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34,667,116
cellular abund shape function pirna guid genom defens defens genom invad univers reli rna guid immun prokaryot crispr cas eukaryot rna interfer pathway recogn target complementari base pair place sequenc guid rnas center selfnonself discrimin explor sequenc space piwi interact rnas pirna genom defens anim establish function prioriti among individu sequenc result reveal topmost abund pirna common present everi cell wherea rare sequenc generat cell cell divers fli mice identifi skew distribut sequenc abund hallmark pirna popul show quantit differ fold establish conserv mechan biogenesi final genom analys direct report assay reveal abund determin function pirna guid genom defens taken togeth identifi effect sequenc space untangl two class pirna differ complex function first class repres topmost abund sequenc drive silenc genom parasit second class spars cover enorm sequenc space rare pirna function everi cell everi individu everi generat creat divers potenti adapt ongo arm race genom invad
D017394
T114;T123
34,667,107
transcript splice dynam earli drosophila develop widespread cotranscript splice demonstr yeast human howev studi date address kinet splice relat transcript use either saccharomyc cerevisia metazoan cultur cell line adapt nativ elong transcript sequenc technolog net seq measur cotranscript splice dynam earli development stage drosophila melanogast embryo result reveal posit rna polymeras ii pol ii canon recurs splice occur found heterogen splice dynam rnas splice immedi intron transcript wherea transcript splice observ first nt downstream exon intron show splice complet pol ii reach end downstream exon necessarili intron defin studi splice dynam nascent pre mrnas transcrib earli embryo short intron well pre mrnas transcrib later embryon develop contain multipl long intron expect found relationship proport splice read intron size howev intron definit observ intron size observ gene transcrib earli embryo tend isol genom wherea gene transcrib later often overlap neighbor converg gene isol gene transcript termin occur soon polyadenyl site overlap gene pol ii persist associ dna templat cleavag polyadenyl nascent transcript taken togeth data unravel novel dynam featur pol ii transcript splice develop drosophila embryo
D012326;D061806
T045
34,667,103
dementia earli stage cognit aid new trial descant memori aid guidanc peopl dementia randomis control trial common memori aid peopl dementia home recommend howev rigor evalu lack particular guidanc support valu
D003704
T048
34,667,102
clinic profil fatal famili insomnia phenotyp variat polymorph geograph region elucid core clinic genet characterist identifi phenotyp variat differ region genotyp fatal famili insomnia ffi
D005838;D010641;D020641
T086;T032
34,667,098
gene month h histon gene hfa hfb histon constitut chief protein compon dna help maintain chromatin structur regul gene express long doubl strand dna molecul wind around histon octam form nucleosom serv purpos compact dna within confin nuclear membran five major type histon name hh h h h h subtyp h histon encod either hfa hfb gene independ amino acid lysin arginin found histon tail site post translat modif ptms methyl acetyl ptms histon involv regul gene express chromatin remodel control dna methyl pattern mutat histon gene affect site ptms caus chang local global dna methyl status effect direct link neoplast transform alter gene express recurr h histon mutat increas identifi sever malign development disord follow review attempt shed light diseas associ h histon mutat
D042002;D019175;D009154
T044;T045
34,667,096
achiev entrust profession activ fellowship entrust profession activ epa develop assess pediatr fellow previous show fellowship program director fpds may graduat fellow still requir supervis compar expect entrust practic subspecialist unknown
D002983;D013038;D035502
T097;T054;T078;T080;T090
34,667,095
attend parti chang youth percept result queensland school particip prevent alcohol risk relat trauma youth program prevent alcohol risk relat trauma youth parti immers day hospit injuri awar prevent programm design educ high school student consequ varieti risk take behaviour multisit contemporari analysi examin differ programm effect tempor chang particip knowledg attitud
D001334;D012574
T092;T073;T056
34,667,093
machin learn approach improv risk stratif secondari cardiovascular diseas prevent multiethn patient identifi high risk patient crucial effect cardiovascular diseas cvd prevent known whether electron health record ehr base machin learn ml model improv cvd risk stratif compar secondari prevent risk score develop randomis clinic trial thrombolysi myocardi infarct risk score secondari prevent trs p
D005006;D000069550
T066;T098;T102
34,667,092
pragmat approach risk assess pulmonari arteri hypertens use european societi cardiologyeuropean respiratori societi guidelin optimis treatment patient pulmonari arteri hypertens pah european societi cardiologyeuropean respiratori societi guidelin recommend use risk stratif aim patient achiev low risk status previous analys registri made progress use risk stratif approach howev focus often patient low risk prognosi wherea pah patient intermedi risk high risk categori use six paramet high prognost relev aim demonstr pragmat approach individu patient risk assess discrimin patient low risk intermedi risk high risk death
D002309;D012042;D012955
T091;T170;T094
34,667,087
choos wise pediatr hospit medicin new recommend improv valu health care system face ongo challeng due low valu care build first pediatr hospit medicin contribut american board intern medicin foundat choos wise campaign work group conven identifi addit prioriti improv health care valu hospit children
D064416;D020445;D008511
T091;T097
34,667,085
hospitalis system lupus erythematosus associ increas risk mortal australian patient longitudin popul level data linkag cohort studi mortal rate patient sle report australia studi determin associ hospitalis sle mortal
D008180
T047
34,667,082
preoper rem sleep behavior disord subthalam nucleus deep brain stimul outcom parkinson diseas year surgeri determin whether patient parkinson diseas pd elig subthalam nucleus deep brain stimul stn dbs probabl rem sleep behavior disord rbd preoper could risk poorer motor nonmotor qualiti life outcom month surgeri compar without rbd
D046690;D010300;D020187;D020531
T048;T047;T023;T061
34,667,080
redund role egfr ligand erk activ wave collect cell migrat epiderm growth factor receptor egfr play pivot role collect cell migrat mediat cell cell propag extracellular signal regul kinas erk activ aim determin egfr ligand mediat erk activ wave found epiderm growth factor egf defici cell exhibit lower basal erk activ cell defici heparin bind egf hbegf transform growth factor alpha tgf epiregulin ereg cell line defici singl egfr ligand retain erk activ wave surpris erk activ wave mark suppress albeit incomplet four egfr ligand knock express egfr ligand reveal hbegf could restor erk activ wave aim complet elimin erk activ wave attempt knockout nrg ligand erbb erbb found nrg defici induc growth arrest absenc four egfr ligand gene collect result show egfr ligand exhibit remark redund propag erk activ wave collect cell migrat
