PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,668,077 | teratolog trilobit silurian wenlock ludlow australia document malform trilobit present invalu insight palaeobiolog wholli extinct euarthropod group although northern hemispher record relat well document exampl abnorm trilobit australia limit furthermor record specimen cambrian age rock extend limit record document five new exampl malform australian trilobit middl late silurian wenlock ludlow deposit yarralumla format australian capit territori yarwood siltston member black bog shale new south wale record first exampl abnorm pygidi thorac node present new evid bifurc pygidi rib abnorm featur consid teratolog morpholog aberr node like aros development malfunct bifurc rib repres either similar defect injuri develop teratolog featur explan limit record malform australian trilobit decreas injur trilobit end ordovician present document malform australian trilobit middl late paleozo undoubt paint complet pictur gondwanan taxa recov injuri unfortun development complic | D005580 | T167 |
34,668,075 | dispar telehealth use support care communiti respond telehealth use increas set covid pandem howev dispar telehealth use base age incom raceethn low health digit literaci limit english profici multilevel barrier telehealth use patient health system telehealth portal polici level ensur equiti telehealth servic leverag servic maxim reach health care servic concert effort need design telehealth tool workflow includ reimburs staff train patient educ technic support need telehealth use furthermor ongo monitor respons modif use telehealth servic need promot telehealth equiti | D000086382;D017216 | T058;T047;T067 |
34,668,074 | generat human papillomavirus hpv refer databas maxim genom map genom experi analyz human papillomavirus hpvs requir care select list sequenc refer databas map million read avail sourc papillomavirus epistem pave organ base variat l gene rather whole hpv sequenc moreov pave process use complex multipl sequenc align contain hundr thousand sequenc issu complic generat refer databas genom lead generat per analysi defin databas propos de novo strategi consid hpv sequenc report ncbi databas defin subset high repres hpv sequenc strategi base oligonucleotid frequenc profil whole sequenc follow hierarch cluster use data hpv captur experi demonstr strategi select suitabl sequenc refer databas map mappabl read unambigu provid recommend improv hpv map generat fasta file access https githubcomvtrevinohpv ref genom | D052685;D030361 | T047;T005 |
34,668,073 | symptom fluctuat menstrual cycl anxieti disord ptsd ocd systemat review anxieti disord preval sever women men extant research suggest menstrual cycl modul sever express anxieti symptom across rang disord aim systemat review synthesis exist literatur investig menstrual phase relat fluctuat symptom anxieti disord relat condit ptsd ocd menstruat women evalu methodolog use psycinfo pubm search april studi measur compar symptom diagnos anxieti disord ptsd ocd least two menstrual phase fourteen studi meet inclus criteria identifi review reveal evid exacerb broad rang symptom panic disord ptsd social anxieti disord generalis anxieti disord around week prior post mens onset coincid elev declin ovarian hormon low hormon level respect effect heterogen individu differ symptom type key methodolog weak includ sub optim inconsist mean defin identifi menstrual phase low sampl repres small sampl size menstrual fluctuat anxieti symptom appear featur anxieti disord ptsd ocd like occur subset women futur research field could better manag account heterogen use group base trajectori model larger sampl size use pre screen recruit women known histori menstrual fluctuat anxieti symptom | D009771;D013313 | T048 |
34,668,072 | birth locat infant prenat diagnos hypoplast left heart syndrom conflict data deliveri locat impact outcom neonat ductal depend heart diseas goal evalu impact deliveri locat hospit length stay surviv infant prenat diagnos hypoplast left heart syndrom hlhs stage palliat sp multicent cohort studi perform util nation pediatr cardiolog qualiti improv collabor dataset infant prenat diagnos hlhs underw sp august decemb univari comparison demograph clinic outcom data made multivari logist regress perform group stratifi distanc surgic center total patient center analyz born mile surgic center born surgic center infant born mile surgic center signific p like male white full term non cardiac anomali commerci health insur signific like breastfe pre oper less like pre oper cardiac catheter pre oper mechan ventil delay surgeri signific differ group hospit length stay day surviv surviv hospit discharg multicent dataset hospit length stay surviv sp differ base distanc birth locat surgic center howev neonat born mile surgic center lower rate potenti modifi pre oper risk factor includ mechan ventil delay surgeri | D018636;D058327 | T047;T061 |
34,668,071 | first experi spectrum compact ce system newli releas spectrum compact ce system promega capillari electrophoresi instrument develop dna fragment separ sequenc studi compat commerci short tandem repeat str kit differ manufactur reproduc size precis accuraci concord robust sensit mixtur resolut test compar abi prism genet analyz instrument abl success analys amplicon test kit prove precis claim manufactur specif shown robust abi prism genet analyz aspect analys spectrum compact ce system abl resolv peak length differ basepair short long fragment rang mixtur mixtur ratio describ advantag limit observ far work instrument forens genet laboratori | D016172;D018895 | T034;T114;T063;T123 |
34,668,070 | case report fatal bleed duoden ulcer dieulafoy lesion year old man admit hospit ambul due syncop standard blood screen show normal hb valu man known hemorrhoid singl fresh rectal bleed earlier home follow morn patient sudden requir resuscit within minut subsequ die autopsi reveal fatal hemorrhag blood loss stomach small larg intestin mucos defect duodenum autopsi question aros whether caus death might rare dieulafoy lesion aim case report clarifi diagnosi | D004381 | T047 |
34,668,068 | laparoscop guid distal loco region anesthet infiltr techniqu tapp inguin hernia repair doubl blind random clinic trial ultrasound guid transversus abdomini plane block us tap import compon multimod analgesia laparoscop inguin hernia repair although certain limit overcom surgeon develop sever techniqu perform local anesthet infiltr laparoscop guidanc trial evalu transabdomin preperiton tapp hernia repair conduct till date aim studi compar efficaci novel laparoscop guid local anesthet infiltr techniqu ldai us tap postop pain control analges consumpt patient undergo elect tapp hernia repair | D006552;D010535 | T190;T061;T047;T060 |
34,668,067 | singl incis laparoscop percutan extraperiton closur silpec inguin hernia prolaps ovari studi report outcom laparoscop ovarian prolaps hernia oper larg sampl size base intracorpor closur studi extraperiton closur limit sampl size proactiv use singl incis laparoscop percutan extraperiton closur silpec techniqu obtain favor outcom report paper | D006552;D010535 | T190;T061;T047;T060 |
34,668,066 | attend guidanc advis educ qualiti surgic video youtub youtub use platform case prepar surgic traine despit popular use studi note limit surgic techniqu safeti vet video studi identifi view laparoscop cholecystectomi lc video youtub analyz abil attend resid medic student identifi critic portion procedur techniqu limit video | D017081;D010535;D061108 | T170;T060;T061 |
34,668,065 | topic applic otosporin offic bleach split mouth tripl blind multicent random clinic trial evalu topic applic otosporin offic bleach hydrogen peroxid hp gel reduc risk intens tooth sensit ts well bleach effect | D003807;D014073;D058205 | T167;T047;T061 |
34,668,064 | anticoagul patient acut kidney injuri undergo kidney replac therapi kidney replac therapi krt use provid support therapi critic ill patient sever acut kidney injuri various non renal indic modal krt includ continu krt ckrt intermitt hemodialysi hd sustain low effici daili dialysi sled howev circuit clot major complic investig extens extracorpor circuit clot caus reduct solut clearanc caus blood loss lead upsurg treatment cost rise workload intens educ review discuss pathophysiolog clot cascad within extracorpor circuit use various type anticoagul method various pediatr krt modal | D058186;D000079664 | T061;T047;T037 |
34,668,055 | type diabet risk determin second generat migrant mix ethnic peopl south asian african caribbean descent uk excess risk type diabet uk south asian sa african caribbean ac compar european remain unexplain studi risk determin type diabet first second generat born uk migrant mix ethnic | D003924;D014171 | T047;T098 |
34,668,054 | surviv hypothermia torpor wild live rat rare insight broaden understand endotherm physiolog maintain high stabl bodi temperatur observ endotherm mammal bird energet cost thus surpris discov heterotherm speci reduc energet need energet bottleneck use torpor howev heterotherm anim use torpor regular basi torpor may also import individu probabl surviv henc fit use infrequ report observ singl h long hypotherm bout decreas bodi temperatur c nativ australian bush rat rattus fuscip data suggest bush rat abl rewarm bodi temperatur c albeit rewarm rate lower expect basi bodi mass heterothermi ie abil withstand overcom period reduc bodi temperatur assum evolutionarili ancestr plesiomorph trait thus argu rare hypotherm event speci otherwis appear strict homeotherm could heterotherm rudiment ie less deriv form torpor limit capac rewarm import observ rare extrem thermoregulatori respons wild anim like discov long term data set may provid valuabl insight physiolog capabl popul also help us understand constraint evolutionari pathway differ phenolog | D007035;D064348 | T033;T037 |
