Javtor/biomedical-topic-categorization-validation

PMID int64 35.7M 36.4M	Title/Abstract stringlengths 22 8.78k	MeshTerms stringlengths 7 101	SemanticTypes stringlengths 4 64
36,329,513	efficaci safeti treamid rehabilit patient covid pneumonia phase random doubl blind placebo control trial mani patient recov covid still suffer pulmonari dysfunct persist even month infect therefor treatment prevent irrevers impair lung function need treamid bisamid deriv dicarboxyl acid bdda shown anti inflammatori antifibrot effect anim model pulmonari fibrosi studi design assess safeti toler efficaci treamid rehabilit patient covid pneumonia aim establish whether treamid could effect amelior post covid sequela	D000086382	T047;T067
36,329,512	blood base lipidom signatur sever obstruct sleep apnoea alzheim diseas obstruct sleep apnoea osa frequent form sleep disord breath patient alzheim diseas ad avail evid demonstr condit independ associ alter lipid metabol howev unknown whether express lipid differ ad patient without sever osa context examin plasma lipidom patient suspect osa aim identifi potenti diagnost biomark provid insight pathophysiolog mechan under diseas	D000544;D020181	T047;T048
36,329,510	segreg stabilis plasmid improv product commod chemic glucos limit continu ferment product chemic via bio base rout held back limit easi use stabilis system wide rang plasmid stabilis mechan found literatur howev mechan effect genet stabil host strain still revert non product variant poor understood singl cell level phenomenon generat difficulti product scale bioreactor differ popul product non product cell aris understand prevent non product strain aris vital understand strain behaviour singl cell level persist gene locat plasmid vector depend numer factor broad separ structur stabil segreg stabil structur stabil refer capabl cell resist genet mutat bring loss gene function product pathway segreg stabil refer capabl cell correct distribut plasmid daughter cell maintain copi number lack segreg stabil rapid generat plasmid free variant replic compromis product	D004926;D005947	T121;T123;T007;T109
36,329,508	isol identif broad spectrum high effici phage vbsalpldw therapeut applic chicken salmonella infect livestock poultri caus salmonellosi main treat use antibiot howev misus use antibiot often trigger emerg multi drug resist salmonella strain current salmonella phage safe effect salmonella serv best drug choic studi involv salmonella bacteriophag separ purifi sewag fece broiler farm phage vbsalpldw select base phage host rang test phage vbsalpldw character doubl layer plate method transmiss electron microscopi furthermor clinic therapeut effect phage vbsalpldw verifi use pathogen salmonella enteritidi spf chicken model	D001435;D012480;D012478	T005;T037;T047
36,329,506	integr rehabilit servic primari health care polici option iran provid rehabilit servic primari health care phc associ numer health social econom benefit therefor low middl incom countri iran benefit advantag integr rehabilit servic phc conduct qualit studi determin polici solut could facilit integr rehabilit servic iran phc network	D011320;D003695	T058;T093
36,329,505	character diazotroph root endophyt chines silvergrass miscanthus sinensi phytoremedi potenti cost effect way remedi high contamin mine tail site howev nutrient limit especi defici nitrogen n hinder growth plant impair phytoremedi mine tail nevertheless pioneer plant success colon mine tail exhibit potenti tail phytoremedi diazotroph especi diazotroph endophyt promot growth host plant test mine tail habitat combin field sampl dna stabl isotop probe sip analysi pot experi	D060026;D006109	T004;T002
36,329,504	singl cell rna sequenc reveal rebalanc immunolog respons patient periodont non surgic periodont therapi periodont major inflammatori diseas oral mucosa limit oral caviti also system consequ although import chronic periodont emphas system immun respons induc periodont therapeut effect remain elus report transcriptom peripher blood mononuclear cell pbmcs patient periodont	D052243;D055113	T125;T047;T116
36,329,503	pfo morpholog evalu c tcd c tte rls grade purpos studi observ morpholog characterist patent foramen oval pfo transesophag echocardiographi tee analyz correl right left shunt rls contrast transthorac echocardiographi c tte contrast transcrani doppler ultrasonographi c tcd	D054092	T019
36,329,500	associ habitat autogeni genet moroccan culex pipien popul mosquito culex pipien complex found across globe focus mani research studi among temper speci c pipien sensu stricto ss two form usual describ molestus pipien two form indistinguish term morpholog show behavior physiolog differ may consequ associ epidemiolog two form well defin northern part speci distribut autogeni strict associ molestus form howev whether two remain distinct show characterist differ behavior less clear north africa southern edg rang	D003465	T204
36,329,499	observ studi investig relationship plasma glucosylsphingosin lyso gb concentr treatment outcom patient gaucher diseas japan gaucher diseas gd autosom recess diseas caus gba mutat result glucosylceramid accumul macrophag gd character hepatosplenomegali anemia thrombocytopenia bone complic neurolog complic glucosylsphingosin lyso gb deacyl form glucosylceramid identifi promis biomark diagnosi treatment respons gd aim studi examin relationship plasma lyso gb therapeut goal gd improv hepatomegali splenomegali anemia thrombocytopenia bone pain bone crisi well diseas type gba mutat type japanes patient gd receiv velagluceras alfa enzym replac therapi ert furthermor studi compar plasma lyso gb concentr observ japanes patient includ studi observ previous non japanes clinic studi	D005776;D013921	T047
36,329,498	oral viscer iatrogen kaposi sarcoma follow treatment acut lymphoblast leukemia case report review literatur hard report case children present kaposi sarcoma second malign follow treatment acut lymphoblast leukemia outsid transplant set	D012514;D016609;D054198;D010157	T191
36,329,497	carbon dot deriv folic acid attenu osteoarthr protect chondrocyt nf bmapk pathway reprogram macrophag osteoarthr oa common joint disord worldwid caus great health econom burden howev remain unmet goal develop effect therapeut method prevent delay oa chondrocyt major cell involv oa progress may serv promis therapeut target	D019902;D010003	T047;T025
36,329,496	plasma adiponectin level predict cognit declin cortic thin mild cognit impair beta amyloid patholog blood adiponectin leptin adipokin emerg potenti biomark predict alzheim diseas ad owe strong connect obes although obes affect relat beta amyloid aggreg cognit declin longitudin interact effect adipokin cognit brain structur human remain unexplor henc investig whether plasma level adiponectin leptin associ futur cognit declin cortic thin across condit individu mild cognit impair mci	D000544;D060825	T047;T048
36,329,495	evid pituitari gland connect type diabet mellitus schizophrenia base larg scale tran ethnic genet analys previous studi european eur sampl obtain inconsist result regard genet correl type diabet mellitus tdm schizophrenia scz larg scale tran ethnic genet analysi may provid addit evid enhanc power	D012559;D003924	T047;T048
36,329,494	risk factor nineti day readmiss follow cervic surgeri meta analysi import evalu index cervic surgeri nineti day readmiss gradual valu studi collect latest publish relev studi analyz risk factor nineti day readmiss cervic surgeri continu improv postop rehabilit plan studi focus two research hotspot rate nineti day readmiss cervic surgeri risk factor affect nineti day readmiss	D008171;D006331;D006973	T047
36,329,492	neuron matter neuromodul electromagnet stimul must consid neuron dynam ident neuromodul electromagnet stimul wide use control abnorm neural activ proven valuabl altern pharmacolog tool treatment mani neurolog diseas tremend effort focus design stimul apparatus ie electrod magnet coil deliv electr current neural tissu optim stimul paramet less attent given complic dynam properti neuron context depend impact stimul effect review focus neuron factor influenc outcom electromagnet stimul neuromodul evid multipl level tissu cellular singl ion channel review properti neural element dynam chang play signific role outcom electromagnet stimul angl understand yield comprehens perspect neural activ electr neuromodul provid insight design develop novel stimul technolog	D050781;D009422	T062;T047;T061
36,329,491	visual clonal expans massiv deplet cell carri bovin leukemia virus blv integr site cours diseas progress blv natur infect cow case report bovin leukemia virus blv infect cattl integr host dna provirus induc malign b cell lymphoma previous studi address impact provir integr blv blv induc leukemogenesi howev studi monitor sequenti chang integr site natur infect blv individu progress premalign stage termin diseas collect blood sampl singl natur infect holstein cow three diseas progress stage stage polyclon stage stage ii polyclon toward oligoclon stage stage iii oligoclon stage success visual kinet clonal expans cell carri blv integr site use blv provir dna captur sequenc method although integr site detect stage ii site experienc massiv deplet stage iii site locat within intron refseq gene intergen region repetit sequenc respect stage iii cattl lymphoma two integr site generat de novo intergen region chr intron chek gene chr signific increas result first demonstr clonal expans massiv deplet cell carri blv integr site natur infect cow	D001909;D016583	T005;T191
36,329,489	public awar knowledg sepsi cross section survey adult canada sepsi life threaten complic bodi respons infect financi medic psycholog cost sepsi individu healthcar system high sepsi case origin communiti make public awar sepsi essenti earli diagnosi treatment comprehens examin adult sepsi knowledg canada	D000086382;D018805	T047;T046;T067
36,329,488	age relat radiograph paramet differ degen lumbar spinal stenosi patient healthi peopl correl analysi identifi age relat radiograph risk factor degen lumbar spinal stenosi dlss analyz correl among	D013130;D055959	T047;T020;T190
36,329,487	appar mineralocorticoid excess comprehens overview molecular genet appar mineralocorticoid excess autosom recess form monogen diseas character juvenil resist low renin hypertens mark hypokalem alkalosi low aldosteron level high ratio cortisol cortison metabolit caus defect hsdb gene encod enzym hydroxysteroid dehydrogenas type hsd primarili involv peripher convers cortisol cortison date deleteri hsdb mutat identifi worldwid multipl molecular mechan function lower hsd activ includ damag protein stabil lower affin substrat cofactor disrupt dimer interfac genet polymorph environment factor well epigenet modif may also offer implicit explan molecular pathogenesi ame precis diagnosi depend genet test allow earli specif manag avoid morbid mortal target organ damag review provid insight molecular genet classic non classic appar mineralocorticoid excess aim offer comprehens overview monogen diseas	D003348;D006973	T125;T121;T047;T109
36,329,486	cross site collabor infect prevent control research room improv year compar studi five european countri spread sar cov multidrug resist organ healthcar associ pathogen repres supra region challeng infect prevent control ipc specialist everi european countri tackl problem cross site research collabor ipc specialist import studi assess extent qualiti nation research collabor ipc depart univers hospit locat austria england franc germani netherland identifi network gap provid potenti solut	D003428;D000086382	T047;T067
36,329,485	research implement interact social account studi util guidanc conduct process evalu complex intervent recent year research evalu made effort identifi use appropri innov research design account complex studi social account relationship research implement activ impact studi receiv littl attent paper reflect manag relationship research implement use unit kingdom medic research council mrc guidanc process evalu complex intervent	D012941;D012108	T078;T097;T054
36,329,483	comprehens genotyp phenotyp evalu eight chines proband waardenburg syndrom waardenburg syndrom ws common form syndrom deaf phenotyp genet heterogen chines popul studi aim clarifi clinic characterist genet caus eight chines ws famili includ three famili five sporad case genotyp phenotyp relationship also investig	D014849	T047
36,329,482	earli intub clinic outcom patient sever covid systemat review meta analysi evid regard time applic mechan ventil among patient sever coronavirus diseas covid insuffici systemat review meta analysi aim evalu effect earli intub compar late intub patient sever critic covid	D000086382	T047;T067
36,329,481	lower gestat age associ lower cortic volum cognit educ perform adolesc gestat age ga associ later cognit behavior howev unclear specif cognit domain brain structur develop vari stepwis chang gestat durat	D007234;D001921	T033;T023;T100
36,329,478	primari squamous cell carcinoma thyroid gland case report popul base studi primari squamous cell carcinoma thyroid gland pscct high aggress malign tumor associ poor prognosi due rare case knowledg gap featur pscct limit understand treatment molecular biolog tumor genom work relev perspect work need done	D013964;D002294	T191
