PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,223,955 | tripartit antigen agnost combin immunotherapi cure establish poor immunogen tumor singl agent immunotherapi shown remark efficaci select cancer entiti individu patient howev patient fail respond like due divers immunosuppress mechan act concert way suppress host anti tumor immun respons combin immunotherapi approach effect poor immunogen tumor most reli precis knowledg antigen determin tumor cell creat antigen agnost combin immunotherapi effect poor immunogen tumor antigen determin known major challeng | D009369;D051196 | T191;T116;T192 |
36,223,937 | robot thorac surgeri canada patient will pay pocket robot assist thoracoscop surgeri rts safe effect associ high capit oper cost reimburs canadian govern current patient access rts support research philanthrop fund recent studi assess extent patient report satisfact rts whether patient would will pay pocket factor associ patient willing pay mani patient state would paid addit supplement govern health care coverag access rts factor found signific associ particip willing pay annual incom p privat insur coverag p overal experi rts rate higher p overal postop postdischarg experi rate satisfi satisfi p | D065287;D013903 | T061;T091 |
36,223,936 | covid durat oper room procedur ontario popul base retrospect studi studi estim larg backlog procedur generat emerg measur implement ontario canada onset covid pandem nonessenti schedul procedur postpon understand impact covid pandem time need perform procedur may help determin resourc need tackl substanti backlog caus deferr case purpos studi examin durat oper room procedur onset covid pandem inform plan around chang requir resourc | D000086382 | T047;T067 |
36,223,935 | trend liver transplant autoimmun liver diseas canadian studi knowledg analysi data liver transplant registri exist canada aim describ tempor trend number liver transplant procedur patient characterist posttransplant outcom autoimmun liver diseas aild canada | D015209;D019693;D008105;D008107;D016031 | T061;T047;T033 |
36,223,934 | donat transplant coverag canadian media content analysi stori focus decad media coverag affect polici debat around organ donat transplant perform content analysi stori canadian popular press focus organ donat transplant built data set articl publish jan may includ articl assess headlin lead paragraph determin stori focus tone common topic recipi donor polici rais awarenessfund tone articl posit neutral negat strong focus patient report may cloud critic polici discuss health communic polici maker continu assess creat engag messag remain accur | D016377;D009927 | T073;T061;T058;T055;T033 |
36,223,933 | multi omic approach reveal featur permit robust widespread regul ifn induc antivir effector antivir state initi line defens viral infect establish set ifn stimul gene isg encod antivir effector protein effector isg transcript regul type ifn main via activ ifn stimul gene factor isgf studi regulatori element effector isg character determin epi genet featur enabl robust induct type ifn multipl cell type determin locat regulatori element dna motif occup isgf subunit irf stat stat transcript factor chromatin access effector isg murin dendrit cell ifn stimul respons element isr tripartit version occur frequent regulatori element effector isg test isg subset chromatin access promot region similar isg higher promot inflamm relat cytokin use refer gene set effector isg least one isgf bind region proxim transcript start site tss subset effector isg associ three isgf bind region irf signal typic higher isr motif stronger similar canon sequenc tss proxim versus tss distal regulatori region moreov tss proxim regulatori region access stimul multipl cell type result indic strong isr motif univers access promot region permit robust widespread induct characterist featur effector isg | D000090103;D020218 | T123;T116;T114 |
36,223,932 | trim regul virus induc cell pyroptosi polyubiquitin isga pyroptosi form regul cell death mediat gasdermin protein famili virus infect cell pyroptosi restrict viral replic mechan tripartit motif trim protein famili ifn stimul gene isg virus studi role trim isg pyroptosi remain unclear studi show trim interact isga viral infect facilit transloc mitochondria promot ubiquitin therebi caus caspas activ gasdermin e gsdme specif cleav caspas upon viral infect releas gsdme n termin domain perfor cell membran caus cell pyroptosi studi uncov new mechan trim isga regul virus induc cell pyroptosi | D000069292;D014780 | T043;T005 |
36,223,930 | histamin releas factor novel alarmin induc hous dust mite allergen cytokin cell death histamin releas factor hrf multifunct protein fundament intracellular function control cell surviv prolifer hrf also secret allerg reaction promot ige mediat activ mast cell basophil studi investig hrf secret relev airway inflamm hrf monom constitut secret bea b human bronchial epitheli cell hbec convert oligom cours cultur stimul hous dust mite hdm extract increas hrf secret substanti sever cytokin involv asthma pathogenesi show moder effect hrf secret dramat enhanc hdm induc hrf secret hdm induc hrf secret bea b cell normal hbec proceed via tlr consist multipl tlr ligand includ der p der p der p der p induc hrf secret der p tropomyosin also promot hrf secret cell death incub adenosin atp compound releas upon cell death also enhanc hrf secret furthermor intranas administr recombin hrf elicit robust airway inflamm hdm sensit mice fcri depend manner therefor conclud hrf novel alarmin promot allerg airway inflamm | D000067531;D016207 | T123;T116;T129 |
36,223,920 | genom wide associ studi egfr taiwanes popul chronic kidney diseas ckd global public health issu associ larg econom burden ckd contribut higher risk cardiovascular complic kidney failur mortal incid preval rate kidney failur taiwan remain highest world | D055106;D051436 | T047;T063 |
36,223,918 | women attitud toward human papillomavirus base cervic cancer screen strategi systemat review provid insight women attitud toward human papillomavirus hpv base cervic cancer screen strategi | D052685;D030361;D002583 | T191;T047;T005 |
36,223,880 | whole exom sequenc identifi olfactori receptor gene key contributor extrem obes progress nonalcohol steatohepat mexican patient olfactori receptor gene obes nash patient obes global health problem trigger fat liver accumul preval obes risk non alcohol steatohepat nash among young obes mexican high furthermor genet predisposit key factor weight gain disrupt metabol herein use whole exom sequenc identifi potenti causal variant biolog process lead obes progress nash among mexican patient | D065626;D018035 | T047;T116;T192 |
36,223,868 | develop va geriatr scholar program clinic dashboard use pdsa framework qualiti improv involv clinician end user develop process clinic dashboard import ensur user need adequ met prior releas dashboard use challeng follow approach clinician end user undergo period turnov mean clinician play role initi develop process may individu use dashboard futur | D058996;D058028 | T057;T170 |
36,223,867 | recent advanc applic lignin nanoparticl function composit mini review recent year lignin nanoparticl lnp gain tremend deep research field function composit mani advantag abund non toxic afford green eco friend biodegrad biocompat featur along antioxid antibacteri uv absorb abil present numer pioneer work devot develop lnp base composit multipl function herein comprehens review latest research progress correl lnp fill function composit overview focus applic lnp reinforc crosslink uv protect antioxid antimicrobi adhes agent function composit addit challeng futur outlook exploit util lnp function composit discuss | D008031;D053758 | T109;T123;T073 |
36,223,866 | new hyper thermost carboxylesteras anoxybacillus geothermali carboxylesteras attract biocatalyst various industri applic especi hyperthermophil carboxylesteras due high toler toward extrem environ abil confer mani advantag includ cost effect increas manufactur rate current work first describ character estd new carboxylesteras thermophil anoxybacillus geothermali sequenc analysi estd reveal signific ident thermophil est catalyt triad compos ser asp protein sequenc contain conserv pentapeptid glslg estd could propos new member famili xiii putat carboxylesteras recombin express e coli bl de molecular mass kda success purifi via affin chromatographi recoveri use p nitrophenyl butyr estd present excel stabil high temperatur rang c c broad ph toler ph optim activ c ph notabl estd activ stimul presenc propanol dmso relat activ respect purifi estd maintain residu activ min exposur various surfact metal ion addit inhibit studi demonstr strong deactiv phenylmethylsulfonyl fluorid dithiothreitol mercaptoethanol estim tm valu c unlik typic carboxylesteras silico model estd disclos topolog hydrolas fold small helix cap enzymat properti estd suggest enzym high suitabl catalyst industri bioprocess harsh condit | D043182;D004926 | T007;T126;T116 |
36,223,864 | lumbrokinas regul endoplasm reticulum stress improv neurolog deficit ischem stroke ischem stroke character loss cerebr blood flow frequent lead neurolog deficit tissu plasminogen activ therapeut agent approv treat ischem stroke increas risk intracrani hemorrhag mortal fibrinogen deplet agent lumbrokinas use improv myocardi perfus symptomat stabl angina prevent secondari ischem stroke lumbrokinas high fibrin specif activ presenc fibrin therefor lumbrokinas low risk hemorrhag due excess fibrinolysi studi aim clarifi neuroprotect lumbrokinas mice subject perman middl cerebr arteri occlus lumbrokinas signific attenu infarct volum improv neurolog dysfunct lumbrokinas dramat decreas express endoplasm reticulum er transmembran receptor protein inositol requir enzym ire downstream transcript factor xbp caspas nf b activ therebi signific inhibit apoptosi autophagi decreas nlrp inflammasom evid indic post stroke treatment lumbrokinas protect ischem stroke therebi regul er stress collect inhibitori effect ire signal pathway decreas apoptosi autophagi inflammatori respons suggest lumbrokinas potenti adjuv treatment ischem stroke | D000083242;D002545 | T047;T046 |