34,668,053 | photosynthesi pigment product elucid interact effect nutrient light chlamydomona reinhardtii chlamydomona reinhardtii produc varieti compound benefici human anim health among compound applic photosynthet pigment chlorophyl carotenoid gain consider interest numer industri better understand interact effect essenti nutrient light microalg physiolog pigment product would benefici improv cultiv strategi therefor studi evalu biomass carotenoid chlorophyl yield follow fluoresc paramet quantum yield ps ii ii electron transport rate etr use respons surfac methodolog rsm f v f npq also monitor howev signific relationship observ investig appar nitrogen carbon well interact effect nitrogen carbon carbon light irradi signific factor model predict optimum condit maximum carotenoid mg g mol l nitrogen mol l mol photon light irradi maximum chlorophyl mg g requir higher nitrogen mol l photosynthet paramet ii etr correl primari pigment biomass product increas photosynthet activ associ high carbon light ii etr psii condit respect approach accur develop model optim factor analys interact effect studi serv provid better understand interact factor influenc pigment biosynthesi photosynthet perform chlamydomona reinhardtii | D008027;D010788;D010860 | T044;T070;T039;T120 |
34,668,052 | social implement remot surgeri system japan field experi use newli develop surgic robot via commerci network recent year expect telesurgeri grown develop robot assist surgic technolog advanc communic technolog verifi feasibl social implement telesurgeri evalu communic integr avail communic delay robot surgeri remot control differ communic condit commerci line | D065287;D012371;D017216 | T090;T058;T061 |
34,668,051 | map input nois escap nois integr fire neuron level cross approach nois spike neuron common model noisi input current generat output spike stochast voltag depend hazard rate escap nois input nois lend model biophys nois process phenomenolog escap nois mathemat tractabl use level cross theori differenti gaussian process deriv approxim map color input nois escap nois leaki integr fire neuron map requir first passag time fpt densiti overdamp brownian particl driven color nois respect arbitrarili move boundari start wiener rice seri fpt densiti appli second order decoupl approxim stratonovich case move boundari deriv simplifi hazard rate represent local time numer effici simplif requir calcul non stationari auto correl function level cross process exponenti correl input nois ornstein uhlenbeck process obtain exact formula zero lag auto correl function nois paramet mean membran potenti speed well exponenti approxim full auto correl function theori well predict fpt interspik interv densiti well popul activ obtain simul color input nois time depend stimulus boundari agreement simul strong enhanc across sub suprathreshold fire regim compar first order decoupl approxim neglect correl level cross second order approxim also improv upon previous propos theori subthreshold regim depend simplic accuraci trade consid approxim repres use map color input nois escap nois enabl progress theori neuron popul dynam | D008959;D009474 | T025;T170 |
34,668,050 | comparison two differ surgic procedur treatment isol spinal metastasi patient metastat spinal cord compress case control studi aim studi compar total en bloc spondylectomi tes separ surgeri postop stereotact radiosurgeri ssrs isol metastat patient spinal cord compress assess recurr free surviv rfs overal surviv os postop complic qualiti life score qol | D013117;D013125 | T191;T047 |
34,668,049 | congenit hyperinsulin local focal lesion f fdopa positron emiss tomographi hyperinsulinem hypoglycemia infanc also known congenit hyperinsulin group disord character dysregul insulin releas neonat sever persist hyperinsulinem hypoglycemia unrespons medic therapi requir pancreatectomi prevent brain damag hypoglycemia date multipl genet mutat syndrom sever uniqu histopatholog entiti identifi children hyperinsulin histopatholog character diffus focal atyp surgic resect focal lesion result cure children imag fluoro f l dihydroxyphenylalanin f fdopa positron emiss tomographi pet test choic identifi local focal lesion prove invalu guid surgic resect genet evalu essenti determin benefit pet imag articl provid approach determin imag set protocol interpret imag find diagnosi manag disord requir multidisciplinari approach prevent brain damag hypoglycemia | D044903 | T047 |
34,668,048 | util novel scale assess readi discharg bariatr surgeri safe releas patient hospit care bariatr surgeri depend upon achiev satisfactori health status describ new object scale readi discharg rfd scale measur patient suitabl hospit discharg bariatr surgeri | D050110;D010535;D009767 | T047;T060;T061 |
34,668,047 | supervis immedi postop mobil elect colorect surgeri feasibl studi earli mobil signific part era societi guidelin patient recommend spend h bed day surgeri howev yet known earli patient safe mobil complet colorect surgeri aim studi evalu feasibl safeti provid almost immedi structur supervis mobil start min post surgeri postop anesthesia care unit pacu describ reaction approach | D003107;D013505 | T091;T061 |
34,668,046 | prognost factor lymph node metastasi pattern primari duoden cancer effect extent region lymph node dissect primari duoden cancer dc remain unclear studi aim analyz prognost factor lymph node metastasi lnm pattern dc | D004379 | T191 |
34,668,042 | paper thread media frugal detect urinari tract infect uti urinari tract infect uti make signific proport global burden diseas vulner group tend substanti impair qualiti life affect make time detect uti prioriti public health howev econom societ barrier drastic reduc access tradit lab base test method critic patient group low resourc area negat affect overal healthcar outcom result cellulos base materi paper thread garner signific interest among research substrat call frugal analyt devic leverag materi portabl adapt facil reproduc diagnos uti although field may infanc strategi aim commerci penetr appreci increas access healthcar option risk peopl review catalogu recent advanc devic use cellulos base materi primari hous medium uti detect chart trend field also explor differ modal employ detect particular emphasi abil port onto discreet case sanitari product | D010209 | T073 |
34,668,040 | multiphas cta deriv tissu map aid detect medium vessel occlus medium vessel occlus mevo challeng detect imag multiphas comput tomographi angiographi mcta shown improv larg vessel occlus lvo detect endovascular treatment evt select aim studi determin mcta deriv tissu map accur detect mevo predict infarct h follow imag compar accuraci ct perfus ctp | D002545;D020521 | T047;T046 |
34,668,039 | cd cell found within endem burkitt lymphoma modul burkitt lymphoma precursor cell viabil express pathogen relev epstein barr virus gene endem burkitt lymphoma ebl aggress b cell cancer character ighc myc transloc harbor epstein barr virus ebv evid accumul cd cell might contribut ebl pathogenesi investig presenc cd cell primari ebl tissu potenti dichotom impact ebv infect pre ebl cell model use ex vivo materi vitro co cultur addit establish novel method studi effect ighc myc transloc primari b cell employ crisprca knock approach introduc tag de novo transloc unpreced document cd cell present primari ebl tumor tissu furthermor demonstr cd cell one hand suppress ebl develop kill pre ebl cell lack ighc myc transloc vitro hand indirect promot ebl develop induc crucial ebv latenc iii latenc switch pre ebl cell final show mere presenc ighc myc transloc suffic escap cd cell mediat kill vitro cd cell mediat suppress ebv latenc iii program vivo may allow cell harbor ighc myc transloc addit mutat evad immun control prolifer mean deregul c myc activ result neoplasia thus studi highlight dichotom effect cd cell mechan involv ebl pathogenesi suggest mechan impact ebl progress provid novel vitro model investig ighc myc transloc | D002051;D020031 | T191;T047 |
34,668,031 | correl type iiia crispr cas system sccmec staphylococcus epidermidi subcultur sepidermidi strain atcc amen genet manipul occasion found laboratori mutant exhibit suscept methicillin contrast parent strain unveil under mechan whole genom sequenc mutant perform compar analysi reveal larg dna fragment encompass crispr cas system type r system sccmec element delet mutant larg chromosom delet associ crispr cas system also observ occur spontan epidermidi anoth independ laboratori artifici induc introduc engin crrnas bacteri speci find impli crispr cas system affect bacteri genom remodel delet integr mges mobil genet element bioinformat analysi identifi higher carriag rate sccmec element epidermidi strain harbor crispr cas system mlst type phylogenet analysi cripsr cas posit epidermidi strain reveal multipl origin addit distinct type sccmec carri strain suggest acquisit mge origin multipl independ recombin event intrigu crispr cas system found alway locat vicin orfx gene among staphylococci allel analysi crispr loci flank cas gene disclos loci distal orfx gene consider stabl conserv probabl serv recombin hotspot crispr cas system phage plasmid therefor find general support notion incomplet immun protect crispr cas system promot dissemin neighbor sccmec element | D013203;D013212 | T007;T047 |
34,668,030 | fortif grain food nova potenti alter nutrient intak avoid ultra process food nova food classif system describ hierarchi minim process ultra process food upf research associ intak upf chronic diseas australia primari sourc grain refin whole bread breakfast cereal typic fortifi classifi upf yet recommend core food accord australian dietari guidelin adg research aim identifi avoid ultra process grain food would alter nutrient intak australian popul whether sampl diet use substitut non upf food would like meet nutrient requir | D002523;D057140 | T168 |
34,668,029 | enhanc bone remodel fractur prime immun system activ compon bone repair mast cell influenc recruit macrophag osteoclast blood vessel repair tissu hypothes mast cell immun cell sensit recogn broken bone mount increas respons subsequ fractur may translat enhanc heal test creat bone defect left leg anesthet mice week later second one right leg bone repair right leg compar control mice underw creation bilater window bone defect time mice euthan day miner tissu quantiti morphometr paramet assess use micro ct histolog activ osteoblast osteoclast vascular endotheli cell mast cell macrophag evalu use histochemistri main find signific differ amount bone produc day post oper group mice expos subsequ fractur show signific better bone morphometr paramet day post oper signific increas content blood vessel osteoclast number macrophag subsequ fractur group result provid strong evid transient increas inflammatori state heal injuri promot faster bone remodel increas neo angiogenesi phenomenon also character chang mast cell macrophag content translat activ recruit mesenchym stromal cell | D042783;D050723 | T025;T037 |