36,329,477	high preval canin heartworm dirofilaria immiti pet dog south texa usa evid aed aegypti mosquito contribut transmiss canin heartworm dirofilaria immiti filarioid nematod dog carnivor widespread usa world differ mosquito speci serv intermedi host immiti contribut transmiss vari accord factor like host feed pattern geograph locat climat condit yellow fever mosquito aed aegypti compet vector immiti often dismiss vector veterinari relev given anthropophil feed behavior evalu preval immiti pet dog along usa mexico border assess whether ae aegypti area natur infect heartworm potenti act vector	D004183;D000330;D004184;D004283	T047;T204
36,329,476	earli life antibiot exposur increas risk childhood overweight obes relat dysbiosi gut microbiota birth cohort studi earli life antibiot exposur associ develop later obes disrupt gut microbiota anim model howev relat epidemiolog evid still conflict	D000069196;D063766	T033;T047;T007;T001
36,329,474	assess genet burden famili hypercholesterolemia larg middl eastern biobank genet architectur under famili hypercholesterolemia fh middl eastern arab yet fulli describ approach assess popul wide biobank import public health plan person medicin	D000071449;D006938	T047;T126;T116
36,329,473	learn base control approach servic robot cloth manipul dress assist comprehens review servic robot defin reprogramm sensor base mechatron devic perform use servic autonom semi autonom way human activ everyday environ number elder peopl grow servic robot oper complex task like dress task disabl peopl demand increas consequ grow interest studi dress task put shirt hat shoe servic robot robot manipul develop accomplish task use sever control approach robot use kind applic usual bimanu manipul ie baxter robot singl manipul ie ur robot arm usual use recogn cloth fold put item arm head person	D012371;D006233	T090;T101
36,329,472	associ chiropract integr ontario communiti health centr continu prescript opioid use chronic non cancer spinal pain sequenti explanatori mix method studi emerg evid suggest access chiropract care may reduc likelihood initi opioid prescript spinal pain howev impact chiropract care patient alreadi prescrib opioid uncertain undertook sequenti explanatori mix method studi evalu associ initi chiropract care continu opioid use among adult patient attend ontario communiti health centr chc receiv opioid therapi chronic non cancer spinal pain	D059350;D002684;D009293	T184;T047;T091;T048
36,329,471	take cat mous game next level differ perspect introduct german new psychoact substanc act counteract spread new psychoact substanc nps prevent emerg novel substanc specif design respons legal control individu substanc new law introduc germani new psychoact substanc act npsg npsg combin generic approach waiver crimin liabil acquisit possess nps person use novelti german narcot law present studi aim explor impact introduct npsg three differ perspect nps user staff addict care facil member law enforc author better understand dynam surround chang legisl contribut bodi intern experi deal nps	D011619;D007880	T089;T121
36,329,470	explor risk factor cervic lymph node metastasi papillari thyroid microcarcinoma construct novel popul base predict model machin learn high effect tool model construct aim establish machin learn base predict model predict cervic lymph node metastasi lnm papillari thyroid microcarcinoma ptmc	D001185;D013964	T090;T191;T073;T066
36,329,469	landscap hervrna transcrib human endogen retrovirus across human bodi site human endogen retrovirus herv remnant ancient retrovirus account human genom lost transcript abil physiolog condit howev mount evid show sever express herv exert biolog function systemat character physiolog express herv examin whether may give insight molecular fundament human develop diseas	D020077	T005
36,329,468	systemat evalu pre eclampsia drug dietari supplement biolog pipelin use target product profil acceler innov mother aim project establish databas candid medicin research develop r five pregnanc relat condit includ pre eclampsia parallel publish target product profil tpps describ optim characterist medicin use preventingtr pre eclampsia studi object use systemat doubl screen extract identifi candid medicin investig pre eclampsia preventiontreat rank potenti base tpps	D011225;D001688;D008687	T121;T123;T046;T109
36,329,467	limb acceler sleep relat measur strength sensat spastic among individu spinal cord injuri evalu relationship measur neuromuscular impair limb acceler la collect sleep among individu chronic spinal cord injuri sci provid evid construct concurr valid la clinic meaning measur	D009128;D013119	T184;T037;T048
36,329,466	attitud polish physician nurs pharmacist toward ethic legal aspect conscienc claus healthcar profession right invok conscienc claus recognis fundament human right continu provok heat debat polish societi although public discours fill ethic legal consider conscienc claus much less known attitud healthcar profession regard matter aim studi therefor describ attitud polish physician nurs pharmacist toward ethic legal aspect conscienc claus	D003242;D010820	T097;T041
36,329,465	dual target nanozym tumor activat photo chemodynam theranost tumor phototheranost hold great promis account high spatiotempor resolut tumor specif noninvas howev physic limit light penetr alway properti convent phototherm convers agent usual caus difficulti accur diagnosi complet elimin tumor meanwhil nanozym mediat fenton reaction well util tumor microenviron tme generat hydroxyl radic chemodynam therapi cdt limit concentr h tme deliveri effici nanozym overcom problem dual target nanozym ftrnps develop tumor specif situ theranost base upon assembl ultrasmal fe nanoparticl tetrameth ylbenzidin tmb rgd peptid ftrnps h treatment exhibit superior phototherm stabil high phototherm convers effici ftrnps show extraordinari accumul retent tumor site biologicalphys dual target fold higher without activ target cascad dual respons tme nanozym mediat fenton reaction tmb oxid improv accuraci photoacoust imag phototherm therapi ptt tumor inhibit rate photo chemodynam therapi fold higher ptt cdt thus combin cdt ptt construct turn nanoplatform great signific overcom respect limit consid optim one perform new nanoplatform expect provid advanc theranost strategi futur treatment cancer	D009369;D053758	T191;T073
36,329,464	defect microtubul cytoskelet organ noa human test import actin microtubul mt cytoskeleton testi function rodent known extent role etiolog azoospermia human remain unexplor examin mt cytoskeleton defect noa non obstruct azoospermia test versus normal human test base histopatholog immunofluoresc scrna seq transcriptom profil testi biopsi sampl n normal men versus n sertoli cell sco n meiotic arrest noa patient use histopatholog analysi analysi also use examin mt organ across seminifer epithelium investig like involv microtubul associ protein map scrna seq transcriptom profil dataset test sco patient versus normal men public domain gene express omnibus geo sampl gsm identifi analyz examin relev gene regul mt dynam noa test sco patient display notabl defect mt organ across epithelium extens truncat mis align appear collaps structur near base tubul chang contrast mts test normal men scrna seq analys reveal consider loss spermatogenesi capac sco test noa patient versus normal men array gene support mt dynam display consider chang express spatial distribut summari defect mt cytoskeleton note test noa sco patient possibl mediat defect spatial express andor distribut map chang turn may imped spermatogenesi sco test noa patient	D053713	T047
36,329,463	later approach aesthet option radic resect bscc assess surgic oncolog function aesthet outcom purpos studi introduc modifi later approach combin radic resect buccal squamous cell carcinoma bscc evalu surgic oncolog function aesthet outcom comparison convent lower lip split approach	D004955;D002294	T191;T091
36,329,462	inferior sublux humer head osteosynthesi greater tuberos fractur inferior sublux humer head frequent observ immedi surgeri proxim humerus fractur howev incid risk factor inferior sublux osteosynthesi isol greater tuberos fractur remain unsolv addit postop cours inferior sublux elucid purpos present studi identifi predictor occurr postop inferior sublux multivari analysi investig postop shift inferior sublux effect surgic outcom	D012784;D004204	T037
36,329,461	implement threefold intervent improv palliat care person experienc homeless process evalu use aim framework palliat care provis person experienc homeless often poor threefold consult servic intervent expect increas knowledg palliat care multidisciplinari collabor improv palliat care popul intervent compris consult social servic profession palliat care specialist vice versa multidisciplinari meet profession train educ profession aim evalu implement process barrier facilit servic implement within social servic healthcar organ three dutch region	D000086382;D006703;D064946	T098;T058;T091;T067;T033;T047;T095
36,329,460	sepax cell process devic studi assess reproduc concentr thaw hematopoiet progenitor cell autolog hematopoiet progenitor cell hpc transplant current standard care fraction patient newli diagnos myeloma relaps refractori lymphoma high dose chemotherapi cryopreserv hpc either infus direct bedsid thaw wash concentr infus previous report compar washingconcentr hpc post thaw vs infus without manipul term hematopoiet engraft yet settl prior favor cell debri dmso remov almost two decad autom critic step washingconcentr cell feasibl part continu process verif aim evalu reproduc procedur assess intra batch inter batch variabl upon concentr thaw hpc product use sepax cell separ system	D006412;D018380	T061;T025
36,329,459	shoulder work relat musculoskelet disord relat factor worker industri china cross section studi chang modern industri product practic easili lead shoulder work relat musculoskelet disord wmsd current report shoulder wmsd limit industri less well studi sampl size usual small studi aim describ preval sever shoulder wmsd larg sampl chines worker industri analyz possibl correl sociodemograph work relat variabl compar differ industri	D009784;D009140	T047
36,329,458	associ angiotensin convert enzym insertiondelet ace id gene polymorph suscept prostat cancer updat meta analysi meta analysi aim explor associ angiotensin convert enzym ace insertiondelet id gene polymorph suscept prostat cancer pca	D020022;D011471	T032;T191
36,329,457	risk indic dental cari gingiv among year old children nigeria household base survey littl known factor associ cari experi gingiv among year old children nigeria aim studi determin preval prevent oral health behavior associ cari gingiv among year old children nigeria	D003731;D005891	T033;T047
36,329,456	triglycerid glucos index risk heart failur evid two larg cohort mendelian random analysi relationship triglycerid glucos tyg index emerg marker insulin resist risk incid heart failur hf unclear studi thus aim investig relationship	D005947;D006333	T123;T121;T109;T047;T046
36,329,455	evolv trust respons covid pandem among migrant norway covid pandem profound consequ world popul particular vulner group like migrant face barrier healthcar access trust author crucial crisi manag strategi implement govern howev trust author link trust area life evolv crisi studi explor migrant trust norwegian govern respons covid pandem	D000086382;D058873;D014171;D035502	T054;T047;T098;T067
36,329,454	malaria diagnost treatment practic febril children year two general hospit karamoja high transmiss set uganda malaria one lead caus morbid mortal among children year age uganda although karamoja sub region highest preval malaria one highest case fatal rate children year inform malaria case manag sub region scarc studi evalu malaria diagnost treatment practic well factor associ inappropri care children year age present fever two public hospit within sub region	D000962;D008288	T121;T047
36,329,453	mediat effect vascular risk factor under link gestat diabet cardiovascular diseas women gestat diabet gdm elev lifetim incid cardiovascular diseas cvd basi excess risk remain establish context hypothes chronic exposur advers cardiovascular risk factor may contribut elev risk cvd thus sought quantifi determin cvd risk women histori gdm perform mediat analys	D016640;D002318	T047
36,329,452	potenti montmorillonit modifi organosulfur surfact reduc aflatoxin b toxic rumin methanogenesi vitro montmorillonit clay modifi organosulfur surfact possess high cation exchang capac cec adsorpt capac unmodifi form um therefor may elev advers impact aflatoxin b afb rumin ferment methanogenesi chemic mechan modif use innov organ modifi nano montmorillonit mnm um modifi use sodium dodecyl sulfat sds ground obtain nanoscal particl size form dose respons effect mnm supplement basal diet contamin afb ppb evalu vitro use gas product gp system follow treatment test control basal diet without supplement um diet um supplement mg kg dri matter dm mnm diet low mg kg dm high dose mg kg dm	D016604;D012417	T131;T196;T023;T109
