PMID
int64 35.7M
36.4M
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36,315,526
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justif research use systemat review continu inconsist clinic health scienc systemat review meta analysi meta research studi redund uneth unscientif cost challeng clinic health research high risk redund exist evid use justifi research question new studi initi therefor aim studi synthes meta research studi evalu author clinic health research studi use systemat review initi new studi
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D058028
|
T170
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36,315,525
|
alter microvasculatur pancreat islet subject type diabet transcriptom differ dissoci pancreat islet cell describ enzymat isol islet health diseas howev isol cultur dissoci procedur like affect transcriptom profil distort biolog conclus aim current studi character cell islet langerhan subject without type diabet way reflect vivo situat highest possibl extent
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D003922;D007515;D050417
|
T047;T025;T023
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36,315,523
|
interact malaysian childhood healthi lifestyl machel intervent programm chang weight relat behaviour preschool child parent dyad studi protocol cluster randomis control trial unhealthi weight especi childhood obes emerg grow epidem challeng develop develop countri partnership parent promot healthi lifestyl chang may lifelong impact weight relat outcom children studi aim determin efficaci interact malaysian childhood healthi lifestyl machel intervent programm chang weight relat behaviour preschool child parent dyad
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D063766
|
T033;T047
|
36,315,522
|
network base method psychometr data eat disord systemat review network scienc repres power increas promis method studi complex real world problem last decad appli psychometr data attempt explain psychopatholog complex system causal interconnect symptom one categori mental disord relev sever incid multifacet structur eat disord ed serious disturb negat affect person eat behavior
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D001068
|
T047;T048
|
36,315,521
|
climat edaph control soil n temper grassland northern china pls path analysi identifi impact path climat soil factor soil n crucial better understand n turnov soil integr inform ecosystem n cycl mani studi show climat soil variabl influenc chang soil n howev exist studi focus overal impact factor soil n without distinguish direct indirect effect although scholar studi relationship among temperatur precipit soil n soil ph soil n rather estim causal relationship simultan answer mention question region scale soil collect conduct across temper grassland northern china meanwhil pls path analysi util evalu direct indirect effect various factor soil n explor causal relationship among variabl result show along transect mean annual precipit map mean annual temperatur mat direct signific reduc soil n indirect affect soil n effect soil ph soil clay soil n soil cn soil cn ratio signific direct impact soil n negat correl soil clay soil n content soil ph total posit effect soil n total posit impact soil ph weak negat indirect impact soil n affect soil clay soil n soil cn ratio total influenc order map mat soil cn soil clay soil n soil ph absolut valu result provid valuabl inform ecosystem n cycl temper grassland northern china
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D012987;D065948
|
T082;T167
|
36,315,520
|
tempor event detector pregnanc care ted pc rule base algorithm infer gestat age deliveri date electron health record pregnant women without covid identifi time sar cov viral infect relat specif gestat week critic delin role viral infect time advers pregnanc outcom howev task difficult come electron health record ehr combat covid pandem matern health sought develop valid clinic inform extract algorithm detect time clinic event relat gestat week
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D000086382;D011251;D047928
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T047;T046;T067
|
36,315,519
|
bromopalmit decreas spinal inflamm attenu oxaliplatin induc neuropath pain via reduc drp mediat mitochondri dysfunct oxaliplatin oxa third generat platinum compound clinic activ multipl solid tumor due repetit chemotherapi cycl oxa induc chronic neuropathi present paresthesia pain studi explor neuropathi chemotherapi pain investig analges effect bromopalmit bp pain behavior oxa induc rat chemotherapi pain rat model establish five consecut administr oxa intraperiton mgkg establish oxa induc rat pain behavior test inflammatori signal analysi mitochondri function measur conduct oxa induc rat exhibit mechan allodynia spinal inflammatori infiltr fluoresc western blot analysi reveal spinal astrocyt activ oxa rat regul astrocyt marker addit nod lrr pyrin domain contain nlrp inflammasom mediat inflammatori signal cascad also activ inflamm trigger dysfunct mitochondria repres increas cyclooxygenas cox level manganes superoxid dismutas mn sod activ intrathec inject bp signific attenu dynamin relat protein drp mediat mitochondri fission recov mitochondri function suppress nlrp inflammasom cascad consequ decreas mechan pain sensit cell research bp treatment signific revers tumor necrosi factor tnf induc mitochondria membran potenti defici high reactiv oxygen speci ros level find indic bp decreas spinal inflamm reliev oxa induc neuropath pain via reduc drp mediat mitochondri dysfunct
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D058847;D009437
|
T123;T047;T116;T184
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36,315,517
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one health genom surveil respons univers base outbreak sar cov delta ay lineag arizona genom surveil wastewat track strategi use strengthen public health respons outbreak sar cov delta ay lineag associ univers campus arizona epidemiolog clinic data routin gather contact trace match sar cov genom belong outbreak ay identifi ongo phylogenom analys continu phylogenet analys conduct describ ay outbreak wastewat collect twice week site across campus test sar cov rt qpcr subsequ sequenc identifi variant ay outbreak defin singl mutat ct compris genom sar cov posit case associ univers communiti sever undergradu student gather congreg live set campus like contribut rapid spread covid across univers secondari transmiss communiti clade defin mutat also found wastewat sampl collect around student dormitori week semest began day case identifi genom epidemiolog wastewat surveil provid evid ay clone like import univers set prior onset fall semest rapid spread subset student popul subsequ spillov occur surround communiti univers local public health depart work close togeth facilit time report case identif close contact necessari respons mitig strategi emerg new sar cov variant potenti threat infecti diseas outbreak univers campus present opportun futur comprehens one health genom data driven target intervent
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D000086382;D000074823
|
T078;T047;T067
|
36,315,516
|
pcr free rapid protocol one pot construct high divers genet librari vitro protein display method access extens librari eg play increas import role protein engin howev prepar larg librari remain labori time consum process report effici one pot ligat elong l e method sizeabl synthet librari prepar free pcr amplif purif step proof concept construct ankyrin repeat protein templat synthet librari variant l volum entir process oligo dna templat readi transcript linear scalabl took mere minut believ l e method signific simplifi prepar synthet librari acceler vitro protein display experi
|
D015202
|
T063
|
36,315,514
|
inequ fair heterogen endow peopl differ intellig cognit abil person trait motiv similar valu larg degre inherit characterist determin success achiev individu heterogen lead fair distribut reward outcom develop question theoret test experiment set structur condit specif interact situat first catalogu function relationship individu endow outcom distinguish fair concept meritocraci equal opportun equal outcom rawl theori justic use onlin experi studi fair pattern emerg differ endow individu share resourc other depend whether inform other endow outcom avail find visibl outcom lessen inequ decreas statist dispers outcom across group endow need visibl better equal opportun disadvantag
|
D012201;D005376
|
T081;T041;T057
|
36,315,513
|
hereditari variant unknown signific african american women breast cancer expand implement genet sequenc precipit increas discoveri germlin somat variant direct benefit identifi variant action gene may lead risk reduct strategi increas surveil prophylact surgeri well lifestyl modif reduc morbid mortal howev patient african ancestri like receiv inconclus genet test result due increas number variant unknown signific decreas util impact diseas manag prevent studi examin whole exom sequenc result germlin dna sampl african american women famili histori cancer includ case diagnos breast cancer famili member self identifi ancestri valid compar genom popul analysi sequenc result limit gene three clinic avail common genet screen platform target region total variant pathogen like pathogen benign classifi variant unknown signific averag variant unknown signific per individu individu harbor least one target gene pathogen like pathogen variant found individu brca prfs rs brca pkfs rs plfs rs rad pef rs atm pvg rs mutyh pgd rs gene strategi function valid remain variant unknown signific especi understudi hereditari cancer popul great need increas clinic util util clinic genet screen platform reduc cancer incid mortal
