PMID
int64 35.7M
36.4M
| Title/Abstract
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36,331,155
|
preval mortal among patient copd hospitalis ambul period sever exacerb chronic obstruct pulmonari diseas copd may requir acut medic attent call emerg medic servic em ambul day mortal em patient respiratori diseas appear stagnat may due chang age comorbid diseas sever examin trend occurr sever mortal em patient copd
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D000552;D029424
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T047;T074;T073
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36,331,154
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introduct free hand mri guid transperin prostat biopsi outpati procedur direct biopsi prostat use diagnos prostat cancer prostat biopsi perform transrect ultrason guidanc trus bx transrect approach carri risk sepsi bacteria may transfer direct prostat rectum approxim patient hospitalis within seven day trux bx increas antibiot resist spur renew interest transperin approach tp bx asept tp bx may perform signific reduc risk infect describ first danish experi multiparametr mri guid freehand tp bx
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D011467;D011471
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T023;T191
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36,331,153
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routin x ray chest justifi stage patient primari breast cancer chest x ray cxrs perform routin part stage primari breast cancer patient breast unit denmark howev sever intern studi found exceed low detect rate occult pulmonari metastat diseas among breast cancer patient even data previous publish danish patient
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D001943;D008175
|
T191
|
36,331,152
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high protein diet pulmonari rehabilit patient chronic obstruct pulmonari diseas preval cachexia patient chronic obstruct pulmonari diseas copd high associ reduc qualiti life increas mortal morbid aim test effect high protein diet combin exercis fat free mass ffm function capac symptom burden dyspnoea
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D000073600;D029424
|
T061;T047
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36,331,151
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problem self manag analges outpati shoulder surgeri surgic outpati instruct use analges post oper mani fail obtain adequ pain control home studi describ medic taken relat prescrib medic pain intens improv recommend drug choic schedul also describ error occur suggest improv patient educ adher
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D000073278;D018712
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T121;T058
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36,331,150
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chemosensori function food prefer among haemodialysi patient malnutrit disturb sens smell tast frequent occur patient treat chronic haemodialysi common denomin chemosens nutrit may food prefer aim investig smell tast function well food prefer among haemodialysi patient compar result age match control
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D005518;D013649
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T055;T042;T080
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36,331,149
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anxieti among medic student junior doctor denmark intern studi document medic educ transit student medic doctor may stress difficult time high anxieti level impact profession perform qualiti life aim studi investig preval anxieti among danish final semest medic student newli graduat medic doctor includ individu chang
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D013337
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T097
|
36,331,144
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clinic outcom hybrid close wedg high tibial osteotomi advanc osteoarthr knee compar total knee arthroplasti evalu clinic outcom hybrid close wedg high tibial osteotomi hcwhto total knee arthroplasti tka advanc medial compartment osteoarthr knee advanc knee oa
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D019645;D020370
|
T061;T047
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36,331,045
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complet intervent extracardiac fontan extracardiac fontan complet via transcathet perfor pericardi membran creat preparatori stage thus establish continu inferior vena cava pulmonari arteri step follow deploy cover stent isol system pulmonari circuit procedur avoid morbid associ cardiac reoper safe option patient present late prohibit pulmonari arteri pressur primari fontan complet may feasibl
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D018729;D006330
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T061;T019;T042
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36,331,027
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role gadda myocardi ischemiareperfus mediat jnkp mapk statvegf pathway rapid recoveri block coronari arteri blood flow myocardi infarct mi key reduc size infarct area improv clinic outcom decreas mortal howev ischemiareperfus ir injuri complic patholog mechan inevit complic coronari arteri blood flow recoveri growth arrest dna damageinduc gadda serv vital role myocardi injuri induc ir present studi aim explor role mechan gadda cardiac microvascular endotheli cell cmec ir injuri vivo vitro ir injuri rat model hypoxiareoxygen hr cellular model establish myocardi tissu collect gadda detect triphenyltetrazolium chlorid stain h e stain dual stain cd tunel serum also collect analysi creatin kinas lactat dehydrogenas ir rat follow gadda silenc addit protein express level cd phosphorylatedendotheli nitric oxid synthas peno endothelin et jnk p mapk stat vegf assess western blot jnk p mapk activ anisomycin jakstat pathway inhibitor ag use determin involv jnkp mapk pathway statvegf pathway gadda high express ir injuri rat cell model gadda silenc reduc ischem area improv myocardi patholog damag vivo furthermor level cd peno increas wherea et decreas gadda silenc ir injuri rat mechanist gadda silenc reduc jnkp mapk express activ statvegf express gadda silenc inhibit hrinduc viabil reduct apoptosi mapk signal suppress angiogenesi via statvegf hrinduc cmec overal gadda amelior apoptosi function injuri cmec via jnkp mapk statvegf pathway
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D015428;D017202;D009203
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T047;T046
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36,331,022
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antihypertens effect astragalosid iv cerebr ischemia reperfus rat stroke one lead caus death diseas blood suppli brain tissu interrupt neuron core death occur due lack glucos oxygen min blood pressur lower ischem stroke proven effect strategi achiev neurovascular protect reduc risk recurr stroke astragalosid iv pure small molecular compound isol radix astragali well document astragalosid iv neuroprotect effect cerebr ischemia reperfus cir injuri mani mechan includ antioxid antiinflammatori antiapoptot present studi adopt mean arteri pressur map monitor neurolog score triphenyltetrazolium chlorid stain enzymelink immunosorb assay western blot experiment method investig effect astragalosid iv system blood pressur cir middl cerebr arteri occlus anim model demonstr astragalosid iv pretreat signific allevi cir injuri previous report addit elev map cir signific inhibit astragalosid iv administr moreov reveal express nakcl cotransport isoform hypothalamus inhibit subsequ synthesi vasopressin reduc astragalosid iv pretreat cir anim model conclus astragalosid iv may allevi cir injuri partial lower system blood pressur
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D012503;D014315;D002545;D015427
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T047;T046;T037;T109
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36,330,921
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movement disord caus frrsl defici may associ morpholog function disord purkinj cell ferric chelat reductas like frrsl protein identifi auxiliari regulatori protein amino hydroxi methyl isoxazol propion acid receptor ampar frrsl high express cerebellum brain region associ control motor function loss frrsl shown lead impair synapt transmiss via ampar movement disord found delet frrsl gene caus hyperact reduc muscl strength impair coordin ataxia mice delet also impair purkinj cell dendrit spine format ampar express cerebellum damag electrophysiolog discharg rhythm purkinj cell cerebrospin fluid examin oleic acid oa induc lipid accumul monitor frrsl knockdown sh syy cell indic frrsl defici could lead aberr metabol amino acid glucos lipid summari found delet frrsl lead impair motor coordin cerebellar ataxia mice might relat reduc express ampar metabol deviat dysplast function defect purkinj cell
|
D009447;D009069
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T047;T191
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36,330,895