36,329,451	rethink rural use hospit referr region investig rural urban health outcom rural resid unit state face disproportion poorer health outcom compar urban resid studi aim establish continu rural urban measur hospit referr region hrrs us investig relationship proport rural popul serv hrr health outcom healthcar spend util access qualiti primari care	D012424;D006278	T064;T089;T098;T102
36,329,450	similar cost outcom differenti servic deliveri model hiv treatment uganda cost outcom studi estim perspect servic provid total annual cost per client antiretrovir therapi art total annual cost per client viral suppress defin year old enrol dsdm studi found retent care sampl whole viral suppress mean cost provid moh ngo implement per annum per client treat rang differ among model cost larg due client arv regimen proport client second line regimen servic deliveri cost exclud arv medicin laboratori test modest rang per client per year conclud differenti art servic deliveri uganda achiev excel treatment outcom cost similar standard care larg budgetari save might immedi realiz realloc save staff time could improv health system effici equival better outcom larg benefit client client centr differenti model would nevertheless add great societ valu	D015658;D019380	T121;T047
36,329,449	breakag risk differ sacroiliac screw unilater sacral fractur finit element analysi compar breakag risk lengthen sacroiliac screw ordinari sacroiliac screw treat unilater vertic sacral fractur provid refer clinic applic	D050723;D016103	T037
36,329,448	hif caspas express aggress papillari thyroid carcinoma tumor cell adapt hypoxia regul transcript factor involv regul metabol angiogenesi cell prolifer apoptosi hypox condit hypoxia induc factor hif consist hif hif subunit act key transcript factor mediat adapt cellular respons caspas key apoptosi relat proteas play role tumor growth develop studi shown caspas could regul hif patholog condit therefor hif caspas express may relat poor prognosi tumor studi analyz possibl relationship two signal factor correl clinic behavior ptc	D051795;D013964	T123;T191;T116
36,329,446	tripartit motif contain protein acceler influenza hn virus infect promot k link ubiquitin tbk avian influenza hn emerg threaten public health caus acut respiratori distress syndrom even death human popul howev under mechan hn virus caus human infect remain elus	D064766;D005585;D007251;D007370	T129;T121;T116;T005;T047
36,329,445	pregnanc sexual relat problem among women live street dire dawa citi eastern ethiopia qualit studi problem women youth live street global phenomenon creat countless problem live street unwant pregnanc sexual exploit prostitut frequent observ see women beg street major citi ethiopia one two babi side studi give depth understand distress high challeng problem among women street regard pregnanc relat problem	D012725;D012749	T055;T053;T032;T047
36,329,444	import earli diagnosi view newborn screen metachromat leukodystrophi result caregiv survey uk republ ireland metachromat leukodystrophi mld rare autosom recess lysosom storag disord caus defici enzym arylsulfatas arsa mld caus progress loss motor function sever declin cognit function lead prematur death earli diagnosi mld provid opportun begin treatment diseas progress caus sever disabl mld current includ newborn screen nbs ukthi studi consist onlin survey follow semi structur interview open mld patient caregiv age year aim studi understand import earli diagnosi establish view famili caregiv patient mld nbsa total patient took part survey repres famili two famili two children mld one famili three children mld follow survey six parent particip interview data show diagnost delay first symptom year median year n time deterior rapid especi earlier onset mld patient late infantil mld n wheelchair depend unabl speak tube fed diagnosi mld confirm patient earli juvenil mld n half use wheelchair time uncontrol cri difficulti speak time diagnosi high degre support express nbs among caregiv describ extrem import believ detect mld birth would chang child futur one parent express gratitud earli diagnosi result famili mld screen offer birth chang child futur absolut forev grate earli diagnosi thank older sister rapid rate deterior mld make essenti candid nbs particular first gene therapi libmeldi approv european medicin agenc libmeldi also recommend treatment option england wale nation institut health care excel nice made avail patient scotland via scottish medicin consortium ultra orphan pathway	D007966	T047
36,329,443	anxieti depress post pandem era concern viral mutat outbreak coronavirus pandem covid rage month put signific strain public health system around world despit fact pandem effect manag certain countri region outbreak viral mutat continu pose threat peopl live likelihood post pandem chang peopl psycholog situat warrant investig	D058873;D000086382	T047;T067
36,329,442	new proof evid cysteamin quantif therapeut drug monitor patient cystinosi date measur intracellular cystin use therapeut monitor patient affect cystinosi treatment cysteamin sinc method time sampl consum develop faster method quantifi cysteamin would extrem use order help clinician adjust dosag cysteamin defin better pharmacokinet profil drug aim studi develop liquid chromatographi tandem mass spectrometri method quantif cysteamin plasma sampl test applic plasma sampl deriv patient nephropath infantil cystinosi treatment cysteamin	D003554	T047
36,329,441	venturia inaequali effector repertoir domin expand famili predict structur similar unrel sequenc avirul protein plant pathogen fungi scab caus biotroph fungus venturia inaequali econom import diseas appl worldwid infect v inaequali occupi subcuticular environ secret virul factor term effector promot host colon consist plant pathogen fungi mani effector expect non enzymat protein recogn correspond host resist protein activ plant defenc thus act avirul determin develop durabl control strategi scab better understand role effector protein play promot subcuticular growth v inaequali well activ suppress circumv resist protein mediat defenc appl requir	D001203;D027845	T168;T004;T002
36,329,440	tailor optim fatti acid product oleagin yeast systemat explor physiolog fit use palm oil current need unsustain replac palm oil oil produc microb convers sustain feedstock promis altern howev major technic challeng must overcom enabl transit foremost among challeng stark increas lipid accumul product higher content specif fatti acid therefor need depth knowledg systemat explor oil product oleagin yeast studi cultiv cutaneotrichosporon oleaginosus yarrowia lipolytica various cn ratio temperatur defin medium glycerol carbon sourc urea nitrogen sourc ascertain synergist effect various cn ratio defin medium differ temperatur respons surfac methodolog rsm explor variat fatti acid composit princip compon analysi	D005227;D025062	T123;T168;T004;T109
36,329,439	pharmaci locat medic need region evid canada pharmacist canada assum increas import role provis primari care servic rais question access pharmaci servic among medic care need evid proxim resid ontario nova scotia communiti pharmaci littl evid rest canada thus measur avail pharmacist servic number communiti pharmaci hour oper provinci sub provinci level canada next measur associ indic medic need avail pharmacist servic across sub provinci unit	D010594;D003157;D010604	T091;T073;T093;T058;T057
36,329,438	postop pedicl screw posit dorsal instrument without intraop cone beam ct imag wors patient obes normal weight patient intraop cone beam ct cbct imag dorsal instrument facilit pedicl screw posit howev patient obes benefit may reduc due artifact affect imag qualiti purpos studi evalu whether intraop cbct lead improv postop screw posit compar convent fluoroscopi independ bodi weight	D065289;D013123;D025321	T061;T074
36,329,437	complet respons nivolumab kirsten rat sarcoma virus oncogen kras gc mutant metastat lung adenocarcinoma case report advent immunotherapi usher new era treatment non small cell lung carcinoma although immunotherapi associ improv clinic outcom studi report median overal surviv month progress free surviv month use nivolumab pretreat metastat non small cell lung cancer herein describ case advanc non small cell lung carcinoma shown except respons immunotherapi patient complet respons past year sinc commenc nivolumab	D002289;D008175;D000077192	T191
36,329,436	ferroptosi assassin tumor near million peopl got cancer near million peopl die cancer indic cancer remain great threat human health life new therapi still urgent demand develop novel cancer therapi name ferroptosi assassin tumor fast combin iron oxid nanoparticl cancer select knockdown seven key ferroptosi resist gene fpn lcn fth fsp gpx slca nrf found fast notabl anti tumor activ varieti cancer cell littl effect normal cell especi fast erad three differ type tumor leukemia colon cancer lung metastat melanoma cancer mice make mice surviv day without tumor relaps fast also signific inhibit prevent growth spontan breast cancer improv surviv mice fast show high pan anti tumor efficaci high cancer specif vivo safeti fast defin new form advanc nanomateri advanc combinatori nanomateri combin two kind nanomateri chemic nanomateri iron oxid nanoparticl biochem nanomateri adeno associ virus success turn general iron nanomateri unpreced assassin cancer	D000079403;D008175;D001943	T191;T043
36,329,435	comparison frailti patient nontubercul mycobacteri lung diseas bronchiectasi prospect cohort studi incid nontubercul mycobacteri lung diseas ntm ld peak middl old age group coincid senesc thus chronic infecti diseas acceler frailti worsen mental health elder studi aim compar preval physic psychiatr frailti patient ntm ld bronchiectasi	D001987;D000073496;D009165;D011014	T184;T050;T033;T047;T046
36,329,434	donor age effect vitro chondrogen osteogen differenti perform equin bone marrow adipos tissu deriv mesenchym stromal cell bone marrow bm adipos tissu deriv mesenchym stromal cell mscs shown potenti cell base therapi cartilag bone injuri use increas human veterinari practic facilit treatment orthoped condit howev human rodent studi document sharp declin chondrogen osteogen differenti potenti increas donor age may problemat import demograph older orthoped patient aim studi identifi effect donor age chondrogen osteogen differenti perform equin bm mscs vitro bm mscs dermal fibroblast biolog negat control harvest hors five differ age group n n newborn day yearl month adult year middl age year geriatr year chondrogen differenti perform assess quantit measur pellet size matrix proteoglycan level gene express articular cartilag biomark osteogen differenti perform assess quantit measur alkalin phosphatas activ calcium deposit gene express bone biomark	D010012;D059630	T025;T042
36,329,433	knowledg attitud practic univers student regard covid cross section studi vietnam cross section studi investig knowledg attitud practic kap vietnames univers student regard covid	D000086382	T047;T067
36,329,432	antibiofilm activ ultra small gold nanoclust fusobacterium nucleatum dental plaqu biofilm pathogen dental plaqu biofilm univers harm result oral infect system diseas mani convent therapeut method proven insuffici ineffect plaqu biofilm therefor new strategi urgent need fusobacterium nucleatum f nucleatum periodont pathogen associ varieti oral system diseas thought central develop structur dental plaqu ultra small gold nanoclust aunc prepar exhibit potent antibacteri activ f nucleatum enhanc destruct bacteri membran generat reactiv oxygen speci furthermor due excel penetr aunc could inhibit biofilm format destroy matur biofilm vitro antibiofilm efficaci confirm mous model reduc biofilm accumul amelior inflamm meanwhil disrupt oral gut microbiota caus colon oral f nucleatum could partial restor aunc treatment therefor aunc could consid promis antibiofilm agent great potenti clinic treatment dental plaqu	D016967;D003773	T047;T007
36,329,431	clinic evalu efficaci new bone cement inject cannul pedicl screw treatment spondylolysi type lumbar spondylolisthesi osteoporosi retrospect studi investig clinic efficaci safeti bone cement inject cannul pedicl screw cicp treatment spondylolysi type lumbar spondylolisthesi osteoporosi	D065289;D013168;D013123;D013169;D010024	T061;T047;T074
36,329,430	determin factor associ preval knowledg attitud practic seek skill matern healthcar servic among women remot area gesha district skill health care essenti mother newborn health well pregnanc labor postpartum period studi aim analyz women knowledg attitud practic request compet assist matern healthcar gesha district southwest region ethiopia	D008427;D011248	T058;T046
36,329,429	junctur healthcar qualit studi primari specialist servic use polish migrant england polish peopl biggest migrant group uk scholarship show attent healthcar need seek fulfil use various servic within outsid british public healthcar system articl explor role junctur within healthcar system connect migrant realiz healthcar system sector articl argu transnat context migrant enact junctur join differ level care within sector sector across nation border particular articl explor polish migrant healthcar seek practic within beyond nation border enact given featur avail relationship primari specialist care articul privat public sector	D014171	T098