36,223,856 | cryogrind siev techniqu challeng toward produc control size rang microplast relev ecotoxicolog test impact microplast mp attract much attent scientif communiti mani laboratori assess made effect aquat organ produc mp real environment plastic wast would enabl realist experi use plastic pearl farm equip french polynesian lagoon pearl oyster pinctada margaritifera could encount mp come breakdown surround environ test establish method base mechan cryogen grind liquid siev desir size rang correspond optim particl size ingest p margaritifera protocol effect generat mp particl mp g also produc mani smaller particl peak desir size rang thus flatten mani small particl mp g total analys particl visibl limit coulter counter analysi cut point laser diffract analysi cut point provid greater detail show total analys particl diverg particl size distribut expect base siev rang realli observ highlight need perform fine scale particl size distribut analys avoid underestim number small micro nanoplast mnp obtain exact estim fraction produc size microstructur character scan electron microscopi suggest spontan particl self assembl crystal superstructur suppos caus diverg observ overal result emphas particl self assembl technic hurdl requir work highlight specif need fine character size distribut mnp use ecotoxicolog experi avoid overestim effect | D049911;D014874 | T131;T204 |
36,223,855 | quantif enhanc voc emiss firework firework wide use celebr worldwid effect firework physicochem characterist atmospher particl well document howev influenc firework burn ambient volatil organ compound voc emiss remain unclear determin impact firework burn event voc emiss ambient voc measur receptor site fenwei plain chines spring festiv period firework burn plume identifi use potassium ion k tracer twenti voc speci obtain firework tracer emiss ratio voc speci relat k rang g g first estim linear fit method sourc tracer ratio method voc contribut firework burn lantern festiv higher level chines new year daytim net ozon format rate spring festiv lantern festiv increas respect averag due firework emiss secondari organ aerosol format potenti soap increas averag respect result provid sourc tracer firework subsequ help assess impact region air qualiti public health | D055549;D000393;D000397 | T069;T109;T131;T080 |
36,223,854 | multipl reaction monitor mass spectrometri discoveri environment modul protein aquat invertebr sentinel speci gammarus fossarum multipl reaction monitor mrm mass spectrometri emerg relev tool measur custom molecular marker freshwat sentinel speci techniqu typic use valid protein molecular marker preselect shotgun experi recent gain mrm multiplex capac offer new possibl conduct larg scale screen anim proteom combin strength activ biomonitor strategi mrm technolog studi aim propos new strategi discoveri candid protein respond environment variabl purpos peptid deriv protein monitor mrm male gammarid cage environment site repres divers french water bodi methodolog propos identifi set custom housekeep peptid hkps use correct analyt batch effect allow proper comparison peptid level gammarid compar analysi perform hkps normal data result identif peptid high modul environ deriv protein like involv environment stress respons overal studi propos breakthrough approach screen identifi potenti protein respond relev environment condit sentinel speci | D000072739;D033304 | T001;T008;T002;T204 |
36,223,853 | respons soil protist antimoni arsenic contamin microorgan mediat antimoni sb arsenic transform thus chang mobil toxic similar geochem behavior sb general consid exert similar environment pressur microbiom howev need valid especi protist studi respons protistan communiti sb investig collect soil xikuangshan sb mine shimen mine china antimoni contamin taxonom function consum phototroph chang alpha beta divers protistan communiti exert differ impact parasit communiti base multipl statist tool contamin greater impact protistan communiti sb ecolog network high contamin site less complex high posit connect compar less contamin site high contamin rais ratio consum decreas ratio phototroph ecolog network opposit tendenc observ sb contamin soil high sb contamin enrich differ keyston taxa resist sb result demonstr protistan communiti respond differ sb | D001151;D012989 | T121;T131;T196 |
36,223,852 | silicon oxid nanoparticl allevi chromium toxic wheat triticum aestivum l increas chromium cr contamin agricultur soil threat crop yield qualiti recent nano enabl strategi emerg great potenti toward improv crop product reclaim heavi metal contamin soil studi aim elucid potenti silicon oxid nanoparticl sionp optim wheat growth yield cr stress induc phytotox spheric crystallin sionp diamet rang nm appli dose mg kg soil pot experi plant wheat seedl without cr contamin pot experi result show sionp amend signific improv plant length fresh dri weight compar control treatment addit sionp also enhanc photosynthet activ antioxid enzym content cat apx sod pod content reduc reactiv oxygen speci ros wheat plant cr stress condit allevi cr toxic deem associ reduc cr uptak root shoot ultrastructur analys reveal applic sionp cr contamin soil maintain normal cellular structur wheat plant compar control without sionp result provid first evid show great potenti sionp applic toward allevi cr stress optim wheat growth yield cr contamin soil | D012989;D053758 | T131;T073 |
36,223,851 | multi biomark approach assess toxic diclofenac oh diclofenac mytilus trossulus mussel first evid diclofenac metabolit impact mollusc although presenc pharmaceut environ issu wide address research past two decad still littl known transform product howev indic chemic may equal even harm parent compound diclofenac dcf among common detect pharmaceut aquat environ potenti effect metabolit organ poor understood therefor present studi aim evalu compar toxic dcf metabolit hydroxi diclofenac oh dcf mussel use multi biomark approach mytilus trossulus mussel expos dcf oh dcf gl measur concentr day respect day work show test compound effect enzymat biomark test howev shown action affect protein content gill also reflect histolog marker environment implic studi recent year clear prove pharmaceut negat affect aquat organ addit parent compound metabolit pharmaceut also signific environment problem present work effect diclofenac main metabolit hydroxi diclofenac marin mussel evalu compound show negat effect mussel primarili observ histolog chang present studi therefor confirm diclofenac also main metabolit negat effect aquat organ | D049878;D014874 | T131;T204 |
36,223,847 | potenti anti arthrit analges properti essenti oil viridiflorol obtain allophylus eduli leav mice viridiflorol identifi isol essenti oil allophylus eduli leav eoae eduli use terer drink made infus herb cold water treat pain toothach headach anti nocicept analges anti arthrit properti eoae viridiflorol complet scientif clarifi | D009822 | T109 |
36,223,846 | screen medicin plant possibl herb drug interact modul nuclear receptor drug metabol enzym transport last three decad wit surg popular consumpt herbal product unintend consequ popular chronic consumpt product often modul function various protein involv drug disposit may turn impos risk herb drug interact hdis lead serious advers health outcom identifi plant may give rise clinic relev hdis essenti proactiv dissemin research outcom necessari research clinician averag consum | D010946;D011987 | T116;T002;T192 |
36,223,845 | proteom reveal di dang decoct regul jakstat signal pathway inhibit apoptosi reduc oxid stress respons rat acut intracerebr hemorrhag stroke di dang decoct ddd prescript use treatment cerebr hemorrhag use deriv theori typhoid fever obvious clinic effect use clinic long time result earli quantit proteom target proteom studi show administr high dose ddd day may regul express protein sa sa cola cola first day bleed begin critic period intervent occur within approxim day aich unclear | D000083302;D020521 | T047 |
36,223,844 | kaempferol rutinosid antidesma acidum retz stimul glucos uptak sirt induct follow glut transloc skelet muscl l cell antidesma acidum retz perenni herb known anti diabet potenti among tradit health care provid tribal communiti manipur india scientif valid ancient knowledg tradit use plant help modern tool techniqu promot research use health care | D056564;D003924 | T047;T126;T116 |
36,223,843 | qi jing mingmu decoct inhibit p signal pathway conjunctivochalasi fibroblast regul th cell differenti qi jing mingmu qjmm decoct tradit chines medicin wide use clinic treatment conjunctivochalasi cch effect treatment reliev ocular symptom includ improv tear film promot tear secret howev effect molecular mechan need elucid | D003229;D020381 | T047;T116;T192;T123;T129 |
36,223,842 | antiplasmodi antimalari evalu nigerian hepta herbal agbo iba decoct identif magic bullet possibl facilit drug action malaria remain one import pathogen infecti diseas although africa suffer greatest brunt sizeabl proport popul still reli herbal medicin reason cost well belief etch mind consum herbal medicin safer efficaci modern medicin agbo iba concoct two two plant common use manag malaria nigeria | D000962;D008288;D010946 | T121;T047;T002 |
36,223,841 | artifici light night alter diurnal nocturn behavior physiolog green anol lizard artifici light night alan disrupt biolog rhythm across wide divers organ determin energi alloc anim differ light environ investig impact alan behavior physiolog diurnal green anol lizard anoli carolinensi two group adult lizard half male half femal maintain control lab set six week one group expos simul natur summer light dark cycl expos alan simul urban nocturn light exposur acclim period conduct four behavior trial one trial examin behavior time alloc two h period three other conduct mid day mid night open field test examin exploratori behavior forag trial examin prey consumpt social interact trial examin sex interact measur lizard snout vent length mass bodi abdomin fat pad liver male test lizard expos alan like awak night use nocturn light explor forag display conspecif howev day alan lizard less like awak slower move femal display less frequent alan lizard heavier fat pad test alan impact bodi mass liver mass snout vent length sum alan appear caus broad shift toward increas nocturn activ may alter metabol reproduct process futur work examin fit consequ behavior physiolog chang | D008116 | T014 |
