever stakehold inform polici decis conduct pilot studi

D018166;D018954

T121;T064

36,332,927

mer tyrosin kinas novel suscept gene sle relat end stage renal diseas lupus nephriti ln common sever manifest sle genet risk nephriti progress end stage renal diseas esrd patient ln remain unclear herein aim identifi novel genet associ ln focus subphenotyp esrd

D008180;D008181;D007676

T047

36,332,660

model growth divers microorgan feast famin enrich polyhydroxyalkano phas biodegrad polym decreas sever environment pollut petroleum plastic pha product mix microbi communiti extens studi lower high pha price howev competit distinct microbi communiti enrich pha accumul mix cultur wide investig thus work develop mathemat model competit pha accumul non pha accumul feast famin enrich strategi develop model success simul publish lab scale experiment data plasticicumulan acidivoran well studi pha accumul store pha cell weight growth kinet pha non pha accumul estim compar valu literatur uncertainti model kinet studi expand model includ addit sub biomass compon heterotroph group result microbi divers microbi communiti observ influenc enrich pha accumul mix cultur addit calibr model appli investig cultiv condit cycl length carbon nitrogen ratio solid retent time success p acidivoran enrich mix cultur develop model appli control cultiv enrich pha accumul larg scale pha product system practition point new model enrich pha accumul develop model simul pha accumul enrich cultur model calibr valid plasticicumulan acidivoran impact microbi divers enrich pha accumul investig short cycl h srt suggest success enrich

D054813;D020563

T007;T109

36,332,654

project outcom univers test treatment generalis hiv epidem zambia south africa hptn popart trial model studi long term impact univers home base test treatment part univers test treatment utt hiv incid unknown made project use detail individu base model effect intervent deliv hptn popart cluster randomis trial

D015658;D058872

T047;T067

36,332,653

impact univers test treatment sexual risk behaviour herp simplex virus type prespecifi secondari outcom analysi hptn popart communiti randomis trial comprehens hiv prevent strategi rais concern knowledg intervent reduc risk hiv infect might mitig individu percept risk result riskier sexual behaviour investig prespecifi secondari outcom hptn popart trial determin whether combin hiv prevent strategi includ univers hiv test treatment chang sexual behaviour specif investig whether evid sexual risk compens

D015658

T047

36,332,652

viral suppress self report art adher year univers test treatment hptn popart communiti randomis trial zambia south africa cross section analysi unaid set target individu antiretrovir therapi art viral suppress use data hptn popart trial report whether introduct univers test treatment affect viral suppress treatment adher among individu self report take art identifi risk factor outcom

D015658;D019380

T121;T047

36,332,611

shariant platform enabl evid share across australian clinic genet test laboratori support variant interpret share genom variant interpret across laboratori promot consist variant assert landscap analysi australian clinic genet test laboratori identifi despit nation accredit bodi recommend encourag laboratori submit genotyp data clinic databas fewer variant share clinvar public databas consult australian laboratori identifi resourc constraint limit routin applic manual process consent issu differ interpret system barrier share inform use defin key need solut requir enabl nation share variant interpret shariant platform use grch grch genom build develop enabl ongo share variant interpret associ evid australian clinic genet test laboratori possibl two way autom share implement disrupt laboratori workflow would minim term use develop consult current restrict access australian clinic genet test laboratori shariant design store compar structur evid promot record resolut inter laboratori classif discrep streamlin submiss variant assert clinvar decemb larg prospect curat variant record particip laboratori share discrep classif identifi variant submit one laboratori demonstr co design clinic laboratori vital develop implement nation variant interpret share effort approach improv inter laboratori concord enabl opportun standard interpret practic

D030541;D007753

T170;T073;T093

36,332,610

carerar canada outcom decad network scienc rare diseas gene discoveri past decad wit rapid evolut rare diseas rd research fuel avail genom wide exom genom sequenc transform technolog introduc research communiti carerar canada consortium launch initi forg follow carerar carerar solv amount three era diagnosi discoveri carerar consortium use exom sequenc recent genom omic technolog identifi molecular caus unsolv rds achiev diagnost yield particip famili includ discoveri deleteri variant gene previous associ diseas continu studi candid variant novel gene famili consortium made signific contribut rd research includ develop platform data collect share instig canadian network catalyz function character research novel gene consortium instrument implement genom wide sequenc public fund test rd diagnosi canada despit success past decad challeng solv rds remain enorm work far must leverag clinic omic data secondari use develop tool polici support safe data share continu explor util new emerg technolog optim research protocol delin complex diseas mechan success approach realm requir offer diagnost clariti famili rds