36,329,428	compar efficaci singl intraarticular inject platelet rich plasma prp combin differ hyaluronan knee osteoarthr random control clinic trial intraarticular plasma rich platelet prp hyaluron acid ha shown effect treat knee osteoarthr oa evid support combin therapi controversi studi aim investig efficaci singl intraarticular prp inject combin differ patient knee oa	D020370;D053657	T047;T031
36,329,427	efficaci safeti uniport video assist thorac surgeri treatment stage ii iii tubercul empyema singl arm clinic retrospect studi thorac surgeri center china surgeri import adjuv treatment tubercul empyema te thus conduct singl arm clinic retrospect studi stage ii iii te patient underw uniport video assist thorac surgeri uni vat year period evalu efficaci safeti surgeri te provid evid optim clinic strategi	D004654;D013903	T047;T091
36,329,426	new surgic techniqu short bowel syndrom short bowel syndrom sbs sever intestin diseas caus malabsorpt long term parent nutrit therapi induc infect liver failur surgic manag intestin rehabilit intestin loop lengthen method serial transvers enteroplasti step method report although effect proven limit herein report new surgic techniqu saeki spiral shark method sbs use biomimet shark intestin	D012778;D013505	T061;T047
36,329,425	deriv asthma sever electron prescript record use british thorac societi treatment step asthma sever typic assess retrospect assess treatment requir control symptom prevent exacerb joint british thorac societi scottish intercollegi guidelin network btssign guidelin encourag stepwis approach pharmacotherapi current treatment step consid sever categoris proxi briefli step adult summaris control therapi step low strength inhal corticosteroid ic step ic plus long act beta agonist laba step medium dose ic laba step final either increas strength addit therapi step studi aim investig btssign step estim across larg cohort use electron prescript record describ incid btssign step general popul	D055695;D001249;D018927	T121;T066;T170;T058;T047
36,329,424	biomechan comparison differ prosthet reconstruct total en bloc spondylectomi finit element studi analys compar biomechan differ print prosthes titanium mesh cage poor match titanium mesh cage total en bloc spondylectomi tes	D014025;D013123	T061;T196
36,329,423	comparison four quasi experiment method analysi introduct activ base fund ireland health servic research often reli quasi experiment studi design estim treatment effect polici chang intervent aim studi compar common use non experiment method estim intervent effect highlight relat strength weak estim effect activ base fund hospit financ reform irish public hospit introduc	D006302;D012107	T062;T096;T170;T081;T169
36,329,422	circul endocannabinoid level pregnant women gestat diabet mellitus case control studi role endocannabinoid ec insulin resist associ viscer obes metabol profil studi extens sinc associ ec metabol factor gestat diabet mellitus gdm clear aim evalu level n arachidonoylethanolamid aea arachidonoylglycerol ag associ c reactiv protein crp glycem indic blood pressur anthropometr indic pregnant women gdm	D016640	T047
36,329,421	operation assent research particip pre adolesc children scope review seek assent children particip medic research ethic imper numer institut global howev none organ provid specif guidanc criteria process use obtain assent primari object scope review determin descript assent discuss literatur report criteria use seek assent research particip pre adolesc children	D007258;D035843	T089;T062
36,329,420	subtot gastrectomi pancreaticoduodenectomi versus convent pancreaticoduodenectomi incid delay gastric empti singl center retrospect cohort studi delay gastric empti dge one common complic pancreaticoduodenectomi pd current wide accept procedur pd reduc incid dge institut attempt perform subtot gastrectomi patient undergo pd reduc dge aim evalu effect safeti pd subtot gastric resect	D016577;D018589	T061;T047
36,329,419	associ mirna mirna express peripher blood mononuclear cell patient multipl sclerosi case control studi microrna mir mirna short regulatori rnas modul post transcript gene express dysregul molecul contribut pathogen autoimmun disord multipl sclerosi ms	D009103;D020529;D035683	T123;T047;T114
36,329,418	valosin contain protein aspg mutat patient frontotempor dementia case report variant valosin contain protein vcp gene identifi one caus inclus bodi myopathi associ paget diseas bone frontotempor dementia ftd previous identifi pathogen variant vcp associ frontotempor lobar degener tdp inclus ftld tdp patholog paspg vcp recent report caus famili ftd tauopathi character neurofibrillari tau tangl nft ftld tdp describ clinic genet find patient paspg valosin contain protein vcp diagnos ftd without famili histori absenc muscl bone diseas comorbid	D057180;D057174;D001847	T047;T048
36,329,417	addit cone beam ct panor imag reduc inferior dental nerv injuri result third molar surgeri systemat review systemat review aim examin whether cone beam ct cbct assess influenc incid nerv injuri follow high risk mandibular third molar mtm surgeri	D008964;D014081	T061;T023
36,329,416	optic coher tomographi angiographi analysi microvascular abnorm vessel densiti treatment nave eye diabet macular edema aim studi evalu structur retin vascular integr use optic coher tomographi angiographi octa treatment nave eye diabet macular edema dme compar find diabet eye without dme	D003930;D008269;D000071071;D003920	T047;T046;T190
36,329,415	associ impuls hyperact inattent nonsuicid self injuri suicid behavior longitudin cohort studi follow children risk neurodevelopment disord mid adolesc knowledg separ attent deficithyperact disord adhd subdimens impuls hyperact inattent associ nonsuicid self injuri nssi suicid behavior sb limit object studi investig associ childhood adhd subdimens nssi sb children risk neurodevelopment disord ndds includ adhd	D016728;D001289	T055;T048
36,329,414	valu nurs led anthropometr oropharyng measur combin stop bang questionnair screen obstruct sleep apnea patient acut coronari syndrom prospect cohort studi obstruct sleep apnea osa modifi risk factor acut coronari syndrom ac high preval low diagnost rate therefor particular import develop strategi better screen osa newli admit ac patient	D054058;D008844;D020181	T019;T047
36,329,413	share compon model earli childhood anaemia malaria kenya malawi tanzania uganda malaria anaemia contribut substanti child morbid mortal studi sought joint model residu spatial variat likelihood two correl diseas control individu level household level environment characterist	D008288;D000740	T047
36,329,412	advanc limit treatment spinal muscular atrophi spinal muscular atrophi q sma sma genet neuromuscular condit affect spinal motor neuron caus defect copi smn gene produc surviv motor neuron smn protein high homolog smn gene primarili express rapid degrad isoform smn protein caus anterior horn cell degener progress motor neuron loss skelet muscl atrophi weak sever case result limit mobil ventilatori insuffici untreat sma lead genet caus death young children recent three therapeut increas smn protein level patient sma provid increment improv motor function development mileston prevent worsen sma symptom therapeut approach spinraza zolgensma evrysdi clinic signific impact curat mani patient remain signific diseas burden potenti combin therapi develop sma target myostatin negat regul muscl mass strength myostatin inhibit anim model increas muscl mass function apitegromab investig fulli human monoclon antibodi specif bind proform myostatin promyostatin latent myostatin therebi inhibit myostatin activ recent complet phase trial demonstr potenti clinic benefit apitegromab improv stabil motor function patient type type sma provid posit proof concept myostatin inhibit target manag sma primari goal manuscript orient physician evolv landscap sma treatment	D009134;D055435	T123;T047;T116
36,329,411	associ preterm birth socioeconom develop analysi nation data increas preval preterm birth global phenomenon attribut increas medic indic artifici gestat socioeconom factor studi conduct identifi whether develop equal indic associ incid preterm birth specif spontan elect preterm birth	D047928	T046
36,329,410	refuge healthcar need barrier access healthcar servic new zealand qualit phenomenolog approach refug asylum seeker specif healthcar need howev insuffici attent effort address need global furthermor effect communic healthcar provid refuge remain poor widen imbalanc power dynam aim research project examin refuge healthcar need current barrier access healthcar servic new zealand propos solut explor percept attitud belief opinion key stakehold regard refuge healthcar need within scaffold health social care system	D012036	T098
36,329,409	global abund short tandem repeat non random rodent primat predomin abund across vertebr genom signific biolog implic relev short tandem repeat strs also known microsatellit speciat remain larg elus attribut random coincid part collect data whole genom abund mono di trinucleotid strs nine speci encompass rodent primat includ rat mous oliv baboon gelada macaqu gorilla chimpanze bonobo human collect data use analyz hierarch cluster str abund select speci	D012377;D006071	T015
36,329,408	two dimension speckl track echocardiographi demonstr improv myocardi function intraven infus bone marrow mesenchym stem x link muscular dystrophi mice bone marrow mesenchym stem cell bmscs common use regen medicin howev clear whether transplant bmscs improv cardiac function x link muscular dystrophi mice mdx detect aim investig role speckl track echocardiographi ste detect cardiac function bmscs transplant mdx comparison untreat mdx	D001853;D020388	T023;T024;T047
36,329,407	chang work condit job relat challeng due sar cov pandem medic assist general practic germani qualit studi germani general practic usual contact first patient health complaint includ symptom characterist sar cov within general practic medic assist mas first contact person patient perform various task close physic patient contact work condit mas character challeng eg due low salari high workload time pressur frequent interrupt potenti chang work condit job relat challeng experienc mas due sar cov pandem fulli explor aim address knowledg gap among mas work general practic germani	D000086402;D000086382	T005;T067;T047
36,329,406	novel method drug target interact predict base graph transform model drug target interact dtis predict becom import acceler drug research drug reposit drug target interact network typic model dtis predict mani differ type relationship exist drug target drug target interact network use model drug target interact relationship recent work drug target interact network most concentr drug node target node neglect relationship drug target	D000465;D000076722	T062;T170;T091
36,329,405	identif key cuproptosi relat gene target patient igan iga nephropathi igan one common form chronic glomerulonephr aetiolog pathogenesi remain unclear cuproptosi newli identifi form cell death play import role mani diseas research clear determin whether express cuproptosi relat gene crgs involv pathogenesi igan	D005922	T047
36,329,404	neonat lupus present neonat hemochromatosi like liver diseas respond steroid case report neonat lupus erythematosus rare multisystem autoimmun disord predomin involv heart congenit heart block involv organ includ liver diseas result passag matern autoantibodi fetus manifest various form depend organ involv neonat lupus liver diseas manifest rang benign elev aminotransferas fatal hepat insuffici iron deposit respond therapi hand case report date antibodi implic sjogren syndrom type b antibodi non specif autoantibodi posit well antinuclear antibodi smooth muscl antibodi classic consid specif autoimmun hepat describ chronic liver diseas describ neonat lupus liver diseas herein report rare case neonat cholestasi due neonat lupus liver diseas present posit smooth muscl antibodi addit biochem pictur neonat hemochromatosi remark elev ferritin respond well steroid therapi	D012859;D008180;D007565;D002779;D006505	T184;T047
36,329,403	complet mitochondri genom updat diverg time two freshwat clupeid endem lake tanganyika africa suggest intralacustrin speciat hydrogeolog histori lake tanganyika paint complex imag sever colon adapt radiat event initi basin form around million year ago mya predecessor malagarasi congo river mya sub basin fuse produc clear deep water today next well known radiat cichlid fish lake also harbour modest clade two clupeid speci stolothrissa tanganica limnothrissa miodon member pellonulini tribe clupeid fish most occur freshwat colon west central africa period high sea level cenozo consensus phylogenet relationship member pellonulini time colon lake tanganyika clupeid	D054629;D023681	T028;T013
36,329,402	associ dietari inflammatori potenti probabl sarcopenia among communiti dwell older adult cross section studi unlik numer studi concern role dietari inflammatori potenti chronic diseas limit studi focus associ dietari inflammatori potenti handgrip strength hgs probabl sarcopenia ps studi tend explor associ dietari inflammatori potenti ps among older adult tehran	D055948	T047