34,668,028 | clinic predict high turnov bone diseas kidney transplant bone histomorphometr analysi accur method evalu bone turnov non invas tool also requir studi whether bone biomark predict high bone turnov determin bone histomorphometri kidney transplant retrospect evalu result bone biopsi specimen obtain kidney transplant recipi due clinic suspicion high bone turnov bone biomark acquir concurr kidney transplant recipi biopsi taken median interquartil rang month engraft patient includ statist analysi present high bone turnov normal low bone turnov detect patient discrimin high bone turnov non high alkalin phosphatas parathyroid hormon ioniz calcium area receiv oper characterist curv auc respect combin marker perform better auc posit predict valu high turnov predict probabl cutoff negat predict valu studi concur previous observ hyperparathyroid without hypercalcemia necessarili impli high bone turnov kidney transplant recipi predict high bone turnov improv consid alkalin phosphatas level present logist regress model bone biopsi readili avail model may serv clinic avail tool recogn high turnov engraft | D001847;D012080;D016030 | T047;T061 |
34,668,027 | geograph distinct longev indic correl climat factor area chines yao distribut longev research hot topic health field consider research focus longev phenomenon bama yao autonom counti typic karst landform locat southwest china studi aim illustr spatial featur longev indic yao area analyz correl climat factor longev indic provid new clue target longev studi collect integr popul climat terrain data spatial databas main analysi method includ spatial autocorrel highlow cluster multiscal geograph weight regress mgwr two longev cluster identifi guijiang river basin longev index li liujiang river basin li spatial distribut longev indic autocorrel moran p cluster signific z score p mgwr show atmospher pressur signific affect spatial distribut li estim valu ev p centenar index ci ev p uc ev p ch ev p rainfal signific affect spatial distribut li ev p ci ev p spatial distribut main longev indic show signific heterogen autocorrel cluster guijiang river liujiang river basin atmospher pressur rainfal may contribut longev phenomenon complex mechan longev phenomenon yao nation guijiang river basin requir studi improv understand health effect meteorolog environment social condit longev | D008136;D045483 | T070;T079;T102 |
34,668,026 | rest state function connect structur abnorm brain acut retard catatonia exploratori mri studi first cross section mri studi acut catatonia compar rest state whole brain within network seed left precentr gyrus voxel connect well cortic surfac complex sampl patient acut retard cataton state n diagnos per dsm criteria demograph match healthi control sampl n patient comorbid axi psychiatr disord includ schizophrenia spectrum disord psychot mood disord diagnos neurolog disord acut retard catatonia character reduc rest state function connect robust within sensorimotor network diffus region interest roi roi hyperconnect seed voxel hyperconnect frontopariet cerebellar region seed left precentr gyrus voxel connect posit correl catatonia motor rate roi roi well seed voxel function hyperconnect note higher lorazepam respond n comparison non respond n overal hedg g effect size analys rang indic robust result averag dice coeffici jackknif reliabl analys rang indic fair inter region roi roi connect perfect within sensorimotor network connect reliabl result catatonia sampl show reduc vertex wise cortic complex right insular cortex contigu area thus identifi neuroimag marker acut retard cataton state may show associ treatment respons benzodiazepin discuss novel find import translat implic understand pathophysiolog catatonia well mechanist understand predict treatment respons benzodiazepin | D002389 | T048;T047 |
34,668,024 | particul drug induc toxic assess novel quadrupl cell human primari hepat diseas model steatosi pre fibrot nash effort replac reduc refin anim experiment unmet need advanc current vitro model offer featur physiolog relev enhanc predict vivo toxicolog output hepat toxicolog key follow chemic drug nanomateri nms exposur liver vital metabol detoxif chemic well major site xenobiot accumul ie low solubl particul ever increas product nms necess evalu probabl consequenti advers effect health also clinic asymptomat liver part risk stratif strategi studi two uniqu diseas initi mainten protocol develop utilis mimic steatosi pre fibrot nash scaffold free liver microtissu mt compos primari human hepatocyt hepat stellat cell kupffer cell sinusoid endotheli cell character diseas mt util toxicolog assess panel xenobiot highlight studi includ clear experiment evid pre exist liver diseas import augment xenobiot induc hepatotox nms abl activ stellat cell data demonstr pre exist diseas vital intensif xenobiot induc liver damag therefor imper stage wide spectrum liver diseas incorpor risk assess strategi signific consequ substanti number general popul suffer sub clinic liver injuri without appar diagnos manifest | D065626 | T047 |
34,668,023 | function variant rpskb pikr autophagi pathway gene risk bladder cancer autophagi play critic role cancer sinc either suppress tumorigenesi inhibit cancer cell surviv facilit tumorigenesi promot cancer cell prolifer tumor growth howev role genet variant autophagi regul key gene bladder cancer risk remain unclear aim explor associ bladder cancer genet variant gene involv autophagi pathway gene base analysi perform multi marker analysi genom annot magma bladder cancer case control logist regress model use calcul snp effect bladder cancer suscept express quantit trait loci eqtl analysi conduct genotyp tissu express gtex project gene express evalu base cancer genom atlas tcga databas three potenti function snps rpskb rs pikr rs rs demonstr associ risk bladder cancer ci p rs ci p rs ci p rs increas number risk genotyp three snps associ higher risk develop bladder cancer besid rs exhibit eqtl effect rpskb whole blood p furthermor higher express rpskb lower express pikr signific associ bladder cancer risk find indic genet variant autophagi pathway gene rpskb pikr confer bladder cancer suscept | D001749 | T191 |
34,668,021 | phlebotomus neglectus diptera psychodida new insight presenc iran base three independ genet loci idea exist phlebotomus larroussius neglectus diptera psychodida tonnoir iran skeptic exist phlebotomus major sstr annandal grown recent countri studi report combin analysi mitochondri ribosom dna target region p major slannandal specimen collect differ part iran two differ morphotyp found among collect sampl base shape aedeagus ventral locat hair coxit paramer sheet one morphotyp seem similar p neglectus tonnoir p major krimensi perfiliv call mink one similar p neglectus extent p notus artemiev neronov call miinno cytochrom b elong factor alpha intern transcrib spacer ii loci amplifi sequenc character high sequenc homolog observ p neglectus morphotyp phylogenet analysi also concord phlebotomus neglectus sequenc avail genbank locat sister group sequenc particular near morphotyp miinno moreov locus provid maximum resolut differenti two morphotyp base achiev result although strong support presenc p neglectus provid earli say p major sstr doesdo exist iran question could resolv studi sampl import compar topotyp p neglectus p major str possibl futur | D010691 | T204 |
34,668,019 | bodi mass index subfertil multivari regress mendelian random analys norwegian mother father child cohort studi associ bmi subfertil | D007246;D057182 | T033;T062;T046 |
34,668,018 | novel conceptu approach lean valu psycholog condit engag work perceiv organiz support hospit care lean think lt emerg promis approach reduc wast improv effici howev applic effect within healthcar particular within hospit base care remain cloud uncertainti paper attempt answer question lean think best appli hospit base care | D003695;D006761 | T058;T093;T073 |
34,668,014 | effici communiti face cover surgic mask limit spread aerosol current pandem context covid peopl wear differ type mask particular workplac limit spread virus depend activ work environ employe requir wear communiti face cover cloth mask transpar window surgic mask reusabl mask respir object studi evalu effici sourc control mask ie worn protect environ spread particl emit wearer experiment test bench includ dummi head breath simul associ deh droplet generat emit particl exhal stream use sourc control effici calcul total flux particl emit test section without mask seventeen model mask test three breath rate condit studi rest heavi breath averag rate lmin sourc control effici vari one mask anoth among communiti face cover seven model valu rang medium intens breath effici surgic mask three model rang breath cycl communiti face cover dispos surgic mask present equival valu sourc control effici respect respir show higher sourc control effici type mask statist analysi data show effect breath flow rate interact effect mask type particl size differ sourc control found two particl size differ experiment breath rate respir surgic mask communiti face cover cloth mask transpar window present sourc control effici increas particl size vari level effici measur higher sourc control respir type mask context respiratori protect programm provid effect barrier spread virus result show also mask stop particl emit wearer regardless type mask barrier measur ventil social distanc hygien necessari | D000086382;D016273 | T047;T037;T067 |
