PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,215,085 | pediatr sepsi import understand criteria diagnosi pediatr sepsi signific issu pediatr popul sepsi defin relat system inflammatori respons syndrom character base sever includ sever sepsi septic shock multiorgan failur refractori septic shock set proven infect suspect infect pediatr popul sepsi complic danger event one specif criteria definit system inflammatori respons syndrom criteria applic everi child suffer condit goal paper enhanc awar various form sever sepsi pediatr popul swift diagnosi made treatment initi electron literatur review search perform relev data collect peer review articl januari may nonspecif natur condit manifest cardiovascular dysfunct hematolog abnorm neurolog symptom result late diagnosi ultim lead increas mortal morbid implic sepsi pediatr popul need address imper medic profession includ medic student understand criteria rais high level suspicion present child exhibit symptom may indic sepsi increas awar pediatr sepsi complic includ death aris result late diagnosi treatment would substanti decreas pediatr ann e e | D018805;D012772 | T047;T046 |
36,215,084 | respiratori syncyti virus respiratori syncyti virus rsv ubiquit virus infect near everi child second birthday caus wide array symptom rang mild cold respiratori failur even death ill everi general pediatrician encount year basi import know popul risk sever diseas protect rsv treat contract mani prevent measur studi far rsv prove challeng virus captur control technolog knowledg grow hope vaccin attain longer last immunoprophylaxi better treatment option contract diseas pediatr ann e e | D018357;D018113 | T047;T005 |
36,215,077 | multi institut valid improv vesicoureter reflux assess simpl machin learn approach vesicoureter reflux grade void cystourethrogram high subject low reliabl aim demonstr improv reliabl vesicoureter reflux grade simpl machin learn approach use ureter tortuos dilat void cystourethrogram | D014718;D014513 | T047;T023 |
36,215,074 | clinic trial enrol inelig reason declin older vs younger patient cancer nation cancer institut communiti oncolog research program cross section studi assess differ clinic trial particip among older vs younger adult cancer | D002986;D009369;D018579 | T191;T058;T062;T080 |
36,215,073 | trend obes preval among patient enrol clinic trial obes relat cancer obes rate risen unit state sinc sever studi shown link obes incid specif cancer type none systemat examin obes preval time cancer diagnosi among clinic trial particip may affect clinic outcom | D009369;D050177 | T191;T033 |
36,215,072 | placebo respons oral administr osteoarthr clinic trial associ factor model base meta analysi osteoarthr oa clinic trial placebo often use control therefor thorough understand placebo respons import guid drug develop oa | D020370 | T047 |
36,215,071 | blood leukocyt count alzheim diseas emerg evid implic role neuroinflamm alzheim diseas ad pathogenesi predomin involv innat immun system blood leukocyt count easili access marker immun function howev associ risk ad unknown | D000544 | T047;T048 |
36,215,070 | misrepresent nonadher regard covid public health measur effect public health measur implement mitig spread impact sar cov reli heavili honesti adher general public | D000086382 | T047;T067 |
36,215,069 | covid symptom durat rapid antigen test posit communiti test surveil site pre delta delta omicron ba period character clinic symptom evolut communiti base sar cov infect may inform health practition public health offici rapid chang landscap popul immun viral variant | D000086382;D010612 | T047;T184;T067 |
36,215,068 | associ multimorbid excess mortal fractur among danish adult limit knowledg interact among health disord imped optim patient care comorbid common among patient year older fractur fractur provid use set studi interact among disord | D006620;D058866 | T047;T037 |
36,215,063 | estim global proport individu persist fatigu cognit respiratori symptom cluster follow symptomat covid individu experi persist symptom initi symptomat sar cov infect often refer long covid | D000086382;D005221;D003072;D012131 | T047;T046;T048;T184;T067 |
36,215,060 | thorac spine deform may predict prosthet rehabilit outcom consider number patient requir prosthet ambul necessit improv success rate prosthet | D001186 | T074 |
36,215,059 | preliminari result physiotherapi scoliosi specif exercis spine joint posit sens adolesc idiopath scoliosi random control trial observ difficulti maintain spinal harmoni absenc propriocept inform import role achiev postur control scoliosi one test use evalu propriocept mechan joint posit reproduct | D007738;D012600 | T047;T190 |
36,215,058 | preliminari analysi reliabl valid life space questionnair real world mobil measur peopl lower limb loss technic note peopl lower limb loss pll often reduc mobil translat limit communiti access life space questionnair lsq measur person real world mobil within home environ communiti use among pll studi assess preliminari lsq test retest reliabl discrimin valid subject object balanc walk measur pll addit lsq hypothes invers associ overal health status nine subject analyz mean age year year time sinc amput six transtibi three transfemor amput due diabet vascular diseas trauma primari outcom lsq level scale quantifi extent peopl access life space includ home yard communiti test retest reliabl lsq moder intraclass coeffici confid interv discrimin valid balanc walk function demonstr lack correl lsq score activ specif balanc confid berg balanc scale prosthet evalu questionnair mobil subscal walk speed r lsq correl health status assess charlson comorbid index r p sampl pll lsq demonstr moder test retest reliabl measur real world mobil distinct construct subject object balanc walk measur peopl may access communiti use various level assist method transport sampl pll health status strong associ lsq score | D001186 | T074 |
36,215,057 | attitud behavior toward use outcom measur clinic practic find blend educ program outcom measur om import healthcar barrier use blend educ program design teach orthot prosthet profession standard practic collect use om facil studi use singl group pretest post test mix method survey evalu effect blend educ program orthot prosthet profession incorpor om routin clinic practic | D001290;D017063 | T081;T055;T078;T041;T057;T062 |
36,215,056 | comparison thick talar cartilag tibiali anterior gastrocnemius muscl high activ patient unilater traumat transtibi amput nonamput individu clinic sonograph studi aim studi compar thick intact talar cartilag tibiali anterior ta gastrocnemius mediali gcm gastrocnemius laterali gcl muscl traumat unilater transtibi ampute nonamput individu ultrasound investig relationship cartilag muscl thick measur clinic paramet | D000674;D001186 | T101;T074 |
36,215,048 | continu rise unintent ingest edibl cannabi toddler grow public health concern viewpoint discuss critic need research regard percept edibl cannabi effect method educ screen caregiv innov approach safe storag consid increas unintent ingest cannabi edibl among children | D002188;D000074609 | T002;T167;T121;T055;T109;T048 |
36,215,046 | physician attitud use life expect inform cancer screen cessat older adult result nation survey survey studi assess physician attitud use life expect guid decis stop cancer screen older adult | D010820;D009369 | T191;T097 |
36,215,045 | new progress medic condit pediatr sepsi hospit requir critic care children common experi physic cognit emot sequela sepsi howev littl known develop progress medic condit pediatr sepsi | D018805;D051436;D004827;D012131 | T047;T046;T033 |
36,215,043 | effect increas interprofession familiar team perform communic psycholog safeti inpati medic team random clinic trial larg academ center medic resid work multipl clinic floor transient interact nurs colleagu although teamwork critic deliv high qualiti medic care littl research evalu effect interprofession familiar inpati team perform | D007297;D010820 | T101;T097 |
36,215,040 | thyclotid tetrahydrofuran modifi peptid nucleic acid effici penetr cell inhibit microrna peptid nucleic acid pnas promis therapeut molecul gene modul howev suffer poor cell uptak deliveri pnas cell requir conjug pna anoth larg molecul typic cell penetr peptid nanoparticl studi describ new pna base molecul cyclic tetrahydrofuran thf backbon modif case consider improv cell uptak refer thf pna oligom thyclotid thf group everi posit oligom cell uptak thyclotid target mir enhanc compar correspond unmodifi pna base aminoethylglycin backbon optim thyclotid effici enter cell without use cell penetr peptid bind mir design microrna target decreas express mir increas express three downstream target pten cdca krit use plasmid pten utr coupl luciferas confirm mir target thyclotid prevent mir bind target rna addit thyclotid show cytotox administ time activ concentr propos thyclotid explor therapeut candid modul mirna level | D020135;D035683;D057846 | T123;T116;T114 |
36,215,039 | two type topoisomeras maintain dna topolog human mitochondria genet process requir activ multipl topoisomeras essenti enzym remov topolog tension intermolecular linkag dna investig subcellular localis activ six human topoisomeras view understand topolog mainten human mitochondri dna result indic mitochondria contain two topoisomeras topmt topa use molecular genom biochem method find protein contribut mtdna replic addit decaten role topa topmt stimul mtssb loss topa topmt also dysregul mitochondri gene express protein promot transcript elong vitro find evid top localis mitochondria topb knockout affect mtdna mainten express result suggest divis labour topa topmt mtdna topolog control requir proper mainten express human mtdna | D008928;D004272 | T043;T026;T123;T114 |
36,215,038 | photoactivat immunostimulatori nanomedicin immunometabol cancer therapi ration design immunostimul cc sio plg photoactivat immunotherapeut function synerget tumor therapi report cc sio plg nanoplatform compris catalas photosensit ce co encapsul silica capsul immunostimul conjug reactiv oxygen speci cleavabl linker accumul tumor tissu cc sio plg generat reliev tumor hypoxia promot product singlet oxygen upon laser irradi result tumor destruct also releas tumor associ antigen taa simultan linker breakag photoproduc lead remot control releas conjug indoleamin dioxygenas ido inhibitor cc sio plg consequ immunosuppress tumor microenviron revers releas taa conjunct inhibit ido mediat tryptophankynurenin metabol pathway induc boost antitumor immun respons cc sio plg mediat phototherapi therefor growth primarydist tumor lung metastas mous xenograft model great inhibit achiev phototherapi alon | D017319;D009369 | T121;T039;T191 |