36,223,840 | rna seq studi mpfc rat differ addict phenotyp addict diseas brain reward circuitri wherebi attent motiv memori emot system becom enslav goal seek acquir drug instead respond natur reward system evolv intersect rewardlimb structur medial prefront cortex mpfc receiv consolid signal regard environ orchestr appropri respons ie decis make attent mpfc function play critic role vulner resili drug addict model drug induc reward devalu outbr group spragu dawley rat pars two distinct drug take phenotyp refer small suppressor ss readili ingest heroin pair sweet cue take littl drug refer larg suppressor ls avoid heroin pair cue respond great drug abus present studi analyz mpfc transcriptom rat diverg group discov differ gene express underli distinct phenotyp gene found differenti express associ schizophrenia dopamin signal signal transduct develop synapt plastic gene may underli circumst wherebi individu succumb addict other may reveal new pharmacolog target treatment drug addict | D003932;D017397 | T023;T030;T131;T029;T121;T109 |
36,223,839 | protobor alkyn miyaura boryl catalyz low load palladium version miyaura boryl protobor alkyn catalyz low load palladium mol ppm mol develop transform broad substrat scope good function group compat gram scale synthet abil | D010165;D000480 | T109;T196 |
36,223,827 | size depend effect nanoplast structur function superoxid dismutas ubiquit exist nano plastic nps attract widespread concern current uptak nps organ cell report howev knowledg interact nps protein still limit gap research size depend toxic nps toward protein studi multi spectroscop techniqu enzym activ determin use explor structur function chang main antioxid enzym superoxid dismutas sod caus bind nps differ particl size result indic nps differ size direct interact sod nps smaller size result looser skeleton sod larger lead tighter peptid chain addit nps bind sod form complex smaller nps easier induc coalesc sod surfac curvatur nm nps conduc vari secondari structur sod nps nm nm caus greater sensit sod endogen fluoresc increas polar around tyrosin residu enzym activ assay reveal function differ caus size depend effect nps nps nm nm induc signific chang sod activ increas respect nps nm nm littl impact togeth smaller nps greater impact structur function sod studi reveal size depend toxic nps protein provid rational necessari avoid substitut nps engin applic | D000080545;D053758 | T073;T122 |
36,223,826 | optim phototherm convers catalyt site photo assist catalyt degrad volatil organ compound solar energi convers promis strategi enhanc elimin volatil organ compound voc minim power consumpt herein non nobl metal wc wo cocatalyst composit ceo optim photochem phototherm convers catalyt ozon toluen aceton phototherm convers effici visibl infrar light wc wo ceo time higher ceo respect indic equilibrium temperatur catalyst remark increas full spectrum light irradi moreov wc wo transfer electron ceo wc wo ceo thus remark improv activ catalyt site synergi factor light wc wo ceo reaction rate toluen aceton reach mg min respect work provid low cost high effici catalyst util solar energi voc control | D055549 | T109 |
36,223,825 | optim spatial interpol method sampl number predict cadmium distribut largest shallow lake north china cadmium cd pollut wide recogn lake ecosystem although accur predict spatial distribut cd lake import control cd pollut tradit monitor method set discret limit sampl point actual reflect continu spatial distribut characterist cd studi set sampl point baiyangdian lake bydl collect surfac water over water sediment sampl sampl point cd content measur predict spatial distribut differ environment compon three interpol method invers distanc weight idw radial basi function rbf ordinari krige ok effect differ sampl number interpol accuraci also assess optim interpol method sampl number result show interpol accuraci idw decreas increas power valu best basi function rbf imq best semivariogram model ok spheric model stabl model best interpol method water sediment rbf imq compar ok idw within sampl number rang interpol accuraci cd surfac water increas increas sampl number compar interpol accuraci highest over water sediment sampl number find work provid combin sampl spatial interpol method monitor spatial distribut pollut level cd water sediment shallow lake | D060106;D002104 | T131;T196;T083;T070 |
36,223,824 | rethink intraparticl diffus adsorpt kinet model interpret solv method applic adsorpt wide use unit process various field chemic environment pharmaceut etc intraparticl diffus adsorpt kinet model one wide use adsorpt kinet model howev applic solv method model yet discuss model two form q kt q kt constant q adsorpt capac time k constant model paramet unifi yet moreov interpret kinet model lack theoret basi line pass origin point adsorpt domin intraparticl diffus multipl adsorpt process studi analyz proper equat intraparticl diffus model applic discuss interpret mass transfer step reveal model provid solv method result indic piecewis function q k q q k proper form model adsorb diffus pore insid adsorb mass transfer step reveal model statist paramet use evalu fit result instead judg whether model line pass origin point provid solv method use origin microsoft excel softwar solv model studi establish method applic intraparticl diffus model | D010825 | T090 |
36,223,823 | time magnitud anthropogen mercuri pollut year record multi lake sediment core northeast china recent substanti expans human activ northeast ne china result increas emiss environment pollut longer term record environment pollut provid benchmark possibl evalu natur extent time anthropogen environment chang base measur mercuri hg concentr accumul rate lake sediment core songnen plain ne china present reconstruct histor deposit hg indic chang scale human impact result demonstr increas trend hg concentr concurr elev anthropogen emiss begin earli acceler mid slight decreas late onward increas anthropogen hg coincid reform open china precipit social econom transform rapid industri econom growth measur hg enrich factor core enabl identif anthropogen contribut hg accumul geoaccumul index indic lake general moder pollut hg histor trend hg accumul rate parallel tempor progress biomass burn fossil fuel consumpt region find elucid extent anthropogen pollut anthropocen underlin import identifi hg sourc reduc emiss guid implement effect mitig strategi | D008628;D014874 | T131;T196 |
36,223,822 | toxic respons freshwat microalga chlorella sorokiniana due exposur flame retard flame retard tetrabromobisphenol tbbpa tris dichloro propyl phosphat tdcpp tributyl phosphat tbp frequent detect surfac water howev effect frs exposur aquat organ especi freshwat microalga still unclear studi toxic tbbpa tdcpp tbp microalga chlorella sorokiniana term growth inhibit photosynthet activ inhibit oxid damag investig accord ecolog risk assess result show tbbpa tdcpp tbp inhibitori effect c sorokiniana h ec concentr maxim effect valu mgl respect fvfm decreas increas exposur time mgl tbbpa mgl tdcpp mgl tbp exposur fvfm decreas signific h howev fvfm rose h indic damag photosynthet activ revers content chlorophyl decreas increas tbbpa concentr mgl howev chlorophyl increas first decreas increas tdcpp tbp concentr mgl mgl respect result indic c sorokiniana could use phosphorus tdcpp tbp ensur product chlorophyl risen content reactiv oxygen speci malondialdehyd well superoxid dismutas activ indic exposur frs induc oxid stress addit risk quotient show test frs ecolog risk natur water wastewat studi provid insight toxicolog mechan differ frs toward freshwat microalga better understand accord environment risk | D005411;D058086;D002708 | T120;T002;T204 |
36,223,821 | aggreg natur inorgan colloid aqueous environ review natur inorgan colloid nic common domin exist ecosystem high concentr wide varieti spite low toxic alter activ mobil hazard engin nanoparticl enp differ interact warrant necess understand predict fate transport nic aquat ecosystem review summar nic properti behavior interact mechan environment factor first time various repres nic physicochem properti introduc across board aggreg sediment behavior discuss systemat main concern heteroaggreg nic enp specul fate elucid correspond mechan classic derjaguin landau verwey overbeek dlvo extend dlvo x dlvo theori focus furthermor rang intrins extrins factor present differ perspect last least paper point theoret analyt gap current research put forward suggest research aim provid comprehens origin perspect field natur occur colloid | D017753;D053758 | T082;T073;T070 |
36,223,820 | histolog metabonom reveal toxic effect kresoxim methyl adult zebrafish studi shown kresoxim methyl km strobilurin fungicid toxic effect aquat organ howev potenti deleteri effect kresoxim methyl km adult zebrafish regard ecolog risk environment concentr remain unclear histolog untarget metabonom use investig advers effect femal zebrafish exposur km environment concentr aquat life benchmark one half lc adult zebrafish result demonstr km affect zebrafish liver ovari intestin develop blur boundari hepatocyt caus hepat vacuol increas percentag perinucleolar oocyt cortic alveolus oocyt decreas intestin goblet cell disturb villus wall integr exposur metabonom show differ concentr km simultan influenc metabolit annot vitamin digest absorpt serotonerg synaps retinol metabol ovarian steroidogenesi arachidon acid aa metabol zebrafish liver result show decreas triglycerid cholesterol level well metabol alter amino acid lipid vitamin retinol metabol caus km might disturb energi suppli normal liver develop oocyt matur addit km alter transcript tdoa tdob ido cxclb cypa cypa cypb cypa cypa hsd hsd pla ptgsa ptgsb level tg tc mda ifn il ca activ cat sod ca atpas zebrafish liver moreov cytoscap analysi suggest disturb aa metabol caus km might interconnect multipl metabol pathway share implic function regul oocyt matur immun respons current studi brought us closer increment understand toxic mechan km adult zebrafish indic crosstalk among differ regulatori pathway regul metabol disord biolog hazard effect induc km | D005659;D014874 | T131 |