36,329,513

efficaci safeti treamid rehabilit patient covid pneumonia phase random doubl blind placebo control trial mani patient recov covid still suffer pulmonari dysfunct persist even month infect therefor treatment prevent irrevers impair lung function need treamid bisamid deriv dicarboxyl acid bdda shown anti inflammatori antifibrot effect anim model pulmonari fibrosi studi design assess safeti toler efficaci treamid rehabilit patient covid pneumonia aim establish whether treamid could effect amelior post covid sequela

D000086382

T047;T067

36,329,512

blood base lipidom signatur sever obstruct sleep apnoea alzheim diseas obstruct sleep apnoea osa frequent form sleep disord breath patient alzheim diseas ad avail evid demonstr condit independ associ alter lipid metabol howev unknown whether express lipid differ ad patient without sever osa context examin plasma lipidom patient suspect osa aim identifi potenti diagnost biomark provid insight pathophysiolog mechan under diseas

D000544;D020181

T047;T048

36,329,510

segreg stabilis plasmid improv product commod chemic glucos limit continu ferment product chemic via bio base rout held back limit easi use stabilis system wide rang plasmid stabilis mechan found literatur howev mechan effect genet stabil host strain still revert non product variant poor understood singl cell level phenomenon generat difficulti product scale bioreactor differ popul product non product cell aris understand prevent non product strain aris vital understand strain behaviour singl cell level persist gene locat plasmid vector depend numer factor broad separ structur stabil segreg stabil structur stabil refer capabl cell resist genet mutat bring loss gene function product pathway segreg stabil refer capabl cell correct distribut plasmid daughter cell maintain copi number lack segreg stabil rapid generat plasmid free variant replic compromis product

D004926;D005947

T121;T123;T007;T109

36,329,508

isol identif broad spectrum high effici phage vbsalpldw therapeut applic chicken salmonella infect livestock poultri caus salmonellosi main treat use antibiot howev misus use antibiot often trigger emerg multi drug resist salmonella strain current salmonella phage safe effect salmonella serv best drug choic studi involv salmonella bacteriophag separ purifi sewag fece broiler farm phage vbsalpldw select base phage host rang test phage vbsalpldw character doubl layer plate method transmiss electron microscopi furthermor clinic therapeut effect phage vbsalpldw verifi use pathogen salmonella enteritidi spf chicken model

D001435;D012480;D012478

T005;T037;T047

36,329,506

integr rehabilit servic primari health care polici option iran provid rehabilit servic primari health care phc associ numer health social econom benefit therefor low middl incom countri iran benefit advantag integr rehabilit servic phc conduct qualit studi determin polici solut could facilit integr rehabilit servic iran phc network

D011320;D003695

T058;T093

36,329,505

character diazotroph root endophyt chines silvergrass miscanthus sinensi phytoremedi potenti cost effect way remedi high contamin mine tail site howev nutrient limit especi defici nitrogen n hinder growth plant impair phytoremedi mine tail nevertheless pioneer plant success colon mine tail exhibit potenti tail phytoremedi diazotroph especi diazotroph endophyt promot growth host plant test mine tail habitat combin field sampl dna stabl isotop probe sip analysi pot experi

D060026;D006109

T004;T002

36,329,504

singl cell rna sequenc reveal rebalanc immunolog respons patient periodont non surgic periodont therapi periodont major inflammatori diseas oral mucosa limit oral caviti also system consequ although import chronic periodont emphas system immun respons induc periodont therapeut effect remain elus report transcriptom peripher blood mononuclear cell pbmcs patient periodont

D052243;D055113

T125;T047;T116

36,329,503

pfo morpholog evalu c tcd c tte rls grade purpos studi observ morpholog characterist patent foramen oval pfo transesophag echocardiographi tee analyz correl right left shunt rls contrast transthorac echocardiographi c tte contrast transcrani doppler ultrasonographi c tcd

D054092

T019

36,329,500

associ habitat autogeni genet moroccan culex pipien popul mosquito culex pipien complex found across globe focus mani research studi among temper speci c pipien sensu stricto ss two form usual describ molestus pipien two form indistinguish term morpholog show behavior physiolog differ may consequ associ epidemiolog two form well defin northern part speci distribut autogeni strict associ molestus form howev whether two remain distinct show characterist differ behavior less clear north africa southern edg rang

D003465

T204

36,329,499

observ studi investig relationship plasma glucosylsphingosin lyso gb concentr treatment outcom patient gaucher diseas japan gaucher diseas gd autosom recess diseas caus gba mutat result glucosylceramid accumul macrophag gd character hepatosplenomegali anemia thrombocytopenia bone complic neurolog complic glucosylsphingosin lyso gb deacyl form glucosylceramid identifi promis biomark diagnosi treatment respons gd aim studi examin relationship plasma lyso gb therapeut goal gd improv hepatomegali splenomegali anemia thrombocytopenia bone pain bone crisi well diseas type gba mutat type japanes patient gd receiv velagluceras alfa enzym replac therapi ert furthermor studi compar plasma lyso gb concentr observ japanes patient includ studi observ previous non japanes clinic studi

D005776;D013921

T047

36,329,498

oral viscer iatrogen kaposi sarcoma follow treatment acut lymphoblast leukemia case report review literatur hard report case children present kaposi sarcoma second malign follow treatment acut lymphoblast leukemia outsid transplant set

D012514;D016609;D054198;D010157

T191

36,329,497

carbon dot deriv folic acid attenu osteoarthr protect chondrocyt nf bmapk pathway reprogram macrophag osteoarthr oa common joint disord worldwid caus great health econom burden howev remain unmet goal develop effect therapeut method prevent delay oa chondrocyt major cell involv oa progress may serv promis therapeut target

D019902;D010003

T047;T025

36,329,496

plasma adiponectin level predict cognit declin cortic thin mild cognit impair beta amyloid patholog blood adiponectin leptin adipokin emerg potenti biomark predict alzheim diseas ad owe strong connect obes although obes affect relat beta amyloid aggreg cognit declin longitudin interact effect adipokin cognit brain structur human remain unexplor henc investig whether plasma level adiponectin leptin associ futur cognit declin cortic thin across condit individu mild cognit impair mci

D000544;D060825

T047;T048

36,329,495

evid pituitari gland connect type diabet mellitus schizophrenia base larg scale tran ethnic genet analys previous studi european eur sampl obtain inconsist result regard genet correl type diabet mellitus tdm schizophrenia scz larg scale tran ethnic genet analysi may provid addit evid enhanc power

D012559;D003924

T047;T048

36,329,494

risk factor nineti day readmiss follow cervic surgeri meta analysi import evalu index cervic surgeri nineti day readmiss gradual valu studi collect latest publish relev studi analyz risk factor nineti day readmiss cervic surgeri continu improv postop rehabilit plan studi focus two research hotspot rate nineti day readmiss cervic surgeri risk factor affect nineti day readmiss

D008171;D006331;D006973

T047

36,329,492

neuron matter neuromodul electromagnet stimul must consid neuron dynam ident neuromodul electromagnet stimul wide use control abnorm neural activ proven valuabl altern pharmacolog tool treatment mani neurolog diseas tremend effort focus design stimul apparatus ie electrod magnet coil deliv electr current neural tissu optim stimul paramet less attent given complic dynam properti neuron context depend impact stimul effect review focus neuron factor influenc outcom electromagnet stimul neuromodul evid multipl level tissu cellular singl ion channel review properti neural element dynam chang play signific role outcom electromagnet stimul angl understand yield comprehens perspect neural activ electr neuromodul provid insight design develop novel stimul technolog

D050781;D009422

T062;T047;T061

36,329,491

visual clonal expans massiv deplet cell carri bovin leukemia virus blv integr site cours diseas progress blv natur infect cow case report bovin leukemia virus blv infect cattl integr host dna provirus induc malign b cell lymphoma previous studi address impact provir integr blv blv induc leukemogenesi howev studi monitor sequenti chang integr site natur infect blv individu progress premalign stage termin diseas collect blood sampl singl natur infect holstein cow three diseas progress stage stage polyclon stage stage ii polyclon toward oligoclon stage stage iii oligoclon stage success visual kinet clonal expans cell carri blv integr site use blv provir dna captur sequenc method although integr site detect stage ii site experienc massiv deplet stage iii site locat within intron refseq gene intergen region repetit sequenc respect stage iii cattl lymphoma two integr site generat de novo intergen region chr intron chek gene chr signific increas result first demonstr clonal expans massiv deplet cell carri blv integr site natur infect cow

D001909;D016583

T005;T191

36,329,489

public awar knowledg sepsi cross section survey adult canada sepsi life threaten complic bodi respons infect financi medic psycholog cost sepsi individu healthcar system high sepsi case origin communiti make public awar sepsi essenti earli diagnosi treatment comprehens examin adult sepsi knowledg canada

D000086382;D018805

T047;T046;T067

36,329,488

age relat radiograph paramet differ degen lumbar spinal stenosi patient healthi peopl correl analysi identifi age relat radiograph risk factor degen lumbar spinal stenosi dlss analyz correl among

D013130;D055959

T047;T020;T190

36,329,487

appar mineralocorticoid excess comprehens overview molecular genet appar mineralocorticoid excess autosom recess form monogen diseas character juvenil resist low renin hypertens mark hypokalem alkalosi low aldosteron level high ratio cortisol cortison metabolit caus defect hsdb gene encod enzym hydroxysteroid dehydrogenas type hsd primarili involv peripher convers cortisol cortison date deleteri hsdb mutat identifi worldwid multipl molecular mechan function lower hsd activ includ damag protein stabil lower affin substrat cofactor disrupt dimer interfac genet polymorph environment factor well epigenet modif may also offer implicit explan molecular pathogenesi ame precis diagnosi depend genet test allow earli specif manag avoid morbid mortal target organ damag review provid insight molecular genet classic non classic appar mineralocorticoid excess aim offer comprehens overview monogen diseas

D003348;D006973

T125;T121;T047;T109

36,329,486

cross site collabor infect prevent control research room improv year compar studi five european countri spread sar cov multidrug resist organ healthcar associ pathogen repres supra region challeng infect prevent control ipc specialist everi european countri tackl problem cross site research collabor ipc specialist import studi assess extent qualiti nation research collabor ipc depart univers hospit locat austria england franc germani netherland identifi network gap provid potenti solut

D003428;D000086382

T047;T067

36,329,485

research implement interact social account studi util guidanc conduct process evalu complex intervent recent year research evalu made effort identifi use appropri innov research design account complex studi social account relationship research implement activ impact studi receiv littl attent paper reflect manag relationship research implement use unit kingdom medic research council mrc guidanc process evalu complex intervent

D012941;D012108

T078;T097;T054

36,329,483

comprehens genotyp phenotyp evalu eight chines proband waardenburg syndrom waardenburg syndrom ws common form syndrom deaf phenotyp genet heterogen chines popul studi aim clarifi clinic characterist genet caus eight chines ws famili includ three famili five sporad case genotyp phenotyp relationship also investig

D014849

T047

36,329,482

earli intub clinic outcom patient sever covid systemat review meta analysi evid regard time applic mechan ventil among patient sever coronavirus diseas covid insuffici systemat review meta analysi aim evalu effect earli intub compar late intub patient sever critic covid

D000086382

T047;T067

36,329,481

lower gestat age associ lower cortic volum cognit educ perform adolesc gestat age ga associ later cognit behavior howev unclear specif cognit domain brain structur develop vari stepwis chang gestat durat

D007234;D001921

T033;T023;T100

36,329,478

primari squamous cell carcinoma thyroid gland case report popul base studi primari squamous cell carcinoma thyroid gland pscct high aggress malign tumor associ poor prognosi due rare case knowledg gap featur pscct limit understand treatment molecular biolog tumor genom work relev perspect work need done

