PMID
int64 35.7M
36.4M
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36,333,378
|
physic inform machin learn differenti program heterogen underground reservoir pressur manag avoid pressur subsurfac reservoir critic applic like co formula see text sequestr wastewat inject manag pressur control injectionextract challeng complex heterogen subsurfac heterogen typic requir high fidel physic base model make predict co formula see text fate furthermor character heterogen accur fraught parametr uncertainti account heterogen uncertainti make comput intens problem challeng current reservoir simul tackl use differenti program full physic model machin learn determin fluid extract rate prevent pressur critic reservoir locat use dpfehm framework trustworthi physic base standard two point flux finit volum discret also automat differenti like machin learn model physic inform machin learn framework use convolut neural network learn appropri extract rate base permeabl field also perform hyperparamet search improv model accuraci train test scenario execut evalu feasibl use physic inform machin learn manag reservoir pressur construct test suffici accur simul time faster under physic base simul allow near real time analysi robust uncertainti quantif
|
D000069550;D016571
|
T170;T066
|
36,333,377
|
metabolom profil acut liver transplant reject pediatr popul pediatr liver transplant reject affect children current liver biopsi expens invas best method diagnosi discoveri valid clinic biomark blood biospecimen would improv clinic care studi store plasma sampl util two cross section cohort liver transplant patient children healthcar atlanta high resolut metabol profil complet use establish method children n without n acut cellular reject includ analysi n total mean age racial divers cohort rang year reject group year reject group linear regress provid signific differenti metabolit group opl da show metabolit vip total overlap signific metabolit opl da linear regress analys detect pathway analysi p signific metabolit result suggest develop non invas biomark base test possibl reject screen
|
D006084;D016031
|
T061;T042
|
36,333,376
|
kallikrein proteoform reproduct paramet stallion condit climat hors season polyoestr anim photoperiod main factor modul reproduct activ consensus androlog biochem factor influenc breed season assess involv climat reproduct mangalarga marchador stallion monitor year regard semen qualiti semin plasma proteom show kallikrein klks proteoform semin plasma involv climat condit reproduct breed season greater abund differ type klks occur simultan lower sperm motil greater semen volum higher concentr glucos cholesterol consid vasodil due activ kallikrein kinin system consequ inhibit renin angiotensin system may associ lower sperm motil unravel involv klk proteoform reproduct season prioriti hors breed
|
D013081;D055101
|
T059;T043
|
36,333,375
|
hyperbol materi enhanc scatter nanoscopi label free super resolut imag fluoresc super resolut microscopi last two decad extens develop access deep subwavelength nanoscal optic label free super resolut technolog howev achiev slight improv compar diffract limit context demonstr label free imag method ie hyperbol materi enhanc scatter hmes nanoscopi break diffract limit tailor light matter interact specimen hyperbol materi substrat excit high confin evanesc hyperbol polariton mode dark field detect hmes nanoscopi success show high contrast scatter imag spatial resolut around nm consid wavelength nm detect optic numer apertur na object len valu repres fold resolut improv beyond diffract limit hmes provid capabl super resolut imag fluoresc avail challeng appli
|
D008856
|
T059
|
36,333,374
|
updat vaccin protect sar cov variant includ omicron b prevent transmiss hamster current covid vaccin base prototyp spike sequenc ancestr sar cov strain howev ongo pandem fuel variant concern voc escap vaccin mediat protect demonstr immun hamster use prototyp spike express yellow fever yfd vector block ancestr virus b lineag voc alpha b yet fail fulli protect beta b howev yfd vector vaccin candid evolv antigen induc consider improv neutral antibodi respons voc beta gamma p recent predomin omicron b maintain immunogen ancestr virus voc delta b thus vaccin anim resist challeng voc includ vigor high titr exposur difficult cover beta delta omicron variant elimin detect virus mark improv lung patholog final vaccin hamster transmit delta variant non vaccin cage mate overal data illustr current first generat covid vaccin may need updat maintain efficaci emerg voc spread communiti level
|
D014765;D000086382;D022341
|
T129;T121;T116;T067;T047
|
36,333,371
|
potenti explan global increas tropic cyclon rapid intensif tropic cyclon rapid intensif event often caus destruct hurrican landfal associ strongest storm forecast highest error multi decad observ dataset tropic cyclon behavior recent enabl document upward trend tropic cyclon rapid intensif sever basin howev robust anthropogen signal global intensif trend physic driver intensif trend yet identifi address knowledg gap compar observ trend intensif tropic cyclon environment paramet simul natur variabl high resolut global climat model multipl basin global dataset detect signific increas intensif rate posit contribut anthropogen forc furthermor thermodynam environ around tropic cyclon becom favor intensif climat model show anthropogen warm signific increas probabl chang
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D055867
|
T070
|
36,333,369
|
trophic provis parent trade off lead success reproduct perform coral bleach event warm ocean temperatur sever compromis health resili coral reef worldwid coral bleach affect coral physiolog energi avail coral reproduc mechan associ reproduct alloc coral poor understood especi bleach event occur use isotop label techniqu trace acquisit alloc carbon adult gamet autotrophi heterotrophi previous bleach non bleach montipora capitata porit compressa coral experi reveal speci reli autotrophi alloc carbon gamet heterotrophi less reli upon carbon sourc experienc trade less carbon avail adult tissu provis gamet especi previous bleach use differ strategi alloc carbon gamet time capitata alloc carbon gamet despit bleach limit alloc carbon adult tissu less carbon alloc bleach compar non bleach coloni time period p compressa maintain carbon alloc adult tissu alloc carbon gamet studi highlight import autotrophi carbon alloc adult coral gamet speci specif differ carbon alloc depend bleach suscept
|
D037421
|
T204
|
36,333,367
|
preval cerebrovascular accid patient ulcer coliti singl academ health system general ibd increas arterioven thromboembol event though associ uc cerebrovascular complic remain inconclus studi suggest young women uc increas risk cerebrovascular accid cva focus studi character rate anatom distribut risk factor cva patient uc develop retrospect cohort patient uc singl health care system june june neuroimag use document presenc locat type stroke tradit risk factor consid preval cvas patient uc compar general popul minnesota mn unit state us total uc patient identifi femal f uc male uc preval cva uc patient ci higher us p minnesota ci p preval increas sex peak preval ci women uc age older age cancer atrial fibril risk factor cva univari analysi sex multifactori analysi age atrial fibril risk factor cva uc cohort age associ cva f uc common type cva ischem stroke common locat cvas uc patient frontal occipit lobe respect uc patient increas risk cva women demonstr highest risk provid awar risk make treatment decis uc
|
D001281;D003093;D020521
|
T047;T046
|
36,333,366
|
identif mutat sar cov pcr primer region due constant increas number mutat sar cov genom concern emerg possibl decreas diagnost accuraci revers transcript polymeras chain reaction rt pcr gold standard diagnost test sar cov propos analysi pipelin discov genom variat overlap target region common use pcr primer set provid list mutat public avail format base dataset million sar cov sampl approach distinguish among mutat possibl damag impact pcr effici one anticip neutral sens sampl categor prone misclassif vs like correct detect given pcr primer set base estim effect mutat present sampl suscept misclassif general present daili rate lower although particular primer set seem compromis perform detect omicron sampl differ variant strain may temporarili gain domin worldwid sar cov viral popul effici particular pcr primer set may chang time therefor constant monitor variat primer target region high recommend
|
D000086402;D000086382
|
T005;T067;T047
|
36,333,365
|
autom whole slide imag analysi translat quantif liver fibrosi current literatur highlight need precis histolog quantit assess fibrosi achiev convent score system inher discontinu valu reader depend variabl use autom imag analysi softwar measur fibrosi deposit two relev preclin model liver fibrosi establish correl quantit fibrosi descriptor longitudin quantif liver fibrosi carri progress post necrot ccl induc metabol hf cdaa feed model chronic liver diseas mice whole slide imag picrosirius red stain liver section analyz use fulli autom unsupervis softwar fibrosi character signific increas collagen proportion area cpa week ccl hf cdaa progress increas week respect cpa compar collagen content assess biochem hydroxyprolin assay hyp standard histolog stage system cpa show high correl hyp content ccl r hf cdaa r model high correl also found ishak score modifi version r ccl hf cdaa r well nash crn hf cdaa r correl support use autom digit analysi reliabl tool evalu dynam liver fibrosi efficaci antifibrot drug candid preclin model
|
D008103;D008099
|
T047;T023
|
36,333,364
|
random multicent evalu efficaci hyaluron acid versus cyclosporin dri eye syndrom hyaluron acid ha cyclosporin csa eyedrop common prescrib dri eye syndrom des effect prepar des well known yet superior one anoth studi littl assess efficaci toler ha compar combin csa plus carboxymethylcellulos cmc ha plus csa patient moder sever des total patient moder sever des recruit random one three treatment week effect assess baselin week primari endpoint chang corneal stain score secondari endpoint tear break time tbut strip meniscometri sm score ocular surfac diseas index osdi score toler questionnair chang corneal stain score ha baselin non inferior csa corneal stain score tbut sm score osdi score improv group without statist signific intergroup differ better toler lower preval advers drug reaction seen ha find suggest ha may equival effect safer csa treat moder sever des
|
D016572;D015352
|
T121;T047;T116;T184
|
36,333,363
|
