Javtor/biomedical-topic-categorization-validation

PMID int64 35.7M 36.4M	Title/Abstract stringlengths 22 8.78k	MeshTerms stringlengths 7 101	SemanticTypes stringlengths 4 64
36,317,351	type cervic disc herniat mri correl clinic outcom aim studi investig whether type cervic disc herniat influenc sever symptom time present outcom surgic treatment	D007405;D011843;D013123;D055959	T061;T047;T190;T037
36,317,350	combin high preoper pain low radiolog grade arthriti associ greater intens persist pain month total knee arthroplasti despit new technolog total knee arthroplasti tka approxim patient dissatisfi major reason dissatisfact revis surgeri tka persist pain radiolog grade osteoarthr oa preoper investig predictor outcom tka conflict result aim studi determin differ intens pain month tka relat preoper radiolog grade oa alon combin intens preoper pain radiolog grade oa	D019645;D020370	T061;T047
36,317,349	platelet rich plasma inject acut achill tendon ruptur two year follow path random placebo control superior trial determin whether platelet rich plasma prp inject improv outcom two year acut achill tendon ruptur	D000125;D013708;D053657;D016512	T023;T037;T031
36,317,348	distal tibial osteotomi compar proxim osteotomi limb lengthen children aim retrospect cohort studi assess investig safeti efficaci use distal tibial osteotomi compar proxim osteotomi limb lengthen children	D001852	T061
36,317,347	periprosthet joint infect next periprosthet joint infect pji remain extrem challeng complic focus issu last decad previous still mani unansw question workabl definit everyon align need continu focus identifi organ involv surgic strategi evolv care becom patient centr good studi way howev still numer problem resolv challeng pji remain major one orthopaed communiti annot provid date thought way forward still scope plenti research areacit articl bone joint j b	D016459;D019644;D019645;D001170	T061;T047;T046
36,317,346	arthroscop bicep augment improv clinic outcom incomplet repair larg massiv rotat cuff tear studi compar patient underw arthroscop repair larg massiv rotat cuff tear lmrcts isol incomplet repair tear patient incomplet repair bicep tendon augment aim evalu addit benefit clinic outcom capac lower tear rate	D000070636	T033;T047;T037
36,317,345	assess influenc modifi patient relat factor complic rate adult spinal deform surgeri postop complic rate remain relat high adult spinal deform asd surgeri extent modifi patient relat factor influenc complic rate patient asd effect evalu aim retrospect cohort studi evalu associ modifi patient relat factor complic correct surgeri asd	D013123;D010024	T061;T047
36,317,343	spinal versus general anaesthesia contemporari primari total knee arthroplasti spinal anaesthesia seen increas use contemporari primari total knee arthroplasti tkas howev controversi exist benefit spinal comparison general anaesthesia primari tkas studi aim investig pain control length stay los complic associ spinal versus general anaesthesia primari tkas singl high volum academ centr	D007720;D019645	T061;T074
36,317,342	cost util analysi surgic fixat kirschner wire versus cast fractur distal radius health econom evalu drafft trial aim studi compar cost effect surgic fixat kirschner k wire ersus mould cast manipul fractur distal radius oper theatr set	D050723;D011885	T037
36,317,327	editori recent approv sotorasib first target therapi kras gc mutat advanc non small cell lung cancer nsclc past two decad rapid advanc number rang regulatori approv target therapi patient advanc non small cell lung cancer nsclc cancer kirsten rat sarcoma viral oncogen homolog kras gene high mutat rate human cancer associ aggress type cancer includ nsclc pancreat ductal adenocarcinoma pdac colorect cancer crc recent sever common high aggress cancer kras mutat express death star kras protein consid undrugg amen target therapi main kras mutat singl base missens mutat occur codon gc kras gc common kras mutat nsclc sotorasib first class specif small molecul irrevers inhibit kras gc base result phase codebreak safeti toler studi may us food drug administr fda grant acceler approv sotorasib adult advanc nsclc kras gc mutat editori aim present current status regulatori approv support clinic trial data sotorasib first target therapi patient advanc nsclc kras gc mutat	D000970;D002289;D008175	T121;T191;T109
36,317,291	develop core outcom set hospit deprescrib trial older peopl care geriatrician half older peopl prescrib unnecessaryinappropri medic routin deprescrib hospit henc need deprescrib trial aim develop core outcom set cos deprescrib trial older peopl care geriatrician hospit admiss	D000072219;D000069340	T058;T170;T097
36,317,259	transgen schwann cell overexpress pouf promot sciatic nerv regener within acellular nerv allograft object acellular nerv allograft ana effect surgic approach use bridg sciatic nerv gap molecular regul post surgic recoveri well known explor effect transgen schwann cell scs overexpress pou domain class transcript factor pouf sciatic nerv regener within ana explor function pouf nerv regener use cell model h induc scs injuri transplant scs overexpress pouf ana repair sciatic nerv gap approach use rna seq protein protein interact network analysi gene ontolog enrich kyoto encyclopedia gene genom pathway analysi identifi high differenti express transcript factor pouf follow ana treatment sciatic nerv gap express high degre connect pouf predict play role peripher nervous system myelin main result test role pouf nerv regener ana infect scs adeno associ virus pouf demonstr pouf overexpress promot prolifer anti apoptosi migrat scs vitro also found pouf signific upregul jnk c jun phosphoryl select jnk inhibit attenu effect pouf prolifer surviv migrat jnk c jun phosphoryl direct interact pouf activ jnk subsequ confirm co immunoprecipit rat sciatic nerv injuri model mm gap confirm pattern pouf upregul co local transplant scs ana load pouf overexpress scs demonstr enhanc surviv transplant scs axon regener myelin function motor recoveri compar ana group load scs line vitro find signific studi identifi pouf novel regul post injuri sciatic nerv repair act jnkc jun signal scs optim therapeut outcom ana surgic approach	D020426;D059348	T047;T037
36,317,255	decod lexic tone vowel imagin tonal monosyl use fnir signal object speech common way communic decod verbal intent could provid naturalist communic way peopl sever motor disabl activ brain comput interact bci speller one common use speech bcis reduc spell time chines word identifi vowel tone embed imagin chines word essenti function near infrar spectroscopi fnir wide use bci portabl non invas safe low cost relat high spatial resolut approach studi activ bci speller base fnir present covert rehears tonal monosyl vowel ie u four lexic tone mandarin chines ie tone main result fnir result show signific differ right superior tempor gyrus imagin vowel tone tone ie activ stronger connect brain region imagin vowel tone tone speech relat area tone imageri ie right hemispher provid major inform identifi tone left hemispher advantag vowel identif decod vowel tone post stimulus period averag classif accuraci exceed multiclass ie four class binari set respect spell word quick time window size decod reduc classif accuraci signific reduc signific first time work demonstr possibl discrimin lexic tone vowel imagin tonal syllabl simultan addit reduc time window decod indic spell time chines word could signific reduc fnir base bcis	D013060;D013067	T041;T040;T054
36,317,248	feasibl cd base portabl xrf devic measur skin iron concentr anaem thalassaem patient iron essenti element vital growth develop sever effect bodi due iron defici overload prompt sustain research accur vivo iron measur techniqu past sever decad x ray fluoresc xrf analysi iron bodi investig work non invas natur techniqu system design use silicon drift detector measur low energi iron k x ray excit sampl silver x ray cd energi kev kev sourc contain within tantalum shield cap design reduc spectral background system calibr print polylact acid pla phantom fill solut iron various concentr iron x ray signal normal nickel x ray signal improv system reproduc phantom normalis result linear calibr line p real time measur minimum detect limit system measur ppm achiev low radiat dose msv skin surfac low detect limit low dose mean system feasibl applic human measur iron defici overload diseas system proceed post mortem valid studi prior vivo system efficaci test	D007501;D002104	T123;T196;T121;T131
36,317,246	segment geometri left coronari arteri coronari ct angiographi use deep learn hemodynam evalu coronari ct angiographi ccta crucial detect sever coronari arteri diseas fail provid essenti hemodynam paramet earli detect treatment paramet easili obtain perform comput fluid dynam cfd analysi arteri geometri generat ccta imag segment coronari arteri small size manual segment left coronari arteri ccta scan labori time intens error prone complic task also requir high level expertis academ recent propos various autom segment techniqu combat issu aid process present coronarysegnet deep learn base framework autonom accur segment well generat geometri left coronari arteri design base origin u net topolog includ channel awar attent block well deep residu block spatial dropout contribut featur map independ elimin featur map rather individu compon train test statist evalu model use ccta imag acquir various medic center across bangladesh rotterdam coronari arteri algorithm evalu challeng dataset improv general empir assess coronarysegnet outperform sever cut edg segment algorithm attain dice similar coeffici averag high signific p addit geometri generat machin learn semi automat method statist similar moreov hemodynam evalu perform geometri show compar result	D000072226;D000077321	T060;T066
36,317,231	fuzzi infer system fis long short term memori lstm network electromyographi emg signal analysi wide rang applic domain remot robot control rehabilit remot surgeri requir captur neuromuscular activ reliabl applic high depend abil decod intent accur base captur neuromuscular signal physiolog signal electromyographi emg electroencephalographi eeg generat neuromuscular activ contain intrins pattern user particular action action general classifi motor state forward revers hand grip hand releas classifi motor state truth signal must captur decod correct paper propos novel classif techniqu use fuzzi infer system fis long short term memori lstm network classifi motor state base emg signal exist emg signal classif techniqu general reli featur deriv data captur specif time instanc typic approach consid tempor correl signal entir window paper propos lstm fuzzi logic method classifi four major hand movement forward revers rais lower featur associ pattern generat throughout motor state movement extract explor publish data within given time window classif result achiev accuraci way action forwardreversegripupreldown forwardrevers action gripupreldown action way action propos mechan demonstr high level human interpret result employ rehabilit medic devic industri	D008570;D017143	T170;T041
36,317,229	characterist barrier facilit initi develop interprofession collabor rural remot primari healthcar facil scope review despit strong evid support interprofession collabor ipc document need collabor practic primari health care phc initi promot ipc rural remot phc facil extens studi purpos articl map interprofession educ ipe interprofession practic ipp initi implement promot ipc rural remot phc facil identifi barrier facilit implement	D007400;D003299	T054
36,317,226	associ air pollut csf strem cognit normal older adult cabl studi ambient air pollut aggrav process alzheim diseas ad patholog current exact inflammatori mechan under link clinic research remain larg unclear	D000544;D000397	T047;T080;T069;T048
36,317,221	para bombay phenotyp due bi allel heterozyg base delet fut gene explor genet mechan under case para bombay phenotyp	D000017;D005647	T185;T129;T116;T109;T126
36,317,220	associ gstp plce gene polymorph primari esophag cancer assess associ polymorph glutathion transferas p gstp phospholipas c epsilon plce gene suscept primari esophag cancer interact environment factor	D020022;D004938	T032;T191
36,317,219	associ genom instabl cdh gene clinicopatholog characterist gastric cancer assess associ genom instabl epitheli cadherin cdh gene clinicopatholog characterist gastric cancer	D013274	T191
36,317,218	analysi patient kallmann syndrom x xy karyotyp explor etiolog patient kallmann syndrom congenit hypogonad anosmia x xy karyotyp	D007006;D017436	T047
36,317,217	analysi clinic featur ebf gene variant child hypotonia ataxia development delay explor genet basi child featur hypotonia ataxia delay develop syndrom hadd	D008607;D009123	T033;T184;T047;T048
36,317,216	genet diagnosi child caf au lait macul juvenil xanthogranuloma explor genet basi child caf au lait macul juvenil xanthogranuloma	D009456;D014972	T047;T191
36,317,215	analysi novel compound heterozyg variant gja gene child congenit cataract explor genet basi child congenit cataract	D002386	T033;T047;T190
36,317,214	identif novel variant chines patient chediak higashi syndrom explor genet basi child featur chediak higashi syndrom chs	D002609	T047
36,317,213	analysi clinic featur genet variant chines pedigre affect famili adenomat polyposi analyz clinic featur genet basi chines pedigre affect famili adenomat polyposi fap	D025601;D011125	T123;T047;T191;T116
36,317,212	analysi clinic phenotyp genet variant chines pedigre affect cleidocrani dysplasia analyz clinic featur pathogen variant chines pedigre affect cleidocrani dysplasia ccd	D002973	T047
36,317,211	analysi hprt gene variant prenat diagnosi chines pedigre lesch nyhan syndrom specimen affect proband carri genet test prenat diagnosi chines pedigre lesch nyhan syndrom lns specimen affect proband	D007926	T047