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intra tumor heterogen prognost risk signatur hepatocellular carcinoma base singl cell analysi intra tumor heterogen pose serious challeng treatment cancer includ hepatocellular carcinoma hcc recent develop singl cell rna sequenc scrna seq make possibl examin heterogen tumor cell gene express omnibus geo databas retriev obtain scrna seq data hcc para cancer sampl cell cluster use findneighbor findclust function cell subset defin use enrich function clusterprofil packag monocl use predict cell development trajectori limma packag includ r program util detect differenti express gene deg hcc paracancer tissu univari cox analysi least absolut select oper lasso cox regress analysi conduct establish risk assess model thirteen cell subpopul identifi sequenc data singl cell four cell subgroup dendrit cell hepatocyt liver bud hepat cell liver progenitor cell tumor tissu high enrich hcc para cancer tissu deg identifi specif marker four cell subgroup develop prognost risk model gene among gene select train valid set model demonstr higher year auc independ serv prognost marker confirm multivari univari cox analys studi reveal characterist differ cell subpopul immun cell tumor cell hcc microenviron establish novel nine gene prognost model determin death risk hcc patient discoveri research improv current knowledg hcc heterogen may inspir futur research
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D006528;D008113
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T191
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36,330,853
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organ solvent aggreg shape structur fold protein case studi proteas enzym low solubl reactant product aqueous solut result enzymat catalyt reaction occur non aqueous solut current studi investig aqueous solut contain differ organ solvent deep eutect solvent dess influenc proteas enzym activ structur thermal stabil retrovir aspart proteas enzym respons cleavag polypeptid precursor matur viral compon crucial step virus life cycl molecular dynam simul mds complex proteas enzym darunavirwa found high stabl urea aqueous solut compar ethylen glycol eg glycerol solvent particular differ organ solvent presenc darunavir induc protein protein interact within proteas homodim system eg glycerol solvent flap domain enzym form open conform lead weak bind affin drug conserv g residu among famili aspart proteas enzym made stabl bind darunavir urea system unfold proteas dimer initi due self aggreg eg glycerol organ solvent form open conform flap domain contrari lack cluster urea solvent proteas show convent structur fold presenc absenc drug molecul novel find may help better understand proteas enzym could control deep eutect solvent
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D005990;D019855
|
T123;T121;T131;T109
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36,330,843
|
explor primari healthcar practition experi regard coronavirus diseas covid pandem kwazulu natal south africa coronavirus diseas covid spread rapid around world sinc initi outbreak wuhan china emerg omicron variant south africa present epicentr covid pandem sub saharan africa healthcar worker forefront pandem term screen earli detect clinic manag suspect confirm covid case sinc begin outbreak littl report healthcar worker experienc covid pandem south africa particular within low incom rural primari care context
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D058873;D000086382
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T047;T067
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36,330,835
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parent childhood vaccin hesit predict uptak vaccin systemat review review aim identifi relev quantit research parent childhood vaccin hesit vaccin uptak vaccin intent relev outcom map gap knowledg vaccin hesit develop suggest research guid intervent field
|
D000088823;D014612
|
T129;T055;T121;T116
|
36,330,824
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scenario model analysi anticip impact covid vaccin adolesc children diseas outcom netherland summer backgroundsinc roll covid vaccin late throughout european govern reli mathemat model inform polici decis covid vaccinationaimw present scenario base model analysi netherland summer inform whether extend vaccin adolesc year old children year old methodsw develop determinist age structur suscept expos infecti recov seir model compar model incid infect hospit intens care admiss death per peopl across vaccin scenario emerg omicron variantresultsour model project show averag upon releas non pharmaceut control measur novemb larg covid wave may occur winter follow smaller second wave spring regardless vaccin scenario model project reduct infectionssever diseas outcom vaccin extend adolesc reduct vaccin extend peopl year old examin project diseas outcom age group individu benefit extend vaccin adolesc children also observ reduct diseas outcom older age group particular parent age year children adolesc vaccin suggest prevent onward transmiss younger older age groupsconclusionswhil scenario could anticip emergenceconsequ sar cov omicron variant illustr approach assist decis make could use consid provid booster dose interven futur infect wave
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D000086402;D000086382
|
T005;T067;T047
|
36,330,823
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ongo toxin posit diphtheria outbreak feder asylum centr switzerland analysi juli septemb two diphtheria outbreak occur swiss asylum center juli octob one still ongo outbreak main involv minor includ six symptomat respiratori diphtheria case requir antitoxin phylogenom analys show evid import local transmiss toxigen strain respiratori skin lesion sampl given number case n larg genet divers accumul one centr increas awar chang public health measur requir prevent control diphtheria outbreak
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D004165;D003353
|
T047;T007
|
36,330,821
|
mcr colistin resist gene share escherichia coli cohabit dog human lisbon portug backgroundth emerg colistin resist one health antimicrobi resist challeng worldwid close contact companion anim human creat opportun transmiss dissemin colistin resist bacteriaaimto detect potenti anim reservoir colistin resist escherichia coli investig possibl share bacteria dog cat cohabit human communiti lisbon portugalmethodsa prospect longitudin studi perform faecal sampl dog cat either healthi diagnos skin soft tissu urinari tract infect cohabit human screen presenc colistin resist e coli isol test broth microdilut colistin antimicrobi colistin resist isol screen resist gene includ plasmid mediat colistin resist gene mcr mcr type multilocus sequenc type genet related anim human isol analys whole genom sequencingresultscolistin resist e coli strain harbour mcr gene recov faecal sampl companion anim human differ control infect group detect indistinguish multidrug resist e coli st strain harbour mcr gene found human dog two householdsconclusionsth identif ident e coli strain contain plasmid mediat mcr gene companion anim human daili close contact concern result demonstr import anim human unit possibl dissemin clinic import resist gene communiti set
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D004927;D029968
|
T047;T116
|
36,330,820
|
omicron ba variant effici neutralis follow ba ba breakthrough infect vaccin individu israel june septemb evalu neutralis antibodi titr wild type wt sar cov four omicron variant ba ba ba ba fulli vaccin three dose comirnati vaccin healthcar worker hcw israel breakthrough baba infect omicron breakthrough infect vaccin individu result increas neutralis antibodi wt omicron variant compar vaccin uninfect hcw hcw recov ba ba infect show similar neutralis antibodi level ba
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D000086402;D000086382
|
T005;T067;T047
|
36,330,819
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autochthon dengu mainland franc geograph extens incid increas franc face unusu situat dengu transmiss autochthon case spread nine transmiss event octob exceed number case observ entir period six event occur depart never experienc autochthon dengu transmiss provid updat dengu surveil data mainland franc multipl transmiss event call continu adapt prepared respons arbovirus relat risk
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D003715;D000330
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T047;T204
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36,330,784
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electron surveil patient safeti event use natur languag process describ approach surveil report safeti event captur hospit data includ free text clinic note hypothes patient safeti event document clinic note access sourc b larg scale abstract event data clinic note feasibl
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D009323;D061214
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T058;T066
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36,330,767
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sex relat short term blood pressur variabl differ kidney transplant recipi kidney transplant recipi ktrs display higher cardiovascular morbid mortal general popul increas short term blood pressur variabl bpv associ higher risk advers cardiovascular outcom chronic kidney diseas ckd aim studi investig sex differ short term bpv ktrs
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D016030;D051436;D006973
|
T061;T047
|
36,330,742
|