36,215,034 | anti crispr protein function thermodynam tune alloster regul crispr rna guid surveil complex crispr rna guid detect degrad foreign dna dynam process virus interfer cellular defens express small protein call anti crispr structur model anti crispr bound target complex provid static snapshot inform mechan dynam thermodynam interact often overlook use hydrogen deuterium exchang mass spectrometri hdx ms differenti scan fluorimetri dsf experi determin anti crispr bind impact conform landscap type crispr rna guid surveil complex csi upon bind two differ anti crispr protein acrif acrif result demonstr acrif bind reli enthalp stabil wherea acrif use entropi driven reaction bind crispr rna guid surveil complex collect work reveal thermodynam basi mechanist versatil anti crispr mediat immun suppress broad work present strike exampl alloster effector employ regul nucleoprotein complex | D064130 | T123;T116 |
36,215,031 | picker emuls stabil ligninchitosan nanoparticl biphas enzym catalysi studi construct green high perform platform use picker emuls biphas catalysi oil water picker emuls stabil ligninchitosan nanoparticl ligchi nps great stabil alkali resist show ph respons revers emulsif demulsif recycl least three time picker emuls also fluoresc wide avail differ oil water volum ratio type oil storag time temperatur ion concentr system appli lipas catalyz reaction hydrolysi p nitrophenol palmit provid stabl larg oil water reaction interfac area negat charg lipas enrich emuls interfac electrostat adsorpt posit charg ligchi nps achiev immobil lipas ligchi nps reaction convers rate reach near min near three time higher convent two phase system moreov lipas picker emuls stabil ligchi nps exhibit great recycl protect ligchi nps | D048271;D053758 | T121;T109;T073 |
36,215,023 | plant trait help design green wall urban air pollut control short review scientif evid knowledg gap often claim green wall gw live wall system lws posit effect urban air pollut problem plant composit optim design lws depth review knowledg plant trait maxim gw effect air pollut show might hasti conclus still import knowledg gap robust conclus drawn particul matter pm pollut analyz suffici number studi conclud leav hairstrichom effect captur pm rougher smaller leaf pm catch analysi plant composit six lws belgium indic lws support plant communiti domin speci exhibit major effect trait maxim pm captur regard climb plant three seven common use creeper belgium present hairstrichom leav studi conduct pollut trait requir optim gw plant composit maxim effect air qualiti | D000393;D000397 | T069;T131;T080 |
36,215,009 | environment friend energi consumpt spur econom progress empir evid nordic countri explor energi use growth nexus proffer valuabl clue policymak stakehold econom environment sustain target unlik extant studi studi focus effect renew energi consumpt econom progress nordic countri includ denmark sweden norway finland iceland empir analysi encompass two distinct renew energi consumpt indic account influenti factor like research develop r expenditur human physic capit compon within tradit growth model framework dcce estim deploy empir analysi cover avail sampl data result estim impact renew energi consumpt econom progress vari accord measur vis vis util indic renew total energi use indic distinct renew power sourc biofuel case former indic impact insignific posit signific impact growth seen across model evalu use gdp per capita incom level nordic countri latter indic furthermor r expenditur human capit compon essenti signific long run driver econom growth incom level bloc physic capit format produc contrari evid econom progress bloc polici implic recommend enhanc econom progress suggest main text nordic countri view renew energi develop bloc environment sustain drive notabl strateg polici implement gear toward encourag r expenditur especi renew energi develop facilit econom growth incom level posit nordic bloc environment sustain path | D056804;D002245 | T109;T123;T197 |
36,214,987 | autophagi neuron prefront cortex hippocampus rat trimethyltin chlorid intox ultrastructur studi hippocampus prefront cortex rat perform day damag neurotoxic trimethyltin chlorid tmt signific damag neuron observ brain structur hippocampus larg number autophagosom per appear soma neuron dendrit axon day intox addit observ appear hyperchrom neuron abnorm structur mitochondria prefront cortex damag neuron also contain autophagosom number signific lower per number autophagosom decreas increas time tmt administr day inject content autophagosom hippocampus per prefront cortex autophagosom longer found hypothes autophagi hippocampus effect enough prevent neuron death caus neurotoxic | D014298 | T121;T109 |
36,214,986 | method assess stabil region blood circul human new non invas method assess stabil function human region circulatori system develop method includ synchron measur level cutan blood microcircul symmetr area pair human organ laser doppler flowmetri subsequ mathemat analysi dopplerogram use origin comput experiment techniqu base mathemat model develop us form system differenti equat describ experiment pattern left right asymmetri oscillatori process human region circulatori system propos method allow evalu reserv capabl region circulatori system patient increas inform valu studi non invas method use clinic practic perform person assess stabil region blood circul predict risk vascular patholog | D017078 | T060 |
36,214,985 | effect combin treatment compound affect mitochondria physiolog paramet old monkey correct mitochondri function promis direct modul age process effect nad form precursor nicotinamid mononucleotid nmn antioxid mitoq specif affect mitochondria studi male rhesus monkey macaca mulatta first group anim initi receiv nmn second group receiv mitoq group receiv drug simultan treatment lead chang bodi weight bodi temperatur hemostasi ecg use mitoq nmn improv hematolog biochem paramet shift valu young anim chang paramet depend anim age use mitoq effect certain age combin use two drug clear advantag mitoq alon | D009243;D009537 | T121;T123;T114 |
36,214,984 | glucocorticoid receptorhcn channel interact spinal dorsal horn particip regul neuropath pain peripher nerv injuri rat studi interact glucocorticoid receptor gr hcn channel rat model spare nerv injuri sni spragu dawley rat n anim random divid group sham oper n sni refer group n experiment sni group intrathec treat dexamethason dex gr agonist n ru gr antagonist n zd hcn channel blocker n zddex n paw mechan withdraw threshold pwt measur one day surgeri group day surgeri behavior result show mechan hyperalgesia appear day sni pwt decreas gradual time express gr hcn channel l l dorsal horn spinal cord detect western blot immunohistochemistri refer group sni signific increas gr express day surgeri comparison group express gr show tendenc increas dex group maximum express day signific increas ru group maximum day zd group gr express lower sni group chang throughout experi suggest zd could block express gr dex group express hcn channel signific higher day sni differ paramet ru zd group zddex group express hcn channel signific increas day sni thus gr hcn linkag format central sensit sni antagonist signific effect improv pain behavior | D009437;D059348 | T047;T184;T037 |
36,214,970 | valoctocogen roxaparvovec first approv valoctocogen roxaparvovec roctavian gene therapi develop biomarin pharmaceut inc treatment haemophilia august valoctocogen roxaparvovec grant condit market author eu treatment sever haemophilia congenit factor viii fviii defici adult without histori fviii inhibitor without detect antibodi adeno associ virus serotyp aav articl summar mileston develop valoctocogen roxaparvovec lead first approv sever haemophilia | D006467 | T047 |
36,214,941 | pre diabet diabet hyperglycemia stroke bittersweet therapeut opportun diabet mellitus dm caus system vascular complic chronic hyperglycemia hallmark dm appear least partial respons vascular complic addit hyperglycemia acut tissu injuri postul augment injuri review address potenti therapeut benefit relat ischem stroke lower hyperglycemia two set chronic hyperglycemia acut ischem stroke | D011236;D000083242;D006943;D020521;D003920;D002545 | T047;T046;T033 |
36,214,931 | expect artifici intellig ai psychiatri artifici intellig ai often present transform technolog clinic medicin even though current technolog matur ai low purpos narrat review describ complex reason low technolog matur set realist expect safe routin use ai clinic medicin | D001185;D011570 | T073;T066;T090;T091;T097 |
36,214,930 | climat chang impact mental health lead increas digit mental health care evid impact climat chang mental health individu communiti review literatur import digit system reduc carbon emiss address | D011570;D000086382;D017216 | T047;T058;T091;T097;T067 |
36,214,929 | ag ag decor multi wall carbon nanotubesnico hydrotalcit sensor trace nitrit quantif ag ag decor multiwal carbon nanotubenico hydrotalcit cntldh ag composit design synthes nitrit quantif materi character various techniqu electrochem detect perform investig use amperometr differenti puls voltammetri dpv techniqu ag ag nanoparticl nps anchor surfac cntldh ag composit suitabl amount ag ag load ag ag nps small particl size distribut even cntldh surfac increas surfac area composit optim cntldh ag composit exhibit high electrochem activ oxid ph furthermor optim cntldh ag composit fabric trace quantif propos sensor display high sensit cm fast respons toward wide linear rang moll mmoll low detect limit moll sn sensor provid outstand analyt perform desir recoveri rsd real sampl result propos sensor use real time quantif trace biolog food environment field | D037742 | T104;T073 |
36,214,928 | effect feed chickpea grain lactat perform blood metabolit ewe experi conduct see replac soybean meal chickpea grain chpe affect perform milk product digest nitrogen n balanc blood metabolit awassi ewe thirti awassi ewe initi bodi weight kg age year select random assign differ feed treatment ewe per diet dietari dri matter dm gkg chpe con gkg chpe chpe gkg chpe chpe cost diet determin use current ingredi price experi last week trial ewe lamb kept individu pen daili nutrient intak monitor everi week bodi weight bw milk output composit ewe measur comparison con diet ad chpe experiment diet lower feed cost us per ton chpe chpe chpe group lower p consumpt neutral deterg fiber ndf chpe group con group highest p intak ndf intak ether extract ee gd higher p ewe fed chpe compar ewe fed chpe lowest ewe fed con diet ewe fed chpe chpe diet total solid gkg kg milk produc per day higher p fed con diet cost per kg milk produc ewe lower p chpe ad diet ewe chpe chpe diet compar ewe con diet crude protein cp digest higher p ee digest higher p chpe group chpe group intermedi outcom chpe group lower amount n fece urin p group retent n g g ewe fed chpe chpe diet higher p ewe fed con diet result current research demonstr part soybean meal barley grain could replac chickpea diet lactat awassi ewe | D029863;D007774 | T042;T168;T002 |