36,317,210	clinic characterist genet analysi chines pedigre affect tuber sclerosi complex explor genet basi chines pedigre affect tuber sclerosi complex tsc	D014402	T191
36,317,209	analysi proc gene variant chines pedigre affect hereditari protein c defici explor molecular pathogenesi chines pedigre affect inherit protein c pc defici	D020151	T047
36,317,208	genet analysi prenat diagnosi chines pedigre affect bainbridg roper syndrom explor clinic featur genet basi child bainbridg roper syndrom brps	D002658;D008607	T048
36,317,207	analysi two chines pedigre affect alport syndrom due novel variant cola gene explor genet basi two chines pedigre affect alport syndrom	D009394	T047
36,317,206	multiplex pcr base sensit specif method detect chromosom materi patient turner syndrom develop multiplex pcr method rapid detect chromosom specif sequenc patient turner syndrom	D014424	T047
36,317,205	clinic signific serum mirna ox ldl ros express patient primari ovarian insuffici investig clinic signific mirna ox ldl ros patient primari ovarian insuffici poi	D035683;D016649	T123;T047;T114
36,317,204	analysi clinic featur genet variant three chines pedigre affect limb girdl muscular dystrophi type analyz clinic featur genet variant three chines pedigre affect limb girdl muscular dystrophi type lgmdi	D010430;D049288	T047;T126;T116
36,317,203	prenat diagnosi partial delet nrxn gene combin cnv seq qpcr assay summar genet diagnosi low depth copi number variat sequenc cnv seq prenat find fetus p delet involv nrxn gene	D015816;D056915	T045;T123;T116;T086
36,317,202	applic valu high throughput sequenc detect thalassemia ethnic li minor area assess valu high throughput sequenc detect thalassemia associ variant ethnic li minor area hainan china	D017085;D017086	T047
36,317,201	clinic evalu true fals posit z valu among high risk case screen non invas prenat test analyz z valu true fals posit case non invas prenat test nipt order improv accuraci clinic practic	D004314;D025063	T019;T047
36,317,200	clinic practic guidelin fragil x syndrom fragil x syndrom fxs common monogen form inherit intellectu disabl autism spectrum disord asd individu fxs caus unstabl expans cgg repeat locat within untransl region fmr gene clinic featur fxs includ various degre cognit deficit physic behavior psychiatr problem earli treatment prevent affect children guid molecular genet test fmr gene follow guidelin combin relev research guidelin consensus worldwid summar genet knowledg clinic treatment fxs order achiev standard diagnosi treatment prevent patient famili affect diseas	D000067877;D005600;D008607	T047;T048
36,317,185	cost effect singl versus multipl inhal tripl therapi uk copd popul intrepid trial week intrepid trial demonstr clinic benefit daili singl inhal tripl therapi sitt fluticason furoat umeclidinium vilanterol ffumecvi versus non ellipta multipl inhal tripl therapi mitt patient symptomat chronic obstruct pulmonari diseas copd analysi assess cost effect ffumecvi versus non ellipta mitt treatment symptomat copd unit kingdom uk nation health servic nhs perspect	D009330;D029424	T047;T074
36,317,184	effect hospit pharmacist intervent copd patient systemat literatur review logic model review aim summar empir evid pharmacist led intervent chronic obstruct pulmonari diseas copd patient hospit set identifi compon logic model includ input intervent output outcom contextu factor inform develop hospit pharmacist role copd manag	D010595;D029424	T047;T097
36,317,181	protocol high throughput screen sar cov main proteas inhibitor use robust fluoresc polar assay discoveri efficaci antivir agent target sar cov main proteas mpro highest import fight covid describ simpl protocol high throughput screen mpro inhibitor use robust fluoresc polar fp assay candid mpro inhibitor larg compound librari could rapid identifi monitor chang millipolar unit valu afford fp assay modifi screen antivir agent target virus proteas complet detail use execut protocol pleas refer li et al yan et al yan et al c	D057166;D000086382	T047;T059;T067
36,317,180	crispr cas induc gene knockout zebrafish applic crispr great facilit genotyp phenotyp studi human diseas model protocol describ crispr cas induc gene knockout zebrafish util purifi cas protein vitro transcrib sgrna protocol target phlpp gene indian wild caught strain broad applic major factor influenc protocol success includ zebrafish health fecund sgrna effici specif germlin transmiss mutant viabil complet detail use execut protocol pleas refer balamurugan et al	D015027;D064113	T040;T013
36,317,179	clone brd long isoform overexpress vector stabl overexpress brd l mammalian cell molecular clone brd l challeng techniqu dna insert form long gc rich sequenc fold secondari structur present protocol defin specif strategi amplifi brd l follow success clone gene overexpress vector sinc exist protocol commerci avail plasmid work provid use tool studi involv molecular clone brd l could potenti appli challeng gene	D005822;D009687	T123;T116;T114
36,317,178	protocol generat patient deriv xenograft model acquir resist immunotherapi human mice immunotherapi revolution cancer treatment preclin model requir understand immunotherapi resist mechan under patient relaps protocol describ generat acquir resist human vivo model immunotherapi patient deriv xenograft pdx detail step inject human cd cell nsg mice follow generat immunoresist pdx human mice approach recapitul human immun system allow investig generat preclin resist model differ immunotherapi identifi resist phenotyp complet detail use execut protocol pleas refer martnez sabadel et al arena et al	D007167	T061
36,317,177	high content live cell multiplex screen chemogenom compound annot base nuclear morpholog well character small molecul enabl studi cell process facilit target valid describ high content multiplex screen investig cell viabil h combin investig phenotyp featur tubulin bind mitochondri content initi cellular qualiti control divers compound protocol live cell basi easili adapt scalabl detail cell prepar compound handl plate layout configur imag acquisit cq data analysi use cellpathfind softwar complet detail use execut protocol pleas refer tjaden et al	D012984;D008928	T026;T090;T073;T170;T043
36,317,176	protocol atmospher water harvest use situ polymer honeycomb hygroscop polym atmospher water harvest awh offer solut effici extract water air protocol detail step develop composit sorbent load hygroscop salt lithium chlorid licl base hydrogel acrylamid monom carbon nanotub cnts describ streamlin experiment approach synthesi honeycomb optim hydrogel base composit adsorb pclg situ polymer produc sorbent exhibit ultra high adsorptiondesorpt capac per unit volum low temperatur desorpt complet detail use execut protocol pleas refer wang et al	D011108;D037742	T104;T122;T073
36,317,175	quantifi transport dynam three dimension singl particl track adher cell intracellular transport play import role maintain physiolog function cell describ protocol singl particl track within live cell detail use two focal imag system analyt step quantifi transport dynam protocol use character intracellular diffus traffick macromolecul nanoparticl endocyt vesicl adher cell complet detail use execut protocol pleas refer jiang et al	D000072760;D053758	T059;T073
36,317,174	protocol identifi function doppelgng verifi biomed gene express data use doppelgangeridentifi function doppelgng fds independ deriv sampl pair confound machin learn model ml perform assort across train valid set detail use doppelgangeridentifi di provid softwar instal data prepar doppelgng identif function test step demonstr exampl biomed gene express data also provid guidelin select user defin function argument complet detail use execut protocol pleas refer wang et al	D000069550;D012984	T090;T170;T073;T066
36,317,173	protocol modifi surfac nano cu use facet control mof shell coat morpholog nano cu profound determin catalyt perform provid two univers reliabl techniqu modifi surfac nano cu first detail step systemat tune expos facet nano cu rang low index high index use reduct control techniqu presenc sodium dodecyl sulfat second describ step facet direct precipit morpholog depend zif type zeolit imidazol framework shell differ nano cu well introduc complet detail use execut protocol pleas refer luo et al	D017641	T197
36,317,172	protocol chemo regioselect c sp h activ use heterogen copper powder catalyz reaction present protocol synthesi dibenzo c e oxepin h one start alkyl biphenyl carboxyl acid techniqu use two copper catalyz benzyl c sp h activ strategi take either di tertbutyl peroxid gaseous oxygen oxid detail photocatalyt thermal approach copper powder catalyz reaction oxygen also describ procedur catalyst recycl strategi product success synthes mmol gram scale complet detail use execut protocol pleas refer nandi et al	D003300;D016877	T120;T123;T196;T121
36,317,171	two choic assay noxious light avoid tempor distribut analysi drosophila melanogast larva two choic assay allow assess differ behavior includ light avoid drosophila larva typic readout limit prefer index specif end point provid detail protocol set light avoid assay map tempor distribut larva base analysi larval intens describ assay setup implement script analysi easili adapt two choic assay differ model organ complet detail use execut protocol pleas refer imambocus et al	D004331;D004330	T204
36,317,170	protocol induc expand limb bud mesenchym cell human pluripot stem cell present protocol select differenti human pluripot stem cell mimick human development process expand prrx limb bud mesenchym explbm cell approach enabl expans serial passag maintain capac chondrogen differenti complet detail use execut protocol pleas refer yamada et al	D039904;D059630	T025
36,317,140	dlx potenti immun relat prognost indic associ remodel tumor microenviron lung squamous cell carcinoma integr bioinformat analysi still unmet clinic need identifi potent biomark immunotherapi patient lung squamous cell carcinoma lusc	D008175;D002289;D002294	T191
36,317,116	helicobact pylori infect induc intestin dysbiosi could relat onset atherosclerosi cardiovascular diseas repres one first caus death around world atherosclerosi one first step develop although problem occur main elder incid younger peopl report undetermin portion patient without classic risk factor develop subclin atherosclerosi earlier stage life recent h pylori infect intestin microbiota link atherosclerosi mechan behind associ poor understood propos explan effect chronic system inflamm induc h pylori b direct action endotheli cell cytotoxin associ gene protein c alter lipid metabol endotheli dysfunct induc h pylori infect regard microbiota sever studi show induct atherosclerosi relat high level trimethylamin n oxid review present inform publish effect h pylori intestin microbiota relationship atherosclerosi propos hypothesi explain natur associ h pylori contribut atherosclerosi intervent erad restor gut microbiota earli stage could repres way prevent diseas progress	D016481;D016480;D050197	T047;T007;T046
36,317,115	mirna base earli heal mechan extract socket mir p potenti enhanc bone heal tooth extract caus wound hard soft tissu defect alveolar ridg studi report function microrna mirna heal extract socket studi use bioinformat analysi reveal possibl relev role mirna earli stage follow tooth extract	D020390;D035683	T123;T023;T114
36,317,114	remimazolam requir less vasopressor support induct mainten general anesthesia patient sever aortic stenosi undergo transcathet aortic valv replac retrospect analysi singl center compar hemodynam general anesthesia remimazolam convent anesthet patient sever aortic stenosi	D065467;D015742;D018681;D001024	T061;T121;T047;T109
36,317,113	antidiarrh activ dialium guineens willd fruit pulp wistar rat studi aim evalu effect dialium guineens willd fruit pulp powder diarrhea induc castor oil wistar rat	D000930;D007887	T121;T002
36,317,112	identif valid hub gene predict treatment target immun landscap rheumatoid arthriti rheumatoid arthriti ra recogn chronic inflammatori diseas featur patholog synovi inflamm current under pathophysiolog mechan ra remain unclear studi attempt explor under mechan ra provid potenti target therapi ra via bioinformat analysi	D053263;D001172	T047;T044
36,317,111	identif differenti express gene associ prognosi diagnosi hepatocellular carcinoma integr bioinformat analysi goal studi understand possibl core gene associ hepatocellular carcinoma hcc pathogenesi prognosi	D006528;D008113	T191
36,317,110	statin anti inflamm ckd patient meta analysi random trial persist inflamm recogn import comorbid condit patient chronic kidney diseas ckd associ mani complic mortal progress ckd previous studi drawn clear conclus anti inflammatori effect statin ckd meta analysi aim assess anti inflammatori effect statin therapi patient ckd	D019161;D051436	T121;T047;T109
36,317,079	helicobact pylori infect elicit type interferon respons human monocyt via toll like receptor signal helicobact pylori colon persist could preced gastric adenocarcinoma elucid immun recognit strategi h pylori therefor imper curb chronic persist human host toll like receptor tlr tlr wide known viral singl strand rna ssrna sensor yet less studi bacteria context investig involv receptor immun h pylori human thp monocyt cell infect h pylori express level human toll like receptor tlrs examin role tlr tlr respons h pylori infect investig use receptor antagonist among tlr transcript examin tlr exhibit promin upregul follow tlr thp cell infect h pylori j ss strain h pylori infect mediat ifn ifn transactiv signific abrog tlr tlr antagonist addit tlr antagonist treatment reduc h pylori infect mediat phosphoryl interferon regulatori factor irf studi suggest novel role tlr signal host immun h pylori sens live bacteria elicit product type interferon	D016481;D007370;D009000;D051200	T129;T121;T116;T025;T192;T047
