PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,223,643 | hyperval phosphorus v porphyrin meso methoxyphenyl substitu signific number posit methoxi group promot intramolecular charg transfer studi photophys redox properti function meso aryl unit seri hyperval phosphorus v porphyrin pp ome pf pmp ome pf pdmp ome pf ptmp ome pf ptmp ome pf phenyl p methoxyphenyl mp dimethoxyphenyl dmp trimethoxyphenyl tmp trimethoxyphenyl tmp unit respect synthes p caviti make porphyrin ring electron poor wherea methoxi group make meso phenyl ring electron rich presenc electron rich electron poor portion within porphyrin molecul promot intramolecular charg transfer ict also studi suggest ict depend number posit methoxi group ict promin methoxi substitut phosphorus v porphyrin pdmp ome pf ptmp ome pf almost ict found methoxi methoxi andor p methoxi phosphorus v porphyrin pp ome pf pmp ome pf ptmp ome pf transient absorpt studi indic ict take place picosecond time scale strike result come ptmp ome pf phenyl ring carri three methoxi unit like ptmp ome pf fail induc ict process electrochem studi time depend densiti function theori td dft calcul use support experiment result studi extens explor slight variat meso aryl substitut lead intric chang photophys redox properti phosphorus v porphyrin | D011166 | T109;T123 |
36,223,641 | prepar dienyl boron tandem ene yne metathesisdienyl isomer readi access dien build block synthesi polyen ene yne metathesi alkenyl boron termin alkyn report challeng metathes accomplish use grubb catalyst bear cyclic alkyl amino carben caac ligand wherea n heterocycl carben nhc deriv catalyst gave lower yield subsequ dienyl isomer via cobalt catalyz hydrogen atom transfer hat furnish substitut dienyl boron high ee ez ratio final result dienyl boron product success use suzuki miyaura cross coupl reaction diel alder cycloaddit | D011090;D000480 | T109 |
36,223,639 | mildr stahlman centenarian pioneer modern scientif neonat intens care neonatolog pioneer mildr milli stahlman celebr th birthday juli distinguish career vanderbilt univers medic center nashvill tn review commemor mileston stahlman arguabl first establish modern neonat intens care unit success util negat pressur ventil umbil arteri venous cathet monitor blood gass ph level receiv earli invalu train newborn physiolog karolinska institut stockholm sweden john lind petter karlberg vanderbilt elliot v newman stahlman also consult luminari geoffrey daw donald barron l stanley jame director vanderbilt nicu train fellow countri latter year career highlight collabor jeff whitsett recipi aap virginia apgar award ap john howland medal serv member institut medicin | D047928;D029424;D011014 | T050;T047;T046 |
36,223,637 | select oxid biomass molecul via zno nanoparticl modifi use charg mismatch dope co ion charg mismatch transit metal ion dopant metal oxid nanoparticl mo nps within engin complex engend signific number oxygen vacanc v surfac mo np construct elucid depth mechan tendenc co ion differ charg state co co dope zno nps atom structur chang correl photocatalyt effici ascertain increas zn bond distanc distinct affect co ion dope subsequ number v notic increas investig mechanist pathway photocatalyt oxid hydroxymethylfurfur hmf wide investig biomass deriv potenti use precursor synthesi sustain altern petrochem substanc identifi reaction product oxid step select oxid product obtain hmf presenc pristin zno nps co co ion dope zno nps evalu confirm co ion dope zno nps effici select oxid hmf good convers rate convert hmf furandicarboxyl acid fdca present studi demonstr feasibl improv product effici fdca altern energi materi use enhanc photocatalyt mo nps help charg mismatch mo metal ion dopant | D015034;D053768 | T121;T073;T197 |
36,223,633 | high oxid germacranolid elephantopus tomentosus configur revis previous report analogu high oxid germacranolid main found genus elephantopus contain characterist ten member molecular core high flexibl exhibit potenti cytotox properti howev configur assign ambigu previous report due spectroscop observ macrocycl system herein high oxid germacranolid includ new germacranolid isol elephantopus tomentosus structur character spectroscop data analysi combin x ray crystallographi ecd calcul possibl propos configur revis five previous report analogu cytotox activ two hepatocellular carcinoma cell line hepg hepb test compound generat ic valu furthermor observ cytotox activ determin mediat induc apoptosi hepg hepb cell via mitochondri dysfunct | D000972;D019659;D000970 | T121;T109;T002 |
36,223,632 | evalu ground glass opac ggo covid era autoantibodi help covid infecti diseas caus sever acut respiratori syndrom coronavirus sar cov outbreak worldwid present may includ unspecif mild symptom myalgia headach high fever dri cough sever dyspnea acut respiratori distress syndrom ard | D000086382;D017563 | T047;T067 |
36,223,631 | klebsiella pneumonia k produc pyogen liver abscess associ biliari communic hypervirul strain klebsiella pneumonia gain clinic epidemiolog interest capac caus sever life threaten infect | D001659;D007710;D046290 | T023;T047 |
36,223,630 | commens multidrug resist neisseria spp sepsi felin sepsi serious problem felin mortal rate rang neisseria spp consid commens microorgan oral caviti dog cat usual isol human wound result bite anim | D002371;D004283;D010493;D011014;D018805 | T050;T047;T046 |
36,223,629 | knowledg awar hepat b hepat c hiv among pregnant women pakistan hepat b hepat c human immunodefici virus hiv affect signific proport populac develop countri pregnant women depriv segment popul disproportion affect aim studi assess awar regard three blood born infect amongst pregnant pakistani women belong low socioeconom class | D015658;D006509;D006526;D011251 | T047 |
36,223,628 | preval pediculus humanus capiti associ risk factor among elementari school age girl paveh west iran head lice infest consid common dermatolog health problem worldwid studi aim determin pediculosi preval associ risk factor among school age girl enrol public elementari school citi pave kermanshah provinc west iran studi find provid evid base upon multifacet intervent pediculosi formul implement | D010373;D010374 | T047;T204 |
36,223,627 | evalu hiv viral load turnaround time moshi tanzania viral load measur import gold standard monitor anti retrovir treatment among peopl live human immunodefici virus optim use viral load result guid antiretrovir therapi depend time avail result clinic object current studi evalu turnaround time util viral load result clinic decis process | D019380;D015658 | T121;T047 |
36,223,626 | tuberculosishiv co infect northeastern brazil preval trend spatial distribut associ factor object analyz preval trend spatial distribut tb hiv co infect associ factor endem scenario tb northeastern brazil | D060085;D015658;D055985;D014376 | T047 |
36,223,625 | concomit viral bacteri pneumonia among patient icu mechan respiratori support use mechan ventil intens care unit icu often associ higher risk respiratori tract infect includ ventil associ pneumonia vap concomit bacteri viral infect report worsen patient clinic condit studi evalu rate concomit bacteri viral infect patient vap analyz clinic outcom | D007251;D018410;D053717;D012141 | T047 |
36,223,624 | mortal predictor day healthcar associ acinetobact baumanni bacteremia intens care unit mortal healthcar associ acinetobact baumannii bacteremia intens care unit icus aim determin risk factor day mortal patient sepsi due baumannii bacteremia icu follow | D040981;D016470 | T007;T047 |
36,223,623 | preval distribut pathogen gene campylobact jejuni isol poultri human sourc campylobact jejuni one common bacteri caus human gastroenter despit public health import virul factor mechan under c jejuni pathogenesi remain poor understood relationship gene sourc strain clear aim determin virul profil c jejuni isol poultri human case campylobacteriosi | D002167;D002169;D016123;D005759 | T007;T047 |
36,223,622 | occurr methicillin resist staphylococcus aureus pet owner rural urban communiti trinidad occurr methicillin resist staphylococcus aureus mrsa pet owner increas due misus abus antibiot studi compar preval mrsa staphylococcus aureus strain pet owner urban rural communiti trinidad | D002371;D004283;D055624;D013203 | T007;T047 |
36,223,621 | high preval methicillin resist staphylococcus aureus carriag among infant children hospit accra ghana infant risk staphylococcus aureus aureus colon infect aim studi investig aureus methicillin resist aureus mrsa colon among infant includ preval predictor colon antibiogram | D055624;D013203 | T007;T047 |
36,223,620 | use procalcitonin level predict infect reduc unnecessari antibiot usag febril children age month high risk featur includ bodi temperatur bt c inact appear white blood cell wbc cellsmm absolut band count abc cellsmm low sensit negat predict valu npv discrimin bacteri viral infect lead overus antibiot aim determin whether procalcitonin pct level ngml differenti bacteri viral infect | D000900;D001424;D000077740 | T047;T116;T195;T121;T123 |
36,223,619 | covid infect among dentist iraqi kurdistan region covid incid relat high among dentist iraq reflect high number case communiti therefor possibl epidemiolog featur covid infect investig among dentist iraqi kurdistan region | D000086382 | T047;T067 |
36,223,618 | role hospit environment surfac transmiss sever acut respiratori syndrom coronavirus sever acut respiratori syndrom coronavirus sar cov main transmit via respiratori secret cough sneez contact contamin surfac virus present fece mani bodi fluid studi aim screen hospit environ potenti sourc sar cov transmiss identifi hospit zone highest contamin level | D000086382;D003428;D004866;D006761 | T047;T093;T073;T067 |