D035583;D059472

T047;T028

36,332,609

pull wool pathogen eye llama nanobodi inhibitor bacteri sos respons issu structur maso et al discov nanobodi inhibit sos respons escherichia coli target lexa repressor proteas high resolut structur novel lexa nanobodi complex reveal function stabil lexa inact conform prevent co proteolysi reca

D013014;D002161

T045;T015

36,332,608

trap tribbl nanobodi assist structur trib pseudokinas trib member human tribbl pseudokinas famili function molecular scaffold divers signal pathway issu structur jamieson et al report first high resolut structur trib bound nanobodi offer insight activ like state

D017871;D047908

T123;T126;T116

36,332,607

hit hurt pantothen kinas target pathogen fungi issu structur gihaz colleagu develop antifung compound target fungal pantothen kinas pank util high throughput chemic screen along biochem function analys newli solv fungal pank crystal structur high affin inhibitor produc invalu insight mechan fungal pank gain

D017853;D057166

T059;T126;T116

36,332,606

structur function basi mammalian microrna biogenesi dicer microrna mirna rna interfer rnai pathway reli small rnas produc dicer endonucleas mammalian dicer primarili support essenti gene regul mirna pathway specif adapt mirna biogenesi unknown show adapt entail uniqu structur role dicer dexdh helicas domain although mice toler loss putat atpas function complet absenc domain lethal assur high fidel mirna biogenesi structur murin dicer mirna precursor complex reveal dexdh domain helicas unrel structur function lock dicer close state facilit mirna precursor select transit cleavag compet open state stimul dicer bind protein tarbp absenc dexdh domain mutat unlock close state reduc substrat select activ rnai thus dexdh domain structur contribut mammalian mirna biogenesi under mechanist partit mirna rnai pathway

D043244;D035683

T123;T126;T116;T114

36,332,605

lncrna cctt mediat rna dna rna protein interact facilit recruit cenp c centromer dna kinetochor assembl kinetochor assembl centromer central chromosom segreg defect process caus mitot error aneuploidi besid well establish protein network emerg evid suggest involv regulatori rna kinetochor assembl howev remain elus ident rna let alon mechan action critic process report cctt previous uncharacter long non code rna lncrna transcrib arm human chromosom play vital role kinetochor assembl show cctt high local centromer via format rna dna triplex specif interact cenp c help engag blueprint protein centromer consequ cctt loss trigger extens mitot error aneuploidi find uncov non centromer deriv lncrna recruit cenp c centromer shed critic light function centromer dna sequenc anchor point kinetochor assembl

D062085

T123;T114

36,332,604

crispr assist transposit tnsc find thread needl haystack hoffmann et al demonstr rna guid transposon remark sequenc specif due action aaa atpas tnsc recruit transposas correct target site

D029968

T116

36,332,603

context key modul protein multival diseas issu molecular cell song et al demonstr mutat yeat domain enl aberr activ gene express form condens specif genom loci use divers experiment approach author dissect molecular underpin enl mutant condens format

D035602;D014157

T123;T116

36,332,602

terra radap r loop depart alt telomer issu molecular cell kaminski et al yadav et al demonstr radap terra non code rna posit regul altern mechan telomer mainten promot loop format chromatin direct mechan suppress transcript collis event alt telomer synthesi

D059505;D062085

T045;T123;T114;T043

36,332,601

introduc new group leader devin schwepp talk devin schwepp set group univers washington studi quantit mass spectrometri base proteom field constant evolv overcom self doubt go gut hire hope build environ excel inclus trust alway encourag lab member keep ask