predict efficaci opioid sequestr intraven lipid emuls use biolog relev vitro model drug distribut intraven lipid emuls ile among use util treatment poison caus lipophil substanc bodi evid regard benefit treatment grow inform opioid ile interact still scarc work impact ile distribut buprenorphin fentanyl butorphanol use various concentr ngml investig two differ vitro model use disposit drug plasma ultracentrifug distribut simul biophas cell monolay fibroblast je macrophag confirm abil ile sequest three drug interest result decreas aqueous part plasma buprenorphin fentanyl butorphanol respect moreov ile affect drug distribut biophas vitro howev case drug concentr cell decreas buprenorphin fentanyl butorphanol respect two model reveal notabl differ ile potenti drug sequestr especi buprenorphin similar pronounc tendenc observ two drug discrep may result differ protein abund result drug protein bind system nevertheless result obtain vitro model correl well partit coeffici logp valu drug
|
D000701;D002047
|
T121;T131;T109
|
36,333,362
|
impact hormon therapi side effect health relat qualiti life distress well breast cancer survivor explor modulatori role adjuv hormon therapi aht health relat qualiti life qol subject well distress preval breast cancer bc survivor consid surviv phase cross section studi control group bc survivor particip examin interact effect aht time sinc end primari treatment show mani posit chang observ surviv phase experienc exclus survivor without aht aht prescrib longer time elaps associ decreas distress preval improv subject well qol seem turn point around fifth year final primari treatment survivor without aht signific improv sever area aht lesser extent expect improv qol throughout differ surviv phase signific impact adher mainten aht consequ likelihood surviv thus aht side effect routin assess health care provid gain accur knowledg allow improv qol bc survivor
|
D001943;D000073116
|
T201;T191;T101
|
36,333,360
|
deciph sex specif mirna heat record zebrafish last decad plethora microrna mirna report wide varieti physiolog process includ reproduct mani aquat organ howev mirnaom alter occur environment cue due water temperatur increment yet elucid aim identifi epigenet regul mediat mirna gonad climat chang scenario anim model zebrafish danio rerio subject high temperatur sex differenti treatment result male skew sex ratio adulthood fish reach adulthood gonad sequenc high throughput technolog total differenti express mirna ovari test respect identifi two month heat treatment heat record mirna involv human sex relat cancer predict target gene obtain reproduct relat function synteni zebrafish genom half predict target gene chromosom ovari chromosom place sex associ region sar local wild zebrafish spatial local gonad two select heat record mirna mir p mir p show exclus express ovarian germ cell present studi expand catalog sex specif mirna deciph first time thermosensit mirna zebrafish gonad might use potenti epimark predict environment past event
|
D015027;D035683
|
T123;T114;T013
|
36,333,359
|
risk cardiovascular diseas mortal patient diabet acut pancreat histori nationwid cohort studi patient acut pancreat ap may increas risk cardiovascular diseas cvd studi dealt associ ap risk cvd diabet patient studi aim investig risk cvd mortal patient diabet ap histori analyz larg scale nation claim databas korea data korean nation health insur servic databas analyz total particip type diabet mellitus underw general health examin enrol particip divid two group accord ap histori yes prior examin date follow data analyz primari endpoint occurr stroke myocardi infarct mi death cox proport hazard regress analysi use evalu associ ap histori risk stroke mi mortal exclus includ number particip without ap histori respect presenc ap histori show signific higher incid stroke mi mortal adjust hazard ratio confid interv risk stroke mi mortal respect age male sex current smoke drink signific increas risk death subgroup analys risk stroke mi mortal signific higher diabet particip ap histori without ap histori year follow suggest activ manag cardiovascular risk factor necessari diabet patient ap histori
|
D002318;D003924;D010195;D009203;D020521
|
T047;T046
|
36,333,358
|
metabolit annot known unknown knowledg guid multi layer metabol network liquid chromatographi mass spectrometri lc ms base untarget metabolom allow measur known unknown metabolit metabolom howev unknown metabolit annot major challeng untarget metabolom develop approach name knowledg guid multi layer network kgmn enabl global metabolit annot known unknown untarget metabolom kgmn approach integr three layer network includ knowledg base metabol reaction network knowledg guid msms similar network global peak correl network demonstr principl appli kgmn vitro enzymat reaction system differ biolog sampl putat unknown annot data set among unknown metabolit corrobor silico msms tool final valid metabolit absent common msms librari repositori mine synthesi chemic standard togeth kgmn approach enabl effici unknown annot substanti advanc discoveri recurr unknown metabolit common biolog sampl model organ toward deciph dark matter untarget metabolom
|
D053719;D055432
|
T063;T091
|
36,333,357
|
impact curcumin load physicochem mechan antimicrobi properti methacryl base experiment dental resin oral biofilm direct link one common chronic human diseas dental cari resin base dental materi signific potenti replac amalgam howev lack suffici antimicrobi power innov studi investig curcumin load dental resin util antimicrobi photodynam therapi apdt approach studi evalu effect curcumin load resin physicochem mechan adhes properti well antimicrobi respons associ blue light activ preliminari test involv degre convers dc sampl integr determin optim load curcumin restrict wt optim load test flexur strength fs water sorption ws solubl sl shear bond strength dentin sbs viabil streptococcus mutan jcm blue light dark condit h h biofilm result demonstr wt curcumin minim impact either fs sbs detect increas ws sl log cfuml reduct mutan light applic h h biofilm corrobor clsm imag highlight signific potenti novel apdt approach resin base dental materi
|
D003474;D003731;D010778;D000890
|
T061;T121;T109;T033;T047;T130
|
36,333,356
|
identif evolutionarili conserv regul muscl mitochondri network organ mitochondri network provid coordin energi distribut throughout muscl cell howev pathway specifi mitochondri network incomplet understood unclear might affect contractil fiber type show natur energet demand place drosophila melanogast muscl yield nativ cell type among contractil mitochondri network type regul differenti proteom analys indirect flight jump leg muscl togeth muscl misexpress known fiber type specif factor salm identifi transcript factor h cut potenti mitochondri network regul demonstr h oper downstream salm regul flight muscl contractil mitochondri network type convers h regul mitochondri network configur contractil type jump leg muscl find cut regul salm express flight muscl mitochondri network configur leg muscl data indic cell type specif regul muscl mitochondri network organ evolutionarili conserv transcript factor cut salm h
|
D004331;D029721
|
T123;T116;T204
|
36,333,355
|
sick absenc among young employe privat public sector histori depress anxieti aim investig occurr durat sick absenc sa among young employe previous depressionanxieti privat public sector popul base prospect studi includ swedish twin individu age year follow regard sa data previous depressionanxieti came two screen survey data sa employ sector receiv nation registri descript statist logist regress use also control famili factor proport employe sa signific higher among compar without previous depressionanxieti regardless employ sector individu previous depressionanxieti increas risk futur sa privat ci public sector ci famili factor play role associ among employe privat sector higher proport long term sa observ among employe previous depressionanxieti privat compar public sector conclud previous depressionanxieti tend increas risk sa among young employe employ sector wherea long term sa seem preval among privat compar public sector
|
D017150;D018582
|
T078;T098;T079;T081;T064
|
36,333,354
|
whole embryon identif matern microchimer cell type mous use singl cell rna sequenc even though mother fetus placent mammal immunolog non self respect one mutual exchang small number cell known occur matern cell enter fetus call matern microchimer cell mmc cell thought involv differ physiolog phenomena establish immun toler tissu repair pathogenesi deterior inflammatori diseas congenit malform specif mmc cell type report associ phenomena contribut mmc cell differ outcom remain unknown one possibl hypothes differ embryo differ repertoir mmc cell type lead bias embryo toward differ fate date studi succeed identifi mmc cell type repertoir singl embryo accord isol mmc cell whole mous embryo determin type analyz mmc cell type variabl combin previous establish whole embryon mmc isol method singl cell rna sequenc success estim cell type repertoir mmc cell isol mous embryo major mmc cell immun relat cell myeloid cell granulocyt also detect stem cell like mmc cell express prolifer marker gene termin differenti cell hypothes note statist signific inter individu variat proport immun relat cell differ embryo success estim mmc cell type individu whole mous embryo proport immun relat cell signific differ among individu embryo suggest variat one potenti mechan under differ mmc relat physiolog phenomena offspr find provid insight cell level epigenet matern cell
|
D010920;D004622
|
T018
|
36,333,353
|
combin microbi biogeochem dataset high latitud ecosystem respect methan cycl high latitud experienc intens ecosystem chang climat warm under methan ch cycl dynam remain unresolv despit crucial climat feedback atmospher ch emiss heterogen result local geochem driver global climat factor microbi productionconsumpt balanc holist studi mandatori captur ch cycl complex report larg set integr microbi biogeochem data sampl use concert sampl strategi experiment protocol studi follow intern standard ensur inter comparison data amongst three high latitud region alaska siberia patagonia dataset encompass differ repres environment featur eg lake wetland tundra forest soil high latitud site respect heterogen eg characterist microtopograph pattern data includ physicochem paramet greenhous gas concentr emiss organ matter character trace element nutrient isotop microbi quantif composit dataset address need robust physicochem framework conduct contextu futur research interact climat chang biogeochem cycl microbi communiti high latitud
|
D000074382;D064307
|
T001;T197;T032;T028
|
36,333,351
|
base edit mediat dissect globin cis regulatori element therapeut reactiv fetal hemoglobin express sickl cell diseas thalassemia affect product adult hemoglobin chain clinic sever lessen mutat caus fetal globin express adult life ie hereditari persist fetal hemoglobin mutat cluster nucleotid upstream hbg transcript start site either reduc bind lrf repressor recruit klf activ use base edit generat varieti mutat region hbg promot includ potent combin four eight globin induc mutat edit patient hematopoiet stemprogenitor cell safe lead fetal hemoglobin reactiv rescu patholog phenotyp creation klf activ bind site potent strategi even long term repopul hematopoiet stemprogenitor cell compar cas nucleas approach base edit avoid generat insert delet larg genom rearrang result higher globin level result demonstr base edit hbg promot safe univers strategi treat hemoglobinopathi