36,223,617 | surviv critic ill patient covid pneumonia singl center experi aim studi determin surviv probabl critic ill patient covid infect need mechan ventil determin efficaci tocilizumab use | D000086382;D012131 | T047;T046;T067 |
36,223,616 | impact covid pandem treatment prognosi acut myocardi infarct xuzhou china treatment acut myocardi infarct ami covid pandem affect vari degre studi first explor impact covid treatment prognosi rural urban ami develop countri | D000086382;D009203;D000072657 | T047;T067 |
36,223,615 | side effect pfizer biontech vaccin health worker hospit southeast mexico goal studi evalu side effect applic pfizer biontech vaccin worker mexican hospit | D000086382;D000086663 | T047;T200;T067 |
36,223,614 | systemat review bayesian network meta analysi compar safeti assess favipiravir intervent hospit covid patient covid coronavirus base infecti ill first detect end wuhan china novel virus induc sever acut respiratori syndrom sar cov spread global result ongo pandem still lack evid direct comparison favipiravir therapi network meta analysi nma may incorpor direct indirect comparison pool comput depend strong assumpt premis studi provid evid base recommend safeti current use clinic pharmacolog treatment compar favipiravir covid patient | D000086382 | T047;T067 |
36,223,613 | practic percept healthcar worker toward infect control measur covid pandem cross section onlin survey nigeria studi investig practic percept health care worker hcws nigeria toward infect control practic covid pandem | D000086382 | T047;T067 |
36,223,612 | corticosteroid effect among hospitalis covid patient malaysia use steroid manag hospitalis coronavirus diseas covid patient caus sever acut respiratori syndrom coronavirus sar cov infect shown reduc need mechan ventil mortal date low dose dexamethason methylprednisolon corticosteroid effect reduc infect progress hospitalis patient howev unknown high dosag corticosteroid achiev better clinic outcom studi aim compar clinic outcom hospitalis covid patient given day low dose corticosteroid treatment iv mgkgday methylprednisolon load dose ld mgkg four time day qid patient given day high dose corticosteroid treatment iv mg dexamethason daili od mgkg prednisolon tablet od | D000086382 | T047;T067 |
36,223,611 | navig covid outbreak zambia covid global public health crisi wreak havoc near everi corner globe zambia except amid alreadi exist diseas burden hivaid malaria malnutrit cholera resili health care system yet test especi sinc lack estim workforc meanwhil govern alreadi establish measur contain spread covid includ reorient train health worker indefinit closur learn institut ban non essenti travel covid vaccin roll ground mileston achiev thus far fight pandem expect intensifi | D000086382 | T047;T067 |
36,223,610 | review current vitro covid diagnost method diagnosi covid consid signific step manag diseas caus major worldwid public health challeng time emerg decemb sinc establish sar cov spread rapid time detect posit case isol individu contact help contain viral transmiss paper review vitro technolog platform test diagnos covid patient molecular test rapid antigen test serolog test part review categori test discuss commerci test platform analyz system specimen collect protocol test methodolog moreov efficaci limit techniqu also discuss key structur compon virus present provid understand scientif principl behind test tool | D000086382 | T047;T067 |
36,223,604 | effect diglym au nanoclust format mechan h nmr bond recent diglym appli solvent synthesi luminesc gold thiolat nanoclust howev interact diglym gold nanoclust intrins mechan diglym assist nanoclust growth examin work use densiti function theori dft propos plausibl pathway diglym assist au thiolat synthesi reaction energi found negat everi step h nmr calcul appli character environ aris differ gold motif affect chemic shift proton diglym experi strong downfield shift extend transit state natur orbit chemic valenc et nocv theori also util examin interact diglym gold cluster well au sr nanoclust work demonstr diglym play import role synthet mechan yield gold nanoclust provid insight diglym nanoclust bind motif result nmr chemic shift | D011522;D006046 | T121;T196 |
36,223,596 | one pot cascad annul trigger synthesi n substitut norcryptotackiein alkaloid evalu antileishmani activ norcryptotackiein h indolo b quinolin indoloquinolin class alkaloid isol cryptolepi sanguinolenta tradit use antimalari therapi addit structur tune extend therapeut potenc indoloquinolin antileishmani drug lead synthesi n function norcryptotackiein suffer necess complex pre synthes start materi restrict scope function tedious process consequ straightforward synthet procedur access non natur n function h indolo b quinolin potent antileishmani activ high sought herein report two step one pot synthesi n function norcryptotackiein pd catalyz doubl annul reaction commerci avail amphipath amin iodobenzyl cyanid differ function bromobenzaldehyd report procedur allow broad flexibl substitut n posit access diversifi scaffold includ two natur product norcryptotackiein neocryptolepin interest show potent antileishmani activ caus disrupt cytoskelet structur apoptot mediat death parasit togeth work manifest shortest rout n substitut norcryptotackiein deriv antileishmani agent | D011804;D000470;D000981;D000962;D000970 | T121;T131;T109;T123 |
36,223,588 | differ cancer screen respons state medicaid expans race ethnic object estim whether state medicaid expans relationship breast cervic colorect cancer screen differ raceethn method analys conduct use behavior risk factor surveil system data adult age year household incom feder poverti guidelin fpg n tripl differ analys compar cancer screen medicaid expans versus nonexpans state versus expans among peopl incom versus elig cutoff fpg raceethn ethnic languag interact term test effect modif result associ medicaid expans cancer screen signific past year mammogram past year colorect screen effect modif analys show elev mammographi among non hispan asian women percentag point confid interv ci hispan women percentag point ci papanicolaou test among hispan women percentag point ci find limit english spanish speak respond robust insur status control conclus medicaid expans yield statist signific increas incom elig asian hispan women mammographi hispan women pap test relat non hispan white women neither languag profici insur status explain find j public health https doiorgajph | D008484;D009369 | T191;T064;T089 |
36,223,587 | nonfat violenc involv day away work follow california workplac violenc prevent health care safeti standard object examin impact california occup safeti health administr calosha workplac violenc wpv prevent health care safeti standard nonfat violent injuri among health care worker hcws method access estim count wpv survey occup injuri ill specif hcws use current popul survey estim hcws creat rate per conduct longitudin panel analysi compar interrupt time seri analysi examin chang incid rate associ california new standard result adopt safeti standard led addit report wpv injuri per hcws california addit injuri sensit analys suggest injuri chang period conclus appear calosha standard increas report wpv injuri among hcws first year adopt compar unit state mandat report wpv incid health care set may mean ensur complet understand public health problem j public health https doiorgajph | D064450 | T054 |
36,223,586 | make vaccin equit avail person pima counti arizona review pima counti arizona health depart effort achiev equit covid vaccin distribut counti social vulner index expedit vaccin distribut focus equit distribut implement multi point dispens approach use periurban rural strategi pima counti one highest vaccin distribut percentag among highest social vulner index quartil percentag point ahead larg counti arizona vaccin uptak j public health https doiorgajph | D000086382;D014612 | T047;T116;T121;T129;T067 |
36,223,583 | mobil health servic covid counsel test vaccin medic underserv popul mobil health unit improv access prevent health servic especi medic underserv popul howev littl publish experi mobil health unit use expand access covid vaccin concert local public health depart communiti member implement mobil covid health unit deploy predomin low incom racialethn minor communiti massachusett describ success challeng innov program expand access covid vaccin j public health https doiorgajph | D000086382;D008507 | T047;T093;T083;T098;T067;T080 |
36,223,582 | gender raceethn union direct care occup object goal studi measur union direct care workforc relationship union earn look close differ across raceethn gender method use data current popul survey first use logit analys predict probabl union among direct care worker across raceethn gender measur relationship union week earn result found male black direct care worker like union follow hispan direct care worker color union direct care worker earn wage higher nonunion worker union worker color earn lower reward union compar white direct care worker conclus union mechan improv job qualiti direct care work protect worker right union particip collect bargain equit may way stabil grow direct care workforc j public health https doiorgajph | D003098;D005006 | T098;T057;T102 |
36,223,577 | abort crimin public health crisi root white supremaci suprem court decis overturn roe v wade grow onslaught state law crimin abort part long histori maintain white supremaci reproduct control black social margin live public health continu recogn structur racism public health crisi advanc measur imper explic connect abort crimin white supremaci essay highlight antiabort polici uphold white supremaci offer concret strategi address abort crimin structur racism measur public health research practic j public health https doiorgajph | D000028;D000029 | T093;T046;T061;T081;T033 |