|
D001741;D001943
|
T098;T191
|
36,315,512
|
integr analysi lncrna gene express longissimus dorsi muscl two development stage hainan black goat deem meat qualiti kid better adult hainan black goat general meat qualiti affect mani indic intramuscular fat imf content muscl fiber diamet shear forc indic long non code rnas lncrnas play essenti role meat qualiti goat howev unclear whether lncrnas gene play role meat qualiti hainan black goat first compar meat qualiti two month old kid kid adult goat adult lncrna seq rna seq data integr analyz explor potenti function lncrnas gene result show adult imf content muscl fiber diamet extrem signific higher kid p sequenc data averag clean read obtain respect kid adult among map refer genom goat analyz goat annot gene goat annot lncrnas novel lncrnas obtain analysi differenti express gene deg lncrnas del show deg del exist kid adult furthermor function enrich analysi reveal number deg del main associ imf primarili dgat express higher adult kid cpta express higher kid adult overlap deg target del suggest two deg del target two deg might potenti regul goat imf deposit taken togeth result provid basic support understand function mechan lncrnas gene meat qualiti hainan black goat
|
D006041;D062085
|
T123;T015;T114
|
36,315,511
|
associ cognit function larg optic nerv cup account cup disc ratio genet risk score investig account cup disc ratio cdr genet risk score grs modifi associ larg cdr cognit function among women
|
D009898;D005901
|
T033;T023;T047
|
36,315,510
|
ethyl deoxyuridin fragil klebsiella pneumonia outer wall facilit intracellular kill phagocyt cell klebsiella pneumonia causat agent varieti sever infect mani k pneumonia strain resist multipl antibiot situat creat need new antibacteri molecul k pneumonia pathogen reli larg abil escap phagocytosi intracellular kill phagocyt cell interf escap mechan may allow decreas bacteri virul combat infect studi use dictyostelium discoideum model phagocyt screen collect chemic compound phga ko discoideum cell feed upon k pneumonia bacteria unless bacteria bear mutat decreas virul identifi non antibiot compound restor growth phga ko cell k pneumonia character mode action one ethyl deoxyuridin k k treat bacteria rapid kill discoideum phagosom non treat bacteria sensit polymyxin outer membran access hydrophob fluoresc probe result suggest k act render membran k pneumonia access antibacteri effector k effect three differ k pneumonia strain act concentr low k previous use treat viral infect precis molecular mechan action k pneumonia remain determin
|
D004023;D007710
|
T047;T204
|
36,315,509
|
percept experi clinician caregiv treat childhood sever pneumonia hypoxemia use bubbl continu posit airway pressur ethiopian tertiari general hospit low middl incom countri lmic sever pneumonia hypoxemia lead caus child death even provis recommend antibiot therapi oxygen therapi support care previous studi found posit outcom use bubbl continu posit airway pressur bcpap treat children compar standard oxygen therapi due lack data percept experi hospit health care worker caregiv children feasibl accept bcpap treat children sever pneumonia hypoxemia real life set examin issu tertiari general hospit ethiopia
|
D045422;D011014
|
T061;T047;T050
|
36,315,507
|
patient knowledg medicin improv provid written compar verbal inform nativ languag patient knowledg medicin prescrib vital reduc medic error improv adher patient satisfact studi assess patient knowledg medicin prescrib compar improv follow verbal written inform given patient languag
|
D007802;D017060
|
T171;T080
|
36,315,506
|
current distribut distribut polar cochlear implant stimul mode measur situ oticon medic cochlear implant use stimul mode call distribut polar dap connect non stimul avail intracochlear electrod extracochlear refer electrod result complex distribut current yet undescrib present studi aim provid first character current distribut neuro zti modifi allow measur current return electrod dap stimul implant ex vivo human head map distribut current creat differ stimul condit differ charg level result show averag current return extracochlear refer electrod remain distribut intracochlear electrod posit stimul electrod chang ratio current extracochlear return case first basal electrod apic mid posit electrod observ increas charg level led small signific chang ratio current extracochlear return measur increas charg level nc research need show dap yield better speech understand stimul mode
|
D003054;D019929
|
T061;T074
|
36,315,505
|
rural urban differ initi oral anticoagul therapi patient incid atrial fibril finnish nationwid cohort studi littl known rural urban differ treatment outcom patient atrial fibril af aim assess whether initi oral anticoagul oac therapi patient af differ rural urban resid
|
D001281;D020521
|
T047;T046
|
36,315,502
|
preval corneal find interrel hematolog find monoclon gammopathi determin preval paraproteinem keratopathi ppk among patient monoclon gammopathi mg evalu interrel corneal hematolog paramet patient ppk
|
D003316;D003318;D008998;D009101;D010265
|
T033;T047;T191
|
36,315,501
|
radiat vs surgeri earli stage laryng verruc carcinoma popul base propens score match studi verruc carcinoma vc rare variant squamous cell carcinoma although vc consid radioresist concret evid absent
|
D018289;D006258
|
T191
|
36,315,499
|
percutan pericardi cathet drainag symptomat urem pericardi effus narrow safeti margin percutan pericardi cathet drainag pcd pericardi effus general known limit high risk associ effus less mm thick object report case underw percutan pcd symptomat urem pericardi effus less mm thick cardiologist declin perform pcds narrow safeti margin
|
D010490
|
T047;T046
|
36,315,497
|
ultrafast polym dynam nanopor ultrathin nanopor sensor allow singl molecul polym measur sub microsecond time resolut enabl high current signal na demonstr first time experiment probe ultrafast transloc fold dynam doubl strand dna dsdna nanopor mhz bandwidth acquisit data point per ns mbs introduc rigor algorithm abl accur identifi current level present within transloc event elucid dynam fold unfold behavior remark sensit system reveal distort short live fold state lower bandwidth work revisit probe dsdna model polym develop broad applic method combin improv sensor signal instrument larg data analysi method uncov biomolecular dynam unpreced small time scale
|
D058608
|
T082
|
36,315,496
|
lightweight mobil network real time violenc recognit exist violenc recognit method complex network structur high cost comput meet requir larg scale deploy purpos paper reduc complex model realiz applic violenc recognit mobil intellig termin solv problem propos mobilenet tsm lightweight network use mobilenet v main structur incorpor tempor shift modul tsm exchang inform frame capabl extract dynam characterist consecut frame strengthen extens experi conduct prove valid method propos model mb paramet mb estim total size compar exist method method great reduc model size cost accuraci gap propos model achiev accuraci three public dataset crowd violenc hockey fight rwf respect base also build real time violenc recognit applic android termin sourc code train model avail https githubcommobilenet tsmgit
|
D014754
|
T048
|
36,315,495
|
differenti immedi long term effect nitrogen input denitrif non ratio along soil profil high nitrogen n input soil caus higher nitrous oxid emiss higher non ratio inhibit reductas activ andor decreas soil ph assum two mechan effect n input emiss immedi long term effect immedi effect field appli fertil n elimin decreas n input long term effect soil accumul n caus long term fertil therefor import separ effect mitig emiss end soil sampl along profil collect long term n fertil experi field two n applic rate kg n ha year n fertil n input n extern n addit conduct subsampl laboratori incub studi produc two addit treatment denot nn nn treatment result show combin immedi long term effect led increas non ratio approxim increas could explain immedi long term effect n input respect meanwhil long term effect signific posit correl soil organ carbon soc result indic excess n fertil input soil lead increas emiss soil high soc content long term effect n input non ratio consid predict soil emiss global environment chang scenario
|
D009609;D012987
|
T123;T197;T121;T167
|
36,315,494
|
anxieti depress among patient companion admiss icu omicron wave covid cross section studi aleppo univers hospit covid pandem anxieti depress reach high level especi last wave omicron healthcar worker contact covid patient come contact may exhibit high level anxieti depress therefor aim assess anxieti depress symptom among icu companion covid patient
|
D000086382
|
T047;T067
|
36,315,493
|