two side coin associ suicid stigma suicid normalis evid suggest suicid stigma ie negat attitud toward person affect suicidesuicid suicid normalis ie liber attitud toward suicid associ increas suicid risk despit conceptu similar potenti interact suicid stigma suicid normalis usual investig separ use cross section data communiti sampl test associ suicid stigma suicid normalis well identifi respect determin consequ
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D057545;D013405
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T033
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36,330,684
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two trichinellosi outbreak serbia challeng diagnosi due potenti co infect toxocara spp serbia case small famili outbreak trichinellosi occur due consumpt untest infect meat domest pig rais slaughter backyard small individu farm aim studi present data regard patient involv two outbreak occur two neighbour district serbia close relat period time august sourc infect first outbreak undercook pork raw pork sausag caus second outbreak meat sampl sausag trichinella spp posit artifici digest aim obtain second opinion valid serolog find discov public health institut nis sampl sent nation refer laboratori trichinellosi inep serodiagnosi show person posit three negat anti trichinella antibodi patient fulfil trichinellosi case definit western blot analysi use epitop uniqu muscl larva stage trichinella genus confirm diagnosi trichinellosi five patient six patient also specif antibodi toxocara cani due fact endem foci serbia presenc trichinella spirali cani two infect could asymptomat consid trichinellosi case irrefut proven dilemma exist co infect cani remain open due lack clinic find
|
D014235;D060085;D014234;D017166
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T047;T204
|
36,330,612
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food thought oblig carnivor cat easier challeng dog feed appropri
|
D002335
|
T008
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36,330,611
|
felophil think felin research mani passion research want carri research benefit cat face multipl obstacl
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D014730
|
T091
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36,330,610
|
tread care pick right path protect felin welfar come issu neuter microchip cat either advantag canin counterpart set catch also risk follow dog peril path
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D002371;D004283
|
T047
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36,330,609
|
mysteri intrigu attract felin medicin come vet care cat often perceiv trickier patient dog say elli mardel time patienc cat offer vet chanc practis interest medicin
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D018634;D002371;D004283
|
T047;T097
|
36,330,608
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rais bar cat friend care decad publish first felin friend handl guidelin intern cat care intern societi felin medicin pois launch new guidanc help everi veterinari profession think cat
|
D000827;D002371
|
T053;T052;T047
|
36,330,577
|
emerg radic nephrectomi polytrauma patient renal trauma present trauma case common caus conserv treatment perform report case renal trauma due metal sick requir surgic manag consid rare clinic case urgent surgic manag usual type trauma addit exampl quick decis make sinc patient life depend
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D007680;D009104
|
T191;T037
|
36,330,576
|
retroperiton laparoscop resolut posa abscess case report review literatur psoa abscess rare patholog entiti retroperitonescopi unusu therapeut modal resolut
|
D016659;D010535
|
T060;T047;T061
|
36,330,575
|
microbladd due granulomat cystiti secondari bcg treatment intraves immunotherapi bacillus calmett guerin bcg consid standard treatment non muscl invas bladder cancer high risk recurr progress
|
D002295;D001749;D003556
|
T047;T191
|
36,330,574
|
donat featur relat complic donat circulatori death kidney transplant analysi risk factor complic circulatori death kidney transplant complic donat circulatori death dcd kidney transplant kt bare describ urolog complic caus unknown aim studi describ surgic urolog complic analyz donat featur could involv
|
D016030;D009927;D008210
|
T061;T073;T055;T033;T058;T047
|
36,330,573
|
microrna p biomark earli detect urem vascular calcif among patient end stage renal diseas vascular calcif vc serious patholog manifest vascular termin import patholog basi cardiovascular diseas patient end stage renal diseas esrd studi explor clinic valu serum microrna p mir p vc patient esrd studi design
|
D035683;D007676;D061205
|
T123;T047;T114
|
36,330,572
|
prognost valu neutrophillymphocyt ratio squamous cell carcinoma peni determin predict role neutrophillymphocyt ratio nlr prognosi surviv patient squamous cell carcinoma peni
|
D002294;D010412
|
T191
|
36,330,571
|
role acid urin detrusor pressur patient overact bladder urodynam evalu evalu relationship urin ph valu urodynam paramet patient overact bladder
|
D014563;D053201
|
T047;T042
|
36,330,570
|
analysi predict capac clinic variabl indic perform void urosonographi studi vesicoureter reflux children void urosonographi vus dynam imag techniqu evalu lower urinari tract introduc sonograph contrast bladder prefer use diagnosi vesicoureter reflux vur goal describ clinic indic perform vus vur diagnosi analys diagnost reliabl
|
D014718
|
T047
|
36,330,569
|
role f cholin petct initi stage high risk prostat cancer comparison convent imag techniqu assess diagnost accuraci f cholin petct initi stage high risk prostat cancer pc compar convent imag techniqu assess chang therapeut attitud deriv result
|
D002794;D011471
|
T123;T121;T191;T109
|
36,330,568
|
applic platelet rich plasma urolog platelet rich plasma product obtain vein whole blood sampl high concentr growth factor report benefici tissu regener last year sever assay pretend demonstr efficaci platelet rich plasma mani disciplin includ urolog publish
|
D014572;D053657;D014570
|
T047;T091;T031
|
36,330,554
|
fall risk manag use clinic decis support rural nurs led primari care practic lead caus injuri among older adult unit state unintent fall american geriatr societybritish geriatr societi promot fall risk manag primari care howev challeng low resourc set
|
D020000;D064694
|
T058;T170;T091
|
36,330,553
|
optim product placement nurs practition physician assist outpati primari care site increas imper organiz leader continu assess nurs practition nps physician assist pas product turnov vacanc optim feasibl impact strateg placement monitor increas patient access improv wait time afford increas revenu
|
D010823;D009722
|
T097
|
36,330,551
|
first year experi transit regist nurs nurs practition transit advanc practic novic nurs practition need take new role learn new practic area develop new skill process requir break old practic work habit face new challeng
|
D009722
|
T097
|
36,330,550
|
telemedicin practic adult patient atrial fibril atrial fibril cardiac rhythm disord associ embol stroke risk decreas function capac worsen qualiti life increas patient access atrial fibril specialist via telemedicin potenti improv patient outcom
|
D001281;D017216;D009722;D020521
|
T047;T046;T058;T097
|
36,330,549
|
mitochondri disord understand mitochondri dna point mutat delet syndrom mitochondri disord aris dna mutat either mitochondri dna mtdna nuclear dna genom articl focus mtdna base pair mutat associ neuropathi ataxia retin pigmentosa leigh syndrom larg scale mtdna delet associ kearn sayr syndrom diseas sequela manag strategi review along implic nurs practition primari specialti care
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D028361;D007625
|
T047
|
36,330,548
|
make differ serv public offic need nurs polit nurs trust profess unit state nurs innat desir care other make differ peopl live nurs high educ rigor program teach physic scienc also account respons duti similar elect offici account duti repres constitu keep best interest forefront agenda characterist nurs includ higher educ integr respons compass one element rest build solid foundat leadership nurs natur leader govern need nurs get involv provid leadership benefit communiti includ local level polit decis affect us person one respons nurs take activ role polit polici develop nurs group extraordinari individu well suit lead elect offic influenc polici extern shape practic well patient
|
D006291;D011057
|
T078;T090;T055;T089;T068;T057
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36,330,531
|
hiv specif cd trm like cell tonsil express exhaust signatur absenc natur hiv control lymphoid tissu import hiv reservoir site persist face antiretrovir therapi natur immun target reservoir har antivir activ local tissu resid memori trm cd cell great interest limit data exist trm like cell within lymph node peopl live hiv plwh studi tonsil cd cell obtain plwh uninfect control south africa show cell preferenti locat outsid germin center gcs main reservoir site hiv display low cytolyt transcript trm like profil distinct blood cd cell plwh cd trm like cell expand adopt cytolyt activ exhaust phenotyp revers antiretrovir therapi art phenotyp enhanc hiv specif cd cell tonsil compar match blood suggest higher antigen burden tonsil singl cell transcript clonotyp resolut show hiv specif cd cell tonsil express heterogen signatur cell activ clonal expans exhaust ex vivo interest signatur absent natur hiv control express lower pd cxcr level reduc transcript evid cell activ exhaust cytolyt activ data provid import insight lymphoid tissu deriv hiv specif cd trm like phenotyp set hiv remiss highlight potenti immunotherapi target hiv reservoir