36,223,576 | workplac violenc adolesc uganda object describ preval risk factor workplac violenc among ugandan adolesc method analysi focus adolesc recruit primari school particip endlin survey trial age year follow age year analysi restrict engag past year paid work n estim preval past year workplac violenc use mix effect multivari logist regress explor associ characterist measur earli adolesc current life circumst work relat factor method analysi focus adolesc recruit primari school particip survey follow analysi restrict engag past year paid work n estim preval past year workplac violenc use mix effect multivari logist regress explor associ characterist measur earli adolesc current life circumst work relat factor result overal confid interv ci adolesc paid work experienc past year workplac violenc odd doubl among femal domest worker vs retailtrad worker adjust odd ratio aor ci experi measur earli adolesc includ eat less meal previous day experienc sever physic violenc male adolesc aor ci femal adolesc aor ci bulli poor mental health male adolesc aor ci femal adolesc aor ci associ increas odd workplac violenc current life circumst fewer household asset move function difficulti poorer mental health also associ workplac violenc conclus intervent need address high preval workplac violenc across sector femal domest worker particular vulner earli prevent violenc poor mental health may promis j public health https doiorgajph | D058445;D064450 | T054;T048 |
36,223,575 | digit inclus farmwork pandem north carolina farmwork health program internet connect project north carolina farmwork health program ncfhp implement emerg program respons north carolina migrant season farmwork urgent need internet access health inform famili connect telehealth servic covid isol quarantin articl describ ncfhp internet connect project implement evalu june decemb project place devic across state provid internet access farmwork peak farm season j public health https doiorgajph | D000086382;D014171 | T098;T047;T067 |
36,223,573 | covid vaccin uptak factor affect hesit among us nurs march june object character covid vaccin uptak hesit among us nurs method survey nurs nation cohort spring particip indic plan receiv unsur whether plan receiv vaccin consid vaccin hesit result among femal current former nurs plan vaccin adjust age raceethn occup variabl vaccin hesit associ lower educ live south work group care home health set experienc covid death report person household vulner covid less like hesit contract covid doubl risk vaccin hesit confid interv ci reason hesit common among nurs plan receiv vaccin religioneth belief vaccin ineffect lack concern covid unsur often cite concern regard side effect medic reason report covid conclus vaccin hesit unusu stem specif concern public health implic target messag outreach might reduc vaccin hesit j public health https doiorgajph | D000086382;D014612 | T047;T116;T121;T129;T067 |
36,223,572 | characterist associ previous covid diagnosi vaccin uptak intent vaccin among essenti worker us household puls survey object explor previous covid diagnosi covid vaccin status among us essenti worker group method analyz us census household puls survey may juli nation repres sampl adult age year older compar current employ essenti worker work outsid home work home use adjust preval ratio calcul proport vaccin intent vaccin stratifi essenti worker demograph group work volunt outsid home sinc januari result proport worker previous covid diagnosi highest among first respond work outsid home compar worker worker agricultur forestri fish hunt lowest vaccin rate compar worker without health insur much less like vaccin across worker group conclus studi underscor import improv surveil monitor covid infecti diseas among worker identifi implement tailor risk mitig strategi includ vaccin campaign workplac j public health https doiorgajph | D016915;D000086382;D007252;D053918;D022261;D018449 | T047;T116;T121;T109;T129;T067 |
36,223,569 | sar cov mitig strategi test case jail us southeast octob may object character sever acut respiratori syndrom coronavirus sar cov mitig strategi test case across counti jail southeastern unit state examin variabl jail characterist method administ time telephon survey personnel jail alabama georgia north carolina south carolina octob may result sar cov mitig strategi eg screen intak isol mask symptomat person common report jail measur mask regardless symptom screen releas less common vari jail state popul size overal jail report sar cov test past day jail test test median per incarcer person jail one third report case posit test although jail detect case jail case past day test posit conclus low test coverag variabl implement sar cov mitig strategi southeastern us jail first year covid pandem j public health https doiorgajph | D000086382;D000086402 | T047;T067;T005 |
36,223,568 | lifeguard train program drown death rate ecuador drown common caus death disabl worldwid report experi ecuador middl incom countri lifeguard train program implement reduc incid drown describ project ecuador abl expand one beach five year period detail intervent trigger creation self sustain nation program law propos guarante safe environ across ecuadorian coastal region j public health https doiorgajph | D004332 | T037 |
36,223,562 | quantit measur cooper h bond network cooper h bond interact featur supramolecular network involv alcohol famili phenol oligom hydroxyl group form intramolecular h bond use investig phenomenon chain intramolecular h bond character use nuclear magnet reson nmr spectroscopi solut x ray crystallographi solid state phenol oligom use make quantit measur effect intramolecular interact strength intermolecular h bond interact h bond donor end chain seri h bond acceptor intramolecular h bond interact chain increas strength singl intermolecular h bond termin phenol quinuclidin kj mol n octan solut although magnitud effect increas length h bond chain first intramolecular h bond much larger effect subsequ interact h bond cooper domin pairwis interact nearest neighbor longer rang effect neglig result use develop simpl model cooper h bond network use empir paramet quantifi sensit h bond properti function group polar valu measur system mean format first h bond increas polar next h bond donor chain cumul cooper effect longer h bond chain reach asymptot valu correspond maximum increas polar termin h bond donor | D010636;D000438 | T121;T109 |
36,223,561 | dynam respons chromosom bind protein complex meiotic prophas mous spermatocyt meiotic prophas mpi import event mammalian meiosi status chromosom bind protein cbps correspond complex function mpi yet well scrutin quantit proteom focus mpi relat cbps accomplish mous primari spermatocyt four differ subphas mpi collect chromosom enrich protein extract quantit identifi accord stringent criterion cbps mpi subphas quantifi look dynam pattern cbp abund respons mpi progress pattern broad divid two group high abund leptoten zygoten pachyten diploten furthermor cbps regard cbp complex strict filtrat complex perceiv mpi depend first time complex basic belong four function categori dynam abund chang follow mpi appear function dna replic decreas transcript synapsi activ zygoten pachyten diploten contrast tradit predict condensin activ weaken pachyten diploten profil protein complex thus offer convinc evid import cbp complex mpi | D013090;D049469 | T025;T043;T079 |
36,223,527 | fast predict lipophil organofluorin molecul deep learn deriv polar charact experiment test fast accur estim lipophil organofluorin molecul great demand acceler drug materi discoveri lipophil data set organofluorin molecul ofl data set contain sampl construct densiti function theori dft calcul experiment measur effici interpret model call pologp develop predict n octanolwat partit coeffici log p ow organofluorin molecul basi descriptor polar combin polar descriptor includ molecular polar index molecular polariz hydrogen bond hbs index consist number donor n hb acceptor n hb n hb f present pologp combin polar descriptor demonstr perform better dipol moment alon f contain molecul aid multilevel attent graph convolut neural network model fast generat polar descriptor organofluorin molecul could achiev dft accuraci base topolog molecular graph structur perform pologp valid synthes organofluorin molecul non fluorin molecul satisfactori accuraci highlight potenti usag pologp high throughput screen function molecul desir solubl various solvent media | D000077321 | T066 |
36,223,525 | alloster inhibit ptpb nonpolar terpenoid protein tyrosin phosphatas ptps promis drug target treat wide rang diseas diabet cancer neurolog disord conserv activ site complic design select therapeut studi examin alloster inhibit ptpb amorphadien ad terpenoid hydrocarbon unusu select inhibitor molecular dynam md simul carri studi suggest ad stabli sampl multipl neighbor site alloster influenti c terminus catalyt domain bind site requir disord helix stabil ptpb ad complex may contribut select ad ptpb tcptp intrigu bind mode ad differ well studi alloster inhibitor ptpb inde biophys measur md simul indic two molecul bind simultan upon bind inhibitor destabil helix disrupt interact interfac prevent format hydrogen bond facilit closur catalyt essenti wpd loop find indic ad promis scaffold build alloster inhibitor ptpb illustr broad unfunction terpenoid engag specif interact protein surfac | D013729;D056004 | T066;T044;T109;T123 |
36,223,518 | attitud indian medic nurs student toward euthanasia cross section survey cross section survey carri among medic interne n nurs student n investig attitud toward euthanasia data collect administ euthanasia attitud questionnair find reveal major particip support euthanasia yet ethic dilemma prevail among student activ passiv euthanasia legal euthanasia age gender religion educ exposur patient requir euthanasia signific differ euthanasia attitud p therefor strong recommend health care student receiv ethic educ prepar deal euthanasia relat issu profession practic | D005065;D013337;D013338 | T058;T097 |