D002465
T043
34,667,079
proser mediat tet glcnacyl regul dna demethyl utx depend enhanc cpg island dna methyl enhanc cpg island usual lead gene repress counteract dna demethyl tet protein famili howev tet enzym recruit regul genom loci fulli understood identifi tet glycosyltransferas ogt previous undescrib prolin serin rich protein proser interactor utx compon enhanc associ mll complex find proser mediat interact ogt tet thus promot tet glcnacyl protein stabil addit proser utx tet ogt coloc mani genom element genom wide loss proser result lower enrich utx tet ogt enhanc cpg island concomit increas dna methyl transcript regul associ target gene increas dna hypermethyl encroach hkme predispos cpg island furthermor provid evid proser act general regul ogt activ control glcnacyl multipl chromatin signal pathway taken togeth studi describ first time regul tet glcnacyl implic mediat dna demethyl utx depend enhanc cpg island support import role proser regul function various chromatin associ protein via ogt mediat glcnacyl
D018899;D000073399;D004742
T114;T045;T123
34,667,075
health care cost hospit young children respiratori syncyti virus infect popul base match cohort studi respiratori syncyti virus rsv infect pose substanti clinic burden among infant young children sought determin health care cost hospit attribut rsv ontario canada health care payer perspect
D017281;D006760;D018357;D022261
T047;T121;T129;T058;T080
34,667,073
pikca mutat case ctnnb mutant sinonas glomangiopericytoma glomangiopericytoma rare primari sinonas tumor exist literatur most limit report describ clinicopatholog characterist tumor comprehens genet character glomangiopericytoma remain lack whole exom sequenc case glomangiopericytoma perform institut review board approv protocol yr old femal underw surgic resect glomangiopericytoma whole exom sequenc reveal somat mutat ctnnb pikca former previous associ patholog latter describ concurr dysregul wnt catenin pikaktmtor signal secondari mutat two oncogen may amen target treatment exist clinic approv drug genom character glomangiopericytoma remain lack studi report novel coexist pikca ctnnb mutat case glomangiopericytoma may offer insight pathogenesi potenti target medic therapi rare tumor
D058534;D051176
T116;T126;T123
34,667,072
matern mosaic missens variant sms gene caus snyder robinson syndrom increas recognit contribut genet mosaic human diseas particular high throughput sequenc enabl detect sequenc variant low allel frequenc describ infant male present mo age hypotonia dysmorph featur congenit heart diseas hyperinsulinem hypoglycemia hypothyroid bilater sensorineur hear loss whole genom sequenc proband parent uncov appar de novo mutat x link sms gene sms encod spermin synthas catalyz product spermin spermidin inactiv sms gene disrupt spermidinespermin ratio result snyder robinson syndrom variant patient absent gnomad exac databas caus missens chang pargci predict damag silico tool although sanger sequenc confirm de novo status proband polymeras chain reaction pcr deep target resequenc depth reveal variant present blood unaffect mother variant allel frequenc find thus provid long sought diagnosi famili highlight role parent mosaic sever genet disord
D038901;D009030
T032;T047
34,667,070
long rang respiratori theta oscil network depend spatial sensori context neural oscil coupl network brain region especi lower frequenc nasal respiratori rhythm elicit robust olfactori bulb oscil link episod memori locomot explor along widespread oscillatori coher piriform cortex implic propag olfactori bulb driven respiratori rhythm test explicit context hippocamp theta nasal respiratori rhythm exploratori behavior investig systemwid interact forag behavior engag respiratori theta rhythm local field potenti olfactori bulb piriform cortex dentat gyrus ca hippocampus primari visual cortex nasal respir record simultan male rat compar interact among area rat forag use either visual olfactori spatial cue found high coher forag compar home cage activ two frequenc band match slow fast respiratori rate piriform cortex hippocampus maintain strong coupl theta frequenc period slow respir wherea pair show coupl fast respiratori frequenc direct analysi show modal spatial cue match larger influenc network respect primari sensori area respiratori theta rhythm also coupl faster oscil primari sensori hippocamp area data provid first evid widespread interact among nasal respir olfactori bulb piriform cortex hippocampus awak freeli move rat support piriform cortex integr respiratori theta activ signific statement recent studi shown widespread interact nasal driven respiratori rhythm neural oscil hippocampus neocortex studi address respiratori rhythm interact ongo slow brain rhythm across olfactori hippocamp visual system freeli move rat pattern network connect chang behavior state stronger interact fast slow respiratori frequenc forag compar home cage activ rout interact sensori cortic depend modal spatial cue present forag function connect cross frequenc coupl analys suggest strong bidirect interact olfactori hippocamp system relat respir point piriform cortex key area mediat respiratori theta rhythm
D012143
T070;T039;T042
34,667,066
spiritu intervent cancer pain systemat review narrat synthesi backgroundpain common debilit cancer relat symptom palliat care physic psycholog social spiritu factor thought contribut individu experi pain consequ spiritu care intervent advoc manag cancer relat pain
D000072716;D009369
T191;T184
34,667,064
clinic outcom longitudin circul tumor dna chang treatment nivolumab olaparib immunotherapi relaps melanoma detect homolog recombin defici treatment immunotherapi relaps cutan melanoma constitut challeng research clinic practic field given lack effect therapeut option homolog recombin defici hrd identifi sever solid cancer includ cutan melanoma howev util medic target hrd cancer cell unchart territori melanoma moreov preclin evid suggest synergist role combin immun checkpoint blockad icb drug target hrd cancer cell parp inhibitor present case studi patient immunotherapi relaps melanoma found detect hrd treat nivolumab icb olaparib parp inhibitor
D000074141;D008545;D012878
T191;T114
34,667,063
potenti benefit treatment mek inhibitor chemotherapi braf mutat kras wild type pancreat ductal adenocarcinoma patient case report first case report yr old femal underw therapi metastat pancreat cancer fluorouracil leucovorin irinotecan oxaliplatin folfirinox upon progress diseas switch gemcitabin nab paclitaxel per genom sequenc tumor found kras wild type braf mutat warrant treatment mek mek inhibitor cobimetinib patient achiev complet respons cr combin gemcitabin nab paclitaxel cobimetinib mo sinc start treatment patient continu demonstr complet durabl respons serolog radiolog
D021441;D010190
T191
34,667,062