|
D017086;D000755
|
T047
|
36,333,350
|
databas seed plant taxonomi geographi ecolog qinl daba mountain adjac area qinl daba mountain span subtrop warm temper zone one remark biodivers hotspot china establish complet checklist seed plant organ natur reserv qinl daba mountain adjac area import basi manag util plant resourc first collect seed plant speci data publish checklist repres natur reserv qinl daba mountain adjac area second comprehens systemat sort integr data third proofread revis data help r languag flora china dataset final set seed plant databas contain record includ name order famili genus life form endem speci entireti qinl daba mountain databas contain speci seed plant belong genera famili order account china seed plant
|
D044822;D012639
|
T002;T080
|
36,333,349
|
evalu diagnost valu multi detector brain ct angiographi diagnos acut cerebr venous thrombosi cerebr venous sinus thrombosi cvst rare type venous thromboembol most affect young adult despit improv imag studi diagnosi usual delay sever day averag diagnost delay seven day onset symptom still report condit crucial radiologist detect potenti lethal condit routin imag studi studi aim investig diagnost valu multi detector brain cta diagnos acut cvt search pictur archiv communic system pac tertiari level academ hospit march march collect patient contrast enhanc mrv brain cta acquir admiss total patient found pac databas met criteria blind multidetector row comput tomograph angiographi mdcta evalu sensit specif accuraci mdcta detect cvst emerg set center mri scanner avail mdcta use instead ce mrv diagnosi csvt good sensit specif
|
D020767;D020246
|
T047;T046
|
36,333,346
|
human mobil robot interact retail environ technolog advanc human robot interact hri boost overal system effici product howev allow robot present close human inevit put higher demand precis human motion track predict dataset contain human robot oper share space receiv grow attent may facilit varieti robot human system research dataset track hri rich inform video imag daili activ rare seen paper introduc novel dataset focus social navig human robot futur orient wholesal retail trade wrt environ https uf retail cobot datasetgithubio eight particip perform task common undertaken consum retail worker minut data collect includ robot human trajectori human full bodi motion captur eye gaze direct contextu inform comprehens descript categori data stream well potenti use case includ furthermor analysi multipl data sourc futur direct discuss
|
D012371
|
T090
|
36,333,343
|
phenotyp trait variat long term multisit common garden experi scot pine scotland multisit common garden experi expos common pool genet divers rang environ allow quantif plastic genet compon trait variat tree speci studi must long term typic express matur trait mani year well evalu stand genet divers experi provid ongo test genet variat chang environment condit form vital resourc understand speci respond abiot biotic variat final quantit assess phenotyp variat essenti pair rapid accumul genom data advanc understand genet basi trait variat interact climat chang describ multisit popul progeni common garden experi econom ecolog import tree speci scot pine collect across nativ rang scotland grown three contrast environ phenotyp trait includ height stem diamet budburst measur grow season nurseri field site dataset present wide rang applic
|
D041605
|
T002
|
36,333,342
|
oligoadenyl synthetaselik oasl protect atherosclerosi maintain endotheli nitric oxid synthas mrna stabil endotheli nitric oxid synthas eno decreas follow inflammatori stimul master regul endotheli homeostasi maintain optim eno level import cardiovascular event howev littl known regard mechan eno protect studi demonstr regulatori role endotheli express oligoadenyl synthetas like oasl maintain eno mrna stabil athero prone condit consid clinic implic lack endotheli oasl acceler plaqu progress preced endotheli dysfunct elev vascular inflamm decreas bioavail follow impair eno express mechanist knockdown pikakt signal depend oasl express increas erk nf b activ decreas nos gene name eno mrna express upregul negat regulatori mir wherea mir inhibitor rescu effect oasl knockdown result suggest oasloasl regul endotheli biolog protect nos mrna target mir repres ration therapeut strategi eno mainten vascular diseas
|
D035683;D050197
|
T123;T047;T046;T114
|
36,333,341
|
develop general fourier fick law electro osmot mhd flow sodium algin base casson nanofluid inclin microchannel exact solut entropi generat electro osmot flow via microchannel numer use contemporari world includ biochem pharmaceut industri research explor electroosmot flow casson type nanofluid sodium algin nanoparticl vertic tilt microchannel addit transvers magnet field also consid flow fluid influenc heat mass transmiss also explor aforement physic process repres partial differenti equat util suitabl dimensionless variabl nondimension furthermor non dimension classic system fraction use general fourier fick law general made use caputo deriv descript analyt solut veloc temperatur concentr profil obtain combin method laplac fourier interest influenc sever physic characterist fraction paramet casson fluid paramet thermal mass grashof number zeta potenti paramet display moreov result show volum fraction nanoparticl enhanc rate heat transfer skin friction sherwood number also angl inclin enhanc fluid veloc
|
D057446;D000464
|
T121;T122;T070;T109
|
36,333,340
|
sar cov quasi speci analysi patient persist nasopharyng shed time new unpreced viral pandem mani question ask genom evolut sar cov emerg differ variant lead therapeut immun evas surviv genet high labil rna virus nasopharyng persist infecti virus beyond day prove constant interact human immun system increas intra individu mutat possibl perform prospect high throughput sequenc studi artic nanopor sar cov call persist patient compar non persist popul analyz quasi speci present singl sampl time global intra individu variabl persist patient found higher control mean standard deviat versus sd respect p detail analysi found greater differ persist non persist patient non sever covid two group infect clade furthermor found minor ny ph mutat cloud patient signific differ found group question sar cov viral variant genesi remain investig need prevent new viral propag consequ quasi speci analysi could import key watch
|
D000086402;D000086382
|
T005;T067;T047
|
36,333,339
|
anisotrop charg trap phototransistor unlock ultrasensit polarimetri bionic navig abl probe polar state light crucial applic medic diagnost intellig recognit inform encrypt bio inspir navig current state art polarimet base anisotrop semiconductor enabl direct linear dichroism photodetect without need bulki complex extern optic howev polar sensit restrict inher optic anisotropi lead low dichroic ratio typic smaller ten unveil effect general strategi achiev fold enhanc polar sensit exploit anisotrop charg trap effect organ phototransistor polar depend trap photogener charg carrier provid anisotrop photo induc gate bias current amplif result record high dichroic ratio reach extinct ratio commerci polar find enabl demonstr chip polar free bionic celesti compass skylight base polar navig result offer fundament design principl effect rout develop next generat high polar sensit optoelectron
|
D001701;D055095
|
T090
|
36,333,338
|
pan cancer singl cell analysi reveal heterogen plastic cancer associ fibroblast tumor microenviron cancer associ fibroblast caf predomin compon tumor microenviron tme influenc cancer hallmark without systemat investig ubiquit characterist across differ cancer type perform pan cancer analysi sampl across solid cancer type profil tme singl cell resolut illustr commonalitiesplast heterogen caf activ trajectori major caf type divid three state exhibit distinct interact cell compon relat prognosi immunotherapi moreov minor caf compon repres altern origin tme compon eg endothelia macrophag particular ubiquit present endotheli mesenchym transit caf may interact proxim spp tumor associ macrophag implic endotheli mesenchym transit surviv stratif studi comprehens profil share characterist dynam caf highlight heterogen plastic across differ cancer type browser integr pan cancer singl cell inform avail https gist fglgithubiosc caf atlas
|
D000072645;D009369
|
T191;T025
|
36,333,337
|
comput analysi arrhythmogenesi kcnh ti mutat associ short qt syndrom pharmacolog effect quinidin sotalol short qt syndrom sqts rare danger genet diseas research conduct comprehens silico investig arrhythmogenesi kcnh ti associ sqts use multi scale human ventricl model markov chain model kr develop first reproduc experiment observ incorpor cell tissu organ model explor mutat provid substrat ventricular arrhythmia use ti markov model explicit reveal subcellular level function alter ti mutat particular chang ion channel state difficult demonstr wet experi follow tissu organ model also success reproduc chang dynam reentrant spiral wave impair rate adapt heart ti mutat term pharmacotherapi replic differ effect drug various condit use ident mathemat descript drug studi simul action effect drug quinidin various physiolog level also elucid kr inhibitor sotalol fail sqt patient profound analyz mutat depend action
|
D011802;D013015
|
T121;T109
|
36,333,335
|
site specif crispr base mitochondri dna manipul limit grna import achiev crispr cas base manipul mitochondri dna mtdna long stand goal would great relev diseas model clinic applic project aim deliv cas mitochondria human cell analyz cas induc mtdna cleavag measur result mtdna deplet multiplex qpcr initi experi found measur subtl effect mtdna copi number challeng high biolog variabl detect signific cas caus mtdna degrad overcom challeng abl detect cas activ mtdna deliv cytosin base editor cas mitochondria measur effect c mutat mtdna unlik regular cas cut leav perman mark mtdna detect amplicon sequenc even effici low detect low level c mutat cell expos mitochondri target cas surpris occur regardless whether guid rna grna specif target site non target grna use unspecif target activ show cas technic edit mtdna also strong indic grna import mitochondria success go forward mitochondria target cas base editor use tool valid success grna deliveri mitochondria without ambigu approach reli quantifi mtdna copi number
|
D017394;D004272
|
T123;T114
|
36,333,334
|