36,317,077	multiscal traffic sign detect method complex environ base yolov traffic sign detect challeng problem field unman drive particular import complex environ propos method base improv look yolo v detect recogn multiscal traffic sign complex environ method employ imag preprocess modul classifi denoiz imag complex environ input imag improv yolov also design improv featur pyramid structur replac origin featur pyramid yolov structur use adapt featur fusion modul multiscal featur transfer mechan reduc putat inform loss featur map generat process improv inform transfer deep shallow featur enhanc represent abil featur pyramid final use eiou loss cluster nms improv model perform experiment result fusion tsinghua tencent k collect dataset show propos method achiev map compar exist method method demonstr superior regard traffic sign detect	D000465	T170
36,317,076	fast polynomi time approxim solut knapsack problem knapsack problem kp np hard approxim solut vital solv kp exact paper fast polynomi time approxim solut fptas propos kp fptas local search algorithm best approxim solut kp found neighborhood solut upper bound exact k item knapsack problem e k kp k near critic item fptas practic often achiev high accuraci high speed solv kp comput experi show approxim algorithm kp valid	D000465;D011340	T170;T041
36,317,075	multi level approach segment interstiti lung diseas ild pattern classif base superpixel process fusion k mean cluster spfkmc covid pandem huge interstiti lung diseas ild lung imag captur high time develop effici segment techniqu util separ anatom structur ild pattern diseas infect level identif effect diseas classif direct depend accuraci initi stage like preprocess segment paper propos hybrid segment algorithm design ild imag take advantag superpixel k mean cluster approach segment superpixel imag adapt better irregular local spatial neighborhood help improv perform k mean cluster base ild imag segment overcom limit multiclass belong semiadapt wavelet base fusion appli select k mean cluster perform propos spfkmc compar class fuzzi c mean cluster fcm k mean cluster term accuraci jaccard similar index dice similar coeffici spfkmc algorithm give accuraci dsc jsi propos fuse cluster give better result compar tradit k mean cluster segment wavelet base fuse cluster result	D000086382;D017563	T047;T067
36,317,074	improv efficientnetv model base visual attent mechan applic identif cassava diseas characterist high recognit rate strong network robust convolut neural network becom mainstream method field crop diseas recognit aim problem insuffici number label sampl complex background sampl imag difficult extract use featur inform novel algorithm propos studi base attent mechan convolut neural network cassava leaf recognit specif combin data augment strategi dataset use prevent singl distribut imag dataset pdrnet plant diseas recognit network combin channel attent mechan spatial attent mechan propos algorithm design follow first attent modul embed network layer deploy establish remot depend featur layer strengthen key featur inform suppress interfer featur inform background nois second stochast depth learn strategi formul acceler train infer network final transfer learn method adopt load pretrain weight model propos studi recognit accuraci model enhanc mean detail paramet adjust dynam chang learn rate larg number compar experi demonstr propos algorithm deliv recognit accuraci cassava diseas imag dataset reach state art level among cnn base method term accuraci	D002365	T002
36,317,061	anticanc effect polyphyllin suppress stem cell like properti hepatocellular carcinoma via aktgsk catenin signal pathway polyphyllin ppi also call chong lou saponin steroid saponin isol rhizom pari polyphylla ppi demonstr strong anticanc activ howev effect stem liver cancer stem cell lcscs complet understood herein aim investig effect ppi stem cell like featur lcscs hepatocellular carcinoma hcc lcscs enrich serum free medium treat ppi sorafenib sora ppi sora sever endpoint includ spheroid format differenti cell prolifer surfac marker lcscs ppi bind target stem associ protein express evalu immunofluoresc stain quantit real time polymeras chain reaction sirna transfect coimmunoprecipit ubiquitin assay conduct depth mechanist studi evalu vivo antitumor efficaci demonstr ppi effect inhibit prolifer liver cancer cell self renew differenti lcscs flow cytometri indic ppi suppress express stem cell surfac marker epcam cd molecular dock show high affin ppi protein wnt catenin signal pathway includ akt gsk catenin bind energi kcalmol respect suggest ppi might regul wnt catenin signal pathway affect stem cell like properti hcc ex vivo experi impli ppi activ aktgsk mediat ubiquitin proteasom degrad catenin subsequ attenu prooncogen effect lcscs final anticanc properti ppi confirm vivo found ppi inhibit tumor growth hcc cell line xenograft model taken togeth molecular dock analysi experiment data highlight novel function ppi suppress stem cell like characterist lcscs via aktgsk catenin signal pathway	D006528;D008113;D012503	T191;T109
36,317,060	nfkb gene mutant associ prognosi coronari arteri diseas exacerb endotheli mitochondri fission dysfunct endotheli apoptosi core patholog chang atherosclerot cardiovascular diseas includ coronari arteri diseas cad determin molecular mechan under endotheli apoptosi import nuclear factor kappa b nf b crucial transcript factor control apoptosi previous studi demonstr attg insdel mutant promot nfkb gene rs risk factor cad present studi found nfkb rs polymorph posit associ increas major advers cardiac cerebrovascular event macc cad patient adjust confound factor includ age smoke hypertens glucos low densiti lipoprotein cholesterol mutant dd genotyp independ predictor macc ci p vitro studi show mutant human umbil vein endotheli cell dd mutant huvec suscept high glucosepalmit induc apoptosi accompani decreas p express increas express cleav caspas cytochrom c phospho p p mitochondri membran potenti signific lower increas level mtros open mptp observ dd mutant huvec p furthermor percentag cell fragment spheric mitochondria signific higher dd mutant huvec wild type cell genotyp ii huvec p addit stimul high glucosepalmit nfkb gene mutant signific increas express drp indic nfkb gene mutant affect express mitochondri morpholog relat protein lead excess mitochondri fission conclus mutant dd genotyp nfkb gene independ predictor wors long term prognosi cad patient dd mutant huvec exhibit abnorm activ nf b pathway increas drp express caus excess mitochondri fission dysfunct ultim lead increas apoptosi	D003324	T047
36,316,984	nt afraid eat whole whale use mix method enhanc learn leadership research assess purpos articl identifi proper use mix method leadership research assess articl highlight research assess question best serv mix method offer practition friend guid exampl integr quantit qualit data help eat whole whale one bite time sound decis make design execut present mix method studi outcom assess produc better output great increas likelihood public reput journal b sound program evalu decis c public consumpt studi assess result	D007857;D014907	T078;T015;T054
36,316,983	qualit inquiri leadership develop overview practition scholar articl serv overview qualit inquiri leadership develop practition scholar new experienc begin discuss need qualit inquiri creat knowledg leadership develop overview design compon includ exampl research assess conclud discuss qualiti standard qualit inquiri provid suggest futur direct	D007857	T078;T054
36,316,982	address known unknown student leader develop articl highlight current state know know student leadership develop suggest specif research agenda program assess method articl includ practic descript rigor method could use address issu use exampl research program assess staff descript conceptu model could employ organ leadership program outcom evalu	D007857;D013334	T078;T081;T098;T054
36,316,980	go gold hurdl win strategi conduct longitudin nonlinear research undergradu leader develop articl make case longitudin non linear method research evalu student leadership develop primer longitudin methodolog barrier align solut methodolog challeng present	D007857	T078;T054
36,316,979	assess leadership develop group organ articl discuss consider methodolog leadership educ assess leadership develop group organ use group unit analysi rather aggreg individu score	D007857;D009938	T078;T092;T054
36,316,978	soft tyranni p valu quantit research new consider leadership research articl author discuss process use quantit research render judgment decis result statist analys highlight p valu repres p valu becam ubiquit quantit social scienc research suggest altern way measur signific quantit outcom leadership research also offer	D007857	T078;T054
36,316,977	form follow function research assess design leadership learn articl discuss design research follow question studi seek address articl provid practic divers exampl broad research question applic research program architect summar differ method employ respond	D007857;D007858	T078;T061;T062;T054;T041
36,316,976	assess evalu research balanc ident purpos leadership learn articl explor aspect research assess program evalu qualiti good practic relat share mani similar differ author propos framework consist evalu applic various way studi improv leadership learn local global level	D007857;D007858	T078;T061;T062;T054;T041
36,316,975	room address represent leadership learn research articl explor particip leadership learn initi higher educ repres research assess evalu articl use leadership educ explor conduct leadership research assess evalu scholarship ie posit factor may influenc method find	D007857;D007858	T078;T061;T062;T054;T041
36,316,974	critic transform approach leadership evalu research articl author summar critic transform theori along goal describ approach particular relev within field student leadership develop applic critic transform approach conduct research program evalu effort leadership communiti develop use practic exampl within postsecondari educ also share	D007857	T078;T054
36,316,973	challeng possibl solut adapt virtual recruit lesson learn survey studi covid pandem covid pandem requir rapid chang research protocol includ immedi transit recruit research particip conduct inform consent process virtual case studi detail challeng research team face adapt person behavior intervent survey studi virtual recruit reflect impact rapid chang recruit retent discuss protocol chang made address challeng need potenti enrol particip propos recommend futur work use comput technolog display profession return phone number flexibl contact potenti particip various mean minim email communic due ad regulatori requir partner institut review board shorten improv consent document process critic studi success case studi offer insight research navig similar process virtual recruit like continu import ensur facilit rather hinder equit recruit practic	D000086382	T047;T067
36,316,972	particip perspect payment research particip qualit studi investig common offer payment research particip promot recruit retent yet ethic offer monetari incent research particip continu debat prior conceptu work address concern howev also need empir evid understand effect payment particip report result qualit studi compris discours analysi recruit convers studi coordin potenti particip actual clinic trial semistructur interview particip address effect incent decis make mani particip report money motiv enrol clinic trial use reason suggest undu influenc unjust induc find add grow bodi literatur suggest payment ethic accept tool promot recruit retent clinic trial	D009042;D035842	T078;T098;T041;T080
36,316,971	demonstr project transit research network new singl irb platform sinc nation institut health nih mandat use singl irb sirb multicent research institut struggl operation process demonstr project univers utah trial innov center assist collabor pediatr critic care research network transit use individu negoti relianc agreement paper base document new sirb master agreement informat platform captur relianc document lesson learn guid academ institut irb operation sirb includ need site understand type engag relianc requir need understand differ relianc activ requir around local review remain poor understood research need determin approach achiev nih vision review becom effici improv studi start time reliev administr burden advanc human research protect	D028744;D009316	T093;T097
36,316,970	ethic framework disclosur alzheim diseas biomark research particip conflict norm nuanc polici frequent clinic trial alzheim diseas ad target cognit unimpair individu increas risk develop diseas alway clear whether ad biomark inform disclos research particip one hand research particip may interest learn inform perceiv util hand learn inform may harm effect prevent therapeut option avail ad articl bring togeth three separ set ethic guidanc literatur return individu research result individu right access person data transpar enrol clinic trial base literatur suggest polici disclosur ad biomark test result longitudin observ cohort studi clinic trial hybrid research project european prevent alzheim dementia epad project serv ethic team also present critic discuss recommend disclosur ad biomark practic underscor long clinic valid ad biomark remain limit good reason avoid activ disclos cognit unimpair research particip	D000544	T047;T048