prenat hydrop fetali associ infantil free sialic acid storag diseas due novel homozyg delet slca gene nonimmun hydrop fetali excess accumul serous fluid subcutan tissu serous caviti fetus mani possibl etiolog provid diagnost challeng physician lysosom storag diseas report nonimmun hydrop fetali pregnanc infantil free sialic acid storag diseas issd omim sever form autosom recess sialic acid storag diseas issd caus mutat slca omim encod sialin lysosom membran sialic acid transport describ case fetal hydrop due novel homozyg delet slca gene prenat singl nucleotid polymorph snp array analysi perform amniocyt discoveri fetal hydrop wk gestat reveal copi number variant snp array howev report sever region homozygos roh includ one chromosom encompass slca gene high level urin sialic acid newborn detect slca gene sequenc initi sequenc variant identifi howev assay fail amplifi exon prompt exon level copi number analysi reveal novel homozyg delet exon inherit heterozyg carrier parent issd consid workup patient nonimmun hydrop fetali analysi slca delet carri variant detect gene sequenc
D029461
T047
34,667,057
accident lodg airgun pellet maxilla childhood play retriev surgic decad non powder firearm relat injuri head neck carri potenti risk signific morbid mortal penetr injuri tend report trivialis especi children air gun pellet injuri may caus damag soft tissu bone metal embed bodi tissu evok foreign bodi reaction releas toxin time therefor becom imper retriev pellet present one case accident lodgement airgun pellet right maxilla year old boy childhood play airgun went unnot time surgic retriev decad patient suffer neurosensori deficit
D014948;D014950
T037
34,667,052
mntrier diseas patient refractori ulcer coliti clinic challeng review literatur mntrier diseas md rare diseas stomach characteris hypertroph gastric fold lead protein loss associ ulcer coliti uc rare report literatur report case year old male affect uc addit diagnosi md year uc diagnosi uc refractori sever treatment line thiopurin infliximab vedolizumab ustekinumab patient underw colectomi octreotid administ md normalis blood biochemistri effect induc endoscop remiss stomach treatment option patient md uc discuss
D003093;D005758
T047
34,667,051
midbrain infarct inherit protein defici rare associ inherit thrombophil disord well establish predispos factor venous thromboembol role arteri ischaem stroke uncertain exact mechan arteri thrombosi thrombophilia remain elus herein report case year old woman admit facil sudden onset right side ptosi ophthalmoplegia detail clinic featur neuroimag laboratori evalu clinch diagnosi ischaem stroke midbrain due microvascular obstruct associ isol protein defici treat oral anticoagul warfarin physiotherapi without improv symptom month follow high index clinic suspicion need case young ischaem stroke absenc common cardiac vascular risk factor recognis presenc inherit thrombophilia
D002545;D018455;D020521;D019851
T047;T046
34,667,050
eosinophil bronchiol success treat benralizumab year old non smoke japanes woman admit hospit year histori wet cough dyspnoea exert bronchial asthma ba diagnos year earlier although treat high dose inhal corticosteroid experienc frequent exacerb ba short term oral corticosteroid burst occasion administ high resolut ct chest reveal diffus centrilobular nodul bronchial wall thicken patchi ground glass opac lung lung biopsi specimen show widespread cellular bronchiol follicl format membran respiratori bronchiol accompani mark infiltr plasma cell eosinophil addit immunohistochem immunoglobulin g igg stain reveal mani igg posit plasma cell ratio igg posit cell igg posit cell exceed final diagnosi eosinophil bronchiol mark igg posit plasma cell infiltr associ ba benralizumab therapi clinic condit dramat improv
D001249;D001988
T047
34,667,049
segment zoster paresi caus persist fever immunocompromis patient herp zoster reactiv frequent encount condit result sever uncommon complic case report highlight one frequent overlook complic segment zoster paresi discuss case prolong fever lower limb weak immunocompromis patient breast cancer activ chemotherapi resolut herpetiform rash l l l dermatom earli investig lumbar punctur look cerebrospin fluid pleocytosi varicella zoster virus detect pcr molecular test immunoglobulin varicella zoster virus undertaken support diagnosi nerv conduct studi electromyographi mri spine sometim help neurolocalis intraven acyclovir taper cours steroid help resolut symptom varieg present make diagnosi challeng awar high index suspicion prevent delay diagnosi treatment improv patient outcom
D006562
T047
34,667,047
complic persist sever covid pneumonia recipi allogen haematopoiet stem cell transplant describ case year old man affect cell acut lymphoblast leukaemia diagnos covid earli allogen haematopoiet stem cell transplant infecti diseas characteris sever prolong cours complic spontan pneumomediastinum pneumopericardium success treat patient antivir drug remdesivir associ two cours covid convalesc plasma case report repres good exampl typic clinic cours covid sever immunosuppress patient give evid popul prompt treatment direct toward viral clearanc face absenc valid immun reactiv
D000086382;D018352;D018380
T047;T061;T067
34,667,045
left ventricular apic mass myocardi infarct alway thrombus diagnost dilemma myxoma aris left ventricl lv extrem rare easili mistaken thrombus report case year old man present acut cerebrovascular accid prior histori anterior wall myocardi infarct year back echocardiograph evalu show mild lv systol dysfunct present prothrombot workup reveal hyperhomocystinaemia elev level factor viii present echocardiographi reveal mass aris scar lv wall consid possibl thrombus initi start parenter anticoagul unfortun consequ echocardiogram evalu show reduct size lv mass henc surgic remov done histopatholog evalu unveil mass myxoma
D009203;D013927;D018487
T047;T046
34,667,044
favour outcom child acut lymphoblast leukaemia pulmonari mucormycosi manag combin antifung therapi liposom amphotericin b caspofungin pulmonari mucormycosi pm account half case mucormycosi paediatr haematolog malign mortal reach high surgic debrid lesion along liposom amphotericin b l amb constitut mainstay manag mucormycosi offer best chanc surviv reliabl data avail literatur justifi use combin antifung therapi caft describ child acut lymphoblast leukaemia develop multipl localis pm induct chemotherapi manag caft l amb caspofungin view progress pm high dose l amb monotherapi complet resolut pm month caft end intens chemotherapi signific side effect caft caft may valu case mucormycosi refractori high dose l amb surgic debrid feasibl
D009091;D054198
T191;T047
34,667,043
adult cystic nephroma masquerad urotheli carcinoma calyc diverticulum report complex cystic renal lesion year old man present haematuria manag laparoscop radic nephroureterectomi mimick urotheli carcinoma
D002295;D004240;D007680;D001749
T190;T191;T047
34,667,042
right frontal meningioma present delusion parasitosi central nervous system tumour occasion present psychiatr symptom manifest often pose diagnost challeng man earli present psychiatri outpati depart delusion parasitosi old age episod urinari faecal incontin made clinician consid neuroimag first visit detect right frontal meningioma featur intracrani hypertens midlin shift underw emerg surgeri delusion symptom complet resolv surgeri recur follow period year right frontal meningioma present delusion parasitosi probabl report literatur case report highlight rariti present import elicit detail clinic histori need earli neuroimag case