use biolog amniot membran treatment recurr macular hole evalu clinic therapeut effect techniqu biolog amniot membran bam use treatment patient recurr macular hole prospect nonrandom case seri studi eye patient recurr macular hole alreadi undergon surgeri par plana vitrectomi intern limit membran peel evalu surgeri bam use cover macular area c f tamponad perform patient phacoemulsif combin intraocular len implant perform simultan patient cataract patient follow least half year main outcom whether macular hole close morpholog chang macular graft best correct visual acuiti intraocular pressur iop indic eye recurr macular hole close two case bam shift half month surgeri patient underw second surgeri adjust posit bam perform cf tamponad month follow patient improv visual acuiti va patient chang va mean va increas surgeri surgeri p mean iop decreas surgeri surgeri p serious complic occur case techniqu use biolog amniot membran effect treatment patient recurr macular hole
|
D012167;D019773
|
T047;T020
|
36,333,327
|
cdgap maintain podocyt function modul focal adhes src kinas depend manner rho gtpase regul actin cytoskeleton activ modul gtpase activ protein gap guanin nucleotid exchang factor gef glomerular podocyt numer actin base project call foot process alter characterist proteinur kidney diseas report previous rac hyperactiv podocyt caus proteinuria glomerulosclerosi mice howev gap gef modul rac activ podocyt remain unknown use proxim base ligat assay identifi cdgap arhgap pix arhgef major regulatori protein interact rac human podocyt cdgap interact pix basic region upon egf stimul transloc plasma membran podocyt cdgap deplet podocyt alter cell motil increas basal rac cdc activ stimul egf cdgap deplet podocyt show impair pix membran transloc tyrosin phosphoryl reduc activ src kinas focal adhes kinas paxillin system podocyt specif cdgap knockout mice develop mild signific proteinuria exacerb adriamycin collect find show cdgap contribut maintain podocyt function protect injuri
|
D050199
|
T025
|
36,333,326
|
electron photoreceptor enabl prosthet visual acuiti match natur resolut rat local stimul inner retin neuron high acuiti prosthet vision requir small pixel minim crosstalk neighbor electrod local return electrod within pixel limit crosstalk constrain electr field thus preclud effici stimul subretin pixel smaller demonstr high resolut prosthet vision base novel design photovolta array field confin achiev dynam leverag adjust conduct diod forward bias turn design pixel transient return valid comput model field confin optic control circuit vitro vivo measur import use strategi demonstr grate acuiti pixel match pixel pitch pixel reach limit natur visual resolut rat method enabl custom field shape base individu retin thick distanc implant pave way higher acuiti prosthet vision atroph macular degener
|
D057488
|
T074
|
36,333,324
|
vechat correct error long read use variat graph error correct canon first step long read sequenc data analysi current self correct method howev affect consensus sequenc induc bias mask true variant haplotyp lower frequenc show mix sampl unlik consensus sequenc templat graph base refer system affect bias mistaken mask true variant error present vechat approach implement idea vechat base variat graph popular type data structur pangenom refer system extens benchmark experi demonstr long read correct vechat contain pacif bioscienc time oxford nanopor technolog less error correct state art approach use vechat prior long read assembl signific improv haplotyp awar assembl vechat easi use open sourc tool public avail https githubcomhaplokitvechat
|
D000465;D058608
|
T170;T082
|
36,333,323
|
reward expect extinct restructur degrad ca spatial map loss dopaminerg reward proxim signal hippocamp place cell support reward relat spatial memori form cognit map repres reward locat strength memori modul extent reward expect encod howev circuit mechan under modul unclear find reward expect extinguish mice remain engag environ yet place cell represent reward vanish place field remap throughout environ increas place field trial trial reliabl decreas interest ventral tegment area vta dopaminerg axon ca exhibit ramp reward proxim signal depend reward expect inhibit vta dopaminerg neuron larg replic effect extinguish reward expect conclud chang reward expect restructur ca cognit map determin map reliabl modul dopaminerg vta ca reward proxim signal thus intern state high reward expect enhanc encod spatial memori reinforc hippocamp cognit map associ reward
|
D009042;D012201
|
T078;T041;T080
|
36,333,322
|
osteocyt direct regul osteolysi via myd signal bacteri bone infect impact bone cell activ bacteri induc osteolysi remain elus show matrix embed osteocyt stimul bacteri pathogen associ molecular pattern pamp direct drive bone resorpt myd regul signal pathway mice lack myd primarili osteocyt protect osteolysi caus calvari inject bacteri pamp resist alveolar bone resorpt induc oral porphyromona gingivali pg infect contrast mice target myd restor osteocyt exhibit osteolysi inflammatori cell infiltr vitro bacteri pamp induc signific higher express cytokin rankl osteocyt osteoblast mechanist activ osteocyt myd pathway regul rankl increas bind transcript factor creb stat rankl enhanc suppress k ubiquitin crebcreb bind protein stat system administr myd inhibitor prevent jawbon loss pg driven periodont find reveal osteocyt direct regul inflammatori osteolysi bone infect suggest myd downstream rankl regul osteocyt therapeut target osteolysi periodont osteomyel
|
D010014;D016301;D010518;D010019
|
T047;T046
|
36,333,321
|
ligand switchabl nanoparticl resembl viral surfac sequenti drug deliveri improv oral insulin therapi mutual interfer surfac ligand multifunct nanoparticl remain signific obstacl achiev optim drug deliveri efficaci develop ligand switchabl nanoparticl resembl viral uniqu surfac enabl fulli display divers function nanoparticl modifi ph respons stretchabl cell penetr peptid pep liver target moieti gal pepgal pnps oral administ acid environ trigger extens pep surfac virus like manner enabl pepgal pnps travers intestin barrier effici subsequ gal expos pep fold physiolog ph therebi allow specif target pepgal pnps liver proof concept insulin load pepgal pnps fabric exhibit effect intestin absorpt excel hepat deposit insulin crucial pepgal pnps increas hepat glycogen product fold contribut mainten glucos homeostasi effect diabet manag overal studi provid promis approach achiev full potenti divers ligand multifunct nanoparticl
|
D007328;D053758
|
T125;T121;T116;T073
|
36,333,320
|
amplif integr microscop motion high densiti rotaxan mechan interlock network integr individu microscop motion perform task macroscop sale common live organ howev develop artifici materi molecular level motion could amplifi behav macroscop still challeng herein present class mechan interlock network min carri dens rotaxan backbon model system understand macroscop mechan properti stem integr amplif intramolecular motion embed rotaxan motif one hand motion mechan bond introduc origin dangl chain network synergi numer microscop motion lead expans entir network impart good stretchabl punctur resist min hand dissoci host guest recognit subsequ slide motion repres peculiar energi dissip pathway whose integr amplif result bulk materi favor tough damp capac thereinto develop continu stress relax method elucid microscop motion rotaxan unit contribut understand relationship cumul microscop motion amplifi macroscop mechan perform
|
D043862
|
T121;T109
|
36,333,318
|
swin transform base model mosquito speci identif mosquito transmit number parasit pathogen result fatal diseas speci identif prerequisit effect mosquito control exist morpholog molecular classif method evit disadvantag introduc deep learn techniqu mosquito speci identif balanc high definit mosquito dataset origin imag cover speci construct three round screen adjust test first round among convolut neural network transform model second round among swin transform variant third round imag size propos first swin transform base mosquito speci identif model swin msi accuraci f score visual identif process morpholog key use swin msi similar use human swin msi realiz subspeci level identif culex pipien complex accuraci novel speci categor present promis approach mosquito identif mosquito born diseas control
|
D000072138;D003465
|
T204
|
36,333,316
|
effect human mesenchym stem cell secretom administr morphin self administr relaps two anim model opioid depend present studi investig possibl therapeut effect human mesenchym stem cell deriv secretom morphin depend relaps studi new model chronic voluntari morphin intak wistar rat show classic sign morphin intox sever naloxon induc withdraw syndrom singl intranas system administr mscs secretom fulli inhibit p voluntari morphin intak reduc post depriv relaps intak p sinc sever studi suggest signific genet contribut chronic use mani addict drug effect mscs secretom morphin self administr studi rat bred high alcohol consum uchb rat sub chronic intraperiton administr morphin access increas concentr morphin solut water avail anim led uchb rat prefer ingest morphin solut water attain level oral morphin intak rang wistar model intranas administ mscs secretom uchb rat dose depend inhibit morphin self administr p singl intranas dose msc secretom administ morphin depriv period impos chronic morphin consum uchb rat inhibit access morphin relaps intak p wistar uchb rat model mscs secretom administr revers morphin induc increas brain oxid stress neuroinflamm consid key engin perpetu drug relaps overal present preclin studi suggest product secret human mesenchym stem cell may valu treatment opioid addict
|
D009293;D013375;D059630
|
T184;T025;T048
|
36,333,315
|
translat regulatori factor bzw regul preimplant embryo develop compact restrict global non aug initi protein synthesi essenti step gene express develop mammalian preimplant embryo complex high regul process accuraci translat initi codon import various gene express program howev mechan regul aug non aug codon initi earli embryo remain poor understood bzw key factor determin mrna translat start codon show bzw essenti earli embryon develop mice bzw knockdown embryo fail undergo compact show decreas blastocyst format rate also observ defect differenti capac implant potenti bzw interfer investig reveal bzw knockdown caus level translat initi cug start codon increas declin bzw level result decreas protein synthesi preimplant embryo wherea total mrna level alter therefor conclud bzw contribut protein synthesi earli embryon develop restrict non aug translat initi
|
D001755;D010064
|
T018;T040
|
36,333,314
|
lamin ac depend chromatin architectur safeguard nave pluripot prevent aberr cardiovascular cell fate function tight control cell fate choic crucial normal develop show lamin ac play key role chromatin organ embryon stem cell esc safeguard nave pluripot ensur proper cell fate choic cardiogenesi report chang chromatin compact local cardiac gene lmna esc result precoci activ transcript program promot cardiomyocyt versus endotheli cell fate accompani prematur cardiomyocyt differenti cell cycl withdraw abnorm contractil gata activ lamin ac loss gata silenc haploinsuffici rescu aberr cardiovascular cell fate choic induc lamin ac defici uncov diverg function lamin ac nave pluripot stem cell cardiomyocyt distinct contribut transcript alter patient lmna associ cardiomyopathi conclud disrupt lamin ac depend chromatin architectur esc primari event lmna loss function cardiomyopathi
