PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,666,760 | matern feed practic toddler fruit veget consumpt result dit coomb hospit birth cohort ireland health benefit fruit veget well recogn howev insuffici consumpt fruit veget preval among toddler becom global public health issu matern feed practic potenti factor influenc toddler dietari intak includ fruit veget intak studi conduct explor influenc matern feed practic toddler fruit veget consumpt ireland | D005638;D014675 | T002;T168 |
34,666,757 | impact clinic phenotyp manag outcom european atrial fibril patient report esc ehra eurobserv research programm af eorp af general long term registri epidemiolog studi atrial fibril af illustr clinic complex increas risk major advers outcom aim describ european af patient clinic phenotyp analys differenti clinic cours | D001281 | T047;T046 |
34,666,756 | understand factor affect appropri rheumatolog referr reduc inappropri referr specialist challeng healthcar system seek transit volum valu base healthcar given project sever shortag rheumatologist near futur innov strategi decreas demand rheumatolog servic may prove fruit increas suppli rheumatologist effort increas appropri util reduct capac may unintend consequ reduc appropri care well highlight challeng increas appropri use high cost servic health system transit valu base care object studi analyz factor affect appropri rheumatolog servic | D012219 | T091 |
34,666,755 | social particip unifi health system brazil exploratori studi adequaci health council resolut social particip one guidelin brazilian health system health council collegi instanc particip establish law recent legal regul council organ function establish resolut institut health council perman delib natur act formul deliber control health polici implement includ econom financi aspect | D011057;D058992 | T057;T055;T068;T078;T054;T090 |
34,666,754 | impact famili member health care experi patient trust physician famili member negat experi medic care long term effect patient attitud emot howev impact famili member experi patient trust physician physician general poor understood studi aim quantifi associ | D010820;D035502 | T097;T054 |
34,666,753 | assess qualiti routin health inform system data associ factor among depart public health facil harari region ethiopia despit improv knowledg understand role health inform global health system qualiti data generat routin health inform system still poor low middl incom countri pauciti studi determin data qualiti health facil studi area therefor studi aim assess qualiti routin health inform system data associ factor public health facil harari region ethiopia | D063005 | T170 |
34,666,749 | mix method survey physiotherapist practic acupunctur dri needl ontario canada practic characterist motiv profession outcom physiotherapist pts across globe increas incorpor filiform needl techniqu eg acupunctur dri needl clinic toolkit evid base complementari therapi becom progress robust howev date littl known needl pts | D015670;D000079245;D007722;D059825 | T097;T053;T061 |
34,666,747 | secular trend age menarch yunnan provinc china multiethn popul studi women age menarch aam shown differ trend women differ ethnic econom region recent decad data aam among multiethn women live develop area scarc | D008572;D012424 | T040;T098;T102 |
34,666,745 | impact multimorbid level function limit accuraci use self report survey data compar administr data measur general practition specialist visit communiti live adult research often use survey data studi effect health social variabl physician use self report physician use compar administr data gold standard particular within context multimorbid function limit remain unclear examin whether multimorbid function limit relat agreement self report administr data physician use | D058005;D000076322 | T097;T078 |
34,666,744 | valid reliabl persian version self evalu negat symptom sns self evalu negat symptom sns develop allow schizophrenia patient evalu five dimens negat symptom present studi aim examin psychometr properti persian version sns | D059026;D012559 | T048;T041 |
34,666,743 | good caus intent problem appli doctrin doubl effect palliat sedat palliat sedat analgesia employ patient refractori intract symptom end life reduc suffer lower level conscious doctrin doubl effect philosoph principl justifi good action potenti bad effect frequent employ provid ethic justif practic | D033182;D013727 | T058;T041 |