determin life satisfact among women reproduct age year bangladesh cross section analysi life satisfact women essenti compon subject well indic woman life qualiti base person percept consid import women subject well unit nation un recogn one sustain develop goal sdgs best knowledg studi done yet bangladeshi women age year use nation repres data studi first studi knowledg identifi determin life satisfact investig associ determin life satisfact among women reproduct age year bangladesh studi examin overal life satisfact impact person sociodemograph characterist among women age year bangladesh use multipl indic cluster survey mic data cross section data studi inform regard life satisfact avail sampl women categor variabl overal life satisfact adjust miss valu variabl overal life satisfact categor three categori name low moder high accord organis econom co oper develop oecd guidelin result show women low satisfi moder satisfi high satisfi live bivari analysi appli studi show signific associ determin life satisfact multinomi logist regress analysi perform draw valid conclus effect potenti determin life satisfact studi reveal satisfact increas age educ level wealth status variabl marit status three categori current marri former marri never marri current marriag strong associ higher life satisfact contrast former marriag never marriag associ lower life satisfact migrat status also signific associ life satisfact women chang locat satisfi never chang current locat bangladesh aim achiev sustain develop goal sdgs achiev sustain develop goal sdg promot well goal empow women girl address issu relat life satisfact appli appropri intervent must
|
D010549;D008393
|
T080;T055;T033;T062;T079;T054;T081;T072;T041
|
36,315,492
|
optim sequenc base design multi antigen hiv vaccin use minim distant antigen immens global divers hiv signific obstacl develop safe effect vaccin recent show infect establish multipl founder variant associ develop neutral breadth year later propos novel vaccin design strategi integr variabl observ acut hiv infect multipl founder variant develop probabilist model simul variabl yield set sequenc present minim divers seen infect multipl founder appli model subtyp c consensus sequenc envelop env use input show simul env sequenc mimic mutat landscap infect multipl founder variant includ divers antibodi epitop deriv set multi founder variant like minim distant antigen design use vaccin cocktail specif hiv subtyp circul recombin form expect promot develop broad neutral antibodi
|
D015497;D016915;D015658
|
T129;T005;T121;T047
|
36,315,491
|
design novel compact high select wideband bandstop rf filter use dual path lossi reson next generat applic articl present design wideband bandstop rf filter intend improv select compact convent bandstop filter topolog finit unload qualiti factor produc degrad bandstop filter perform due dissip loss propos filter design novel dual path capacit coupl step imped reson ccsir structur use obtain infinit stopband attenu uniform imped reson use path wherea path contain reson twice coupl transmiss line electr length path chosen phase result high reject level higher frequenc analyz select improv increas order dual coupl step imped reson propos design produc wideband bsf center ghz high reject level db fraction bandwidth result demonstr reson frequenc regul vari electr length ccsir moreov realiz phase signal cancel due dual path involv produc finit frequenc transmiss pole enhanc filter select howev electr perform achiev coaxial caviti waveguid due high qualiti factor propos topolog fabric measur high frequenc microstrip substrat low qualiti factor compact output better electr perform compar coaxial caviti waveguid due high electr perform small size propos bsf appropri g g fr applic measur show good concurr full wave em simul result fabric prototyp third order bsf compact size g ghz
|
D017097
|
T039;T070
|
36,315,487
|
skinet deep learn framework skin lesion diagnosi uncertainti estim explain skin cancer consid common human malign around million new case skin cancer record unit state annual earli identif evalu skin lesion great clinic signific disproportion dermatologist patient ratio pose signific problem develop nation therefor novel deep architectur name skinet propos provid faster screen solut assist newli train physician process clinic diagnosi skin cancer main motiv behind skinet design develop provid white box solut address critic problem trust interpret crucial wider adopt comput aid diagnosi system medic practition propos skinet two stage pipelin wherein lesion segment follow lesion classif mont carlo dropout test time augment techniqu employ propos method estim epistem aleator uncertainti novel segment model name bayesian multiresunet use estim uncertainti predict segment map salienc base method like xrai grad cam guid backprop explor provid post hoc explan deep learn model isic dataset use perform experiment ablat studi result establish robust propos model tradit benchmark address black box natur model allevi skeptic medic practition incorpor transpar confid model predict
|
D000077321;D012878;D012871
|
T047;T191;T066
|
36,315,485
|
gutka consumpt dietari partial explain anemia women coastal slum karachi pakistan mix method studi limit literatur avail dietari pattern consequ health women live coastal slum karachi pakistan
|
D014030;D000740
|
T121;T109;T131;T047;T167
|
36,315,484
|
physic activ fear avoid belief level disabl multi ethnic femal popul chronic low back pain surinam popul base studi chronic low back pain clbp import caus reduc daili physic activ pa loss qualiti life especi women surinam middl incom countri south america relationship pa clbp still unknown
|
D017116;D059352
|
T033;T184;T047
|
36,315,483
|
learn diagnos common thorax diseas chest radiograph radiolog report vietnames deep learn recent time made remark stride come impress perform mani task includ medic imag process one contribut factor advanc emerg larg medic imag dataset howev exceed expens time consum construct larg trustworthi medic dataset henc multipl research leverag medic report automat extract label data major labor howev perform english work propos data collect annot pipelin extract inform vietnames radiolog report provid accur label chest x ray cxr imag benefit vietnames radiologist clinician annot data close match endem diagnosi categori may vari countri countri assess efficaci propos label techniqu built cxr dataset contain studi evalu pipelin use subset dataset f score least evalu demonstr label tool perform precis consist across class build dataset train deep learn model leverag knowledg transfer larg public cxr dataset employ varieti loss function overcom curs imbalanc multi label dataset conduct experi various model architectur select one deliv best perform best model chexpert pretrain efficientnet b yield f score ci auc sensit specif abnorm diagnosi general final demonstr coars classif base five specif locat abnorm yield compar result fine classif twelv patholog benchmark chexpert dataset general anomali detect deliv better perform term averag perform class
|
D000077321;D011871
|
T091;T066
|
36,315,482
|
impact gender mismatch corneal graft reject reject relat graft failur repeat penetr keratoplasti explor impact gender mismatch corneal allograft reject reject relat graft failur patient repeat penetr keratoplasti pk
|
D015948;D003316
|
T061;T047
|
36,315,481
|
sign languag recognit mean common spatial pattern analysi current around million hard hear peopl amount expect grow come year despit effort made communic barrier deaf hard hear signer non signer environ without interpret differ approach develop late tri deal issu work present argentinian sign languag lsa recognit system use hand landmark extract video lsa dataset order distinguish differ sign differ featur extract signal creat hand landmark valu first transform common spatial pattern csp algorithm csp dimension reduct algorithm wide use eeg system featur extract transform signal use feed differ classifi random forest rf k nearest neighbor knn multilay perceptron mlp sever experi perform promis result obtain achiev accuraci valu set sign
|
D012813;D003638
|
T033;T184;T171;T047
|
36,315,480
|
wind veloc field estim aircraft deriv data use gaussian process regress wind veloc field knowledg crucial futur air traffic manag paradigm key mani applic aircraft perform studi paper address problem spatio tempor windc veloc field estim north east wind compon within given air space estim function time wind veloc field reconstruct space past present time instant short term predict perform wind data obtain indirect state aircraft broadcast mode ad b aircraft surveil system gaussian process regress method flexibl univers estim employ solv problem general condit method statist consist mean method converg ground truth increas data avail especi interest sinc aircraft data avail expect grow futur deploy european system wide inform manag besid estim gaussian process regress method provid probabl distribut particular estim allow confid interv comput moreov spatial model perform use raw data without reli grid estim perform spatio tempor locat furthermor sinc train phase method describ paper fast requir less minut standard desktop comput use onlin continu track state wind veloc field thus allow data assimil case studi present paper gaussian process regress method test differ day differ wind intens avail data set split sever train test data set use check consist result wind veloc field reconstruct predict final gaussian process regress method valid use european centr medium rang weather forecast era meteorolog reanalysi data obtain result show gaussian process regress use reliabl estim wind veloc field aircraft deriv data
|
D014919;D008962
|
T062;T070;T170
|
36,315,477
|