36,223,517 | gaug class cast differ mortal indian experi studi exposit class cast base differ mortal experi base indic call household preval death involv death case collect nation famili health survey analys use relat depriv index rdi found preval death found india vari across state social econom group rdi valu depict poorer household along social group ident like schedul tribe schedul cast household display uniform disadvantag regard mortal across mani state analysi offer evid differenti experi mortal across socio econom ident evid suggest poorer state mark disadvantag along social econom class | D012923 | T098;T080 |
36,223,511 | depsid bond format starter unit acyltransferas domain fungal polyketid synthas depsid polyphenol molecul compris two phenol acid deriv link ester bond call depsid bond molecul despit centuri intens research depsid biosynthet mechan depsid bond format remain unclear studi discov polyketid synthas drca fungus aspergillus duricauli cbs found drca synthes cj heterodimer depsid compos methylorsellin acid dimethylorsellin acid moreov determin depsid bond format catalyz starter unit acyltransferas sat domain drca remark previous undescrib form sat domain chemistri investig reveal transform duricamidepsid depsid amino acid conjug singl modul nonribosom peptid synthetas drcb | D048630;D053630 | T109;T126;T116 |
36,223,503 | emerg pharmacolog intervent pre eclampsia treatment pre eclampsia serious pregnanc complic major global concern mortal mother fetus exist symptomat treatment delay diseas progress thus time deliveri babi effect measur howev risk various matern fetal injuri remain | D011225 | T046 |
36,223,499 | scalabl model free detect spatial pattern coloc expediti growth spatial omic technolog enabl profil genom wide molecular event molecular singl cell resolut highlight need fast reliabl method character spatial pattern develop spagen model free method discov spatial pattern rapid larg scale spatial omic studi analyz simul varieti spatial resolv transcriptom data show spagen power scalabl exist method spatial express pattern identifi spagen reconstruct unobserv tissu structur spagen also success discov ligand receptor interact coloc | D020869;D059467 | T059;T081;T063;T086 |
36,223,494 | antitumor activ zinc oxid nanoparticl coat low molecular weight heparin doxorubicin complex vitro vivo various metal oxid nanomateri wide use carrier prepar ph sensit nanomedicin respond acid tumor microenviron promot antitumor effici herein use zinc oxid nanoparticl zno nps metal oxid nanomateri coat low molecular weight heparin lmhp doxorubicin dox complex lmhp dox prepar zno ld nps control ph trigger dox releas target site result indic releas dox zno ld nps ph sensit oxygen produc zno ld nps h solut observ vitro experi zno ld nps enter pc tumor cell via clathrin mediat endocytosi micropinocytosi pathway intracellular reactiv oxygen speci ros generat zno ld nps could signific increas caspas level lead tumor cell apoptosi vitro vivo antitumor activ confirm pc cell line tumor bear mice model vivo vitro tumor imag via second order nonlinear zno ld nps indic zno ld nps could penetr deep tumor tissu therefor zno ld nps develop studi could provid effici approach prepar ph sensit nano deliveri system suitabl tumor therapi imag | D015034;D053758;D009369 | T121;T073;T197;T191 |
36,223,493 | immunoaffin plastic blade spray mass spectrometri rapid confirmatori analysi food contamin lack chromatograph separ ambient direct mass spectrometri ms ionize techniqu jeopard overal select develop method incorpor biosens element ionize sourc could compens inher lack select thus simplifi immunoaffin direct ms techniqu develop immunoaffin blade spray ib featur conduct polystyren blade materi ib generic coat use convent coat blade spray replac layer high specif monoclon antibodi mab stainless steel replac conduct polystyren allow simpl elisa platelik hydrophob immobil mab high relev climat chang induc food safeti issu mycotoxin deoxynivalenol chosen model substanc follow rapid extract wheat flour immuno captur blade posit front ms direct ib msms analysi method applic demonstr analyz spike incur wheat flour sampl omit need time consum chromatograph separ apart cross react conjug could success analyz well direct ib msms method generic adapt detect analyt sampl extract provid specif mab avail | D053719;D043183 | T047;T063 |
36,223,492 | genet encod whole cell biosensor drug discoveri hif interact inhibitor heterodimer transcript factor hypoxia induc factor hif import anticanc target support adapt respons tumor hypoxia optim repress transactiv yeast two hybrid system develop part versatil yeast base drug discoveri platform valid use hif demonstr fluoresc base auxotrophi base select could detect hif hif dimer inhibit engin genet select tunabl abl differenti strong weak interact show larg dynam rang stabl differ growth phase furthermor engin mechan control cellular activ target drug effect thorough character part biosensor system argu tool general applic wide array protein protein interact target anticip biosensor use part drug discoveri platform particular screen dna encod new modal drug | D051793;D015374 | T059;T075;T123;T116 |
36,223,491 | ribosom dna instabl potenti caus karyotyp evolut karyotyp refer configur genom set chromosom karyotyp differ speci expect imped various biolog process chromosom segreg meiotic chromosom pair potenti contribut incompat karyotyp rapid chang close relat speci even among popul speci howev forc drive karyotyp evolut poor understood describ uniqu karyotyp drosophila melanogast strain isol seychell archipelago strain lost ribosom dna rdna locus x chromosom chromosom rdna bear chromosom femal carri least one chromosom sourc rdna interest found strain also carri truncat chromosom ys stabli maintain popul despit inabl support male fertil model cytolog analysi suggest chromosom larger negat impact femal fit ys chromosom moreov generat independ strain lack x rdna karyotyp xxi femal xy male strain quick evolv multipl karyotyp two new truncat chromosom similar ys well two independ x chromosom fusion contain deriv rdna fragment elimin femal depend chromosom consid robertsonian fusion frequent occur rdna loci human propos rdna loci instabl may one drive forc karyotyp evolut | D004331;D014998 | T026;T204 |
36,223,488 | precis monitor assess treatment respons sepsi induc acut lung hypoxia nitroreductas activ golgi target fluoresc probe sepsi induc acut lung injuri ali most attribut outbreak reactiv oxygen speci ros make leukocyt infiltr lung result lung hypoxia nitroreductas ntr signific upregul hypoxia common regard potenti biomark assess sepsi induc acut lung hypoxia increas evid show ntr golgi apparatus could induc sepsi induc ali meanwhil prolyl hydroxylas phd inhibitor dimethyloxalylglycin dmog attenu sepsi induc ali increas level golgi ntr improv hypoxia induc factor hif activ yet golgi target probe develop monitor assess treatment respons sepsi induc ali herein report golgi target probe gol ntr monitor assess treatment respons sepsi induc ali map generat ntr probe display high sensit low detect limit ngml good select ntr addit due excel characterist golgi target gol ntr success appli map chang golgi ntr cell zebrafish caus various stimuli import product golgi ntr sepsi induc ali phd inhibitor dmog sepsi induc ali visual precis assess first time assist gol ntr result demonstr practic gol ntr precis monitor assess person treatment respons sepsi induc ali | D005456;D018805 | T047;T046;T130 |
36,223,487 | mitochondrion target triphenylphosphonium base kresoxim methyl analogu synthesi fungicid activ action mechan approach methoxyacryl fungicid complex iii q site inhibitor play crucial role control crop diseas studi triphenylphosphonium tpp driven mitochondrion target strategi use modifi kresoxim methyl scaffold toxicophor side chain develop novel mitochondrion target q fungicid kresoxim methyl analogu exhibit differ fungicid activ depend posit tpp conjug linker length among c show excel characterist superior kresoxim methyl candid fungicid activ enhanc phytophthora capsici remark ec valu notabl hyphal zoospor structur pathogen sever damag treatment action mechan approach reveal might caus signific decreas atp synthesi ros outbreak differ way result also provid new insight contribut target group tpp fungicid activ tpp driven fungicid | D005659 | T131 |
36,223,485 | immers challeng model flavobacterium psychrophilum infect atlant salmon salmo salar l fri flavobacterium psychrophilum causat agent bacteri cold water diseas cwbd rainbow trout fri syndrom rtfs affect salmonid better understand pathogen interact host infect includ support develop resist breed new vaccin treatment press need reliabl reproduc immers challeng model close mimic natur rout infect aim present studi evalu challeng model develop previous rainbow trout use atlant salmon first preliminari challeng conduct atlant salmon n rainbow trout n fri use two f psychrophilum isol collect fish speci respect fish pretreat mgl hydrogen peroxid h thereaft main challeng perform one f psychrophilum isol speci cfuml use larger cohort atlant salmon n rainbow trout n surviv main challeng atlant salmon day post challeng rainbow trout day post challeng mortal progress similar preliminari main challeng speci demonstr reproduc model first immers challeng model f psychrophilum develop success atlant salmon | D005393;D045826;D017686;D020317 | T047;T013 |
