PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,214,599 | liquefi petroleum gas biomass cook effect birth weight exposur pregnanc household air pollut caus burn solid biomass fuel associ advers health outcom includ low birth weight whether replac biomass cookstov liquefi petroleum gas lpg cookstov would result increas birth weight unclear | D016902;D010578 | T069;T109;T080 |
36,214,596 | luteolin suppress three angiogenesi mode cell interact uveal melanoma vitro uveal melanoma high vascular tumor lack effect system therapi anti angiogenesi drug therapi target endotheli cell depend angiogenesi vasculogen mimicri vm suppli blood tumor independ endotheli cell thus aim explor inhibitori effect luteolin prolifer migrat invas angiogenesi vm activ uveal melanoma explor signal pathway under mechan action luteolin | D051057;D047311 | T121;T109;T126;T116 |
36,214,590 | effect colonoscopi screen risk colorect cancer relat death although colonoscopi wide use screen test detect colorect cancer effect risk colorect cancer relat death unclear | D003113;D015179;D055088;D008403 | T191;T061;T060;T058 |
36,214,586 | communiti base hospit affili medic group becom success account care organ leadership multispecialti group practic within health system recogn popul health manag requir qualiti perform improv organiz cultur chang blueprint build success account care organ aco exist literatur describ journey achiev share save high qualiti outcom achiev medic group within academ health system clinician educ engag priorit prevent achiev benchmark develop support role precis document accur diagnost code risk stratif constitut approach first particip aco medic group built program team improv qualiti cms simultan chang qualiti measur pay report pay perform qualiti score initi dip though score sinc risen financi result million threshold perform year northeast medic group achiev million aggreg share save | D060866 | T093 |
36,214,583 | risk factor immun mediat hepatotox patient cancer treat immun checkpoint inhibitor systemat review meta analysi immun checkpoint inhibitor ici effect treatment various cancer lead immun mediat hepatotox imh aim studi analyz risk factor imh cancer patient treat ici | D009369;D064420;D056486 | T191;T047;T046;T037 |
36,214,582 | marker auxiliari differenti diagnosi earli melanoma benign nevi share similar featur potenti lead misdiagnosi review immunohistochem studi although melanocyt skin lesion correct diagnos numer studi shown interobserv disagr review analyz molecul immunohistochem marker distinguish dysplast andor spitz nevi earli melanoma situ clark level ii andor breslow thick mm detect presenc andor level test molecul signific differ earli melanoma dysplast spitz nevi six seven potenti marker respect promis result obtain hydroxymethylcytosin cyclooxygenas preferenti express antigen melanoma whose level differ dysplast spitz nevi compar earli melanoma | D018332;D008545;D012878 | T191 |
36,214,580 | supplement prebiot high esterifi pectin improv blood pressur cardiovascular risk biomark profil counteract metabol malprogram supplement prebiot pectin associ benefici health effect aim character cardioprotect action chronic high esterifi pectin hep supplement model metabol malprogram rat prone obes associ disord progeni mild calori restrict dam first half pregnanc result show pectin supplement revers metabol malprogram associ gestat undernutrit sens hep supplement improv blood pressur reduc heart lipid content regul cardiac gene express atrial natriuret peptid lipid metabol relat gene moreov caus elev circul level fibroblast growth factor higher express co receptor klotho heart effect correl gut level benefici bacteria promot hep therefor chronic hep supplement show cardioprotect action henc worth consid strategi prevent program cardiometabol alter | D056692;D002318 | T047;T109 |
36,214,578 | complet genom sequenc reveal unusu equin rotavirus bat origin india rotavirus common viral agent associ foal diarrhea annual preval rotavirus diarrheic foal rang haryana india whole genom sequenc two equin rotavirus erva isol rvahors wtinderv rvahors wtinderv carri determin genotyp constel gcs erva gcs isol g p r c n e h uniqu combin report erva far isol carri vp genotyp previous unreport equin upon comparison rvas speci gc isol ident bat rotavirus strain mslh isol china nucleotid sequenc gene encod vp nsp nsp share ident bat rva strain isol africa gabon gene encod vp vp vp nsp nsp share nucleotid ident human strain zoonot link bat rch ms vp gene strain distinct highest similar cmh human strain bat origin phylogenet analysi lineag studi reveal vp isol cluster new lineag lineag x g genotyp bat human alpaca strain similar vp cluster distinct p lineag unusu find highlight terra incognita genom divers equin rotavirus support need surveil rvas anim human one health approach import rotavirus global preval diarrheal pathogen young anim includ foal piglet calv goat sheep cat dog along human genom rotavirus consist segment enabl undergo reshuffl reassort segment multipl speci mix infect studi preval equin rotavirus organ equin farm north india complet genom analysi two erva isol reveal unusu genom constel previous report bat rva strain segment wise phylogenet analysi reveal segment isol high similar either bat bat like human rotavirus occurr unusu bat like rotavirus equin emphas need extens surveil complet genom anim human rotavirus one health approach | D012401;D002685;D012400;D002161 | T015;T005;T047 |
36,214,577 | dissect natur aris amino acid substitut posit l sar cov spike mutat spike protein l recurr observ sever acut respiratori syndrom coronavirus sar cov variant concern voc includ omicron lineag remain elus amino acid substitut l select voc character possibl mutat site reveal five mutant express amino acid q k h r gain greater fusogen pseudovirus infect wherea mutant fail maintain steadi state express level andor pseudovirus infect moreov five mutant show decreas sensit toward neutral vaccin induc antisera confer escap cell recognit contrari expect sequenc data retriev global initi share influenza data gisaid reveal natur occur l mutat limit q r aris singl nucleotid chang collect find highlight codon base chang mutat barrier prerequisit amino acid substitut l addit phenotyp advantag viral fit decreas sensit host immun import span less year sinc declar coronavirus pandem numer sar cov variant concern emerg around globe fuel surg number case death caus sever strain health care system major concern whether viral evolut eventu promot greater fit advantag transmiss immun escap studi address differenti effect amino acid substitut frequent mutat site l sar cov spike viral antigen immunolog profil demonstr virus evolv select one amino acid other ensur better viral infect immun evas identifi virus mutat signatur could crucial prepared futur intervent control covid | D000086402;D000086382 | T067;T047;T005 |
36,214,567 | luminesc gold nanoparticl control hydrophob interact construct luminesc gold nanoparticl aunp high redshift emiss second near infrar window nir ii good biocompat still challeng herein use amphiphil block copolym abc templat control hydrophob interact divers form unim micell report facil strategi redshift emiss enhanc biolog interact luminesc aunp uniform cluster nir ii aunp form situ insid hydrophob core abc micell strong interparticl hydrophob interact enhanc emiss nm high quantum yield qy rigid nir ii aunp generat strong intraparticl hydrophob interact abc unim surfac lead redshift emiss nm qy enhanc affin toward injur intestin mucosa coliti imag find open new possibl design high redshift luminesc aunp enhanc biolog interact | D053768;D053758 | T073 |
36,214,547 | visit visit sbp variabl risk atrial fibril middl age older popul sought examin relationship visit visit variabl sbp incid atrial fibril middl age older popul | D001281 | T047;T046 |
36,214,538 | engin electromagnet field distribut reson qualiti factor use slot quasi bic metasurfac dielectr metasurfac govern bound state continuum bic activ investig achiev high qualiti factor strong electromagnet field enhanc tradit approach report tune perform quasi bic metasurfac includ tune reson size period structur symmetri propos experiment demonstr altern approach engin slot within zigzag array ellipt silicon reson analyt theori three dimension electromagnet model infrar spectroscopi systemat investig spectral respons field distribut slot metasurfac mid ir result show introduc slot electr field intens enhanc near apex qualiti factor quasi bic reson increas factor respect comparison metasurfac without slot furthermor slot metasurfac also provid extra region electromagnet enhanc confin hold enorm potenti particl trap sens emiss enhanc | D004574;D012825 | T196;T070 |
36,214,529 | outcom experi use oral voriconazol without concomit topic agent treat refractori vulvovagin yeast infect describ case refractori vulvovagin yeast infect rvvyi treat use oral voriconazol without concomit topic agent | D015725;D002181 | T121;T047;T109 |
36,214,528 | interact hiv mental health modern antiretrovir therapi era peopl hiv pwh receiv effect antiretrovir therapi art continu display residu immun dysregul amplifi risk neuropsychiatr comorbid time pwh common experi intersect stigma psychosoci stressor link neuroendocrin stress respons potenti residu immun dysregul alter biobehavior process relev health outcom special issu psychosomat medicin seek advanc understand intersect hiv mental health modern art era sever articl cover topic relat preval treatment psychiatr comorbid among pwh depress suicid substanc use disord articl delin biobehavior mechan relev mental health pwh inflamm immun activ neuroendocrin signal cellular age microbiom gut brain axi neurobehavior process collect articl special issu highlight continu import biobehavior neurobehavior mental health research modern art era | D015658;D019966 | T047;T048;T033 |
36,214,526 | liquid crystal electro optic transduc electrophysiolog sens applic object biomed instrument clinic system electrophysiolog reli electrod wire sens transmiss bioelectr signal howev electron approach constrain bandwidth signal condit circuit design number channel invas miniatur devic paper demonstr altern approach use light sens transmit electrophysiolog signal approach develop sens passiv fluorophor free optrod base birefring properti liquid crystal lcs oper microscal main result show optrod appropri linear sd n devic relat respons sd v n devic bandwidth sd khz n devic transduc electrophysiolog signal optic domain report captur rabbit cardiac sinoatri electrogram stimulus evok compound action potenti rabbit sciatic nerv also demonstr miniaturis potenti fabric multi optrod array develop process automat match transduc element area correspond biolog interfac signific method employ lcs convert bioelectr signal optic domain pave way deploy high bandwidth optic telecommun techniqu ultra miniatur clinic diagnost research laboratori neural cardiac interfac | D050866 | T104;T073 |