|
D018414;D015658
|
T047;T025
|
36,330,530
|
solubl mediat function epiderm immun neuro unit skin skin largest environment expos barrier organ capabl integr various signal effect defens respons function signific interact among epidermi immun nervous system regul maintain skin barrier function becom recogn relat skin pathophysiolog review focus newli describ pathway involv solubl mediat mediat crosstalk compart dysregul connect lead chronic inflammatori diseas andor patholog condit associ chronic pain itch
|
D004817;D012867
|
T022;T024
|
36,330,529
|
lactat tumor microenviron key obstacl nk cell base immunotherapi recent find new role lactat chang understand end product glycolysi ferment consid wast product well accept lactat act signal molecul fuel sourc cancer cell glucos restrict environ moreov lactat lactat dehydrogenas marker poor prognosi mani cancer regul mani function immun cell presenc lactat tumor microenviron tme lead polar immunosuppress phenotyp dendrit cell impair cytotox abil cell nk cell lactat major obstacl immun cell effector function efficaci cell base immunotherapi emerg evid suggest lactat tme might novel therapeut target enhanc immunotherapeut potenti cell base therapi review describ current understand role lactat tumor biolog includ detriment effect cell base immunotherapi cancer also highlight role lactat tme must consid produc cell therapi design adopt transfer describ target modul lactat tme might boost immun cell function posit impact cellular immunotherapi focus nk cell
|
D059016;D009369
|
T070;T191
|
36,330,527
|
dietari aflatoxin b attenu immun function immun organ grass carp ctenopharyngodon idella modul nf b tor signal pathway aflatoxin b afb kind common mycotoxin food feedstuff aquafe suscept contamin afb teleost fish spleen head kidney key immun organ moreov fish skin critic mucos barrier system howev littl studi effect dietari afb immun respons immun organ fish studi aim explor impact oral afb immun compet mechan skin spleen head kidney grass carp work indic dietari afb reduc antibacteri compound immunoglobulin content decreas transcript level antimicrobi peptid grass carp immun organ addit dietari afb increas transcript level pro inflammatori cytokin reduc transcript level anti inflammatori cytokin grass carp immun organ might regul nf b tor signal respect meanwhil evalu content afb grass carp diet exceed gkg diet accord level acid phosphatas lysozym summari dietari afb impair immun respons grass carp skin spleen head kidney
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D002347;D005393;D016905
|
T047;T013
|
36,330,526
|
level solubl complement regul predict sever covid symptom sar cov virus continu caus signific morbid mortal worldwid covid one major challeng patient manag broad rang symptom observ major individu experi relat mild diseas signific minor patient requir hospitalis covid still prove fatal remain desper need better understand drive sever diseas term under biolog also potenti predict diagnosi patient like requir intervent thus enabl better outcom patient healthcar system sever line evid point dysregul complement cascad major factor sever covid outcom underpin mechanist known focuss role solubl complement regul complement factor h fh splice variant factor h like fhl five factor h relat protein fhr use target mass spectrometri approach quantifi protein cohort plasma sampl control sar cov patient taken diagnosi analysi reveal signific elev fhr protein fh patient sever diseas particular fhr fhr fhr fold p lt fhr fold p lt furthermor subset sar cov patient also analys time cours sampl taken approxim day post diagnosi see complement regul level drop individu asymptomat mild diseas regul remain high sever outcom elev fhr baselin level group data support hypothesi elev circul level fhr famili protein could predict diseas sever covid patient durat elev lack immun activ resolut may part respons drive poor outcom covid
|
D017242;D000086382
|
T129;T047;T116;T067
|
36,330,525
|
arginas target peptid vaccin patient metastat solid tumor phase trial arginas produc cell inhibit cell mediat anti tumor respons reduc l arginin level tumor microenviron cell facilit elimin arginas express cell could potenti restor l arginin level improv anti tumor respons activ arginas specif cell may convert immunosuppress tumor microenviron induc strengthen local th inflamm current clinic studi examin safeti immunogen arginas base peptid vaccin
|
D019496;D009369
|
T129;T121;T191;T116
|
36,330,524
|
myokin myostatin novel predictor one year radiograph progress patient rheumatoid arthriti prospect cohort studi associ rheumatoid arthriti ra reduc skelet muscl studi first report myopenia independ predict one year radiograph progress ra myokin myostatin negat regul skelet muscl mass promot osteoclast differenti howev report relationship ra patient first explor relationship serum myostatin diseas characterist well aggrav joint destruct one year follow
|
D055435;D001172
|
T123;T047;T116
|
36,330,523
|
prolong hematolog toxic patient receiv bcmacd car cell therapi relaps refractori multipl myeloma although chimer antigen receptor car cell therapi indic effect treat relaps refractori multipl myeloma rr mm sever hematolog toxic ht remain intract issu studi enrol patient rr mm follow combin infus anti cd anti bcma car cell result show rate sever cytopenia high includ sever neutropenia sever anemia sever thrombocytopenia moreov incid prolong ht pht day post infus includ sever neutropenia sever anemia sever thrombocytopenia patient pht poorer median progress free surviv pfs overal surviv os patient without pht p p furthermor cox regress analys show pht independ risk factor pfs os univari analys show ifn ci p sever ht lymphodeplet chemotherapi ci p independ risk factor pht conclus result indic pht associ poor outcom follow car cell therapi mm patient earli detect manag pht would benefici prevent life threaten complic improv surviv patient car cell therapi
|
D000740;D009101;D009503;D000076962;D013921
|
T129;T116;T192;T191;T047
|
36,330,522
|
photoactiv adenylyl cyclas attenu sepsi induc cardiomyopathi suppress macrophag mediat inflamm sepsi induc myocardiopathi character innat immun cell infiltr proinflammatori cytokin releas may lead perfus failur even life threaten cardiogen shock macrophag mediat inflamm shown contribut sepsi induc myocardiopathi current studi introduc two photoactiv adenylyl cyclas pac beggiatoa sp pac bpac beggiatoa sp pac bipac macrophag transfect detect effect light induc regul macrophag pro inflammatori respons lps induc sepsi induc myocardiopathi method uncov blue light induc bpac bipac activ consider inhibit product pro inflammatori cytokin il tnf mrna protein level assembl gelma macrophag led system consist gelma type light crosslink hydrogel gene modul macrophag wireless led devic allow light regul cardiac inflamm situ murin model lps induc sepsi result show signific inhibit leukocyt infiltr especi macrophag neutrophil suppress pro inflammatori cytokin releas allevi sepsi induc cardiac dysfunct thus studi may repres emerg mean treat sepsi induc myocardiopathi cardiovascular diseas photo activ regul macrophag function
|
D053524;D018805;D009202
|
T047;T007;T046
|
36,330,521
|
transcriptom analysi identifi lgp mda mediat signal activ follow spring viremia carp virus infect common carp cyprinus carpio l common carp cyprinus carpio l import farm speci worldwid mucos associ lymphoid tissu play essenti role fight pathogen infect spring viremia carp virus svcv pose serious threat common carp aquacultur industri understand molecular mechan drive mucos immun respons svcv infect critic studi mucos tissu gill foregut hindgut collect normal infect fish transcriptom analysi total clean read obtain approxim success map common carp genom differenti express gene deg identifi gill foregut hindgut respect quantit polymeras chain reaction assay indic deg express foregut follow svcv infect consist transcriptom result among two key gene retino acid induc gene rig like receptor famili melanoma differenti associ gene mda laboratori genet physiolog lgp ie ccmda cclgp underw analysi overexpress ccmda cclgp increas phosphoryl tank bind kinas interferon regulatori factor express interferon ifn myxovirus resist mx viperin interferon stimul gene isg inhibit svcv replic epithelioma papulosum cyprini cell furthermor cclgp signific upregul ccmda induc ifn mrna express activ ifn promot final confoc microscopi coimmunoprecipit experi reveal cclgp coloc interact ccmda via c termin regulatori domain studi provid essenti gene resourc understand fish immun respons svcv infect shed light potenti role fish lgp mda regul
|
D002347;D005393;D018353
|
T047;T013
|
36,330,520
|
cell receptor signal schimk immuno osseous dysplasia smarcal independ schimk immuno osseous dysplasia siod caus mutat smarcal ultra rare diseas character specif facial featur skelet dysplasia steroid resist nephrot syndrom often lead kidney failur requir transplant cellular cell defici lymphopenia infect frequent report whether due cell intrins defect cell receptor tcr signal associ smarcal defici cell extrins effect impair prolifer hematopoiet precursor cell specif immunosuppress renal transplant remain unknown explor effect smarcal defici cell receptor signal primari immort cell year old siod patient immunosuppress treatment compar healthi donor immort cell recapitul smarcal defici patient judg impair respons gamma irradi result indic tcr mediat signal normal siod deriv immort cell strong impair primari cell patient although rescu tcr independ stimuli pma ionomycin suggest siod associ cell signal intrins defect rather result impair prolifer hematopoiet precursor cell specif immunosuppress lack earli thymic emigr patient may support former hypothesi