D035502;D010560

T054;T057

36,332,572

singl cell transcriptom atlas glial divers human hippocampus across postnat lifespan molecular divers glia human hippocampus tempor dynam lifespan remain larg unknown perform singl nucleus rna sequenc generat transcriptom atlas human hippocampus across postnat lifespan detail analys astrocyt oligodendrocyt lineag microglia identifi subpopul distinct molecular signatur reveal associ specif physiolog function age depend chang abund diseas relev character spatiotempor heterogen gfap enrich astrocyt subpopul hippocamp format use immunohistolog leverag glial subpopul classif refer map reveal divers glia differenti human pluripot stem cell identifi dysregul gene patholog process specif glial subpopul alzheim diseas ad togeth studi signific extend understand human glial divers popul dynam across postnat lifespan dysregul ad provid refer atlas stem cell base glial differenti

D059467;D000544

T081;T047;T048;T086

36,332,571

spatial dynam metabolom identifi metabol cell fate trajectori human kidney differenti accumul evid demonstr import role metabol cell fate determin howev challeng assess metabol spatial resolut acknowledg heterogen cellular dynam tissu microenviron use multi omic platform studi cell type specif dynam metabol complex tissu describ metabol trajectori nephrogenesi develop human kidney exploit situ analysi isotop label shift glycolysi toward fatti acid oxid observ differenti renal vesicl toward shape bodi proxim tubul addit show hipsc deriv kidney organoid character metabol immatur phenotyp fail use mitochondri long chain fatti acid energi metabol furthermor supplement butyr enhanc tubular epitheli differenti matur cultur kidney organoid find highlight relev understand metabol trajectori effici guid stem cell differenti

D057026

T025

36,332,570

uncov emerg hscs human fetal bone marrow singl cell rna seq analysi fetal develop human hematopoiet stem cell hscs colon bone marrow bm self renew sustain hematopoiesi throughout life howev precis timepoint hscs seed bm unclear use singl cell rna sequenc map transcriptom landscap human fetal bm spleen hematopoiet stemprogenitor cell hspcs microenviron post concept week pcws demonstr function hscs capabl reconstitut long term multi lineag hematopoiesi adult nog mice emerg bm pcws contrast function hscs detect spleen pcws compar nich hspc interact bm spleen identifi ligand receptor pair like involv fetal hsc migrat mainten work pave way research mechan under hsc colon human fetal bm provid invalu resourc futur studi hsc develop

D001853;D006412

T023;T025;T024

36,332,569

reciproc regul mesenchym stem cell immun respons mesenchym stemstrom cell mscs exist almost tissu particip tissu regener homeostasi vitro expand mscs employ therapeut autoimmun diseas organ failur mani chronic disord remark repar homeostat mainten function mscs reli interact inflammatori microenviron discuss characterist function mscs differ pathophysiolog condit highlight immunomodulatori function mscs alter accord inflammatori cue hope provid new insight divers immunoregulatori properti mscs tissu regener therapi

D059630;D001327;D045164

T061;T047;T025

36,332,568

vade mecom peel back layer hematopoiesi recent studi demonstr hematopoiet stem cell hscs contribut minim blood immun cell product develop becom activ postnat work also reveal mecom express use distinguish rare hscs abund progenitor aris maintain embryon hematopoiesi

D006410;D006412

T025;T042

36,332,567

function renal collect duct human pscs collect duct kidney control balanc water electrolyt well ph urin maintain bodi homeostasi shi et al recent report natur biotechnolog protocol generat function collect duct cell human pluripot stem cell

D007685

T023

36,332,566

glioblastoma stem cell histarion glioblastoma lethal malign possess rapid evolv microenviron contain necrotichypox area aberr microvasculatur glioblastoma stem cell gscs promot tumor growth recurr treatment resist chen et al find gscs drive integr epigenet metabol control angiogenesi via histamin propos antihistamin potenti therapi

D005909;D001932

T191

36,332,522

user satisfact readi use e health applic futur polish societi earli phase covid pandem cross section studi covid pandem result rapid expans e health servic poland main aim studi assess determin user satisfact readi use e health applic polish societi

D000086382;D057220;D017216

T041;T047;T058;T067

36,332,521

compet framework phd program health inform manag job expect profession compet requir health inform manag studentsgradu constant chang workforc develop requir curricula line new emerg compet although compet framework field one specif phd educ program aim develop compet framework phd program iran

D008490;D063025

T091;T066;T057

36,332,520

polici regul data share cohort via data infrastructur interview studi fund agenc platform construct stimul cohort data share nevertheless mani polici barrier imped data share various intervent propos address barrier includ incent creation data share mandat research