character novel pyruv kinas trichinella spirali particip sugar metabol larval molt develop pyruv kinas wide exist mani parasit play import role energi product parasit pyruv kinas might potenti drug target kill parasit aim present studi evalu biolog characterist role spirali pyruv kinas tspkm sugar metabol larval molt develop spirali
|
D017160;D014235;D010271
|
T047;T204
|
36,315,471
|
molecular character zeta gene musca domestica diptera muscida role respons bacteri infect gene play import role mani biolog process includ cell surviv apoptosi signal transduct howev function homolog gene musca domestica remain unclear identifi character domestica found md gene high homolog close insect qrt pcr analysi reveal md high express adult express predomin hemocyt fat bodi meanwhil express md regul inject escherichia coli staphylococcus aureus moreov recombin protein rmd strong inhibit growth e coli aureus notabl rmd inhibit e coli aureus permeat cell membran taken togeth find suggest md involv immun respons bacteria damag cell membran
|
D006793;D009117;D001424
|
T047;T204
|
36,315,464
|
modul diffus mechan correl complex aqueous deep eutect solvent aqueous mixtur deep eutect solvent dess gain traction recent effect templat tailor physicochem properti detail microscop insight effect water molecular relax phenomenon dess entir understood dess strong network form liquid due extens hydrogen bond complex format speci therefor water behav control disruptor alter microscop structur dynam dess studi role water diffus mechan acetamid aqueous mixtur dess synthes use acetamid lithium perchlor investig use molecular dynam md simul quasielast neutron scatter qen acetamid dynam compris local diffus within transient cage jump diffus process across cage jump diffus process observ strong enhanc factor water content system increas meanwhil geometri local dynam unalt addit water local diffus becom signific faster heterogen increas water concentr acceler effect water local diffus also substanti qen experi water concentr des observ control solvat structur lithium ion ion becom signific hydrat wt water format interwat water acetamid hydrogen bond observ increas water concentr found increas number h bond howev lifetim found decreas substanti similar lifetim acetamid lithium complex also found diminish increas water concentr power law scale relationship lifetim diffus constant establish elucid extent coupl diffus process hydrogen bond microscop complex studi demonstr abil use water agent probe role structur relax complex lifetim diffus process differ time length scale
|
D000091463;D008094
|
T120;T121;T196
|
36,315,459
|
neck pain headach complic persist syringomyelia foramen magnum decompress chiari malform improv multimod chiropract therapi background patient arnold chiari malform cm treat foramen magnum decompress fmd ongo neck pain headach symptom complic persist syringomyelia yet littl research regard treatment symptom case report year old woman histori residu syringomyelia follow fmd ventriculoperiton shunt cm present chiropractor progress worsen neck pain occipit headach upper extrem numb weak gait abnorm world health organ qualiti life score qol symptom improv fmd year prior progress worsen resist form treatment includ exercis acupunctur medic examin chiropractor reveal upper extrem neurolog deficit includ grip strength chiropractor order whole spine magnet reson imag demonstr persist cervico thorac syrinx find cervic spondylosi treat patient use multimod approach gentl cervic spine mobil soft tissu manipul core finger muscl rehabilit exercis patient respond posit month follow qol score grip strength forward head posit improv abl eat use chopstick conclus case highlight patient neck pain headach persist syringomyelia fmd cm improv follow multimod chiropract rehabilit therapi given limit low level evid intervent patient persist symptom syringomyelia fmd therapi broad recommend yet could consid case case basi
|
D013595;D001139;D002684
|
T019;T047;T091
|
36,315,446
|
comprehens analysi prognost signific cadherin cdh gene famili breast cancer breast cancer one lead death kind malign therefor import earli detect primari tumor site tumor cell could take mesenchym properti term epitheli mesenchym transit emt process part regul member cadherin cdh famili gene essenti step format metastas lot studi role cdh famili gene cancer howev holist approach examin role distinct cdh famili gene develop breast cancer remain larg unexplor present studi use bioinformat approach examin express profil cdh famili gene use oncomin gene express profil interact analysi gepia cbioport metacor tumor immun estim resourc timer platform reveal cdh messeng rna level overexpress breast cancer cell compar normal cell correl poor prognos breast cancer patient distant metastasi free surviv enrich analysi show high express cdh signific correl cell adhes extracellular matrix remodel process emt wntbeta catenin interleukin mediat immun respons collect cdh thought potenti biomark breast cancer progress metastasi
|
D001943
|
T191
|
36,315,433
|
post oper electr muscl stimul attenu loss muscl mass function follow major abdomin surgeri older adult split bodi randomis control trial signific loss muscl mass function occur major abdomin surgeri neuromuscular electr stimul nmes shown reduc muscl atrophi patient group evid post oper patient limit studi assess efficaci nmes attenu muscl atrophi function declin follow major abdomin surgeri older adult
|
D004599;D053580;D009133;D052097;D011183
|
T061;T023;T046;T042
|
36,315,431
|
polypharmaci shape depend transit old find newcastl studi help older peopl maintain independ identifi risk factor compromis high import polypharmaci common old age whether shape transit depend fastest grow subpopul unclear
|
D019338
|
T061
|
36,315,430
|
associ chang diet qualiti mid life late life healthi age singapor chines health studi studi evalu associ chang diet qualiti mid life late life healthi age
|
D000073656
|
T102
|
36,315,401
|
high yield b side electron transfer k photosynthet reaction center protein rhodobact sphaeroid primari electron transfer et process k compar rhodobact sphaeroid reaction center rc pigment protein complex mutant includ wild type control engin rcs bear mutat l polypeptid larg inhibit et excit state p primari electron donor p bacteriochlorophyl dimer normal photoact side cofactor enhanc et c symmetri relat normal photoinact b side cofactor p decay multiexponenti temperatur model aris subpopul differ contribut two step et eg p p b b p h b one step superexchang et eg p p h b p ground state h b b b monomer bacteriopheophytin bacteriochlorophyl respect relat abund subpopul inher rate constant p decay rout vari temperatur regardless et produc p h b general faster k k factor key find yield p h b rang among mutant rcs essenti k k case overal result show et p b side cofactor mutant requir thermal activ involv combin et mechan analog oper side nativ rc
|
D045322;D012242
|
T123;T007;T116
|
36,315,362
|
hybrid discret continuum model approach explor impact cell infiltr anti tumour immun respons present spatial hybrid discret continuum model framework interact dynam tumour cell cytotox cell play pivot role immun respons tumour framework tumour cell cell model individu agent chemokin drive chemotact movement cell toward tumour model continuum formal deriv continuum counterpart model given coupl system compris integro differenti equat densiti tumour cell partial differenti equat densiti cell partial differenti equat concentr chemokin report comput result hybrid model show excel quantit agreement numer solut correspond continuum model result shed light mechan underli emerg differ level infiltr cell tumour elucid cell infiltr shape anti tumour immun respons moreov present proof concept idea exploit comput effici continuum model extens numer simul could carri investig impact cell infiltr respons tumour cell differ type anti cancer immunotherapi
|
D008954;D009369
|
T191;T075
|
36,315,361
|
bioclimat model face studi forecast bleak futur wheat product india sinc impact futur climat chang wheat product inconsist studi geograph distribut yield wheat use two global general circul model gcms free air co enrich face experi gcms ipsl cma lr nimr hadgem ao four repres concentr pathway rcps bioclimat variabl use distributionecolog nich model enm current cultiv eight wheat cultivar expos individu treatment ambient co temperatur ozon aco ao repres present climat scenario ii elev co ppm eco iii elev temperatur c et iv elev ambient ppb eo v elev co elev eco eo vi elev co elev temperatur elev eco eo et face facil simul futur climat chang scenario nich model predict reduct climat suitabl area wheat identifi maximum temperatur influenc factor area reduct elev co temperatur individu combin differenti impact yield wheat cultivar two cultivar viz dbw dbw exhibit yield declin suggest suitabl futur climat chang scenario sinc perform six eight cultivar signific declin simul face experi enm predict reduct wheat cultiv area rcp conclud futur wheat cultiv india bleak studi indic coupl bioclimat model face experi effect predict impact climat chang differ crop
|
D014908;D010126
|
T168;T103;T002
|
36,315,343
|
minim intervent dentistri mid mainstream unconvent option studi explor impact covid paediatr dentist view practic mid manag carious primari teeth children across unit kingdom european union explor techniqu use manag carious primari teeth covid pandem paediatr dentist dentist special interest paediatr dentistri dwsi member british societi paediatr dentistri bspd european academi paediatr dentistri eapd view use minim intervent dentistri mid children prior post covid era