36,214,522 | energi decomposit along reaction coordin theori applic nonequilibrium ensembl trajectori theoret framework propos energi decomposit scheme along reaction coordin ensembl averag potenti energi weight reactiv flux intens decompos energi compon per coordin level decompos energi quantiti demonstr close relat free energi along reaction coordin connect emerg potenti energi provid applic alanin dipeptid vacuum illustr calcul perform three nonequilibrium ensembl trajectori transit path ensembl sampl transit path sampl ensembl short trajectori initi configur around transit state region ensembl short trajectori shoot configur sever transit path energi compon coordin found consist among three ensembl trajectori indic broad applic approach biomolecular studi addit free energi along optim reaction coordin obtain nonequilibrium ensembl larg overlap refer free energi calcul long equilibrium trajectori | D000409;D004151 | T121;T123;T116 |
36,214,512 | accur model bromid iodid hydrat data driven mani bodi potenti ion water interact play central role determin properti aqueous system wide rang environ howev quantit understand hydrat properti ion evolv small aqueous cluster bulk solut interfac remain elus introduc second generat data driven mani bodi energi mb nrg potenti energi function pef repres bromid water iodid water interact mb nrg pef use permut invari polynomi reproduc two bodi three bodi energi calcul coupl cluster level theori implicit repres higher bodi energi use classic mani bodi polar systemat analysi hydrat structur small br h n h n cluster demonstr mb nrg pef predict interact energi quantit agreement gold standard coupl cluster refer valu import use molecular dynam simul carri isotherm isobar ensembl singl bromid iodid ion liquid water mb nrg pef predict extend x ray absorpt fine structur exaf spectra accur reproduc experiment spectra thus allow character hydrat structur two ion high level confid | D001965;D007454 | T197 |
36,214,510 | critic apprais qualiti vertigo practic guidelin use agre ii tool euroaim initi aim review assess methodolog qualiti guidelin manag vertigo dizzi compar recommend specif focus neuroimag | D004244;D014717 | T046;T047;T184;T033 |
36,214,506 | incid manag facial paralysi skull base trauma administr databas studi report incid treatment pattern facial nerv palsi skull base fractur | D005158;D018058;D006259;D034381;D012887 | T047;T184;T037;T033 |
36,214,499 | match cohort studi radiograph superior semicircular canal dehisc tegmen dehisc obstruct sleep apnea report frequenc radiograph superior semicircular canal dehisc sscd tegmen dehisc patient without obstruct sleep apnea osa | D007759;D000084322;D020181 | T047 |
36,214,496 | contamin transfect complex masquerad small extracellular vesicl impair deliveri rna one function small extracellular vesicl sev receiv attent capac deliv rna cytoplasm target cell studi often perform transfect rnas sev produc cell later purifi studi sev deliveri rna transfect complex deliveri vehicl accumul late endosom sev form transfect complex deliveri vehicl administ cell releas extracellular space exocytosi rais possibl transfect complex could alter sev contamin sev prepar found wide use transfect reagent includ rnaimax interferin accumul late endosom transfect complex size similar sev purifi ultracentrifug like sev focus lipid base transfect reagent rnaimax found prepar sev transfect cell contain lipid transfect complex transfect sirna predomin particl densiti transfect complex rather sev suggest transfect complex lipid base rnaimax may frequent contamin sev prepar could account report sev mediat deliveri nucleic acid transfect cell also impair capac sev deliv stabli express sirna suggest transfect cell may alter sev prevent studi endogen capac deliv rna target cell | D000067128 | T026 |
36,214,495 | doubl graft pet fiber materi remov airborn bacteria high effici air pollut caus bacteria virus pose serious threat public health commerci air purifi base dens fibrous filter remov particul matter includ airborn pathogen kill effici develop doubl graft antibacteri fiber materi high effici captur inactiv airborn microorgan tetracarboxyl phthalocyanin zinc photosensit first graft onto polyest pet fiber follow coat chitosan surfac pet fiber make doubl graft fiber materi irradi light specif wavelength nm doubl graft fiber materi kill gram posit bacteria gram negat bacteria signific antibacteri effect drug resist bacteria doubl graft pet fiber show broad spectrum antibacteri activ capabl inactiv drug resist bacteria notabl filtrat experi airborn bacteria doubl graft pet fiber demonstr high bacteria captur effici better untreat pet fiber besid doubl graft pet fiber capabl effici kill airborn bacteria work provid new idea develop air filtrat materi effici kill airborn pathogen good biosafeti | D011091;D048271 | T121;T109;T122 |
36,214,493 | transfect reagent artefact like account report extracellular vesicl function extracellular vesicl ev import mediat cell communic physiolog ev frequent investig transient transfect cell plasmid dna produc ev modifi protein nucleic acid interest dna transfect reagent complex dtc approxim size ev rais possibl purif procedur may fail separ two speci activ aris carryov dtc may improp attribut ev find differenti ultracentrifug common employ ev isol procedur separ ev dtc present cell cultur supernat transient transfect cell demonstr biolog activ ev direct cre recombinas due contamin plasmid dna ev mediat deliveri cre protein moreov step common taken remov plasmid dna ev sampl media exchang treatment nucleas ineffect avoid artefact due pernici natur plasmid dna cellular assay report ev function like artefact produc contamin dtc ev dtc separ densiti gradient ultracentrifug highlight import valid elimin dtc use transient transfect ev produc cell interrog ev function | D000067128;D009696 | T026;T123;T114 |
36,214,484 | optic detect imag nonfluoresc matter singl moleculeparticl level sinc first optic detect singl molecul singl molecul spectroscopi develop rapid wide appli mani area howev vast major matter extrem ineffici emit photon physic world serious limit applic optic method base photoluminesc addit indirect detect fluoresc label mani effort made direct imag nonfluoresc matter singl particl singl molecul level differ way base absorpt scatter interact light matter herein review five popular method imag nonfluoresc particlesmolecul includ dark field microscopi dfm surfac plasmon reson microscopi sprm surfac enhanc raman microscopi serm interferometr scatter microscopi iscat phototherm microscopi ptm summar principl applic method compar advantag disadvantag method describ potenti develop applic | D020845;D036103 | T121;T090;T125 |
36,214,482 | dark side foetal bovin serum extracellular vesicl studi extracellular vesicl ev shown involv cell cell communic take part physiolog patholog process thank exclus cargo includ protein lipid nucleic acid origin cell gain interest potenti biomark diseas recent year appeal featur fascin research world thus increas number vitro studi focus ev releas content biolog activ cultur cell line use sourc ev howev ev releas cell cultur influenc cell cultur condit use foetal bovin serum fbs fbs common supplement cell cultur media also sourc contamin exogen bovin ev rna protein aggreg contamin cell deriv ev influenc cargo composit presenc fbs contamin cell deriv ev sampl well known issu limit clinic applic ev thus increas need standard review discuss pros con use fbs cell cultur sourc ev well protocol use remov contamin fbs | D000067128;D009696 | T026;T123;T114 |
36,214,481 | function character phosphatas involv capsular polysaccharid biosynthesi campylobact jejuni campylobact jejuni gram negat pathogen bacterium found intestin tract chicken mani farm anim c jejuni infect result campylobacteriosi caus nausea diarrhea fever cramp death surfac bacterium coat thick layer sugar known capsular polysaccharid high modifi polysaccharid contain unusu glucuronamid moieti serotyp hs hs previous demonstr phosphoryl glucuronamid intermedi synthes c jejuni nctc serotyp hs cumul reaction three enzym cj cjcj cj cj function udp glucos dehydrogenas make udp glucuron cj cj catalyz format ethanolamin phosphat serinol phosphat respect final cj catalyz amid bond format use glucuron either ethanolamin phosphat serinol phosphat investig final glucuronamid modifi enzym cj cj shown catalyz hydrolysi phosphat ester either glucuronamid ethanolamin phosphat serinol phosphat kinet constant rang substrat determin stereoselect enzym hydrolysi glucuronamid serinol phosphat establish use p nuclear magnet reson spectroscopi bioinformat analysi cj reveal member phosphatas superfamili uniqu dxxe catalyt motif | D016123 | T007 |
36,214,478 | tetraphenylphosphonium chlorid enhanc ionize coupl orbitrap mass spectrometri sensit non target screen polyhalogen alkyl compound limit serum although mani type halogen compound known bioaccumul human routin biomonitor mani remain uncharacter human exposom studi due lack high sensit high resolut analyt method studi discov tetraphenylphosphonium chlorid ph pcl simpl addit mobil phase enhanc ionize polyhalogen alkyl compound organochlorin pesticid ocp chlorin paraffin cps dechloran plus dps bromin flame retard bfrs form cl boost mass spectrometri respons averag order magnitud resolut ph pcl enhanc ionize coupl halogen guid screen process use establish sensit non target method requir singl step sampl prepar identifi cl andor bromin contain alkyl compound method enabl identif polyhalogen compound l human serum known compound short chain cps median chain cps long chain cps short chain cps vsccps ocp dps bfrs also identifi emerg contamin unsatur cps chlorin fatti acid methyl ester cfame chloro bromo alken new contamin oxygen contain cps hexachlorocyclohexan structur analog amino contain nitrat contain chlorin compound full scan result highlight domin cps cfame vsccps dichlorodiphenyltrichloroethan serum sampl ph pcl enhanc ionize enabl sensit non target identif polyhalogen compound small volum biolog fluid | D005411;D006843;D010575 | T109;T131;T120 |