36,223,782 | histor evolut new trend soil intrud interact model soil crucial resourc life earth everi activ whether natur man made interact sub deep soil affect land larg scale eg geolog risk understand interact help identifi sustain less invas soil penetr explor monitor solut year multipl approach use model soil mechan reveal soil behavior paper review differ model techniqu use simul interact penetr tool soil follow use time open analyt method discuss limit partial overcom finit element method fem fem model capabl simul complex condit geometri howev requir continuum mechan assumpt henc fem analysi simul discret process occur soil deform ie separ mix soil layer appear crack flow soil particl discret element method dem thus adopt promis model techniqu alongsid model experiment approach also use describ soil intrud interact complement valid simul result recent bioinspir approach consid promis improv sustain reduc invas classic penetr strategi review highlight dem base model help studi interact mechan bioinspir root like artifici penetromet soil bioinspir design merg multipl analysi approach offer new perspect may pivot design high optim soil robot explor capabl adapt morpholog penetr strategi base surround condit | D012987;D012371 | T090;T167 |
36,223,777 | transcriptom base network medicin approach identifi metformin repurpos drug atrial fibril effect drug atrial fibril af lack result signific morbid mortal studi demonstr network proxim analysi differenti express gene atrial tissu drug target help priorit repurpos drug af use enrich analysi drug gene signatur function test human induc pluripot stem cell ipsc deriv atrial like cardiomyocyt identifi metformin top repurpos drug candid af use activ compactor new design analysi larg scale longitudin electron health record ehr data determin metformin use signific associ reduc risk af odd ratio confid interv ci p compar standard treatment diabet studi util network medicin methodolog identifi repurpos drug af treatment identifi metformin candid drug | D001281;D008687 | T121;T047;T046;T109 |
36,223,776 | slide motor tail cargo surfac due drift diffus affect team arrang collect transport kinesin microtubul associ motor protein work team carri cellular cargo transport lipid raft membran cargo reorgan caus motor present area physic cluster unregul cluster motor lead diseas leishmaniasi newmann pick diseas etc various vitro comput studi report improv cargo veloc travel distanc fluid cargo compar rigid cargo howev cargo veloc increas increas membran fluiditi fluid cargo thermal motor forc act tangenti cargo generat random torqu motor torqu respect lead cargo rotat motor tail slide cargo surfac howev unknown forcestorqu play crucial role improv transport properti use comput model incorpor random torqu motor torqu combin random motor torqu understand influenc cluster kinesin motor cargo surfac due drift diffus tail studi perform vari tail diffus understand effect cluster tail dispers cluster arrang find dispers arrang random torqu caus cluster wherea motor torqu crucial cluster tail cargo surfac tail slide due random motor torqu fastest cargo transport maximum cooper cluster arrang tail slide form broad steadi cluster whose size increas tail diffus result decreas cargo runlength veloc cooper find suggest increas tail diffus negat impact cluster cargo transport tail cluster arrang wherea aid physic cluster tail cargo transport dispers arrang | D016547;D008870 | T126;T026;T123;T116 |
36,223,774 | reduc b cell antigen omicron lower host serolog respons sar cov omicron variant evad neutral vaccin induc antibodi associ lower antibodi titer upon breakthrough infect previous variant howev mechan remain unclear find use geometr deep learn model omicron extens mutat receptor bind site rbs featur reduc antigen compar previous variant mice immun experi differ recombin receptor bind domain rbd variant confirm serolog respons omicron drastic attenu less potent analys serum cross reactiv competit elisa reveal reduct antibodi respons across variabl conserv rbd epitop comput model confirm rbs potenti antigen reduct retain effici receptor bind final find similar trend antigen reduct decad hcove common cold coronavirus thus studi explain reduc antibodi titer associ omicron infect reveal possibl trajectori futur viral evolut | D014765;D000086382 | T121;T047;T067;T129 |
36,223,773 | laboratori perform von willebrand diseas diagnost classif von willebrand diseas patient result extern qualiti data intern survey reduc dysfunct von willebrand factor vwf may lead von willebrand diseas vwd common inherit bleed disord vwd classifi three major type type partial quantit defici vwf type complet quantit defici vwf type consist qualit abnorm vwf arriv correct vwd diagnosi multipl test correct interpret test need | D056725;D014842 | T047 |
36,223,772 | analysi colleg american pathologist von willebrand factor profici test program von willebrand factor vwf level andor function alter von willebrand diseas vwd common herit bleed disord worldwid laboratori assess vwf continu evolv histor primari method assess vwf platelet bind activ ristocetin cofactor assay vwf rco contemporari altern measur vwf platelet bind activ includ vwf gpibr recombin use ristocetin vwf gpibm recombin gain function mutant monoclon antibodi recent american societi hematolog intern societi thrombosi haemostasi nation hemophilia foundat world feder hemophilia collabor issu guidelin recommend use newer assay vwf platelet bind activ vwf gpibm vwf gpibr vwf rco given known limit vwf rco assay despit recommend newer vwf gpibm vwf gpibr assay unit state food drug administr clear limit avail unit state sought assess assay util trend agreement vwf test method imprecis vwf test base assign sampl type colleg american pathologist profici test survey analysi confirm vwf antigen test low imprecis various vwf activ assay signific interassay variabl vwf rco show greater imprecis newer gpib bind assay overal trend assay util reflect barrier complet complianc modern vwd diagnost guidelin north america | D006467;D014842 | T047 |
36,223,771 | laboratori test evalu phenotyp activ protein c resist activ protein c apc resist apcr consid risk factor venous thromboembol vte common genet disord confer apcr factor f v leiden mutat mani factor also implic f mutat eg fv hong kong fv cambridg protein defici elev factor viii exogen hormon use pregnanc postpartum depend apcr defin consid larg popul affect detect phenotyp crucial two type test current avail clot time base assay sever version thrombin generat base assay endogen thrombin potenti etp base assay purpos review therefor discuss perform test case would appropri use one initi apcr thought sole relat fv leiden mutat object obtain specif assay clot time base assay thus specif design detect inherit condit later apcr condit without fv leiden mutat identifi highlight independ risk factor vte therefor develop less specif assay need global coagul test propos known etp base apcr assay light test use purpos clot time base assay recommend screen test detect fv mutat prior confirm genet test hand etp base apc resist assay addit abl detect type apcr could propos global screen test assess entir coagul process | D020016;D054556 | T047 |
36,223,768 | gift new method genet analysi small gene effect involv small sampl size small gene effect involv complexomnigen trait remain cost analys use current genom wide associ studi gwas number individu requir return meaning associ aka studi power inspir field theori physic provid differ method call genom inform field theori gift contrast gwas gift assum phenotyp measur precis enough andor number individu popul small permit creation categori extract inform gift use inform contain cumul sum differ gene microst two configur individu taken random without inform phenotyp valu ii individu rank function phenotyp valu differ cumul sum attribut emerg phenotyp field demonstr gift recov gwas fisher theori phenotyp field linear first order howev unlik gwas gift demonstr varianc microst distribut densiti function also involv genotyp phenotyp associ phenotyp field quadrat second order use genotyp phenotyp simul base fisher theori toy model illustr applic method small sampl size individu | D055106;D020641 | T063;T086 |
36,223,763 | extra cardiac bcaa catabol lower blood pressur protect heart failur pharmacolog activ branch chain amino acid bcaa catabol protect model heart failur hf protect occur remain unclear although causat block cardiac bcaa oxid wide assum use vivo isotop infus show cardiac bcaa oxid fact increas rather decreas hf moreov cardiac specif activ bcaa oxid protect hf even though system activ lower plasma cardiac bcaa also fail confer signific protect suggest altern mechan protect surpris activ bcaa catabol lower blood pressur bp known cardioprotect mechan bp lower occur independ nitric oxid reflect vascular resist adrenerg constrict mendelian random studi reveal elev plasma bcaa portend higher bp human togeth data indic bcaa oxid lower vascular resist perhap part explain cardioprotect hf mediat direct cardiomyocyt | D000597;D006333 | T047;T046;T123;T116 |
36,223,761 | particl swarm fit spin hamiltonian magnet circular dichroism reduc bound flavodiiron protein particl swarm optim pso algorithm describ fit ground state spin hamiltonian paramet variabl temperaturevari field vtvh magnet circular dichroism mcd data pso algorithm employ defin ground state two catalyt intermedi flavodiiron protein fdp class enzym nitric oxid reductas activ bimetal iron activ site enzym proceed biferr intermedi mix ferrous feno intermedi catalyt cycl mcd spectra intermedi present analyz fit spin hamiltonian shown provid import geometr electron insight speci compar contrast previous report | D007501;D060328 | T121;T070;T123;T196 |