|
D007153;D009404
|
T047
|
36,330,519
|
evolv understand antibodi depend enhanc ade sar cov sinc immun system intern environ vivo larg complex interpret observ immun effect perspect singl immun cell antibodi seem littl feebl mani studi shown specif antibodi former virus reduc abil neutral new mutant strain howev comprehens clear view whether antibodi depend enhanc ade review latest relev studi hope explain ade sar cov infect sometim observ patient
|
D019067;D000086382
|
T049;T047;T067
|
36,330,518
|
stat signal modul immun respons induc antigen target convent type dendrit cell dec receptor convent dendrit cell cdc group antigen present cell special prime cell respons mice splenic cdc divid convent type dc cdc convent type cdc cdc special prime th cd cell respons cdc main associ induct follicular helper cell respons support germin center format howev mechan control function cdc cdc fulli understood especi signal pathway modul abil promot differ cd cell respons target model antigen cdc cdc dec dcir receptor respect studi role stat signal pathway abil cell prime cd cell result show absenc stat signal pathway antigen target cdc induc similar frequenc tfh cell stat defici mice compar fulli compet mice hand th th like tfh cell respons signific reduc stat defici mice antigen target cdc via dec receptor summari result indic stat signal control abil cdc promot tfh cell respons antigen target via dcir receptor modul function cdc promot th th like tfh cell respons antigen target via dec receptor
|
D003713;D015398
|
T025;T044;T043
|
36,330,517
|
bet drive convers human type innat lymphoid cell function nk cell type innat lymphoid cell ilc character rort express produc il upon activ ilc play role mainten barrier integr intestin inflammatori condit ilc composit mucos tissu alter due high degre plastic extens demonstr murin human ilc convert ilc mediat appropri immun respons howev plastic human ilc nk cell less well document bet eom key transcript factor nk cell differenti investig whether ectop bet eom express convert human ilc nk cell ilc ectop bet eom express downregul rort express bet overexpress ilc addit upregul eom express high e ctopic bet express ilc result transdifferenti toward cd nk cell wherea ectop eom overexpress result dedifferenti ilc cd cd low cell ineffect nk cell generat dedifferenti ilc bet eom overexpress cultur upregul nk cell receptor perforin granzym b final il secret complet block transdifferenti ilc bet eom ectop express wherea bet overexpress increas ifn secret cytotox altogeth find demonstr human ilc convert function nk cell wherein bet eom main driver
|
D007113;D057132
|
T032;T116;T192
|
36,330,516
|
lactat driven macrophag polar inflammatori microenviron allevi intestin inflamm lactat long consid intermedi product glucos metabol howev recent year accumul evid reveal lactat uniqu biolog activ previous studi lactat signal shown inhibit inflamm furthermor vitro experi shown lactat promot transform pro inflammatori macrophag anti inflammatori macrophag howev vivo studi shown whether lactat allevi inflamm
|
D016328;D003092
|
T129;T047;T116
|
36,330,515
|
neonat sepsi transient immunodefici potenti novel immunoglobulin therapi neonat especi preterm neonat highest risk sepsi age group transient immatur neonat immun system import risk factor neonat suffer hypogammaglobulinemia iga igm transfer placenta igg transfer placenta late gestat addit neutrophil number complement function also decreas mini review focus strategi improv neonat host defens clinic preclin studi attempt boost neonat immun lower incid sepsi improv outcom recent advanc develop monoclon antibodi show promis result preclin studi yet test clinic trial strategi increas complement activ seem effici vitro potenti disadvantag hyperinflamm held back clinic develop increas neutrophil number test extens clinic trial fail show improv mortal futur research focus clinic applic promis new prevent strategi neonat sepsi
|
D000071074;D018805;D007153
|
T047;T046
|
36,330,514
|
pitfal complement analysi systemat literatur review assess complement activ complement system essenti compon innat defens play vital role pathogenesi mani diseas assess complement activ critic monitor diseas progress respons therapi complement analysi requir accur standard sampl assay procedur proven challeng
|
D003182;D003167
|
T129;T123;T116;T044
|
36,330,513
|
character sialyl relat long noncod rnas develop novel signatur predict prognosi immun landscap chemotherapi respons colorect cancer aberr sialyl play key biolog role tumorigenesi metastasi includ tumor cell surviv invas immun evas angiogenesi resist therapi propos possibl cancer biomark potenti therapeut target tumor nevertheless prognost signific biolog featur sialyl relat long noncod rnas lncrnas colorect cancer crc remain unclear studi aim develop novel sialyl relat lncrna signatur accur evalu prognosi patient crc explor potenti molecular mechan sialyl relat lncrnas identifi sialyl relat lncrnas use pearson correl analysi cancer genom atlas tcga dataset univari stepwis multivari cox analysi use establish signatur base seven sialyl relat lncrnas tcga dataset risk model valid gene express omnibus dataset kaplan meier curv analysi reveal crc patient low risk subgroup better surviv outcom high risk subgroup train set test set overal set multivari analysi demonstr sialyl relat lncrna signatur independ prognost factor overal surviv progress free surviv diseas specif surviv predict sialyl lncrna signatur base nomogram exhibit robust prognost perform furthermor enrich analysi show cancer hallmark oncogen signal enrich high risk group inflammatori respons immun relat pathway enrich low risk group comprehens analysi suggest low risk patient higher activ immun respons pathway greater immun cell infiltr higher express immun stimul addit determin sialyl level normal colon cell crc cell line flow cytometri combin immunofluoresc verifi express level seven lncrnas use real time quantit polymeras chain reaction final combin drug sensit analysi use genom drug sensit cancer cancer therapeut respons portal profil relat inhibit simultan mixtur indic sialyl relat lncrna signatur could serv potenti predictor chemosensit collect first sialyl lncrna base signatur predict prognosi immun landscap chemotherapeut respons crc may provid vital guidanc facilit risk stratif optim individu therapi crc patient
|
D062085;D015179
|
T123;T191;T114
|
36,330,511
|
optim ventil strategi surgeri patient obes perspect lung protect network meta analysi new ventil mode propos support periop treatment patient obes lack consensus regard optim strategi therefor network meta analysi updat ventil strategi conduct determin optim mode mechan ventil protect ventil strategi decreas pulmonari atelectasi caus inflamm
|
D008168;D001261
|
T023;T046;T047
|
36,330,510
|
epsti immun biomark predict prognosi patient stage iii colon cancer poor prognosi heterogen stage iii colon cancer cc suggest need prognost biomark tumor microenviron tme play crucial role tumor progress aim explor novel immun infiltr associ molecul serv potenti prognost therapeut target
|
D009364;D003110
|
T191
|
36,330,509
|
hookworm infect associ vagin type type immun signatur increas hpv load helminth infect driven chang immun femal reproduct tract frt immun axi current understudi major implic control frt infect address human hookworm infect associ vagin immun profil risk human papillomavirus hpv infect stool blood cervic swab vagin flush collect women central region togo screen hookworm ancylostoma duodenal high carcinogen risk hpv type via kato katz pcr respect cytokin chemokin immunoglobulin level analys cervicovagin lavag plasma sampl pronounc mix type type immun respons detect vagin fluid women hookworm infect immun signatur notabl featur hookworm hpv co infect women moreov hookworm infect posit associ increas risk load hpv infect find highlight helminth infect signific risk factor acquir sexual transmit viral infect potenti rais risk subsequ patholog
|
D030361;D006725;D060737;D006373
|
T047
|
36,330,507
|
diverg outcom anti pd l treatment coupl host intrins differ tcr repertoir distinct cell activ state respond versus non respond tumor differenti respons immun checkpoint inhibitor ici may attribut tumor intrins factor environment cue howev mechan fulli explain variabl ici respons differ individu investig potenti contribut immunolog heterogen focus differ cell receptor tcr repertoir ici respons defin previous reveal addit factor under heterogen respons ici employ squamous cell carcinoma scc mous model tumor bear recipi unambigu diverg respond r non respond nr upon anti pd l treatment treatment efficaci absolut requir cd cell correl posit effector function cd tumor infiltr lymphocyt til show tcr repertoir exhibit similar magnitud clonal expans r vs nr cd til howev top expand tcr clonotyp appear mutual exclus r nr cd til also occur recipi specif manner demonstr preferenti expans distinct tcr clonotyp scc tumor unexpect r vs nr cd til reach activ cluster exhibit substanti global differ transcriptom link singl cell transcriptom data uniqu tcr clonotyp cd til harbor top tcr clonotyp found occupi distinct activ cluster upregul gene favor anti tumor immun differ extent r vs nr conclud stochast differ cd til tcr repertoir distinct activ state top tcr clonotyp may contribut differenti anti pd l respons studi suggest host intrins immunolog heterogen may offer new explan differenti ici respons differ individu could impact strategi person cancer immunotherapi