36,214,472 | innov convers pretreat buxus sinica high perform biocomposit potenti use furnitur materi tradit wood base panel usual made larg diamet tree reli adhes compact negat impact environ human health howev wide distribut small diamet shrub good raw materi wood base panel abund fiber often exploit research report prepar self bond biocomposit buxus sinica innov combin approach extract alkali treatment hot mold result biocomposit show better mechan properti flexur modulus gpa tensil modulus gpa time time higher convent fiberboard respect also demonstr better hydrophob fiberboard could due layer lignin form surfac prevent infiltr water sum biocomposit prepar small diamet shrub meet requir furnitur architectur decor materi suggest propos approach use produc high perform biocomposit | D008031;D031235 | T109;T123;T002 |
36,214,468 | real world treatment pattern prognost factor stage iv lung squamous cell carcinoma patient lung squamous cell carcinoma lusc repres minor proport nonsmal cell lung cancer nsclc harbor poor prognosi herein retrospect medic record research perform investig real world treatment pattern identifi prognost factor among lusc patient total patient median age year enrol analysi male predomin n current ex smoker contribut entir cohort pleura lung common metastat site wherea brain metastasi diagnosi howev patient receiv first line chemotherapi chemotherapi cohort median progress free surviv pfs overal surviv os month respect multivari analysi bone metastasi use first line singl agent chemotherapi independ predict shorter pfs baselin characterist male sex metastasi lung pleura liver bone independ predict wors os regard treatment pattern patient undergon standard first line doublet therapi employ target therapi diseas progress link longer os real world even underw chemotherapi still poor outcom find may help clinician orchestr treatment strategi lusc patient provid direct larg scale studi | D002289;D002294;D008175 | T191 |
36,214,454 | evolutionari rescu phosphomannomutas defici yeast model human diseas common caus human congenit disord glycosyl cdg mutat phosphomannomutas gene pmm affect protein n link glycosyl yeast gene sec encod homolog human pmm evolv popul yeast harbor one two human diseas associ allel sec vm sec fl wild type sec find generat popul compens slow growth phenotyp associ sec human diseas associ allel whole genom sequenc identifi compensatori mutat includ known sec genet interactor observ enrich compensatori mutat gene whose human homolog associ type cdg includ pgm encod minor isoform phosphoglucomutas yeast genet reconstruct show evolv pgm mutat domin allel specif genet interactor restor protein glycosyl growth yeast harbor sec vm allel final character enzymat activ purifi pgm mutant protein find reduct elimin pgm activ best compens deleteri phenotyp associ sec vm allel broad result demonstr power experiment evolut tool identifi gene pathway compens human diseas associ allel | D018981;D029701 | T047;T116 |
36,214,453 | hyponatremia time incid associ risk factor patient treat cisplatin lung cancer retrospect studi incid cisplatin deriv hyponatremia remain unknown although nausea vomit renal dysfunct common advers event cisplatin platinum base prepar factor contribut hyponatremia describ well known studi aim retrospect investig incid hyponatremia time associ risk factor studi survey patient lung cancer receiv cisplatin chemotherapi august juli shizuoka cancer center sever hyponatremia evalu base common terminolog criteria advers event total patient includ studi patient hyponatremia grade grade mmoll grade mmoll grade mmoll hyponatremia observ patient respect patient grade hyponatremia develop first treatment cycl multivari analysi short hydrat regimen ml hydrat regimen p addit na valu start administr mmoll incid grade hyponatremia higher p hyponatremia due cisplatin like occur patient low na level administr elder sinc short hydrat might avoid diuret hydrat method might need reconsid prevent hyponatremia | D007010;D008175 | T191;T047 |
36,214,452 | develop versatil high throughput mutagenesi assay multiplex short read ngs use dna barcod supf shuttl vector librari amplifi e coli forward mutagenesi assay use supf gene wide employ last sever decad studi address mutat frequenc mutat spectra associ various intrins environment mutagen studi use supf shuttl vector non sos induc escherichia coli short read next generat sequenc ngs technolog present advanc method studi mutat simpl versatil cost effect demonstr perform newli develop assay via pilot experi ultraviolet uv irradi result emerg relev expect ngs data obtain sampl indic e coli grown titer plate provid mutat frequenc spectrum data uncov obscur mutat detect convent supf assay furthermor small amount ngs data select plate reveal almost full spectrum mutat specimen offer us novel insight mechan mutagenesi despit consid alreadi well known believ method present contribut futur opportun research mutagenesi dna repair cancer | D004926;D005822 | T007;T114 |
36,214,451 | transient regul focal adhes via tensin requir nascent oligodendrocyt differenti differenti oligodendroglia oligodendrocyt precursor cell opc complex extens myelin oligodendrocyt ol multistep process involv larg scale morpholog chang signific strain cytoskeleton key chromatin transcript regul differenti identifi target gene respons morpholog chang occur ol myelin still larg unknown show regul focal adhes tensin tns direct target gene olig chd chd transcript regul ol differenti tns transient upregul local cell process immatur ol togeth integrin key mediat surviv transient stage constitut tns loss function lead reduc viabil mous human surviv knockout mice still express tns oligodendroglia acut delet tns vivo either postnat neural stem cell nscs opc lead twofold reduct ol number find transient upregul tns requir protect differenti opc immatur ol cell death prevent upregul p key regul apoptosi altogeth find reveal specif time window transcript upregul tns immatur ol requir ol differenti like mediat integrin surviv signal actin cytoskeleton ol undergo larg morpholog chang requir termin differenti | D022001;D016159 | T026;T123;T116 |
36,214,449 | landscap transcript translat chang year bacteri adapt organ adapt environ take multipl mutat path redund genet level mani mutat similar phenotyp fit effect make untangl molecular mechan complex adapt difficult use escherichia coli long term evolut experi ltee model address challeng understand differ genom chang could lead parallel fit gain character landscap transcript translat chang across replic popul evolv parallel generat quantifi absolut chang mrna abund show evolv line mrnas increas mrna abund scale cell size also find despit share mutat genet level clone replic popul ltee remark similar gene express pattern transcript translat level furthermor show major express chang due chang transcript level translat chang final show mutat transcript regul lead consist parallel chang express level downstream gene result deepen understand molecular mechan under complex adapt provid insight repeat evolut | D004926;D029968 | T007;T116 |
36,214,448 | decod igf signal gene regulatori network behind alveologenesi mous model bronchopulmonari dysplasia lung develop precis control under gene regulatori network grn disrupt gene network interrupt normal develop caus diseas bronchopulmonari dysplasia bpd chronic lung diseas preterm infant morbid sometim lethal consequ character lung immatur reduc alveolar generat transgen mous exhibit moder sever bpd phenotyp block igf signal secondari crest myofibroblast scmf onset alveologenesi use approach mirror construct model grn sea urchin develop construct igf signal network under alveologenesi use mous model phenocopi bpd construct grn consist gene provid bird eye view gene downstream igf regulatorili connect grn also reveal mechanist interpret effect igf signal transduc within scmf specif gene effector gene scmf neighbor alveolar epitheli cell wnta fgf signal bridg consist block wnta signal mice phenocopi bpd infer network compar studi human sampl suggest grn similar compon wire under human bpd network view alveologenesi transform perspect understand treat bpd new perspect call construct full signal grn under alveologenesi upon target therapi neonat chronic lung diseas viabli develop | D001997 | T047 |
36,214,447 | character intern transcrib spacer apic membran antigen sequenc provid insight genet divers eimeria tenella strain coccidiosi major recur problem poultri industri caus infect one seven eimeria speci known infect chicken eimeria tenella among best studi econom import studi genet divers e tenella strain essenti develop univers accept diagnost marker vaccin diseas eimeria tenella intern transcrib spacer apic membran antigen ama sequenc differ part world avail public domain therefor provid suitabl compar marker genet divers studi studi ama sequenc divers two local e tenella strain name etnsn etsgr character ama sequenc etnsn etsgr retriev map respect genom sequenc generat use next generat sequenc multipl sequenc align ama sequenc select homolog sequenc reveal presenc total five singl nucleotid polymorph snps respect snps appear occur random show uniqu pattern base geograph region insert delet indel found occur align sequenc howev uniqu base defin certain strain detect phylogenet analys perform maximum parsimoni mp maximum likelihood ml method reveal similar topolog intern group e tenella ama sequenc group clade support high bootstrap confid confirm etnsn etsgr sampl e tenella strain sequenc comparison phylogenet analys suggest possibl low genet divers among e tenella strain | D003048;D004539;D016786;D011201 | T047;T204 |
36,214,446 | synthesi character anti mycobacteri activ silico studi new disubstitut oxadiazol deriv seri new disubstitut oxadiazol deriv j j design synthes four step sixteen compound among twenti compound report first time compound character confirm ftir nmr hrms analys test mycobacterium smegmati mycobacterium tuberculosi hra compound activ smegmati mic valu exhibit cidal activ mbc respect time kill assay show good kill rate combin isoniazid inh addit checkboard assay confirm interact compound categoris addit dock simul perform posit pantothen synthetas activ site bind free energi valu kcal mol also occupi activ site standard nativ ligand similar interact clear indic potenti pantothen synthetas inhibitor | D007538;D009169 | T121;T007;T109 |