36,214,927 | assess ismailia canal irrig purpos water qualiti indic ismailia canal one signific stream nile river egypt studi aim determin water qualiti ismailia canal base region season variabl physicochem paramet irrig criteria irrig water qualiti index iwqi observ physicochem paramet within accept fao irrig limit cation anion valu within accept fao limit irrig except potassium k concentr permiss irrig limit one way analysi varianc anova suggest signific season variat canal water qualiti concern paramet p valu howev region variat among various site statist insignific p valu statist analysi use calcul correl coeffici differ paramet studi show high signific correl coeffici differ pair water qualiti paramet correl matrix show ph signific affect iwqi r irrig criterion valu ismailia canal good wqi level irrig util studi site satisfactori deterior water qualiti may occur due industri municip agricultur activ drainag water treat mix irrig water improv suitabl irrig | D060587;D014874 | T082;T131;T081;T070 |
36,214,920 | comput investig acceptor substitu influenc metal free effici chromophor optoelectron properti studi comput studi po h conhoh h molecul investig optoelectron applic basi tetrahydroquinolin c dye besid detail calcul molecular structur energi level drive forc inject regener non linear optic nlo properti chemic hard excit bind energi light harvest effici lhe absorpt spectra photovolta pv paramet discuss detail use densiti function theori dft time depend dft td dft method optoelectron properti c base molecul origin tune chang posit acceptor get maximum absorpt spectrum c beck three paramet lee yang parr blyp coulomb attenu method blyp cam blyp head gordon model bxd use td dft method result reveal td bxd g combin function provid reliabl effect c therefor absorpt spectra dye follow td bxd g techniqu design po h dye display smaller energi gap red shift broaden spectra dye c util get better pv properti addit nlo properti chromophor calcul polariz first order hyperpolariz consequ dye superior valu nlo activ studi deliv valuabl refer upcom molecular propos tetrahydroquinolin dye optoelectron applic | D004396 | T109;T130;T197 |
36,214,918 | treatment heavi metal pollut sewag sludg use biochar amend vermistabil heavi metal contamin sewag sludg hamper recycl contamin sewag sludg amend differ proport biochar vermistabil biochar produc wheat straw ad four proport ten earthworm eisenia fetida ad sludg vermistabil day heavi metal nutrient concentr accumul metal e fetida measur treatment biochar effici reduc concentr heavi metal concentr cd decreas cr cu pb concentr plant nutrient increas total n total p total k e fetida accumul heavi metal intern tissu surviv reproduct rate e fetida improv vermistabil process interpret biochar alon improv decomposit process main actor earthworm e fetida effici proport biochar highest test recommend biochar use vermistabil heavi metal contamin municip sewag sludg studi benefit manag heavi metal contamin sewag sludg agricultur final vermistabil product use improv crop product | D019216;D009835;D012989 | T131;T196;T204 |
36,214,917 | microorgan biolog control strategi manag microbi plant pathogen review chemic fertil pesticid integr part modern agricultur often associ numer environment problem biolog agent microorgan larg replac chemic fertil pesticid proper use select microorgan bacteria fungi virus sever benefit agricultur includ healthi soil microbiota biolog product import compound promot plant health use biocontrol agent bcas provid protect plant pathogen microorgan scientist found sever bacteri genera includ bacillus pseudomona antimicrobi activ numer pathogen bacteri fungal plant pathogen trichoderma aspergillus penicillium among common fungal genera use bcas bacteri fungal plant pathogen sever bacteriophag mycovirus also found effect bcas select plant pathogen fusarium oxysporum common found microbi plant pathogen caus wilt rot plant overal conclud use microbi bcas effect practic microbi plant pathogen | D000890;D010575 | T121;T131 |
36,214,905 | enhanc biodegrad oil contamin soil oil shale gas exploit biochar immobil enhanc biodegrad oil contamin soil fix microorgan corn cob biochar investig found compon oil test soil main straight chain alkan branch alkan use corn cob biochar carrier immobil microorgan best particl size corn cob biochar immobil carrier mm best immobil time h sem analysi confirm microorgan immobil corn cob biochar immobil microorgan exhibit high biodegrad stress high concentr petroleum pollut heavi metal organ pollut infrar spectroscopi analysi show oxygen contain group hydroxyl carboxyl methoxi surfac biochar involv complex heavi metal mechan immobil promot microbi degrad oil contamin explain gas chromatographi mass first alkan aromat adsorb corn cob biochar pass immobil microorgan promot degrad bioavail increas especi aromat second biochar provid suitabl environ microorgan degrad third convers keton acid acceler biodegrad alkan biodegrad alkan acceler immobil biodegrad effici oil immobil microorgan soil within day higher free microorgan degrad immobil microorgan high correl activ catalas ureas polyphenol oxidas | D012989;D010578;D019216 | T109;T131;T196 |
36,214,898 | ventriculosubgal shunt propos techniqu post infecti hydrocephalus manag post infecti hydrocephalus pih remain challeng neurosurgeon requir temporari divers procedur till normal csf paramet prior perman one ventriculosubgal shunt vsgs wide use pediatr case post hemorrhag hydrocephalus phh howev role pih still lack studi done elucid safeti efficaci vsgs temporari csf divers procedur perman one patient pih | D058565;D006849;D008581 | T047;T019;T033 |
36,214,882 | predict valu sofa score procalcitonin septic shock percutan nephrolithotomi investig valu combin sequenti organ failur assess sofa score procalcitonin pct predict septic shock percutan nephrolithotomi pcnl total patient receiv pcnl renal calculi alloc control group without septic shock septic shock group relat data retrospect collect univari analysi first perform variabl two side p includ logist regress analysi determin independ risk factor receiv oper characterist roc curv util evalu predict valu area curv auc compar use z test postop septic shock develop patient develop patient multivari analysi demonstr sofa score ci pct ci oper time ci independ risk factor septic shock adjust sex histori urolithiasi surgeri posit histori urin cultur histori pcnl roc curv demonstr auc sofa score pct predict septic shock pcnl ci ci respect auc combin ci higher individu predict vs z p vs z p sofa score pct could appli predict septic shock pcnl combin could elev diagnost abil | D012772;D000074642;D018805;D007669 | T061;T047;T046 |
36,214,881 | surgic posit affect infect complic percutan nephrolithotomi downward orient access sheath supin percutan nephrolithotomi pcnl allow faster evacu fluid stone fragment theoret contribut reduct high intraren pressur associ complic aim investig whether differ prone supin pcnl term infect complic retrospect studi includ patient underw supin prone pcnl due kidney stone clinic april may demograph age sex bodi mass index comorbid radiolog cumul stone burden stone densiti number stone stone local stone later presenc hydronephrosi clinic previous stone surgeri previous urinari tract periop prone supin posit surgeri durat hospit success non infect infect complic data patient evalu patient divid two group prone posit group supin posit group two group compar term pre postop data infect complic observ patient prone posit group patient supin posit group differ statist signific p surgeri durat ci p number stone ci p previous urinari tract infect ci p prone posit ci p found independ risk factor infect complic prone posit prove independ predictor postop infecti event supin pcnl adopt standard pcnl approach continu grow proport endourologist | D000074642;D009403;D007669 | T061;T047 |
36,214,872 | function character colchicum autumnal l doubl bond reductas cadbr colchicin biosynthesi alken doubl bond reductas enzym cadbr clone colchicum autumnal l encod enzym catalys coumaraldehyd hydroxydihydrocinnamaldehyd hdca function character increas understand colchicin biosynthesi tradit medic plant colchicum autumnal l famous produc colchicin wide use drug allevi gout attack biosynthet pathway colchicin reveal recent hydroxydihydrocinnamaldehyd hdca verifi crucial intermedi deriv l phenylalanin howev function gene catalys format hdca remain controversi studi alken doubl bond reductas dbr gene member cadbr clone character c autumnal bioinformat analysi predict character basic physicochem properti cadbr recombin cadbr protein heterolog express escherichia coli purifi ni nta column vitro enzym assay indic cadbr could catalys coumaraldehyd form hdca could generat hdca take cinnamaldehyd substrat stabl transform tobacco cell reveal cadbr local cytoplasm tissu specif express result show cadbr highest express bulb result verifi confirm particip contribut cadbr biosynthesi pathway hdca colchicin alkaloid c autumnal | D000470;D003079 | T002;T131;T121;T109;T123 |
36,214,853 | efficaci safeti selinexor base regimen relapsedrefractori multipl myeloma systemat review literatur incorpor novel agent earlier line therapi increas number multipl myeloma patient refractori tradit class drug selinexor combin dexamethason emerg viabl option heavili pretreat tripl class relaps refractori multipl myeloma rrmm systemat review analyz avail literatur role selinexor rrmm boston trial demonstr selinexor combin dexamethason bortezomib associ better depth durat respons without excess toxic compar bortezomib dexamethason alon similar selinexor combin carfilzomib dexamethason found durabl respons toler safeti profil carfilzomib naiv carfilzomib refractori rrmm patient selinexor combin imid lenalidomid pomalidomid well cd monoclon antibodi daratumumab also promis result selinexor combin therapi safe effect patient pretreat rrmm | D009101 | T191 |