|
D016246;D002294
|
T191;T025
|
36,330,506
|
explor immunomodulatori role virtual memori cd cell role ifn gamma tumor growth control virtual memori cd cell tvm describ cell memori like phenotyp without previous antigen ag exposur tvm cell abil respond better innat stimuli rather tcr engag produc larg amount interferon gamma ifn stimul interleukin il plus il result phenotyp similar tvm cell erron includ central memori cell subset mani year howev discrimin via cdd receptor regul convent memori cell tmem effector cell teff specif cognat ag recognit tcr work show system express il plus il induc alter normal tvm vs tmemteff distribut secondari lymphoid organ preferenti enrich tvm cell melanoma b pancreat ductal adenocarcinoma kpc tumor model use kpc bear ot mous model observ signific increas cd cell infiltr tumor islet il il stimul lower averag speed compar control mice find indic stronger interact cell tumor cell cytokin stimul result correl signific reduct tumor size tumor model il il treat ot mice compar control ot mice interest absenc ifn complet abolish high antitumor capac induc il il express indic import role cytokin earli tumor growth control thus studi provid signific new inform indic import role tvm cell immun respons cancer
|
D007371;D009369
|
T129;T121;T191;T116
|
36,330,505
|
complex set intern repeat sptransform protein sequenc result multipl limit altern align sptransform sptrf gene famili encod set protein function sea urchin immun system gene sequenc seri intern repeat mosaic pattern characterist famili mosaic pattern necessit insert larg gap made align deduc protein sequenc comput difficult manual align report previous manual align time consum evalu newli avail sptrf sequenc comput approach evalu sequenc report previous furthermor two differ manual align sptrf sequenc feasibl multipl intern repeat known whether addit altern align identifi use differ approach bioinformat program prank use design align sequenc larg gap indel result prank show align intern repeat similar done manual suggest multipl feasibl align region guidanc base analysi align identifi region excel region fail align suggest comput approach limit align sptrf sequenc includ multipl repeat requir insert gap furthermor unlik altern align full length sptrf sequenc identifi
|
D012984;D019295
|
T090;T170;T091;T073
|
36,330,461
|
evalu moral distress intens relationship qualiti work life among nurs work oncolog ward shiraz southwest iran moral distress defin incid prevent appropri function individu spite requir knowledg nurs common expos moral distress profession role influenc qualiti work life present studi aim assess relationship moral distress intens work life qualiti amongst nurs
|
D001291;D009726
|
T097;T041
|
36,330,460
|
immun system act orthodont tooth movement cellular molecular mechan orthodont tooth movement otm tissu remodel process base orthodont forc load compress periodont tissu complic asept inflammatori cascad consid initi factor alveolar bone remodel sinc skelet immun system share wide varieti molecul osteoimmunolog general accept interdisciplinari field investig interact unsurpris otm consid good mirror osteoimmunolog sinc involv immun reaction bone remold fact besid bone remodel otm involv cementum resorpt soft tissu remodel orthodont pain relaps correl immun cell andor immunolog activ substanc aim paper review interact immun system orthodont tooth movement help gain insight mechan otm search novel method short treatment period control complic
|
D014087;D010010
|
T061;T025
|
36,330,459
|
taurin upregul gene attenu cerebr angiogenesi follow ischem stroke rat angiogenesi one therapeut target cerebr infarct long noncod rnas lncrnas regul patholog process angiogenesi follow ischem stroke taurin upregul gene tug lncrna correl ischem stroke intend determin effect tug angiogenesi follow ischem stroke
|
D035683;D000083242;D062085
|
T123;T047;T114
|
36,330,458
|
assess statin treatment pulmonari alveolar proteinosi without hypercholesterolemia month prospect longitudin observ studi pulmonari alveolar proteinosi pap rare disord character accumul excess surfact lipid protein alveolar macrophag alveoli oral statin therapi report novel therapi pap hypercholesterolemia aim evalu safeti efficaci oral statin therapi pap without hypercholesterolemia
|
D011649;D019161;D006937
|
T121;T047;T109
|
36,330,457
|
identif valid novel necroptosi relat long noncod rna prognost signatur lung adenocarcinoma sever cancer includ lung adenocarcinoma luad caus gene relat necroptosi howev still unknown necroptosi relat long noncod rnas lncrnas may involv luad order predict prognosi luad patient person immunotherapi studi set construct necroptosi relat lncrna prognost signatur nlps
|
D062085;D008175;D000230
|
T123;T191;T114
|
36,330,456
|
advanc diagnosi monitor progress oral cancer saliva updat earli detect cancer particular oral cancer prioriti object studi recent year saliva propos easi obtain mean provid necessari inform diagnos malign lesion oral caviti sinc obtain easili complet noninvas number molecul known biomark may involv malign transform oral lesion differ natur involv protein proteom metabolit metabolom even certain gene structur chang alter tissu investig order establish valid paramet earli diagnosi oral cancer addit develop new analyt assay method reduc cost obtain better result term sensit specif key point recent research field even though numer biomark result show high sensit specif still need studi larger sampl analyt method constitut real advanc time cost although salivari biomark promis new diagnost tool oral cancer moment replac biopsi gold standard
|
D012463;D009062
|
T191;T031
|
36,330,455
|
applic rad ultrasound lexicon base logist regress analysi model diagnosi solid compon contain ovarian malign use logist regress model evalu valu ultrasound characterist ovarian adnex report data system ultrasound lexicon determin ovarian solid compon contain mass benignancymalign
|
D000291;D010051
|
T047;T191
|
36,330,454
|
soy isoflavon bone health focus ranklrankopg pathway bone remodel via resorpt format two phenomena continu occur bone turnov ranklrankopg pathway one sever mechan affect bone turnov ranklopg ratio substanti role bone resorpt imbal format resorpt relat increas ranklopg balanc opg member system bind rankl suppress rank rankl interact subsequ inhibit osteoclastogenesi serum level rankl opg bone microenviron vital osteoclast format rankranklopg system play role pathogenesi bone disord system consid new treatment target bone disord soy isoflavon affect rankranklopg system numer mechan soy isoflavon decreas rankl level increas opg level therefor isoflavon improv bone metabol decreas bone resorpt soy isoflavon decreas serum marker bone resorpt improv bone metabol howev avail data promis result sever studi report chang rankl opg level isoflavon supplement regard current evid insuffici conclus approv efficaci isoflavon ranklrankopg research includ anim human studi need confirm effect soy isoflavon ranklrankopg pathway studi review avail evid determin role isoflavon bone hemostasi rankranklopg pathway identif effect isoflavon ranklrankopg pathway direct futur studi lead develop effect treatment strategi bone disord
|
D001862;D001847;D007529
|
T121;T047;T109;T042
|
36,330,453
|
regulatori effect fyn trophoblast cell behavior function fyn proven involv various cell behavior pathophysiolog process howev express role fyn trophoblast remain unclear aim evalu particip fyn trophoblast behavior function relat mechan briefli explor fyn express htr svneo jeg jar cell line evalu immunofluoresc quantit real time pcr western blot fyn express human hydatidiform mole also determin immunohistochemistri western blot explor effect fyn htr svneo jeg cell transfect fyn shrna overexpress plasmid treat fyn activ inhibitor su erk inhibitor u migrat prolifer apoptosi trophoblast cell assess use transwel assay flow cytometri cell count kit assay respect product primari inflammatori cytokin hla g activ matrix metallopeptidas mmp phosphoryl erk stat evalu elisa western blot gelatin zymographi result show fyn express trophoblast cell main cytoplasm membran fyn express activ level increas order htr svneo jar jeg overexpress fyn promot prolifer migrat trophoblast cell inhibit apoptosi opposit effect observ fyn knockdown inhibit fyn regul inflammatori cytokin product trophoblast cell promot tgf il secret inhibit ifn tnf secret moreov hla g express jeg posit regul fyn fyn also facilit express activ mmp activ erk stat besid confirm fyn regul trophoblast cell activ erk signal pathway use u studi first detect express fyn trophoblast cell fyn play pivot role trophoblast cell behavior function erk one target mmp stat may also involv regulatori mechan
|
D014327;D020778
|
T018;T126;T116
|
36,330,452
|
assess mechan action fructus ligustri lucidi cuscuta semen prostat cancer treatment use network pharmacolog molecular dock explor mechan action fructus ligustri lucidi cuscuta semen treatment prostat cancer use network pharmacolog molecular dock
|