36,214,445 | efficaci safeti praziquantel treatment neurocysticercosi vietnam neurocysticercosi ncc parasit infect nervous system respons consider morbid mortal praziquantel pzq one antiparasit most use manag ncc howev studi treatment outcom drug present studi aim evalu efficaci safeti pzq patient ncc sixti patient typic characterist ncc receiv three day cycl pzq interrupt cycl day addit treatment includ antiinflamm steroid antiepilept analges clinic imag studi done baselin six month therapi assess efficaci treatment laboratori evalu done cycl investig laboratori safeti profil six month finish therapi patient clinic improv free symptom rate complet partial resolut cyst brain magnet reson imag respect efficaci therapi associ number cyst differ level aspart aminotransferas alanin aminotransferas urea creatinin treatment conclus praziquantel effect safe treatment patient neurocysticercosi | D000871;D003560;D020019 | T121;T047;T190 |
36,214,444 | investig chigger mite small mammal ruili yunnan provinc china chigger mite arthropod sole vector scrub typhus rodent well small mammal common host chigger mite larva therefor great medic signific studi ecolog chigger mite studi detail analysi chigger mite conduct base field survey data total chigger mite collect host survey site ruili yunnan provinc china among chigger five genera one subfamili identifi schoengastiella ligula domin chigger speci highest infest index preval pm mean intens mi p associ coeffici v ligula gahrliepia radiopunctata posit correl p indic tendenc chigger select coexist host time domin speci leptotrombidium kunmingens ascoschoengastia indica ligula g radiopunctata show aggreg distribut pattern indic distribut chigger among differ host uniform low altitud low latitud appear favor growth reproduct chigger mite p suggest collect mani host sampl possibl futur field investig better understand dynam chigger mite popul primari host | D008924;D008925;D012612;D014324 | T047;T204 |
36,214,443 | descript femal simulium wallacellum tuyens takaoka diptera simuliida philippin simulium wallacellum tuyens takaoka one philippin speci subgenus wallacellum takaoka rare speci pupal antenn sheath row stout spine apex protuber correspond flagellomer femal speci describ first time base specimen mindoro philippin character elong sensori vesicl triangular ovipositor valv genit fork two project paraproct produc anterior speci morpholog indistinguish femal male pupa w yonakuniens takaoka yonakuni island japan lanyu island taiwan taxonom note femal speci relev relat speci provid collect data valid earlier distribut record w tuyens w suyoens takaoka mindanao present | D012843 | T204 |
36,214,442 | retrospect preval associ risk factor mycoplasma haemof infect own cat data preval associ risk factor natur occur haemoplasmosi own cat malaysia limit pathogen three known felin haemoplasma speci mycoplasma haemof mhf infect analys determin period preval associ risk factor northeastern malaysia kelantan archiv patient data clinic ill cat suspect haemof infect review studi suspect case clinic diagnos haemoplasmosi amongst subpopul confirm polymeras chain reaction pcr risk factor haemof infect age breed ectoparasit household condit roam status sex analys signific associ breed ectoparasit household condit number cat occurr clinic sign felin mycoplasmosi young male roamer cat like diagnos mycoplasmosi categori cat studi also signific associ cat infect candidatus mycoplasma haemominutum haemof thus coinfect two haemoplasma speci uncommon studi indic infect haemof anaem cat common find client own cat northeastern malaysia natur mode transmiss haemoplasma infect remain unestablish inform studi may highlight import diseas contribut effect prevent control strategi minim felin infecti anaemia fia caus haemof | D000740;D002371;D009174;D009175 | T007;T047 |
36,214,441 | advanc studi molecular identif technolog echinococcus speci larva echinococcus hydatidcyst parasit human anim caus serious zoonot diseas echinococcosi life histori echinococcus complic diseas progress slowli infect earli diagnosi difficult establish due limit imag immunolog diagnosi respect domest foreign scholar establish varieti molecular detect techniqu pathogen echinococcus recent year main includ nest polymeras chain reaction pcr multiplex pcr real time quantit pcr nucleic acid isotherm amplif technolog articl research progress molecular detect technolog echinococcus infect current review signific method detect diagnosi hydatid hydatid diseas also discuss | D004443;D004446;D009696 | T047;T123;T114;T204 |
36,214,440 | gastrointestin manifest covid updat systemat review lack knowledg type preval gastrointestin symptom clinic manifest one reason delay diagnosi treatment covid patient review studi aim systemat review type preval gastrointestin symptom covid patient studi gastrointestin manifest covid use prisma regist camarad ncrs preclin systemat review meta analysi facil syrf databas pubm embas web scienc googl scholar scopus databas search public gastrointestin manifest covid public time frame articl found use follow term search strategi covid coronavirus ncov clinic symptomsgastrointestin gastric intestin manifest paper paper total covid patient met inclus criteria remark articl paper china common gastrointestin manifest nausea vomit diarrhea anorexia abdomin pain respect find present review reveal contrari initi assum covid outbreak infect manifest respiratori symptom also gastrointestin symptom therefor clinician gastroenterologist must alert unusu case fecal oral transmiss covid pandem implement prevent strategi | D000086382;D005767 | T047;T067 |
36,214,439 | polymorph pycrt pvmdr gene plasmodium vivax associ better prognosi malaria earli molecular identif strain plasmodium vivax wors prognosi import stratifi risk complic choic conduct made medic team thus aim present studi associ presenc polymorph pvmdr pvcrt resist gene p vivax patient better wors prognosi cross section epidemiolog studi conduct base data obtain record patient diagnos malaria brazilian amazon tm fl mutat pvmdr gene frequenc respect primo infect patient time greater chanc infect protozoa tm mutat compar patient previous episod regard pvcrt ct tc polymorph frequenc respect self declar white patient time greater chanc infect protozoa ct polymorph addit patient pvcrt polymorph lower concentr c reactiv protein indic better prognosi data present clue genet indic use assess virul parasit prognosi patient vivax malaria | D000962;D016780 | T121;T047 |
36,214,438 | stachi lavandulifolia vahl exhibit promis vitro vivo antileishmani activ leishmania major infect studi aim consid vitro vivo effect stachi lavandulifolia methanol extract slme gml leishmania major infect vitro antileishmani effect slme studi promastigot amastigot form l major effect slme nitric oxid apoptosi secret th cytokin infect rate macrophag cell also studi cytotox slme human thp murin j cell macrophag cell investig measur cytotox concentr cc moreov vivo effect slme heal cutan leishmaniasi cl lesion infect balbc mice studi assess lesion size parasit load four week treatment calcul inhibitori concentr ic valuesfor slme meglumin antimoni promastigot stage gml respect amastigot stage ic valu slme gml gml respect follow day topic therapi slme dose mgkgday cl lesion size well parasit load signific p reduc recoveri percentag infect mice treatment slme dose mgkg respect slme also mark induc product apoptosi wherea decreas infect rate macrophag cell incub infect macrophag slme level interferon gamma meaning p elev dose depend respons contrast releas interleukin il il mark p slme confirm specif amastigot low toxic macrophag result show potent effect slme elimin control leishmania parasit vitro vivo assay base current experiment studi slme suggest altern medicin isol product new agent treat cl caus l major although found cellular mechan slme leishmania parasit addit survey necessari specifi accur mechan action toxic efficaci main human subject | D000981;D018320;D016773;D031366 | T121;T047;T002;T204 |
36,214,437 | higher efficaci singl dosag albendazol differ soil transmit helminth infect profil amongst indigen negrito inland jungl versus resettl town peripheri demargin initi resettl program sinc inevit progress face indigen orang asli oa popul peninsular malaysia malaysian huntergather negrito expos various environment cultur variat chang may influenc pattern soil transmit helminth sth infect common maladi amongst oa studi evalu deworm effect singl dosag albendazol mg sth reinfect rate negrito still live inland jungl versus live resettl town peripheri rps stool sampl consent particip first examin use direct faecal smear formalin ether sediment kato katz techniqu subsequ stool collect carri three time point follow treatment ie day month month brief total number negrito inland rps complet set stool collect includ longitudin studi studi reveal cure rate trichiura inland rps although efficaci albendazol trichiura ultim low rps egg reduct rate err arithmet mean note p lumbricoid hookworm high cure rate found communiti reinfect trichiura seen less month higher rate rps oppos inland day follow treatment studi found inland oa better toler singl dosag albendazol experienc slower sth reinfect rate versus rps henc select albendazol dosag target use singl dosag albendazol biannual would suitabl inland oa convers propos use day albendazol regimen resettl rps popul | D000871;D006373;D006376 | T121;T047;T204 |
36,214,436 | silico structur model qualiti assess plasmodium knowlesi apic membran antigen use compar protein model plasmodium knowlesi common zoonot parasit associ human malaria infect malaysia apic membran antigen ama protein parasit play critic role parasit invas host cell date complet three dimension ectodomain structur p knowlesi ama pkama protein knowledg protein structur import understand protein molecular function three silico server respect structur predict method use studi ie swiss model homolog model phyre protein thread templat base model tasser templat free ab initio model two queri sequenc use studi ie nativ ectodomain pkama strain h protein design pkama h modifi pkama mpkama protein sequenc adapt pichia pastori express qualiti model assess prosa web qmean save v errat verifyd ramachandran plot server generat model superimpos two model plasmodium ama deposit protein data bank pdb ie pkama uvb plasmodium vivax ama pvama w protein structur similar assess quantifi root meansquar deviat rmsd valu swiss model phyre tasser server generat two one five model respect model good qualiti accord prosa web assess base averag valu model qualiti assess superimposit model record highest valu paramet select best predict model ie model pkama h mpkama swiss model well model pkama h model mpkama tasser templat base method use known templat avail templat free method suitabl known avail templat generat model use guidanc protein studi requir protein structur data ie protein protein interact studi | D008288;D016790 | T047;T204 |