D063726;D008577;D008579
T048;T191
34,667,041
sight threaten progress corneo scleral involv porphyria cutanea tarda porphyria cutanea tarda common type porphyria associ defici uroporphyrinogen decarboxylas enzym respons heme synthesi clinic manifest predomin dermatolog rare present ocular involv although scleral thin interpalpebr area well document entiti sight threaten corneal involv rare describ herein report case year old man present ocular surfac dryness photophobia mild red slit lamp biomicroscopi reveal corneo scleral thin eye diagnosi confirm urin porphyrin test serum iron serum ferritin level start conserv manag lost follow present year total corneal opacif progress loss vision right eye
D005128;D017119
T047
34,667,040
case flexor tenosynov caus mycobacterium arupens mycobacterium arupens member mycobacterium terra complex mtc implic bone joint infect among other group environment pathogen found soil reclaim drink water system rodent fish tank bioaerosol duck hous interest arupens genotyp close relat agent mtc antibiot suscept mycobacteria vari wide empir antibiot therapi controversi case report contribut limit literatur arupens tenosynov six case report sinc shed light differ cours treatment previous case success treat streamlin cours therapi arupens tenosynov still need
D009159;D009165;D013717
T007;T047
34,667,039
non allerg benign infantil proctocol neglect nosograph entiti presenc rectal bleed first month life often diagnos food protein induc allerg proctocol fpiap symptom typic start infanc case resolv age month infant fpiap usual present bloodi stool mix mucus without reduc stool consist affect infant general healthi appear use stori infant rectal bleed remind also possibl form benign non allerg proctocol usual includ differenti diagnosi absenc warn sign case infant well first clinic entiti suspect therefor suggest wait least month start elimin cow milk food diet
D005512;D016269;D011350
T047;T046
34,667,038
bilater iliopsoa abscess present abdomin wall cellul left side empyema thoraci rare present iliopsoa abscess common immunocompromis patient rare present empyema thoraci present year old male comorbid present day histori abdomin pain fever dyspnoea histori tuberculosi recent contact tubercul patient examin patient facial dysmorph abdomin wall cellul extend bilater flank inguinoscrot region chest x ray show left pleural effus ultrasonographi contrast enhanc ct also show bilater iliopsoa abscess left massiv pleural empyema patient underw bilater abscess open drainag thoracostomi left empyema thoraci intraven antibiot therapi patient unev cours postop discharg
D034861;D016724;D016659
T047;T023
34,667,037
sever progress idiopath pulmonari fibrosi post covid infect year old woman present week long histori short breath background idiopath pulmonari fibrosi ipf stabl requir antifibrot treatment month prior present admit covid pneumonia maxim oxygen requir l discharg without need supplement oxygen readmiss found sever rapid progress pulmonari fibrosi precipit caus rule felt recent covid infect exacerb factor caus progress pulmonari fibrosi covid infect hypothesis caus long term pulmonari fibrosi first case highlight covid infect causat agent exacerb ipf
D000086382;D054990
T047;T067
34,667,036
sjgren relat cardiomyopathi present cardiogen shock previous report describ non ischaem cardiomyopathi relat varieti autoimmun diseas howev case report describ sjgren diseas contribut factor cardiomyopathi report case year old woman histori sjgren diseas present cardiogen shock laboratori test cardiac mri reveal apic septal late gadolinium enhanc consist autoimmun aetiolog rule ischaem infecti possibl caus patient clinic present thought relat under sjgren diseas treat intraven steroid evid base heart failur therapi eventu die declin heart transplant given rariti sjgren diseas diagnost criteria standard treatment establish cardiomyopathi relat diseas diagnosi consid patient show evid autoimmun process possibl caus rule
D009202;D012859
T047
34,667,035
human amniot membran therapeut agent pulpotomi perman molar year old woman report carious expos mandibular molar pulpotomi plan rather routin root canal treatment otherwis indic amniot membran extens research differ field medicin use pulpotomi agent gain coron access root orific bleed arrest activ place root stump glass ionom cement gic place membran temporari restor done one week later perman restor composit resin done patient symptom resolv tooth start respond normal vital test subsequ follow up present case report attempt use human natur pulpotomi agent treat irrevers pulpiti perman teeth understand innumer benefici properti applic preserv vital perman teeth main learn object
D000650;D011672
T018;T061
34,667,033
flip triangl use qualiti improv method emb posit behaviour support approach medium secur forens ward men intellectu disabl incid violenc aggress serious concern secur ward peopl intellectu disabl often met increas physic restrict intervent howev intervent usual high risk patient staff ineffectu promot long term behaviour chang studi aim promot posit cultur chang emb evid base practic posit behaviour support shift focus effort use physic restrict intervent manag crise interven posit proactiv prevent crise occur key driver chang involv increas access posit engag opportun expand staff team repertoir proactiv intervent train skill develop support staff well resili chang idea occur alongsid shift cultur promot develop learn cultur psycholog safeti consider contextu fit qualiti improv method help project increas rate posit proactiv intervent decemb januari increas staff knowledg confid safeti also report lesson limit project discuss
D008607;D058996
T048;T057
34,667,030
inactiv ampk lead attenu antigen present immun evas lung adenocarcinoma mutat stk lkb occur lung adenocarcinoma luad drive suppress cold tumor immun microenviron time resist immunotherapi mechan underpin establish mainten cold time lkb mutant luad remain poor understood studi investig role lkb substrat ampk immun evas human non small cell lung cancer nsclc mous model explor mechan involv
D000077192;D002289;D008175
T191
34,667,029
allogen multipl myeloma gm csf secret vaccin lenalidomid induc long term immun durabl clinic respons patient near complet remiss proof principl clinic trial evalu whether allogen multipl myeloma gm csf secret vaccin mm gvax combin lenalidomid could deepen clinic respons patient multipl myeloma sustain near complet remiss ncr
D019496;D018380;D009101
T191;T116;T121;T129;T061
34,667,028
morpholog genom characterist breast cancer occur individu lynch syndrom lynch syndrom defin germlin pathogen mutat involv dna mismatch repair mmr gene link develop mmr defici colon endometri cancer whether breast cancer develop context lynch syndrom causal relat mmr defici mmrd remain controversi thus explor morpholog genom characterist breast cancer occur lynch syndrom individu
D001943;D003123
T191;T047