36,316,965	questionnair base studi patient poland evalu cours inflammatori bowel diseas effect covid pandem qualiti life mental state februari june background covid pandem affect mani peopl worldwid includ chronic diseas object analyz influenc medic care cours inflammatori bowel diseas ibd poland materi method patient poland ibd complet origin anonym questionnair impact covid pandem cours diseas mental status print questionnair distribut ibd patient treat gastroenterolog outpati clinic univers clinic hospit biaystok onlin questionnair sent patient via social media statist analysi perform use chi squar test signific level p result studi group consist women men mean age year fifti nine patient ulcer coliti crohn diseas patient report signific deterior medic avail restrict access gastroenterolog outpati clinic p patient contract covid requir hospit asymptomat mild moder despit immunosuppress biolog treatment steroid respond state pandem negat affect mental state associ worsen ibd conclus pandem respond main concern difficulti access gastroenterolog clinic limit drug avail pandem negat affect patient mental state case covid diseas patient ibd most asymptomat requir hospit despit therapi affect immun system	D000086382;D015212	T047;T067
36,316,964	central retin vein occlus discontinu rivaroxaban therapi young patient covid pulmonari embol case report background present report first case best knowledg central retin vein occlus crvo occur day anticoagul discontinu patient histori pulmonari embol cours covid case report previous healthi year old man hospit april sever covid pneumonia complic segment subsegment pulmonari embol patient treat concurr combin remdesivir dexamethason therapeut enoxaparin ceftriaxon passiv oxygen therapi convalesc plasma therapi led pulmonari improv treatment therapeut enoxaparin mg ml twice day continu month discharg follow mg rivaroxaban twice day week mg rivaroxaban day week within day rivaroxaban discontinu patient experienc decreas visual acuiti right eye level nonischem crvo cystoid macular edema diagnos intravitr inject ranibizumab perform common identifi factor contribut crvo exclud treatment prophylact enoxaparin initi two week later macular edema decreas signific visual acuiti improv treatment enoxaparin discontinu conclus rebound hypercoagul discontinu rivaroxaban therapi manifest crvo young patient histori covid pulmonari embol success treat intravitr inject ranibizumab	D012170;D000086382;D008269;D011655	T047;T046;T067
36,316,951	effect novel techniqu sensit skin treatment optim puls technolog clinic studi photomodul non phototherm effect mobil energi regul cell activ mitochondri level use treat sensit skin ss recent year base photomodul effect optim puls technolog opt develop novel treatment mode advanc opt low energi three puls long puls width aopt ltl treatment facial ss evalu effect	D015595	T033;T042
36,316,948	dissemin cryptococcosi mimick malign lymphoma f fdg petct case report dissemin cryptococcosi extrem rare easili misdiagnos malign lymphoma f fluorodeoxyglucos positron emiss tomographi pet comput tomographi ct may use assess involv dissemin cryptococcosi evalu residu diseas treatment	D008223;D003453	T047;T191
36,316,947	prospect analysi concentr ohd northern southern district japan year round studi although osteoporot patient alreadi recogn low volum vitamin status concentr activ vitamin precursor studi detail trial aim clarifi concentr hydroxyvitamin ohd natur type vitamin compar separ area japan compar clarifi concentr ohd separ area japanes patient diagnos osteoporosi base bone miner densiti studi analyz differ hospit patient whose resid separ northern district akita citi north latitud southern district shizuoka citi north latitud complet differ daylight hour three hundr sixti eight patient akita shizuoka enrol trial compar differ concentr ohd welch test signific differ concentr ohd age akita patient signific higher shizuoka patient despit shizuoka much daylight hour akita conclus might relationship concentr ohd exposur sunlight	D010024;D014808	T047
36,316,946	immedi postop lumbar spine magnet reson imag correl postop pain lumbar microdiscectomi magnet reson imag mri extens use manag patient herniat lumbar disc nevertheless immedi postop mri becom standard procedur limit research suggest find often similar preoper mri symptomat asymptomat patient studi aim determin benefit immedi postop mri patient without postop symptom correl symptom total patient underw lumbar spine microdiscectomi institut includ patient previous spinal surgeri lumbar fusion exclud patient data collect medic record mri perform day surgeri assess neurosurgeon minim bias immedi postop mri result show dural sac compress foramin stenosi patient postop pain pain free among patient without find mr imag postop pain immedi postop mri correl postop pain p intraop bleed charlson comorbid index cci show signific correl postop pain p respect multivari analysi intraop blood loss cci independ correl postop pain p respect base find intraop blood loss cci appear factor may predict persist postop pain despit normal find mri	D016063;D008159	T023;T046
36,316,945	impair rate depend depress h reflex type diabet prediabet overweight obes cross section studi type diabet chronic metabol disord character hyperglycemia result deficit insulin secret insulin resist accord intern diabet feder approxim million peopl suffer condit rapid increas impact low middl incom countri obes well known risk factor diabet current data project continu increas diabet preval worldwid obes individu among common complic diabet peripher neuropathi dpn caus sensori symptom includ pain contribut foot ulcer control limb amput may occur diagnosi dpn clinic problem rate depend depress rdd hoffmann reflex lower limb propos test determin presenc neuropath pain subject type type diabet recent impair rdd describ obes diabet rodent model studi character rdd evalu h reflex hz patient type diabet mellitus tdm control without diabet subsequ classifi overweightobes prediabet signific decreas rdd h reflex found tdm subject hz p stimul frequenc compar control hz p major find studi impair rdd also found overweight obes subject least stimul frequenc classifi prediabet level accord hbac valu rdd h reflex could use quantit sensit tool studi tdm subpopul peripher neuropathi rdd could use screen tool combin clinic test diagnos dpn evalu progress condit	D011236;D003924;D003929;D009437	T184;T047
36,316,944	influenc geometr algebra surgic practic sleev gastrectomi singl center experi laparoscop surgeri could consid art geometr algebra howev littl studi context bariatr surgeri current studi aim explor possibl influenc concept geometr algebra surgic process overweight obes patient set laparoscop sleev gastrectomi lsg studi period clinic data subject underw lsg retrospect analyz paramet examin includ bodi mass index bmi umbil xiphoid interv u x umbil fundus u f interv studi lsg perform via central view approach c left view approach l group bodi surfac project point view hole v main accessori oper hole surfac display fundus f connect form geometr figur access surgic instrument fundus need elong instrument relat intra post oper paramet note overweight obes subject show signific increas u x u f interv compar non obes subject length u x u f interv correl bmi geometr figur quit differ l c approach signific increas area quadrangl signific longer f f v f interv calcul c approach patient thus elong instrument frequent requir integr concept geometr algebra proper select troca may provid better surgic experi smooth surgic process	D009767;D050110;D010535	T061;T060;T047
36,316,943	mind tributari canal stent necessari insulinoma enucl proxim promin duct santorini case report literatur review describ case insulinoma locat extrem close accessori pancreat duct apd away main pancreat duct mpd previous studi show insulinoma enucl safe procedur small benign tumor mm distant mpd howev case enucl tumor led unanticip apd injuri grade b post oper pancreat fistula popf provid detail record clinic manag argu enucl tumor near apd need care weigh	D007340;D010190	T191
36,316,942	decis curv analysi identifi optim candid liver resect intermedi stage hepatocellular carcinoma hepat b cirrhosi cohort studi select criterion liver resect lr intermedi stage im hepatocellular carcinoma hcc still controversi studi aim compar lr transarteri chemoembol tace rang predict death risk multivari cox regress model mvr estim predict mortal year cutoff valu determin piec wise linear regress model decis curv analysi mvr model hazard ratio curv treatment plot predict mortal im hepatocellular carcinoma im hcc hepat b cirrhosi includ analysi tace n lr n year overal surviv os rate lr patient higher tace group vs p ci predict death risk decis curv analysi suggest lr tace increas net benefit patient divid subgroup cutoff valu stratifi analysi treatment differ subgroup hazard ratio ci ci ci ci respect lr reach maxim relat util interv lr tace increas net benefit year death risk	D006528;D016461;D008113;D006509	T061;T047;T191
36,316,941	role sarcopenia treatment relat outcom patient renal cell carcinoma systemat review meta analysi recent year attent paid fuzzi relationship skelet muscl compon renal cell carcinoma rcc studi attempt conduct meta analysi use relev research evid explor impact sarcopenia final surviv recurr outcom rcc patient chang process impact treatment	D002292;D055948;D007680	T047;T191
36,316,940	unprep hiv prevent servic hesit among us primari care provid provis hiv prevent servic primari care pcp healthcar provid critic reduc number new hiv infect examin perform hiv risk assess provis hiv prevent servic pcps cohort less one half respond ask sex drug use time among routin ask sex drug use respect would ask given time less quarter respond note hiv prevent servic part clinic practic find demonstr gap provis hiv prevent servic key popul healthcar provid	D015658;D000163	T047
36,316,939	effect tradit chines medicin base rehabilit nurs combin scalp acupunctur negat emot qualiti life patient stroke random control trial studi aim analyz effect tradit chines medicin base rehabilit nurs combin scalp acupunctur tcmrn sa negat emot qualiti life patient stroke	D019145;D015670;D020521	T061;T047;T091
36,316,938	effect glp receptor agonist asprosin level normal weight overweightobes patient type diabet mellitus asprosin newli identifi adipokin glucos rais appetit enhanc effect act differ known hepat glucos util pathway studi investig chang serum asprosin level normal weight overweightobes liraglutid treat patient type diabet tdm studi non random prospect observ studi metabol paramet asprosin level compar peopl tdm peopl normal glucos toler ngt treatment phase tdm patient given liraglutid dose mgd first week mgd subsequ week mgd follow week tdm patient separ normal weight group overweightobes group compar chang asprosin paramet pre post treatment tdm group signific higher fast asprosin h postprandi asprosin level ngt group p fast asprosin postprandi asprosin posit correl bmi hpg hbac tg homa ir negat correl hdl c tdm ngt group asprosin level decreas liraglutid treatment normal overweightobes tdm group p signific reduc bodi weight bmi overweightobes tdm patient p fast postprandi serum asprosin concentr higher tdm patient compar normal glucos control fast postprandi asprosin posit correl bmi hpg hbac tg homa ir negat correl hdl c particip liraglutid lower asprosin level tdm patient reduc weight bmi overweight obes type diabet	D003924;D000067757;D007333;D000071838	T123;T116;T192;T047;T046
36,316,937	risk factor dexmedetomidin associ bradycardia spinal anesthesia retrospect studi sedat dexmedetomidin need patient undergo spinal anesthesia howev dexmedetomidin sedat increas incid bradycardia aim identifi evalu risk factor bradycardia patient undergo spinal anesthesia dexmedetomidin sedat record patient underw spinal anesthesia sedat use dexmedetomidin review retrospect studi identifi characterist includ patient group underw lower leg surgeri estim blood loss ml collect detail potenti risk factor bradycardia clinic record factor includ age american societi anesthesiologist classif height weight sensori level spinal anesthesia histori hypertens diabet mellitus load mainten dose dexmedetomidin tourniquet time initi diastol systol blood pressur initi heart rate hr anesthesia surgeri durat primari endpoint studi occurr bradycardia identifi potenti risk factor use logist regress analysi incid bradycardia obtain patient initi hr tourniquet time signific individu predict factor occurr bradycardia logist regress analysi show adjust baselin hr durat tourniquet use risk factor bradycardia patient monitor undergo spinal anesthesia sedat use dexmedetomidin bradycardia long tourniquet time low initi hr could also predict factor bradycardia	D000775;D020927	T061;T121;T109
36,316,936	delay diagnosi manag necrot fasciiti left lower leg case report necrot fasciiti nf rare sever soft tissu infect character rapid extens necrosi skin subcutan tissu superfici deep fascia frequent misdiagnos infecti diseas lead inappropri treatment potenti serious consequ may complic septic shock multipl organ failur fatal outcom	D019115;D012772	T047;T046
36,316,935	prognost nutrit index outcom predictor patient iliopsoa abscess case iliopsoa abscess ipa singl hospit base case review compar clinic profil publish hospit base ipa seri verifi use prognost nutrit index pni use predict outcom sever ipa studi perform studi consist part studi case review ipa seri singl hospit case ipa treat singl hospit sequenti year collect seri clinic profil compar studi review hospit base literatur search pubm databas present perform use boolean express psoa iliopsoa abscess hospit base two hospit base case seri collect clinic profil seri compar seri draw predict factor outcom decid treatment modal medic surgic studi analyz ipa case averag age year old vari lifesav rate pni calcul serum albumin alb total lymphocyt count larger cumul abscess volum cav measur comput tomographi seem outcom predictor studi analyz hospit base ipa seri seri seri review isol ipa case without comorbid seri review ipa case cardiovascular disord among seri includ seri show oldest case longer length hospit seri show highest mortal among collect ipa cardiovascular comorbid pni seem predictor outcom diseas activ patient ipa might indic treat surgic intervent	D016659	T047