36,214,435 | medicin plant antimalari activ mediat via glycogen synthas kinas beta gsk inhibit mani therapeut effect plant extract bioactiv compound appear relat immunomodulatori effect impact host immun system immun respons desir mitig establish infect case sever malaria feasibl approach deal overwhelm cytokin respons glycogen synthas kinas gsk serthr kinas central regul cytokin respons promis antimalari drug target review discuss ongo research project includ assess antimalari activ medicin plant bioactiv compound immunomodulatori activ mediat gsk potenti inflammatori pathway involv malari infect | D000962;D008288;D010946 | T121;T047;T002 |
36,214,434 | distribut model aed aegypti three dengu endem area sumatera indonesia ae aegypti dengu virus vector public health threat indonesia furthermor dengu haemorag fever dhf spread citi countri includ bandar lampung speci distribut model maximum entropi maxent use predict geograph distribut vector three dengu endem area name sukaram kemil tanjung seneng previous surveil conduct determin presenc ae aegypti therefor studi suggest environment variabl rainfal temperatur land cover popul densiti influenc widespread ae aegypti facilit prolifer studi area influenc environment variabl analyz use respons curv model perform measur percent contribut import permut jackknif test studi evalu indic certainti model presenc ae aegypti sukaram kemil tanjung seneng develop extrem well respect valu result show ae aegypti widespread three endem area high popul densiti land convers settlement influenti environment variabl essenti determin distribut vector three area bandar lampung climat factor rainfal temperatur support aspect maintain habitat ae aegypti area map area risk dengu vector aid plan diseas manag strategi identifi prioriti locat entomolog survey control epidem | D000330;D003715 | T047;T204 |
36,214,433 | blastocysti captiv free rang wild anim worldwid review blastocysti preval eukaryot gastrointestin symbiont found human anim worldwid increas human infect rate associ rais concern involv parasit public health last decad number link epidemiolog studi prudent grown microscopi use detect presenc protozoan advent molecular techniqu made detect easier howev due limit host specif zoonot potenti anim either livestock wildlif anim may serv potenti reservoir blastocysti infect transmiss approach utilis studi aid understand distribut preval blastocysti anim particular captiv free rang wild anim worldwid due increas interest review help comprehend epidemiolog aspect demograph subtyp zoonot potenti blastocysti wildlif captiv anim | D016844;D016776 | T047;T204 |
36,214,432 | descript male simulium gomphostilbia miblosi takaoka g apoens takaoka diptera simuliida mindanao philippin male simulium gomphostilbia miblosi takaoka epistum speci group g apoens takaoka ceylonicum speci group mindanao philippin describ first time male g miblosi character hind tibia yellowish white basal three fifth elong calcipala time long basal width ventral plate triangular ventral time high greatest width view caudal tubercl fron trichom head thorax pupa speci illustr first time male g apoens character small sensori vesicl time long third palpal segment enlarg hind basitarsus time wide hind tibia femur respect taxonom note two speci relev relat speci speci group given | D012843 | T204 |
36,214,431 | serolog review bartonella hensela bartonella quintana infect among malaysian patient unknown caus febril ill limit inform avail human exposur bartonella infect ie bartonella hensela causat agent cat scratch diseas bartonella quintana causat agent trench fever west malaysia studi report review serolog find obtain patient attend teach hospit klang valley malaysia indirect immunofluoresc assay ifa use determin igg igm antibodi titer b hensela b quintana pilot studi conduct igg antibodi bartonella spp either b quintana b hensela detect patient clinic suspect rickettsi infect igm antibodi detect patient prompt us investig serolog respons patient clinic suspect febril caus besid rickettsi infect serum sampl analys follow investig bartonella igg antibodi detect patient patient clinic suspect rickettsi infect n dengu n respect none sera obtain leptospirosi n legionellosi n mycoplasma infect n group seroposit bartonella spp review bartonella serolog find studi highlight bartonella infect uncommon consid one caus febril ill malaysia | D001474;D018416;D014205 | T007;T047 |
36,214,430 | evalu antitrypanosom properti apoptot effect ochrolifuanin dyera costulata miq hookf trypanosoma brucei brucei trypanosoma brucei parasit flagel kinetoplastid protozoan respons human african trypanosomiasi hat current chemotherapi drug number side effect drug resist emerg major issu current treatment activ bisindol alkaloid compound ochrolifuanin previous isol leav dyera costulata vitro antitrypanosom activ ochrolifuanin trypanosoma brucei brucei strain bs show strong activ ic valu gml compar effect ochrolifuanin refer compound staurosporin b brucei apoptosi apoptosi induc activ ochrolifuanin evalu use tunel assay cell cycl analysi trypanosoma brucei brucei shown undergo apoptot cell death demonstr appear sever conic hallmark apoptosi ochrolifuanin found induc apoptosi parasit dose time depend manner cell cycl studi reveal gml ochrolifuanin arrest growth b brucei two differ growth phase g g phase concentr gml arrest gm phase conclus result indic ochrolifuanin display antitrypanosom effect b brucei induc apoptosi cell death caus arrest parasit cell differ growth phase result suggest ochrolifuanin may promis lead compound develop new chemotherapi african trypanosomiasi | D029062;D014344;D014346;D014353 | T121;T047;T002;T204 |
36,214,429 | immunochem studi toxocara cani proteas proteas nematod play crucial role larval molt addit activ role egg hatch proteas also consid crucial factor tissu invas connect tissu remodel toxocara cani proteas play import role throughout complex life cycl degrad compon model extracellular matrix basement membran differ physiolog substrat present studi measur proteolyt activ perivitellin fluid pf surround toxocara cani embryo differ stage develop hatch fluid hf surround infect larva well excretori secretori es product larva cultur media perform measur made use casein substrat follow sigma non specif proteas activ assay result show enzym activ increas embryo matur infect larva found continu produc proteas surround hf es product vitro cultiv indic toxocara cani proteas might import worm egg host optim enzymat activ found ph incub antiserum infect mice hf es product decreas proteolyt activ suggest may link proteas present fluid immun respons | D017166 | T204 |
36,214,428 | evalu vitro antifung effect synthet herbal mouth rins oral candida albican candida glabrata mouth rins function breath freshen medica antisept also deliv oral therapeut agent studi evalu compar antifung effect synthet herbal mouth rins oral c albican c glabrata via disk diffus minim inhibit concentr mic minimum fungicid concentr mfc time kill assay growth profil test four chemic mouth rins name brand brand b brand h c brand b use studi show posit antifung activ two speci averag diamet inhibit zone obtain disk diffus test higher mouth rins b c albican mm c glabrata mm compar c candida speci exhibit similar mic mfc valu rang gml gml respect synthet mouth rins effici kill activ elimin grow popul candida spp follow second exposur time analys growth profil curv show mouth rins b result rapid growth deplet candida spp meanwhil three herbal mouth rins name brand e brand c f brand p g less effect c albican c glabrata mouth rins b contain cetylpyridinium chlorid chlorhexidin respect could effect altern control prevent oral candidiasi | D000891;D002176 | T121;T004 |
36,214,417 | mssbauer base molecular level decomposit saccharomyc cerevisia ironom preliminari character isol nuclei one hundr protein saccharomyc cerevisia known contain iron protein found main mitochondria cytosol nuclei endoplasm reticula vacuol cell also contain non proteinac low molecular mass labil iron pool lfep molecular iron speci interact cellular system level underdevelop would requir consid entir iron content cell ironom paper mssbauer mb spectroscopi use probe ironom yeast mb spectra whole cell isol organell predict sum spectral contribut iron contain speci cell simul requir input publish proteom microscopi data well previous spectroscop redox character individu iron contain protein composit simul compar experiment determin spectra simul mb spectra non proteinac iron pool cell assum account major differ simul experiment spectra whole cell isol mitochondria vacuol nuclei predict contain iron most form fes cluster experiment confirm isol nuclei fe enrich cell obtain first mb spectra organell studi provid first semi quantit estim concentr iron contain protein non proteinac speci yeast well novel approach spectroscop character lfep | D012441;D029701 | T116;T004 |
36,214,413 | dendrim sirna conjug target intracellular deliveri glioblastoma anim model small interf rnas sirna potent weapon gene silenc opportun correct defect gene stop product undesir protein mani applic central nervous system cns disord howev success deliveri sirna brain parenchyma face obstacl blood brain barrier bbb brain tissu penetr target specif cell addit sirna unstabl physiolog condit suscept protein bind enzymat degrad necessit higher dosag remain effect address issu advanc sirna deliveri report develop coval conjug hydroxyl termin poli amidoamin pamam dendrim sirna conjug demonstr sirna gfp sigfp conjug sigfp util glutathion sensit linker allow precis nucleic acid load protect payload prematur degrad deliv sirna cargo cell achiev signific gfp knockdown vitro vivo compar commerci avail deliveri system rnai max lipofectamin sigfp retain potenc sirna vitro addit dendrim sigfp conjug signific enhanc half life sirna presenc plasma endonucleas maintain passiv target abil pamam dendrim reactiv microglia administ intratumor orthotop glioblastoma multiform tumor gbm cxcr gfp mice sigfp local tumor associ macrophag tam within tumor parenchyma minim target effect cell popul facil conjug strategi dendrim sirna conjug present offer promis approach target system intracellular deliveri sirna serv potenti bridg clinic translat rnai therapi | D005909;D050091 | T191;T104;T122 |