D013964;D002294

T191

36,329,477

high preval canin heartworm dirofilaria immiti pet dog south texa usa evid aed aegypti mosquito contribut transmiss canin heartworm dirofilaria immiti filarioid nematod dog carnivor widespread usa world differ mosquito speci serv intermedi host immiti contribut transmiss vari accord factor like host feed pattern geograph locat climat condit yellow fever mosquito aed aegypti compet vector immiti often dismiss vector veterinari relev given anthropophil feed behavior evalu preval immiti pet dog along usa mexico border assess whether ae aegypti area natur infect heartworm potenti act vector

D004183;D000330;D004184;D004283

T047;T204

36,329,476

earli life antibiot exposur increas risk childhood overweight obes relat dysbiosi gut microbiota birth cohort studi earli life antibiot exposur associ develop later obes disrupt gut microbiota anim model howev relat epidemiolog evid still conflict

D000069196;D063766

T033;T047;T007;T001

36,329,474

assess genet burden famili hypercholesterolemia larg middl eastern biobank genet architectur under famili hypercholesterolemia fh middl eastern arab yet fulli describ approach assess popul wide biobank import public health plan person medicin

D000071449;D006938

T047;T126;T116

36,329,473

learn base control approach servic robot cloth manipul dress assist comprehens review servic robot defin reprogramm sensor base mechatron devic perform use servic autonom semi autonom way human activ everyday environ number elder peopl grow servic robot oper complex task like dress task disabl peopl demand increas consequ grow interest studi dress task put shirt hat shoe servic robot robot manipul develop accomplish task use sever control approach robot use kind applic usual bimanu manipul ie baxter robot singl manipul ie ur robot arm usual use recogn cloth fold put item arm head person

D012371;D006233

T090;T101

36,329,472

associ chiropract integr ontario communiti health centr continu prescript opioid use chronic non cancer spinal pain sequenti explanatori mix method studi emerg evid suggest access chiropract care may reduc likelihood initi opioid prescript spinal pain howev impact chiropract care patient alreadi prescrib opioid uncertain undertook sequenti explanatori mix method studi evalu associ initi chiropract care continu opioid use among adult patient attend ontario communiti health centr chc receiv opioid therapi chronic non cancer spinal pain

D059350;D002684;D009293

T184;T047;T091;T048

36,329,471

take cat mous game next level differ perspect introduct german new psychoact substanc act counteract spread new psychoact substanc nps prevent emerg novel substanc specif design respons legal control individu substanc new law introduc germani new psychoact substanc act npsg npsg combin generic approach waiver crimin liabil acquisit possess nps person use novelti german narcot law present studi aim explor impact introduct npsg three differ perspect nps user staff addict care facil member law enforc author better understand dynam surround chang legisl contribut bodi intern experi deal nps

D011619;D007880

T089;T121

36,329,470

explor risk factor cervic lymph node metastasi papillari thyroid microcarcinoma construct novel popul base predict model machin learn high effect tool model construct aim establish machin learn base predict model predict cervic lymph node metastasi lnm papillari thyroid microcarcinoma ptmc

D001185;D013964

T090;T191;T073;T066

36,329,469

landscap hervrna transcrib human endogen retrovirus across human bodi site human endogen retrovirus herv remnant ancient retrovirus account human genom lost transcript abil physiolog condit howev mount evid show sever express herv exert biolog function systemat character physiolog express herv examin whether may give insight molecular fundament human develop diseas

D020077

T005

36,329,468

systemat evalu pre eclampsia drug dietari supplement biolog pipelin use target product profil acceler innov mother aim project establish databas candid medicin research develop r five pregnanc relat condit includ pre eclampsia parallel publish target product profil tpps describ optim characterist medicin use preventingtr pre eclampsia studi object use systemat doubl screen extract identifi candid medicin investig pre eclampsia preventiontreat rank potenti base tpps

D011225;D001688;D008687

T121;T123;T046;T109

36,329,467

limb acceler sleep relat measur strength sensat spastic among individu spinal cord injuri evalu relationship measur neuromuscular impair limb acceler la collect sleep among individu chronic spinal cord injuri sci provid evid construct concurr valid la clinic meaning measur

D009128;D013119

T184;T037;T048

36,329,466

attitud polish physician nurs pharmacist toward ethic legal aspect conscienc claus healthcar profession right invok conscienc claus recognis fundament human right continu provok heat debat polish societi although public discours fill ethic legal consider conscienc claus much less known attitud healthcar profession regard matter aim studi therefor describ attitud polish physician nurs pharmacist toward ethic legal aspect conscienc claus

D003242;D010820

T097;T041

36,329,465

dual target nanozym tumor activat photo chemodynam theranost tumor phototheranost hold great promis account high spatiotempor resolut tumor specif noninvas howev physic limit light penetr alway properti convent phototherm convers agent usual caus difficulti accur diagnosi complet elimin tumor meanwhil nanozym mediat fenton reaction well util tumor microenviron tme generat hydroxyl radic chemodynam therapi cdt limit concentr h tme deliveri effici nanozym overcom problem dual target nanozym ftrnps develop tumor specif situ theranost base upon assembl ultrasmal fe nanoparticl tetrameth ylbenzidin tmb rgd peptid ftrnps h treatment exhibit superior phototherm stabil high phototherm convers effici ftrnps show extraordinari accumul retent tumor site biologicalphys dual target fold higher without activ target cascad dual respons tme nanozym mediat fenton reaction tmb oxid improv accuraci photoacoust imag phototherm therapi ptt tumor inhibit rate photo chemodynam therapi fold higher ptt cdt thus combin cdt ptt construct turn nanoplatform great signific overcom respect limit consid optim one perform new nanoplatform expect provid advanc theranost strategi futur treatment cancer

D009369;D053758

T191;T073

36,329,464

defect microtubul cytoskelet organ noa human test import actin microtubul mt cytoskeleton testi function rodent known extent role etiolog azoospermia human remain unexplor examin mt cytoskeleton defect noa non obstruct azoospermia test versus normal human test base histopatholog immunofluoresc scrna seq transcriptom profil testi biopsi sampl n normal men versus n sertoli cell sco n meiotic arrest noa patient use histopatholog analysi analysi also use examin mt organ across seminifer epithelium investig like involv microtubul associ protein map scrna seq transcriptom profil dataset test sco patient versus normal men public domain gene express omnibus geo sampl gsm identifi analyz examin relev gene regul mt dynam noa test sco patient display notabl defect mt organ across epithelium extens truncat mis align appear collaps structur near base tubul chang contrast mts test normal men scrna seq analys reveal consider loss spermatogenesi capac sco test noa patient versus normal men array gene support mt dynam display consider chang express spatial distribut summari defect mt cytoskeleton note test noa sco patient possibl mediat defect spatial express andor distribut map chang turn may imped spermatogenesi sco test noa patient

D053713

T047

36,329,463

later approach aesthet option radic resect bscc assess surgic oncolog function aesthet outcom purpos studi introduc modifi later approach combin radic resect buccal squamous cell carcinoma bscc evalu surgic oncolog function aesthet outcom comparison convent lower lip split approach

D004955;D002294

T191;T091

36,329,462

inferior sublux humer head osteosynthesi greater tuberos fractur inferior sublux humer head frequent observ immedi surgeri proxim humerus fractur howev incid risk factor inferior sublux osteosynthesi isol greater tuberos fractur remain unsolv addit postop cours inferior sublux elucid purpos present studi identifi predictor occurr postop inferior sublux multivari analysi investig postop shift inferior sublux effect surgic outcom

D012784;D004204

T037

36,329,461

implement threefold intervent improv palliat care person experienc homeless process evalu use aim framework palliat care provis person experienc homeless often poor threefold consult servic intervent expect increas knowledg palliat care multidisciplinari collabor improv palliat care popul intervent compris consult social servic profession palliat care specialist vice versa multidisciplinari meet profession train educ profession aim evalu implement process barrier facilit servic implement within social servic healthcar organ three dutch region

D000086382;D006703;D064946

T098;T058;T091;T067;T033;T047;T095

36,329,460

sepax cell process devic studi assess reproduc concentr thaw hematopoiet progenitor cell autolog hematopoiet progenitor cell hpc transplant current standard care fraction patient newli diagnos myeloma relaps refractori lymphoma high dose chemotherapi cryopreserv hpc either infus direct bedsid thaw wash concentr infus previous report compar washingconcentr hpc post thaw vs infus without manipul term hematopoiet engraft yet settl prior favor cell debri dmso remov almost two decad autom critic step washingconcentr cell feasibl part continu process verif aim evalu reproduc procedur assess intra batch inter batch variabl upon concentr thaw hpc product use sepax cell separ system

D006412;D018380

T061;T025

36,329,459

shoulder work relat musculoskelet disord relat factor worker industri china cross section studi chang modern industri product practic easili lead shoulder work relat musculoskelet disord wmsd current report shoulder wmsd limit industri less well studi sampl size usual small studi aim describ preval sever shoulder wmsd larg sampl chines worker industri analyz possibl correl sociodemograph work relat variabl compar differ industri

D009784;D009140

T047

36,329,458

associ angiotensin convert enzym insertiondelet ace id gene polymorph suscept prostat cancer updat meta analysi meta analysi aim explor associ angiotensin convert enzym ace insertiondelet id gene polymorph suscept prostat cancer pca

D020022;D011471

T032;T191

36,329,457

risk indic dental cari gingiv among year old children nigeria household base survey littl known factor associ cari experi gingiv among year old children nigeria aim studi determin preval prevent oral health behavior associ cari gingiv among year old children nigeria

D003731;D005891

T033;T047

36,329,456

triglycerid glucos index risk heart failur evid two larg cohort mendelian random analysi relationship triglycerid glucos tyg index emerg marker insulin resist risk incid heart failur hf unclear studi thus aim investig relationship

D005947;D006333

T123;T121;T109;T047;T046

36,329,455

evolv trust respons covid pandem among migrant norway covid pandem profound consequ world popul particular vulner group like migrant face barrier healthcar access trust author crucial crisi manag strategi implement govern howev trust author link trust area life evolv crisi studi explor migrant trust norwegian govern respons covid pandem

D000086382;D058873;D014171;D035502

T054;T047;T098;T067

36,329,454

malaria diagnost treatment practic febril children year two general hospit karamoja high transmiss set uganda malaria one lead caus morbid mortal among children year age uganda although karamoja sub region highest preval malaria one highest case fatal rate children year inform malaria case manag sub region scarc studi evalu malaria diagnost treatment practic well factor associ inappropri care children year age present fever two public hospit within sub region

D000962;D008288

T121;T047

36,329,453

mediat effect vascular risk factor under link gestat diabet cardiovascular diseas women gestat diabet gdm elev lifetim incid cardiovascular diseas cvd basi excess risk remain establish context hypothes chronic exposur advers cardiovascular risk factor may contribut elev risk cvd thus sought quantifi determin cvd risk women histori gdm perform mediat analys

D016640;D002318

T047

36,329,452

potenti montmorillonit modifi organosulfur surfact reduc aflatoxin b toxic rumin methanogenesi vitro montmorillonit clay modifi organosulfur surfact possess high cation exchang capac cec adsorpt capac unmodifi form um therefor may elev advers impact aflatoxin b afb rumin ferment methanogenesi chemic mechan modif use innov organ modifi nano montmorillonit mnm um modifi use sodium dodecyl sulfat sds ground obtain nanoscal particl size form dose respons effect mnm supplement basal diet contamin afb ppb evalu vitro use gas product gp system follow treatment test control basal diet without supplement um diet um supplement mg kg dri matter dm mnm diet low mg kg dm high dose mg kg dm