36,223,760 | interpret mental state decod deep learn model mental state decod research aim identifi set mental state eg experienc happi fear reliabl identifi activ pattern brain region network deep learn dl model high promis mental state decod unmatch abil learn versatil represent complex data howev widespread applic mental state decod hinder lack interpret difficulti appli small dataset ensur reproduc robust recommend approach challeng leverag recent advanc explain artifici intellig xai transfer learn also provid recommend improv reproduc robust dl model mental state decod | D001185;D001931;D000077321 | T073;T060;T066;T090;T062 |
36,223,759 | studi paraquat induc pulmonari fibrosi use biomimet micro lung chip paraquat pq poison induc pulmonari fibrosi vivo pathogenesi pulmonari fibrosi complex prevent develop specif treatment pulmonari fibrosi show sever characterist includ epitheli mesenchym transit emt fibroblast activ extracellular matrix ecm deposit investig pulmonari fibrosi design biomimet multichannel micro lung chip imit vivo interfac lung epithelium lung interstitium model lung epitheli cell mrc fetal lung fibroblast cell use test efficaci chip base model rat tail type collagen hyaluron acid use simul ecm provid microenviron micro lung chip cultur pq viabil mrc cell signific decreas increas pq concentr signific chang surfact protein c sp c alpha smooth muscl actin protein sma vimentin protein level pq induc pulmonari fibrosi sp c level decreas cell sma vimentin increas cell mrc cell treat pq micro lung chip also design refer model without interact lung epitheli cell fibroblast compar non contact model co cultur mrc cell chip induc sever emt cell treatment pq togeth defend pq induc damag thus novel co cultur micro lung chip model lung epithelium interstitium may provid new approach studi lung fibrosi facilit drug develop | D010269;D011658 | T047;T109;T131 |
36,223,754 | differenti dynam respons c elegan chemosensori cilia cilia membran envelop organell protrud surfac eurokaryot cell play crucial role sens extern environ mainten function cilia depend intraflagellar transport ift use combin microfluid fluoresc microscopi studi respons phasmid chemosensori neuron live caenorhabd elegan chemic stimuli find chemic stimul result unexpect chang ift ciliari structur notabl stimul hyperosmot solut chemic repel result differ respons ift ciliari structur cargo distribut also neuron activ respons chemic repel result habitu neuron activ suggest ift play role regul chemosensori respons find show cilia abl sens respond differ extern cue distinct way highlight flexibl natur cilia sens hub | D017173;D029742 | T116;T204 |
36,223,753 | steroid hormon catabolit activ pyrin inflammasom non canon mechan pyrin inflammasom act guard rhoa gtpase central immun defens rhoa manipul pathogen pyrin activ proceed two step yet second step still poor understood use cell constitut activ pyrin step chemic screen identifi etiocholanolon pregnanolon two catabolit testosteron progesteron act low concentr specif step activ high concentr metabolit fulli rapid activ pyrin human specif b domain depend manner without inhibit rhoa mutat mefv encod pyrin caus two distinct autoinflammatori diseas pyrin associ autoinflamm neutrophil dermatosi paand famili mediterranean fever fmf monocyt paand patient lower extent fmf patient display increas respons metabolit studi identifi unconvent pyrin activ mechan indic endogen steroid catabolit drive autoinflamm pyrin inflammasom explain steroid fever describ late upon steroid inject human | D010505;D058847;D000071198 | T047;T123;T116 |
36,223,752 | mechan g checkpoint control epitheli cell divis e cadherin mediat regul wee cdk epitheli cell divis coordin cell loss preserv epitheli integr howev epithelia adapt rate cell divis chang cell number instanc homeostat turnov wound well understood show epitheli cell sens local cell densiti mechanosensit e cadherin adhes control gm cell cycl progress local cell densiti increas tensil forc e cadherin adhes reduc prompt accumul g checkpoint kinas wee downstream inhibitori phosphoryl cdk consequ dens epithelia contain pool cell temporarili halt g phase cell readili trigger divid follow epitheli wound due consequ increas intercellular forc result degrad wee data collect show epitheli cell divis control mechan g checkpoint regul cell densiti depend intercellular forc sens transduc e cadherin adhes | D015820;D004847 | T025;T123;T116 |
36,223,751 | tempo mode gene regulatori program bacteri infect innat immun recognit bacteri pathogen key determin ensu system respons host pathogen heterogen earli interact impact cours infect gain insight host respons heterogen investig macrophag inflammatori dynam use primari human macrophag infect group b streptococcus transcriptom analysi reveal discret cellular state within respond macrophag one consist four sub state reflect inflammatori activ infect six addit bacteri speci staphylococcus aureus listeria monocytogen enterococcus faecali yersinia pseudotuberculosi shigella flexneri salmonella enterica recapitul state though differ frequenc show modul durat infect presenc toxin impact inflammatori trajectori dynam provid evid trajectori infect macrophag vivo model staphylococcus aureus infect cell state analysi defin framework understand inflammatori activ dynam respons bacteri infect | D001424;D008089 | T007;T047 |
36,223,750 | fungal gpi anchor protein gene function virul antivir factor show gene cpgap encod glycosylphosphatidylinositol anchor protein gpi ap chestnut blight fungus cryphonectria parasitica differenti express cryphonectria hypovirus chv infect function analysi use cpgap null mutant result observ chang cultur morpholog hypersensit ros analysi protein product cpgap gene cpgap confirm motif antioxid properti virul cpgap null mutant signific decreas phytotox activ seen peptid cpgap chv transfer cpgap null mutant result sever retard coloni growth virus titer signific increas mycelia chv infect cpgap null mutant result indic cpgap function protect barrier plant defens also act virul factor moreov studi demonstr cpgap gene host toler antivir factor help maintain fungal growth suppress viral titer chv infect | D012328 | T005 |
36,223,749 | calcium permeabl ampa receptor aii amacrin cell mediat sustain signal pathway primat retina midget parasol ganglion cell gcs repres major output channel primat eye brain type midget parasol gcs exhibit higher background spike rate thus respond linear contrast chang type counterpart show calcium permeabl ampa receptor cp ampar antagonist block background spike sustain light evok fire type gcs preserv transient light respons effect select gcs occlud gap junction blocker suggest involv aii amacrin cell aii ac direct record aii ac cobalt uptak experi analys transcriptom data confirm cp ampar express primat aii ac overal data demonstr background light level cp ampar rod bipolar aii ac synaps drive sustain signal type gcs thus contribut linear contrast signal primat versus pathway | D025042;D018091 | T025;T116;T192 |
36,223,748 | midbrain dopamin neuron signal phasic ramp reward predict error goal direct navig goal direct navig requir learn accur estim locat select optim action locat midbrain dopamin neuron involv reward valu learn link reward locat learn therefor ideal place provid teach signal goal direct navig imag dopamin neural activ mice learn activ navig close loop virtual realiti corridor obtain reward observ phasic pre reward ramp dopamin activ modul learn stage task engag q learn model incorpor posit infer recapitul result display predict error resembl phasic ramp dopamin neural activ model predict ramp follow improv task perform confirm experiment data indic dopamin ramp may teach effect result suggest midbrain dopamin neuron encod phasic ramp reward predict error signal improv goal direct navig | D004298;D059290 | T121;T025;T109;T123 |
36,223,747 | cancer specif helper share neo epitop uncov express mhc class ii master regul ciita report approach identifi tumor specif cd cell neo epitop mous human cancer cell analysi major histocompat complex mhc class ii elut natur peptid mhc class ii present peptid sequenc identifi introduc mhc class ii transactiv ciita tumor cell origin mhc class ii negat ciita express facilit cell surfac express mhc class ii molecul appropri peptid load machineri peptid elut purifi mhc class ii molecul subsequ mass spectrometri reveal oncovir neo epitop well share epitop immunolog relev epitop shown natur present dendrit cell immunogen synthet peptid vaccin induc function cd cell respons help tumor control vivo thus ciita transfect approach aid identifi relev helper epitop present mhc class ii allel would otherwis difficult predict reveal import target cancer immunotherapi | D019496;D009369;D009687;D015534 | T116;T121;T191;T123;T129 |
36,223,746 | inhibit hck myeloid cell restrict pancreat tumor growth metastasi pancreat ductal adenocarcinoma pdac aggress diseas low year surviv rate associ poor respons therapi elev express myeloid specif hematopoiet cell kinas hck observ pdac correl reduc patient surviv determin whether aberr hck signal myeloid cell involv pdac growth metastasi establish orthotop intrasplen pdac tumor wild type hck knockout mice genet ablat hck impair pdac growth metastasi induc immun stimulatori endotyp myeloid cell turn reduc desmoplast microenviron enhanc cytotox effector cell infiltr consequ genet ablat therapeut inhibit hck minim metastat spread enhanc efficaci chemotherapi overcam resist anti pd anti ctla stimulatori anti cd immunotherapi result provid strong rational hck develop therapeut target improv respons pdac chemo immunotherapi | D021441;D010190;D051572 | T191;T126;T116 |