36,223,484 | model tsh receptor dimer transmembran domain biophys studi establish thyrotropin tsh receptor tshr undergo posttransl modif includ dimer follow earlier simul tshr transmembran domain tmd monom call tshr tmd trio proceed molecular dynam simul md tshr tmd dimer use improv membran embed model start structur tmd protein extracellular intracellular loop intern water place relat orient model origin generat brownian dynam furthermor model embed dppc lipid bilay solvat water ad salt data md simul studi show dimer subunit stay relat orient distanc ns studi comparison repres conform individu monom dimer conform monom simul show subtl differ repres backbon root mean squar deviat differ conform ligand bind site suggest variabl affin hot spot also reveal compar dock score small molecul ligand includ known tshr agonist antagonist well deriv data add insight tendenc tshr tmd form dimer oligomer structur show differ conform influenc small molecul bind site within tmd | D011989;D013972 | T121;T116;T125;T192 |
36,223,483 | temperatur depend small rna express depend wild genet background caenorhabd briggsa geograph distinct popul adapt temperatur condit local environ lead temperatur depend fit differ popul consist local adapt phylogeograph distinct caenorhabd briggsa nematod show distinct fit respons temperatur genet mechan under local adapt howev remain unresolv investig potenti role small noncod rnas genotyp specif respons temperatur quantifi small rna express use high throughput sequenc c briggsa nematod tropic temper strain genotyp rear three temperatur condit c c c strain repres tropic temper region show signific lower express piwi interact rnas pirna high temperatur primarili map larg mb long pirna cluster chromosom iv also document decreas express g rnas antisens protein code gene genom featur high rear temperatur thermal intoler temper strain genotyp tropic strain genotyp reduc g rna express widespread along chromosom among featur type indic genom wide respons target ego csr g rna pathway strong impact compar g rna pathway implic csr argonaut rna depend rna polymeras ego genotyp depend modul c briggsa g rnas chronic thermal stress work suggest gene regul via small rnas may import contributor evolut local adapt | D002107;D029742 | T116;T204 |
36,223,478 | mpcvd grown nanodiamond microelectrod oxygen plasma activ neurochem applic nanodiamond nds carbon nanomateri diamond core heteroatom defect surfac larg surfac area defect site function group nds make promis materi electrochem sens previous dip coat nd onto carbon fiber microelectrod cfmes found increas sensit coat spars direct grew thin film nd niobium wire use microwav plasma chemic vapor deposit mp cvd provid full surfac coverag nd microelectrod show reliabl perform neurotransmitt detect good antifoul properti improv sensit oxygen plasma etch nd film activ surfac intent add defect oxygen surfac function group fast scan cyclic voltammetri detect dopamin oxygen plasma etch increas sensit nam nam treatment foul test repeat inject serotonin tyramin nd plasma oxid nanodiamond ndo microelectrod maintain current better compar cfmes therefor antifoul biofoul test brain slice show nd microelectrod bare current drop hydrophil ndo microelectrod decreas still much cfmes overal grown nd microelectrod promis neurotransmitt detect excel foul resist wherea oxygen plasma etch slight lower foul resist dramat increas sensit | D058612;D037742 | T104;T073 |
36,223,477 | genom wide associ studi adhes capsul suggest signific genet risk factor adhes capsul shoulder involv loss passiv rang motion associ pain develop spontan obvious injuri incit event pathomechan disord remain elucid known risk factor adhes capsul includ diabet femal sex thyroid dysfunct addit transcript profil pedigre analys suggest role genet identif element genet risk adhes capsul use popul base techniqu provid basi guid person treatment patient base genet profil develop new treatment identif pathomechan | D002062;D012785;D003920;D007037 | T047;T030;T023 |
36,223,471 | pro inflammatori megakaryocyt gene express murin model breast cancer despit abund research demonstr platelet promot tumor cell metastasi whether primari tumor affect platelet produc megakaryocyt remain understudi studi use spontan murin model breast cancer show tumor burden reduc megakaryocyt number size disrupt polyploid singl cell rna sequenc demonstr megakaryocyt tumor bear mice exhibit pro inflammatori phenotyp epitom increas ctsg lcn sa sa transcript protein saa lipocalin level also increas platelet suggest tumor induc alter megakaryocyt pass platelet progeni promot vitro tumor cell invas tumor cell lung colon greater extent platelet wild type anim studi first demonstr breast cancer induc alter megakaryocyt lead qualit chang platelet content may feedback promot tumor metastasi | D008533;D009369 | T191;T025 |
36,223,470 | abc transport msba adopt wide inward open conform e coli cell membran protein current investig deterg extract nativ cellular membran reconstitut artifici liposom nanodisc therebi remov physiolog environ howev truli understand biophys properti membran protein physiolog environ must investig within live cell use spin label nanobodi interrog conform cycl abc transport msba doubl electron electron reson unexpect wide inward open conform msba common consid nonphysiolog state found promin popul escherichia coli cell molecular dynam simul reveal extens later portal open essenti provid access larg natur substrat core lipid bind caviti work pave way investig conform landscap membran protein cell | D018528;D004926;D029968 | T007;T123;T116 |
36,223,466 | actuat tension load dna clamp drive membran tubul membran dynam live organ aris protein adher assembl exert forc cell membran programm synthet materi self assembl dna nanostructur offer capabl drive membran remodel event resembl protein mediat dynam user defin outcom illustr exampl tubular deform liposom dna nanostructur purpos design shape surfac modif self assembl properti howev stimulus respons membran tubul mediat dna reconfigur remain challeng present trigger format membran tube respons specif dna signal actuat membran bound dna clamp open state various predefin close state releas prestor energi activ membran deform show time effici vesicl tubul well membran tube width modul conform chang dna clamp mark solid step toward spatiotempor control membran dynam artifici system | D008081;D049329 | T109;T073 |
36,223,459 | upper cortic layer driven network impair schizophrenia schizophrenia one widespread complex mental disord character impact schizophrenia perform singl nucleus rna sequenc snrna seq neuron dorsolater prefront cortex patient schizophrenia match control addit neuron analyz topograph immunohistochemistri composit analysi snrna seq data reveal reduct abund gabaerg neuron concomit increas princip neuron pronounc upper cortic layer subtyp substanti histolog analysi mani neuron subtyp show extens transcriptom chang mark upper layer gabaerg neuron includ regul energi metabol regul neurotransmiss transcript factor network analysi demonstr development origin transcriptom chang last visium spatial transcriptom corrobor upper layer neuron vulner schizophrenia overal result point toward general network impair within upper cortic layer core substrat associ schizophrenia symptomatolog | D012559 | T048 |
36,223,453 | miniatur invert repeat transpos element drive rapid microrna diversif angiosperm microrna mirna fast evolv endogen small rnas regul organ function behavior anim plant although model de novo mirna biogenesi propos genom mechan drive swift diversif mirna repertoir plant remain elus comprehens analyz phylogenet repres plant speci rang green alga angiosperm systemat identifi de novo mirna event associ mirna loci found mirna deriv invert gene duplic event long termin repeat retrotransposon miniatur invert repeat transpos element mite respect among mirna origin mite especi belong mutat tcmarin pifharbing superfamili predomin genom sourc de novo mirna examin angiosperm six non angiosperm data illustr transposit transcript process mite convert new mirna term mite mirna wherebi proper size mite transcrib therefor becom potenti substrat mirna process machineri transpos intron activ gene analyz putat target gene mirna found target gene mite mirna preferenti associ respons environment stimuli temperatur suggest mite mirna pertin plant adapt collect find demonstr molecular convers mite genom mechan lead rapid continu chang mirna repertoir angiosperm | D035683;D019684 | T123;T002;T114 |
36,223,452 | bioprint human tissu path toward clinic translat three dimension bioprint transform technolog engin tissu diseas model drug screen build tissu organ repair regener replac viewpoint discuss technolog advanc bioprint key remain challeng essenti mileston toward clinic translat | D062028;D066330 | T073;T063 |
36,223,451 | translat gap opportun medic wearabl digit health confluenc advanc biosensor technolog enhanc health care deliveri mechan improv machin learn togeth increas awar remot patient monitor acceler impact digit health across near everi medic disciplin medic grade wearabl noninvas bodi sensor oper clinic accuraci play increas central role medicin provid continu cost effect measur interpret physiolog data relev patient status diseas trajectori insid outsid establish health care set review current digit health technolog highlight critic gap clinic translat adopt | D003695;D000076251 | T093;T058;T073 |