|
D000086382;D057087;D003731
|
T061;T047;T033;T067
|
36,315,303
|
pim kinas promot tumor metastasi hepatoblastoma upregul cell surfac express chemokin receptor cxcr patient present metastat hepatoblastoma limit treatment option surviv rate low previous demonstr provir integr site maloney murin leukemia virus pim kinas promot tumorigenesi cancer cell stem hepatoblastoma studi assess role pim kinas promot hepatoblastoma metastasi util tail vein inject model metastasi evalu effect crisprca mediat pim knockout stabl overexpress pim pharmacolog pim inhibit format lung metastasi vivo studi reveal pim knockout impair format lung metastasi mice inject wild type hepatoblastoma cell develop lung metastasi none mice inject pim knockout hepatoblastoma cell develop lung metastasi pim overexpress hepatoblastoma increas pulmonari metastat burden mice mechanist upregul phosphoryl cell surfac express cxcr key receptor progress cancer cell metastasi cxcr blockad amd decreas metastat phenotyp pim overexpress cell indic cxcr contribut pim promot hepatoblastoma metastasi clinic pim express correl posit cxcr express primari hepatoblastoma tissu conclus shown pim kinas promot metastat phenotyp hepatoblastoma cell upregul cxcr cell surfac express find suggest target pim kinas may provid novel therapeut strategi metastat hepatoblastoma
|
D018197;D008113;D008175
|
T191
|
36,315,295
|
oncoprotein spike protein evalu intramolecular stabil use hydropath forc field evalu intramolecular stabil protein play key role comprehens biolog behavior mechan action small structur alter mutat induc singl nucleotid polymorph impact biolog activ pharmacolog modul covid mutat affect viral replic suscept antibodi neutral action antivir drug one exampl work intramolecular stabil mutat protein like spike glycoprotein complex human target evalu hydropath intramolecular energi score origin conceiv abraham kellogg base extens fragment method calcul amino acid zwitterion side chain partit coeffici abraham leo protein struct funct genet hint propos fast reliabl tool stabil evalu mutat system work written honor prof donald j abraham
|
D064370;D000086382
|
T123;T047;T116;T067
|
36,315,293
|
character novel temper phage staphylococcus aureus isol bovin milk bovin mastiti import diseas dairi cow staphylococcus aureus preval microorgan bacteriophag consid altern treat bacteri infect due antimicrobi resist crisi studi isol character novel aureus temper phage name bufsm bufsm bovin milk complet genom bufsm bufsm bp bp respect virus doubl strand dna linear architectur phylogen similar observ proteom staphylococcus phage phipv cn js therefor phage classifi famili siphovirida genus biseptimavirus order caudoviral host rang bufsm bufsm lytic activ respect inclus isol staphylococcus sciuri rothia terra thus studi speci novel aureus temper phage isol character phage reveal similar howev distinct speci aureus phage famili siphovirida
|
D013203;D008414;D017906
|
T047;T005
|
36,315,292
|
epidem model short live mix group almost epidem model make assumpt infect driven interact pair individu one infecti suscept howev societi individu mix group vari size vari time allow one infect close contact one suscept individu given point time paper studi effect mix group beyond pair transmiss infecti diseas sir suscept formula see text infect formula see text recov model branch process approxim initi stage epidem initi infect function central limit theorem trajectori number infect suscept time epidem mani initi infect also deriv central limit theorem final size epidem mani initi infect ii major outbreak trigger initi infect show given basic reproduct number formula see text distribut size mix group signific impact probabl final size major epidem outbreak moreov standard pair base homogen mix epidem model shown repres worst case scenario highest probabl largest final size major epidem
|
D058872;D003141
|
T047;T067
|
36,315,282
|
ectop express nac transcript factor hanac haloxylon ammodendron increas abiot stress resist tobacco hanac transcript activ locat nucleus may involv respons high temperatur high salt drought stress well phytohormon iaa aba treatment studi demonstr hanac increas toler transgen tobacco abiot stress involv regul rang downstream gene metabol pathway also indic potenti applic hanac plant toler gene nac transcript factor play key role plant growth develop plant respons biotic abiot stress howev biolog function nac transcript factor desert plant haloxylon ammodendron still poor understood studi nac transcript factor hanac isol clone typic desert plant h ammodendron possibl biolog function investig bioinformat analysi show hanac uniqu n termin nac structur domain nac transcript factor quantit real time fluoresc analysi show hanac abl particip respons simul drought high temperatur high salt phytohormon iaa aba treatment sensit simul high temperatur phytohormon aba treatment subcellular local analysi show gfp hanac fusion protein local nucleus tobacco epiderm cell transcript self activ assay show hanac transcript self activ activ truncat assay confirm transcript activ activ locat c terminus hanac gene express exogen wild type nicotiana benthamiana physiolog function hanac verifi simul drought abiot stress result indic transgen tobacco better resist abiot stress wild type b fuminata transcriptom analysi show hanac involv regul rang downstream resist gene wax biosynthesi metabol pathway result suggest hanac may stress resist role h ammodendron potenti applic plant molecular breed
|
D014026;D019663
|
T002
|
36,315,271
|
cd cell atlas main organ implic impact fibrosi cd cell believ progenitor may use treat cardiovascular diseas howev exact ident role cd cell physiolog patholog condit remain unclear
|
D042783;D058628
|
T025
|
36,315,252
|
water qualiti stress amirkalayeh wetland northern iran amirkalayeh wetland list wetland intern import ramsar convent expos sever water qualiti stress result increas dissolv ion nutrient concentr addit situ measur physicochem paramet electr conduct ph temperatur total number water sampl collect amirkalayeh wetland surround surfac groundwat resourc investig import factor increas trophic state decreas water qualiti wetland water sampl analyz major ion dissolv plant nutrient nitrat nitrit ammonium phosphat three time increas salin dramat rise nutrient level observ amirkalayeh wetland excess nutrient intak result hyper eutroph trophic status amirkalayeh wetland hydrolog hydrochem statist studi investig role varieti possibl water qualiti degrad factor show surfac subsurfac drainag agricultur return water amirkalayeh wetland major caus increas trophic level decreas water qualiti result work indic amirkalayeh wetland expos sever water qualiti stress threaten aquat life ecosystem wetland therefor prevent inflow surfac subsurfac agricultur drain wetland provid sustain water manag plan vital improv water qualiti wetland
|
D053833;D060753
|
T033;T083;T070
|
36,315,239
|
technic ethic legal societ challeng digit twin system manag chronic diseas children young peopl advanc digit medicin make possibl use digit twin system dts combin extens patient monitor use multipl sensor person adapt patient care use softwar artifici pancrea system alreadi oper children type diabet new dts could develop real time monitor manag children chronic diseas provid care children specif disciplin pediatr particular characterist need provid digit care children also present particular challeng articl review technic challeng main relat problem data collect children ethic challeng includ need preserv child place care use dts legal challeng dual need guarante safeti dts children ensur access dts societ challeng includ need maintain human contact trust child pediatrician limit dts specif use avoid contribut surveil societi anoth level climat chang
|
D035502;D003922
|
T047;T054
|
36,315,235
|
excess drink among men sex men recruit web base resourc cross section questionnair studi us northern european studi found higher preval alcohol relat problem among men sex men msm among general popul men gpm howev reli tradit sampl method profit msm date app websit recruit besid analog comparison southern europ lack
|
D000437;D063425;D000072339
|
T055;T098;T048
|
36,315,230
|
entomolog surveil invas aed speci higher prioriti entri point northern iran exploratori report field studi arbovir diseas dengu zika chikungunya transmit aed aegypti ae albopictus emerg global public health concern
|
D000330;D000071243;D000071244
|
T047;T005;T204
|
36,315,229
|
intervent includ smart technolog compar face face physic activ intervent older adult systemat review meta analysi systemat review random control trial meta analysi compar smart technolog face face physic activ pa intervent communiti dwell older adult mean age year
|
D011788;D015444
|
T078;T056;T061
|
36,315,228
|
valid chatbot use mental health assess experiment studi mental disord adolesc young adulthood major public health concern digit tool text base convers agent ie chatbot promis technolog facilit mental health assess howev human like interact style chatbot may induc potenti bias social desir respond sdr may requir effort complet assess
|
D008603;D000437
|
T041;T048
|
36,315,221
|