36,317,351

type cervic disc herniat mri correl clinic outcom aim studi investig whether type cervic disc herniat influenc sever symptom time present outcom surgic treatment

D007405;D011843;D013123;D055959

T061;T047;T190;T037

36,317,350

combin high preoper pain low radiolog grade arthriti associ greater intens persist pain month total knee arthroplasti despit new technolog total knee arthroplasti tka approxim patient dissatisfi major reason dissatisfact revis surgeri tka persist pain radiolog grade osteoarthr oa preoper investig predictor outcom tka conflict result aim studi determin differ intens pain month tka relat preoper radiolog grade oa alon combin intens preoper pain radiolog grade oa

D019645;D020370

T061;T047

36,317,349

platelet rich plasma inject acut achill tendon ruptur two year follow path random placebo control superior trial determin whether platelet rich plasma prp inject improv outcom two year acut achill tendon ruptur

D000125;D013708;D053657;D016512

T023;T037;T031

36,317,348

distal tibial osteotomi compar proxim osteotomi limb lengthen children aim retrospect cohort studi assess investig safeti efficaci use distal tibial osteotomi compar proxim osteotomi limb lengthen children

D001852

T061

36,317,347

periprosthet joint infect next periprosthet joint infect pji remain extrem challeng complic focus issu last decad previous still mani unansw question workabl definit everyon align need continu focus identifi organ involv surgic strategi evolv care becom patient centr good studi way howev still numer problem resolv challeng pji remain major one orthopaed communiti annot provid date thought way forward still scope plenti research areacit articl bone joint j b

D016459;D019644;D019645;D001170

T061;T047;T046

36,317,346

arthroscop bicep augment improv clinic outcom incomplet repair larg massiv rotat cuff tear studi compar patient underw arthroscop repair larg massiv rotat cuff tear lmrcts isol incomplet repair tear patient incomplet repair bicep tendon augment aim evalu addit benefit clinic outcom capac lower tear rate

D000070636

T033;T047;T037

36,317,345

assess influenc modifi patient relat factor complic rate adult spinal deform surgeri postop complic rate remain relat high adult spinal deform asd surgeri extent modifi patient relat factor influenc complic rate patient asd effect evalu aim retrospect cohort studi evalu associ modifi patient relat factor complic correct surgeri asd

D013123;D010024

T061;T047

36,317,343

spinal versus general anaesthesia contemporari primari total knee arthroplasti spinal anaesthesia seen increas use contemporari primari total knee arthroplasti tkas howev controversi exist benefit spinal comparison general anaesthesia primari tkas studi aim investig pain control length stay los complic associ spinal versus general anaesthesia primari tkas singl high volum academ centr

D007720;D019645

T061;T074

36,317,342

cost util analysi surgic fixat kirschner wire versus cast fractur distal radius health econom evalu drafft trial aim studi compar cost effect surgic fixat kirschner k wire ersus mould cast manipul fractur distal radius oper theatr set

D050723;D011885

T037

36,317,327

editori recent approv sotorasib first target therapi kras gc mutat advanc non small cell lung cancer nsclc past two decad rapid advanc number rang regulatori approv target therapi patient advanc non small cell lung cancer nsclc cancer kirsten rat sarcoma viral oncogen homolog kras gene high mutat rate human cancer associ aggress type cancer includ nsclc pancreat ductal adenocarcinoma pdac colorect cancer crc recent sever common high aggress cancer kras mutat express death star kras protein consid undrugg amen target therapi main kras mutat singl base missens mutat occur codon gc kras gc common kras mutat nsclc sotorasib first class specif small molecul irrevers inhibit kras gc base result phase codebreak safeti toler studi may us food drug administr fda grant acceler approv sotorasib adult advanc nsclc kras gc mutat editori aim present current status regulatori approv support clinic trial data sotorasib first target therapi patient advanc nsclc kras gc mutat

D000970;D002289;D008175

T121;T191;T109

36,317,291

develop core outcom set hospit deprescrib trial older peopl care geriatrician half older peopl prescrib unnecessaryinappropri medic routin deprescrib hospit henc need deprescrib trial aim develop core outcom set cos deprescrib trial older peopl care geriatrician hospit admiss

D000072219;D000069340

T058;T170;T097

36,317,259

transgen schwann cell overexpress pouf promot sciatic nerv regener within acellular nerv allograft object acellular nerv allograft ana effect surgic approach use bridg sciatic nerv gap molecular regul post surgic recoveri well known explor effect transgen schwann cell scs overexpress pou domain class transcript factor pouf sciatic nerv regener within ana explor function pouf nerv regener use cell model h induc scs injuri transplant scs overexpress pouf ana repair sciatic nerv gap approach use rna seq protein protein interact network analysi gene ontolog enrich kyoto encyclopedia gene genom pathway analysi identifi high differenti express transcript factor pouf follow ana treatment sciatic nerv gap express high degre connect pouf predict play role peripher nervous system myelin main result test role pouf nerv regener ana infect scs adeno associ virus pouf demonstr pouf overexpress promot prolifer anti apoptosi migrat scs vitro also found pouf signific upregul jnk c jun phosphoryl select jnk inhibit attenu effect pouf prolifer surviv migrat jnk c jun phosphoryl direct interact pouf activ jnk subsequ confirm co immunoprecipit rat sciatic nerv injuri model mm gap confirm pattern pouf upregul co local transplant scs ana load pouf overexpress scs demonstr enhanc surviv transplant scs axon regener myelin function motor recoveri compar ana group load scs line vitro find signific studi identifi pouf novel regul post injuri sciatic nerv repair act jnkc jun signal scs optim therapeut outcom ana surgic approach

D020426;D059348

T047;T037

36,317,255

decod lexic tone vowel imagin tonal monosyl use fnir signal object speech common way communic decod verbal intent could provid naturalist communic way peopl sever motor disabl activ brain comput interact bci speller one common use speech bcis reduc spell time chines word identifi vowel tone embed imagin chines word essenti function near infrar spectroscopi fnir wide use bci portabl non invas safe low cost relat high spatial resolut approach studi activ bci speller base fnir present covert rehears tonal monosyl vowel ie u four lexic tone mandarin chines ie tone main result fnir result show signific differ right superior tempor gyrus imagin vowel tone tone ie activ stronger connect brain region imagin vowel tone tone speech relat area tone imageri ie right hemispher provid major inform identifi tone left hemispher advantag vowel identif decod vowel tone post stimulus period averag classif accuraci exceed multiclass ie four class binari set respect spell word quick time window size decod reduc classif accuraci signific reduc signific first time work demonstr possibl discrimin lexic tone vowel imagin tonal syllabl simultan addit reduc time window decod indic spell time chines word could signific reduc fnir base bcis

D013060;D013067

T041;T040;T054

36,317,248

feasibl cd base portabl xrf devic measur skin iron concentr anaem thalassaem patient iron essenti element vital growth develop sever effect bodi due iron defici overload prompt sustain research accur vivo iron measur techniqu past sever decad x ray fluoresc xrf analysi iron bodi investig work non invas natur techniqu system design use silicon drift detector measur low energi iron k x ray excit sampl silver x ray cd energi kev kev sourc contain within tantalum shield cap design reduc spectral background system calibr print polylact acid pla phantom fill solut iron various concentr iron x ray signal normal nickel x ray signal improv system reproduc phantom normalis result linear calibr line p real time measur minimum detect limit system measur ppm achiev low radiat dose msv skin surfac low detect limit low dose mean system feasibl applic human measur iron defici overload diseas system proceed post mortem valid studi prior vivo system efficaci test

D007501;D002104

T123;T196;T121;T131

36,317,246

segment geometri left coronari arteri coronari ct angiographi use deep learn hemodynam evalu coronari ct angiographi ccta crucial detect sever coronari arteri diseas fail provid essenti hemodynam paramet earli detect treatment paramet easili obtain perform comput fluid dynam cfd analysi arteri geometri generat ccta imag segment coronari arteri small size manual segment left coronari arteri ccta scan labori time intens error prone complic task also requir high level expertis academ recent propos various autom segment techniqu combat issu aid process present coronarysegnet deep learn base framework autonom accur segment well generat geometri left coronari arteri design base origin u net topolog includ channel awar attent block well deep residu block spatial dropout contribut featur map independ elimin featur map rather individu compon train test statist evalu model use ccta imag acquir various medic center across bangladesh rotterdam coronari arteri algorithm evalu challeng dataset improv general empir assess coronarysegnet outperform sever cut edg segment algorithm attain dice similar coeffici averag high signific p addit geometri generat machin learn semi automat method statist similar moreov hemodynam evalu perform geometri show compar result

D000072226;D000077321

T060;T066

36,317,231

fuzzi infer system fis long short term memori lstm network electromyographi emg signal analysi wide rang applic domain remot robot control rehabilit remot surgeri requir captur neuromuscular activ reliabl applic high depend abil decod intent accur base captur neuromuscular signal physiolog signal electromyographi emg electroencephalographi eeg generat neuromuscular activ contain intrins pattern user particular action action general classifi motor state forward revers hand grip hand releas classifi motor state truth signal must captur decod correct paper propos novel classif techniqu use fuzzi infer system fis long short term memori lstm network classifi motor state base emg signal exist emg signal classif techniqu general reli featur deriv data captur specif time instanc typic approach consid tempor correl signal entir window paper propos lstm fuzzi logic method classifi four major hand movement forward revers rais lower featur associ pattern generat throughout motor state movement extract explor publish data within given time window classif result achiev accuraci way action forwardreversegripupreldown forwardrevers action gripupreldown action way action propos mechan demonstr high level human interpret result employ rehabilit medic devic industri

D008570;D017143

T170;T041

36,317,229

characterist barrier facilit initi develop interprofession collabor rural remot primari healthcar facil scope review despit strong evid support interprofession collabor ipc document need collabor practic primari health care phc initi promot ipc rural remot phc facil extens studi purpos articl map interprofession educ ipe interprofession practic ipp initi implement promot ipc rural remot phc facil identifi barrier facilit implement

D007400;D003299

T054

36,317,226

associ air pollut csf strem cognit normal older adult cabl studi ambient air pollut aggrav process alzheim diseas ad patholog current exact inflammatori mechan under link clinic research remain larg unclear

D000544;D000397

T047;T080;T069;T048

36,317,221

para bombay phenotyp due bi allel heterozyg base delet fut gene explor genet mechan under case para bombay phenotyp

D000017;D005647

T185;T129;T116;T109;T126

36,317,220

associ gstp plce gene polymorph primari esophag cancer assess associ polymorph glutathion transferas p gstp phospholipas c epsilon plce gene suscept primari esophag cancer interact environment factor

D020022;D004938

T032;T191

36,317,219

associ genom instabl cdh gene clinicopatholog characterist gastric cancer assess associ genom instabl epitheli cadherin cdh gene clinicopatholog characterist gastric cancer

D013274

T191

36,317,218

analysi patient kallmann syndrom x xy karyotyp explor etiolog patient kallmann syndrom congenit hypogonad anosmia x xy karyotyp

D007006;D017436

T047

36,317,217

analysi clinic featur ebf gene variant child hypotonia ataxia development delay explor genet basi child featur hypotonia ataxia delay develop syndrom hadd

D008607;D009123

T033;T184;T047;T048

36,317,216

genet diagnosi child caf au lait macul juvenil xanthogranuloma explor genet basi child caf au lait macul juvenil xanthogranuloma

D009456;D014972

T047;T191

36,317,215

analysi novel compound heterozyg variant gja gene child congenit cataract explor genet basi child congenit cataract

D002386

T033;T047;T190

36,317,214

identif novel variant chines patient chediak higashi syndrom explor genet basi child featur chediak higashi syndrom chs

D002609

T047

36,317,213

analysi clinic featur genet variant chines pedigre affect famili adenomat polyposi analyz clinic featur genet basi chines pedigre affect famili adenomat polyposi fap

D025601;D011125

T123;T047;T191;T116

36,317,212

analysi clinic phenotyp genet variant chines pedigre affect cleidocrani dysplasia analyz clinic featur pathogen variant chines pedigre affect cleidocrani dysplasia ccd

D002973

T047

36,317,211

analysi hprt gene variant prenat diagnosi chines pedigre lesch nyhan syndrom specimen affect proband carri genet test prenat diagnosi chines pedigre lesch nyhan syndrom lns specimen affect proband