36,214,410 | approach benchmark character vitro human model system vitro human model gastruloid organoid complex three dimension structur often consist cell multipl germ layer possess attribut develop embryo organ use model interrog human develop organogenesi model must accur recapitul aspect vivo counterpart recent advanc singl cell technolog includ sequenc spatial approach enabl effort better understand direct compar organoid nativ tissu exampl singl cell genom effort creat cell organ atlas enabl benchmark vitro model also leverag gain novel biolog insight use improv vitro model spotlight discuss state current vitro model system effort creat larg public avail atlas develop human data use improv organoid limit perspect futur effort also discuss | D019985;D009940 | T024;T081 |
36,214,409 | zinc traffick apo zn protein cellular interplay proteom metallothionein glutathion recent studi investig impact glutathion gsh transfer zinc zn proteom apo carbon anhydras probe requir glutathion zinc traffick llc pk pig kidney epitheli cell deplet gsh least left cell viabl abl divid synthes zn protein control rate h period loss gsh stimul accumul x normal concentr cellular zn accord gel filtrat chromatographi differenti centrifug filtrat spectrofluorimetri tsq extra zn distribut proteom metallothionein mt test function proteom andor mt sourc zn constitut zn protein gsh defici cell incub caedta isol normal sourc nutrient zn control cell plus caedta stop divid gsh deplet cell plus caedta continu divid rate gsh defici cell evid proteom andor mt serv function sourc zn generat zn protein vitro insert zn bound proteom apo carbon anhydras occur faster larger concentr zn bound proteom result support hypothesi enhanc transport zn cell drive convers apo zn protein zn protein mass action similar result also obtain human jurkat lymphocyt epitheli cell studi reveal power new model studi chemistri zn traffick includ transport process involv intermedi bind site constitut zn protein | D008668;D002256 | T126;T123;T116 |
36,214,407 | safeti evalu novel algal feed addit poultri product feed addit critic compon poultri health econom viabil antibiot free poultri product aim present studi evalu safeti novel algal deriv feed addit dri biomass powder produc chlamydomona reinhardtii strain cral modifi express n acetylmuramoyl l alanin amidas ec lysozym type enzym ec day oral toxic studi show cral dri biomass powder fulli toler broiler chicken base lack detriment effect found perform mortal hematolog blood clinic chemistri histopatholog result compar nontreat control group result observ advers effect level ppm highest dose test studi demonstr first ever safeti result c reinhardtii microalga dri biomass powder use feed addit broiler chicken furthermor safeti shown two addit enzym express within c reinhardtii cral strain ingest bird | D002645;D011200 | T012 |
36,214,406 | ornithobacterium rhinotracheal isol turkey year period harbor similar antimicrobi suscept profil multidrug resist infect ornithobacterium rhinotracheal caus respiratori diseas requir antibiot treatment poultri worldwid field agent known often resist mani antimicrobi complic therapeut intervent therefor clear need monitor trend resist develop present studi antibiot resist profil rhinotracheal strain isol diseas turkey investig antimicrobi substanc microdilut method suscept toward chloramphenicol carbapenem sulfamethozaxol combin found strain isol also suscept penicillin except oxacillin cephalosporin tetracyclin tylosin case quinolon isol show intermedi resist enrofloxacin wherea show full resist nalidix acid full resist test aminoglycosid colistin reveal strain eighteen differ amr profil elucid half isol share amr profil similar suscept profil rhinotracheal isol found differ farm prove stabil year isol classifi multidrug resist multipl outbreak within flock success flock within farm compris rhinotracheal isol occasion chang suscept antimicrobi substanc observ general chang occur quinolon follow tetracyclin switch main intermedi resist full resist vice versa present surveil provid actual data effect antibiot treatment case diseas outbreak contribut one health concept acknowledg import link anim human health | D045826;D045246;D011201 | T007;T047 |
36,214,405 | challeng implement integr electron health record system breast endocrin clinic tygerberg hospit cape town south africa editor low middl incom countri major patient breast cancer diagnos local advanc diseas remain problem tygerberg hospit breast clinic cape town south africa patient present stage diseas time diagnosi reason cite multipl includ fear unawar diseas sever concern surround lose breast unreli transport referr difficulti financi constraint | D001943;D057286 | T191;T170;T073 |
36,214,404 | right repli editor articl bhorat et al samj entitl cerebr palsi criteria implic intrapartum hypoxia neonat encephalopathi obstetr perspect south african set start rais concern steep rise insur premium place servic deliveri serious threat acknowledg servic deliveri issu alreadi exist public sector obstetr servic south africa sa accord whittak obstetrician gynaecologist employ sa public sector privat sector employ public sector perform privat sector work larg number children cerebr palsi cp deliv public sector servic note bhorat et al fact overwhelm major court case state individu doctor provinc hospit signific medic staf resourc issu exampl liabil eastern cape provinc period zar v zar western cape provinc period | D002547 | T047;T019 |
36,214,402 | medicin law case involv dr tim de maayer gauteng provinc south africa sa rais question whether legal ethic duti public sector doctor whose complaint hospit administr ignor inform public harm child patient due intent maladministr neglig indiffer local provinci author analysi sa constitut nation health act children act health profess act rule guidelin health profess council south africa hpcsa establish term health profess act indic dr de maayer act legal ethic protect child patient rahima moosa hospit complaint harm caus patient condit hospit rais three time offici functionari concern ignor fulli justifi tri measur protect patient seem hope bring condit hospit attent media public reaction would pressuris administr redress situat ironi offici sought disciplin guilti violat constitut nation health act children act disciplin furthermor regist hpcsa report disciplin violat hpcsa ethic rule conduct ethic guidelin good practic | D008318;D010820 | T097;T080 |
36,214,401 | medicin law case babi swap south africa sa rare first case clinton parker v administr transvaal dawkin v administr transvaal appear court parti instanc decid keep babi erron given plaintiff award compens emot shock injuri endur result defend neglig recent time case child law v nn ns gp parti also decid keep children erron given hospit staff scenario difficult amic conclus parent elect pursu custodi natur children situat would complex either parti decid want natur child back number question pertin guid discuss articl simpl psycholog parent return babi natur parent parent claim hospit staff unfortun wealth legal preced assist sa court regard articl explor jurisprud speak babi swap attempt provid clariti assist resolv difficult case | D008318 | T080 |
36,214,398 | carbapenem resist enterobacteral patient bacteraemia tertiari academ hospit south africa updat emerg carbapenem resist enterobacteral cre becom serious signific public health threat worldwid owe limit antimicrobi therapi option elev mortal rate associ infect | D016470;D015780 | T047;T109;T195 |
36,214,397 | third line antiretrovir therapi regist track patient clinic virolog outcom south africa sa estim million peopl live hiv million receiv antiretrovir therapi art million first line art second line art slart third line art tlart | D019380;D015658 | T121;T047 |
36,214,396 | tragedi smoke alcohol multipl substanc use pregnanc antenat substanc use signific public health concern south africa sa inform smoke drink drug use pregnanc collect prospect safe passag studi pass prenat alcohol sudden infant death syndrom stillbirth network | D050497;D019966 | T048;T033 |
36,214,395 | paediatr pain assess manag survey rahima moosa mother child hospit johannesburg south africa pain experi common paediatr inpati popul immatur cognit impair may preclud clear descript experi request analgesia need method pain assess guidelin treatment paediatr popul well establish wide use limit data suggest situat similar south africa sa | D000082;D009035 | T121;T099;T109;T092 |
36,214,394 | ivermectin exposur report poison inform helplin south africa covid pandem ivermectin antiparasit drug shown vitro activ covid clinic studi support ivermectin covid prevent treatment conflict import limit public support ivermectin signific extens label use despit conflict view efficaci ivermectin tablet inject formul regist south africa human use south african health product regulatori author nation depart health current recommend use ivermectin covid | D000086382;D011042 | T047;T131;T067 |
36,214,393 | first report import case haemorrhag fever renal syndrom south africa haemorrhag fever renal syndrom hfrs caus hantavirus infect hantavirus endem south africa report first detect import case hfrs countri case involv travel croatia present johannesburg hospit acut febril ill renal dysfunct patient report visit rural locat hors stabl croatia fall ill worker stabl similar ill diagnos hfrs given exposur histori clinic find case clinic diagnosi hfrs made confirm laboratori test | D006476;D006480 | T047;T005 |
36,214,392 | south african law handl case involv babi swap case babi swap south africa sa rare first case clinton parker v administr transvaal dawkin v administr transvaal appear court parti instanc decid keep babi erron given plaintiff award compens emot shock injuri endur result defend neglig recent time case child law v nn ns gp parti also decid keep children erron given hospit staff scenario difficult amic conclus parent elect pursu custodi natur children situat would complex either parti decid want natur child back number question pertin guid discuss articl simpl psycholog parent return babi natur parent parent claim hospit staff unfortun wealth legal preced assist sa court regard articl explor jurisprud speak babi swap attempt provid clariti assist resolv difficult case | D008318 | T080 |
36,214,390 | asymmetr synthesi isotop atropisom base ortho ch cd discrimin structur properti n c axial chiral trideuteriomethyl dimethylphenyl ethylquinazolin one trideuteriomethyl dimethylphenyl phenylpropan yl quinazolin one prepar high enantio diastereomer puriti ee quinazolinon deriv isotop atropisom base ortho ch cd discrimin reveal possess slight optic rotat high rotat stabil | D013237 | T082;T104;T070 |