D031659;D004365;D011471
|
T123;T121;T191;T002
|
36,330,380
|
comprehens analysi function characterist differenti express n methyladenosin methyl modif whole transcriptom rheumatoid arthriti n methyladenosin modif preval chemic modif eukaryot mrna associ develop various immun diseas howev role methyl rheumatoid arthriti ra develop unclear preliminarili explor role methyl relat mrnas ra clinic applic discoveri methyl modifi gene studi may provid fresh perspect develop drug ra treatment high throughput sequenc combin methyl rna immunoprecipit merip seq rna sequenc use assess whole transcriptom modif synovium patient ra relationship modifi target gene ra inflamm macrophag determin express modifi signific transcript enrich inflammatori signal pathway assess anim experi differenti express gene correl macrophag activ involv immun respons vascular endothelium mapk signal pathway pik akt signal pathway inflammatori process furthermor combin analysi seq rna seq reveal gene signific chang modif mrna express select top candid mrnas upregul downregul simultan express phosphatas tensin homolog delet chromosom ten pten mrna protein ra patient lower healthi control hc shc bind protein shcbp neurexophilin nxph mrna express increas ra patient express macrophag increas ra patient ra marker rheumatoid factor rf peptid contain citrullin ccp anim experi show express synovi mapk pik akt protein ra model increas pten p pten protein express decreas pik akt pten p pten correl ra joint inflamm studi reveal uniqu pattern differenti methyl modif ra conclud modif relat occurr ra synovi inflamm
|
D059467;D001172
|
T081;T047;T086
|
36,330,360
|
secur medic data model use integr transform paillier klein algorithm encrypt techniqu eleph herd optim healthcar applic healthcar industri concern frequent appropri focus save someon life access interfac comput system store sensit data medic record crucial take account medic inform secret protect law privaci restrict access e health secur holist notion encompass avail medic data integr confidenti ensur data access unauthor peopl allow doctor offer proper treatment patient data need secur server hold medic data work add new featur ensur storag access safeti itpklein eho integr transform paillier klein algorithm use eho eleph herd optim provid lightweight featur key space affect lightweight encrypt techniqu general eho eleph herd optim optim key space adjust iter round main goal encrypt eeg electroencephalograph signal healthcar send end user use propos itpklein eho approach suggest techniqu util matlab test various eeg data set implement simul propos irpklein eho techniqu evalu exist techniqu term mses psnrs ssim prds encryptiondecrypt time
|
D016494;D004606
|
T078;T080;T170;T015;T097;T057
|
36,330,359
|
biomechan effect disc height compon lumbar column axial load finit element studi intervertebr disc fibrocartilag structur play role buffer compress appli vertebr bodi even permit limit movement accord sever previous studi degen chang intervertebr disc could acceler factor age femal sex obes smoke degen chang progress disc height could reduc due dehydr nucleus pulposus studi aim quantit analyz pressur structur spine receiv accord chang disc height predict physiolog effect disc height spine analyz biomechan effect spinal structur disc height decreas use finit element method investig lumbar spine use fe model degre distribut von mise stress accord disc height chang measur appli load four differ motion lumbar spine height chang divid anterior posterior part disc analysi perform follow four motion flexion extens later bend axial rotat except circumst stress appli structur general increas disc height decreas phenomenon pronounc direct forc concentr coincid portion disc height decreas studi demonstr degre stress appli spinal structur general increas disc height decreas increas stress promin part disc height decreas part moment addit appli coincid disc height reduct could acceler degen chang spine therefor elimin control risk factor caus disc height reduct may benefici spinal health
|
D007403
|
T023
|
36,330,351
|
effect extract fraction date pit plasma constitu reproduct hormon testicular histolog male mice pit date phoenix dactylifera l numer nutrit benefit could wide rang applic studi aim examin effect administ three extract powder date pit basic physiolog paramet plasma constitu reproduct hormon testicular histolog cd male mice three group receiv dose mgkgday lyophil extract nonpolar fraction polar fraction date pit oral gavag consecut day control one group administ mlkg concentr distil water three differ extract signific increas plasma testosteron level show signific effect estradiol lutein hormon level except estradiol reduct polar extract group measur physiolog biochem paramet testicular histolog also demonstr signific differ control mice mice treat three extract except reduct plasma urea extract total protein nonpolar extract therefor date pit extract may potenti use safe effect dietari supplement howev investig need
|
D010936;D065749
|
T123;T121;T168;T002
|
36,330,350
|
cellular anti inflammatori antioxid activ bamboo sasa albomarginata leaf extract constitu coumar acid methyl ester hot water extract sasa albomarginata kumazasa leav commerci avail use dietari supplement skincar cream extract possess anti inflammatori activ mous atop dermat model elucid mechan vivo activ studi cellular anti inflammatori antioxid activ extract constitu
|
D031787;D007938
|
T191;T002
|
36,330,204
|
downregul mcfl promot ferroptosi hepatocellular carcinoma cell pikmtor pathway rhoarac depend manner level mcfl detect pcr western blot assay effect mcfl ferroptosi confirm mtt coloni format assay brdu vivo anim experi content iron gsh ros mda under mechan explor pcr western blot affin precipit assay find demonstr mcfl remark upregul hcc tissu sorafenib induc level mcfl suggest mcfl might function sorafenib resist hcc analysi show downregul mcfl enhanc hcc cell death induc sorafenib ferroptosi inhibitor revers process subsequ experi show downregul mcfl elev content iron ros mda indic ferroptosi final mechan analysi show mcfl regul pikakt pathway rhoarac depend manner
|
D006528;D000079403;D008113
|
T191;T043
|
36,330,203
|
hfpef atrial fibril enigmat interplay dysmetabol biomark vascular endotheli dysfunct heart failur preserv eject fraction hfpef complex pathophysiolog encompass system proinflammatori state dysregul level cardiometabol oxid stress biomark preval hfpef atrial fibril af continu rise especi elder aim studi explor differ biomark level vascular function elder patient hfpef without af assess interconnect clinic relev biomark cardiac vascular function
|
D006333;D001281
|
T047;T046
|
36,330,130
|
meta analysi public health risk lead accumul wastewat irrig soil crop nexus lead pb differ sourc accumul irrig water irrig soil differ part plant report show contradictori find high variabl lead accumul associ public health risk hypothes lead accumul irrig water soil edibl plant high enough public health risk use standard procedur meta analysi studi qualifi studi includ meta analysi concentr countri strong author key word co occurr relationship mean concentr pb irrig wastewat rang mgl mgl wastewat valu beyond limit irrig water standard studi also show concentr pb irrig soil vari signific minimum mgl ethiopia maximum mgl iran p base effect size analysi weight studi rang indic studi contribut overal effect bare differ heterogen test statist also indic consider variabl studi p valu subgroup analysi show larg studi heterogen group tau total crop studi leafi non leafi veget popular crop includ spinach cabbag lettuc frequent studi crop crop pb level crop produc use untreat wastewat beyond limit edibl studi pollut load index pli soil accumul factor saf much higher indic buildup pb concentr wastewat irrig soil plant concentr factor pcf calcul show high pb accumul potenti edibl part crop health risk index hri calcul show studi crop india iraq morocco egypt much higher one indic high health risk consumpt
|
D019216;D012989
|
T131;T196
|
36,330,129
|
impact climat chang wood woodwork cryptostroma cortical sooti bark diseas risk factor tree expos employe climat chang promot increas fungal infect mapl tree cryptostroma cortical causat agent sooti bark diseas host c cortical mapl sinc earli fungus appear frequent european forest due drought hot summer recent year infest c cortical discolor wood make unus process lead consider econom damag timber industri therefor occurr spread sooti bark diseas rais serious problem addit forestri econom problem conidiospor c cortical also caus health problem expos wood worker trigger hypersensit pneumon hp sinc spore deposit entir area bark infect tree spread process expos worker must take special precaut protect exposur occup diseas nevertheless suspect follow exposur c cortical valid diagnost requir confirm possibl hp deriv appropri therapi exposur reduct avoid diagnosi hp base sever criteria one detect specif igg patient serum potenti trigger antigen case c cortical antigen produc diagnost tool measur c cortical specif igg commerci avail far spore myceli materi sequenc strain c cortical prepar analyz biochem character extract spore myceli antigen biotinyl coupl streptavidin immunocap valid diagnost test tool first step measur concentr c cortical specif igg sera healthi non expos healthi expos subject establish cut valu suitabl particip recruit individu exposur c cortical symptom experienc work infect mapl tree record use questionnair final diagnost tool serolog test suspect case hp c cortical creat evalu follow articl provid recommend treatment dispos infect damag wood occup health protect procedur second diagnosi hp induc exposur c cortical occup diseas describ includ verif newli develop serolog test tool antigen c cortical