34,668,013 | pathway link parent health literaci health behaviour direct child scope review health literaci hl thought crucial manag manifold demand relat child health parent face albeit mani studi investig parent hl health behaviour hbs direct child knowledg pathway link parent hl hb scarc aim scope review identifi comprehens describ varieti pathway link parent hl hbs direct child empir analys previous studi follow establish scope review method databas search conduct medlin embas psycinfo webofsci march elig criteria includ primari empir studi assess parent hl hb direct child general parent popul titl abstract screen independ six review potenti relev public data extract use standard data extract form search identifi articl titl abstract screen full text review studi includ review studi n assum direct associ hl hbs studi n use complex model investig differ pathway mediat andor moder model overal evid under pathway link parent hl hbs direct child mix fair limit therefor hypothesi driven research integr result theoret framework need advanc research hl public health practic | D057220 | T041 |
34,668,012 | mental health without well mental healthi ongo movement promot mental health reduc stigma establish pariti mental physic health clear enthusiasm concept recognit valu human life howev often unclear mental health mean effort whether singl concept under sometim initi sake mental health aim reduc mental ill thus implicit identifi mental health absenc diagnos psychiatr diseas ambiti high profil propos adopt posit definit identifi mental health psychic even overal well argu definit mental health mere absenc mental ill thin undemand close link psychiatr valu judgment definit term well demand potenti oppress compromis sketch middl posit view mental health primari good psycholog precondit pursu concept good life includ well without ident well | D001523;D008603 | T048;T041 |
34,668,011 | medicalis childbirth access homebirth uk covid beyond articl explor law perpetu medicalis childbirth outlin may limit abil birth person access opt homebirth argu inher problemat restrict choic autonomi childbirth suggest widespread blanket withdraw homebirth servic nation health servic trust coronavirus covid pandem serv illustr exampl broader failur recognis social legal signific homebirth argu frame correct law potenti support rather restrict choic regard place birth | D000086382;D008880 | T097;T091;T047;T067 |
34,668,009 | osteoprotegerin regul vascular function syndecan nadph oxidas deriv reactiv oxygen speci osteogen factor osteoprotegerin opg protect vascular calcif howev opg also posit associ cardiovascular damag particular pulmonari hypertens possibl process beyond effect calcif present studi focus calcif independ vascular effect opg activ syndecan nadph oxidas nox isol resist arteri wistar kyoto wki rat expos exogen opg studi myographi exhibit endotheli smooth muscl dysfunct opg decreas nitric oxid product eno activ increas reactiv oxygen speci ros product endotheli cell vsmcs opg increas ros product hoperoxynitrit level activ rho kinas myosin light chain opg vascular redox effect also inhibit syndecan inhibitor synstatin ssnt addit heparinas chondroitinas abolish opg effect vsmcs ros product confirm syndecan opg molecular partner suggest opg bind heparanchondroitin sulphat chain syndecan opg induc ros product abrog noxad nox inhibitor gkt dual noxnox inhibitor tempol sod mimet inhibit vascular dysfunct induc opg addit studi arteri nox nox knockout ko mice nox nox ko abrog opg induc vascular dysfunct vascular dysfunct elicit opg mediat complex signal cascad involv syndecan nox nox data identifi novel molecular mechan beyond calcif opg may underli vascular injuri effect osteogen factor condit hypertens andor diabet | D018384 | T049 |
34,668,007 | aminoglycosid resist gene signatur predict aminoglycosid mic carbapenem resist klebsiella pneumonia aminoglycosid contain regimen may effect treatment option infect caus carbapenem resist klebsiella pneumonia cr kp aminoglycosid resist gene common strain relationship aminoglycosid resist gene aminoglycosid mic remain poor defin | D000617;D007711 | T007;T121;T109 |
34,668,005 | multipl phenyl ring append base complex strong visibl light absorpt dna bind seri facial co base acycl complex possess bis chelat ligand triphenylphosphin oxid donor synthes character interest structur featur complex coordin ligand function extern phenyl ring singl crystal x ray diffract analysi confirm molecul demonstr varieti intermolecular supramolecular interact via extern phenyl ring complex display strong absorpt cm wide visibl region nm due interest structur photophys properti complex satisfactori dna bind abil observ bind complex dna groov confirm signific increas absorpt intens complex visibl region absorpt enhanc dna circular dichroism | D056831 | T104 |
34,668,003 | probiot companilactobacillus crustorum mn allevi coliti associ tumorigenesi via modul intestin microenviron supplement probiot promis method allevi colorect cancer crc via modul intestin microenviron studi aim assess potenti anti crc effect companilactobacillus crustorum mn azoxymethan dextran sulfat sodium induc coliti associ ca crc mous model mice gavag c crustorum mn daili cfu per mous ca crc amelior effect strain investig base gut microbiota inflamm intestin barrier integr result show c crustorum mn could signific attenu tumorigenesi inflamm via suppress tlrnf b pathway moreov probiot could improv intestin barrier integr increas mrna level tight junction relat protein reduc goblet cell loss addit c crustorum mn administr led increas benefici bacteria decreas harm bacteria therebi increas scfas reduc lps level result suggest c crustorum mn could partial amelior format ca crc modul gut microbiota attenu inflamm enhanc intestin barrier integr therefor c crustorum mn promis probiot supplement attenu ca crc | D007778 | T007 |
34,668,002 | fluoresc electrochem detect iodin vapor presenc high humid use ln base mof effici detect toxic radioiodin speci emit nuclear relat activ accid crucial health human bodi safeti environ herein report seri stabl ln base mof btc linker ln btcs could provid dual fluoresc electrochem respons iodin vapor presenc humid iodin molecul could attract oxygen site carboxyl linker confin caviti ln btcs due photoinduc electron transfer effect fluoresc ln btcs quench drastic presenc iodin meanwhil conduct ln btcs could reach increas fold magnitud iodin trap water molecul could also trap ln btcs interact framework via hydrogen bond reduc iodin uptak capac alter fluoresc conduct properti ln btcs distinct iodin molecul could besid raman map suggest diffus coeffici iodin transport porous eu btc dual fluoresc electrochem signal output show high sensit attract abil reduc fals posit could use potenti integr sens radioiodin vapor | D006813 | T070 |
34,668,000 | intellig tumor microenviron respons nanotheranost agent dual modal magnet reson imag guid self augment phototherm therapi phototherm therapi ptt promis antineoplast therapeut strategi har restrain tumor growth near infrar nir irradi mediat thermal ablat nevertheless biolog applic hamper thermal diffus regul heat shock protein hsps herein versatil nanotheranost agent develop via integr zn fe nanoparticl nps polydopamin pda mno nps dual modal magnet reson mr imag guid self augment ptt design zn fe pda mno nps adequ serv ptt agent realiz effect phototherm convers obtain local hyperthermia addit zn fe pda mno nps signific consum overexpress glutathion gsh generat mn tumor microenviron tme thus destroy redox homeostasi catalyt generat hydroxyl radic oh hsp suppress ptt enhanc meanwhil mn zn fe nps signific strengthen weight mr contrast tumor imag ptt guidanc henc studi offer proof concept self augment ptt dual modal mr imag tumor elimin | D006979;D053758 | T073;T061 |
34,667,998 | nanowir base sensor electron chemic biolog applic detect recognit chemic biolog speci via sensor electron import various sens applic also fundament scientif understand past two decad sensor devic use one dimension nanowir emerg promis power platform electr detect chemic speci biolog relev molecul due superior sens perform long term stabil ultra low power consumpt paper present comprehens overview recent progress achiev nanowir synthesi work principl nanowir base sensor applic nanowir base sensor electron chemic biolog analyt detect recognit addit critic issu hinder practic applic nanowir base sensor electron includ devic reproduc select stabil power consumpt highlight final challeng perspect opportun develop advanc innov nanowir base sensor electron chemic biolog applic featur | D053770 | T073 |
34,667,330 | local neuropath pain local neuropath pain lnp peripher origin character circumscrib area pain abnorm skin sensit spontan symptom characterist neuropath pain eg burn pain note lnp confin specif area larger letter size sheet paper lnp account neuropath pain syndrom singl etiolog lnp diagnost approach similar neuropath pain condit general diagnost tool use assess clinic featur far specif guidelin manag lnp reason guidelin general neuropath pain use topic treatment includ part second line strategi canadian pain societi guidelin despit lack guidelin lidocain patch capsaicin patch proven effect lnp model | D009437 | T047;T184 |
34,667,329 | estim number prevent covid death relat restrict measur adopt america america unit state particular affect covid pandem | D000085762 | T054 |
34,667,328 | ramn de la fuent muiz builder modern psychiatri mexico latin america centenari birth mark centenari dr ramn de la fuent muiz birth promin member univers creator institut brief communic without pretend biographi tri commemor event judici object account outstand aspect life work | D011570 | T097;T091 |
34,667,327 | pros con innov medic educ medic educ implement various innov strategi purpos attain better learn achiev evalu made experi compet approach new learn technolog curricular altern profession evalu distanc educ technolog order locat area belong | D020375;D004501 | T065 |
34,667,326 | use pulmonari ultrasound predict hospit mortal patient covid infect lung ultrasound lus implement patient covid help establish degre pulmonari involv evalu treatment respons estim hospit outcom | D017052;D007362;D014463 | T080;T060;T093;T073 |
34,667,324 | imperi need telemedicin care diabet covid pandem comprehens approach studi patient diabet experi difficulti maintain glycem control confin due covid pandem risk develop diabet chronic complic sever covid | D000086382 | T047;T067 |