|
D034904;D002843
|
T123;T116
|
36,333,313
|
modular total synthes tran clerodan sesquiterpen hydro quinon via tail head cyclize reduct coupl strategi tran clerodan sesquiterpen hydro quinon grow class natur product exhibit wide rang biolog activ although differ type natur product featur tran decalin core structur report total synthes two member tran clerodan five member sesquiterpen hydro quinon well propos structur dysidavaron via modular synthet rout bioinspir tail head cyclize strategi develop synthes tran decalin architectur use two diastereochem complementari radic polyen cyclize reaction catalyz ti iii mediat mn iii respect differ type side chain introduc challeng nickel catalyz reduct coupl steric hinder alkyl halid synthesi propos dysidavaron prove wrong structur assign natur product
|
D045785;D012717;D001688
|
T123;T121;T109
|
36,333,310
|
yiac cobb regul lysin lactyl escherichia coli lysin lactyl kla recent report particip regul transcript human cell howev character regulatori mechan function consequ kla prokaryot remain unclear report yiac function lysin lactylas cobb serv lysin delactylas regul metabol demonstr yiac catalyz addit kla cobb eras ptm vitro intracellular moreov show ydif catalyz format lactyl coenzym donat lactyl group kla quantit proteom analysi reveal endogen kla site target cobb candid target yiac escherichia coli e coli furthermor present kla influenc function metabol enzym interest demonstr cobb specif modul activ pykf regul kla promot glycolysi bacteri growth studi identifi regulatori enzym function network kla reveal kla mediat molecular mechan catalyz cobb glycolysi regul e coli
|
D029968;D037761
|
T126;T116
|
36,333,308
|
long term monitor intravit biolog process use fluoresc protein assist nir ii imag high spatial resolut low background deep tissu penetr made near infrar ii nir ii fluoresc imag one critic tool vivo observ measur howev relat short retent time potenti toxic synthet nir ii fluorophor limit long term applic report use infrar fluoresc protein irfp vitro vivo nir ii probe permit prolong continu imag month repres exampl irfp knock mous genom generat transgen model allow tempor andor spatial express control probe demonstr feasibl genuin diagnost context adopt two liver regener model success track process week perform monitor efficaci compar ct superior indocyanin green dye also abl effect observ pancrea despit deep locat physiolog patholog condit result indic irfp assist nir ii fluoresc system suitabl monitor various tissu vivo biolog process provid power noninvas long term imag platform
|
D061848;D001686
|
T060;T070;T038
|
36,333,306
|
genet encod fluoresc biosensor detect itacon subcellular resolut live macrophag itacon newli discov endogen metabolit promot anti inflammatori program innat immun respons precis mechan under effect remain poor understood owe primarili limit avail itacon monitor techniqu develop valid genet encod fluoresc itacon biosensor bioita direct monitor itacon dynam subcellular compart live macrophag util bioita monitor itacon dynam respons lipopolysaccharid lps stimul context modul itacon transport metabol moreov show sting activ induc itacon product inject aav express cytosol bioita mice allow direct report elev itacon level activ macrophag deriv lps inject mice thus bioita enabl subcellular resolut imag itacon live macrophag
|
D008070;D015374
|
T059;T075;T109
|
36,333,305
|
pathogen variant slf smc caus segment chromosom mosaic varieg hyperploidi embryon develop dictat tight regul dna replic cell divis differenti mutat dna repair replic gene disrupt equilibrium give rise neurodevelopment diseas character microcephali short statur chromosom breakag identifi biallel variant two compon rad slf smc genom stabil pathway slf smc patient microcephali short statur cardiac abnorm anemia patient deriv cell exhibit uniqu chromosom instabl phenotyp consist segment dicentr chromosom mosaic varieg hyperploidi signifi import segment chromosom name disord atel mean incomplet syndrom analysi atel syndrom cell reveal elev level replic stress part due reduc abil replic g quadruplex dna structur also loss sister chromatid cohes togeth data strengthen function link slf smc complex highlight distinct role pathway maintain genom stabil
|
D018797;D008831
|
T123;T047;T116;T019
|
36,333,303
|
atom level structur respons environment condit electron diffract electron microscopi wide use structur analysi protein pharmaceut product various function materi past decad howev one fact often overlook crystal structur might sensit extern environ respons manner bring uncertainti structur determin structur properti correl report atom level ab initio structur determin microcryst combin electron diffract ed environment transmiss electron microscop tem environment condit includ cryo heat gas liquid success achiev use situ holder reveal simuli respons structur crystal remark structur chang direct resolv ed one flexibl metal organ framework mil owe respons framework pressur temperatur guest molecul etc
|
D004583;D011506
|
T081;T123;T196;T116
|
36,333,302
|
matern stress vulner depress cope matern care strategi consequ adolesc offspr depress mother often find mother child interact challeng matern stress may impair mother child attach may increas risk negat development consequ use rat differ vulner depress like behavior wistar kyoto investig impact stress matern separ ms matern behavior adolesc offspr cognit ms kyoto dam increas pup contact result higher oxytocin level lower anxieti like behavior wean worsen adolesc offspr cognit behavior wherea ms wistar dam elicit higher qualiti pup direct behavior increas brain deriv neurotroph factor bdnf offspr seem prevent negat impact cognit hypothalam oxytocin seem affect salienc social environ cue negat kyoto lead differ cope strategi find highlight import contextu individu factor understand oxytocin role modul matern behavior stress regulatori process
|
D008426;D010121
|
T125;T121;T116;T067
|
36,333,301
|
high resolut ancient sedimentari dna show alpin plant divers associ human land use climat chang european alp high rich speci futur may threaten ongo chang human land use climat reconstruct veget temperatur human impact livestock past year lake sulsseewli base sedimentari ancient plant mammal dna pollen spore chironomid microcharco assembl high complet local dna refer librari phyloalp plant taxa use obtain except rich sedadna record plant taxa veget main respond climat earli holocen human activ addit influenc veget ka onward land use shift episod graze neolith bronz age agropastor middl age associ human deforest allow coexist plant speci typic found differ elev belt lead level plant rich characteris current high divers region find indic posit associ low intens agropastor activ precipit mainten uniqu subalpin alpin plant divers european alp
|
D057231;D000072441
|
T123;T070;T114
|
36,333,300
|
mitochondri fission process control inner membran integr protect heart failur mitochondria paramount metabol surviv cardiomyocyt show mitochondri fission process mtfp inner mitochondri membran imm protein dispens mitochondri divis yet essenti cardiac structur function constitut knockout cardiomyocyt mtfp mice result fatal adult onset dilat cardiomyopathi accompani extens mitochondri cardiac remodel transit heart failur prior onset diseas knockout cardiac mitochondria display specif imm defect futil proton leak depend upon adenin nucleotid translocas increas sensit open mitochondri permeabl transit pore mtfp physic genet interact collect data reveal new function mtfp control bioenerget effici cell death sensit defin import prevent pathogen cardiac remodel
|
D063154;D006333
|
T047;T046;T043
|
36,333,299
|
microscop stage live cell reveal chang dynam transcript burst differenti determin mechan gene switch develop key aim current biomed research gene transcript wide observ occur discontinu fashion short burst activ interspers period inact current known dynam behaviour chang mammalian cell differenti investig use microscop analysi monitor mous globin transcript live cell throughout erythropoiesi find chang overal level globin transcript close associ chang fraction time gene spend activ transcript state identifi differ pattern transcript burst throughout differenti maxim transcript activ occur mid phase differenti earli differenti observ increas fluctuat transcript activ wherea peak gene express earli erythroblast transcript relat stabl later differenti globin express declin observ variabl transcript within individu cell propos observ chang transcript behaviour may reflect chang stabil activ transcript compart gene express regul differenti
|
D004900;D004920
|
T025;T042
|
36,333,298
|
blockad fgffgfr partial overcom bone marrow mesenchym stromal cell mediat progress cell acut lymphoblast leukaemia develop acut lymphoblast leuakemia part attribut effect bone marrow bm microenviron especi mesenchym stromal cell mscs interact bilater leukaemia cell lead progress order find mscs base microenviron target therapeut strategi notch induc cell mice model use dynam alter bm mscs increas cell viabil develop observ mice deriv stroma base condit leukaemia cell show signific elev growth capac indic mscs particip leukaem nich format rna sequenc result reveal deriv mscs secret fibroblast growth factor fgf combin fibroblast growth factor receptor fgfr leukaemia cell result activ pikaktmtor signal pathway leukaemia cell vitro block interact fgf fgfr bgj infigratinib fgfr kinas inhibitor knockdown fgf mscs interfer caus deactiv pikaktmtor pathway dysregul gene associ cell cycl apoptosi cell lead decreas leukaemia cell mous model receiv bgj overal surviv extend dissemin leukaemia cell bm spleen liver peripher blood decreas subcutan inject primari human cell mscs tumour growth suppress fgffgfr interrupt thus inhibit fgffgfr interact appear valid strategi overcom bm mscs mediat progress bgj could inde improv outcom provid theoret basi bgj bm microenviron base therapeut strategi control diseas progress
|
D054218;D059630
|
T191;T025
|
36,333,297
|
tumor factor stimul lysosom degrad tumor antigen undermin cross present lung cancer activ dendrit cell dcs present tumor antigen often suppress tumor report suppress induc tumor microenviron deriv factor activ activ transcript factor atf transcript factor downregul cholesterol hydroxylas chh loss chh antigen present cell isol human lung tumor associ tumor growth lung cancer progress accord mice lack chh dcs exhibit acceler tumor growth decreas infiltr impair activ intratumor cd cell mice establish measur long term immun malign cell undergo chemotherapi induc immunogen cell death mechanist downregul chh stimul membran fusion endo phagosom lysosom acceler lysosom degrad restrict cross present tumor antigen intratumor dcs administr sting agonist msa reduc lysosom activ dcs restor antigen cross present increas therapeut efficaci pd blockad tumour challeng chh depend manner studi highlight import downregul chh dcs tumor immun evas resist therapi