D007926

T047

36,317,210

clinic characterist genet analysi chines pedigre affect tuber sclerosi complex explor genet basi chines pedigre affect tuber sclerosi complex tsc

D014402

T191

36,317,209

analysi proc gene variant chines pedigre affect hereditari protein c defici explor molecular pathogenesi chines pedigre affect inherit protein c pc defici

D020151

T047

36,317,208

genet analysi prenat diagnosi chines pedigre affect bainbridg roper syndrom explor clinic featur genet basi child bainbridg roper syndrom brps

D002658;D008607

T048

36,317,207

analysi two chines pedigre affect alport syndrom due novel variant cola gene explor genet basi two chines pedigre affect alport syndrom

D009394

T047

36,317,206

multiplex pcr base sensit specif method detect chromosom materi patient turner syndrom develop multiplex pcr method rapid detect chromosom specif sequenc patient turner syndrom

D014424

T047

36,317,205

clinic signific serum mirna ox ldl ros express patient primari ovarian insuffici investig clinic signific mirna ox ldl ros patient primari ovarian insuffici poi

D035683;D016649

T123;T047;T114

36,317,204

analysi clinic featur genet variant three chines pedigre affect limb girdl muscular dystrophi type analyz clinic featur genet variant three chines pedigre affect limb girdl muscular dystrophi type lgmdi

D010430;D049288

T047;T126;T116

36,317,203

prenat diagnosi partial delet nrxn gene combin cnv seq qpcr assay summar genet diagnosi low depth copi number variat sequenc cnv seq prenat find fetus p delet involv nrxn gene

D015816;D056915

T045;T123;T116;T086

36,317,202

applic valu high throughput sequenc detect thalassemia ethnic li minor area assess valu high throughput sequenc detect thalassemia associ variant ethnic li minor area hainan china

D017085;D017086

T047

36,317,201

clinic evalu true fals posit z valu among high risk case screen non invas prenat test analyz z valu true fals posit case non invas prenat test nipt order improv accuraci clinic practic

D004314;D025063

T019;T047

36,317,200

clinic practic guidelin fragil x syndrom fragil x syndrom fxs common monogen form inherit intellectu disabl autism spectrum disord asd individu fxs caus unstabl expans cgg repeat locat within untransl region fmr gene clinic featur fxs includ various degre cognit deficit physic behavior psychiatr problem earli treatment prevent affect children guid molecular genet test fmr gene follow guidelin combin relev research guidelin consensus worldwid summar genet knowledg clinic treatment fxs order achiev standard diagnosi treatment prevent patient famili affect diseas

D000067877;D005600;D008607

T047;T048

36,317,185

cost effect singl versus multipl inhal tripl therapi uk copd popul intrepid trial week intrepid trial demonstr clinic benefit daili singl inhal tripl therapi sitt fluticason furoat umeclidinium vilanterol ffumecvi versus non ellipta multipl inhal tripl therapi mitt patient symptomat chronic obstruct pulmonari diseas copd analysi assess cost effect ffumecvi versus non ellipta mitt treatment symptomat copd unit kingdom uk nation health servic nhs perspect

D009330;D029424

T047;T074

36,317,184

effect hospit pharmacist intervent copd patient systemat literatur review logic model review aim summar empir evid pharmacist led intervent chronic obstruct pulmonari diseas copd patient hospit set identifi compon logic model includ input intervent output outcom contextu factor inform develop hospit pharmacist role copd manag

D010595;D029424

T047;T097

36,317,181

protocol high throughput screen sar cov main proteas inhibitor use robust fluoresc polar assay discoveri efficaci antivir agent target sar cov main proteas mpro highest import fight covid describ simpl protocol high throughput screen mpro inhibitor use robust fluoresc polar fp assay candid mpro inhibitor larg compound librari could rapid identifi monitor chang millipolar unit valu afford fp assay modifi screen antivir agent target virus proteas complet detail use execut protocol pleas refer li et al yan et al yan et al c

D057166;D000086382

T047;T059;T067

36,317,180

crispr cas induc gene knockout zebrafish applic crispr great facilit genotyp phenotyp studi human diseas model protocol describ crispr cas induc gene knockout zebrafish util purifi cas protein vitro transcrib sgrna protocol target phlpp gene indian wild caught strain broad applic major factor influenc protocol success includ zebrafish health fecund sgrna effici specif germlin transmiss mutant viabil complet detail use execut protocol pleas refer balamurugan et al

D015027;D064113

T040;T013

36,317,179

clone brd long isoform overexpress vector stabl overexpress brd l mammalian cell molecular clone brd l challeng techniqu dna insert form long gc rich sequenc fold secondari structur present protocol defin specif strategi amplifi brd l follow success clone gene overexpress vector sinc exist protocol commerci avail plasmid work provid use tool studi involv molecular clone brd l could potenti appli challeng gene

D005822;D009687

T123;T116;T114

36,317,178

protocol generat patient deriv xenograft model acquir resist immunotherapi human mice immunotherapi revolution cancer treatment preclin model requir understand immunotherapi resist mechan under patient relaps protocol describ generat acquir resist human vivo model immunotherapi patient deriv xenograft pdx detail step inject human cd cell nsg mice follow generat immunoresist pdx human mice approach recapitul human immun system allow investig generat preclin resist model differ immunotherapi identifi resist phenotyp complet detail use execut protocol pleas refer martnez sabadel et al arena et al

D007167

T061

36,317,177

high content live cell multiplex screen chemogenom compound annot base nuclear morpholog well character small molecul enabl studi cell process facilit target valid describ high content multiplex screen investig cell viabil h combin investig phenotyp featur tubulin bind mitochondri content initi cellular qualiti control divers compound protocol live cell basi easili adapt scalabl detail cell prepar compound handl plate layout configur imag acquisit cq data analysi use cellpathfind softwar complet detail use execut protocol pleas refer tjaden et al

D012984;D008928

T026;T090;T073;T170;T043

36,317,176

protocol atmospher water harvest use situ polymer honeycomb hygroscop polym atmospher water harvest awh offer solut effici extract water air protocol detail step develop composit sorbent load hygroscop salt lithium chlorid licl base hydrogel acrylamid monom carbon nanotub cnts describ streamlin experiment approach synthesi honeycomb optim hydrogel base composit adsorb pclg situ polymer produc sorbent exhibit ultra high adsorptiondesorpt capac per unit volum low temperatur desorpt complet detail use execut protocol pleas refer wang et al

D011108;D037742

T104;T122;T073

36,317,175

quantifi transport dynam three dimension singl particl track adher cell intracellular transport play import role maintain physiolog function cell describ protocol singl particl track within live cell detail use two focal imag system analyt step quantifi transport dynam protocol use character intracellular diffus traffick macromolecul nanoparticl endocyt vesicl adher cell complet detail use execut protocol pleas refer jiang et al

D000072760;D053758

T059;T073

36,317,174

protocol identifi function doppelgng verifi biomed gene express data use doppelgangeridentifi function doppelgng fds independ deriv sampl pair confound machin learn model ml perform assort across train valid set detail use doppelgangeridentifi di provid softwar instal data prepar doppelgng identif function test step demonstr exampl biomed gene express data also provid guidelin select user defin function argument complet detail use execut protocol pleas refer wang et al

D000069550;D012984

T090;T170;T073;T066

36,317,173

protocol modifi surfac nano cu use facet control mof shell coat morpholog nano cu profound determin catalyt perform provid two univers reliabl techniqu modifi surfac nano cu first detail step systemat tune expos facet nano cu rang low index high index use reduct control techniqu presenc sodium dodecyl sulfat second describ step facet direct precipit morpholog depend zif type zeolit imidazol framework shell differ nano cu well introduc complet detail use execut protocol pleas refer luo et al

D017641

T197

36,317,172

protocol chemo regioselect c sp h activ use heterogen copper powder catalyz reaction present protocol synthesi dibenzo c e oxepin h one start alkyl biphenyl carboxyl acid techniqu use two copper catalyz benzyl c sp h activ strategi take either di tertbutyl peroxid gaseous oxygen oxid detail photocatalyt thermal approach copper powder catalyz reaction oxygen also describ procedur catalyst recycl strategi product success synthes mmol gram scale complet detail use execut protocol pleas refer nandi et al

D003300;D016877

T120;T123;T196;T121

36,317,171

two choic assay noxious light avoid tempor distribut analysi drosophila melanogast larva two choic assay allow assess differ behavior includ light avoid drosophila larva typic readout limit prefer index specif end point provid detail protocol set light avoid assay map tempor distribut larva base analysi larval intens describ assay setup implement script analysi easili adapt two choic assay differ model organ complet detail use execut protocol pleas refer imambocus et al

D004331;D004330

T204

36,317,170

protocol induc expand limb bud mesenchym cell human pluripot stem cell present protocol select differenti human pluripot stem cell mimick human development process expand prrx limb bud mesenchym explbm cell approach enabl expans serial passag maintain capac chondrogen differenti complet detail use execut protocol pleas refer yamada et al

D039904;D059630

T025

36,317,140

dlx potenti immun relat prognost indic associ remodel tumor microenviron lung squamous cell carcinoma integr bioinformat analysi still unmet clinic need identifi potent biomark immunotherapi patient lung squamous cell carcinoma lusc

D008175;D002289;D002294

T191

36,317,116

helicobact pylori infect induc intestin dysbiosi could relat onset atherosclerosi cardiovascular diseas repres one first caus death around world atherosclerosi one first step develop although problem occur main elder incid younger peopl report undetermin portion patient without classic risk factor develop subclin atherosclerosi earlier stage life recent h pylori infect intestin microbiota link atherosclerosi mechan behind associ poor understood propos explan effect chronic system inflamm induc h pylori b direct action endotheli cell cytotoxin associ gene protein c alter lipid metabol endotheli dysfunct induc h pylori infect regard microbiota sever studi show induct atherosclerosi relat high level trimethylamin n oxid review present inform publish effect h pylori intestin microbiota relationship atherosclerosi propos hypothesi explain natur associ h pylori contribut atherosclerosi intervent erad restor gut microbiota earli stage could repres way prevent diseas progress

D016481;D016480;D050197

T047;T007;T046

36,317,115

mirna base earli heal mechan extract socket mir p potenti enhanc bone heal tooth extract caus wound hard soft tissu defect alveolar ridg studi report function microrna mirna heal extract socket studi use bioinformat analysi reveal possibl relev role mirna earli stage follow tooth extract

D020390;D035683

T123;T023;T114

36,317,114

remimazolam requir less vasopressor support induct mainten general anesthesia patient sever aortic stenosi undergo transcathet aortic valv replac retrospect analysi singl center compar hemodynam general anesthesia remimazolam convent anesthet patient sever aortic stenosi

D065467;D015742;D018681;D001024

T061;T121;T047;T109

36,317,113

antidiarrh activ dialium guineens willd fruit pulp wistar rat studi aim evalu effect dialium guineens willd fruit pulp powder diarrhea induc castor oil wistar rat

D000930;D007887

T121;T002

36,317,112

identif valid hub gene predict treatment target immun landscap rheumatoid arthriti rheumatoid arthriti ra recogn chronic inflammatori diseas featur patholog synovi inflamm current under pathophysiolog mechan ra remain unclear studi attempt explor under mechan ra provid potenti target therapi ra via bioinformat analysi

D053263;D001172

T047;T044

36,317,111

identif differenti express gene associ prognosi diagnosi hepatocellular carcinoma integr bioinformat analysi goal studi understand possibl core gene associ hepatocellular carcinoma hcc pathogenesi prognosi

D006528;D008113

T191

36,317,110

statin anti inflamm ckd patient meta analysi random trial persist inflamm recogn import comorbid condit patient chronic kidney diseas ckd associ mani complic mortal progress ckd previous studi drawn clear conclus anti inflammatori effect statin ckd meta analysi aim assess anti inflammatori effect statin therapi patient ckd