34,667,323 | reflect around ethic human intellig artifici intellig internet artifici intellig grown becom program code algorithm learn reprogram carri pre establish task greater effici although translat improv scope result reprogram unknown programm given risk deviat pre establish object ethic regul filter must instal begin end process alarm detect deviat bioethic implic interact human intellig artifici intellig negat posit disagr initi adapt regul labor law human right enough necessari ethic standard establish formul barcelona declar proper develop usag artifici intellig europ | D001185;D007360 | T041;T066;T073;T090 |
34,667,320 | impact covid morbid mortal accord regul use face mask current face mask repres incompar symbol whose valu went clinic work impact contain spread sar cov although becom element discord general popul | D006291 | T089 |
34,667,319 | covid epidemiolog mexican tertiari care hospit result covid mani hospit underw convers care diseas | D017052 | T080 |
34,667,318 | mental health mexican popul covid pandem covid pandem also affect mental health | D008603;D055500 | T041;T055 |
34,667,317 | social determin health associ sever mortal patient covid histor pandem result higher mortal rate vulner popul social determin health sdh associ peopl morbid mortal differ level | D064890 | T033;T067 |
34,667,316 | analysi qualiti anticoagul vitamin k antagonist three clinic scenario mexico vitamin k antagonist vka therapeut altern patient venous thromboembol diseas howev numer factor affect pharmacolog | D000925;D014812 | T121;T109;T127 |
34,667,315 | incid clinic characterist thyroid abnorm cancer patient treat immun checkpoint inhibitor immun checkpoint inhibitor ici group drug use recent year treatment advanc malign melanoma non small cell lung cancer tumor signific increas surviv howev use ici associ increas risk autoimmun diseas endocrin organ specif thyroid high suscept phenomenon | D002289;D008175;D013966 | T191;T047 |
34,667,314 | estim number prevent covid death relat restrict measur adopt europ decemb new coronavirus emerg wuhan china becom global health problem | D000085762 | T054 |
34,667,311 | toward predict model prevent risk covid infect scarciti person center applic aim develop awar risk pose covid pandem stimul explor creation prevent tool access popul | D015233 | T170;T081 |
34,667,309 | new exposur metric cumul effect short term exposur peak traffic relat ultrafin particl advers health outcom traffic relat ultrafin particl ufp disproport impact near highway neighborhood current studi focus either short term health outcom associ short term ufp exposur averag day week long term outcom associ long term year longer averag ufp exposur hypothes frequent repeat exposur short term ufp peak last hour could overwhelm alter physiolog defens respons result long term health issu herein propos new exposur metric measur cumul effect peak exposur | D000393;D052638 | T167;T131 |
34,667,308 | global effort dissect human genet basi resist sar cov infect sar cov infect display tremend interindividu variabl rang asymptomat infect life threaten diseas inborn error autoantibodi direct type interferon ifn account critic covid case among sar cov infect individu contrast genet immunolog determin resist infect per se remain unknown follow discoveri autosom recess defici darc chemokin receptor confer resist plasmodium vivax autosom recess defici chemokin receptor ccr enzym fut shown underli resist hiv norovirus respect along line propos strategi identifi recruit genet analyz individu natur resist sar cov infect | D020022 | T032 |
34,667,307 | immunolog asymptomat sar cov infect key question import challeng covid pandem understand asymptomat diseas extent may sourc transmiss asymptomat diseas definit hard screen lack clariti aspect covid spectrum studi consid whether preval asymptomat diseas determin differ age demograph viral load durat shed magnitud durabl immun clear adapt immun strong activ asymptomat infect featur cell antibodi respons may differ symptomat diseas area need greater clariti includ extent asymptomat diseas lead persist symptom long covid qualiti quantiti durabl immun prime requir confer subsequ protect | D058345;D007156 | T047;T042 |
34,667,306 | genom wide rate spectrum em induc herit mutat microcrustacean daphnia prospect forward genet forward genet screen use alkyl mutagen ethyl methanesulfon em effect method identifi phenotyp mutant interest genet dissect pinpoint causal genet mutat accur estim rate em induc herit mutat fundament determin mutant sampl size screen experi aim satur gene genom mutat studi examin genom wide em induc herit base substitut three speci freshwat microcrustacean daphnia help guid screen experi result show mm em treatment induc base substitut averag rate sitegener across three speci wherea signific higher averag mutat rate occur mm mutat spectrum em induc base substitut concentr domin g c transit furthermor find femal daphnia expos em f individu asexu produc uniqu mutant offspr f least consecut brood suggest multipl brood f mutant last estim f need gene daphnia genom mutat least probabl also recommend f collect f mutant sibl cross induc mutat could appear homozyg state f popul probabl | D003621;D009153 | T131;T204 |
34,667,302 | emot predict error guid social adapt behaviour peopl make decis base deviat expect outcom known predict error past work focus reward predict error larg ignor violat expect emot experi emot predict error leverag method measur real time fluctuat emot peopl decid punish forgiv other across four studi n reveal emot reward predict error distinguish contribut choic emot predict error exert strongest impact decis make addit find choic punish forgiv decod less second evolv emot respons suggest emot swift influenc choic final individu report signific level depress exhibit select impair use emot reward predict error evid emot predict error potent guid social behaviour challeng standard decis make model focus sole reward | D004644;D061347;D012201;D012917 | T054;T041;T078 |
34,667,294 | mismatch negat index target engag excitationinhibit base treatment develop doubl blind placebo control random singl dose cross studi serotonin type receptor antagonist cvn serotonin type receptor ht r antagonist show potenti treatment cognit deficit schizophrenia cvn brain penetr potent select ht r antagonist show efficaci rodent model cognit well toler phase studi evalu target engag cvn use mismatch negat mmn random doubl blind placebo control cross studi subject stabl outpati schizophrenia schizoaffect disord treat antipsychot subject permit use ht r modul serotonin reuptak inhibitor subject receiv high mg low mg mg oral dose cvn placebo random order across singl day treatment visit separ least week primari pre regist outcom amplitud durat mmn amplitud mmn deviant frequenc intens frequenc modul locat p p auditori steadi state respons assr exploratori endpoint random subject complet studi baselin panss score indic moder impair cvn mg led signific improv vs placebo primari outcom durat mmn p cohen signific treatment effect also seen combin analysi across mmn deviant p effect locat mmn independ signific p signific effect seen deviant dose eeg measur clinic signific treatment relat advers effect result show mmn sensit target engag biomark ht r support potenti util cvn correct excitatoryinhibitori imbal schizophrenia | D014150;D012559 | T039;T121;T048 |
34,667,293 | discoveri novel dpre inhibitor via comput bioactiv fingerprint structur base virtual screen decaprenylphosphoryl ribos oxidas dpre play import role biosynthesi mycobacterium cell wall dpre inhibitor shown great potenti develop new regimen tuberculosi tb treatment studi integr molecular model strategi combin comput bioactiv fingerprint structur base virtual screen employ identifi potenti dpre inhibitor two lead compound b h could inhibit dpre thus kill mycobacterium smegmati vitro identifi moreov compound h show potent inhibitori activ mycobacterium tuberculosi vitro mic mtb low cytotox mous embryo fibroblast nih cell research provid effect strategi discov novel anti tb lead compound | D000995;D009169 | T007;T121 |
34,667,283 | renal microvascular endotheli cell respons sepsi induc acut kidney injuri microvascular endotheli cell kidney neglect cell type sepsi induc acut kidney injuri sepsi aki research yet offer tremend potenti pharmacolog target endotheli cell distinct cortic microvascular segment high heterogen review focus endotheli cell anatom nich anim model sepsi aki reduc glomerular blood flow attribut inhibit endotheli nitric oxid synthas activ arteriol glomeruli wherea decreas cortex peritubular capillari perfus associ epitheli redox stress elev system level vascular endotheli growth factor reduc level circul sphingosin phosphat loss compon glycocalyx glomerular endotheli cell lead increas microvascular permeabl although coagul disbal occur microvascular segment molecul involv differ segment induct express adhes molecul leukocyt recruit also occur heterogen manner evid similar endotheli cell respons found kidney blood sampl patient sepsi comprehens studi need investig relationship segment specif chang microvasculatur kidney function loss sepsi aki applic omic technolog kidney tissu anim patient key identifi relationship develop novel therapeut sepsi | D058186;D018805 | T047;T037;T046 |
34,667,280 | physiolog role cell heterogen pancreat islet function endocrin cell within pancreat islet langerhan heterogen term transcript profil protein express regul hormon releas even though heterogen long appreci within past year detail molecular analys led improv understand basi although begin recogn subpopul endocrin cell phenotyp differ other arguabl import consider heterogen affect regul hormon releas control homeostasi glucos energi rich nutrient focus review descript endocrin cell heterogen princip insulin secret cell affect regul hormon secret within islet langerhan discuss includ overview function characterist differ islet cell subpopul describ communic influenc islet function basal glucos stimul condit discuss chang specif islet cell subpopul number might underli islet dysfunct type diabet mellitus conclud discuss sever key open question regard physiolog role islet cell heterogen | D003924;D050417;D007515 | T025;T023;T047 |