|
D045142;D008175
|
T191;T043
|
36,333,296
|
cd cell differenti status correl feasibl sustain unrespons follow oral immunotherapi food allergi oral immunotherapi oit provid safe effect desensit ds immun mechan under develop sustain unrespons su follow period avoid larg unknown compar high dimension phenotyp innat adapt immun cell subset particip previous report phase random control peanut oit trial achiev su vs ds vs allerg reaction upon food challeng withdraw period n vs respect among total intent treat particip lower frequenc nave cd cell termin differenti cd cd cell subset baselin pre oit associ su frequenc nave cd cell show signific posit correl peanut specif ara h specif ige level baselin higher frequenc il ifn cd cell post oit negat correl su find provid evid immun signatur consist certain cd cell subset frequenc potenti predict su follow oit
|
D021183
|
T047
|
36,333,294
|
amyloid associ increas solubl tau relat tau aggreg rate cognit declin earli alzheim diseas optim design anti amyloid anti tau clinic trial need better understand pathophysiolog cascad tau relat process therefor set investig solubl phosphoryl tau p tau relat accumul tau aggreg assess pet subsequ cognit declin across alzheim diseas ad continuum use human cross section longitudin neuroimag cognit assess data show earli stage ad increas concentr solubl csf p tau strong associ accumul insolubl tau aggreg across brain csf p tau level mediat effect tau aggreg higher solubl p tau concentr main relat faster accumul tau aggreg region strong function connect individu tau epicent earli stage higher solubl p tau concentr associ cognit declin mediat faster increas tau aggreg contrast ad dementia fibril solubl p tau level plateau cognit declin relat accumul rate insolubl tau aggreg data suggest therapeut approach reduc solubl p tau level might favor earli ad widespread insolubl tau aggreg
|
D000544;D060825;D000686
|
T047;T048
|
36,333,293
|
egfr induc suppress hpv ee mediat microrna p silenc brd protein hpv posit head neck squamous cell carcinoma egfr upregul establish biomark treatment resist aggress head neck cancer hnscc egfr target therapi shown benefit hpv negat hnscc surpris inhibit egfr hpv associ hnscc led inferior therapeut outcom suggest oppos role egfr two hnscc subtyp current studi aim understand link egfr hpv infect hnscc particular regul hpv oncoprotein e e demonstr egfr overexpress suppress cellular prolifer increas radiosensit hpv posit hnscc cell line egfr overexpress inhibit protein express brd known cellular transcript regul hpv ee express dna damag repair facilit inhibit egfr cetuximab restor express brd lead increas hpv e e transcript concord pharmacolog inhibit brd led suppress hpv e e transcript delay cellular prolifer sensitis hpv posit hnscc cell ionis radiat effect shown mediat egfr induc upregul microrna p consequ silenc target brd protein translat level repress hpv e e transcript restor p tumour suppressor function result suggest novel mechan egfr inhibit hpv ee oncoprotein express epigenet pathway independ mapk mediat microrna pbrd regul therefor target egfr may best cours therapi certain cancer type includ hpv posit hnscc target specif signal pathway brd could provid better potenti new treatment improv hnscc therapeut outcom
|
D030361;D002294;D009856;D006258;D035683
|
T123;T116;T191;T114;T047
|
36,333,290
|
super resolut microscopi enabl high effici surfac migrat emiss deplet nonlinear deplet fluoresc state stimul emiss constitut basi stimul emiss deplet sted microscopi despit signific effort past decad achiev super resolut low satur intens sted remain major technic challeng har surfac quench effect nagdf ybtm nanocryst report high effici emiss deplet surfac migrat use dual beam continu wave laser manipul scheme nm excit nm de excit achiev emiss deplet effici low satur intens kw cm emiss deplet surfac migrat gadolinium sublattic enabl super resolut imag sub nm later resolut approach circumv fundament limit high intens sted microscopi provid autofluoresc free excit background free imag satur intens three order magnitud lower convent fluorophor also demonstr super resolut imag actin filament hela cell label nm nanoparticl combin high photost lanthanid luminesc surfac migrat emiss deplet smed could provid power mechan low power super resolut imag biolog track well super resolv optic sensingwrit lithographi
|
D005456;D053758
|
T130;T073
|
36,333,289
|
collabor studi bladder cancer advocaci network genom analysi metastat urotheli cancer urotheli cancer genom analysi improv patient outcom research nct uc genom genom analysi biospecimen repositori studi patient metastat urotheli carcinoma report primari outcom uc genom proport subject receiv next generat sequenc ngs treatment option present initi genom analys clinic correl subject potenti treatment option howev receiv therapi base ngs found increas frequenc tp ek mutat compar non metastat cohort identifi featur associ benefit chemotherapi immun checkpoint inhibit includ basq stroma rich subtyp apobec mutat signatur sbs inflam tumor immun phenotyp final deriv comput model incorpor genom clinic featur predict immun checkpoint inhibitor respons futur work util biospecimen alongsid foundat analys toward better understand urotheli carcinoma biolog
|
D002295;D001749
|
T191
|
36,333,287
|
role dendrit cell immunomodul implant biomateri consid substanti role play dendrit cell dcs immun system bridg innat adapt immun studi dc mediat immun toward biomateri princip center adjuv effect facilit adapt immun codeliv antigen howev effect intrins properti biomateri dendrit cell clarifi recent research begun investig found biomateri nonadjuv could also regul immun function dcs thus affect subsequ tissu regener case protein adsorb onto biomateri surfac intrins properti direct orient conform form biomateri associ molecular pattern bamp thus review focus intrins physiochem properti biomateri absenc antigen affect dc immun function summar under signal pathway moreov preliminarili clarifi specif composit bamp interplay key molecul dcs heat shock protein hsps high mobil group box hmgb review provid new direct futur biomateri design modul host immun respons applic tissu engin immunotherapi
|
D001672;D003713
|
T122;T025
|
36,333,286
|
spatial analysi glioblastoma proteom reveal specif molecular signatur marker surviv molecular heterogen key featur glioblastoma imped patient stratif lead larg discrep mean patient surviv analyz cohort glioblastoma patient surviv rang month year tumor analyz mass spectrometri base spatial resolv proteom guid mass spectrometri imag integr protein express clinic inform highlight three molecular group associ immun neurogenesi tumorigenesi signatur high intra tumor heterogen furthermor set protein origin refer altern orf found statist signific base patient surviv time among protein protein signatur associ surviv express protein valid immunofluoresc addit cohort patient overal work character distinct molecular region within glioblastoma tissu base protein express may help guid glioblastoma prognosi improv current glioblastoma classif
|
D005909;D001932
|
T191
|
36,333,284
|
macc promot pancreat cancer metastasi interact emt regul snai metastasi domin caus cancer relat mortal metastasi associ colon cancer protein macc proven play critic role cancer metastasi howev prometastat role macc regul pancreat cancer pc metastat phenotyp remain elus report macc high express cancer genom atlas tcga tissu microarray tma identifi good indic poor prognosi overexpress knockdown macc pc cell correspond promot inhibit pancreat cancer cell migrat invas met proto oncogen receptor tyrosin kinas met independ manner notabl knockdown macc pc cell mark decreas liver metastat lesion liver metastasi model mechanist macc bind epitheli mesenchym transit emt regul snail famili transcript repressor snai drive emt via upregul transcript activ snai lead transactiv fibronectin fn tran repress cadherin cdh collect result unveil new mechan macc drive pancreat cancer cell metastasi suggest macc snai complex mediat mesenchym transit may therapeut target pancreat cancer
|
D010190;D003110
|
T191
|
36,333,283
|
retin chromophor charg deloc confin explain extrem photophys neorhodopsin understand rhodopsin sequenc modifi exact modul spectroscop properti retin chromophor prerequisit ration design effect optogenet tool one key problem establish rule satisfi achiev high fluoresc rhodopsin near infrar absorpt present paper use multi configur quantum chemistri construct comput model recent discov natur rhodopsin neorhodopsin display exact properti show model success replic relev experiment observ unveil geometr electron structur chromophor featur high diffus charg distribut along conjug chain model reveal charg confin process occur along chromophor excit state isomer coordin primari caus observ fluoresc enhanc
|
D012243;D012160
|
T123;T023;T116
|
36,333,282
|
contribut common rare genet variant variat metabol trait east asian metabol trait herit phenotyp wide use assess risk various diseas conduct genom wide associ analysi gwas nine metabol trait includ glycem lipid liver enzym level korean subject genotyp korea biobank array follow meta analysi gwas biobank japan identifi novel signal maf replic uk biobank addit discov rare maf variant co incid common loci ad allel seri although rare variant limit contribut overal trait varianc lead carrier substanti loss predict accuraci polygen predict diseas risk common variant alon captur group fold variat type diabet td preval integr genet risk score fast plasma glucos td rare protect variant studi highlight need consid joint contribut common rare variant inherit risk metabol trait relat diseas
|
D055106;D003924
|
T063;T047
|
36,333,281
|
singl cell spatial transcriptom reveal fibrosi relat immun landscap biliari atresia biliari atresia ba devast inflammatori fibros cholangiopathi neonat unknown aetiolog aim investig relationship two main characterist
|
D001656;D008107
|
T033;T019;T047
|
36,333,275
|
remov phosphat synthet wastewat compar studi activ clay use experiment design methodolog phosphat load industri wastewat result numer environment issu hard hit gulf gabe tunisia make environment protect one compel prioriti consequ studi aim first compar amount phosphat adsorb two type tunisian activ clay second goal assess optim phosphat remov effici clay use box behnken design bbd respons surfac methodolog result show highest adsorpt amount mg g mg g yield jebel haidoudi clay douiret clay respect valu demand initi phosphat concentr mg l contact time h ph thus kinet isotherm studi phosphat elimin synthet solut demonstr activ clay pseudo second order langmuir equat fit well experiment data respect result indic phosphat adsorpt might main chimisorpt phenomenon monolay process find confirm activ clay could consid compet cost effect effici ecolog altern elimin phosphat industri wastewat practition point activ clay could adopt effici cost effect adsorb optimum condit nomin mg l initi phosphat concentr h contact time ph probabl uptak mechan phosphat follow predomin acid base interact hydrogen bond