D016604;D012417

T131;T196;T023;T109

36,329,451

rethink rural use hospit referr region investig rural urban health outcom rural resid unit state face disproportion poorer health outcom compar urban resid studi aim establish continu rural urban measur hospit referr region hrrs us investig relationship proport rural popul serv hrr health outcom healthcar spend util access qualiti primari care

D012424;D006278

T064;T089;T098;T102

36,329,450

similar cost outcom differenti servic deliveri model hiv treatment uganda cost outcom studi estim perspect servic provid total annual cost per client antiretrovir therapi art total annual cost per client viral suppress defin year old enrol dsdm studi found retent care sampl whole viral suppress mean cost provid moh ngo implement per annum per client treat rang differ among model cost larg due client arv regimen proport client second line regimen servic deliveri cost exclud arv medicin laboratori test modest rang per client per year conclud differenti art servic deliveri uganda achiev excel treatment outcom cost similar standard care larg budgetari save might immedi realiz realloc save staff time could improv health system effici equival better outcom larg benefit client client centr differenti model would nevertheless add great societ valu

D015658;D019380

T121;T047

36,329,449

breakag risk differ sacroiliac screw unilater sacral fractur finit element analysi compar breakag risk lengthen sacroiliac screw ordinari sacroiliac screw treat unilater vertic sacral fractur provid refer clinic applic

D050723;D016103

T037

36,329,448

hif caspas express aggress papillari thyroid carcinoma tumor cell adapt hypoxia regul transcript factor involv regul metabol angiogenesi cell prolifer apoptosi hypox condit hypoxia induc factor hif consist hif hif subunit act key transcript factor mediat adapt cellular respons caspas key apoptosi relat proteas play role tumor growth develop studi shown caspas could regul hif patholog condit therefor hif caspas express may relat poor prognosi tumor studi analyz possibl relationship two signal factor correl clinic behavior ptc

D051795;D013964

T123;T191;T116

36,329,446

tripartit motif contain protein acceler influenza hn virus infect promot k link ubiquitin tbk avian influenza hn emerg threaten public health caus acut respiratori distress syndrom even death human popul howev under mechan hn virus caus human infect remain elus

D064766;D005585;D007251;D007370

T129;T121;T116;T005;T047

36,329,445

pregnanc sexual relat problem among women live street dire dawa citi eastern ethiopia qualit studi problem women youth live street global phenomenon creat countless problem live street unwant pregnanc sexual exploit prostitut frequent observ see women beg street major citi ethiopia one two babi side studi give depth understand distress high challeng problem among women street regard pregnanc relat problem

D012725;D012749

T055;T053;T032;T047

36,329,444

import earli diagnosi view newborn screen metachromat leukodystrophi result caregiv survey uk republ ireland metachromat leukodystrophi mld rare autosom recess lysosom storag disord caus defici enzym arylsulfatas arsa mld caus progress loss motor function sever declin cognit function lead prematur death earli diagnosi mld provid opportun begin treatment diseas progress caus sever disabl mld current includ newborn screen nbs ukthi studi consist onlin survey follow semi structur interview open mld patient caregiv age year aim studi understand import earli diagnosi establish view famili caregiv patient mld nbsa total patient took part survey repres famili two famili two children mld one famili three children mld follow survey six parent particip interview data show diagnost delay first symptom year median year n time deterior rapid especi earlier onset mld patient late infantil mld n wheelchair depend unabl speak tube fed diagnosi mld confirm patient earli juvenil mld n half use wheelchair time uncontrol cri difficulti speak time diagnosi high degre support express nbs among caregiv describ extrem import believ detect mld birth would chang child futur one parent express gratitud earli diagnosi result famili mld screen offer birth chang child futur absolut forev grate earli diagnosi thank older sister rapid rate deterior mld make essenti candid nbs particular first gene therapi libmeldi approv european medicin agenc libmeldi also recommend treatment option england wale nation institut health care excel nice made avail patient scotland via scottish medicin consortium ultra orphan pathway

D007966

T047

36,329,443

anxieti depress post pandem era concern viral mutat outbreak coronavirus pandem covid rage month put signific strain public health system around world despit fact pandem effect manag certain countri region outbreak viral mutat continu pose threat peopl live likelihood post pandem chang peopl psycholog situat warrant investig

D058873;D000086382

T047;T067

36,329,442

new proof evid cysteamin quantif therapeut drug monitor patient cystinosi date measur intracellular cystin use therapeut monitor patient affect cystinosi treatment cysteamin sinc method time sampl consum develop faster method quantifi cysteamin would extrem use order help clinician adjust dosag cysteamin defin better pharmacokinet profil drug aim studi develop liquid chromatographi tandem mass spectrometri method quantif cysteamin plasma sampl test applic plasma sampl deriv patient nephropath infantil cystinosi treatment cysteamin

D003554

T047

36,329,441

venturia inaequali effector repertoir domin expand famili predict structur similar unrel sequenc avirul protein plant pathogen fungi scab caus biotroph fungus venturia inaequali econom import diseas appl worldwid infect v inaequali occupi subcuticular environ secret virul factor term effector promot host colon consist plant pathogen fungi mani effector expect non enzymat protein recogn correspond host resist protein activ plant defenc thus act avirul determin develop durabl control strategi scab better understand role effector protein play promot subcuticular growth v inaequali well activ suppress circumv resist protein mediat defenc appl requir

D001203;D027845

T168;T004;T002

36,329,440

tailor optim fatti acid product oleagin yeast systemat explor physiolog fit use palm oil current need unsustain replac palm oil oil produc microb convers sustain feedstock promis altern howev major technic challeng must overcom enabl transit foremost among challeng stark increas lipid accumul product higher content specif fatti acid therefor need depth knowledg systemat explor oil product oleagin yeast studi cultiv cutaneotrichosporon oleaginosus yarrowia lipolytica various cn ratio temperatur defin medium glycerol carbon sourc urea nitrogen sourc ascertain synergist effect various cn ratio defin medium differ temperatur respons surfac methodolog rsm explor variat fatti acid composit princip compon analysi

D005227;D025062

T123;T168;T004;T109

36,329,439

pharmaci locat medic need region evid canada pharmacist canada assum increas import role provis primari care servic rais question access pharmaci servic among medic care need evid proxim resid ontario nova scotia communiti pharmaci littl evid rest canada thus measur avail pharmacist servic number communiti pharmaci hour oper provinci sub provinci level canada next measur associ indic medic need avail pharmacist servic across sub provinci unit

D010594;D003157;D010604

T091;T073;T093;T058;T057

36,329,438

postop pedicl screw posit dorsal instrument without intraop cone beam ct imag wors patient obes normal weight patient intraop cone beam ct cbct imag dorsal instrument facilit pedicl screw posit howev patient obes benefit may reduc due artifact affect imag qualiti purpos studi evalu whether intraop cbct lead improv postop screw posit compar convent fluoroscopi independ bodi weight

D065289;D013123;D025321

T061;T074

36,329,437

complet respons nivolumab kirsten rat sarcoma virus oncogen kras gc mutant metastat lung adenocarcinoma case report advent immunotherapi usher new era treatment non small cell lung carcinoma although immunotherapi associ improv clinic outcom studi report median overal surviv month progress free surviv month use nivolumab pretreat metastat non small cell lung cancer herein describ case advanc non small cell lung carcinoma shown except respons immunotherapi patient complet respons past year sinc commenc nivolumab

D002289;D008175;D000077192

T191

36,329,436

ferroptosi assassin tumor near million peopl got cancer near million peopl die cancer indic cancer remain great threat human health life new therapi still urgent demand develop novel cancer therapi name ferroptosi assassin tumor fast combin iron oxid nanoparticl cancer select knockdown seven key ferroptosi resist gene fpn lcn fth fsp gpx slca nrf found fast notabl anti tumor activ varieti cancer cell littl effect normal cell especi fast erad three differ type tumor leukemia colon cancer lung metastat melanoma cancer mice make mice surviv day without tumor relaps fast also signific inhibit prevent growth spontan breast cancer improv surviv mice fast show high pan anti tumor efficaci high cancer specif vivo safeti fast defin new form advanc nanomateri advanc combinatori nanomateri combin two kind nanomateri chemic nanomateri iron oxid nanoparticl biochem nanomateri adeno associ virus success turn general iron nanomateri unpreced assassin cancer

D000079403;D008175;D001943

T191;T043

36,329,435

comparison frailti patient nontubercul mycobacteri lung diseas bronchiectasi prospect cohort studi incid nontubercul mycobacteri lung diseas ntm ld peak middl old age group coincid senesc thus chronic infecti diseas acceler frailti worsen mental health elder studi aim compar preval physic psychiatr frailti patient ntm ld bronchiectasi

D001987;D000073496;D009165;D011014

T184;T050;T033;T047;T046

36,329,434

donor age effect vitro chondrogen osteogen differenti perform equin bone marrow adipos tissu deriv mesenchym stromal cell bone marrow bm adipos tissu deriv mesenchym stromal cell mscs shown potenti cell base therapi cartilag bone injuri use increas human veterinari practic facilit treatment orthoped condit howev human rodent studi document sharp declin chondrogen osteogen differenti potenti increas donor age may problemat import demograph older orthoped patient aim studi identifi effect donor age chondrogen osteogen differenti perform equin bm mscs vitro bm mscs dermal fibroblast biolog negat control harvest hors five differ age group n n newborn day yearl month adult year middl age year geriatr year chondrogen differenti perform assess quantit measur pellet size matrix proteoglycan level gene express articular cartilag biomark osteogen differenti perform assess quantit measur alkalin phosphatas activ calcium deposit gene express bone biomark

D010012;D059630

T025;T042

36,329,433

knowledg attitud practic univers student regard covid cross section studi vietnam cross section studi investig knowledg attitud practic kap vietnames univers student regard covid

D000086382

T047;T067

36,329,432

antibiofilm activ ultra small gold nanoclust fusobacterium nucleatum dental plaqu biofilm pathogen dental plaqu biofilm univers harm result oral infect system diseas mani convent therapeut method proven insuffici ineffect plaqu biofilm therefor new strategi urgent need fusobacterium nucleatum f nucleatum periodont pathogen associ varieti oral system diseas thought central develop structur dental plaqu ultra small gold nanoclust aunc prepar exhibit potent antibacteri activ f nucleatum enhanc destruct bacteri membran generat reactiv oxygen speci furthermor due excel penetr aunc could inhibit biofilm format destroy matur biofilm vitro antibiofilm efficaci confirm mous model reduc biofilm accumul amelior inflamm meanwhil disrupt oral gut microbiota caus colon oral f nucleatum could partial restor aunc treatment therefor aunc could consid promis antibiofilm agent great potenti clinic treatment dental plaqu

D016967;D003773

T047;T007

36,329,431

clinic evalu efficaci new bone cement inject cannul pedicl screw treatment spondylolysi type lumbar spondylolisthesi osteoporosi retrospect studi investig clinic efficaci safeti bone cement inject cannul pedicl screw cicp treatment spondylolysi type lumbar spondylolisthesi osteoporosi

D065289;D013168;D013123;D013169;D010024

T061;T047;T074

36,329,430

determin factor associ preval knowledg attitud practic seek skill matern healthcar servic among women remot area gesha district skill health care essenti mother newborn health well pregnanc labor postpartum period studi aim analyz women knowledg attitud practic request compet assist matern healthcar gesha district southwest region ethiopia

D008427;D011248

T058;T046

36,329,429

junctur healthcar qualit studi primari specialist servic use polish migrant england polish peopl biggest migrant group uk scholarship show attent healthcar need seek fulfil use various servic within outsid british public healthcar system articl explor role junctur within healthcar system connect migrant realiz healthcar system sector articl argu transnat context migrant enact junctur join differ level care within sector sector across nation border particular articl explor polish migrant healthcar seek practic within beyond nation border enact given featur avail relationship primari specialist care articul privat public sector