34,667,027
real world evid support oncolog product registr systemat review new drug applic biolog licens applic approv real world evid rwe garner great interest support registr new therapi label expans unit state food drug administr fda current practic insight design analysi regulatori grade rwe lack studi aim analyz attribut real world studi fda decis make characterist full versus acceler approv systemat review oncolog product approv oncolog approv review fdagov applic screen inclus rwe variabl relat regulatori design applic pivot clinic trial real world studi extract fda feedback review identifi takeaway best practic adequ rwe among origin supplement approv oncolog respect includ rwe none predat real world studi retrospect natur common data sourc chart review common primari endpoint overal respons rate pivot trial fda critiqu lack follow prespecifi studi protocol inclusionexclus criteria match trial compar endpoint definit method minim confound address unmeasur confound plan handl miss data full versus acceler approv share follow characterist high magnitud efficaci pivot trial design orphan diseas breakthrough therapi prioriti review advisori committe meet held studi found find extern control real world studi complement efficaci data singl arm trial success oncolog product approv
D001688;D008495
T091;T121;T123
34,667,026
differ prostat cancer genom self report race contribut genet ancestri modifi cancer risk factor clinic factor black men die prostat cancer twice often white men dispar like due inherit genet modifi cancer risk factor healthcar access incomplet understood tumor genom differ self report race genet ancestri
D011471;D044465
T191;T098
34,667,025
neoadjuv adjuv nivolumab lirilumab patient recurr resect squamous cell carcinoma head neck surgeri often repres best chanc diseas control locoregion recurr squamous cell carcinoma head neck scchn investig dual immun checkpoint inhibit anti pd nivolumab n anti kir lirilumab l salvag surgeri improv diseas free surviv dfs
D020360
T061
34,667,024
high content screen cebp express identifi novel therapeut agent dedifferenti liposarcoma dedifferenti liposarcoma ddls one common aggress sarcoma infrequ respond chemotherapi ddls surviv growth depend underexpress cebp tumor suppressor transcript regul control adipogenesi sought screen priorit candid drug increas cebp express may therefor serv differenti base therapi ddls
D022763;D022762;D008080
T116;T191;T123
34,667,023
neoadjuv chemotherapi immunotherapi lumin b like breast cancer result phase ii giada trial role immunotherapi hormon receptor hr posit negat breast cancer underexplor
D001943;D020360
T191;T061
34,667,022
tempor muscl thick prognost marker patient newli diagnos glioblastoma translat imag analysi centric eortc core trial investig prognost relev tempor muscl thick tmt surrog paramet skelet muscl status patient newli diagnos glioblastoma
D001932;D005909
T191
34,667,018
effect turnov stabil health staff qualiti care remot communiti northern territori australia retrospect cohort studi evalu relationship marker staff employ stabil use short term healthcar worker marker qualiti care secondari object identifi clinic specif factor may counter hypothesis reduc qualiti care associ lower stabil higher turnov higher use short term staff
D006303;D019035
T058;T093;T073
34,667,017
preval strabismus among preschool children eastern china comparison year interv popul base cross section studi updat data strabismus evalu chang preval pattern among preschool eastern china period year
D013285
T047
34,667,016
type diabet incid trend children adolesc age year europ systemat review meta analysi protocol monitor type diabet td trend across european countri use object measur data incid evolv past three decad consid public health prioriti studi protocol provid standardis transpar methodolog assess td trend among year old children adolesc across europ
D003922
T047
34,667,015
healthcar resourc utilis cost associ heart failur diagnosi retrospect popul base cohort studi sweden examin healthcar resourc use hru cost among heart failur hf patient use popul data sweden
D006333
T047;T046
34,667,014
gender differ snowboard accid austria registri analysi elucid gender differ snowboard accid
D001265;D012865
T056;T037
34,667,013
creation electron patient report outcom measur platform vox mix method studi protocol paediatr solid organ transplant patient report outcom measur prom provid opportun meaning patient engag share decis make object research programm improv health outcom paediatr solid organ transplant patient implement prom clinic care current studi aim creat vox paediatr user centr electron prom platform engag patient healthcar provid throughout design develop process
D006282;D016377
T097;T061
34,667,012
psychosoci work factor sick leav risk terrorist bomb attack survey registri base longitudin studi government employe norway studi show social support may reduc negat psycholog effect terror aim explor effect psychosoci work environ sick leav risk among government employe workplac bomb attack
D054042;D023481
T054;T073
34,667,011
multicentr studi evalu effect thermalytix compar standard screen modal subject show possibl symptom suspect breast cancer machin learn comput assist diagnost improv sensit imag analysi reduc time effort interpret compar standard mammogram thermal scan easili scalabl safer screen tool evalu perform thermalytix autom thermograph screen algorithm compar standard breast cancer screen modal
D001943
T191
34,667,010
feasibl multifacet implement intervent improv attend diabet retinopathi screen primari care ireland cluster randomis pilot trial diabet retinopathi screen drs uptak suboptim mani countri limit evid avail intervent enhanc drs uptak primari care investig feasibl preliminari effect intervent improv uptak ireland nation drs programm diabet retinascreen among patient type type diabet
D003924;D003930
T047
34,667,009
studi protocol randomis control clinic trial compar desfluran base versus propofol base anaesthesia postanaesthesia respiratori depress patient obstruct sleep apnoea major abdomin surgeri patient obstruct sleep apnoea osa sensit postanaesthesia respiratori depress whether differ anaesthet regimen intraven base inhal base general anaesthesia affect postanaesthesia respiratori depress controversi although desfluran report present favour rapid recoveri profil special patient includ osa strong clinic evid benefit postanaesthesia respiratori depress far reveal studi aim fill knowledg gap investig postanaesthesia respiratori depress postanaesthesia care unit pacu patient osa major abdomin surgeri follow desfluran base anaesthesia compar propofol base anaesthesia
D018685;D015742;D012131;D020181
T047;T121;T109;T046;T122
34,667,008
financ surgeri anaesthesia sub saharan africa scope review studi aim provid overview current knowledg situat analysi financ surgeri anaesthesia across sub saharan africa ssa
D000758
T061
34,667,007