|
D057231;D009784;D014934;D016273
|
T047;T070;T167;T037
|
36,330,128
|
mediat path physic multimorbid vulner health relat poverti rural age famili ningxia china cross section survey vulner health relat poverti predict probabl famili fall poverti due health risk impact studi measur vulner health relat poverti examin mediat path physic multimorbid vulner health relat poverti rural age famili ningxia china
|
D000076322;D011203
|
T078;T098;T102;T064
|
36,330,127
|
realli experi perceiv discrimin ident develop among asian indian adolesc asian indian first south asian immigr unit state late current largest ethnic group south asian live unit state despit literatur perceiv ethnic racial discrimin experi among group relat understudi document experi asian indian either recent immigr india born rais america pose import question experi perceiv discrimin among asian indian live america particular among younger popul continu develop racial ethnic ident current studi util phenomenolog methodolog explor experi nine asian indian american adolesc age year data collect via semi structur interview assess particip experi ethnic racial discrimin ident develop themat analysi use identifi theme subthem among particip respons asian indian adolesc live unit state report experienc discrimin young age also evid asian indian youth experi signific challeng develop sens ethnic racial ident live within unit state find document racial ethnic discrimin asian indian adolesc live unit state may experi young age import discrimin experi occur asian indian adolesc develop racial ethnic ident studi provid insight futur research necessari fulli understand experi asian indian adolesc
|
D000091563;D063505
|
T054;T041
|
36,330,126
|
tobacco industri messag around harm narrat frame pmi bat press releas annual report influenc public percept key way transnat corpor tncs maintain market domin polit power transnat tobacco compani ttcs long histori leverag narrat serv commerci ambit global reach compani narrat highlight challeng combat public health problem caus tobacco corpor power ttcs care curat narrat play import role set govern dynam local nation transnat level qualit work explor compar languag use british american tobacco bat philip morri intern pmi around harm harm reduct term use refer newer nicotin tobacco product includ electron cigarett heat tobacco product systemat examin frame use two ttcs compani report publish qualit code carri four coder accord protocol develop specif work first identifi presenc pre select keyword assign chunk text contain key word one associ frame drawn boydstun polici frame codebook qualit code identifi common frame boydstun codebook themat analysi highlight three overarch theme common frame assign capac resourc health safeti econom frame overarch theme individu normal regul theme captur bat pmi use particular frame downplay role ttcs perpetu popul individu level harm relat tobacco use seek normal role public discuss health polici cast instrument redress tobacco relat inequ shift respons continu tobacco product use onto individu consum tactic problemat effect imparti develop implement local nation intern tobacco control agenda
|
D019460;D066300;D062789
|
T092;T073;T131;T109
|
36,330,125
|
resourc mobil tetanus vaccin vietnam uptak demand willing pay among women reproduct age tetanus vaccin coverag vietnam declin recent year due rapid popul growth rate shrink budget ineffici resourc mobil strategi studi examin uptak demand willing pay wtp tetanus vaccin vietnames women reproduct age well determin associ factor assess feasibl long term tetanus vaccin resourc mobil scheme
|
D013742
|
T047
|
36,330,124
|
effect covid pandem antibiot consumpt systemat review compar data coronavirus diseas covid pandem influenc antibiot consumpt long period variabl trend among studi conduct systemat review explor compar effect pandem overal individu antibiot consumpt
|
D000086382;D000073602
|
T047;T058;T067
|
36,330,122
|
planetari sleep medicin studi sleep individu popul planetari level circadian rhythm seri endogen autonom oscil generat molecular circadian clock coordin synchron intern time extern environ h daili cycl also shorter longer h besid daili rhythm exist well biolog rhythm differ time scale includ season annual rhythm circadian biolog rhythm deepli permeat human life level span molecular subcellular cellular tissu organism level environment exposur behavior lifestyl human immers call circadian landscap circadian rhythm high pervas ubiquit affect everi ecosystem planet plant insect fish bird mammal anim anthropogen behavior produc cascad compound seri effect includ detriment impact human health howev effect climat chang sleep relat overlook present narrat review paper want offer way readr think sleep medicin planetari health perspect climat chang complex seri either direct indirect mechan includ pollut poor air qualiti induc oxygen satur variabilityhypoxia ii chang light condit increas nighttim iii fluctuat temperatur warmer valu heat due extrem weather iv psycholog distress impos disast like flood wildfir drought hurrican infecti outbreak emerg reemerg pathogen may contribut induc mismatch intern time extern environ disrupt sleep caus poor sleep quantiti qualiti sleep disord insomnia sleep relat breath issu among other climat chang generat relev cost impact vulner popul underserv area thus widen alreadi exist global geograph age sex gender relat inequ
|
D016083;D007319
|
T184;T047;T169;T048
|
36,330,121
|
awar knowledg attitud toward influenza vaccin sever popul group china cross section studi aim comprehens analyz awar knowledg attitud toward influenza vaccin factor associ vaccin accept among young middl age general popul healthcar worker health relat administr china factor influenc promot influenza vaccin also evalu among healthcar worker administr
|
D007252;D007251
|
T129;T047;T121;T109
|
36,330,120
|
trend cancer incid among chines older adult log linear regress age period cohort analysi studi correspond strategi control cancer older adult age china comprehens assess diseas burden requir therefor introduc cancer epidemiolog characterist older adult china recent year period
|
D001943
|
T191
|
36,330,119
|
human mobil variat respons restrict polici covid pandem analysi virus watch communiti cohort england uk sinc outbreak covid public health social measur contain transmiss eg social distanc lockdown dramat chang peopl live rural urban area global facilit futur manag pandem import understand differ socio demograph group adher demand studi aim evalu influenc restrict polici human mobil variat associ socio demograph group england uk
|
D000086382
|
T047;T067
|
36,330,118
|
topolog base evalu resili urban road network epidem spread implic covid respons road closur effect measur reduc mobil prevent spread epidem sever public health crise instanc peak wave global covid pandem mani countri implement road closur polici traffic calm strategi uk howev still clear road closur use respons differ mode epidem spread affect resili perform larg scale road network term effici overal access paper propos simul base approach theoret investig two type spread mechan evalu effect static dynam respons scenario includ sporad epidem spread base network topolog trajectori base spread caus superspread megac result show road network demonstr compar wors resili behavior trajectori base spread mode road densiti central order well network region geograph characterist substanti alter level impact introduc heterogen recoveri process resili lost static recoveri dynam recoveri scenario respect demonstr necess dynam respons import make systemat strateg recoveri plan polici manageri implic also discuss paper provid new insight better manag resili urban road network public health crise post covid era
|
D000086382
|
T047;T067
|
36,330,117
|
impact covid live mental health children adolesc student mental health integr part fight diseas health evolv concern spread covid covid pandem unfold physic distanc social restrict introduc found great impact student live mental health adolesc mental health focus prevent earli detect therapeut innov servic develop circumst servic provid expand telemedicin digit servic may help provid futur mental health servic young peopl particular student studi collect analyz data student impact new onlin learn techniqu collect analyz challeng issu face colleg student covid pandem questionnair base extend european student union survey target higher educ student concern student life look like pandem includ teach learn social contact habitsroutin well cope situat emot financi case univers distanc learn educ unit higher educ covid pandem process articl highlight impact covid student age time schedul onlin learn reflect studi environ sleep habit routin outcom found student general requir greater self disciplin motiv complet onlin class also reflect pandem advers affect student mental health lead increas preval major depress disord mdd general anxieti disord gad may signific impact mental health issu frustrat stress sad signific lead cooper various local author privat sector
|
D000086382;D003865
|
T047;T067;T048
|
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