36,214,388 | non invas assess intestin permeabl healthi volunt use transcutan fluoresc spectroscopi permeabl intestin barrier alter multitud gastrointestin condit crohn coeliac diseas howev clinic util gut permeabl current limit due lack reliabl diagnost test address issu report novel techniqu rapid non invas measur gut permeabl base transcutan skin fluoresc spectroscopi approach particip drink oral dose fluoresc dye fluorescein fibr optic fluoresc spectromet attach finger detect permeat dye gut blood stream non invas manner valid techniqu clinic trial measur perform healthi particip first h fast particip ingest mg fluorescein dissolv ml water fluoresc measur record fingertip follow h particip invit back repeat studi time ingest solut g sugar ad known transient increas intestin permeabl result two studi dataset without sugar respect analys compar use number analysi procedur includ manual autom calcul seri paramet design assess gut permeabl calcul valu compar use student test demonstr signific differ two dataset thus transcutan fluoresc spectroscopi show promis non invas discrimin two differ state gut permeabl demonstr potenti futur clinic use | D005456;D014867 | T121;T130;T197 |
36,214,382 | relationship mucosa associ gut microbiota human diseas mucus layer cover gastrointestin gi tract play critic role maintain gut homeostasi colon inner mucus layer ensur commens microb kept safe distanc epithelium mucin glycan outer mucus layer provid microb nutrient bind site microb resid mucus form part call mucosa associ microbiota mam microbi communiti due close proxim epithelium profound impact immun metabol health direct impact gut barrier function immun system alter gi microbi communiti link human diseas although knowledg base analysi faecal microbiota grow number studi show mam signatur differ faecal lumin microbiota potenti use distinguish diseas healthi status well studi condit ibd ib crc howev knowledg spatial microbi alter pathogenesi remain sever hamper issu surround access microbi communiti human gut review provid state art inform access mam human composit mam chang mam relat chang human health diseas better understand interact occur mucos surfac essenti advanc understand diseas affect gi tract beyond | D000069196;D064307 | T007;T001;T032;T028 |
36,214,379 | control period reaction diffus wave artifici cell two way energi supplier reaction diffus rd wave dynam self organ structur generat nanos molecul fundament mechan pattern nano micromateri spatiotempor regul live cell cell divis motil although period rd wave critic element function develop system control period challeng rd wave result nonlinear physic dynam far equilibrium condit develop artifici cell system tunabl period rd driven wave min protein wave determin cell divis site plane live bacteri cell develop system base find min wave generat energi consumpt either atp datp period wave differ two energi supplier show min wave period modul linear mix ratio atp datp also possibl estim mix ratio atp datp period find illumin previous unidentifi principl control dissip dynam biomolecul simultan built import framework construct molecular robot spatiotempor unit | D058045 | T075;T073 |
36,214,375 | ab initio molecular dynam investig co adsorpt iodin speci co h silver exchang chabazit field nuclear energi particular interest trap harm iodin speci ch could releas nuclear accid due danger impact human metabol process environ adsorpt iodin molecul versus sever inhibitori compound co h ch cl cl silver exchang chabazit zeolit studi detail use ab initio molecular dynam simul realist temperatur composit interest found iodin molecul remain attach cation even number water molecul insid structur greater two time number cation per cell k co found ch perturb presenc inhibitor overal result indic silver exchang chabazit zeolit promis candid trap iodin speci case sever nuclear accid | D017641;D007455 | T121;T123;T197;T196 |
36,214,373 | strength number effect protein crowd shape cell membran continu reshap plasma membran pleomorph shape critic plethora cellular function cell carri enigmat control membran remodel remain activ research field decad sever molecular biophys mechan shown involv overcom energi barrier associ membran bend report mechan behind membran bend larg concern structur protein featur howev last decad report abil dens pack protein bend membran protein protein crowd challeng prevail mechanist view crowd shown generat spontan vesicl format tubular morpholog cell model membran demonstr crowd relev player involv bend membran still current research larg base unnatur overexpress protein non nativ domain togeth effort model led question vivo impact crowd review examin previous overlook mechan summar recent advanc understand protein protein crowd preval cellular membran shape process | D008565;D004705 | T043;T123;T116;T192 |
36,214,372 | antibacteri nanopattern coat dental implant dental implant usual made titanium expos hostil oral microflora facilit bacteri infect subsequ inflamm mitig process coat titanium substrat block copolym nanopattern investig bactericid effect coat gram posit gram negat bacteria found bactericid efficaci coat depend morpholog surfac chemistri well bacteri strain optim combin lead signific bacteri death short time ie min human gingiv fibroblast contact nanopattern coat show similar cell attach morpholog bare ti immunostain assay show similar level ccr cd macrophag cultur nanopattern bare ti demonstr adequ properti tissu integr nanopattern induc small increas macrophag aspect ratio might indic earli state polar given absenc cd | D014025;D015921 | T074;T196 |
36,214,371 | genom assembl pendleburi roundleaf bat hipposidero pendleburyi reveal expans tcmarin dna transposon rhinolophoidea bat chiroptera constitut second largest order mammal sever distinct featur true self power flight strong immun pendleburi roundleaf bat hipposidero pendleburyi endem thailand list vulner speci employ genom link read technolog obtain genom assembl h pendleburyi assembl size gb scaffold n length base phylogenet analysi place h pendleburyi within rhinolophoid clade subord yinpterochiroptera synteni analysi show h pendleburyi share conserv chromosom segment mb rhinolophus ferrumequinum phyllostomus discolor albeit differ chromosom number belong differ famili found posit select signal gene involv inflamm spermatogenesi wnt signal analys transpos element suggest contract short interspers nuclear element sine accumul young marin dna transposon analys hipposiderid distinct marin like horizont transfer hipposiderid genom evolut famili lineag specif profil sine marin might involv evolut hipposiderid associ phylogenet separ bat bat famili | D002685;D004251 | T015;T123;T086;T114 |
36,214,369 | import cu ag regium bond supramolecular chemistri biolog combin crystallograph ab initio studi identifi character new bind event electron donor acceptor counterpart repres crucial step complet molecular recognit aggreg pictur key chemistri biolog studi interrog pdb protein data bank csd cambridg structur databas presenc cu ag regium rg bond attract noncoval forc element group system concret found evid plausibl biolog role interact protein dna system bacteri ag extrus process heme group redox function furthermor also highlight implic rg bond crystal pack two host guest system interact key bind recognit small organ molecul well encapsul organometal complex theoret model use analys strength interact ri mpdef tzvp level theori togeth qtaim quantum theori atom molecul nbo natur bond orbit nciplot non coval interact plot analys assist character regium interact describ herein expect result studi use attract attent chemic biologist well expand potenti interact supramolecular chemistri crystal engin communiti | D006418;D001695 | T091;T109;T123 |
36,214,366 | select detect character small cystein contain peptid cluster modifi nanopor sens recent demonstr one monitor ligand induc structur fluctuat individu thiolat cap gold nanoclust use resist puls nanopor sens magnitud fluctuat scale size cap ligand later shown one observ ligand exchang nanopor setup expand result explor differ type current fluctuat associ peptid ligand attach tiopronin cap gold nanoclust show fluctuat use identifi attach peptid either magnitud peptid induc current jump onset high frequenc current fluctuat import peptid attach process requir peptid contain cystein residu suggest nanopor base monitor peptid attach thiolat cap cluster could provid mean select detect cystein contain peptid final demonstr cluster base protocol various peptid mixtur show one identifi one cystein contain peptid mixtur | D058608 | T082 |
36,214,363 | evolut toward cyclic structur aggreg aromat alcohol dimer trimer tetram phenylethanol gas phase spectroscop studi alcohol cluster offer accur inform influenc non coval interact molecular recognit paramount import model supramolecular biolog chemic process examin role aliphat side chain self aggreg aromat alcohol use multi methodolog gas phase approach combin microwav spectroscopi mass resolv electron vibrat laser spectroscopi spectroscop electron structur comput carri dimer trimer tetram phenylethanol extend previous investig smaller aromat alcohol conform flexibl ethyl group anticip varieti torsion isom intra inter molecular interact restrict molecular conform favour particular stabl isom conform landscap cluster shallow multipl compet isom rotate andor vibrate detect includ three dimer speci two trimer two tetram cluster growth associ tendenc form cyclic hydrogen bond structur | D010626 | T121;T109 |
36,214,353 | ray trace analysi accommod pseudoaccommod phakic pseudophak eye compar object measur accommod pseudoaccommod phakic pseudo phakic eye use ray trace aberrometri | D007910;D018918 | T061;T074 |
36,214,352 | experiment laboratori studi use miyak appl posterior view techniqu investig dynam capsular bag differ iol model evalu dynam capsular bag differ intraocular len iol model human cadav eye use miyak appl posterior view techniqu | D007903;D007910;D027845;D018918 | T023;T002;T061;T074;T168 |
36,214,351 | comparison astigmat correct without cross axi align small incis lenticul extract compar clinic outcom astigmat correct via small incis lenticul extract smile without cross axi align | D001251;D048988;D000072836 | T061;T047;T037 |
36,214,350 | effect rotat stabil vertic implant implant collam len treatment myopia explor effect rotat stabil vertic implant implant collam len icl staar surgic treat myopia | D009216;D054120 | T047;T074 |
36,214,349 | accuraci intraocular len calcul formula four flang fixat techniqu eye capsular support assess refract predict error four intraocular len iol calcul formula eye undergon scleral fixat use four flang techniqu | D007910;D009216;D018918;D012030 | T061;T047;T074 |