D057766;D033181

T170;T052;T054

36,332,519

creation core compet framework clinic informat genesi maintain relev unit kingdom faculti clinic informat fci embark creation core compet framework respons need provid support work clinic health social care also hold informat role

D008490

T091;T066

36,332,365

mild acut kidney injuri pediatr surgeri associ long term renal dysfunct retrospect cohort studi acut kidney injuri aki sudden deterior renal function common pediatr patient undergo cardiac non cardiac surgeri studi investig associ postop aki kidney dysfunct seen long term advers outcom pediatr patient studi aim determin associ postop aki mild aki vs aki mild aki vs moder sever aki chronic kidney dysfunct ckd seen long term pediatr patient undergo cardiac non cardiac major surgeri

D058186;D051436

T047;T037

36,332,358

transform arm joint coordin hand extern coordin explain non uniform precis hand posit sens horizont workspac peopl perceiv hand posit horizont workspac precis radial azimuth direct closer bodi farther away current explan posit sens non uniform includ spatial asymmetri arm propriocept activ andor cortex map experi depend learn arm postur other investig contribut non uniform postur depend transform arm joint angl sens arm proprioceptor hand posit measur precis hand posit sens bimanu hand mirror posit match task four horizont target form squar front bodi blindfold individu found lower hand precis azimuth radial direct higher azimuth precis close target higher radial precis distant target theoret analyz transform random angl error shoulder elbow hand posit random error horizont plane obtain similar distribut hand posit error predict experiment hand precis ellips orient ellips shape size high correl near orthogon arm stiff ellips orient report literatur conclud joint hand coordin transform respons non uniform precis hand posit sens

D001132;D004551

T029;T030

36,332,298

microbi life strategi high rrna operon copi number facilit energi nutrient flux anaerob digest microbi life strategi reflect rrna operon rrn copi number determin microbi ecolog role howev relationship microbi life strategi energi nutrient flux anaerob digest ad remain elus studi investig microbi rrn copi number express ratio use amplicon sequenc rrna gene rrna monitor ch daili product approxim status energi nutrient flux semi continu ad signific posit correl mean rrn copi number microbi communiti digest ch daili product detect control treatment fed swine manur reduc feedstock complex replac part swine manur fructos appl wast weaken correl feedstock complex increas correl strengthen similar result detect mean rrn express ratio microbi communiti respons mean rrn copi number express ratio communiti feedstock addit differ reduc feedstock complex control treatment well digest straw find reveal novel relationship microbi communiti life strategi energi nutrient flux role feedstock characterist therein ad

D012407;D008372

T167;T028

36,332,297

effect free ammonia shock chlorella sp wastewat concentr depend activ respons enhanc settleabl unstabl microbi activ unsatisfactori settl perform imped develop implement microalg wastewat treatment especi high ammonium wastewat presenc free ammonia fa shock fa due nutrient fluctuat wastewat demonstr primari stress factor suppress microalg activ recent studi clear reveal inhibit mechan fa specif high level mgl inhibit genet inform process photosynthesi nutrient metabol howev effect various fa shock concentr microalg activ settl perform remain unknown limit wastewat bioremedi effici improv process develop herein concentr depend shock fa employ microalga exponenti growth stage effect microalg growth photosynthesi observ result show studi five fa shock concentr rang mgl signific inhibit biomass product sharp reduct photosynthesi decreas fvfm valu observ fa concentr mgl hand fa shock enhanc microalg settl effici fold believ due stimul intra extracellular protein content therebi enhanc extracellular polym substanc ep secret specif fa shock induc higher cellular protein content cost decreas carbohydr fatti acid content improv protein secret fold ep product fa shock induc variat intra extracellular biomolecul support regul protein process export assist excess energi generat fatti acid degrad carbohydr consumpt addit fa shock signific decreas biomass nutrit valu indic fold lower essenti amino acid score near reduc essenti non essenti amino acid ratio slight decreas biodiesel qualiti studi expect enrich knowledg microalg activ settl perform respons fluctuant ammonium concentr wastewat promot develop microalg wastewat treatment