longitudin studi effect surgic weight loss beat beat blood pressur variabl patient undergo bariatr surgeri studi protocol alter linear non linear paramet beat beat blood pressur variabl bpv shown predict diseas prognosi distinguish risk categori various patholog condit independ averag blood pressur level obes place subject elev risk vascular diseas includ hypertens result serious cardiac respiratori cerebr event howev littl known status vascular dynam obes morbid obes adult
D050110;D006973;D009767
T047;T061
34,667,006
intranas insulin treatment delirium older hospitalis patient studi protocol randomis control trial delirium one common condit diagnos hospitalis older peopl associ numer advers outcom yet proven pharmacolog treatment recent research identifi cerebr glucos hypometabol pathophysiolog mechan offer therapeut target delirium insulin deliv via intranas rout act direct central nervous system shown enhanc cerebr metabol improv cognit patient mild cognit impair dementia trial determin whether intranas insulin reduc durat delirium older hospitalis patient
D003693;D007328
T048;T121;T116;T125
34,667,005
inclus particip low incom middl incom countri core outcom set develop systemat review studi aim describ differ similar scope particip characterist method use core outcom set cos develop particip high incom countri hic involv compar particip low incom middl incom countri lmic also involv
D003906;D011203
T080;T102;T098;T064
34,667,004
experi live type diabet low incom countri qualit studi liberia epidemiolog data type diabet td lowmiddl incom countri particular low incom countri lic includ liberia lack preval lic thought increas td care lic often impact challeng diagnosi manag challeng includ misdiagnosi access insulin affect td outcom frequenc sever complic despit sever natur td grow burden sub saharan africa littl current known impact td patient caregiv region
D003922
T047
34,667,003
retrospect analysi characterist associ higher valu radiotherapi episod care bone metastas medicar fee servic beneficiari center medicar medicaid servic newli enact radiat oncolog model ro model design test cost save potenti prospect episod base payment radiat treatment cancer diagnos encourag high valu care effici care deliveri bone metastas evid support use higher valu shorter cours radiat fraction goal determin preval short radiat cours fraction bone metastas set treatment patient characterist associ cours expenditur
D018787
T091
34,667,002
protocol test efficaci safeti frequent applic skin electr stimul leber hereditari optic neuropathi singl arm open label non randomis prospect studi leber hereditari optic neuropathi lhon acut subacut inherit optic neuropathi caus mitochondri mutat patient lhon one three point mutat ie ga ga tc previous report week session skin electr stimul ses week interv signific improv visual acuiti field test week last stimul without advers effect case lhon carri mt dna ga mutat present studi examin magnitud persist efficaci presenc absenc advers event use ses frequent stimul protocol
D029242
T047
34,667,001
doctor ca nt doctor time qualit studi general practition medic student negoti public profession privat person realm use social media object studi explor experi perspect general practition medic student use behaviour social media understand negoti threat profession person life social media
D058005;D061108;D013337
T097;T170
34,667,000
perceiv effect financi risk protect urban rural resid basic medic insur scheme mix method studi rural resid china explor perceiv financi risk protect effect urban rural resid basic medic insur scheme urrbmi influenc factor provid evid improv urrbmi
D007341;D012424
T081;T102;T098;T078
34,666,999
factor associ shorter length admiss among peopl dementia england wale retrospect cohort studi identifi aspect organis deliveri acut inpati servic peopl dementia associ shorter length hospit stay
D003704
T048
34,666,998
efficaci left ventricular unload strategi venoarteri extracorpor membran oxygen patient cardiogen shock protocol systemat review bayesian network meta analysi venoarteri extracorpor membran oxygen va ecmo wide use patient refractori cardiogen shock common side effect technic result increas left ventricular lv afterload could potenti aggrav myocardi ischaemia delay ventricular recoveri increas risk pulmonari congest sever lv unload strategi propos implement mitig complic howev still indistinct one best choic clinic applic bayesian network meta analysi nma aim compar efficaci differ lv unload strategi va ecmo
D015199
T061
34,666,997
multilevel factor influenc contracept use childbear among adolesc girl bara district nepal qualit studi use socioecolog model studi aim identifi multilevel factor influenc contracept use childbear decis nepal examin relationship among factor
D003267;D003270
T039;T121;T061
34,666,996
combinatori crispr cas screen identifi ifenprodil adjunct sorafenib liver cancer treatment systemat test exist drug combin attract strategi exploit approv drug repurpos identifi best action treatment option expedit search among mani possibl drug combin design combinatori crispr cas screen inhibit druggabl target coblockad n methyl aspart receptor nmdar target first line kinas inhibitor reduc hepatocellular carcinoma hcc cell growth clinic hcc patient low nmdar express show better surviv clinic approv nmdar antagonist ifenprodil synerg sorafenib induc unfold protein respons trigger cell cycl arrest downregul gene associ wnt signal stem reduc self renew abil hcc cell multipl hcc patient deriv organoid human tumor xenograft model drug combin neither singl drug alon mark reduc tumor initi cancer cell frequenc ifenprodil establish safeti histori use vasodil human find support repurpos drug adjunct hcc treatment improv clinic outcom reduc tumor recurr result also valid approach readili discov action combin cancer therapi signific combinatori crispr cas screen identifi action target hcc therapi uncov potenti combin clinic approv drug ifenprodil sorafenib new effect treatment regimen
D064113
T040
34,666,994
pattern carbon bound exogen compound patient lung cancer associ diseas pathophysiolog asymptomat anthracosi accumul black carbon particl adult human lung common occurr pathophysiolog signific anthracosi debat use situ high mass resolut matrix assist laser desorptionion maldi fourier transform ion cyclotron reson ft icr mass spectrometri imag analysi discov noxious carbon bound exogen compound polycycl aromat hydrocarbon pah tobacco specif nitrosamin aromat amin seri patient lung cancer high variabl uniqu pattern characterist natur carbon bound exogen compound strong associ patient outcom tumor progress tumor immun microenviron program death ligand pd l express dna damag spatial correl network analys reveal substanti differ metabolom tumor cell compar tumor stroma depend carbon bound exogen compound overal bioactiv pool exogen compound associ sever chang lung cancer pathophysiolog correl patient outcom given high preval anthracosi lung adult human futur work investig role carbon bound exogen compound lung carcinogenesi lung cancer therapi signific studi identifi bioactiv pool carbon bound exogen compound patient tissu associ sever tumor biolog featur contribut improv understand driver lung cancer pathophysiolog
D055442;D059016
T070;T039
34,666,993