36,214,850 | robot hernia surgeri iv german version robot parastom hernia repair video report preliminari result surgic treatment parastom hernia consid complex known prone complic tradit condit treat use reloc techniqu local sutur repair sinc sever mesh base techniqu propos nowaday use minim invas surgeri sinc introduct robot assist surgeri field abdomin wall surgeri sever adapt techniqu made may signific improv patient outcom contribut provid overview avail techniqu robot assist parastom hernia repair technic consider preliminari result robot assist modifi sugarbak repair robot assist pauli techniqu minim invas use funnel shape mesh treatment parastom hernia present furthermor challeng robot assist ileal conduit parastom hernia repair discuss techniqu illustr photograph video materi besid provid comprehens overview robot assist parastom hernia repair articl focus specif advantag robot assist techniqu treatment condit | D065287;D012371;D000069290 | T046;T061;T090 |
36,214,849 | influenc clonal hematopoiesi non hematolog diseas age process occurr clonal hematopoiesi caus acquir somat mutat leukemia associ gene blood stem cell common popul increas age besid increas risk develop myeloid neoplasm unexpect causal relationship clonal hematopoiesi cardiovascular diseas recent discov clonal hematopoiesi present new independ strong risk factor cardiovascular diseas atherosclerosi coronari heart diseas heart failur aortic valv stenosi stroke medic perspect longer ignor worldwid intens research associ clonal hematopoiesi age relat infecti diseas identifi increas ill influenc presenc mutat blood cell current data describ fatal vicious circl initi somat blood cell mutat acceler progress associ diseas proinflammatori way feed back hematopoiesi lead enlarg mutat blood cell clone first experiment treatment approach break vicious circl discuss causal relationship under pathomechan center research interest order rapid establish risk stratif therapeut measur benefit patient near futur | D000082182;D002318 | T047;T033 |
36,214,847 | multipl centrosom enhanc migrat immun cell effector function matur dendrit cell centrosom play crucial role immun cell interact initi immun respons prolifer cell centrosom number tight control general limit one g two prior mitosi defect regul centrosom number associ cell transform tumorigenesi report emerg extra centrosom leukocyt immun activ upon antigen encount dendrit cell pass incomplet mitosi arrest subsequ g phase lead tetraploid cell accumul centrosom addit cell stimul increas express polo like kinas result diploid cell two centrosom g arrest cell cell migrat centrosom tight cluster act function microtubul organ center allow increas persist locomot along gradient chemotact cue moreov dendrit cell extra centrosom display enhanc secret inflammatori cytokin optim cell respons togeth result demonstr previous unappreci role extra centrosom regular cell tissu homeostasi | D018385;D003713 | T026;T025 |
36,214,845 | model effect hydrophob passiv permeat solut across bacteri model membran passiv diffus across biomembran import mechan permeat multipl drug includ antibiot howev process frequent neglect studi drug uptak view warrant investig appli molecular dynam simul investig impact chang molecular hydrophob permeabl seri inhibitor quorum sens pseudomona aeruginosa previous discov us across membran model overal show permeat across membran model correl molecul hydrophob demonstr use simpl model permeat base differ maximum minimum free energi profil outperform inhomogen solubl diffus model yield permeabl rank better agre experiment result especi hydrophob permeant calcul differ permeabl could explain differ bacterio activ nevertheless substanti differ molecular orient along permeat pathway correl bacterio activ emphas import analyz atomist level permeat pathway solut | D056004;D000900 | T121;T044;T066;T195 |
36,214,844 | design xenopus glp base long act dual glp receptor agonist glp receptor glp r neuropeptid receptor r dual agonist shown great potenti treat obes type diabet tdm develop multitarget strategi design monomer agonist base xenopus glp xglp pyy analogu dual activ activ glp r r novel peptid q obtain via stepwis structur optim vitro receptor screen db db diet induc obes dio mice q produc greater effect long term glycem control bodi weight reduct glp r r monoagonist counterpart notabl high fat diet induc nonalcohol steatohepat nash mice q treatment signific reduc hepat triglycerid total cholesterol level revers hepat steatosi compar glp r monoagonist liraglutid treatment collect data support therapeut potenti glp ry r dual agonist q novel antidiabet antiobes antisteatot agent | D003924;D065626 | T047 |
36,214,842 | studi interact four typic carotenoid human gut microflora use vitro ferment model recent studi indic strong relationship carotenoid gut microflora howev structur activ relationship remain unclear studi evalu interact four typic carotenoid caroten lutein lycopen astaxanthin gut microflora use vitro ferment model h ferment retent rate four carotenoid time lower without gut microflora control group respect four carotenoid treat group signific increas total short chain fatti acid scfas product carotenoid supplement signific promot abund roseburia parasutterella inhibit abund collinsella caroten lutein lycopen astaxanthin signific promot abund ruminococcu sutterella subdoligranulum megamona respect furthermor xanthophyl signific impact gut microflora caroten studi provid new way understand carotenoid work human bodi exist gut microflora | D002338;D000069196 | T007;T121;T001;T109;T123 |
36,214,834 | noninvas intra abdomin pressur measur critic ill patient intra abdomin hypertens iah frequent phenomenon iah defin intra abdomin pressur iap persist mm hg abdomin compart syndrom defin iap persist pressur mm hg combin newli occur organ failur bladder pressur serv surrog paramet iap measur noninvas standard manner undetect untreat iah worsen prognosi critic ill patient | D016638;D059325 | T047 |
36,214,815 | endonucleas assist pam free recombinas polymeras amplif coupl crisprcasa e pfrpaca sensit detect dna methyl dna methyl consid potenti cancer biomark evalu dna methyl level contribut prognosi diagnosi cancer herein propos novel assay base endonucleas assist protospac adjac motif pam free recombinas polymeras amplif coupl crisprcasa e pfrpaca sensit detect dna methyl methyl sensit restrict enzym msre first use select digest unmethyl dna methyl target remain structur intact therefor methyl target initi rpa reaction generat larg amount doubl strand dna dsdna avoid depend pam site crisprcasa one rpa primer design phosphat terminus treat lambda sequenc phosphat modif degrad leav singl strand dna ssdna crisprcasa accur locat ssdna without pam initi tran cleavag activ signal amplif meanwhil non specif amplif also avoid lambda effect filter detect background benefit specif msre high amplif effici lambda assist rpa self amplif effect crisprca e pfrpaca assay show outstand sensit select low methyl dna distinguish moreov later flow assay also introduc exploit point care diagnost platform import propos method show high sensit determin genom dna methyl cancer cell indic great potenti tumor specif gene analysi | D064130 | T123;T116 |
36,214,814 | phosphorothio phosphat termin dumbbel pp td probe base rapid detect polynucleotid kinas activ polynucleotid kinas pnk bifunct enzym kinas phosphatas activ play import role dna repair associ various diseas develop primer free sensit isotherm quantit assay detect pnk activ presenc pnk phosphat group substrat digest oh initi amplif reaction elong dsdna bind dsdna specif fluoresc dye evagreen lead signific enhanc fluoresc intens limit detect lod method u l compar even superior previous report method approach also show good quantit abil complex cell lysat indic potenti biolog sampl analysi addit facil sensit assay use screen pnk inhibitor propos method provid promis platform sensit pnk activ monitor inhibit screen drug discoveri clinic treatment | D011116;D015374 | T059;T075;T126;T116 |
36,214,813 | eat away cell respons lung cancer despit evid clinic benefit patient suffer lung cancer follow treatment immun checkpoint inhibitor ici still uncertain predict patient like experi signific respons work valencia et al j exp medhttp doiorgjem identifi dstyk kinas cancer cell intrins modul respons immunotherapi regul mtor pathway stimul protect autophagi dstyk blunt cd cell mediat kill cancer cell accord lung cancer increas express dstyk less respons ici treatment observ could use clinic toward develop predict biomark novel therapeut strategi | D000082082;D008175 | T121;T191;T043;T129 |
36,214,811 | fabric heterojunct coupl metal organ framework n dope carbon photocatalyt remov antibiot drug high effici norfloxacin tetracyclin tc two wide use antibiot drug releas aquat environ induc harm ecosystem studi effect method develop success remov tc photocatalysi novel heterojunct ncnh mil fe fabric combin metal organ framework mof materi nh mil fe n dope carbon nc nanoparticl via facil solvent thermal method prepar product exhibit outstand photocatalyt effici toward degrad tc time higher pure nh mil fe respect moreov higher relat materi report previous great enhanc photocatalyt perform assign fabric heterojunct well match energi band gap nc act effici electron transferreservoir materi effect promot migrat transfer restrain recombin charg carrier addit form heterojunct increas specif surfac area light absorb photocatalyt activ enhanc mechan degrad product pathway investig present studi offer novel strategi signific improv photocatalyt perform mof high effici photocatalyt remov antibiot drug wastewat | D000073396 | T109 |
36,214,808 | cultur independ raman spectroscop identif bacteri pathogen clinic sampl use deep transfer learn rapid identif bacteri pathogen clinic sampl like blood urin pus sputum need hour convent bacteri identif method like cultur nucleic acid base amplif limit like poor sensit high cost slow turnaround time etc raman spectroscopi label free noninvas techniqu overcom drawback provid rapid biochem signatur singl bacterium raman spectroscopi combin chemometr method use effect identifi pathogen howev robust approach need util raman featur accur classif deal complex data set spectra obtain clinic isol show high sampl sampl heterogen studi use raman spectroscopi base identif pathogen clinic isol use deep transfer learn approach singl cell level resolut use data augment method increas volum spectra need deep learn analysi resnet model could specif extract spectral featur eight differ pathogen bacteri speci classif accuraci robust model valid set blind data set mix cultur noncultur bacteri isol various origin type propos resnet model effici identifi pathogen blind data set high accuraci provid robust rapid bacteri identif platform clinic microbiolog | D013059;D009696 | T059;T123;T114;T070 |