34,667,279 | role cellular senesc cardiac diseas basic biolog clinic relev cellular senesc classic defin stabl cell cycl arrest implic biolog process embryogenesi wound heal age senesc cell complex senesc associ secretori phenotyp sasp involv rang pro inflammatori factor import paracrin autocrin effect cell tissu biolog clinic evid experiment studi link cellular senesc senesc cell accumul product releas sasp compon age relat cardiac patholog heart failur myocardi ischaemia infarct cancer chemotherapi relat cardiotox howev precis role senesc cell condit unclear instanc detriment benefici effect report involv cellular senesc import entiti cardiac arrhythmia remodel poor understood review summar basic biolog cellular senesc discuss known role cellular senesc sasp heart diseas consid various approach develop prevent accumul senesc cell consequ mani strategi applic vivo investig non cardiac indic clinic trial end consid import knowledg gap direct futur research potenti implic improv manag patient heart diseas | D016922;D006331 | T043;T047 |
34,667,276 | androgen receptor lncrnasat akt p axi mediat androgen induc cellular senesc prostat cancer cell bipolar androgen therapi bat treat prostat cancer pca includ cycl supraphysiolog androgen level sal androgen depriv therapi adt show previous sal induc cellular senesc androgen sensit pca cell ex vivo treat patient pca tumor sampl analyz under molecular pathway reveal sal induc cellular senesc castrat sensit cspc lncap castrat resist pca crpc c cell cell cycl inhibitor p inkb increas phosphoryl akt treatment akt inhibitor akti potent inhibit sal induc express p inkb cellular senesc cell line proxim ligat assay pla combin high resolut laser scan microscopi indic sal promot interact endogen androgen receptor ar akt cytoplasm well nucleus detect three day transcriptom sequenc rna seq compar sal induc transcriptom lncap c cell well akti treat cell transcriptom reveal landscap cell senesc interest one identifi gene lncrnasat sal treatment nativ patient tumor sampl ex vivo upregul lncrnasat pca tumor tissu lncrnasat downregul compar nontumor tissu patient knockdown indic lncrnasat crucial sal induc cancer cell senesc upstream factor pakt p inkb knockdown lncrnasat enhanc cell prolifer sal suggest lncrnasat serv tumor suppressor sal interest immunoprecipit ar detect lncrnasat ar interact partner regul ar target gene express similar rna chip experi reveal interact ar lncrnasat chromatin thus identifi novel ar lncrnasat akt p inkb signal axi mediat sal induc cellular senesc | D000728 | T039;T121;T125 |
34,667,275 | calcineurin inactiv inhibit pyruv dehydrogenas complex activ induc warburg effect calcineurin calcium calmodulin depend serinethreonin protein phosphatas connect ca depend signal multipl cellular respons calcineurin inhibitor cnis wide use suppress immun respons allograft patient howev cnis signific increas cancer incid transplant recipi compar general popul accumul evid suggest cnis may promot malign transform cancer cell addit role immunosuppress under mechan remain poor understood show calcineurin interact pyruv dehydrogenas complex pdc mitochondri gatekeep enzym connect two key metabol pathway cell glycolysi tricarboxyl acid cycl mitochondri local calcineurin dephosphoryl pdha ser ser ser thus enhanc pdc enzymat activ remodel cellular glycolysi oxid phosphoryl suppress cancer cell prolifer hypoxia attenu mitochondri transloc calcineurin promot pdc inactiv moreov cnis promot metabol remodel warburg effect block calcineurin mediat pdc activ cancer cell find indic calcineurin critic regul mitochondri metabol suggest cnis may promot tumorigenesi inhibit calcineurin pdc pathway | D006019;D010085;D054730 | T044;T116;T082;T123 |
34,667,271 | cognit impair candid allogen hematopoiet stem cell transplant hematopoiet cell transplant hct increas common curat treatment strategi improv surviv among individu malign nonmalign diseas one million hcts perform worldwid neurocognit dysfunct common untoward consequ hct mani recipi although studi examin profil neurocognit impair hct associ clinic featur frailti incid pre hct neurocognit impair across age may influenc post hct neurocognit impair examin pattern correl pre transplant neurocognit dysfunct prospect sampl adult undergo hct neurocognit assess use montreal cognit assess batteri frailti assess use short physic perform batteri linear regress analysi use examin associ neurocognit perform frailti neurocognit screen profil also examin partit moca domain score includ execut function memori also examin associ neurocognit frailti clinic outcom includ length transplant hospit surviv one hundr ten adult evalu across wide age rang rang mean age sd neurocognit perform tend fall publish normat level mean moca sd particip demonstr impair perform compar medic normat data moca exhibit impair perform relat healthi sampl moca mild impair moca common across age rang includ middl age patient age age age particular item assess execut function greater level frailti associ lower neurocognit screen score r p execut function r p wherea greater age associ poorer memori perform r p greater level frailti prior transplant associ longer length stay p associ surviv neurocognit impair common among adult undergo hct pattern perform vari age pre transplant frailti associ neurocognit function may portend wors post transplant earli clinic outcom | D060825;D000073496;D018380 | T184;T046;T048;T061;T033 |
34,667,264 | smoc smoc regul bone format downstream molecul runx runx essenti transcript factor bone format although osteocalcin osteopontin bone sialoprotein well known runx regul bone specif gene skelet phenotyp knockout ko mice gene margin compar runx ko mice inconsist suggest unknown runx regul gene play import role bone format address attempt identifi runx target perform rna sequenc found smoc smoc upregul runx smoc smoc knockdown inhibit osteoblastogenesi smoc ko mice display fibula format smoc ko mice mild craniofaci phenotyp surpris smoc smoc doubl ko dko mice manifest skull shorten tibia fibula endochondr bone format also impair late stage dko mice collect result suggest smoc smoc function novel target runx play import role intramembran endochondr bone format | D018507 | T045 |
34,667,261 | effect mglur posit alloster modul frontostriat work memori activ schizophrenia negat symptom cognit deficit contribut strong disabl schizophrenia resist exist medic recent drug develop target enhanc nmda function increas mglur signal howev clinic util agent remain uncertain marker brain circuit function critic clarifi mechan understand individu differ efficaci conduct doubl blind placebo control random cross day washout pilot studi evalu adjunct use mglur posit alloster modul azd mg daili day chronic stabl patient schizophrenia n analyz focus fmri respons frontostriat region n back work memori task test hypothesi azd produc fmri chang correl improv negat symptom cognit found azd produc signific group averag effect symptom cognit accuraci howev azd increas n back fmri activ striatum p anterior cingulateparacingul p greater drug versus placebo effect caudat activ signific correl greater reduct panss negat symptom score r p exploratori correl suggest broader effect across multipl symptom domain region interest find demonstr fmri respons mglur posit modul relat individu differ symptom reduct could pursu futur biomark develop negat clinic result group level lead prematur termin investig mechan may benefit import subset individu schizophrenia imag biomark may reveal therapeut mechan help guid treatment toward specif popul | D014150;D018094;D012559 | T116;T121;T039;T192;T048 |
34,667,259 | assess exist adult neurogenesi human valu rodent model neuropsychiatr diseas sub mammalian vertebr like fish amphibian reptil new neuron produc entir lifespan capac diminish consider bird even mammal persist olfactori system hippocamp dentat gyrus adult neurogenesi declin even drastic nonhuman primat recent evid show basic extinct human seem use capac diminish primat evolut propos occur need retain acquir complex knowledg stabl popul neuron synapt connect mani decad human life review assess critic claim signific adult neurogenesi human show current evid strong indic human lack trait addit discuss alleg mani rodent studi adult neurogenesi involv psychiatr diseas potenti mechan human neuron replac regener argu report usual neglect signific structur function speci specif differ mislead general popul believ might cure varieti neuropsychiatr diseas well stroke brain trauma genesi new neuron incorpor exist synapt circuitri | D011323;D012377 | T015 |
34,667,255 | drug repurpos improv diseas target fold augment network modul target appli covid analysi present systemat evalu extent therapeut opportun obtain drug repurpos connect drug target diseas gene use fda approv indic refer level found drug repurpos offer averag fold increas diseas coverag maximum number diseas cover per drug increas extend drug target high confid first neighbor addit network analysi connect drug diseas modul found drug averag target diseas modul yet similar diseas modul target drug general low maximum number diseas modul target per drug increas drug target neighbor extend moreov result highlight drug repurpos depend target protein share diseas polypharmacolog properti drug appli drug repurpos network modul analysi covid show fostamatinib drug highest modul coverag | D000086402 | T005 |
34,667,244 | fibrinolyt nanocag dissolv clot tumor microenviron improv distribut therapeut efficaci anticanc drug fibrin one compon extracellular matrix ecm act transport barrier within core tumor constrict blood vessel form clot lead poor intratumor distribut anticanc drug group previous develop microplasmin base thrombolyt ferritin nanocag effici target dissolv clot without caus system fibrinolysi disrupt hemostat clot hypothes thrombolyt nanocag mediat degrad fibrin clot tumor ecm lead enhanc intratumor drug deliveri especi nanos anticanc drug fibrin clot deposit worsen surgeri chemotherapi hinder drug deliveri moreov risk venous thromboembol vte also increas use thrombolyt nanocag multival clot target peptid fibrin degrad enzym microplasmin dissolv fibrin tumor microenviron name fibrinolyt nanocag fncs fncs target tumor clot specif effect fncs effici dissolv fibrin clot insid tumor vessel suggest mitig risk vte cancer patient coadministr fnc doxorubicin led improv chemotherapeut activ syngen mous melanoma model furthermor fncs increas distribut doxildoxorubicin nanoparticl within mous tumor result suggest fibrinolyt cotherapi might help improv therapeut efficaci anticanc nanomedicin thus microplasmin base fibrinolyt nanocag promis candid strategi due hemostat safeti abil home tumor | D000970;D013927 | T046;T121;T109 |