definit health app medic app perspect public health law qualit analysi interdisciplinari literatur overview term health app medic app often use interchang necessarili mean thing better understand term better regul technolog need distinct definit health medic app
|
D011634;D063731
|
T170;T091
|
36,315,218
|
global variat event base surveil diseas outbreak detect time seri analysi robust flexibl infecti diseas surveil crucial public health event base surveil eb develop allow time detect infecti diseas outbreak use most web base data despit widespread use eb evalu systemat global scale term outbreak detect perform
|
D007251
|
T047
|
36,315,214
|
ocular syphili syphili also known great imit abil mimic mani diseas due extens rang clinic manifest review aim provid updat clinic present diagnosi treatment ocular syphili manifest spectrum way occur stage diseas may present featur system syphili common find panuv diagnosi usual aid serolog test nonspecif treponem antibodi screen follow specif treponem antibodi confirm diagnosi treatment ocular syphili similar neurosyphili includ intraven aqueous crystallin penicillin
|
D013587;D015818
|
T047
|
36,315,213
|
optic nerv edema polysomnographi anoth way diagnos obstruct sleep apnea system diseas ophthalm manifest find examin fundus assist diagnosi treatment diseas manuscript present two ophthalm condit caus optic disc edema high associ obstruct sleep apnea osa condit non arterit anterior ischem optic neuropathi naion papilledema associ pickwickian syndrom condit suspect patient refer polysomnographi examin
|
D020181;D018917
|
T047
|
36,315,212
|
solv medic mysteri eye young patient budd chiari syndrom new vision loss budd chiari syndrom heterogen group disord character venous drainag obstruct liver extrem rare clinic manifest usual ascit varicos vein sever case hepat insuffici behcet diseas chronic idiopath inflammatori diseas manifest obstruct vascul affect varieti organ system ocular involv occur approxim patient major clinic criterion diagnosi rare behcet diseas caus budd chiari syndrom case diagnosi crucial impact treatment prognosi patient sinc patient budd chiari syndrom secondari behcet diseas usual improv system medic need surgeri addit patient higher chanc develop hepatocellular carcinoma need tight long follow
|
D006502;D001528;D014605
|
T047
|
36,315,211
|
ocular manifest behet diseas ocular involv behet diseas occur patient present organ intra ocular inflamm uveiti relat behet diseas main panuv includ occlus retin vascul recurr inflamm result develop ocular complic includ macular edema retin neovascular quarter eye develop vision loss diagnosi base clinic ophthalm find ocular imag includ retin fluorescein angiographi optic coher tomographi earli diagnosi treatment may prevent develop ocular complic vision loss treatment base primarili system corticosteroid nd line immunosuppress agent particular anti tumor necrosi factor agent extens treatment prevent relaps complic result long term stabl vision
|
D001528;D014605;D031300
|
T047
|
36,315,210
|
ocular sarcoidosi year old healthi femal past system ocular histori present decreas vision eye initi examin extens vitreal opac eye follow visit bilater panuv newli observ without otherwis system clinic manifest patient respond well treatment system topic steroid initi workup exclud tuberculosi syphili angiotensin convert enzym ace within normal rang order make definit diagnosi exclud lymphoma decid perform vitreous biopsi week steroid withdraw cessat steroid new lesion appear beneath right eye nasal bridg moreov iri nodul stroma pupil margin anterior chamber angl notic eye biopsi skin lesion demonstr non caseat granuloma support diagnosi sarcoidosi chest comput tomographi ct scan demonstr compat radiolog find bilater hilar mediastin lymphadenopathi sarcoidosi chronic multisystem autoimmun granulomat diseas ocular involv common among patient sarcoidosi common ocular manifest uveiti report case present bilater panuv due sarcoidosi system manifest elev serum biomark definit diagnosi verifi histopatholog find skin biopsi radiolog find chest ct
|
D012507;D014605;D015864
|
T047
|
36,315,209
|
optic disc edema mccune albright syndrom craniofaci polyostot fibrous dysplasia part mccune albright syndrom sever complic includ vision loss also patient syndrom greater risk secondari intra cranial pressur elev due medic side effect
|
D005359;D010211;D011629;D009901
|
T047;T191;T046
|
36,315,208
|
case seri earli neuroimag patient vascular risk factor isol six cranial nerv palsi demonstr dilemma earli imag various etiolog isol third fourth sixth cranial nerv palsi common etiolog adult age year older vascular risk factor diabet hyperlipidemia hyperlipidemia microvascular ischemia role earli neuroimag older patient vascular risk factor present acut isol ocular motor nerv palsi controversi
|
D020432;D015840;D003389;D020434
|
T047
|
36,315,207
|
idiopath intracrani hypertens patient ulcer coliti uveiti idiopath intracrani hypertens iih syndrom most affect young overweight women characterist caus headach transient visual obscur doubl vision tinnitus nausea vomit sever diseas may caus irrevers visual loss iih may primari may secondari various medic diseas herebi present case studi patient ulcer coliti uveiti present blur vision headach tinnitus diagnos iih discuss differenti diagnosi relat under diseas treatment
|
D011559;D014012;D003093;D014605
|
T184;T047;T037
|
36,315,206
|
bilater ocular plasmacytoma present acut anterior uveiti year old woman present ophthalmolog outpati clinic abrupt onset pain blur vision red right eye medic histori remark multipl myeloma success bone marrow transplant recurr diseas secondari plasma cell leukemia manag biolog agent examin reveal sever fibrin anterior uveiti accompani kerat precipit rubeosi iridi rais intra ocular pressur iop normal fundus patient treat intens topic steroid iop lower agent system acyclovir prednison respons partial develop posterior synechia iri bomb angl closur anterior segment ultrasound demonstr sever thicken iri appear bilater sub conjunctiv salmon patch eye facilit histopatholog diagnosi extraocular tissu biopsi reveal plasma cell infiltr suggest plasmacytoma ruthenium plaqu radiotherapi administ gy dose initi eye new cycl system chemotherapi complet regress treatment achiev bilater
|
D010954;D009101;D014606;D005901
|
T047;T191
|
36,315,205
|
optic neuriti classif manag treatment optic neuriti inflammatori condit optic nerv frequent first manifest central nervous system diseas typic optic neuriti strong associ multipl sclerosi etiolog atyp optic neuriti vari visual system prognosi well manag depend suspect etiolog understand classif atyp optic neuriti evolv signific sinc discoveri anti aquaporin aqp anti myelin oligodendrocyt glycoprotein mog antibodi biomark patholog caus neuromyel optica spectrum disord nmosd mog associ disord mogad respect addit caus optic neuriti includ multipl autoimmun infecti diseas one third optic neuriti case idiopath correct time diagnosi optic neuriti etiolog crucial proper treatment initi reduc long term visual system disabl
|
D009902;D009471
|
T047
|
36,315,204
|
acut vision loss associ hypereosinophil syndrom hypereosinophil syndrom hes rare disord eosinophil toxin damag capillari coronari endothelium neuron axon differ target organ patient experi stroke result endotheli dysfunct cardiomyopathi secondari embol hyperviscos hypercoagul treatment target lower eosinophil count shorten tissu surviv time support care anticoagul given requir report case myocard respiratori failur cortic blind due rapid deterior hes case demonstr earli recognit appropri treatment reduc tissu toxic function loss due hypereosinophil syndrom
|
D017681;D009205;D020521
|
T047;T191
|
36,315,203
|
ocular manifest system diseas uveiti neuro ophthalm manifest may indic under system andor neurolog condit systemat approach patient form comprehens anamnesi thorough ocular physic examin help reveal undiagnos condit evolv ill prompt diagnosi utmost import case potenti sight threaten life threaten natur condit subspecialti neuro ophthalmolog uveiti requir mani instanc multidisciplinari approach emphas special issu
|
D014605;D009462
|
T047;T091
|
36,315,187
|
simul studi effect natur occur point mutat sri dna complex molecular dynam md simul conduct order investig effect natur occur point mutat transcript factor tf sex determin region sri structur dynam sri dna complex normal sri along two mutant gr compris point mutat sri chain clinic identifi patient sex development disord model dna complex model work aim elucid atom level structur determin aberr sri dna complex mean long md result suggest observ disord brought gr dna dna may aris predomin destabil complex accord vitro assay found elsewher modif dna bend reveal studi compar potenti mean forc comput sequenc short separ distanc three complex verifi higher stabil normal sri dna examin way sri mutat modul sri dna complex dynam microscop level import also toward elucid molecular determin function protein capabl bind dna
|
D017354;D004268
|
T049;T116;T123
|
36,315,179
|
steer dna condens engin nanointerfac dna receiv increas attent nanotechnolog due abil fold prescrib structur differ common adopt base pair strategi emerg class amorph dna materi form dna abiolog interact despit great success lack nanoscal nucleationgrowth control disabl advanc consider work aim har heterogen nucleat metal ion glu dna condens nanointerfac upon unveil key orthogon factor includ solut ph ionic cross linker surfac function chemic programm dna condens nanoparticl seed achiev resembl famous stber process silica coat nucleat rule discov individu nanose pass dimer assembl broken spheric symmetri exist interparticl gap help regiospecif dna gelat steerabl dna condens multifunct dna metal ion nanocor hold great promis noncanon dna nanotechnolog toward novel applic