36,214,790 | synthet benign one pot construct enamino xanthen dye polyhydroxyl phenol compon biomass precursor pigment plant paper report novel entri xanthen dye involv reaction trihydroxybenzaldehyd primari aliphat amin catalyst free synthesi exhibit high atom economi conduct eco friend condit oper simplic | D004396;D000588 | T109;T130;T197 |
36,214,788 | accuraci radiograph diagnosi pneumoperitoneum secondari gastrointestin perfor dog cat radiographi common includ diagnost investig anim suspect gastrointestin perfor result pneumoperitoneum studi aim identifi accuraci radiograph diagnosi pneumoperitoneum determin observ experi affect accuraci | D011027;D002371;D004283 | T047 |
36,214,784 | presynapt rac control synapt strength regul synapt vesicl prime synaps contain limit number synapt vesicl svs releas respons action potenti ap therefor sustain synapt transmiss wide rang ap fire rate timescal depend sv releas replenish although actin dynam impact synapt transmiss presynapt regul actin signal cascad control sv releas replenish remain unresolv rac rho gtpase regul actin signal cascad control synaptogenesi neuron develop postsynapt function howev presynapt role rac regul synapt transmiss unclear unravel rac role control transmitt releas perform select presynapt ablat rac matur mous calyx held synaps loss rac increas synapt strength acceler epsc recoveri condit stimulus train augment spontan sv releas chang presynapt morpholog az ultrastructur analys constrain short term plastic model reveal faster sv prime kinet depend model assumpt elev sv releas probabl higher abund tight dock fusion compet svs rac defici synaps conclud presynapt rac key regul synapt transmiss plastic main regul dynam sv prime potenti sv releas probabl | D013572;D000199 | T026;T123;T116 |
36,214,781 | differ surgic outcom glaucoma surgeri patient african caribbean descent peopl african caribbean descent acd higher preval glaucoma compar peopl european descent ed uncertainti treatment outcom equival two group assess surgic failur rate compar acd ed focus trabeculectomi aqueous shunt implant non penetr filter surgeri npfs minim invas glaucoma surgeri mig perform systemat review accord prisma guidelin determin whether evid show differ success rate base race | D014130;D005901 | T061;T047 |
36,214,779 | phorbolest activ munc ubmunc exert oppos effect dens core vesicl secret munc protein prime factor snare depend exocytosi activ diacylglycerol dag bind c domain sever munc paralog exist differenti role well understood studi interdepend phorbolest dag mimic munc ubmunc mous adren chromaffin cell although express either munc ubmunc stimul secret phorbolest stimulatori secret ubmunc express domin inhibitori munc domin accord phorbolest stimul secret wildtyp cell cell overexpress ubmunc inhibit secret munc uncb knockout ko cell cell overexpress munc phorbolest stimulatori munc unca ko wt litterm show endogen munc limit effect phorbolest imag show ubmunc traffic plasma membran time cours match ca depend secret traffick independ synaptotagmin syt howev absenc syt phorbolest becam inhibitori munc ubmunc driven secret indic stimulatori phorbolest x munc interact depend function pair syt overal dagphorbolest ubmunc syt form stimulatori triad dens core vesicl prime | D004075;D010703 | T121;T131;T109;T123 |
36,214,771 | control surfac contact oxygen transport pit surfac oxid via singl channel scan electrochem cell microscopi singl channel scan electrochem cell microscopi appli potenti approach micropipett substrat generat transient current upon droplet contact substrat transient current exceed set threshold micropipett automat halt current effect approach potenti subsequ electrochem measur open circuit potenti potentiodynam polar consid inconsequenti herein demonstr appli approach potenti impact extent probe substrat interact subsequ microscal electrochem measur aluminum alloy aa | D008853;D010087 | T059;T197 |
36,214,770 | renew vanillin base thermoplast polybutadien rubber high strength recycl self weld shape memori antibacteri properti vast major tradit vulcan rubber product insolubl infus difficult reprocess biodegrad result black pollut addit although rubber materi base coval adapt network can achiev structur reconstruct lack tradit vulcan system lead declin strength studi biobas vanillin deriv pv synthes cross link commerci avail polybutadien rubber precursor construct imin base can therebi fabric resourc renew recycl degrad high perform rubber materi due rigid tripod structur pv tensil strength materi achiev high mpa rank among best field recycl polybutadien base materi benefit dynam imin unit dynam coval bridg establish repair damag network endow materi excel weldabl shape memori faculti materi prove depict moreov materi display excel antibacteri properti origin introduc schiff base structur mix graphen applic action sensor also achiev | D014896;D006108 | T057;T196;T109 |
36,214,767 | pseudogen ubemp deriv transcript enhanc vitro cell prolifer apoptosi resist hepatocellular carcinoma cell mir prgs axi pseudogen bare transcrib normal anomal transcript most regard long non code rnas lncrnas play potenti function human tumorigen develop exact effect pseudogen deriv transcript hepatocellular carcinoma hcc ambigu accord previous research construct databas hcc relat lncrnas notic ubemp transcript activ hcc pseudogen ubiquitin conjug enzym member ubem studi valid high express ubemp transcript hcc advers correl dismal outcom patient ubemp deplet transcript level signific impair cell prolifer apoptosi resist hcc cell line notabl discov ubemp transcript share specif sequenc bind mir p seed region typic cerna effect simultan verifi axi mir prgs hcc cell promot cell prolifer apoptosi resist signific modul uemp could remark affect rgs express consequenti influenc hcc cell growth vitro combin rescu experi modul either mir p rgs further indic ubemp upstream regul axi promot hcc cell growth mainten thus find provid new strategi hcc prevent individu treatment | D006528;D062085;D008113;D035683;D020710 | T191;T123;T116;T114 |
36,214,762 | erap potenti biomark predict gemcitabin respons patient pancreat cancer pancreat cancer one malign tumor rapid metastasi high mortal rate difficult earli screen current gemcitabin first line drug pancreat cancer patient clinic effect limit due drug resist particular import identifi biomark associ gemcitabin resist improv sensit gemcitabin treatment | D019008;D010190 | T038;T042;T191 |
36,214,757 | atomist pictur boron oxid catalyst oxid dehydrogen reveal ultrahigh field b solid state nmr spectroscopi boron oxidehydroxid support oxid activ carbon boac shown inexpens catalyst oxid dehydrogen odh propan offer activ select compar boron nitrid obtain atomist pictur boron oxidehydroxid layer boac use b solid state nmr experi nmr spectra measur resolv boron oxygen site due narrow central transit powder pattern b dipolar heteronuclear correl nmr spectrum reveal structur connect boron oxygen atom approach outlin general applic determin atomist structur heterogen catalyst contain quadrupolar nuclei | D001895;D011407 | T109;T196 |
36,214,754 | dynam modul sphingolipid glycerophospholipid covid heterogen clinic phenotyp characterist coronavirus diseas covid therefor investig biomark associ diseas sever import understand mechan respons heterogen develop novel agent prevent critic condit studi aim elucid modul sphingolipid glycerophospholipid shown possess potent biolog properti | D000086382;D013107 | T047;T109;T067 |
36,214,750 | generat carbon radic via hydrogen atom transfer synthesi bridg nucleosid rapid facil generat carbon radic oxim imid nucleosid via hydrogen atom transfer induc iminyl radic develop cyclize carbon radic olefin follow hydrolysi imid residu provid various c c bridg nucleosid oper simpl approach appli step synthes methyl c ethylen bridg methyluridin ena constrain ethyl bridg methyluridin cet | D009705;D006859 | T121;T196;T114 |
36,214,741 | one hundr carboxyl receptor work present compil bind constant log k ass valu dmso h mm varieti receptor carboxyl anion format acet lactat pival sorbat hexano benzoat glyphos glucuron ibuprofen naproxen ketoprofen total log k ass valu list anion receptor molecul log k ass valu origin previous publish articl along valu previous unpublish receptor molecul span workflow year purpos studi serv comprehens inform sourc select suitabl receptor candid use practic carboxyl sens applic construct ion select electrod ise support decis make receptor present togeth lipophil log p ow data | D007660 | T121;T109 |
36,214,740 | stimuli respons imag guid nanocarri smart drug deliveri platform recent year improv precis drug deliveri reduc toxic associ uncontrol drug releas target locat extens effort paid develop stimuli respons nanocarri enabl precis control demand drug releas due intern stimuli like ph redox enzym extern stimuli like light magnet field ultrasound moreov stimuli respons nanocarri strateg incorpor imag probe simultan monitor drug deliveri process region interest treatment optim | D004337;D053758 | T073;T122 |
36,214,733 | palladium catalyz thiocarbonyl aryl iodid aryl thioform via thioester transfer herein report novel approach synthes thioester aryl thioform thioester sourc reaction proceed ambient temperatur use wide avail start ingredi wherein thioester moieti smooth transfer aryl iodid aryl thioform varieti substrat various electron natur toler reaction condit furnish desir thioester rang moder excel yield gram scale reaction also conduct virtual littl chang chemic yield indic larg scale synthesi thioester may viabl use method | D010165;D007454 | T196;T197 |