neoadjuv situ immunomodul enhanc system antitumor immun high metastat tumor neoadjuv immunotherapi given surgic resect promis approach develop system antitumor immun treatment high risk resect diseas use syngen orthotop mous model tripl negat breast cancer test hypothesi generat tumor specif cell respons induct activ tumor resid batf depend convent type dendrit cell cdc resect improv control distant metastat diseas surviv mice bear high metastat orthotop tumor treat combinatori situ immunomodul isim regimen compris intratumor administr fltl local radiotherapi situ tlrcd stimul follow surgic resect neoadjuv isim neo isim generat tumor specif cd cell infiltr distant nonirradi metastat site delay progress lung metastas improv surviv resect primari tumor efficaci neo isim depend de novo adapt cell immun elicit batf depend dendrit cell enhanc increas dose fraction radiotherapi earli surgic resect complet neo isim import neo isim synerg program cell death protein ligand pd l blockad improv control distant metastas prolong surviv remov tumor drain lymph node abrog antimetastat efficaci neo isim find illustr therapeut potenti neoadjuv multimod intralesion therapi treatment resect tumor high risk relaps signific neoadjuv induct activ cdcs primari tumor enhanc system antitumor immun suppress metastat progress improv surviv synerg anti pd l therapi
D056747
T061
34,666,990
bicycl peptid make target epha possibl tumor penetr bicycl peptid deliv toxic payload may final unlock therapeut potenti target epha accord phase trial data bt yield clinic respons three patient ovarian urotheli cancer without toxic issu plagu epha direct therapeut candid
D000970;D036104;D001749
T116;T191;T121;T109;T192;T126
34,666,989
vaccin nation intern perspect covid vaccin trial particip unit kingdom vaccin nation becom key topic discuss develop test rollout covid vaccin media attent highlight way global coordin access vaccin limit pandem also expos countri secur vaccin suppli bilater purchas agreement way pharmaceut compani price negoti deliv suppli much focus debat vaccin suppli winner loser voic public opinion limit
D000086382;D014612
T116;T047;T121;T129;T067
34,666,988
systemat analysi authorship demograph global surgeri global surgeri recent gain promin academ disciplin within global health authorship inequ consist featur global health public represent author high incom countri hic disenfranchis research low incom middl incom countri lmic studi investig authorship demograph within recent publish global surgeri literatur
D001319;D003906
T080;T057
34,666,981
acut urinari retent risk cancer popul base danish cohort studi examin risk urogenit colorect neurolog cancer first diagnosi acut urinari retent
D015179;D009423;D018570;D016055;D014565
T191;T033;T058;T080;T062
34,666,979
addict treatment india legal ethic profession concern report media per magnitud substanc use india survey report million indian popul need profession help alcohol use disord around million opioid use disord increas demand addict treatment servic india call professionalis everi aspect field frequent human right violat various uneth practic indian addict treatment facil report mass media studi content analysi newspap report januari decemb look legal ethic profession concern regard treatment substanc use disord india content analysi reveal various human right violat use improp treatment modal lack basic facil treatment set presenc unqualifi profession practic
D000437;D019966
T033;T048
34,666,978
spiral episod domest violenc incred common document law india sinc preval domest violenc high india close percent per nation famili health survey yet intervent dilaasa maharashtra bhoomika kerala sukoon haryana among other visibl increas support seek behaviour narrat base person observ extens imagin built give structur narrat jar saw consequ violenc debilit violenc beget violenc becom question conting power flow survivor creat survivor
D017579
T048;T054
34,666,977
liquid miscreant alcohol social issu undermin today set work aim plung reader plight direct indirect victim alcohol abus
D000437
T048
34,666,976
narrat endur ethic listen commentari ethic listen glean two narrat drawn real life encount craft mode fiction spiral rakhi ghoshal liquid miscreant aiswarya sasi narrat indign inflict alcohol famili individu narrat instanc outsid listen bear wit suffer resist wit commentari argu narrat offer reader opportun reflect entail ethic listen henc suggest compon activ dynam ethic listen entail empathet presenc non intrus recept bear wit compass
D004645;D033262
T170;T078;T054;T055
34,666,974
opposit haryana govern medic educ direct fee hike recent direct haryana govern link mbbs cours offer state govern medic colleg annual bond rs lakh move oppos medic aspir medic student well medic associ reduc avenu afford medic educ inde grave concern need consid
D004501;D013337
T097;T065
34,666,973
research biomedicin ayurveda evid base medicin evid inform healthcar search effect treatment covid intensifi tradit medicin system receiv increas attent research well public scientif rigour non negoti remain fundament issu address bring evid tradit system examin issu pertain ayurveda under philosoph underpin suggest potenti way move forward find abil emerg cage biomed foundat reduction essenti appropri research ayurveda caution pursu research ayurveda mimick modern medicin highlight need appropri use modern scienc tool method understand ayurveda explor potenti healthcar emphasis need potenti transdisciplinari research ayurveda balanc evid base medicin evid inform healthcar requir
D000086382
T047;T067
34,666,972
telemedicin ethic opportun india prior covid pandem telemedicin upcom modal diagnosi treatment limit inadequ guidelin legisl pandem polici maker worldwid found prudent set forth new telemedicin guidelin eas regul oper govern india along board governor supercess medic council india amend indian medic council act publish telemedicin practic guidelin lay framework telemedicin practic countri step provid medico legal context deliveri onlin health servic howev guidelin present form part address ethic aspect telemedicin india briefli describ guidelin highlight ethic concern surround teleconsult process countri also suggest possibl solut ethic issu surround practic telemedicin
D000086382;D017216
T058;T047;T067
34,666,971
challeng govern biomed health research public new drug clinic trial rule articl pertain govern biomed health research public new drug clinic trial rule new regul cover type research howev concern biomed health research may fall short certain count regard review studi vulner popul undertak risk benefit analysi find related case serious advers event provid compens challeng face ethic committe incept studi complet discuss need rigor train member involv ethic committe function
D035843;D004364
T062;T121
34,666,970
commercialis healthcar india covid beyond review govern polici pandem flag number ethic concern privat healthcar sector treatment covid patient generat mistrust anger howev govern held account instead commercialis subvert pandem need govern hospit weaken decad cut expos intern reorganis servic public privat partnership mechan neoliber polici persist pandem need examin govern polici relianc scale coverag privat sector pandem