|
D036103;D053758
|
T090;T073
|
36,315,178
|
studi mrna wt baalc evi prame hmga gene whole blood sampl simultan quantit measur mrna wt baalc evi prame hmga gene whole blood sampl reflect specif patholog prolif activ acut leukemia ratio promis diagnost marker transcriptom profil acut leukemia cell usual assess use ngs microarray techniqu preliminari procedur isol mononuclear cell howev result use multiplex pcr reaction simultan determin mrnas whole blood sampl publish far determin mrna wt baalc evi prame hmga gene venous blood level sampl multiplex rt pcr studi includ blood sampl patient diagnosi acut leukemia subsequ confirm comparison group sampl patient without oncohematolog diagnosi select includ sampl k normal blood formula sampl k violat cellular composit anemia leukocytosi thrombocytopenia rna isol revers transcript perform use ribozol reverta l kit tsniie russia determin mrna express level wt baalc evi prame hmga gene multiplex real time pcr use homemad multiplex pcr kit mrna level character high interindividu variat correl rate circul leukocyt blood blast express wt mrna observ whole blood one patient control group patient leukemia combin decreas level hmga mrna express baalc mrna valu contrast control group patient leukemia higher level baalc mrna aml increas prame mrna aml apl lower level hmga apl
|
D015470;D013921
|
T047;T191
|
36,315,177
|
age chang foot microbiom estim microscopi method despit great number investig area tinea pedi question open extent dermatophyt fungi spread among modern popul occurr interrel host age investig group includ volunt year old skin scale collect heel area foot sign heel skin troubl express point contrast usual laboratori microscop magnif x work x allow estim fungal bacteri form averag abund microbi morphotyp express point heel skin troubl increas process age pirson coeffici r bacilli occur person independ age abund increas age contrari cocci common abund young person feet occurr dermatophyt increas age relat high valu took place young person mycelium spore group without heel skin troubl symptom allow refer fungi normal habitat foot skin
|
D008853;D064307
|
T001;T032;T059;T028
|
36,315,176
|
evalu structur human microbiom multipl sclerosi concentr microbi marker blood relationship multipl sclerosi state human microbiom studi name chang represent microbiota phylotyp proport coccal flora proport anaerob gram negat proteolyt activ microflora well concentr marker bacteri plasmalogen endotoxin blood microbiom studi carri gas chromatographi mass spectrometri microbi marker blood statist signific increas blood concentr total level microbi marker bacteri plasmalogen endotoxin determin multipl sclerosi may associ increas permeabl intestin wall multipl sclerosi proport coccal gram negat anaerob microflora proteolyt type metabol activ increas correl represent microbiota phylotyp chang due switch direct relationship proteobacteria bacteroid proteobacteria firmicut multipl sclerosi actinobacteria proteobacteria increas firmicut decreas conclus multipl sclerosi diseas may associ patholog chang structur microbiom growth endotoxemia may one factor pathogenesi diseas new laboratori marker diagnos predict cours ms propos
|
D009103;D064307
|
T001;T047;T032;T028
|
36,315,175
|
influenc lactam antibiot activ k pneumonia bacteria biofilm form isol wound patient chronic osteomyel one reason emerg high resist strain associ abil bacteria form biofilm various surfac format biofilm pathogen lead decreas activ antibiot increas time product stress respons gene bacteria result increas antimicrobi toler investig effect imipenem cefepim activ biofilm form k pneumonia bacteria isol wound patient chronic osteomyel object studi clinic strain k pneumonia isol wound patient chronic osteomyel control seri level biofilm format k pneumonia strain assess hour cultiv coverslip well polystyren plate second third seri biofilm form k pneumonia bacteria expos imipenem cefepim hour activ biofilm format assess accord previous develop criteria structur emerg biofilm surfac coverslip seri experi repres singl adher cell microcoloni various size cultiv antibiot led decreas number microcoloni rang size second third seri howev signific differ control seri found expos cefepim intens film format k pneumonia control seri tablet method unit optpl cultiv biofilm togeth antibacteri drug biofilm form activ hour experi signific lower control group experiment seri k pneumonia bacteria isol patient chronic osteomyel cultiv polystyren plate surfac coverslip activ form biofilm exhibit high adhes properti studi antibiot shown bacteriostat effect biofilm form k pneumonia bacteria bactericid effect imipenem cefepim biofilm form reveal
|
D011137;D010019
|
T047;T122;T109
|
36,315,174
|
analysi level optoped rehabilit studi microbiom evalu degre fixat remov plate prosthesi widespread use tradit remov prosthet explain relat simplic technolog stage manufactur determin avail develop prosthet stomat oral caviti facilit poor fixat stabil remov orthoped structur microbiom biofilm form surfac dental orthoped structur help reduc servic life caus inflammatori process oral caviti microbi etiolog dental prosthet process orthoped rehabilit purpos studi assess level adapt patient orthoped rehabilit base studi microbiom assess degre fixat remov lamellar dentur qualit quantit characterist microbiom prosthes stage orthoped pealit assess facult anaerob speci belong genera staphylococcus micrococcus enterococcus streptococcus klebsiella prevail note elimin microorgan genera bifidobacterium lactobacterium yeast like fungi speci candida albican isol analysi index fixat prosthes show increas depend durat use good level fixat prosthes establish group patient
|
D003832;D064307
|
T001;T032;T074;T028
|
36,315,173
|
laboratori diagnosi communiti acquir bloodstream infect therapeut patholog communiti acquir bloodstream infect cbsis occur hospit set increas overal mortal bloodstream infect bsis per year develop cbsis depend comorbid polymorbid diseas patient age caus cbsis respiratori hepatobiliari gastrointestin urogenit tract dental intervent etiolog cbsis character isol coagulas negat staphylococci cns e coli investig communiti acquir bloodstream infect therapeut patient studi includ hospit patient n ml blood taken intraven close vacuum system order obtain buffi coat blood put glass microscopi petri dish blood agar cultiv aerob anaerob condit microorgan identifi mass spectrometri microscopi blood smear use rapid diagnosi infect bloodstream bsi diagnos hospit patient etiolog cbsis studi isol strain microorgan cbsis rather often complic under diseas women young peopl spectrum cbsi pathogen includ aerob anaerob bacteria fungi gram posit cocci leadership sepidermidi often isol among bacteria isol pathogen grew anaerob condit cbsis character polymicrobi two four differ microorgan one blood cultur speci associ polymicrobi blood cultur shown microscop examin blood smear reveal microorgan case includ associ bacteria fungi cbsis occur contour plastic diseas respiratori system genitourinari system oral caviti skin subcutan tissu microbiolog examin buffi coat altern microbiolog method cbsis diagnosi includ microscopi blood cultiv high diagnost effici respect becom option replac import blood cultur autom system
|
D016470;D017714;D018805
|
T047;T046
|
36,315,172
|
assess system immun respons patient inflammatori complic larg joint implant one common reason progress asept instabl implant structur patient end stage osteoarthrosi disord immunogenulatori process bone tissu remodel along chronic inflammatori respons influenc endoprosthesi wear compon research featur specif system immun respons patient inflammatori complic late postop period total replac larg joint factor analysi enabl determin signific immunolog mechan associ progress implant asept instabl pathogenet signific compon involv format cellular humor immun respons patient sign inflammatori activ late postop period identifi find use design diagnost prognost criteria system inflammatori respons sever preoper monitor condit patient need larg joint arthroplasti also detect progress implant asept instabl
|
D011475;D010003
|
T047;T067
|
36,315,171
|
biochem profil benc jone type multipl myeloma multipl myeloma mm malign tumor occur plasma cell produc abnorm monoclon immunoglobulin paraprotein distinct featur benc jone myeloma excret monoclon free light chain immunoglobulin h urin absenc monoclon intact immunoglobulin secret comprehens analysi biochem paramet blood serum h urin patient benc jone multipl myeloma use electrophoret immunoturbidimetr method assess sensit biomark patient morpholog confirm diagnosi mm benc jone immunochem type examin peopl without oncolog diseas examineda control detect monoclon secret blood serum daili urin perform immunofix electrophoresi hydrasi electrophoret system sebia determin free light chain immunoglobulin flc perform immunoturbidimetr method bind site advia analyz siemen analysi igg iga igm microglobulin c reactiv protein perform coba analyz roch median excret benc jone protein h urin mm patient gh gh blood serum case presenc paraproteinemia repres type light chain immunogloublin detect time frequenc detect monoclon secret blood serum benc jone type myeloma statist signific higher frequenc detect monoclon secret type patient identifi paraproteinemia benc jone protein excret daili urin median gday statist signific higher patient without monoclon compon detect blood serum median gh level flc blood serum obtain immunoturbidimetri benc jone myeloma correspond type higher refer level case median level flc reach mgl flc mgl statist signific higher control level median concentr igg iga igm patient benc jone myeloma statist signific lower control group median microglobulin c reactiv protein signific higher control investig show high diagnost effici electrophoret immunoturbidimetr analysi monoclon secret patient benc jone mm flc analysi demonstr maximum sensit benc jone mm reveal biochem sign secondari immunodefici general inflammatori syndrom