36,214,703 | corner flow induc surfact produc bacteria bacillus subtili pseudomona fluorescen mechanist understand bacteri spread soil air water angular pore space critic control pathogen contamin soil design bioremedi project recent studi j q yang j e sanfilippo n abbasi z gitai et al proc natl acad sci u e https doiorgpna show pseudomona aeruginosa self generat flow along sharp corner produc rhamnolipid type biosurfact chang hydrophob solid surfac hypothes type biosurfact biosurfact produc bacteria also generat corner flow first demonstr rhamnolipid surfactin biosurfact differ chemic structur generat corner flow identifi critic concentr two biosurfact generat corner flow second demonstr two common soil bacteria pseudomona fluorescen bacillus subtili produc rhamnolipid surfactin respect generat corner flow along sharp corner speed sever millimet per hour show surfactin defici mutant b subtili generat corner flow third show similar find p aeruginosa critic corner angl p fluorescen b subtili generat corner flow predict classic corner flow theori final show height corner flow limit round corner result suggest biosurfact induc corner flow preval soil consid model predict bacteri spread soil critic biosurfact concentr identifi mathemat model propos provid theoret foundat futur predict bacteri spread soil import spread bacteria soil critic soil biogeochem cycl soil groundwat contamin effici soil base bioremedi project howev mechanist understand bacteri spread soil remain incomplet due lack direct observ simul confin space hydrocarbon cover soil use transpar materi similar hydrophob visual spread two common soil bacteria pseudomona fluorescen bacillus subtili show bacteria generat corner flow veloc sever millimet per hour produc biosurfact soap like chemic provid quantit equat predict critic corner angl bacteri corner flow maximum distanc corner spread anticip bacteri corner flow preval biosurfact produc bacteria angular pore common soil result help improv predict bacteri spread soil facilit design soil relat bioremedi project | D001412;D011551 | T007 |
36,214,702 | metatranscriptom reveal divers tick virom northwest china blood suck tick oblig parasit vector varieti human anim virus tick born virus identifi pathogen infecti diseas human anim potenti impos signific public health burden threat husbandri industri therefor identifi profil tick born virus provid valuabl inform evolut pathogen ecolog tick born virus studi investig virom parasit tick collect bodi surfac herbivor xinjiang uyghur autonom region inner mongolia autonom region china two region northwest china use metatranscriptom approach rna virus high divers genom organ evolut identifi among nine propos novel speci classifi virus belong six viral famili includ phenuivirida rhabdovirida peribunyavirida lispivirida chuvirida reovirida unclassifi virus also identifi addit although virus differ sampl locat share signific similar abund divers virus notabl vari among differ collect locat studi demonstr divers tick born virus xinjiang inner mongolia provid inform data studi evolut pathogen rna virus import tick wide distribut pastor area northwestern china act vector carri transmit varieti pathogen especi virus studi reveal divers tick virus xinjiang inner mongolia uncov phylogenet relationship rna virus especi import zoonot tick born sever fever thrombocytopenia syndrom virus inner mongolia data suggest complex divers evolutionari histori potenti ecolog factor associ pathogen virus pathogen tick born virus current remain unclear therefor futur research focus evalu transmiss pathogen tick born virus | D013987;D016856;D012328;D014780;D017282 | T047;T005;T204 |
36,214,699 | lactococcus lacti effect intestin microbiota streptococcus agalactia infect zebrafish danio rerio streptococcus agalactia common pathogen aquacultur disrupt balanc intestin microbiota threaten fish health caus enorm loss aquacultur industri studi isol screen lactococcus lacti kust llk strain antibacteri effect agalactia vitro use potenti probiot explor therapeut effect zebrafish danio rerio infect agalactia studi divid zebrafish group control group inject phosphat buffer salin infect group inject agalactia treatment group treat llk agalactia inject rrna gene sequenc intestin microbiota group sequenc use illumina high throughput sequenc technolog result show relat abund intestin bacteria signific decreas infect group high relat abund agalactia observ relat abund intestin microbiota increas treatment group decreas relat abund agalactia compar control group cluster ortholog group protein function classif relat abund biolog function infect group signific lower control treatment group show llk posit therapeut effect zebrafish infect agalactia studi provid foundat explor pathogen mechan agalactia fish intestin symbiont also present new approach treatment agalactia infect fish aquacultur system import l lacti kust llk bacteriostat effect agalactia isol tilapia intestin tract agalactia infect signific reduc relat abund intestin bacteria various physiolog function zebrafish intestin llk demonstr infect subsequ therapeut effect agalactia infect zebrafish intestin therefor potenti probiot llk consid therapeut treatment agalactia infect aquacultur reduc use antibiot help maintain fish health | D013294;D000069196;D005393 | T007;T001;T047 |
36,214,697 | stem loop tembusu virus untransl region respons viral host specif adapt pathogen virus mice tembusu virus tmuv avian mosquito born flavivirus first identifi culex tritaeniorhynchus valid effect untransl region utr viral host specif adapt generat set chimer virus use cqw duck strain mm mosquito strain backbon heterogen utr compar rmm rmm cqutr recombin mm virus carri utr cqw exhibit enhanc prolifer vitro peak titer increas fold duck embryon fibroblast def cell fold babi hamster kidney bhk cell howev neurovirul rmm cqutr attenu day old kunm mice via intracrani inject slower weight loss lower mortal reduc viral load contrast rcq mmutr show similar growth kinet vitro neurovirul mice compar rcqw stem loop sli structur show highest variat within utr cqw mm chosen make chimer virus peak titer rmm cqutrsli display fold increas vitro neurovirul mice attenu compar rmm rcq mmutrsli display compar multipl abil vitro signific attenu mice contrast rcqw conclus demonstr tmuv sli structur utr respons viral host specif adapt mosquito deriv strain def bhk cell regul viral pathogen day old mice provid new understand function tmuv utr viral host switch pathogen chang mice import mosquito born flavivirus mbfvs constitut larg number mosquito transmit virus untransl region utr mbfv suggest relev viral host specif adapt howev evolutionari strategi host specif fit among mbfv differ virul relat structur within utr larg unknown use tembusu virus tmuv avian mbfv model observ duck deriv sli utr signific enhanc prolifer abil mosquito deriv tmuv babi hamster kidney bhk duck embryon fibroblast def cell suggest sli structur crucial viral host specif adapt mosquito deriv tmuv mammalian avian cell addit sli mutant virus exhibit reduc viral pathogen mice indic sli structur key factor pathogen mice studi provid new insight function mbfv utr viral host switch pathogen chang mice | D018177;D005416;D009033 | T047;T005;T204 |
36,214,695 | transmiss drug resist genotyp multidrug resist rifampicin resist mycobacterium tuberculosi chongq china multidrug resist rifampicin resist tuberculosi mdrrr tb global barrier stop tb plan identifi risk factor treatment outcom cluster transmiss mdrrr tb whole genom sequenc wgs data isol patient chongq tuberculosi control institut use phylogenet classif resist predict cluster analysi total mdrrr tb case record januari decemb elder patient lung cavit increas risk death due mdrrr tb total mdrrr strain obtain wgs data classifi lineag strain eighti strain differ distanc fewer singl nucleotid polymorph classifi genom cluster indic recent transmiss patient infect lineag strain occup list signific associ transmiss cluster mdrrr tb analysi resist mutat first line tuberculosi drug found strain mutat within cluster total mdrrr tb strain accumul addit drug resist mutat along transmiss chain especi fluoroquinolon recent transmiss mdrrr strain drive mdrrr tb epidem lead accumul serious resist along transmiss chain import drug resist molecular characterist mdrrr tb elucid genom wide analysi risk factor death mdrrr tb identifi combin patient inform cluster characterist mdrrr tb region analyz genom wide analysi risk factor cluster transmiss recent transmiss analyz analys provid refer prevent treatment mdrrr tb chongq | D009169;D018088 | T007;T047 |
36,214,694 | singl point mutat role specif pathogen reveal mechan relat protein famili pyolysin plo secret trueperella pyogen water solubl monom form transmembran barrel channel cell membran bind cholesterol two signific conserv residu domain plo mutat provid novel evid relationship conform chang interact cell membran uncov pore format mechan cholesterol depend cytolysin cdc famili moreov plo special member cdcs percentag sequenc ident plo cdc member other usual import understand low sequenc ident model differ pathogen mechan cdc member dedic larg number gram posit bacteri pathogen studi first time locat mutat two differ high conserv structur site primari structur critic plo structur function prove import site togeth novel repeat observ pore format mechan cdcs provid find import postpartum diseas dairi cow caus persist bacteri infect global diseas serious impact develop dairi industri bring huge econom loss one relev pathogen bacteria postpartum diseas dairi cow trueperella pyogen secret pyolysin plo member cholesterol depend cytolysin cdc famili recogn import toxin pyogen howev current research work plo still insuffici pathogen mechan toxin fulli explor chang local structur overal function toxin previous unidentifi singl point mutat studi lay groundwork futur studi explor contribut larg famili cdc protein microbi surviv human diseas | D017354;D001426 | T123;T116;T049 |
36,214,691 | gut testi axi microbiota prime metabolom increas sperm qualiti young type diabet young type diabet td affect popul note increas case td relat male infertil becom serious issu recent year current studi aim explor improv algin oligosaccharid ao modifi gut microbiota semen qualiti td td establish young mice week age blood glucos level mmoll blood glucos mm control anim discov fecal microbiota transplant fmt ao improv microbiota fmt signific decreas blood glucos fmt gut microbiota control anim con fmt sperm concentr motil decreas td control group fmt brought recoveri around fold fmt signific increas small intestin allobaculum elev small intestin cecal lactobacillus extent blood butyr acid deriv eicosapentaeno acid epa testicular docosahexaeno acid dha epa testosteron deriv furthermor fmt improv liver function system antioxid environ import fmt promot spermatogenesi improv express protein import spermatogenesi increas sperm concentr motil under mechan may fmt increas gut benefici microb lactobacillus allobaculum elev blood andor testicular butyr acid dha epa testosteron promot spermatogenesi thus amelior sperm concentr motil ao improv gut microb could emerg attract candid treat td diminish semen qualiti import fmt benefit gut microbiota liver function system environ via improv blood metabolom consequ favor testicular microenviron improv spermatogenesi process boost td diminish semen qualiti establish ao improv gut microbiota may use boost td decreas semen qualiti metabol diseas relat male subfertil | D003924;D000069196 | T007;T001;T047 |