D000086382
T047;T067
34,666,969
examin signific ethic covid overview proceed th nation bioethic confer year go histori year covid pandem enorm challeng pose ordinari peopl expert across disciplin worldwid covid broke wuhan decemb soon spread rapid till march world health organ declar pandem accord latest statist worldwid total case covid death
D001675;D000086382
T091;T047;T067
34,666,968
keshav desiraju mental health matter keshav desiraju former union health secretari pass away septemb uncommon bureaucrat extraordinari human mani obituari eulog written contribut public health india person qualiti help need focus specif contribut mental health sector india contribut signific last year health bureaucrat even retir
D008603;D011634
T091;T041
34,666,967
examin women health psychosoci len copasah global symposium group therapist mental health practition tri highlight issu women mental health two specif focus one live experi person live mental ill secondari burn shame face caretak second session explor contour somatis often seen human bodi result impact trauma particip reflect valu live experi also discuss challeng face get represent peopl live mental ill challeng list particip concentr around particip represent person live intellectu disabl psychosoci disabl somatis traumat experi need recognit countri like india women life stressor exist right childhood keep threshold mental ill andor psychosomat ill psychosoci health issu releg subordin categori discuss public health reproduct health health right featur mainstream discuss various seminar research confer india paper base two session copasah global symposium focus gender psychosoci dimens health framework women subject unpaid care work social reproduct labour stressor result psycho social distress end import build communiti practition look beyond reproduct health women
D006297;D001523
T033;T048;T080
34,666,966
appreci complex chang context account challeng sexual reproduct health right social account fast recognis import strategi realis sexual reproduct health right howev predomin approach tend focus use top monitor account tool captur complex polit surround deepli contest terrain paper draw discuss took place copasah global symposium octob grassroot practition share experi seek account reflect myriad challeng process paper call greater nuanc awar context design implement social account intervent engag power polit forc determin peopl access srh right
D060728;D000074384
T091;T032
34,666,965
advanc agenda peopl centr account privat healthcar sector themat track account privat corpor healthcar sector copasah global symposium aim analys emerg global trend commercialis health system transit healthcar public good market commod cost public fund healthcar develop countri examin implic lack state regul oversight enabl profit driven privat healthcar sector exploit vulner peopl overcharg malpractic violat patient right final session address challeng advocaci patient right showcas effect campaign strategi use health activist differ countri promot account privat healthcar sector put togeth learn insight track help contribut toward power global counter narrat provid activist tool creat awar engag critic issu
D019981;D017149
T057;T098;T169;T093;T078
34,666,964
communiti particip demand account health system strengthen paper describ copasah global symposium treat theme communiti action govern account health system strengthen first lay copasah understand social account health system centr stage transform potenti power communiti rather see social account mere tokenist particip communiti case studi present practition across globe theme posit communiti civil societi larg central govern account health system public privat import role contextu analysi defin strategi intervent demand account discuss particip experi demand account brought clear import linkag local action global mobilis discuss reaffirm copasah principl social account health inform copasah charter call action social account health
D003256;D012941
T052;T054;T078
34,666,963
centr stage citizenship power communiti account discours overview paper distil key insight themat inter themat deliber global symposium citizenship govern account health describ evolut symposium theme link account citizenship govern health provid overview symposium paper synthesis key discuss core theme lay analyt reflect emerg deliber touch upon issu power polit surround account viz civil societi democraci power civic space role privat non state actor affect health right marginalis
D006297;D006806
T089;T064;T078;T033;T080
34,666,962
infertil unfinish reproduct right agenda india twenti five year intern confer popul develop icpd mandat india fallen far short provid univers access prevent treatment servic infertil mandat call priorit reproduct health right peopl reproduct health defin
D007246;D046269
T033;T046;T078
34,666,960
might take time studi evolut qualiti life individu gender incongru gender affirm care distress caus gender incongru shown reduc gender affirm care current studi follow cohort patient request gender affirm care ghent univers hospit examin outcom procedur
D000068116;D063106;D014189
T032;T048;T098
34,666,957
parent peer norm uniqu correl covid vaccin intent divers sampl us adolesc recent studi document worrisom level hesit resist covid vaccin includ within adolesc popul studi examin attitudin perceiv sever covid vaccin relat concern interperson parent peer norm anteced adolesc intent receiv covid vaccin
D000086382;D000086663
T047;T200;T067
34,666,956
ensur adolesc patient portal confidenti age cure act final rule manag confidenti adolesc health inform patient portal present uniqu challeng adolesc patient guardian electron access medic record communic provid via portal confidenti matter like sexual health ensur confidenti crucial key aspect confidenti portal ensur account regist util intend user inappropri regist guardian access adolesc portal account may lead confidenti breach
D016497;D000072638
T058;T170
34,666,954
adolesc digit stress frequenc correl longitudin associ depress symptom adolesc among frequent user social media high attun social feedback howev digit stress subject distress relat social media demand expect other approv judgment understudi adolesc
D000294;D061108
T170;T055
34,666,953
covid vaccin sentiment among african american black adolesc rural alabama consid urgent need increas vaccin uptak alabama rural state lowest rate covid vaccin countri conduct exploratori studi elucid sentiment toward vaccin among african american black adolesc conduct depth interview year old rural alabama n sampl femal near third live older famili member knew someon contract covid use rapid qualit analysi covid vaccin relat theme emerg influenc communiti leader older famili member fear side effect misinform institut distrust address covid vaccin hesit among rural african american black adolesc suggest adopt socioecolog approach public health messag address misinform govern distrust deliv local influenc social capit necessari promot behavior chang name older famili member church offici
D000086382;D014612
T116;T047;T121;T129;T067