D019161;D051436

T121;T047;T109

36,317,079

helicobact pylori infect elicit type interferon respons human monocyt via toll like receptor signal helicobact pylori colon persist could preced gastric adenocarcinoma elucid immun recognit strategi h pylori therefor imper curb chronic persist human host toll like receptor tlr tlr wide known viral singl strand rna ssrna sensor yet less studi bacteria context investig involv receptor immun h pylori human thp monocyt cell infect h pylori express level human toll like receptor tlrs examin role tlr tlr respons h pylori infect investig use receptor antagonist among tlr transcript examin tlr exhibit promin upregul follow tlr thp cell infect h pylori j ss strain h pylori infect mediat ifn ifn transactiv signific abrog tlr tlr antagonist addit tlr antagonist treatment reduc h pylori infect mediat phosphoryl interferon regulatori factor irf studi suggest novel role tlr signal host immun h pylori sens live bacteria elicit product type interferon

D016481;D007370;D009000;D051200

T129;T121;T116;T025;T192;T047

36,317,077

multiscal traffic sign detect method complex environ base yolov traffic sign detect challeng problem field unman drive particular import complex environ propos method base improv look yolo v detect recogn multiscal traffic sign complex environ method employ imag preprocess modul classifi denoiz imag complex environ input imag improv yolov also design improv featur pyramid structur replac origin featur pyramid yolov structur use adapt featur fusion modul multiscal featur transfer mechan reduc putat inform loss featur map generat process improv inform transfer deep shallow featur enhanc represent abil featur pyramid final use eiou loss cluster nms improv model perform experiment result fusion tsinghua tencent k collect dataset show propos method achiev map compar exist method method demonstr superior regard traffic sign detect

D000465

T170

36,317,076

fast polynomi time approxim solut knapsack problem knapsack problem kp np hard approxim solut vital solv kp exact paper fast polynomi time approxim solut fptas propos kp fptas local search algorithm best approxim solut kp found neighborhood solut upper bound exact k item knapsack problem e k kp k near critic item fptas practic often achiev high accuraci high speed solv kp comput experi show approxim algorithm kp valid

D000465;D011340

T170;T041

36,317,075

multi level approach segment interstiti lung diseas ild pattern classif base superpixel process fusion k mean cluster spfkmc covid pandem huge interstiti lung diseas ild lung imag captur high time develop effici segment techniqu util separ anatom structur ild pattern diseas infect level identif effect diseas classif direct depend accuraci initi stage like preprocess segment paper propos hybrid segment algorithm design ild imag take advantag superpixel k mean cluster approach segment superpixel imag adapt better irregular local spatial neighborhood help improv perform k mean cluster base ild imag segment overcom limit multiclass belong semiadapt wavelet base fusion appli select k mean cluster perform propos spfkmc compar class fuzzi c mean cluster fcm k mean cluster term accuraci jaccard similar index dice similar coeffici spfkmc algorithm give accuraci dsc jsi propos fuse cluster give better result compar tradit k mean cluster segment wavelet base fuse cluster result

D000086382;D017563

T047;T067

36,317,074

improv efficientnetv model base visual attent mechan applic identif cassava diseas characterist high recognit rate strong network robust convolut neural network becom mainstream method field crop diseas recognit aim problem insuffici number label sampl complex background sampl imag difficult extract use featur inform novel algorithm propos studi base attent mechan convolut neural network cassava leaf recognit specif combin data augment strategi dataset use prevent singl distribut imag dataset pdrnet plant diseas recognit network combin channel attent mechan spatial attent mechan propos algorithm design follow first attent modul embed network layer deploy establish remot depend featur layer strengthen key featur inform suppress interfer featur inform background nois second stochast depth learn strategi formul acceler train infer network final transfer learn method adopt load pretrain weight model propos studi recognit accuraci model enhanc mean detail paramet adjust dynam chang learn rate larg number compar experi demonstr propos algorithm deliv recognit accuraci cassava diseas imag dataset reach state art level among cnn base method term accuraci

D002365

T002

36,317,061

anticanc effect polyphyllin suppress stem cell like properti hepatocellular carcinoma via aktgsk catenin signal pathway polyphyllin ppi also call chong lou saponin steroid saponin isol rhizom pari polyphylla ppi demonstr strong anticanc activ howev effect stem liver cancer stem cell lcscs complet understood herein aim investig effect ppi stem cell like featur lcscs hepatocellular carcinoma hcc lcscs enrich serum free medium treat ppi sorafenib sora ppi sora sever endpoint includ spheroid format differenti cell prolifer surfac marker lcscs ppi bind target stem associ protein express evalu immunofluoresc stain quantit real time polymeras chain reaction sirna transfect coimmunoprecipit ubiquitin assay conduct depth mechanist studi evalu vivo antitumor efficaci demonstr ppi effect inhibit prolifer liver cancer cell self renew differenti lcscs flow cytometri indic ppi suppress express stem cell surfac marker epcam cd molecular dock show high affin ppi protein wnt catenin signal pathway includ akt gsk catenin bind energi kcalmol respect suggest ppi might regul wnt catenin signal pathway affect stem cell like properti hcc ex vivo experi impli ppi activ aktgsk mediat ubiquitin proteasom degrad catenin subsequ attenu prooncogen effect lcscs final anticanc properti ppi confirm vivo found ppi inhibit tumor growth hcc cell line xenograft model taken togeth molecular dock analysi experiment data highlight novel function ppi suppress stem cell like characterist lcscs via aktgsk catenin signal pathway

D006528;D008113;D012503

T191;T109

36,317,060

nfkb gene mutant associ prognosi coronari arteri diseas exacerb endotheli mitochondri fission dysfunct endotheli apoptosi core patholog chang atherosclerot cardiovascular diseas includ coronari arteri diseas cad determin molecular mechan under endotheli apoptosi import nuclear factor kappa b nf b crucial transcript factor control apoptosi previous studi demonstr attg insdel mutant promot nfkb gene rs risk factor cad present studi found nfkb rs polymorph posit associ increas major advers cardiac cerebrovascular event macc cad patient adjust confound factor includ age smoke hypertens glucos low densiti lipoprotein cholesterol mutant dd genotyp independ predictor macc ci p vitro studi show mutant human umbil vein endotheli cell dd mutant huvec suscept high glucosepalmit induc apoptosi accompani decreas p express increas express cleav caspas cytochrom c phospho p p mitochondri membran potenti signific lower increas level mtros open mptp observ dd mutant huvec p furthermor percentag cell fragment spheric mitochondria signific higher dd mutant huvec wild type cell genotyp ii huvec p addit stimul high glucosepalmit nfkb gene mutant signific increas express drp indic nfkb gene mutant affect express mitochondri morpholog relat protein lead excess mitochondri fission conclus mutant dd genotyp nfkb gene independ predictor wors long term prognosi cad patient dd mutant huvec exhibit abnorm activ nf b pathway increas drp express caus excess mitochondri fission dysfunct ultim lead increas apoptosi

D003324

T047

36,316,984

nt afraid eat whole whale use mix method enhanc learn leadership research assess purpos articl identifi proper use mix method leadership research assess articl highlight research assess question best serv mix method offer practition friend guid exampl integr quantit qualit data help eat whole whale one bite time sound decis make design execut present mix method studi outcom assess produc better output great increas likelihood public reput journal b sound program evalu decis c public consumpt studi assess result

D007857;D014907

T078;T015;T054

36,316,983

qualit inquiri leadership develop overview practition scholar articl serv overview qualit inquiri leadership develop practition scholar new experienc begin discuss need qualit inquiri creat knowledg leadership develop overview design compon includ exampl research assess conclud discuss qualiti standard qualit inquiri provid suggest futur direct

D007857

T078;T054

36,316,982

address known unknown student leader develop articl highlight current state know know student leadership develop suggest specif research agenda program assess method articl includ practic descript rigor method could use address issu use exampl research program assess staff descript conceptu model could employ organ leadership program outcom evalu

D007857;D013334

T078;T081;T098;T054

36,316,980

go gold hurdl win strategi conduct longitudin nonlinear research undergradu leader develop articl make case longitudin non linear method research evalu student leadership develop primer longitudin methodolog barrier align solut methodolog challeng present

D007857

T078;T054

36,316,979

assess leadership develop group organ articl discuss consider methodolog leadership educ assess leadership develop group organ use group unit analysi rather aggreg individu score

D007857;D009938

T078;T092;T054

36,316,978

soft tyranni p valu quantit research new consider leadership research articl author discuss process use quantit research render judgment decis result statist analys highlight p valu repres p valu becam ubiquit quantit social scienc research suggest altern way measur signific quantit outcom leadership research also offer

D007857

T078;T054

36,316,977

form follow function research assess design leadership learn articl discuss design research follow question studi seek address articl provid practic divers exampl broad research question applic research program architect summar differ method employ respond

D007857;D007858

T078;T061;T062;T054;T041

36,316,976

assess evalu research balanc ident purpos leadership learn articl explor aspect research assess program evalu qualiti good practic relat share mani similar differ author propos framework consist evalu applic various way studi improv leadership learn local global level

D007857;D007858

T078;T061;T062;T054;T041

36,316,975

room address represent leadership learn research articl explor particip leadership learn initi higher educ repres research assess evalu articl use leadership educ explor conduct leadership research assess evalu scholarship ie posit factor may influenc method find

D007857;D007858

T078;T061;T062;T054;T041

36,316,974

critic transform approach leadership evalu research articl author summar critic transform theori along goal describ approach particular relev within field student leadership develop applic critic transform approach conduct research program evalu effort leadership communiti develop use practic exampl within postsecondari educ also share

D007857

T078;T054

36,316,973

challeng possibl solut adapt virtual recruit lesson learn survey studi covid pandem covid pandem requir rapid chang research protocol includ immedi transit recruit research particip conduct inform consent process virtual case studi detail challeng research team face adapt person behavior intervent survey studi virtual recruit reflect impact rapid chang recruit retent discuss protocol chang made address challeng need potenti enrol particip propos recommend futur work use comput technolog display profession return phone number flexibl contact potenti particip various mean minim email communic due ad regulatori requir partner institut review board shorten improv consent document process critic studi success case studi offer insight research navig similar process virtual recruit like continu import ensur facilit rather hinder equit recruit practic

D000086382

T047;T067

36,316,972

particip perspect payment research particip qualit studi investig common offer payment research particip promot recruit retent yet ethic offer monetari incent research particip continu debat prior conceptu work address concern howev also need empir evid understand effect payment particip report result qualit studi compris discours analysi recruit convers studi coordin potenti particip actual clinic trial semistructur interview particip address effect incent decis make mani particip report money motiv enrol clinic trial use reason suggest undu influenc unjust induc find add grow bodi literatur suggest payment ethic accept tool promot recruit retent clinic trial

D009042;D035842

T078;T098;T041;T080

36,316,971

demonstr project transit research network new singl irb platform sinc nation institut health nih mandat use singl irb sirb multicent research institut struggl operation process demonstr project univers utah trial innov center assist collabor pediatr critic care research network transit use individu negoti relianc agreement paper base document new sirb master agreement informat platform captur relianc document lesson learn guid academ institut irb operation sirb includ need site understand type engag relianc requir need understand differ relianc activ requir around local review remain poor understood research need determin approach achiev nih vision review becom effici improv studi start time reliev administr burden advanc human research protect

D028744;D009316

T093;T097

36,316,970

ethic framework disclosur alzheim diseas biomark research particip conflict norm nuanc polici frequent clinic trial alzheim diseas ad target cognit unimpair individu increas risk develop diseas alway clear whether ad biomark inform disclos research particip one hand research particip may interest learn inform perceiv util hand learn inform may harm effect prevent therapeut option avail ad articl bring togeth three separ set ethic guidanc literatur return individu research result individu right access person data transpar enrol clinic trial base literatur suggest polici disclosur ad biomark test result longitudin observ cohort studi clinic trial hybrid research project european prevent alzheim dementia epad project serv ethic team also present critic discuss recommend disclosur ad biomark practic underscor long clinic valid ad biomark remain limit good reason avoid activ disclos cognit unimpair research particip

D000544

T047;T048

36,316,965

questionnair base studi patient poland evalu cours inflammatori bowel diseas effect covid pandem qualiti life mental state februari june background covid pandem affect mani peopl worldwid includ chronic diseas object analyz influenc medic care cours inflammatori bowel diseas ibd poland materi method patient poland ibd complet origin anonym questionnair impact covid pandem cours diseas mental status print questionnair distribut ibd patient treat gastroenterolog outpati clinic univers clinic hospit biaystok onlin questionnair sent patient via social media statist analysi perform use chi squar test signific level p result studi group consist women men mean age year fifti nine patient ulcer coliti crohn diseas patient report signific deterior medic avail restrict access gastroenterolog outpati clinic p patient contract covid requir hospit asymptomat mild moder despit immunosuppress biolog treatment steroid respond state pandem negat affect mental state associ worsen ibd conclus pandem respond main concern difficulti access gastroenterolog clinic limit drug avail pandem negat affect patient mental state case covid diseas patient ibd most asymptomat requir hospit despit therapi affect immun system