36,223,450 | line miniatur print pressur cycl ventil maintain respiratori homeostasi swine induc acut pulmonari injuri covid pandem demonstr need inexpens easi use rapid mass produc resuscit devic could quick distribut area critic need line miniatur ventil base principl fluidic ventil patient automat oscil forc inspir assist expir airway pressur chang requir continu suppli pressur oxygen design three miniatur ventil model oper specif pressur rang along continuum clinic lung injuri mild moder sever injuri three dimension print prototyp devic evalu lung simul generat airway pressur tidal volum minut ventil within target rang state lung diseas design support test domest swine induct pulmonari injuri ventil mild moder injuri met design criteria match appropri degre lung injuri although ventil sever injuri provid specifi design pressur respiratori rate elev reduc minut ventil result lung complianc design paramet respiratori rate reflect well ventil match injuri state lung could guid select ventil model clinic use simpl devic could help mitig shortag convent ventil pandem disast requir rapid access advanc airway manag transport applic hand free ventil | D055371;D000086382 | T047;T067;T037 |
36,223,449 | minim invas sustain releas relaxin microparticl revers arthrofibrosi substanti advanc biotherapeut distinct lack musculoskelet diseas musculoskelet diseas biomechan complex local highlight need novel therapi capabl address issu frontlin treatment option arthrofibrosi debilit musculoskelet diseas fail treat diseas etiolog accumul fibrot tissu within joint space million patient year lack modern effect treatment option necessit surgeri attempt regain joint rang motion rom escap prolong pain human relaxin rlx endogen peptid hormon antifibrot antifibrogen activ promis biotherapeut candid musculoskelet fibrosi howev rlx previous falter multipl clinic program pharmacokinet barrier describ design vitro character tailor drug deliveri system sustain releas rlx drug load polymer microparticl releas rlx multiweek time frame without alter peptid structur bioactiv vivo intraarticular administr microparticl rat result prolong local concentr rlx reduc system drug exposur furthermor singl inject rlx load microparticl restor joint rom architectur atraumat rat model arthrofibrosi clinic deriv end point final confirm rlx receptor express rxfp multipl human tissu relev arthrofibrosi suggest clinic translat potenti rlx administ sustain target manner | D009140;D012065 | T121;T047;T116;T125 |
36,223,448 | leverag technolog address current futur world issu biotechnolog essenti advanc modern medicin allevi global health crise yet commerci often wrought compet forc | D001709;D014943 | T078;T091 |
36,223,447 | translat diagnost drug deliveri technolog low resourc set diagnost drug deliveri technolog engin low resourc set aim meet technic design specif use strategi compat limit equip infrastructur oper train despit mani preclin success devic translat clinic identifi factor contribut clinic success diagnost drug deliveri system low resourc set includ need engag key stakehold earli stage provid recommend clinic translat futur medic technolog | D016503 | T074 |
36,223,446 | engin human mini bone standard model healthi hematopoiesi leukemia solid tumor metastasi bone marrow microenviron provid indispens factor sustain blood product throughout life also hotspot progress hematolog disord frequent site solid tumor metastasi preclin research reli xenograft mous model model preclud human specif function interact stem cell bone marrow microenviron instead human mesenchym cell exploit vivo engin human nich confer robust engraft human healthi malign blood sampl howev mesenchym cell associ major reproduc issu tissu format report fast standard generat human mini bone custom design human mesenchym cell line result human ossicl hoss consist fulli matur bone bone marrow structur host human mesenchym nich retain stem cell properti compar mous bone demonstr superior engraft human cord blood hematopoiet cell primari acut myeloid leukemia sampl also valid hoss metastat site breast cancer cell report engraft neuroblastoma patient deriv xenograft cell human model recapitul clinic describ osteolyt lesion collect human mini bone constitut power preclin platform model bone develop tumor use patient deriv materi | D015470;D055153 | T191;T022 |
36,223,445 | translat musculoskelet bioengin tissu regener therapi musculoskelet injuri disord lead caus physic disabl worldwid consider socioeconom burden lack effect therapi driven develop novel bioengin approach recent start gain clinic approv review first discuss self repair capac musculoskelet tissu describ caus musculoskelet dysfunct review develop novel biomateri immunomodulatori cellular gene therapi treat musculoskelet disord last consid recent regulatori chang futur area technolog progress acceler translat therapi clinic practic | D001672;D057005 | T090;T122 |
36,223,431 | miniatur chip scale spectromet use local strain engin total variat regular reconstruct wafer thin chip scale portabl spectromet suitabl wearabl applic base reconstruct algorithm demonstr total spectral encod simultan function photodetector monolith integr chip area mm appli local strain engin compress strain ingangan multipl quantum well heterostructur built gan pn junction enabl direct photocurr measur non negat least squar nnls algorithm total variat regular choic proper kernel function shown deliv decent spectral reconstruct perform wavelength rang nm accuraci spectral peak posit intens ratio peak found respect extern optic collim optic apertur use enabl angl insensit light harvest structur includ array cone shape backreflector fabric undersid sapphir substrat | D005708 | T196 |
36,223,430 | role heme oxygenas dual stress respons herbicid micronutri fe arabidopsi thaliana increas intens agricultur practic lead herbicid contamin also nutrit stress nontarget plant studi evalu role heme oxygenas ho dual stress respons herbicid dichlorprop micronutri fe arabidopsi thaliana result reveal co treatment zinc protoporphyrin specif inhibitor ho reduc activ ho fe content mda content reduc abnorm iron aggreg oxid stress respons herbicid compar treatment r dichloroprop alon herbicid activ thus free fe releas ho mediat dichlorprop induc oxid stress fenton reaction affect aberr fe aggreg also enantioselect effect studi contribut depth understand toxic mechan herbicid nutrient stress thus provid new strategi control environment risk herbicid | D006540;D017360;D014131 | T002;T131;T121;T123;T196 |
36,223,427 | inhibitor apiap protein dna bind exhibit multistag activ plasmodium parasit plasmodium parasit reliant apicomplexan ap apiap transcript factor famili regul gene express program ap dna bind domain homolog human mosquito host genom make potenti antimalari drug target use silico screen dock thousand small molecul crystal structur ap exp pfd ap domain pdbigm identifi putat ap exp interact compound four compound found block dna bind ap exp least one addit apiap protein top apiap competitor compound perturb transcriptom p falciparum trophozoit result decreas abund log fold chang ap exp target gene addit two apiap competitor compound multi stage anti plasmodium activ blood mosquito stage parasit summari describ novel set antimalari compound interact ap dna bind domain compound may use futur chemic genet interrog apiap protein serv start point new class antimalari therapeut | D000962;D010961;D004268 | T121;T123;T116;T204 |
36,223,426 | assess qualiti antenat care pregnanc outcom tertiari hospit ghana antenat care anc imper decreas advers pregnanc outcom relat matern mortal howev sub saharan africa increas anc coverag correl well improv matern fetal outcom suggest qualiti anc receiv could miss link studi assess anc qualiti effect advers pregnanc outcom among women deliv komfo anoky teach hospit | D011256;D011295 | T058;T033 |
36,223,422 | factor associ comprehens knowledg antenat care attitud toward uptak among women deliv home rural sehala seyemit district northern ethiopia communiti base cross section studi despit current sustain develop goal period ie sdg prevent matern neonat mortal satisfactori ethiopia keep women knowledg antenat care maintain posit attitud toward uptak particular margin rural communiti crucial howev evid regard knowledg attitud women toward antenat care uptak scarc therefor studi aim assess factor affect comprehens knowledg antenat care attitud toward uptak among women deliv home rural sehala seyemit district northern ethiopia | D011295;D012424 | T098;T058;T102 |
36,223,421 | arbovirus unappreci caus non malari acut febril ill dschang health district western cameroon acut febril ill common problem manag clinician health system global particular tropic mani region malaria lead potenti dead caus fever howev myriad altern etiolog exist identifi caus fever allow optim manag depend mani factor includ thorough knowledg circul infect arbovirus dengu denv caus fever may underdiagnos sub saharan africa malaria major focus examin case fever western cameroon test negat malaria found due denv denv serotyp infect two complet denv genom obtain cluster close recent isol seneg burkina faso seropreval denv region neutral antibodi denv detect seroposit sampl test chikungunya chikv arthritogen alphavirus transmit aed mosquito princip vector denv seropreval chikv howev chikv caus singl case fever subject test note seroposit one arbovirus associ seroposit p taken togeth data indic aed transmit arbovirus endem western cameroon like common underappreci caus febril ill work support need addit studi arbovirus sub saharan africa effort improv diagnost capac surveil system arbovirus prevent strategi | D001103;D003715;D060085;D065632;D000330;D008288 | T047;T005;T204 |
36,223,420 | data driven identif intern cut edg scienc technolog use spaci difficulti collect process identifi massiv data slow research cut edg scienc technolog hotspot promot technolog success without effect data driven method identifi cut edg technolog paper propos data driven model identifi global cut edg scienc technolog base spaci model collect data releas well known american technolog media websit juli juli use web crawl python combin graph base neural network learn activ learn research method paper next introduc ten fold cross check train model machin learn repeat experi experiment result show model perform well entiti recognit task f valu model provid inform sourc cut edg technolog identif promot innov cut edg technolog effect identif track explor effici scientif technolog research work mode | D016571;D013672 | T090;T170 |