|
D009101;D010265
|
T047;T191
|
36,315,170
|
character blood biomark prospect follow patient cardiovascular patholog combin type diabet mellitus covid associ pneumonia studi characterist dynam laboratori biomark patient cardiovascular diseas cvd type diabet mellitus underw covid associ pneumonia great clinic import prevent risk advers event studi use data patient present work patient divid group group includ patient cvd arteri hypertens ah combin coronari arteri diseas cad without dm n group includ patient cvd dm n patient examin baselin infecti diseas hospit month discharg laboratori examin blood biosampl evalu paramet general blood test biochem immunologicai paramet elast properti vascular wall analyz leukocyt paramet index coeffici increas nlr ratio neutrophilslymphocyt decreas lymcrp ratio lymphocytescrp signific chang dm group patient group signific excess baselin max crp concentr decreas paramet month persist excess valu group three month discharg patient dm level hs crp il tnfa nt probnp exceed refer valu group reflect presenc pronounc vascular inflammatori potenti possibl advers event group patient post covid period method multipl regress show dm independ risk factor increas stiff vascular wall thus dynam control laboratori paramet prognost valu assess natur cours covid associ pneumonia patient cvd dm develop algorithm person monitor patient post covid period aim time prevent unwant vascular complic
|
D003924;D000086382;D002318
|
T047;T067
|
36,315,159
|
trustworthi percept mandatori task instruct modul fast period visual stimul trustworthi respons although often assum human spontan respond trustworthi other face still unclear whether respons facial trust mandatori modul instruct consider scientif interest lie understand whether trust process mandatori given societ consequ bias trust behavior test whether neural respons index trustworthi discrimin depend whether task involv focus facial trustworthi use fast period visual stimul electroencephalographi oddbal paradigm neural marker trustworthi discrimin hz particip judg face size without refer trust explicit form impress facial trust given financi lend context prime trust without explicit trust judgement instruct signific trustworthi discrimin respons hz found three condit demonstr robust natur trustworthi discrimin neural level moreov effect task instruct observ bayesian analys provid moder decis evid task instruct affect trustworthi discrimin find visual trustworthi discrimin mandatori point remark spontan trustworthi process provid clue regard often unreli impress ubiquit
|
D035502;D007600
|
T041;T054
|
36,315,151
|
percept firearm access suicid among us adult live household firearm survey studi us adult live household firearm use counterfactu question assess whether respond believ restrict access firearm might prevent death suicid
|
D005389;D013405;D014948
|
T033;T073;T037
|
36,315,150
|
racial ethnic differ rate age diagnosi autism spectrum disord cohort studi use electron health record data assess racial ethnic dispar preval median age diagnosi autism spectrum disord children
|
D000067877
|
T048
|
36,315,149
|
symptom problem gambl among us adult wager sport survey studi assess level problem gambl risk across categori sport relat wager among us adult
|
D005715;D013177
|
T055;T056;T048
|
36,315,148
|
famili plan fertil career decis among femal oncologist femal oncologist often spend childbear year train establish career mani later experienc fertil issu start famili physician fertil famili plan rare discuss train attitud among femal oncologist regard famili plan unknown
|
D007396;D000072103;D007246
|
T065;T033;T046;T097
|
36,315,147
|
associ vagin progesteron treatment prevent recurr preterm birth preterm birth ptb lead caus infant morbid mortal worldwid suggest vagin progesteron vp treatment may reduc recurr ptb
|
D011374;D047928
|
T123;T121;T109;T125;T046
|
36,315,146
|
mental health morbid time cancer diagnosi among adult colon cancer england mental health morbid mhm patient present possibl cancer symptom may associ prediagnost care time cancer diagnosi
|
D008603;D003110
|
T191;T041
|
36,315,145
|
characterist medicaid polici children medic complex state qualit studi famili children medic complex cmc report barrier access afford coverag full rang servic children may need optim health outcom medicaid enrol medic need base elig mechan help cover servic gap understand state state variat cmc access medicaid may allow polici maker pediatrician help famili navig need servic cmc
|
D008484;D006297
|
T089;T033;T064;T080
|
36,315,144
|
preval factor associ high blood pressur among adolesc india high blood pressur bp children adolesc becom one common health condit worldwid much wide preval previous thought
|
D001786;D006973
|
T047;T109
|
36,315,143
|
effect high intens interv train patient atrial fibril random clinic trial patient atrial fibril af experi poor function capac qualiti life qol high intens interv train hiit shown elicit greater improv function capac qol compar moder vigor intens continu train mict cardiovascular popul yet hiit remain understudi af
|
D000072696;D001281;D000072038
|
T061;T056;T046;T047
|
36,315,142
|
associ matern caffein consumpt pregnanc child growth greater caffein consumpt pregnanc associ reduc birth size potenti associ childhood growth unclear
|
D002110;D009765
|
T121;T047;T109
|
36,315,141
|
social determin associ exposur childhood parent bereav subsequ risk psychiatr disord preval childhood parent death vari race ethnic socioeconom status yet whether similar variat persist associ lifetim psychiatr disord unknown
|
D001523;D001601;D063129
|
T051;T041;T048
|
36,315,123
|
bioinformat analysi experiment identif immun relat gene immun cell progress retinoblastoma retinoblastoma rb common type aggress intraocular malign children alter immun rb progress invas yet well defin studi investig signific alter immun associ gene cell relat rb invas
|
D019572;D012175
|
T191
|
36,315,120
|
deep learn base model dark adapt curv robust paramet estim studi investig deep learn dl sequenc model techniqu reliabl fit dark adapt da curv estim key paramet patient age relat macular degener amd improv robust curv predict
|
D000077321;D008268
|
T047;T066
|
36,315,102
|
lack efficaci fenbendazol giardia duodenali natur infect popul dog franc giardiosi worldwid intestin parasitosi affect human anim treatment dog remain limit lack efficaci approv medic rise concern studi dog rais veterinari student natur infect giardia duodenali treat home condit fenbendazol mgkg oral consecut day fecal sampl collect immedi treatment fs day treatment fs day treatment fs giardia duodenali cyst excret measur quantit direct immunofluoresc assay dfa fs fs fs molecular type nest pcr target ssu r dna locus also perform fs fs fecal consist improv dog mean cyst shed reduc treatment howev dog achiev therapeut success reduct cyst dog complet elimin g duodenali molecular type show dog harbor canin specif assemblag high preval assemblag c analyz sampl also detect differ assemblag treatment nucleotid substitut assemblag c sequenc describ previous eight ten day treatment high giardia cyst excret measur suggest possibl reinfect despit hygien measur andor multipl data suggest fenbendazol treatment may improv fecal consist limit therapeut efficaci giardiosi popul dog research still need assess efficaci fenbendazol canin giardiosi
|
D016829;D003458;D004283;D005873;D003560
|
T047;T190;T204
|
36,315,098
|
move delphi studi develop physic activ train programm prototyp co produc qualit research research develop co produc project call move social work purpos ongo project train social worker promot physic activ disabl peopl first stage project consist build evid design train programm prototyp part stage delphi studi conduct ask lead expert includ prototyp questionnair sent particip consensus reach reflect result peopl involv studi comment expert opinion percentag agreement co product partner resolv delphi insuffici call detail convers expert respons call follow interview expert particip final questionnair round delphi carri interview co produc dyadic data prompt dialog inquiri use frame co analys data result illumin capac qualit research justifi rectifi complic clarifi concret expand question consensus base evid implic result move social work discuss beyond empir border project wider contribut literatur present part two key statement highlight warrant dialog inquiri support practic co produc research delphi studi follow big q qualit studi
|
D015444
|
T061;T056
|
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