|
D062065;D014874
|
T131;T083;T069
|
36,333,113
|
parp upregul hyperglycemia via n methyladenosin modif promot diabet retinopathi poli adp ribos polymeras parp play irreplac role progress diabet retinopathi dr methyl mrna control gene express various physiolog patholog condit howev effect methyl parp express dr progress molecular level document studi show level parp inflammatori factor fibrosi marker signific upregul via evalu real time pcr western blot immunofluoresc vivo vitro experi edu cck apoptosi assay demonstr knockdown parp signific improv vital hrmec human retin microvascular endotheli cell even high glucos condit also prevent glucos induc inflamm fibrosi angiogenesi vivo mechanist dot blot rna pull immunoblot implement explor mechan mediat parp stabil function parp identifi target ythdf mediat modif overexpress ythdf substanti suppress parp mrna modif inhibit mrna express collect demonstr parp frequent upregul human retina contribut dr progress ythdf mediat modif epigenet regul diabet induc parp express find work may engend therapeut target treat diabet retinopathi
|
D003930;D006943;D003920
|
T033;T047
|
36,333,112
|
develop prolif vitreoretinopathi attenu chicken ovalbumin upstream promot transcript factor via inhibit epitheli mesenchym transit prolif vitreoretinopathi pvr intract condit rhegmatogen retin detach rd primari caus failur retin reattach surgeri studi aim investig effect chicken ovalbumin upstream promot transcript factor coup tf develop prolif vitreoretinopathi pvr vitro vivo adult retin pigment epithelium cell line use vitro experi immunocytochemistri assay real time quantit polymeras chain reaction western blot use measur express coup tf alpha smooth muscl actin sma e cadherin epitheli mesenchym transit emt observ cell count kit assay wound heal test express chang relat protein pvr rabbit model establish evalu imag fundus vitreous caviti patholog section coup tf express shown result prolifer migrat coup tf knockdown cell reduc compar control cell without transform growth factor tgf treatment tgf treatment sma express upregul arp cell kept coup tf knockdown cell e cadherin express regul group extent decreas coup tf knockdown cell smaller emt attenu arp cell coup tf knock vivo experi pvr sever attenu retin detach rate decreas th th day coup tf knockdown group conclus coup tf relat develop pvr coup tf knockdown attenu progress pvr suggest coup tf promis candid treatment pvr
|
D018630;D012163
|
T047
|
36,333,100
|
viscosupplement knee osteoarthr systemat review meta analysi evalu effect safeti viscosupplement pain function patient knee osteoarthr
|
D055676;D020370
|
T061;T047
|
36,333,098
|
csfr mediat myeloid cell deplet prolong lifespan aggrav distinct motor symptom model multipl system atrophi cns resid macrophag member myeloid lineag microglia fulfil manifold function import brain develop homeostasi context neurodegen diseas implic degen regen process discoveri distinct activ pattern includ increas phagocytosi indic damag role myeloid cell multipl system atrophi msa devast rapid progress atyp parkinsonian disord analyz gene express profil microglia mous model msa mbp h syn identifi diseas associ express profil upregul coloni stimul factor csf thus hypothes csf receptor mediat deplet myeloid cell use plx modifi diseas progress neuropatholog phenotyp mous model intrigu sex balanc analysi myeloid cell deplet mbp h syn mice reveal two face outcom compris improv surviv rate accompani delay onset neurolog symptom contrast sever impair motor function furthermor plx revers gene express profil relat myeloid cell activ reduc gene express associ transsynapt signal signal releas transcript chang accompani reduct dopaminerg neuron snpc striatal neurit densiti increas upon myeloid cell deplet mbp h syn mice togeth find provid insight complex two face role myeloid cell context msa emphas import care balanc benefici advers effect csfr inhibit differ model neurodegen disord clinic translat signific statement myeloid cell implic detriment diseas pathogenesi multipl system atrophi howev long term csfr depend deplet cell mous model multipl system atrophi demonstr two face effect involv improv surviv associ delay onset diseas reduc inflamm contrast sever impair motor function synapt signal neuron circuitri thus studi unravel complex role myeloid cell multipl system atrophi indic import function beyond previous describ diseas associ destruct phenotyp emphas need investig care individu fine tune immunolog process differ neurodegen diseas
|
D019578
|
T046
|
36,333,095
|
recurr mening malign tumor assess differ solitari fibrous tumorhemangiopericytoma spectrum case report solitari fibrous tumor sfts neoplasm grow mesenchym fusiform cell central nervous system mening common origin neoplasm although literatur report most sft benign neoplasm malign data describ recurr metastat lesion definit diagnosi includ immunohistochem profil assess cellular posit cd vimentin cd bcl recent studi demonstr nab stat gene fusion distinct molecular featur sft overexpress fusion protein nab stat nuclei cell sinc sever year pathologist group sft hemangiopericytoma hpc differ phenotyp entiti although neoplasm share numer featur articl base case recurr malign sft aim emphas differ sfthpc spectrum due diagnost therapeut prognost implic
|
D008577;D006393;D054364
|
T191
|
36,333,094
|
dorsal arachnoid web rare caus syringomyelia myelopathi dorsal arachnoid web condens arachnoid tissu dens adher pial surfac posterior aspect dorsal spinal cord infrequ describ literatur disrupt flow csf spinal subarachnoid space lead syringomyelia myelopathi sever theori origin scalpel sign magnet reson imag consid pathognomon condit illustr case year old man syringomyelia dorsal cord indent present spastic paraparesi gait instabl parasthesia bilater non radicular upper limb pain resolv follow excis web describ highlight import consid diagnosi case call idiopath syringomyelia encount
|
D013595
|
T047
|
36,333,093
|
molecular clinic character h km mutant non midlin glioblastoma case report literatur review classif tumor cns defin diffus midlin glioma h km mutant new tumor entiti locat cns midlin howev h km mutat non midlin glioblastoma rare characterist rare report year old girl present hyper intens lesion left tempor stem twi flair dwi biopsi perform molecular patholog diagnosi glioblastoma h km mutant accord possibl h km mutant examin diffus glioma without idh mutat develop midlin locat also non midlin locat
|
D005909;D001932;D005910
|
T191
|
36,333,092
|
primari central nervous system hodgkin lymphoma case report review literatur central nervous system cns involv context relapsedrefractori hodgkin lymphoma hl quit rare well known complic nevertheless primari cns hl exceed rare condit diagnosi base well defin morpholog immunohistochem featur addit isol involv cns spite limit casuistri twenti case report literatur avail data agre primari isol cns hl treat combin surgeri follow form adjuv therapi radiotherapychemotherapi carri better prognosi case cns involv context relapsedrefractori hl cns non hodgkin lymphoma herein report case year old femal patient diagnos primari cns hl patient treat complet surgic resect follow intrathec chemotherapi whole brain radiotherapi wbrt show fourteen month diseas free surviv time case report review avail literatur also present
|
D006689;D016543
|
T191
|
36,333,091
|
discrep ki label index brain orbit metastat lesion gastrointestin neuroendocrin tumor case report prolif activ examin ki label index li play pivot role manag gastrointestin neuroendocrin tumor gi net report indic intra patient heterogen ki li among metastat tumor site report case brain orbit metastas gi net show discrep ki li year old woman diagnos gi net liver bone metastas perform medic therapi headach right exophthalmo pain right eye refer depart magnet reson imag reveal tumor left occipit region right orbit diagnos metastat brain orbit tumor gi net surgic remov symptomat lesion perform diagnosi patholog confirm immunohistochem studi reveal discrep ki li lesion brain tumor versus orbit tumor sampl multipl metastat site may prevent underestim tumor prolif activ
|
D018358;D009918
|
T191
|
36,333,090
|
spontan acut bleed within subdur effus dural metastasi gastric cancer case report dural metastas uncommon find diagnosi normal appear dissemin stage malign tumor usual clinic silent could becom symptomat due mass effect develop subdur collect present case young woman recent oper gastric cancer present conscious deterior hemiparesi caus subdur collect examin patient drastic worsen neurolog status due acut subdur bleed within subdur collect patholog analysi diagnos dural metastasi gastric cancer malign associ subdur collect import suspect coexist dural metastas perform contrast enhanc ct scan magnet reson imag mri may help diagnosi surgeri indic mandatori evacu tumor involv dura caus accumul fluid coagul extern tumor membran avoid bleed
|
D013274;D013353;D008577
|
T047;T191;T020
|
36,333,089
|
intramedullari pancreat adenocarcinoma metastasi first case literatur pancreat cancer common gastrointestin malign often associ poor prognosi although liver general seen distant metastasi point shown metastas organ especi gastrointestin tract approxim metastas observ spinal cord
|
D000230;D010190;D013120
|
T191
|
36,333,088
|
salvag posterior atlantoaxi fixat techniqu retrospect studi sinc atlantoaxi region critic neurovascular anatomi limit bone surfac fusion applic choic salvag fixat techniqu high import discuss altern posterior atlantoaxi fixat surgeri techniqu
|
D013123
|
T061
|
36,333,087
|
endoscop endonas approach pituitari adenoma impact adenohypophys function studi case identifi presurg surgic factor associ develop hypopituitar recoveri endoscop endonas transsphenoid eet resect pituitari adenoma pas
|
D010911;D000236;D007018
|
T047;T191
|
36,333,086
|
outcom spinal cord injuri follow cervic fractur ankylos spondyl diffus idiopath skelet hyperostosi dish prospect cohort studi ankylos spine prone increas fractur risk even minor trauma lower cervic spine frequent injur fractur ankylos spine tend precipit spinal cord injuri sci object current studi assess incid manag outcom patient ankylosi spine sustain cervic fractur associ sci year period
|
D004057;D013167;D016103;D013119;D019838
|
T047;T037
|
36,333,085
|
evalu development profil children hydrocephalus object studi compar development characterist children hydrocephalus healthi children
|
D002657;D006849
|
T040;T033;T019;T039;T047
|
36,333,083
|