36,214,685 | screen spore form bacteria probiot potenti pristin algerian cave interest explor biodivers subsurfac ecosystem increas signific last decad aim studi investig vitro probiot properti spore form bacteria isol deep cave two hundr fifti spore form microb enrich sediment sampl differ pristin cave algeria differ depth isol show nonpathogen profil screen potenti produc digest enzym gliadinas beta galactosidas solid liquid media respect differ probiot potenti studi includ growth c ii surviv simul gastric juic iii surviv simul intestin fluid iv antibiot sensit cell surfac properti result show isol isol demonstr nonpathogen charact probiot potenti abil hydrolyz gliadin lactos solut find suggest select cave microb might serv sourc interest candid probiot import previous microbi studi subsurfac ecosystem like cave focus main natur biodivers system far studi focus biotechnolog potenti microb system focus particular antibacteri potenti antibiot product extent enzymat potenti studi explor whether subsurfac ecosystem serv altern sourc microb relev probiot research focus abil cave microb degrad two substrat lactos gliadin caus common digest disord sinc enzym may prove use food process reduc effect lactos gliadin digest within intoler patient isol microb studi may expand possibl develop altern strategi deal intoler | D005903;D019936 | T007;T123;T116 |
36,214,684 | essenti function calmodulin identif proxim interact protein tachyzoit stage toxoplasma gondii via bioid technolog toxoplasma gondii gondii pathogen belong apicomplexan phylum threaten human anim health calcium ion critic second messeng cell regul import biolog process includ parasit invas egress calmodulin cam small high conserv ca bind protein found eukaryot cell bind ca cam activ interact various protein howev littl known cam function interact protein gondii studi success knock cam gondii parent strain tati use tetracyclin system toxoplasma cam promot result indic cam requir tachyzoit prolifer invas egress cam deplet result apicoplast loss thus threaten parasit surviv next lytic cycl tachyzoit stage cam loss caus signific anomali parasit basal constrict motil parasit rosett like arrang parasitophor vacuol pv phenotyp defect caus cam deplet indic import cam gondii therefor import identifi cam interact protein gondii appli bioid technolog cam proxim interact protein identifi gondii cam partner broad distribut throughout parasit furthermor protein interactom transcriptom analys indic potenti role cam ion bind cation bind metal ion bind calcium ion bind oxid reduct find shed light cam function cam interactom gondii eukaryot import toxoplasma gondii intracellular pathogen threaten human anim health unicellular parasit activ mani biolog process egress invas implement effici gondii biolog process depend signal transmiss ca second messeng essenti parasit life cycl calmodulin ubiquit ca receptor protein high conserv mediat numer ca depend event eukaryot cam function regul partner character gondii tachyzoit report essenti function calmodulin gondii tachyzoit identif interact partner use bioid technolog shed light cam function cam interactom toxoplasma gondii eukaryot | D014122;D010271 | T204 |
36,214,682 | new hiv k e revers transcriptas variant associ rapid expans crfbc among men sex men hiv crfbc origin among inject drug user idus china diffus men sex men msm crfbc shown rapid expans group howev mechan remain unclear identifi new k e variant crfbc character five specif mutat ek ke ev kq ts revers transcriptas variant main preval among msm overrepres transmiss cluster suggest could driven rapid expans crfbc msm though founder effect rule descend evolutionari intermedi accumul four specif mutat form independ phylogenet node estim origin time k e variant demonstr signific higher vitro hiv replic abil wild type mutat ek ke play critic role improv vitro hiv replic abil reflect improv revers transcript activ result could allow public health offici use marker especi ek ke mutat revers transcriptas rt code region target prevent measur priorit msm popul person infect variant test treat initi import hiv high mutat rate correl surviv adapt virus variant higher transmiss may select advantag strain higher virul sever hiv variant previous demonstr correl higher viral load lower cd cell count first identifi new variant k e variant hiv crfbc describ origin evolutionari dynam demonstr higher vitro hiv replic abil wild type demonstr five rt mutat especi ek ke signific improv vitro hiv replic abil appear new k e variant associ rapid increas preval crfbc among msm | D015497;D015658;D000072339 | T098;T047;T005 |
36,214,681 | role enzymat activ biolog cost associ product ampc lactamas pseudomona aeruginosa current scenario grow antibiot resist understand interplay resist mechan biolog cost crucial design therapeut strategi regard intrins ampc lactamas hyperproduct probabl import resist mechan pseudomona aeruginosa proven entail import biolog burden attenu virul most peptidoglycan recycl alter p aeruginosa acquir resist new lactam lactamas inhibitor combin ceftazidim avibactam ceftolozan tazobactam mutat affect ampc regulatori gene impact mutat associ biolog cost role lactamas activ play per se contribut mention virul attenu unknown question remain unsolv plasmid encod ampc type lactamas fox enzym also provid resist new lactam lactamas inhibitor combin assess differ perspect effect chang activ center thus hydrolyt spectrum resist inhibitor ampc type lactamas fit virul p aeruginosa use site direct mutagenesi previous describ ampc variant ti gd g e final bla fox versus bla fox result indic essenti role ampc activ per se caus report full virul attenu term growth motil cytotox galleria mellonella larva kill although biolog cost mention ampc type variant similar wild type enzym suggest import biolog burden may limit selectionspread variant could progress compromis futur effect mention drug combin import grow antibiot resist top nosocomi pathogen pseudomona aeruginosa push research explor new therapeut strategi resist versus virul balanc promis sourc target resist often entail signific biolog cost littl known base virul attenu associ resist mechan extraordinarili relev lactamas product demonstr besid potenti energi cell wall alter enzymat activ p aeruginosa cephalosporinas ampc essenti caus full attenu associ hyperproduct affect differ featur relat pathogenesi fact exploit antivirul perspect less encourag also show product differ chromosomalplasmid encod ampc deriv confer resist newest antibiot combin caus signific increas biolog burden suggest free way selectionspread type variant potenti compromis futur effect antipseudomon therapi | D011550;D011552 | T007;T047 |
36,214,678 | chang arbuscular mycorrhiz fungal communiti glomalin rhizospher along distribut gradient zonal stipa popul across arid semiarid stepp arbuscular mycorrhiz fungi amf report wide distribut terrestri ecosystem play vital role ecosystem function symbiosi stipa grass howev exact amf communiti rhizospher chang distribut along differ stipa popul substitut distribut relationship remain unclear chang distribut rhizospher amf communiti associ host dynam differ glomalin relat soil protein grsp rhizospher soil seven stipa speci spatial substitut distribut characterist arid semiarid grassland investig along substitut distribut stipa popul communiti structur taxa speci number alpha divers index valu amf rhizospher chang amf taxa appear certain stipa speci obvious amf taxon turnov stipa baicalensi popul replac stipa gobica popul grsp tend declin wherea carbon contribut grsp tend increas stipa grandi stipa krylovii great degre network modular rhizospher amf communiti exhibit simpl unstabl network structur network stipa breviflora complex compact high stabl furthermor success zonal popul plant speci veget coverag climat gradient facilit differenti amf communiti structur quantiti rhizospher differ stipa speci find present novel insight ecosystem function dynam correl chang environ import studi fill gap understand soil arbuscular mycorrhiz fungal communiti distribut communiti composit chang divers stipa speci along differ stipa popul substitut distribut adapt relationship furthermor differ glomalin relat soil protein grsp content rhizospher differ stipa speci grsp contribut grassland organ carbon pool investig find provid theoret basi protect util region biodivers resourc sustain ecosystem develop | D038821;D000072761 | T004 |
36,214,677 | isol extens drug resist pseudomona aeruginosa exo strain belong high risk clone st coproduc ndm novel vim aim studi investig genom featur extens drug resist xdr pseudomona aeruginosa isol p emerg chile antibiot suscept determin disk diffus colistin agar test whole genom sequenc wgs perform illumina nextseq platform epidemiolog clinic relev data ie sequenc type serotyp mobil genet element virulom resistom plasmidom prophag crispr cas system retriev use multipl bioinformat tool p strain display xdr profil remain suscept colistin genom analysi reveal isol belong high risk clone st cc serotyp genotyp exo strike two crispr cas system five intact prophag sequenc broad resistom includ bla ndm novel bla vim carbapenemas gene predict result reveal genom characterist p aeruginosa belong high risk clone sto coproduc ndm vim chile support genom surveil necessari track emerg spread epidemiolog success critic prioriti pathogen order prevent rapid dissemin | D011550;D011552 | T007;T047 |
36,214,676 | identif arginin phosphoryl mycolicibacterium smegmati tuberculosi lead caus worldwid infecti mortal preval multidrug resist mycobacterium tuberculosi infect drive urgent need exploit new drug target one target atp depend proteas clpcpp strict essenti viabil howev proteolyt substrat mycobacteri clpcpp identifi date recent studi bacillus subtili shown ortholog clpcp proteas recogn proteolyt substrat bear posttransl arginin phosphoryl sever line evid suggest clpcpp similar capabl recogn phosphoarginin bear protein exist phosphoarginin modif mycobacteria remain question confirm presenc posttransl phosphoarginin modif mycolicibacterium smegmati nonpathogen surrog tuberculosi use phosphopeptid enrich workflow coupl shotgun phosphoproteom identifi arginin phosphosit sever function divers target within smegmati proteom interest phosphoarginin modif upregul heat stress suggest diverg role mycobacteria bacillus find provid new evid support exist phosphoarginin mediat proteolysi clpcpp mycobacteria actinobacteri speci import mycobacteria caus tuberculosi infect employ proteolyt pathway modul cellular behavior destroy specif protein high regul manner proteolyt enzym emerg novel antibacteri target drug resist tuberculosi infect howev limit understand enzym function cell select protein destruct proteolyt enzym capabl recogn protein carri unusu chemic modif arginin phosphoryl confirm exist arginin phosphoryl mycobacteri protein work expand understand promis drug target import global pathogen | D009169;D014376 | T007;T047 |