36,223,419 | serinc restrict influenza virus infect serinc multi span transmembran protein incorpor hiv particl produc cell inhibit hiv entri multipl retrovirus like hiv equin infecti anemia virus murin leukemia virus subject serinc inhibit hiv pseudotyp envelop glycoprotein vesicular stomat virus ebola virus resist serinc antivir spectrum under mechan serinc restrict complet understood show serinc inhibit influenza virus infect target virus cell membran fusion earli step infect result show differ influenza hemagglutinin ha subtyp exhibit divers sensit serinc restrict analysi amino acid sequenc influenza ha strain indic ha glycosyl site correl sensit influenza ha serinc inhibitori effect serinc lost certain ha glycosyl site mutat studi expand antivir spectrum serinc also reveal role viral envelop glycosyl resist serinc restrict | D007251;D015497;D009975 | T047;T005 |
36,223,418 | work digit economi systemat review impact work home arrang person organiz perform product work home becom increas adopt practic global given emerg covid pandem arrang risen substanti short timefram work home associ sever physic mental health outcom relationship support previous research howev health safeti issu often receiv littl resourc attent busi perspect compar organiz worker perform product therefor align work home practic busi goal may help catalyz awar decis maker serv effect implement work home polici conduct review synthes current knowledg impact work home arrang person organiz perform product four larg databas includ scopus pubm psychinfo busi sourc complet systemat search two step screen process select extract data relev articl key search term surround two core concept work home productivityperform articl publish prior covid pandem n demonstr work home increas product perform wherea n show mix effect articl publish pandem n show posit effect n reveal mix result n show negat effect find suggest non mandatori work home arrang posit impact product perform work home becom mandatori full time extern factor ie covid pandem play overal impact less posit detriment product perform result help foster understand impact work home product perform inform develop organiz strategi creat effect resili inclus work home workplac help effect implement work home polici align busi goal | D000086382;D058873 | T047;T067 |
36,223,417 | relationship spiritu health engag health belief attitud toward accept willing pay covid vaccin explor wider determin factor citizen spiritu health engag health belief model attitud toward vaccin toward accept willing pay coronavirus diseas covid vaccin | D000086382;D000086663 | T047;T200;T067 |
36,223,416 | biogasif methanol extract lignit residu case studi yima coalfield china investig bioga generat characterist organ matter lignit methanol extract conduct obtain solubl fraction residu lignit subsequ taken sole carbon sourc bioga product methanogen consortium afterward composit compound ferment character uv vis gc ms hplc ms analysi result indic methanogen microorgan could produc h co without accumul ch util extract methan product residu larger raw lignit reach mmolg moreov organ compound methanol extract degrad molecular weight reduc compound dimethyl methylethyl naphthalen butyl hexylnaphthalen simonellit reten complet degrad microorgan addit aromat non aromat metabolit produc biodegrad detect may negat effect methanogenesi process result reveal complex interact coal organ anoth point view | D019605;D000432 | T109;T131;T130;T194 |
36,223,415 | factor influenc implement health promot intervent workplac protocol scope review health promot intervent workplac effect modifi lifestyl relat behavior risk factor non communic diseas ncds howev intervent alway success real world set evid effect strategi implement intervent limit propos scope review identifi topic need studi area futur research barrier facilit implement workplac health promot intervent | D012107;D017132 | T081;T082;T170;T169;T062;T096 |
36,223,414 | inhibit rip rip mediat necroptosi attenu renal fibrosi via wnt cateningsk signal unilater ureter obstruct renal fibrosi repres final common outcom chronic kidney diseas virtual etiolog howev mechan under evolut renal fibrosi remain address studi sought clarifi whether rip rip mediat necroptosi involv renal fibrosi via wnt cateningsk signal vitro rat model unilater ureter obstruct uuo rat uuo administ rip inhibitor necrostatin gsk catenintcf inhibitor icg daili consecut day uuo caus signific renal tubular necrosi overexpress rip rip mlkl axi protein accompani activ nlrp inflammasom renal fibrosi oxid stress caus uuo close associ endoplasm reticulum stress mitochondri dysfunct result apoptot cell death via wnt cateningsk signal effect abolish rip inhibitor necrostatin gsk icg ho treat hk cell rip inhibitor icg decreas intracellular reactiv oxygen speci product apoptot cell increas cell viabil activ wnt cateningsk signal decreas either rip inhibitor icg find suggest rip rip mediat necroptosi contribut develop renal fibrosi via wnt cateningsk signal uuo may therapeut target protect renal scar origin | D007674;D053422;D014517 | T047;T126;T116 |
36,223,411 | proteom coupl vitro model studi earli crosstalk occur newli excyst juvenil fasciola hepatica host intestin cell fasciolosi caus trematod fasciola hepatica zoonot neglect diseas affect anim human worldwid infect occur upon ingest aquat plant water contamin metacercaria releas newli excyst juvenil fhnej host duodenum establish contact epithelium cross intestin barrier reach peritoneum within h infect juvenil crawl peritoneum toward liver migrat hepat tissu reach definit locat insid major biliari duct matur adult worm fasciolosi treat triclabendazol although resist isol parasit increas report togeth limit efficaci assay vaccin infect pose fasciolosi veterinari human health problem grow concern context studi earli host parasit interact paramount import definit new target treatment prevent fasciolosi develop new vitro model replic first interact fhnej mous primari small intestin epitheli cell mpsiec fhnej mpsiec co incub h protein extract tegument soma fhnej membran cytosol mpsiec subject quantit swath ms proteom compar respect control mpsiec fhnej left alon h cultur medium evalu protein express chang parasit host result show interact fhnej mpsiec trigger rapid protein express chang fhnej respons host epitheli barrier includ cathepsin l l sever immunoregulatori protein regard mpsiec stimul fhnej result alter protein profil relat immunomodul cell cell interact togeth drastic reduct express protein link ribosom function molecul identifi model earli host parasit interact could help defin new tool fasciolosi | D005210;D005211;D040901 | T047;T091;T204 |
36,223,408 | tiam differenti regul dendrit axon microtubul organ pattern neuron develop multipl domain axon dendrit develop requir cooper actin microtubul cytoskeleton microtubul form well organ network direct polar traffick support neuron process format distinct actin structur howev larg unknown cytoskeleton regul differenti regul microtubul organ axon dendrit develop character role actin regul axon dendrit develop show racgef tiam regul dendrit pattern n termin domain suppress axon growth c termin domain tiam maintain plus end microtubul orient posterior dendrit prevent accumul microtubul axon somatodendrit region tiam interact unc stabil organ actin filament microtubul unc requir tiam control axon growth express level determin axon length taken togeth tiam regul neuron microtubul organ pattern axon dendrit develop respect differ domain | D003712;D000199 | T026;T123;T116 |
36,223,405 | manufactur produc servic agglomer affect urban innov differ empir evid china despit grow bodi literatur influenc industri agglomer urban innov consensus reach mechan spillov effect empir studi exploit heterogen spillov effect manufactur produc servic agglomer urban innov base sampl prefectur level citi china find intrigu new find threshold effect identifi spillov effect manufactur agglomer produc servic agglomer manufactur produc servic agglomer opposit decomposit indirect effect spatial spillov effect industri agglomer restrain absorpt capac nearbi citi studi provid empir evid reconcili debat effect manufactur produc servic agglomer also import polici implic reconsid role industri agglomer urban innov | D003132;D007221 | T078;T097;T081;T057 |
36,223,404 | hdac inhibitor aci show lung epitheli protect featur copd airway epitheli damag common featur respiratori diseas copd suggest drive inflamm progress diseas featur manifest remodel destruct lung epitheli characterist includ loss small airway contribut chronic airway inflamm histon deacetylas hdac shown play role epitheli function dysregul cilia disassembl epitheli mesenchym transit emt oxid stress respons implic sever diseas thus use aci inhibitor high select hdac character effect epitheli function includ epitheli disrupt cytokin product remodel mucociliari clearanc cell characterist primari lung epitheli air liquid interfac cultur copd patient use impact tnf tgf cigarett smoke bacteri challeng epitheli function presenc absenc aci test challeng increas permeabl epitheli barrier whilst aci block effect even decreas permeabl absenc challeng tnf also shown increas product cytokin mucin aci reduc effect observ copd relev stimul creat damag epithelium seen immunohistochemistri section treatment aci maintain intact cell layer preserv mucociliari function interest direct effect ciliari beat frequenc tight junction protein indic mechan protect epithelium summari aci show protect respiratori epithelium copd relev challeng indic futur potenti restor epitheli structur function halt diseas progress clinic practic | D056572;D029424 | T121;T047;T126;T116 |