cognit complaint comorbid obstruct sleep apnea obstruct sleep apnea osa high preval sleep disord caus sleep fragment frequent awaken intermitt hypoxia osa cognit declin increas preval factor increas age bodi mass multipl area cognit affect includ attent execut function memori well emot function direct effect brain health although posit airway pressur therapi shown improv aspect cognit function fulli allevi cognit complaint inclus complementari approach comorbid associ osa could potenti enhanc treatment outcom
|
D020181;D060825
|
T047;T048
|
36,333,080
|
obstruct sleep apnea posit airway pressur usag popul neurolog diseas obstruct sleep apnea osa character repetit episod complet partial upper airway obstruct sleep worldwid estim million suffer treatment osa includ continu posit airway pressur cpap weight loss posit therapi oral applianc posit upper airway pressur oro maxillofaci surgeri hypogloss nerv stimul bariatr surgeri other cpap common prescrib treatment review neurolog condit stroke cognit declin epilepsi migrain discuss relat osa addit literatur regard improv condit follow treatment cpap explor
|
D020181;D004827
|
T033;T047
|
36,333,079
|
comorbid insomnia sleep apnea assess manag approach comorbid insomnia sleep apnea comisa high preval debilit condit difficult treat compar insomnia alon sleep apnea alon approxim sleep clinic patient sleep apnea report comorbid insomnia symptom comorbid insomnia associ lower adher posit airway pressur therapi obstruct sleep apnea manag approach includ target treatment insomnia sleep apnea lead best treatment outcom patient comisa therefor sleep clinic incorpor insomnia comisa manag pathway includ access cognit behavior therapi insomnia
|
D007319;D020181;D012891;D015928
|
T061;T184;T047;T048
|
36,333,078
|
best predictor continu posit airway pressur adher half continu posit airway pressur cpap treat patient adher substanti affect efficaci limit understand predictor adher lack singular definit univari analys suggest array factor statist signific reflect diseas pathophysiolog clinic featur demograph characterist devic relat variabl psycholog factor whether differ clinic meaning unclear limit applic multipl regress compar relat influenc multipl variabl review articl consid categori variabl explor suggest may label best predictor understand cpap use
|
D045422;D020181
|
T061;T047
|
36,333,077
|
use posit airway pressur treatment hypoventil treatment chronic hypoventil usual requir noninvas ventil howev upper airway obstruct lead hypoventil condit obes hypoventil syndrom chronic obstruct lung diseas overlap syndrom situat continu posit airway pressur effect therapeut option articl review pathophysiolog sleep relat hypoventil discuss situat treatment continu posit airway pressur feasibl briefli outlin noninvas ventil mode set treatment common sleep relat hypoventil disord
|
D010845;D063087;D029424
|
T061;T047
|
36,333,075
|
cost effect continu posit airway pressur therapi versus treatment obstruct sleep apnea obstruct sleep apnea osa common disord increas preval unit state worldwid continu posit airway pressur cpap gold standard treatment osa cost effect payer societ perspect altern treatment osa includ oral applianc therapi various surgeri hypogloss nerv stimul also evalu cost effect perspect although result less consist studi direct compar altern therapi cpap review discuss avail literatur cost effect analysi treatment osa
|
D020181;D019186
|
T061;T047
|
36,333,074
|
outcom data continu posit airway pressur treatment realli know obstruct sleep apnea one common chronic respiratori ill caus daytim sleepi cognit cardiovascular morbid success treatment posit airway pressur continu posit airway pressur bilevel posit airway pressur surpris difficult demonstr improv outcom continu posit airway pressur treatment may difficulti quantifi ill heterogen pathophysiolog clinic present articl review proven clinic outcom like complet proven
|
D020181;D006970
|
T033;T184;T047;T048
|
36,333,073
|
racial differ posit airway pressur adher treatment sleep apnea although data limit studi suggest averag lower posit airway pressur use black indigen peopl color bipoc compar white studi observ studi certain limit confound socioeconom status unmeasur factor like contribut differ etiolog observ dispar like multifactori due part financi limit differ sleep opportun poor sleep qualiti due environment disrupt forth dispar sleep health like relat chronic inequ includ experi racism neighborhood featur structur contextu factor dedic studi focus understand adher bipoc lack research need understand determin pap use bipoc subject identifi feasibl intervent improv sleep health reduc sleep apnea treatment dispar
|
D020181;D012891;D007319
|
T184;T047;T048
|
36,333,071
|
myeloprolif neoplasm adolesc young adult myeloprolif neoplasm mpns clonal stem cell disord common diagnos seventh decad life increas access blood surveil number adolesc young adult aya diagnos mpns increas aya repres uniqu cohort mpn patient differ challeng psychosoci need major aya patient femal diagnos essenti thrombocythaemia asymptomat diagnosi strike predisposit venous thrombot event signific number experienc splanchnic venous thrombosi venous event compar older patient aya appear indol diseas cours interferon prefer cytoreduct agent popul indic commenc treatment mirror older adult determin presenc high risk featur thromboembol event
|
D009369;D009196;D013920;D013927
|
T047;T191;T046
|
36,333,070
|
acceler blast phase myeloprolif neoplasm myeloprolif neoplasm mpn inher risk transform blast phase mpn bp acceler phase mpn ap character presenc peripher blood bone marrow blast respect primari myelofibrosi pmf associ highest risk blastic transform follow polycythemia vera pv essenti thrombocythemia et risk leukaem transform lt pmf determin three tier model base presenc idh mutat circul blast srsf mutat age year asxl mutat moderatesever anemia high intermedi low risk group lt incid respect current treatment mpn apbp includ acut myeloid leukaemia aml like induct chemotherapi hypomethyl agent alon combin venetoclax andor ruxolitinib transplant elig patient goal achiev complet remiss without count recoveri proceed allogen stem cell transplant modal associ long term surviv current review discuss diagnost prognost therapeut approach patient mpn apbp
|
D009196;D015470
|
T191
|
36,333,068
|
updat diagnost approach therapeut strategi system mastocytosi system mastocytosi rare diseas better recogn manag vast major patient indol diseas variabl symptom burden small proport evolv present aggress diseas may due increas mast cell burden leukem associ tumour mass common due presenc addit hematolog neoplasm sm ahn patient advanc system mastocytosi poor outcom howev recent advanc diagnosi molecular genet treatment chang prognost landscap group patient review address topic question relat diagnost classif new diseas entiti treatment multiparamet prognost score system
|
D034721;D019337;D054437
|
T191
|
36,333,067
|
challeng diagnos manag pre fibrot myelofibrosi case base practic approach pre fibrot myelofibrosi frequent recognis entiti distinct featur separ essenti thrombocythaemia overt primari myelofibrosi misdiagnosi relat common due subtl differ bone marrow trephin morpholog multidisciplinari approach requir clinic phenotyp diseas cours heterogen henc manag approach tend vari wide although patient may initi asymptomat diseas relat complic includ troublesom symptom burden increas incid arteri venous thrombos haemorrhag anaemia inher risk diseas evolut either overt myelofibrosi blastic phase diseas specif prognost tool high discriminatori power lack within review use case base approach review current literatur highlight challeng diagnost diseas manag suggest contemporari approach improv patient outcom
|
D055728;D013920
|
T047;T191
|
36,333,066
|
address symptom burden myeloprolif neoplasm patient myeloprolif neoplasm mpns suffer often debilit constitut symptom negat impact qualiti life degre similar patient metastat solid tumor despit heterogen breadth sever symptom mpns research symptom assess led creation well valid patient report outcom tool includ myeloprolif neoplasm symptom assess form total symptom score current avail pharmacolog therapi particular jak inhibitor result substanti reduct symptom burden patient myelofibrosi well select patient polycythemia vera essenti thrombocythemia non pharmacolog therapi includ yoga medit also investig review focus pathogenesi assess constitut symptom mpns detail current avail therapi address symptom burden highlight sever novel agent develop end discuss unmet need explor futur symptom assess treatment mpns
|
D009196;D009369
|
T191
|
36,333,065
|
consider comprehens care older individu myelofibrosi last decad wit massiv increas avail clinic agent clinic trial set follow commerci use approv direct reduc life expect well consider symptom splenic anaemia burden associ myelofibrosi given median age onset diseas coupl age popul global care increas age myelofibrosi cohort futur year need adapt approach emphas holist manag older individu myelofibrosi accord pharmacolog manag diseas consider need given intervent base concurr ill comprehens geriatr assess frailti polypharmaci drug drug interact nutrit issu psycholog concern depress anxieti distress cognit declin socialeconom aspect within review summaris avail data address issu outlin knowledg gap suggest summat holist approach older individu myelofibrosi
|
D055728
|
T191
|
36,333,064
|
contemporari futur strategi polycythemia vera polycythemia vera pv character clonal prolifer hematopoiet stem cell lead erythrocytosi patient pv signific higher morbid mortal compar general popul due increas risk thrombosi hemorrhag well character microvascular constitut symptom also propens transform myelofibrosi aggress form acut leukemia increas morbid mortal current manag aim reduc risk thromboembol event improv symptom burden howev none exist therapi proven abil deplet under malign clone definit reduc risk diseas progress leav larg area unmet need review highlight pathophysiolog pv current manag limit therein propos high debat clinic practic requir investig conclud discuss therapi develop may fill unmet need incorpor futur pv treatment paradigm
|
D011087;D055728
|
T191
|
36,333,063
|
transplant algorithm myelofibrosi beyond myelofibrosi mf chronic myeloprolif neoplasm heterogen clinic cours median surviv patient overt mf close year great individu variabl allogen hematopoiet cell transplant allo hct constitut curat treatment yet advanc age mf patient togeth signific transplant relat mortal limit applic procedur clinic practic less patient articl review current indic allo hct mf factor consid select candid procedur end describ prognost tool develop predict surviv mf patient manag convent pharmacolog therapi allo hct summar main result allo hct review practic aspect procedur discuss optim time particular relat jak inhibitor treatment
|
D055728;D018380
|
T061;T191
|
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