36,214,348 | short term evalu visual qualiti amplitud accommod stereoacu patient moder high myopia underw iclvc implant smile compar visual qualiti accommod stereoacu patient myopia magnitud diopter underw iclvc staar surgic implant small incis lenticul extract smile | D000065;D009216;D014792 | T047;T042;T201 |
36,214,347 | iontophoresi corneal cross link oxygen supplement ovin eye evalu biomechan chang advanc oxid protein product aopp product differ corneal cross link cxl protocol without oxygen supplement | D062107;D007478 | T061;T109 |
36,214,346 | effect modifi haptic surgic outcom rotat stabil toric intraocular len implant assess rotat stabil new toric intraocular len iol tecni toric ii toric ii modifi version tecni toric iol toric frost haptic johnson johnson | D001251;D007910;D018918 | T061;T047;T074 |
36,214,344 | deep learn detector high precis monitor cell encapsul statist microfluid droplet encapsul cell insid microfluid droplet central sever applic involv cellular analysi although theoret encapsul statist expect follow poisson distribut experiment may achiev due lack full control experiment variabl condit therefor need automat detect droplet cell count enumer within droplet process control feedback adjust experiment condit implement studi use deep learn object detector call look yolo influenti class object detector sever benefit tradit method paper investig applic yolov yolov object detector develop autom droplet cell detector experiment data obtain microfluid flow focus devic dispers phase cancer cell microfluid devic contain expans chamber downstream droplet generat allow visual record cell encapsul droplet imag procedur droplet bound box predict crop origin imag individu cell detect separ model examin system includ product set addit perform analysi poisson statist provid experiment workflow droplet cell model train set collect preprocess label appli imag augment allow generaliz object detector precis recal util valid test set metric result high mean averag precis map metric accur droplet detector examin model limit predict compar ground truth label illustr yolo predict close match droplet cell label furthermor demonstr droplet enumer yolov model consist hand count ratio poisson distribut confirm platform use real time experi cell encapsul optim | D046210;D000077321 | T059;T066 |
36,214,343 | identif iron respons gene proteus vulgari iron essenti almost bacteria iron homeostasi precis control ferric uptak regul fur fur regulon well character model bacteria yet littl known common opportunist pathogen proteus vulgari studi fur regulon iron respons gene p vulgari main defin silico proteom analys result show potenti fur regul operon includ transcript factor predict protein exhibit differenti express respons iron defici direct regul fur transcript factor lexa reca narl arca collect result demonstr fur function global regulatori protein repress activ express larg repertoir gene p vulgari besid iron respons gene direct regul fur wherea indirect regul mechan addit transcript regulatori protein | D015964;D007501 | T121;T045;T123;T196 |
36,214,342 | mechan dichlorophenoxyacet acid induc damag rat testi via fasfasl pathway protect effect lycium barbarum polysaccharid herbicid dichlorophenoxyacet acid wide use control broadleav weed associ male infertil studi molecular mechan induc male reproduct system damag protect effect lycium barbarum polysaccharid lbp use spragu dawley rat tm cell treatment caus architectur function chang testi includ collaps atrophi seminifer tubul reduc number spermatozoa scarc sperm epididym duct low level serum testosteron decreas superoxid dismutas glutathion peroxidas activ high malondialdehyd content increas apoptosi testi epididymi express fas fasl fadd pro caspas cleav caspas pro caspas cleav caspas signific increas testicular tissu treat rat prolif activ tm cell decreas increas dose time exposur along enhanc fasfa ligand express decreas concentr inhibin b tm cell cultur medium deplet fas specif shrna transfect revers effect tm cell confirm involv death receptor pathway mediat apoptosi sertoli cell treatment lbp also revers effect testicular cell result improv cell architectur along enhanc prolif capac moreov respons lbp treatment sertoli cell content inhibin b increas level reactiv oxygen speci malondialdehyd decreas activ superoxid dismutas glutathion peroxidas increas rate apoptosi well express fasfa ligand signal pathway protein decreas | D006540;D032305 | T131;T002 |
36,214,341 | role autophagi lysophosphatidylcholin induc apoptosi mous leydig cell lysophosphatidylcholin lpc major class glycerophospholipid ubiquit present tissu play domin role mani diseas still unknown potenti mechan lpc affect testicular leydig cell present studi mous tm leydig cell vitro treat lpc h lpc found signific induc apoptosi oxid stress mous tm leydig cell inhibit oxid stress n acetyl l cystein inhibitor oxid stress could rescu induct apoptosi indic lpc induc apoptosi mous tm leydig cell via oxid stress interest lpc show inhibit autophagi howev induct autophagi rapamycin signific allevi induct apoptosi lpc taken togeth oxid stress involv lpc induc apoptosi mous tm leydig cell autophagi might play protect role lpc induc apoptosi | D007985;D008244 | T025;T109 |
36,214,340 | tetramethyl bisphenol stimul prolifer inhibit fetal leydig cell function male rat target estrogen receptor utero exposur tetramethyl bisphenol tmbpa wide use flame retard tmbpa toxic leydig cell puberti remain unclear whether tmbpa similar inhibitor effect fetal leydig cell flcs studi report morpholog function alter flcs test male offspr birth utero exposur tmbpa pregnant spragu dawley rat dose via continu gavag tmbpa mgkgday gestat day tmbpa mark rais serum total testosteron level testicular volum flc number male offspr mgkg dose regul insl star cypa mrnas observ mgkg tmbpa exposur normal number flcs tmbpa signific reduc lhcgr hsdb express mgkg cypa mgkg parallel protein level tmbpa compromis express esr increas express cdk cdk well protein level tmbpa particular increas phosphoryl akt akt mgkg conclus present studi suggest tmbpa may promot flc prolifer via esr cdk akt pathway inhibit function flcs reduc steroidogen enzym activ | D005411;D007985 | T025;T120 |
36,214,339 | fructos milieu undermin therapeut effect tribulus terrestri extract neuroblastoma cell line via maintain mitochondri function fructos overconsumpt promot tumor progress neuroblastoma common extracrani tumor year surviv rate high risk children anti tumor effect tribulus terrestri might bring new hope neuroblastoma therapi howev whether fructos disturb therapeut effect terrestri current unknown studi mous neuroblastoma cell line neuro na cell use investig therapeut effect terrestri extract various dosag ngml regular emem medium extra ad fructos mm h ngml terrestri treatment signific reduc cell viabil wherea cell viabil enhanc dosag ngml terrestri fructos milieu instead inhibit effect terrestri na migrat blunt fructos milieu moreov terrestri effect suppress mitochondri function includ oxygen consumpt rate activ electron transport enzym express mitochondri respiratori enzym mitochondri membran potenti suppress revers fructos group addit terrestri suppress mitofusin terrestri enhanc mitochondri fission protein maintain basal level fructos milieu togeth result demonstr terrestri extract effect suppress surviv migrat neuroblastoma via inhibit mitochondri oxid phosphoryl disturb mitochondri dynam wherea fructos milieu blunt therapeut effect terrestri particular dosag reduc | D005632;D009447 | T121;T109;T191 |
36,214,338 | swietenin swietenolid swietenia macrophylla king improv insulin secret attenu apoptosi h induc in cell oxid stress import factor caus pancreat cell dysfunct lead develop aggrav diabet swietenin stn swietenolid std isol fruit swietenia macrophylla king potenti effect treatment prevent diabet aim studi investig effect stn std insulin secret apoptosi h induc insulinoma cell line in cell present studi in cell treat h h establish oxid damag model cell apoptosi insulin secret reactiv oxygen speci ros superoxid dismutas sod malondialdehyd mda glutathion gsh level caspas enzym activ measur via correspond method final pancreat duoden home box factor pdx b cell lymphoma bcl bax protein express detect western blot experiment result show stn std could signific improv in cell viabil increas secret insulin reduc ros level h induc in cell furthermor sod gsh level increas mda level decreas compar model group stn std treatment addit treat stn std cell apoptosi improv activ caspas also signific inhibit meanwhil western blot result show stn std could regul express pdx protein affect cell apoptosi pathway regul express bcl protein regul express bax protein conclus stn std signifc improv insulin secret function protect oxid stress injuri reduc apoptosi h induc in cell provid research basi stn std new drug candid treatment prevent diabet | D003920;D029582;D012749 | T047;T002 |
36,214,331 | immunotherapi liposarcoma emerg opportun challeng liposarcoma lps rare adipocyt deriv malign account soft tissu sarcoma although surgeri chemotherapi standard treatment lps larg tumor burden high recurr rate make difficult treat especi diseas progress progress immunotherapi tumor melanoma lung cancer interest risen explor immunotherapi lps review discuss understand tumor microenviron lps current status immunotherapi lps includ immun checkpoint inhibitor adopt cell therapi cancer vaccin oncolyt virus combin therapi futur direct exploit strategi make effect immunotherapi stronger durabl | D008080;D019496;D050504 | T116;T191;T121;T129;T005 |
36,214,325 | biodegrad bioelectron biomed applic biodegrad polym wide use tissu engin potenti replac regen tissu convent bionic interfac design implant live tissu organ perman biocompat biodegrad electron materi progress paradigm shift toward transient regen bionic engin exampl biodegrad bioelectron monitor physiolog bodi transient rehabilit diseas symptom seamless form regen interfac synthet electron devic tissu reduc inflammatori foreign bodi respons convent electron materi readili consid biodegrad howev sever strategi adopt design electroact biodegrad materi system conduct materi blend biodegrad compon molecular engin conjug polym biodegrad moieti natur deriv conjug biopolym aqueous dissolv metal encapsul layer review endeavor present technic bridg electr activ biodegrad materi system edibl biodegrad electron well transient bioelectron pre clinic bio instrument applic includ biodegrad sensor neural tissu engin intellig drug deliveri system | D001672;D023822 | T061;T122 |
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