36,223,745 | unusu mode baselin translat adjust cellular protein synthesi capac metabol need domain life mechan exist adjust translat capac nutrient restrict growth constraint mammalian target rapamycin mtor regul synthesi ribosom protein translat factor mammalian cell via phosphoryl la relat protein larp present model starvat induc translat silenc larp target mrnas carri termin oligopyrimidin top motif shift subpolysom ribonucleoprotein particl howev mrnas would protect degrad rapid made avail restor translat capac need remain enigmat address employ gradient profil sequenc grad seq monosom footprint challeng model find top mrnas instead translate silenc starvat undergo low baselin translat reduc initi rate mode regul ensur stabl top mrna popul starvat allow fast revers translat repress | D014176;D058570 | T044;T123;T116 |
36,223,744 | matern gut microbiota mediat intergener effect high fat diet descend social behavior dysbiosi matern gut microbiom pregnanc associ advers neurodevelopment outcom previous show matern high fat diet mhfd mice induc gut dysbiosi social dysfunct under synapt plastic deficit male offspr f reason hfd mediat chang matern gut microbiota drive offspr social deficit mhfd induc dysbiosi f femal mhfd offspr would likewis impair f social behavior metataxonom sequenc reveal reduc microbi rich among femal f mhfd offspr despit recoveri microbi rich among mhfd descend f mice display social dysfunct post wean limosilactobacillus reuteri treatment increas abund short chain fatti acid produc taxa rescu mhfd descend f social deficit l reuteri exert sexual dimorph impact gut microbiota configur increas discrimin taxa femal cohort collect result show multigener impact hfd induc dysbiosi matern lineag highlight potenti matern microbiom target intervent neurodevelopment disord | D059305;D000069196 | T007;T061;T001 |
36,223,743 | connectom analysi thalamus driven disinhibit cortic layer sensori signal transmit via thalamus primarili layer l primari sensori cortic inform averag neuron connect l avail detail higher order circuit structur known use three dimension electron microscopi connectom analysi thalamus driven inhibitori network l find thalam input drive subset interneuron high specif turn target excitatori neuron subtyp specif interneuron creat direct disinhibitori network direct driven thalam input neuron activ record show strong synchron sensori activ yield fold stronger activ star pyramid cell spini stellat line differenti window opportun activ excitatori neuron thalamus driven disinhibitori circuit model identifi high degre special microcircuitri l primari sensori cortex | D063132 | T017;T091 |
36,223,742 | altern somat germlin gene regulatori strategi starvat induc development arrest nutrient avail govern growth quiescenc mani anim arrest develop starv use c elegan l arrest model show gene express chang deep starvat surpris relat express germlin enrich gene increas day condit degrad larg subunit rna polymeras ii use auxin induc degron system analyz absolut express level find somat transcript requir surviv germlin maintain transcript quiescenc thousand gene continu transcrib soma though absolut abund declin relat express germlin transcript increas given extrem transcript stabil aberr activ transcript starv germ cell compromis reproduct demonstr import physiolog function transcript quiescenc work reveal altern somat germlin gene regulatori strategi starvat soma maintain robust transcript respons support surviv germlin maintain transcript quiescenc support futur reproduct success | D029742;D013217 | T116;T033 |
36,223,741 | mda ldl vaccin induc athero protect germin center deriv antibodi respons atherosclerosi chronic inflammatori diseas arteri lead thrombosi infarct stroke lead caus mortal worldwid immun pro atherogen mice malondialdehyd modifi low densiti lipoprotein mda ldl neo antigen athero protect howev immun respons mda ldl mechan respons athero protect complet understood find immun mice mda ldl elicit memori b cell plasma cell switch anti mda ldl antibodi well clonal expans affin matur indic mda ldl trigger bona fide germin center antibodi respons prdm flfl aicda cre ki ldlr pro atherogen chimera lack germin center deriv plasma cell show acceler atherosclerosi final show mda ldl immun athero protect mice lack germin center deriv plasma cell find give support develop mda ldl base vaccin prevent treatment atherosclerosi | D050197;D014612 | T047;T046;T116;T121;T129 |
36,223,740 | parp inhibit reprogram macrophag toward anti tumor phenotyp poli adp ribosyl inhibitor parpi toxic cancer cell homolog recombin hr defici hr profici cell tumor microenviron tme includ tumor associ macrophag tam tam promot inhibit tumor growth set examin effect parp inhibit tam brca relat breast cancer bc parpi olaparib caus reprogram tam toward higher cytotox phagocytosi parpi relat surg nad increas glycolysi blunt oxid phosphoryl induc revers mitochondri electron transport ret increas reactiv oxygen speci ros transcript reprogram reprogram occur absenc presenc parp parp partial recapitul addit nad deriv methyl nicotinamid mna vivo ex vivo effect olaparib tam contribut anti tumor efficaci parpi vivo blockad nt eat signal cd antibodi combin olaparib improv outcom brca relat bc model | D051928;D000067856 | T121;T116;T129 |
36,223,739 | vimentin inhibit type interferon product disrupt tbk ikk irf axi cytoskeleton protein report involv host antivir immun respons howev cytoskeleton protein regul host antivir immun respons fulli understood report cytoskelet protein vimentin negat regul type interferon ifn product upon viral infect ectop express vimentin suppress rna dna virus induc ifn product wherea knockout vimentin express enhanc ifn product viral infect increas vimentin express ultim inhibit ifn product mechanist upregul vimentin interact tbk ikk disrupt interact tbk irf ikk irf result inhibit irf phosphoryl nuclear transloc furthermor generat vimentin knockout mice confirm defici vimentin gene mice suppress encephalomyocard virus replic vivo find demonstr vimentin play import role regul ifn product reveal antivir function cytoskelet protein vimentin | D051550;D007370 | T116;T121;T126;T123;T129 |
36,223,738 | estrogen receptor activ inhibit coliti promot nlrp mediat autophagi estrogen receptor er nod like receptor famili pyrin domain contain nlrp high express intestin tissu loss er nlrp exacerb coliti mous model howev under mechan incomplet understood report er direct activ nlrp gene express via bind estrogen respons element nlrp gene promot er also physic interact nlrp nucleotid bind domain promot nlrp inflammasom assembl er nlrp axi interact multipl autophagi relat protein includ ulk becn atgl lcb p affect autophagosom biogenesi autophag flux final nlrp mediat autophagi suppress inflammatori respons promot k link polyubiquitin asc casp p il tnf prohibitin thus er nlrp direct anti inflammatori respons promot autophagi work uncov er nlrp autophagi pathway regulatori mechan maintain intestin epitheli cell homeostasi facilit tissu repair coliti | D003092;D047629;D011956 | T047;T116;T192 |
36,223,737 | long term potenti reconstitut artifici tarppsd complex critic role ampa receptor ampar traffick long term potenti ltp excitatori synapt transmiss well establish under molecular mechan still uncertain recent research suggest psd captur ampar via interact ampar auxiliari subunit transmembran ampar regulatori protein tarp determin interact core minim compon ampar traffick ltp mechan engin artifici bind partner individu biochem function dead express togeth rescu bind basal synapt transmiss ltp find establish tarppsd complex essenti interact under ampar traffick ltp | D017774;D018091 | T042;T116;T192 |
36,223,728 | predict long term effect rtms autism spectrum disord use tempor variabl analysi scalp eeg object repetit transcrani magnet stimul rtms emerg use therapi autism spectrum disord asd clinic wherea mechan action rtms asd fulli understood biomark avail reliabl predict follow rtms efficaci clinic practic approach current work tempor variabl investig rest state electroencephalogram asd patient nonlinear complex relat time vari network accord evalu fuzzi entropi main result result show hyper variabl rest state network asd patient three week rtms treatment allevi hyper fluctuat occur frontal pariet frontal occipit connect contribut amelior asd symptom addit chang variabl network properti close correl clinic score serv potenti predictor reliabl track long term rtms efficaci asd signific find consist demonstr tempor variabl time vari network asd patient could modul rtms relat variabl properti also help predict follow rtms efficaci provid potenti formul individu treatment strategi asd chictr | D050781;D000067877 | T061;T062;T048 |
36,223,727 | synthesi character applic gold nanoparticl develop plasmon optic fiber base sensor gold nanoparticl au nps readili use nanoparticl find applic field like biosensor drug deliveri optic bioimag mani state art system use detect recent year fiber optic sensor seen util au nps along nanoparticl implement sensor sens various biomolecul like cholesterol glucos uric acid cancer cell creatinin bacteria also detect fiber optic sensor given signific au nps fiber optic sensor current work review synthesi common method use character applic au nps import discuss analys work report literatur understand trend gap develop plasmon optic fiber sensor | D053768;D015374 | T059;T075;T073 |
36,223,726 | spatial map cell receptor transcriptom reveal distinct immun nich interact adapt immun respons cell mediat antigen specif immun respons diseas specif divers clonotyp cell receptor tcrs determin spatial distribut cell clonotyp tissu essenti understand cell behavior spatial sequenc method remain unabl profil tcr repertoir develop slide tcr seq resolut method sequenc whole transcriptom tcrs within intact tissu confirm abil slide tcr seq map characterist locat cell receptor mous spleen human lymphoid germin center identifi spatial distinct tcr repertoir profil cell renal cell carcinoma melanoma specimen reveal heterogen immun respons cell state infiltr differ intra inter clonal adjac tumor immun cell exhibit distinct gene express altogeth method yield insight spatial relationship clonal neighbor cell type gene express drive cell respons | D011948;D059467 | T116;T192;T086;T081;T129 |