D014171

T098

36,329,428

compar efficaci singl intraarticular inject platelet rich plasma prp combin differ hyaluronan knee osteoarthr random control clinic trial intraarticular plasma rich platelet prp hyaluron acid ha shown effect treat knee osteoarthr oa evid support combin therapi controversi studi aim investig efficaci singl intraarticular prp inject combin differ patient knee oa

D020370;D053657

T047;T031

36,329,427

efficaci safeti uniport video assist thorac surgeri treatment stage ii iii tubercul empyema singl arm clinic retrospect studi thorac surgeri center china surgeri import adjuv treatment tubercul empyema te thus conduct singl arm clinic retrospect studi stage ii iii te patient underw uniport video assist thorac surgeri uni vat year period evalu efficaci safeti surgeri te provid evid optim clinic strategi

D004654;D013903

T047;T091

36,329,426

new surgic techniqu short bowel syndrom short bowel syndrom sbs sever intestin diseas caus malabsorpt long term parent nutrit therapi induc infect liver failur surgic manag intestin rehabilit intestin loop lengthen method serial transvers enteroplasti step method report although effect proven limit herein report new surgic techniqu saeki spiral shark method sbs use biomimet shark intestin

D012778;D013505

T061;T047

36,329,425

deriv asthma sever electron prescript record use british thorac societi treatment step asthma sever typic assess retrospect assess treatment requir control symptom prevent exacerb joint british thorac societi scottish intercollegi guidelin network btssign guidelin encourag stepwis approach pharmacotherapi current treatment step consid sever categoris proxi briefli step adult summaris control therapi step low strength inhal corticosteroid ic step ic plus long act beta agonist laba step medium dose ic laba step final either increas strength addit therapi step studi aim investig btssign step estim across larg cohort use electron prescript record describ incid btssign step general popul

D055695;D001249;D018927

T121;T066;T170;T058;T047

36,329,424

biomechan comparison differ prosthet reconstruct total en bloc spondylectomi finit element studi analys compar biomechan differ print prosthes titanium mesh cage poor match titanium mesh cage total en bloc spondylectomi tes

D014025;D013123

T061;T196

36,329,423

comparison four quasi experiment method analysi introduct activ base fund ireland health servic research often reli quasi experiment studi design estim treatment effect polici chang intervent aim studi compar common use non experiment method estim intervent effect highlight relat strength weak estim effect activ base fund hospit financ reform irish public hospit introduc

D006302;D012107

T062;T096;T170;T081;T169

36,329,422

circul endocannabinoid level pregnant women gestat diabet mellitus case control studi role endocannabinoid ec insulin resist associ viscer obes metabol profil studi extens sinc associ ec metabol factor gestat diabet mellitus gdm clear aim evalu level n arachidonoylethanolamid aea arachidonoylglycerol ag associ c reactiv protein crp glycem indic blood pressur anthropometr indic pregnant women gdm

D016640

T047

36,329,421

operation assent research particip pre adolesc children scope review seek assent children particip medic research ethic imper numer institut global howev none organ provid specif guidanc criteria process use obtain assent primari object scope review determin descript assent discuss literatur report criteria use seek assent research particip pre adolesc children

D007258;D035843

T089;T062

36,329,420

subtot gastrectomi pancreaticoduodenectomi versus convent pancreaticoduodenectomi incid delay gastric empti singl center retrospect cohort studi delay gastric empti dge one common complic pancreaticoduodenectomi pd current wide accept procedur pd reduc incid dge institut attempt perform subtot gastrectomi patient undergo pd reduc dge aim evalu effect safeti pd subtot gastric resect

D016577;D018589

T061;T047

36,329,419

associ mirna mirna express peripher blood mononuclear cell patient multipl sclerosi case control studi microrna mir mirna short regulatori rnas modul post transcript gene express dysregul molecul contribut pathogen autoimmun disord multipl sclerosi ms

D009103;D020529;D035683

T123;T047;T114

36,329,418

valosin contain protein aspg mutat patient frontotempor dementia case report variant valosin contain protein vcp gene identifi one caus inclus bodi myopathi associ paget diseas bone frontotempor dementia ftd previous identifi pathogen variant vcp associ frontotempor lobar degener tdp inclus ftld tdp patholog paspg vcp recent report caus famili ftd tauopathi character neurofibrillari tau tangl nft ftld tdp describ clinic genet find patient paspg valosin contain protein vcp diagnos ftd without famili histori absenc muscl bone diseas comorbid

D057180;D057174;D001847

T047;T048

36,329,417

addit cone beam ct panor imag reduc inferior dental nerv injuri result third molar surgeri systemat review systemat review aim examin whether cone beam ct cbct assess influenc incid nerv injuri follow high risk mandibular third molar mtm surgeri

D008964;D014081

T061;T023

36,329,416

optic coher tomographi angiographi analysi microvascular abnorm vessel densiti treatment nave eye diabet macular edema aim studi evalu structur retin vascular integr use optic coher tomographi angiographi octa treatment nave eye diabet macular edema dme compar find diabet eye without dme

D003930;D008269;D000071071;D003920

T047;T046;T190

36,329,415

associ impuls hyperact inattent nonsuicid self injuri suicid behavior longitudin cohort studi follow children risk neurodevelopment disord mid adolesc knowledg separ attent deficithyperact disord adhd subdimens impuls hyperact inattent associ nonsuicid self injuri nssi suicid behavior sb limit object studi investig associ childhood adhd subdimens nssi sb children risk neurodevelopment disord ndds includ adhd

D016728;D001289

T055;T048

36,329,414

valu nurs led anthropometr oropharyng measur combin stop bang questionnair screen obstruct sleep apnea patient acut coronari syndrom prospect cohort studi obstruct sleep apnea osa modifi risk factor acut coronari syndrom ac high preval low diagnost rate therefor particular import develop strategi better screen osa newli admit ac patient

D054058;D008844;D020181

T019;T047

36,329,413

share compon model earli childhood anaemia malaria kenya malawi tanzania uganda malaria anaemia contribut substanti child morbid mortal studi sought joint model residu spatial variat likelihood two correl diseas control individu level household level environment characterist

D008288;D000740

T047

36,329,412

advanc limit treatment spinal muscular atrophi spinal muscular atrophi q sma sma genet neuromuscular condit affect spinal motor neuron caus defect copi smn gene produc surviv motor neuron smn protein high homolog smn gene primarili express rapid degrad isoform smn protein caus anterior horn cell degener progress motor neuron loss skelet muscl atrophi weak sever case result limit mobil ventilatori insuffici untreat sma lead genet caus death young children recent three therapeut increas smn protein level patient sma provid increment improv motor function development mileston prevent worsen sma symptom therapeut approach spinraza zolgensma evrysdi clinic signific impact curat mani patient remain signific diseas burden potenti combin therapi develop sma target myostatin negat regul muscl mass strength myostatin inhibit anim model increas muscl mass function apitegromab investig fulli human monoclon antibodi specif bind proform myostatin promyostatin latent myostatin therebi inhibit myostatin activ recent complet phase trial demonstr potenti clinic benefit apitegromab improv stabil motor function patient type type sma provid posit proof concept myostatin inhibit target manag sma primari goal manuscript orient physician evolv landscap sma treatment

D009134;D055435

T123;T047;T116

36,329,411

associ preterm birth socioeconom develop analysi nation data increas preval preterm birth global phenomenon attribut increas medic indic artifici gestat socioeconom factor studi conduct identifi whether develop equal indic associ incid preterm birth specif spontan elect preterm birth

D047928

T046

36,329,410

refuge healthcar need barrier access healthcar servic new zealand qualit phenomenolog approach refug asylum seeker specif healthcar need howev insuffici attent effort address need global furthermor effect communic healthcar provid refuge remain poor widen imbalanc power dynam aim research project examin refuge healthcar need current barrier access healthcar servic new zealand propos solut explor percept attitud belief opinion key stakehold regard refuge healthcar need within scaffold health social care system

D012036

T098

36,329,409

global abund short tandem repeat non random rodent primat predomin abund across vertebr genom signific biolog implic relev short tandem repeat strs also known microsatellit speciat remain larg elus attribut random coincid part collect data whole genom abund mono di trinucleotid strs nine speci encompass rodent primat includ rat mous oliv baboon gelada macaqu gorilla chimpanze bonobo human collect data use analyz hierarch cluster str abund select speci

D012377;D006071

T015

36,329,408

two dimension speckl track echocardiographi demonstr improv myocardi function intraven infus bone marrow mesenchym stem x link muscular dystrophi mice bone marrow mesenchym stem cell bmscs common use regen medicin howev clear whether transplant bmscs improv cardiac function x link muscular dystrophi mice mdx detect aim investig role speckl track echocardiographi ste detect cardiac function bmscs transplant mdx comparison untreat mdx

D001853;D020388

T023;T024;T047

36,329,407

chang work condit job relat challeng due sar cov pandem medic assist general practic germani qualit studi germani general practic usual contact first patient health complaint includ symptom characterist sar cov within general practic medic assist mas first contact person patient perform various task close physic patient contact work condit mas character challeng eg due low salari high workload time pressur frequent interrupt potenti chang work condit job relat challeng experienc mas due sar cov pandem fulli explor aim address knowledg gap among mas work general practic germani

D000086402;D000086382

T005;T067;T047

36,329,406

novel method drug target interact predict base graph transform model drug target interact dtis predict becom import acceler drug research drug reposit drug target interact network typic model dtis predict mani differ type relationship exist drug target drug target interact network use model drug target interact relationship recent work drug target interact network most concentr drug node target node neglect relationship drug target

D000465;D000076722

T062;T170;T091

36,329,405

identif key cuproptosi relat gene target patient igan iga nephropathi igan one common form chronic glomerulonephr aetiolog pathogenesi remain unclear cuproptosi newli identifi form cell death play import role mani diseas research clear determin whether express cuproptosi relat gene crgs involv pathogenesi igan

D005922

T047

36,329,404

neonat lupus present neonat hemochromatosi like liver diseas respond steroid case report neonat lupus erythematosus rare multisystem autoimmun disord predomin involv heart congenit heart block involv organ includ liver diseas result passag matern autoantibodi fetus manifest various form depend organ involv neonat lupus liver diseas manifest rang benign elev aminotransferas fatal hepat insuffici iron deposit respond therapi hand case report date antibodi implic sjogren syndrom type b antibodi non specif autoantibodi posit well antinuclear antibodi smooth muscl antibodi classic consid specif autoimmun hepat describ chronic liver diseas describ neonat lupus liver diseas herein report rare case neonat cholestasi due neonat lupus liver diseas present posit smooth muscl antibodi addit biochem pictur neonat hemochromatosi remark elev ferritin respond well steroid therapi

D012859;D008180;D007565;D002779;D006505

T184;T047

36,329,403

complet mitochondri genom updat diverg time two freshwat clupeid endem lake tanganyika africa suggest intralacustrin speciat hydrogeolog histori lake tanganyika paint complex imag sever colon adapt radiat event initi basin form around million year ago mya predecessor malagarasi congo river mya sub basin fuse produc clear deep water today next well known radiat cichlid fish lake also harbour modest clade two clupeid speci stolothrissa tanganica limnothrissa miodon member pellonulini tribe clupeid fish most occur freshwat colon west central africa period high sea level cenozo consensus phylogenet relationship member pellonulini time colon lake tanganyika clupeid

D054629;D023681

T028;T013

36,329,402

associ dietari inflammatori potenti probabl sarcopenia among communiti dwell older adult cross section studi unlik numer studi concern role dietari inflammatori potenti chronic diseas limit studi focus associ dietari inflammatori potenti handgrip strength hgs probabl sarcopenia ps studi tend explor associ dietari inflammatori potenti ps among older adult tehran

D055948

T047