36,214,673 | updat databas acinetobact baumannii capsular polysaccharid locus type extend extens divers repertoir gene found outsid k locus sever novel non antibiot therapeut critic prioriti bacteri pathogen acinetobact baumannii reli specif cell surfac capsular polysaccharid cps henc predict cps type deduc gene whole genom sequenc data underpin develop applic therapi studi provid comprehens updat baumannii k locus refer sequenc databas cps type avail kaptiv v includ new kl provid total kl refer sequenc databas also reconfigur compat updat kaptiv v code enabl predict k type special logic paramet defin detect combin kl addit gene outsid k locus valid databas public avail baumannii genom assembl ncbi databas identifi specif kl genom perfect high high confid poor sequenc qualiti presenc insert sequenc main reason lower confid level overal kl overrepres avail genom kl common follow relat kl kl substanti variat gene content central portion k locus usual includ gene specif cps type includ distinct group gene synthesi various complex sugar gene form linkag sugar ad non sugar substitu repertoir gene type found across kl found kl | D040981 | T007 |
36,214,669 | unrestrain growth correct orient microtubul instruct axon microtubul orient mani eukaryot cell direct molecular transport occur along microtubul within neuron axon transport vast distanc particular reli uniform orient microtubul whose plus end point toward distal axon tip anterograd polymer plus end howev axon microtubul initi mix orient orient develop yet fulli understood use live imag primari drosophila melanogast neuron found distal part axon catastroph rate plus end microtubul signific reduc compar minus end microtubul physic model reveal plus end microtubul therefor exhibit persist long term growth growth minus end microtubul limit lead bias overal axon microtubul orient use chemic physic perturb microtubul growth genet perturb anti catastroph factor p enrich distal axon tip confirm enhanc growth plus end microtubul critic achiev uniform microtubul orient comput simul axon develop integr enhanc plus end microtubul growth identifi previous suggest mechan dynein base microtubul slide augmin mediat templat correct predict long term evolut axon microtubul orient found experi studi thus lead holist explan axon microtubul orient uniform prerequisit effici long rang transport essenti neuron function | D004331;D004398 | T126;T123;T116;T204 |
36,214,665 | n myc downstream regul gene ndrg function molecular switch cellular adapt hypoxia lack oxygen hypoxia anoxia detriment cell function surviv under mani diseas condit henc metazoan evolv mechan adapt low oxygen one mechan metabol suppress decreas cellular demand oxygen downregul atp demand process howev molecular mechan under adapt poor understood report role ndrga hypoxia adapt anoxia toler zebrafish embryo ndrga express kidney ionocyt cell type use larg amount atp maintain ion homeostasi ndrga mutant viabl develop normal rais normal oxygen howev surviv kidney function reduc relat wt embryo follow exposur prolong anoxia demonstr ndrga bind energi demand sodium potassium atpas nka pump anoxia requir degrad may preserv atp kidney ionocyt contribut energi homeostasi last show sodium azid treatment increas lactat level normoxia suffici trigger nka degrad ndrga depend manner find support model wherebi ndrga essenti hypoxia adapt function downstream lactat signal induc nka degrad process known conserv cellular energi | D000860;D015027 | T046;T184;T013;T033 |
36,214,662 | global pangenom wheat fungal pathogen pyrenophora tritici repenti predict effector protein structur homolog adapt potenti plant fungal pathogen larg govern gene content speci consist core accessori gene across pathogen isol repertoir approxim complet gene repertoir global signific crop fungal pathogen pan genom analysi undertaken pyrenophora tritici repenti ptr causal agent tan yellow spot diseas wheat studi new ptr genom sequenc assembl annot includ isol three race previous sequenc togeth previous publish ptr genom pangenom ptr isol australia europ north africa america repres near known race reveal conserv core gene content present new ptr resourc search natur homologu orthologu acquir horizont transfer anoth speci use remot protein structur homolog identifi first time non synonym mutat ptr necrotroph effector gene toxb multipl copi inact toxb within isol distant natur pyrenophora homologu known parastagonopora nodorum necrotroph effector sntox clear genom break point toxa effector horizont transfer region comprehens genom analysi ptr race includ nine isol sequenc via long read technolog accord resourc provid complet represent speci serv resourc monitor variat potenti involv pathogen | D009183;D014908 | T002;T109;T131;T168 |
36,214,657 | c sp hc sp h dehydrogen radic coupl glycin deriv report general c sp hc sp h dehydrogen coupl strategi prepar various natur unnatur amino acid readili avail glycin deriv hydrocarbon combin set hat process | D005998;D000596 | T121;T123;T116 |
36,214,650 | splint non oper manag development dysplasia hip ddh children six month age development dysplasia hip ddh describ abnorm develop hip childhood rang complet disloc hip joint subtl immatur hip enloc stabl within socket ddh occur around per live birth though one per complet disloc variat treatment pathway ddh differ hospit even clinician within hospit variat relat sever dysplasia believ requir treatment techniqu use treat dysplasia | D000082602 | T047 |
36,214,648 | two step nuclear centr compet microtubul actin base mechan cell mous embryo microtubul typic promot nuclear centr earli embryon divis centrosom contain vertebr acentrosom mous zygot microtubul also centr male femal pronuclei prior first mitosi time concert actin nuclear centr brought subsequ acentrosom embryon divis studi use time laps imag mous embryo find although nuclei deliv cell centr upon complet first mitot anaphas major remain stationari instead travel way cortex microtubul depend manner high cytoplasm viscos cell embryo associ non diffus mechan involv actin subsequ nuclear centr microtubul exert negat influenc thus follow first mitot divis pro centr actin depend mechan work microtubul depend de centr forc disrupt equilibrium tug war compromis nuclear centr symmetri subsequ divis potenti risk embryon develop circuit centr process expos embryon vulner impos microtubul depend de centr forc | D000199;D008870 | T026;T123;T116 |
36,214,619 | phenotyp character isol myeloid deriv suppressor cell myeloid deriv suppressor cell mdscs heterogen popul immatur myeloid cell divid two main subpopul polymorphonuclear pmn mdscs monocyt mdscs cell accumul chronic inflamm induc immunosuppress evid array patholog cancer inflammatori bowel diseas infecti autoimmun diseas herein describ method isol character mdscs various murin tissu well phenotyp blood deriv mdscs patient protocol describ method isol total mdscs subpopul character evalu distribut within tissu well assess matur stage flow cytometri immunofluoresc analys giemsa stain author current protocol publish wiley period llc basic protocol singl cell suspens generat differ tissu altern protocol singl cell suspens generat subcutan melanoma tumor basic protocol character mdsc phenotyp basic protocol cell separ use magnet bead separ pan mdscs pmn mdsc mdsc subpopul altern protocol stain prepar mdscs sort support protocol pmn mdsc mdsc gate strategi mous basic protocol immunofluoresc analysi mdscs basic protocol handl human blood sampl character human mdscs altern protocol flow cytometri stain thaw human whole blood sampl | D000072737 | T025 |
36,214,609 | myc therapi resist cancer risk opportun myc transcript factor encod c myc proto oncogen activ growth promot signal key regul biosynthet metabol pathway drive cell growth prolifer process deregul myc driven tumor becom critic cancer cell prolifer surviv oncogen insult overexpress myc induc seri cellular stress metabol oxid replic etc collect known oncogen stress impact tumor progress also respons therapi profound multifacet consequ clinic outcom one hand recent evid uncov widespread role myc therapi resist multipl cancer type either standard chemotherapeut target regimen reciproc oncogen myc impart seri molecular metabol depend cell thus give rise cancer specif vulner may exploit obtain synthet lethal interact novel anticanc drug review current knowledg link myc therapeut respons discuss possibl strategi overcom resist new target intervent | D009369;D000970 | T191;T109;T121 |
36,214,608 | limit hesc patent china dual valu perspect chines patent law sever tool avail avoid patent thicket patent monopol chines patent law sever tool avail avoid patent thicket patent monopol limit right open licens compulsori licens measur ensur hesc relat patent optim use promot scientif research econom social develop | D000066449 | T025 |
36,214,606 | enantioselect total synthesi sieboldin analogu thereof step enantioselect total synthesi sieboldin accomplish r methylcyclohex en one intramolecular ketoneest reduct coupl follow one pot acid treatment quick construct uniqu oxa spiroacet tsoh catalyz displac direct form characterist n hydroxyazacyclononan ring success serv key methodolog moreov sever full skeleton analogu also synthes basi advanc intermedi inhibitori effect electr eel acetylcholinesteras examin | D000110;D007659 | T109;T126;T116 |
36,214,601 | photoinduc three compon carboaryl unactiv alken protic c sp h feedstock general mild strategi involv three compon carboaryl unactiv alken protic c sp h feedstock via photoredox catalysi report catalyt system compat broad rang unactiv alken cyano substitut aren divers protic c sp h feedstock synthet valu protocol demonstr late stage function complex molecul synthesi antiallergi includ pheniramin chlorpheniramin brompheniramin | D000475;D002744 | T121;T109 |
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