34,667,241 | identif serum prognost biomark sever covid use quantit proteom approach covid pandem unpreced threat human provok global health concern sinc etiopathogenesi ill fulli character prognost factor enabl treatment decis well document accur predict progress diseas would aid appropri patient categor thus help determin best treatment option introduc proteom approach util data independ acquisit mass spectrometri dia ms identifi serum protein close associ covid prognosi twenti seven protein differenti express sever ill covid patient advers favor prognosi ingenu pathway analysi reveal protein might regul cytokin signal relev interleukin il il tumor necrosi factor tnf differenti express implic system inflammatori respons cardiovascular disord evalu practic predictor clinic prognosi sever covid patient subsequ elisa assay reveal chil igfal may serv high sensit prognost marker find help formul diagnost approach accur identifi covid patient sever diseas provid appropri treatment base predict prognosi | D020869 | T059;T063 |
34,667,192 | faecal mirna profil associ age sex bmi lifestyl habit healthi individu stabil detect faecal microrna repres promis molecul potenti clinic interest non invas diagnost prognost biomark howev evid stool mirna profil chang accord individu age sex bodi mass index bmi lifestyl habit influenc express level molecul explor relationship stool mirna level common trait sex age bmi menopaus status lifestyl habit physic activ smoke status coffe alcohol consumpt deriv self report questionnair use small rna sequenc data sampl healthi subject detect differenti express mirna associ one variabl associ least two differ mir level associ age sex bmi smoke status highest number differenti express mirna associ bmi n smoke status n sever mirna share function enrich analys reveal involv mirna target gene pathway coher analys variabl find suggest mirna profil stool may reflect common trait lifestyl habit consid relat diseas associ studi base faecal mirna express | D008019 | T047;T054 |
34,667,177 | phf regul neuron gene express pol ii ctd reader domain spoc c termin domain ctd largest subunit rna polymeras ii pol ii regulatori hub transcript rna process identifi phd finger protein phf regul transcript mrna stabil dock onto pol ii ctd spoc domain character spoc ctd reader domain preferenti bind two phosphoryl serin mark adjac ctd repeat phf drive liquid liquid phase separ phosphoryl pol ii coloc pol ii cluster track pol ii across length gene phf knock spoc delet human cell result increas pol ii stall reduc elong rate increas mrna stabil mark derepress neuron gene key neuron gene aberr express phf knock mous embryon stem cell result impair neuron differenti data suggest phf act promin effector neuron gene regul bridg transcript mrna decay | D012313 | T114 |
34,667,173 | mcas arabidopsi ca permeabl mechanosensit channel inher sensit membran tension mechanosensit ms ion channel respond mechan stress convert intracellular electr ionic signal five ms channel famili identifi plant includ mid complement activ mca channel howev activ mechan elucid detail herein demonstr mca channel ca permeabl ms channel direct activ membran tension n termin residu mca mca synthes vitro purifi reconstitut artifici liposom membran liposom reconstitut mca mca mediat ca influx applic pressur membran reconstitut mca elicit channel current channel also activ voltag blocker ms channel inhibit activ stretch voltag sinc mca protein found exclus plant result suggest mca repres plant specif ms channel open direct membran tension | D040542 | T044 |
34,667,163 | brd inhibit promot puma depend apoptosi augment effect imatinib gastrointestin stromal tumor gastrointestin stromal tumor gist primarili character activ mutat tyrosin kinas platelet deriv growth factor receptor alpha although revolutionari therapeut outcom imatinib well known long term benefit imatinib still unclear effect brd recent identifi subunit noncanon baf complex ncbaf chromatin remodel complex gist clear current studi evalu function role brd gist progress find demonstr express brd upregul gist tissu downregul inhibit brd could signific reduc cellular prolifer facilit apoptosi gist brd inhibit could promot puma depend apoptosi gist enhanc imatinib activ vitro vivo brd inhibit synerg imatinib gist induc puma upregul mechan studi reveal brd inhibit promot puma induct via tuftaktgsk p axi furthermor imatinib also upregul puma target aktgsk p axi conclus result indic brd play key role progress gist inhibit brd novel therapeut strategi gist treat alon combin imatinib | D017209 | T043;T116;T123 |
34,667,161 | loss numb promot hepat progenitor expans intrahepat cholangiocarcinoma enhanc notch signal numb stem cell fate determin act tumor suppressor close relat wide varieti malign intrahepat cholangiocarcinoma icca origin hepat progenitor hpcs howev role numb hpc malign transform icca develop still unclear retrospect cohort studi indic numb frequent decreas tumor tissu suggest poor prognosi icca patient consist chemic induc icca mous model numb downregul tumor cell compar normal cholangiocyt diet induc chronic liver injuri mous model numb ablat signific promot histolog impair hpc expans tumorigenesi similar numb silenc cultur icca cell enhanc cell spheroid growth invas metastasi express stem cell marker mechanist numb found bind notch intracellular domain nicd numb ablat promot notch signal effect revers notch signal block secretas inhibitor treatment result suggest loss numb play import role promot hpc expans hpc malign transform ultim icca develop chronic injur liver therapi target suppress numb promis treatment icca | D015398 | T043;T044 |
34,667,160 | erp form feedback regul loop microrna p promot progress colorect cancer express endoplasm reticulum er stress associ gene often dysregul cancer progress er protein erp abnorm express mani neoplasm play import role tumorigenesi show erp novel target microrna p mir p inhibit progress colorect cancer crc correspond erp act oncoprotein crc promot prolifer metastasi crc cell suppress apoptosi cell import found mir p express revers upregul erp suppress il elicit methyl mir p promot region process enterocyt maintain balanc mir p erp dysregul crc studi reveal novel feedback regul loop mir p erp critic maintain appropri level partial imbalanc crc result abnorm express mir p erp acceler crc progress provid support evid erp mir p potenti biomark diagnosi treatment crc | D018450;D025461 | T033;T046;T067 |
34,667,157 | signal pathway regul cytokin releas syndrom human diseas intervent therapi cytokin releas syndrom crs embodi mixtur clinic manifest includ elev circul cytokin level acut system inflammatori symptom secondari organ dysfunct first describ context acut graft versus host diseas allogen hematopoiet stem cell transplant later observ pandem influenza sar cov covid immunotherapi tumor chimer antigen receptor car therapi monogen disord autoimmun diseas particular sever crs signific life threaten complic clinic character persist high fever hyperinflamm sever organ dysfunct howev crs doubl edg sword may help control tumorsvirusesinfect harm host although high incid high level cytokin featur crs detail kinet specif mechan crs human diseas intervent therapi remain unclear present review summar recent advanc relat clinic featur manag crs well cut edg technolog elucid mechan crs consid crs major advers event human diseas intervent therapi review delin characterist kinet signal pathway potenti mechan crs show clinic relev achiev favor efficaci low toxic | D000080424 | T047 |
34,667,156 | phosphoglycer kinas silenc novel microrna microrna protect human osteoblast dexamethason activ nrf signal cascad nuclear factor e relat factor nrf cascad activ amelior dexamethason dex induc oxid injuri death human osteoblast phosphoglycer kinas pgk deplet shown effici activ nrf signal induc methylglyox modif kelch like ech associ protein keap identifi novel pgk target microrna microrna mir rna fluoresc situ hybrid rna pull argonaut rna immunoprecipit result confirm direct bind mir pgk mrna primari human osteoblast hfob osteoblast cell forc overexpress mir use lentivir construct robust decreas pgk utr untransl region luciferas activ downregul express human osteoblast hfob cell furthermor mir overexpress activ nrf signal cascad caus keap nrf disassoci nrf protein stabil nuclear transloc well transcript activ nrf depend gene nqo gclc ho human osteoblast express utr null pgk construct mir overexpress induc nrf cascad activ howev larg inhibit import dex induc reactiv oxygen speci product oxid injuri cell apoptosi signific attenu mir overexpress human osteoblast hfob cell action mir abolish nrf shrna knockout mimick pgk knockout use crisprca method pgk knockout human osteoblast mir overexpress fail increas nrf cascad activ offer osteoblast cytoprotect dex signific mir downregul human necrot femor head tissu dex take patient togeth pgk silenc mir protect human osteoblast dex activ nrf signal cascad | D019610;D020868;D015398 | T043;T044;T039;T045 |
34,667,151 | mutat hotspot determin high repeat evolut built broken silent genet chang mutat hotspot determin evolutionari outcom make evolut repeat hotspot product multipl evolutionari forc includ mutat rate heterogen variabl often hard identifi work reveal near determinist genet hotspot built broken hand silent mutat observ studi homolog immotil variant bacteria pseudomona fluorescen ar pf x ar resurrect motil high repeat de novo mutat nucleotid line minim media ntrb ac pf x howev evolv via number mutat mean two strain diverg signific adapt determin evolutionari dispar owe synonym variat within ntrb locus demonstr swap site observ abl break build determinist mutat hotspot work reveal key role silent genet variat determin adapt outcom | D019143;D000069456 | T038;T045 |