36,223,725 | cytokin drive prostat cancer lineag plastic lineag plastic critic mechan therapeut resist cancer recent issu scienc chan colleagu demonstr earli lineag plastic prostat cancer driven jak stat inflammatori cytokin signal | D016207;D011471 | T191;T116;T129 |
36,223,724 | explor vast microbi epitop space spectrum origin commens bacteri hla epitop well understood issu immun pedersen et al provid systemat analysi commens bacteri hla ii epitop demonstr plastic correspond cd cell respons | D015496;D018984 | T025;T129 |
36,223,723 | hairi situat ilc overal contribut type immun cutan barrier integr poor understood issu immun ricardo gonzalez et al demonstr mechan type cytokin group innat lymphoid cell ilc regul demodex mite colon maintain skin homeostasi | D007113;D008214 | T025;T032 |
36,223,722 | elo world earli life origin b cell immun cell generat earli life play pivot role immun homeostasi adulthood vergani et al identifi popul earli life origin iga b cell maintain throughout life achiev homeostasi adult gut | D001402;D000069497 | T025;T070 |
36,223,721 | take villag skew lymph node unconvent cell utc play import role protect barrier tissu issu immun ataid colleagu show addit function cell popul downstream lymph node skew cytokin profil process allow tissu adjust function drain lymph node imprint utc cytokin product subsequ influenc immun respons trigger | D008198;D013601 | T023;T025 |
36,223,717 | util dental care incid dementia longitudin studi older japanes cohort relationship periodont diseas dementia report import visit dentist maintain healthi periodont tissu studi report associ dental visit risk dementia studi examin relationship use dental care among older peopl incid dementia base health insur claim data | D010510;D003704 | T047;T048 |
36,223,715 | metabol profil ultra process food consumpt role obes risk british children higher consumpt ultra process food upf associ childhood obes under mechan remain unclear investig plasma nuclear magnet reson metabol profil higher upf consumpt role obes risk british alspac cohort | D005973;D063766 | T047;T116;T121;T123;T033 |
36,223,714 | associ circul docosahexaeno acid lung cancer mendelian random studi lung cancer malign tumor high incid vital identifi modifi avoid risk factor primari prevent signific lower risk cancer prevent exposur hazard alter riski behavior observ studi suggest increas docosahexaeno acid dha consumpt reduc lung cancer risk howev interpret observ find difficult due residu confound revers causal evalu link dha lung cancer undertaken analysi examin causal associ dha risk lung cancer use two sampl mendelian random mr framework | D008175;D000077192 | T191 |
36,223,713 | matern stress postpartum period associ alter human milk fatti acid composit matern stress postpartum period affect mother also newborn child increas risk wide rang disord later life mechan under transmiss matern stress child remain elus human milk hm potenti candid import sourc fatti acid fa crucial child neuro develop studi aim investig whether matern psycholog biolog stress influenc hm fa composit first month postpartum | D008895;D005227 | T109;T123;T031;T168 |
36,223,712 | ca mg ratio medium chain fatti acid gut microbiom ketogen medium chain fatti acid mcfas profound health benefit common found dairi product palm kernel oil coconut oil hypothes magnesium mg supplement lead enhanc gut microbi product mcfas turn increas circul mcfas level | D000069196 | T007;T001 |
36,223,711 | impact healthcar set post covid mood disord singl centr perspect southern itali respiratori intens care unit post covid syndrom includ sever clinic ident physic mental alter last sever month acut phase covid diseas howev date data concern relationship healthcar set covid diseas post covid mood disord lack | D000086382 | T047;T067 |
36,223,710 | virtual real world implement deep learn base imag denois model project domain digit tomosynthesi cone beam comput tomographi data reduc radiat dose caus sever imag nois artifact degrad imag qualiti also affect accuraci diagnosi find solut compris concaten convolut encod decod cce structur sensit loss ssl via transfer learn tl denois project domain low dose comput tomographi ldct radiographi tomosynthesi simul real world practic result show mani figur merit fom increas project time ct imag time psnr structur similar index measur ssim cce model effect denois keep shape structur henc develop denois model serv promis tool implement next generat x ray radiographi tomosynthesi ldct system | D000077321 | T066 |
36,223,701 | assembl inner filter effect reduc sns quantum dot base hollow polymer spheric nanoshel ratio electrochemiluminesc bioassay sns quantum dot qds excel electrochemiluminesc ecl lumin exhibit good applic prospect ecl field difficulti effect immobil electrod inner filter effect caus compact packag make construct sns qds base ecl system challeng work develop hollow polymer spheric nanoshel hpsns load sns qds sio nanoparticl nps serv carrier multilay assembl polyethyleneimin pei sns qds polyacryl acid paa sio nps etch produc sns qds base hpsns sns hpsns achiev high load sns qds effect reduc inner filter effect reveal signific improv cathod ecl perform sns hpsns coupl anod lumin ir nanorod nrs construct ratiometr ecl biosensor detect cardiac troponin ctni tripropylamin tpra persulf anod cathod co reactant respect norepinephrin ne gold nanoparticl aunp innov develop dual quencher ir nrs secondari antibodi complex contain sns hpsns ne aunp special construct assembl biosensor modifi ir nrs conveni realiz differ chang two signal thus achiev sensit detect ctni detect limit pgml hpsns provid effect strategi high load qds reduc inner filter effect integr two lumin sns hpsns ir nrs dual quencher creat promis ecl ratio platform accur detect various biomark | D045663;D015374;D057145;D053768 | T059;T075;T073 |
36,223,698 | analyt model calcul voxel valu lu object lu one employ isotop target radionuclid therapi theranost intern dosimetri procedur great import voxel valu vsvs approach wide use purpos vsvs avail limit number voxel dimens aim work develop analyt model calcul lu vsvs cubic voxel geometri practic interest approach mont carlo mc simul implement toolkit gamo evalu vsvs voxel geometri soft tissu sourc lu homogen distribut central voxel nine geometr setup contain cubic voxel side l rang mm mm step mm consid l vsvs comput function normal radius r n rl r distanc center sourc voxel fit parametr function depend paramet function l fit appropri function order implement model deduc lu vsvs l within aforement rang main result mc deriv vsvs satisfactorili compar literatur data valid vsvs comput analyt model agre mc one within r n within r n signific propos model enabl easi fast calcul simpl spreadsheet lu vsvs cubic voxel geometri practic interest avoid necess implement ad hoc mc simul estim vsvs specif voxel dimens avail literatur data | D011874 | T059;T074;T073 |
36,223,697 | aurapten citrus peel deriv natur product prevent myocardi infarct induc heart failur activ ppar rat aurapten deriv peel citrus hassaku possess anti tumor anti inflammatori neuroprotect activ thus could valuabl pharmacolog altern treat diseas howev therapeut valu aurapten heart failur hf unknown | D001688;D002957;D006333;D009203 | T047;T046;T002;T121;T123;T168 |
36,223,694 | efficaci machin learn assist dental age assess local popul although dental age assess common appli forens matur evalu long stand dilemma popul differ limit applic | D000366;D014070 | T023;T060 |
36,223,688 | evolut transient luminesc assembl regul trace water organ solvent trace water organ solvent play crucial role construct supramolecular assembl gain enough attent recent year herein demonstr residu water organ solvent play decis role regul evolut assembl structur function ad mg clo multi compon organ solut contain terpyridin base ligand tpi monodent imidazol base ligand system underw unexpect kinet evolut metallo supramolecular polym msp form first coordin tpi mg subsequ decompos due interfer result transient msp system investig reveal occur residu water solvent cooper coordin mg allow captur mg msp led depolymer howev owe slow reaction trace water mg format msp still occur first therefor water regul thermodynam kinet system key factor construct transient msp fine tune water content assembl motif regul assembl evolut pathway tune msp lifetim made luminesc color system undergo intrigu transit process time | D014867;D007093 | T121;T109;T197 |
36,223,687 | understand zigzag multi echo phase signal numer simul understand multi echo phase zigzag signal instrument assur qualiti mri phase data acquisit ensu phase explor exploit paper provid theoret comput mechan understand zigzag multi echo phase format observ numer multi echo gradient recal gre simul clinic complex valu brain mri imag base intravoxel dephas mechan calcul train multi gre complex valu voxel signal simul field gradient revers perturb either gradient strength g g gradient durat well simultan bi variabl gradient perturb g theoret experi observ zigzag line one shot multi echo phase signal voxel respect linear stepwis field gradient variat g n n n denot echo index howev multi echo magnitud signal invari field gradient revers ie multi echo magnitud zigzag support simul analyz clinic one shot multi echo weight mri phase imag found similar multi echo phase zigzag way provid theoret comput understand multi echo phase zigzag artifact specif eddi current effect one shot multi gre signal practic | D016477;D008279 | T059;T068;T060;T170 |