D000086382;D015212

T047;T067

36,316,964

central retin vein occlus discontinu rivaroxaban therapi young patient covid pulmonari embol case report background present report first case best knowledg central retin vein occlus crvo occur day anticoagul discontinu patient histori pulmonari embol cours covid case report previous healthi year old man hospit april sever covid pneumonia complic segment subsegment pulmonari embol patient treat concurr combin remdesivir dexamethason therapeut enoxaparin ceftriaxon passiv oxygen therapi convalesc plasma therapi led pulmonari improv treatment therapeut enoxaparin mg ml twice day continu month discharg follow mg rivaroxaban twice day week mg rivaroxaban day week within day rivaroxaban discontinu patient experienc decreas visual acuiti right eye level nonischem crvo cystoid macular edema diagnos intravitr inject ranibizumab perform common identifi factor contribut crvo exclud treatment prophylact enoxaparin initi two week later macular edema decreas signific visual acuiti improv treatment enoxaparin discontinu conclus rebound hypercoagul discontinu rivaroxaban therapi manifest crvo young patient histori covid pulmonari embol success treat intravitr inject ranibizumab

D012170;D000086382;D008269;D011655

T047;T046;T067

36,316,951

effect novel techniqu sensit skin treatment optim puls technolog clinic studi photomodul non phototherm effect mobil energi regul cell activ mitochondri level use treat sensit skin ss recent year base photomodul effect optim puls technolog opt develop novel treatment mode advanc opt low energi three puls long puls width aopt ltl treatment facial ss evalu effect

D015595

T033;T042

36,316,948

dissemin cryptococcosi mimick malign lymphoma f fdg petct case report dissemin cryptococcosi extrem rare easili misdiagnos malign lymphoma f fluorodeoxyglucos positron emiss tomographi pet comput tomographi ct may use assess involv dissemin cryptococcosi evalu residu diseas treatment

D008223;D003453

T047;T191

36,316,947

prospect analysi concentr ohd northern southern district japan year round studi although osteoporot patient alreadi recogn low volum vitamin status concentr activ vitamin precursor studi detail trial aim clarifi concentr hydroxyvitamin ohd natur type vitamin compar separ area japan compar clarifi concentr ohd separ area japanes patient diagnos osteoporosi base bone miner densiti studi analyz differ hospit patient whose resid separ northern district akita citi north latitud southern district shizuoka citi north latitud complet differ daylight hour three hundr sixti eight patient akita shizuoka enrol trial compar differ concentr ohd welch test signific differ concentr ohd age akita patient signific higher shizuoka patient despit shizuoka much daylight hour akita conclus might relationship concentr ohd exposur sunlight

D010024;D014808

T047

36,316,946

immedi postop lumbar spine magnet reson imag correl postop pain lumbar microdiscectomi magnet reson imag mri extens use manag patient herniat lumbar disc nevertheless immedi postop mri becom standard procedur limit research suggest find often similar preoper mri symptomat asymptomat patient studi aim determin benefit immedi postop mri patient without postop symptom correl symptom total patient underw lumbar spine microdiscectomi institut includ patient previous spinal surgeri lumbar fusion exclud patient data collect medic record mri perform day surgeri assess neurosurgeon minim bias immedi postop mri result show dural sac compress foramin stenosi patient postop pain pain free among patient without find mr imag postop pain immedi postop mri correl postop pain p intraop bleed charlson comorbid index cci show signific correl postop pain p respect multivari analysi intraop blood loss cci independ correl postop pain p respect base find intraop blood loss cci appear factor may predict persist postop pain despit normal find mri

D016063;D008159

T023;T046

36,316,945

impair rate depend depress h reflex type diabet prediabet overweight obes cross section studi type diabet chronic metabol disord character hyperglycemia result deficit insulin secret insulin resist accord intern diabet feder approxim million peopl suffer condit rapid increas impact low middl incom countri obes well known risk factor diabet current data project continu increas diabet preval worldwid obes individu among common complic diabet peripher neuropathi dpn caus sensori symptom includ pain contribut foot ulcer control limb amput may occur diagnosi dpn clinic problem rate depend depress rdd hoffmann reflex lower limb propos test determin presenc neuropath pain subject type type diabet recent impair rdd describ obes diabet rodent model studi character rdd evalu h reflex hz patient type diabet mellitus tdm control without diabet subsequ classifi overweightobes prediabet signific decreas rdd h reflex found tdm subject hz p stimul frequenc compar control hz p major find studi impair rdd also found overweight obes subject least stimul frequenc classifi prediabet level accord hbac valu rdd h reflex could use quantit sensit tool studi tdm subpopul peripher neuropathi rdd could use screen tool combin clinic test diagnos dpn evalu progress condit

D011236;D003924;D003929;D009437

T184;T047

36,316,944

influenc geometr algebra surgic practic sleev gastrectomi singl center experi laparoscop surgeri could consid art geometr algebra howev littl studi context bariatr surgeri current studi aim explor possibl influenc concept geometr algebra surgic process overweight obes patient set laparoscop sleev gastrectomi lsg studi period clinic data subject underw lsg retrospect analyz paramet examin includ bodi mass index bmi umbil xiphoid interv u x umbil fundus u f interv studi lsg perform via central view approach c left view approach l group bodi surfac project point view hole v main accessori oper hole surfac display fundus f connect form geometr figur access surgic instrument fundus need elong instrument relat intra post oper paramet note overweight obes subject show signific increas u x u f interv compar non obes subject length u x u f interv correl bmi geometr figur quit differ l c approach signific increas area quadrangl signific longer f f v f interv calcul c approach patient thus elong instrument frequent requir integr concept geometr algebra proper select troca may provid better surgic experi smooth surgic process

D009767;D050110;D010535

T061;T060;T047

36,316,943

mind tributari canal stent necessari insulinoma enucl proxim promin duct santorini case report literatur review describ case insulinoma locat extrem close accessori pancreat duct apd away main pancreat duct mpd previous studi show insulinoma enucl safe procedur small benign tumor mm distant mpd howev case enucl tumor led unanticip apd injuri grade b post oper pancreat fistula popf provid detail record clinic manag argu enucl tumor near apd need care weigh

D007340;D010190

T191

36,316,942

decis curv analysi identifi optim candid liver resect intermedi stage hepatocellular carcinoma hepat b cirrhosi cohort studi select criterion liver resect lr intermedi stage im hepatocellular carcinoma hcc still controversi studi aim compar lr transarteri chemoembol tace rang predict death risk multivari cox regress model mvr estim predict mortal year cutoff valu determin piec wise linear regress model decis curv analysi mvr model hazard ratio curv treatment plot predict mortal im hepatocellular carcinoma im hcc hepat b cirrhosi includ analysi tace n lr n year overal surviv os rate lr patient higher tace group vs p ci predict death risk decis curv analysi suggest lr tace increas net benefit patient divid subgroup cutoff valu stratifi analysi treatment differ subgroup hazard ratio ci ci ci ci respect lr reach maxim relat util interv lr tace increas net benefit year death risk

D006528;D016461;D008113;D006509

T061;T047;T191

36,316,941

role sarcopenia treatment relat outcom patient renal cell carcinoma systemat review meta analysi recent year attent paid fuzzi relationship skelet muscl compon renal cell carcinoma rcc studi attempt conduct meta analysi use relev research evid explor impact sarcopenia final surviv recurr outcom rcc patient chang process impact treatment

D002292;D055948;D007680

T047;T191

36,316,940

unprep hiv prevent servic hesit among us primari care provid provis hiv prevent servic primari care pcp healthcar provid critic reduc number new hiv infect examin perform hiv risk assess provis hiv prevent servic pcps cohort less one half respond ask sex drug use time among routin ask sex drug use respect would ask given time less quarter respond note hiv prevent servic part clinic practic find demonstr gap provis hiv prevent servic key popul healthcar provid

D015658;D000163

T047

36,316,939

effect tradit chines medicin base rehabilit nurs combin scalp acupunctur negat emot qualiti life patient stroke random control trial studi aim analyz effect tradit chines medicin base rehabilit nurs combin scalp acupunctur tcmrn sa negat emot qualiti life patient stroke

D019145;D015670;D020521

T061;T047;T091

36,316,938

effect glp receptor agonist asprosin level normal weight overweightobes patient type diabet mellitus asprosin newli identifi adipokin glucos rais appetit enhanc effect act differ known hepat glucos util pathway studi investig chang serum asprosin level normal weight overweightobes liraglutid treat patient type diabet tdm studi non random prospect observ studi metabol paramet asprosin level compar peopl tdm peopl normal glucos toler ngt treatment phase tdm patient given liraglutid dose mgd first week mgd subsequ week mgd follow week tdm patient separ normal weight group overweightobes group compar chang asprosin paramet pre post treatment tdm group signific higher fast asprosin h postprandi asprosin level ngt group p fast asprosin postprandi asprosin posit correl bmi hpg hbac tg homa ir negat correl hdl c tdm ngt group asprosin level decreas liraglutid treatment normal overweightobes tdm group p signific reduc bodi weight bmi overweightobes tdm patient p fast postprandi serum asprosin concentr higher tdm patient compar normal glucos control fast postprandi asprosin posit correl bmi hpg hbac tg homa ir negat correl hdl c particip liraglutid lower asprosin level tdm patient reduc weight bmi overweight obes type diabet

D003924;D000067757;D007333;D000071838

T123;T116;T192;T047;T046

36,316,937

risk factor dexmedetomidin associ bradycardia spinal anesthesia retrospect studi sedat dexmedetomidin need patient undergo spinal anesthesia howev dexmedetomidin sedat increas incid bradycardia aim identifi evalu risk factor bradycardia patient undergo spinal anesthesia dexmedetomidin sedat record patient underw spinal anesthesia sedat use dexmedetomidin review retrospect studi identifi characterist includ patient group underw lower leg surgeri estim blood loss ml collect detail potenti risk factor bradycardia clinic record factor includ age american societi anesthesiologist classif height weight sensori level spinal anesthesia histori hypertens diabet mellitus load mainten dose dexmedetomidin tourniquet time initi diastol systol blood pressur initi heart rate hr anesthesia surgeri durat primari endpoint studi occurr bradycardia identifi potenti risk factor use logist regress analysi incid bradycardia obtain patient initi hr tourniquet time signific individu predict factor occurr bradycardia logist regress analysi show adjust baselin hr durat tourniquet use risk factor bradycardia patient monitor undergo spinal anesthesia sedat use dexmedetomidin bradycardia long tourniquet time low initi hr could also predict factor bradycardia

D000775;D020927

T061;T121;T109

36,316,936

delay diagnosi manag necrot fasciiti left lower leg case report necrot fasciiti nf rare sever soft tissu infect character rapid extens necrosi skin subcutan tissu superfici deep fascia frequent misdiagnos infecti diseas lead inappropri treatment potenti serious consequ may complic septic shock multipl organ failur fatal outcom

D019115;D012772

T047;T046

36,316,935

prognost nutrit index outcom predictor patient iliopsoa abscess case iliopsoa abscess ipa singl hospit base case review compar clinic profil publish hospit base ipa seri verifi use prognost nutrit index pni use predict outcom sever ipa studi perform studi consist part studi case review ipa seri singl hospit case ipa treat singl hospit sequenti year collect seri clinic profil compar studi review hospit base literatur search pubm databas present perform use boolean express psoa iliopsoa abscess hospit base two hospit base case seri collect clinic profil seri compar seri draw predict factor outcom decid treatment modal medic surgic studi analyz ipa case averag age year old vari lifesav rate pni calcul serum albumin alb total lymphocyt count larger cumul abscess volum cav measur comput tomographi seem outcom predictor studi analyz hospit base ipa seri seri seri review isol ipa case without comorbid seri review ipa case cardiovascular disord among seri includ seri show oldest case longer length hospit seri show highest mortal among collect ipa cardiovascular comorbid pni seem predictor outcom diseas activ patient ipa might indic treat surgic intervent

D016659

T047