D002708;D058086;D064751

T104;T197;T204;T002

36,332,296

applic bipolar membran electrodialysi simultan recoveri high valu acidalkali salin wastewat depth review develop comprehens util high salin wastewat salt resourc regener consid fundament requir process sustain econom benefit one potenti candid bipolar membran electrodialysi bmed rapid develop recent year treatment salin wastewat differ method direct obtain salt condens wastewat bmed could util convert dissolv wast salt higher valu acid alkali simultan various advantag includ outstand environment effect econom benefit review recent applic bmed wast salt recoveri high valu acidalkali generat salin wastewat systemat outlin base summari economi analysi bmed review role desalin resourc recoveri addit bmed base process integr situ util generat acidalkali resourc discuss furthermor influenc oper factor bmed perform outlin final strategi improv bmed perform conclud furthermor futur applic prospect bmed present work would provid guidanc applic bipolar membran electrodialysi salin wastewat treatment high valu convers salt resourc acid alkali

D062065;D018508

T083;T052;T069;T057

36,332,295

nanopor base long read metagenom uncov resistom intrus antibiot resist bacteria treat wastewat receiv water bodi wastewat treatment plant wwtp effluent discharg could induc resistom enrich receiv water environ howev general lack robust antibiot resist bacteria arb identif method drive mechan resistom accumul receiv environ unclear took advantag enhanc arb recognit nanopor long read distinguish indigen arb accumul wwtp born arb receiv water bodi domest wwtp bioinformat framework name argpor https githubcomsustc xylabargpor construct evalu facilit antibiot resist gene arg arb identif nanopor read arg identif argpor show compar precis recal common adopt blastp base method wherea spectrum arb doubl assembl illumina dataset total identifi arb genera carri arg subtyp receiv seawat whose concentr general time higher clean seawat notabl report primari resistom intrus caus reviv residu microb surviv disinfect treatment wwtp born arb includ sever animalhuman enter pathogen contribut receiv water resistom plasmid class integron reckon major vehicl facilit persist dissemin arg moreov work demonstr import extens carrier identif determin drive forc multifactor coupl resistom boom complic environment condit therebi pave way establish prioriti effect arg mitig strategi

D062065;D058608

T083;T069;T082

36,332,272

evalu onlin interprofession simul workshop obstetr neonat emerg explor student percept learn interprofession aspect obstetr neonat emerg onlin simul base workshop

D008880;D013337;D020375

T065;T091;T097

36,332,265

shortcut thermodynam quasistat oper near term quantum technolog requir develop feasibl implement robust strategi control complex mani bodi system end varieti techniqu call shortcut adiabat develop mani shortcut alreadi demonstr power implement distinct scenario yet often also desir addit approxim strategi avail applic larg class system henc letter take inspir thermodynam propos focus macrost rather microst adiabat dynam identifi process preserv equat state systemat correct obtain adiabat perturb theori demonstr approach improv upon fast quasiadiabat drive appli method quantum ise chain transvers field

D001334

T056

36,332,264

edg state local length critic expon surviv probabl topolog waveguid edg state topolog phase transit observ various platform date verif edg state associ topolog invari most studi yet quantit measur topolog phase transit still lack show direct measur edg state local length surviv probabl employ photon waveguid array demonstr topolog phase transit base su schrieffer heeger model measur surviv probabl lattic boundari show long time limit surviv probabl p e loc loc local length length deriv surviv probabl compar distanc transit point yield critic expon phase boundari experi provid altern rout character topolog phase transit extract key physic quantiti

D011336

T081

36,332,249

activ refriger power inertia present oper principl refriger use inerti effect activ brownian particl local reduc kinet temperatur order magnitud environment temperatur principl exploit peculiar far unknown shape phase diagram inerti activ brownian particl initi motil induc phase separ target cool regim remark activ refriger oper without requir isol wall open rout toward use systemat absorb trap eg toxic substanc environ

D012034;D003080

T070;T066

36,332,248

dynam system modul symmetri extend notion multipol subsystem symmetri general spatial modul symmetri uncov two instanc exponenti quasi period modul provid simpl microscop model one two three dimens seek understand effect long time dynam numer studi stochast cellular automaton evolut obey symmetri prove one dimens period modul symmetri lead diffus scale correl modul finit microscop momentum higher dimens symmetri take form line surfac conserv momenta give rise exot form subdiffus behavior rich spatial structur influenc lattic scale featur exponenti modul hand lead correl infinit long live boundari decay exponenti bulk

D004058

T070