34,667,150 | spdef suppress head neck squamous cell carcinoma progress transcript activ nra sam point domain contain e transform specif transcript factor spdef play dual role initi develop human malign howev biolog role spdef head neck squamous cell carcinoma hnscc remain unclear studi express level spdef correl clinic paramet patient hnscc determin use tcga hnsc gse clinic cohort cck coloni format cell cycl analysi xenograft tumor growth model use determin molecular function spdef hnscc chip qpcr dual luciferas report assay rescu experi conduct explor potenti molecular mechan spdef hnscc compar normal epitheli tissu spdef signific downregul hnscc tissu patient hnscc low spdef mrna level exhibit poor clinic outcom restor spdef inhibit hnscc cell viabil coloni format induc gg cell cycl arrest silenc spdef promot cell prolifer vitro xenograft tumor growth model show tumor spdef overexpress slower growth rate smaller volum lower weight spdef could direct bind promot region nra promot transcript induc suppress akt mapk nf b signal pathway moreov silenc nra block suppress effect spdef hnscc cell demonstr spdef act tumor suppressor transcript activ nra hnscc find provid novel insight molecular mechan spdef tumorigenesi novel potenti therapeut target hnscc | D063646;D006258 | T191 |
34,667,146 | gene express profil peripher blood lymphocyt major depress preliminari cue chines discord sib pair studi etiolog major depress disord mdd involv mani factor hered environ mdd relat studi chines popul use twin sib pair depress control sampl use microarray approach compar gene express profil peripher blood lymphocyt sib pair discord lifetim histori mdd within sib pair differenti express gene obvious fewer st nd th compar rd th th sib pair gene express pattern deg distinguish mdd individu normal one rd th th sib pair st nd th pair suggest heterogen differ sib pair somewhat common among rd th th sib pair comprehens protein interact network analysi reveal two key gene pth fgf domin network major gene signific regul pth signific regul sib pair fgf rd th th sib pair kegg enrich analysi deg network show pth relat gene signific enrich pathway parathyroid hormon secret synthesi action fgf relat gene signific enrich pathway cancer specif breast cancer general reduc express gene peripher blood lymphocyt mdd individu impli function repress associ mdd pend valid sampl find studi provid valuabl cue understand potenti mechan mdd well potenti marker diagnosi treatment depress chines popul | D003865 | T048 |
34,667,144 | longitudin studi gene express first episod schizophrenia explor relaps mechan co express analysi peripher blood littl known pathophysiolog mechan relaps first episod schizophrenia limit studi potenti biomark explor relaps mechan identifi potenti biomark relaps predict analyz gene express peripher blood cohort first episod schizophrenia patient less year evolut evalu year follow period total particip ep project form sampl baselin gene express analysi provid biolog sampl follow year relaps gene express assess use clariom human array weight gene co express network analysi appli identifi modul co express gene analyz preserv year follow relaps among modul identifi one modul semi conserv relaps darkturquois enrich risk gene schizophrenia show dysregul tcf gene network modul two modul semi conserv relaps year follow darkr darkgrey found biolog associ protein modif protein locat process higher express darkr gene associ higher risk suffer relaps earli appear relaps p find suggest dysregul tcf network could import step biolog process lead relaps suggest gene relat ubiquitin proteosom system could potenti biomark relaps | D012559 | T048 |
34,667,143 | proteom architectur schizophrenia ipsc deriv cerebr organoid reveal alter gwas neuron develop factor schizophrenia scz brain disord typic onset earli adulthood otherwis maintain unknown diseas origin unfortun littl progress made understand molecular mechan under neurodevelop scz due ethic technic limit access develop human brain tissu overcom challeng previous util patient deriv induc pluripot stem cell ipsc generat self develop self matur self organ brain like tissu known cerebr organoid continu prior work provid architectur map develop scz organoid proteom util ipsc n human donor n healthi ctrl donor n scz patient generat cerebr organoid employ plex isobar sampl barcod chemistri simultan subject sampl comprehens high throughput liquid chromatographymass spectrometri lcms quantit proteom protein identifi high throughput proteom profil identifi organoid global proteom landscap differenti regul scz organoid sum protein regul regul scz patient deriv organoid notabl rang neuron factor deplet scz organoid eg map tubb sva gap crabp ncam etc base global enrich analysi alter key pathway regul nervous system develop eg axonogenesi axon develop axon guidanc morphogenesi pathway regul neuron differenti well substantia nigra develop perturb scz patient deriv organoid also identifi promin alter two novel gwas factor pleiotrophin ptn podocalyxin podxl scz organoid sum work serv report resourc research leverag compar contrast orthogon valid scz factor pathway identifi observ clinic studi model system | D057026;D012559 | T025;T048 |
34,667,141 | year old woman primari infertil diagnosi microcyst stromal tumor ovari confirm histolog gene sequenc case report review literatur background microcyst stromal tumor mcst ovari rare entiti distinct patholog molecular featur howev lack awar ovarian mcst lead delay diagnosi misdiagnosi present case ovarian mcst review previous report case discuss clinic patholog characterist case report year old woman primari infertil due polycyst ovari syndrom present bleed pain radiolog imag show complex solid cystic adnex mass microscop tumor lobul cellular region separ fibrous plaqu small anastomos cyst consist ovarian mcst tumor cell show posit stain vimentin cam cd catenin cd cyclin genet sequenc show point mutat ctnnb gene mutat apc brca brca gene patient underw surgeri diseas free month initi diagnosi conclus diagnosi ovarian mcst consid differenti diagnosi cystic tumor ovari research encourag elucid various molecular pathway involv pathogenesi tumor determin optim treatment long term prognosi | D007246;D010051;D018312 | T033;T191;T046 |
34,667,140 | bone involv young adult cystic fibrosi portugues cohort long term survivor cystic fibrosi cf dramat increas risk osteoporosi incid fractur object work character cf relat bone diseas portugues cohort cf patient | D003550;D010024 | T047 |
34,667,128 | new bbb model reveal il blockad suppress bbb disord prevent onset nmosd evalu pathophysiolog neuromyel optica spectrum disord nmosd therapeut mechan level interleukin il blockad satralizumab especi respect blood brain barrier bbb disrupt new vitro ex vivo human bbb model vivo model | D001812;D009471 | T047;T023 |
34,667,127 | target pro surviv protein bcl prevent breast cancer current chemoprevent strategi requir year continu treatment concern signific side effect therefor new chemoprevent agent requir shorter safer treatment urgent need studi develop new murin model breast cancer mimic human breast cancer initi ideal test efficaci chemoprevent therapeut model introduct lentivirus carri pikca gene mutant common found breast cancer infect small number mammari cell lead atypia first ductal carcinoma posit estrogen receptor progesteron receptor venetoclax bh mimet block anti apoptot protein bcl efficaci treat breast cancer found venetoclax treatment atypia bear mice delay progress tumor improv overal surviv reduc pulmonari metastasi therefor prophylact treatment inhibit pro surviv protein bcl may provid altern current avail regimen breast cancer prevent prevent relev studi demonstr prophylact treatment bcl specif antagonist venetoclax prevent breast cancer initi mutat activ pikca common breast oncogen | D001943 | T191 |
34,667,119 | effect sequenc similar detect strobem k mer base method wide use bioinformat various type sequenc comparison howev singl mutat mutat k consecut k mer make k mer base applic sequenc comparison sensit variabl mutat rate mani techniqu studi overcom sensit exampl space k mer k mer permut techniqu techniqu handl indel well indel pair group small k mer common use method first produc k mer match second step pair group k mer perform techniqu produc mani redund k mer match owe size k propos strobem altern k mer sequenc comparison intuit strobem consist two link shorter k mer combin link k mer decid hash function use simul data show strobem provid even distribut sequenc match less sensit differ mutat rate k mer space k mer strobem also produc higher match coverag across sequenc implement proof concept sequenc match tool strobemap use synthet biolog oxford nanopor sequenc data show util use strobem sequenc comparison differ context sequenc cluster align scenario | D000465;D019295 | T091;T170 |
34,667,117 | posit select noncod genom region vocal learn bird associ gene implic vocal learn speech function human vocal learn abil imit sound conspecif environ key compon human spoken languag learn song three independ evolv avian group oscin songbird parrot hummingbird human three bird clade exhibit special behavior neuroanatom brain gene express converg relat vocal learn speech song understand evolutionari basi vocal learn gene special converg search identifi acceler genom region ar marker posit select specif vocal learn bird found avian vocal learner specif ar enrich noncod region near gene known speech function brain gene express special human vocal learn bird includ foxp neurod zeb mefc near gene major neurodevelopment function includ nrf nrp bclb also found enrich near sfari class gene associ syndrom vocal communic form autism spectrum disord find reveal strong candid noncod region near gene evolutionari adapt distinguish vocal learn speci close vocal nonlearn relat provid evid molecular converg birdsong human spoken languag | D020308;D013060 | T040;T054;T012 |
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