36,223,403 | phenotyp variat biomass relat trait among four generat advanc line cleom gynandropsi gynandra l briq gynandropsi gynandra spider plant african tradit leafi veget rich miner vitamin health promot compound potenti health promot micronutri supplement incom generat stakehold includ pharmaceut compani howev inform biomass product limit consequ constrain breeder abil select high yield genotyp end user make decis suitabl cultiv product system studi aim assess phenotyp variabl biomass relat trait collect g gynandra advanc line select elit genotyp improv cultivar develop seventi one advanc line select access origin asia west africa east africa southern africa evalu two year two replic greenhous use x alpha lattic design signific statist differ observ among line genotyp origin fourteen biomass relat trait result reveal three cluster cluster domin line deriv access asia cluster west africa cluster eastsouthern africa cluster west african eastsouthern african group compar biomass product superior asian group specif west african group low number long primari branch high dri matter content flower earli eastsouthern african group character broad leav late flower high number short primari branch medium dri matter content candid cultivar releas mainten line membership group origin strengthen hypothesi geograph signatur cleom divers genet driver observ variat high genet varianc broad sens herit genet gain show potenti improv biomass yield relat trait signific posit correl among biomass per plant plant height stem diamet leaf size show potenti simultan direct select farmer desir trait present result provid insight divers spider plant genotyp biomass product repres key resourc improv speci | D031485;D019684 | T002 |
36,223,402 | supramolecular organ framework adsorb effici remov excess bilirubin hemoperfus excess bilirubin accumul bodi patient suffer acut liver failur alf caus much irrevers damag bring serious clinic symptom kernicterus hepat coma even death hemoperfus wide use method remov bilirubin blood clinic use adsorb unsatisfactori adsorpt capac kinet studi prepar four supramolecular organ framework microcryst sof via slow evapor aqueous solut infrar light sof possess good regular excel stabil demonstr four sof could serv adsorb bilirubin fast adsorpt kinet within min ultrahigh adsorpt capac mg g driven electrostat interact hydrophob superior adsorpt perform sof outperform report bilirubin adsorb remark sof could remov bilirubin presenc g l bsa minim loss albumin thus process bead shape composit diamet mm poli ether sulfon pes pes load sof could effici adsorb bilirubin normal level human plasma adsorpt equilibrium concentr mg l h dynam hemoperfus process work provid new vital develop novel bilirubin adsorb hemoperfus therapi | D001663;D006464 | T121;T061;T109;T123 |
36,223,401 | new buffer theori social support psycholog stress dynam model link stress social support health recent propos numer analyz classic point view integ order calculus although interest observ obtain way present work conduct fraction order analysi model period forc environment stress variabl perceiv stress analyz bifurc diagram two well known metric entropi complex spectral entropi c complex result obtain numer simul shown novel insight stress evolv frequenc amplitud perturb well initi condit system variabl precis observ stress altern chao period oscil stabl behavior fraction order vari moreov perturb frequenc reveal narrow interv chaotic oscil amplitud may present differ valu indic low sensit regard chao generat also perceiv stress note high sensit initi condit symptom stress relat ill health social support receiv famili friend work open new direct research wherebi fraction calculus might offer insight psycholog life scienc mental disord stress free well | D002137;D017711 | T170;T031;T077 |
36,223,400 | systemat review qualiti apprais econom evalu schistosomiasi intervent schistosomiasi neglect tropic diseas ntd affect million peopl low middl incom countri lmic lead long term debilit health effect associ impoverish prioritis world health organ prevent control elimin systemat review aim identifi evalu exist econom evalu intervent tackl schistosomiasi | D012552 | T047 |
36,223,399 | genet environment driver larg scale epigenet variat thlaspi arvens natur plant popul often harbour substanti herit variat dna methyl howev thorough understand genet environment driver epigenet variat requir larg scale high resolut data current exist model speci studi line annual weed thlaspi arvens field pennycress collect across larg latitudin gradient europ propag common environ screen variat dna sequenc dna methyl use whole genom bisulfit sequenc found signific epigenet popul structur across europ averag level dna methyl strong context depend highest dna methyl cg context particular transpos element intergen region residu dna methyl variat within context associ genet variant often co local annot methyl machineri gene also new candid variat dna methyl also signific associ climat origin methyl level lower colder region variabl climat final use varianc decomposit assess genet versus environment associ differenti methyl region dmrs found genet variat general strongest predictor dmrs strength environment associ increas cg chg chh climat origin strongest predictor one third chh dmrs summari data show natur epigenet variat thlaspi arvens signific associ dna sequenc environ origin relat import two factor strong depend sequenc context dna methyl arvens emerg biofuel winter cover crop result may henc relev breed effort agricultur practic context rapid chang environment condit | D031227 | T002 |
36,223,398 | mani foliar endophyt fungi quercus gambelii capabl psychrotoler saprotroph growth mani endophyt fungi potenti function saprotroph live host tissu senesc enter litter pool consumpt plant litter fungi obvious requir moistur arid western usa nativ rang quercus gambelii nutt precipit occur coldest month year therefor hypothes endophyt fungi q gambelii potenti function psychrotoler saprotroph defin studi organ capabl signific growth leaf litter c hypothes tradeoff exist growth endophyt fungi c c fungal isol either cold warm temperatur specialist consist first hypothesi found isol consum leaf litter c surpris high degre variabl among isol abil even among isol given speci contrari second hypothesi tradeoff saprotroph growth c saprotroph growth c inde isol grew poor saprotroph c general grew poor saprotroph c virtu endophyt endophyt fungi prioriti litter decompos fungi colon plant tissu enter litter pool moreov virtu psychrotoler endophyt fungi may function saprotroph cold month year moistur temporarili avail therefor suggest endophyt fungi q gambelii could play signific ecosystem role litter decomposit nutrient cycl | D029963 | T002 |
36,223,397 | catch throw exercis improv reactiv balanc random control trial protocol comparison aquat dri land exercis environ reactiv balanc critic automat movement pattern respons perturb direct link fall prevent older adult various exercis intervent broad perform improv reactiv balanc thus prevent fall curious aquat exercis suggest effect balanc intervent safer altern exercis dri land yet efficaci aquat exercis reactiv balanc formal investig present clinic trial aim identifi skill acquir aquat exercis effect transfer reactiv balanc task land exercis studi design doubl blind random control clinic trial forti four older adult age year meet elig criteria recruit random aquat exercis group land exercis group group particip singl bout intervent includ ball throw catch task modifi lean releas test implement land immedi one week singl bout intervent outcom includ reaction time rapid respons accuraci mini bestest score obtain step grasp reaction statist analys conduct use intent treat approach conceptu hypothesi particip aquat exercis group demonstr improv outcom score lean releas test compar land exercis group result present studi expect provid evid support benefit aquat exercis improv reactiv balanc older adult particip may find aquat exercis safer motiv thus encourag particip aquat exercis program | D005081;D004856 | T061;T040 |
36,223,396 | genom character francisella tularensi divers francisella speci complex sampl francisella tularensi bacterium caus zoonosi tularemia genet near neighbor speci difficult imposs cultiv complex sampl thus lack genom inform speci among thing limit develop robust detect assay f tularensi specif sensit object studi develop valid approach captur enrich sequenc analyz francisella dna present dna extract generat complex sampl rna captur probe design base upon known pan genom f tularensi divers speci famili francisellacea probe target genom region also present non francisellacea speci exclud probe specif particular francisella speci phylogenet clade identifi captur enrich system appli divers complex dna extract contain low level francisella dna includ human clinic tularemia sampl environment sampl ie anim tissu air filter whole tickstick cell line follow sequenc enrich sampl analysi result data facilit rigor unambigu confirm detect f tularensi francisella speci complex sampl identif mixtur differ francisella speci sampl analysi gene content eg known virul antimicrobi resist loci high resolut whole genom base genotyp benefit captur enrich system includ even low target dna amplifi cultur independ reduc exposur research andor clinic personnel allow genom inform obtain sampl yield isol result comprehens data provid robust mean confirm presenc target speci sampl also provid data use sourc attribut import genom epidemiolog perspect | D000890;D005604;D014406 | T121;T007;T047 |
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