36,223,684 | automat identif septal flash phenomenon patient complet left bundl branch block complet left bundl branch block clbbb electr conduct disord associ cardiac diseas septal flash sf involv septal leftward contract earli systol follow lengthen motion toward right ventricl affect sever patient clbbb reveal clbbb patient sf may risk cardiac function reduct poor prognosi therefor accur identif sf may play vital role counsel patient prognosi general septal flash identifi echocardiographi use visual eyebal howev convent method subject depend oper experi studi build linear attent cascad net lacnet capabl process echocardiographi identifi sf automat propos method consist cascad cnn base encod lstm base decod extract spatial tempor featur simultan spatial transform network stn modul employ avoid imag inconsist linear attent layer implement reduc data complex moreov left ventricl lv area time curv calcul segment result consid new independ diseas predictor sf phenomenon lead transient left ventricl area enlarg therefor ad left ventricl area time curv lacnet enrich input data divers result show possibl use echocardiographi diagnos clbbb sf automat | D002037;D004452 | T047;T046;T060 |
36,223,683 | gaze assist automat caption fetal ultrasound video use three way multi modal deep neural network work present novel gaze assist natur languag process nlp base video caption model describ routin second trimest fetal ultrasound scan video vocabulari spoken sonographi primari novelti multi modal approach learn video caption model built use combin ultrasound video track gaze textual transcript speech record textual caption describ spatio tempor scan video content learnt sonograph speech record generat caption assist sonograph gaze track inform reflect visual attent perform live imag interpret frozen imag evalu effect ad withhold differ form gaze video model compar spatio tempor deep network train use three multi modal configur name gaze less neural network text video input neural network addit use real sonograph gaze form attent map neural network use automat predict gaze form salienc map instead assess algorithm perform establish general text base metric bleu roug l f score domain specif metric ar metric consid rich effici generat caption respect scan video result show propos gaze assist model generat richer divers caption clinic fetal ultrasound scan video without gaze expens perceiv sentenc structur result also show generat caption similar sonograph speech term discuss visual content scan action perform | D016571;D000465 | T170 |
36,223,682 | word larg scale dataset benchmark clinic applic studi abdomin organ segment ct imag whole abdomin organ segment import diagnos abdomen lesion radiotherapi follow howev oncologist delin abdomin organ volum time consum expens deep learn base medic imag segment shown potenti reduc manual delin effort still requir larg scale fine annot dataset train lack larg scale dataset cover whole abdomen region accur detail annot whole abdomin organ segment work establish new larg scale whole abdomin organ dataset word algorithm research clinic applic develop dataset contain abdomin ct volum slice volum organ fine pixel level annot scribbl base spars annot may largest dataset whole abdomin organ annot sever state art segment method evalu dataset also invit three experienc oncologist revis model predict measur gap deep learn method oncologist afterward investig infer effici learn word high resolut imag requir larg gpu memori long infer time test stage evalu scribbl base annot effici learn dataset pixel wise manual annot time consum expens work provid new benchmark abdomin multi organ segment task experi serv baselin futur research clinic applic develop | D014057;D019985 | T060;T081 |
36,223,677 | hydrat electron base photochem process water treatment hydrat electron e aq base photochem process emerg promis technolog contamin remov water due mild oper condit review aim provid comprehens date summari e aq base photochem process decomposit various oxid contamin specif characterist differ photo reduct system first elabor includ environ requir generat suffici e aq advantag disadvantag system comparison degrad effici contamin induc e aq addit identif method e aq eg laser flash photolysi scaveng studi chemic probe electron spin reson techniqu summar influenc oper condit eg solut ph dissolv oxygen sourc chemic concentr uv type perform contamin also discuss consid complex contamin water particular attent paid influenc water matrix eg coexist anion alkalin humic acid moreov degrad regular various contamin eg perfluorin compound disinfect product nitrat e aq summar final put forward sever research prospect decomposit contamin e aq base photochem process promot practic applic water treatment | D014874;D018508 | T057;T131;T052 |
36,223,676 | childhood vs juvenil absenc epilepsi make diagnosi tri differenti childhood absenc epilepsi cae juvenil absenc epilepsi jae base clinic characterist plan identifi cutoff point age onset seizur cae jae abl reliabl predict presenc general tonic clonic seizur gtcs import implic treatment strategi outcom predict | D004832;D004829 | T047 |
36,223,675 | brivaracetam add treatment pediatr patient sever drug resist epilepsi italian real world evid report efficaci toler brivaracetam brv add therapi pediatr patient sever drug resist epilepsi prognost factor clinic outcom also analyz | D000069279;D004829;D004827 | T047;T033 |
36,223,666 | finerenon diabet kidney diseas systemat review critic apprais finerenon novel non steroid mineralocorticoid antagonist mra recent approv treatment chronic kidney diseas ckd peopl type diabet td aim conduct systemat review finerenon know efficaci safeti finerenon ckd without td | D003928;D006947;D003924;D006333;D051436 | T047;T046;T033 |
36,223,665 | nanofluid devic separ biomolecul last year microchip electrophoresi applic expand due benefit offer nanochip electrophoresi hand view evolv area electrophoresi offer uniqu advantag associ microchip electrophoresi advantag aris uniqu phenomena occur nanomet domain readili appar microscal domain due scale depend effect scale depend effect associ nanochip electrophoresi includ high surfac area volum ratio electr doubl layer overlap generat parabol flow even electrokinet pump concentr polar transvers electromigr surfac charg domin flow surfac rough nanochip electrophoresi devic consist channel dimens rang nm includ classic nm extend nm nm nanoscal devic review highlight scale depend phenomena associ nanochip electrophoresi util phenomena provid uniqu biomolecular separ possibl microchip electrophoresi also review rang materi use nanoscal separ implic materi choic top fabric oper devic also provid applic exampl nanochip electrophoresi biomolecul separ emphasi nano electrophoresi nep nano electrochromatographi nec | D046209 | T059 |
36,223,664 | data scienc driven analysi substrat permiss diketopiperazin revers prenyltransferas notf applic protein engin cascad biocatalyt synthesi eurotiumin prenyltransf earli stage carbon hydrogen bond c h function preval biosynthesi divers array biolog activ bacteri fungal plant metazoan diketopiperazin dkp alkaloid toward develop unifi strategi biocatalyt construct prenyl dkp indol alkaloid sought identifi character substrat permiss c revers prenyltransferas pt first tailor event within biosynthesi cytotox notoamid metabolit pt notf catalyz c revers prenyltransf brevianamid f solv crystal structur notf complex nativ substrat prenyl donor mimic dimethylallyl thiolodiphosph dmspp reveal larg solvent expos activ site intim notf may possess signific broad substrat scope assess substrat select notf synthes panel steric electron differenti tryptophanyl dkps major select prenyl notf synthet use convers quantit represent substrat librari develop descript statist model provid insight molecular origin notf substrat promiscu approach enabl identif key substrat descriptor electrophil size flexibl govern rate notf catalyz prenyltransf develop induc fit dock ifd guid engin strategi improv turnov largest substrat demonstr util notf tandem oxid cyclize use flavin monooxygenas bvnb one pot vitro biocatalyt cascad enabl first chemoenzymat synthesi marin fungal natur product eurotiumin three step overal yield | D004122;D001688 | T121;T126;T116;T123 |
36,223,657 | glutaminas blockad allevi nonalcohol steatohepat via promot prolin metabol nonalcohol steatohepat nash emerg major caus end stage liver diseas nowaday pharmacolog therapi approv urgent need develop new therapeut target glutaminas gls knockdown put forward allevi nash mechan still unclear herein explor exact relationship glutamin metabol nash develop establish nash mice model identifi jhu proven gls inhibitor could effici allevi nash remark jhu could decreas lipid content liver enhanc fatti acid oxid capac consider transcriptom analysi reveal jhu administr could influenc prolin metabol found efficaci jhu lipid metabol reli prolin prolin metabol block gls inhibitor longer work data suggest inhibit glutamin hydrolysi could promot fatti acid oxid regul prolin metabol close associ nash develop could consid new possibl therapeut target nash therapi | D065626 | T047 |
36,223,650 | isegmsi interact strategi improv spatial segment mass spectrometri imag data spatial segment critic procedur mass spectrometri imag msi base biochem analysi howev common use unsupervis msi segment method may lead inappropri segment result msi data character high dimension low signal nois ratio process improv incorpor precis prior knowledg hard obtain case studi show incorpor partial coars prior knowledg differ sourc refer imag biolog knowledg may also help improv msi segment result propos novel interact segment strategi msi data call isegmsi incorpor prior inform form scribbl regular unsupervis model fine tune segment result use two typic msi data set includ whole bodi mous fetus human thyroid cancer present result demonstr effect isegmsi strategi improv msi segment specif method use subdivid region sever subregion specifi user defin scribbl merg sever subregion singl region addit fine tune result high toler imprecis scribbl result suggest propos isegmsi method may effect preprocess strategi facilit analysi msi data | D007091;D005333 | T018;T024;T066;T019 |
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