34,666,742 | examin effect place base intervent improv public health reduc health inequ umbrella review local deliv place base public health intervent receiv increas attent way improv health reduc inequ howev limit evid effect umbrella review synthesis systemat review evid health health inequ impact local deliv place base intervent across three element place health physic social econom environ | D054624;D011634 | T091;T080 |
34,666,741 | substanc use famili member communiti affect substanc use among adolesc boy evid udaya studi india substanc use among adolesc riski behavior emerg concern develop develop countri evid reveal substanc use frequent among adolesc whose immedi famili member parent sibl grandpar also indulg consumpt howev scarc literatur present indian context therefor present studi examin whether substanc use among famili member communiti associ substanc use behavior adolesc boy uttar pradesh bihar | D000294;D019966 | T033;T048;T055 |
34,666,740 | effect public health intervent first epidem wave covid cyprus model studi cyprus address first wave sar cov covid implement non pharmaceut intervent npis aim studi estim epidemiolog paramet wave includ infect attack ratio infect fatal ratio case ascertain ratio b assess impact public health intervent examin would happen intervent implement | D000086382;D058872 | T047;T067 |
34,666,739 | associ preoper oh vitamin level postop complic patient undergo colorect cancer surgeri determin modifi risk factor postop complic particular signific patient undergo colorect surgeri sinc associ wors long term outcom | D015179;D013505;D014808 | T191;T047;T061 |
34,666,738 | prenat prognost factor isol right congenit diaphragmat hernia singl center experi right side congenit diaphragmat hernia rcdh relat rare compar left side congenit diaphragmat hernia lcdh clinic data rcdh especi respect antenat predict neonat outcom lack aim studi report treatment outcom patient antenat diagnos rcdh evalu predict observ expect lung area head circumfer ratio oe lhr perinat outcom focus mortal extracorpor membran oxygen ecmo requir | D065630 | T019 |
34,666,737 | nation cohort studi hemodialysi arterioven fistula kidney transplant long term patenc use complic describ long term hemodialysi arterioven fistula avf patenc incid avf use incid natur avf complic surgeri patient kidney transplant | D016030;D006435 | T061 |
34,666,736 | job craft promot intern recoveri state especi job demand self control daili diari design research employe recov work focus primarili recoveri non work hour extern recoveri rather recoveri work hour intern recoveri use conserv resourc theori conceptu framework test whether job craft promot intern recoveri state examin process explain associ | D004651;D000068356 | T033;T080;T098;T055 |
34,666,735 | contribut clinic breast exam cancer detect women particip modern screen program despit controversi surround role clinic breast exam cbe modern breast cancer screen wide practic examin contribut cbe women undergo routin screen mammographi women screen age | D001943;D008327 | T191;T060 |
34,666,734 | return work subacromi decompress diagnost arthroscopi exercis therapi shoulder imping randomis placebo surgeri control fimpact clinic trial five year follow arthroscop subacromi decompress one common perform shoulder surgeri world perform treat patient suspect shoulder imping syndrom ie subacromi pain syndrom studi specif assess return work rate subacromi decompress surgeri exist evid come open unblind studi design lack blind introduc potenti bias assess return work predictor patient shoulder imping syndrom secondari analysi placebo surgeri control trial | D019534 | T047 |
34,666,733 | factor impact test base manag suspect malaria among caregiv febril children privat medicin retail within rural communiti fanteakwa north district ghana prompt diagnosi treatment prevent mild case malaria develop sever diseas death unfortun parasitolog test febril children greater public formal privat sector inform privat sector sub saharan africa | D000962;D037621;D008288 | T047;T121;T109 |
34,666,732 | prognosi chang landscap palliat home care client experi high rate pain nausea regardless prognosi individu typic receiv palliat care pc tend cancer relat short prognosi month peopl life limit ill also benefit palliat care approach howev littl known receiv palliat home care ontario canada largest provinc address gap goal project understand need symptom potenti differ shorter month longer prognosi month individu receiv pc communiti | D006699;D010166 | T058;T061 |
34,666,731 | method crack detect base digit imag correl simul crack tooth earli clinic crack tooth perplex disord diagnos manag one key problem diagnosi crack tooth detect locat surfac crack | D003387;D014070;D014082 | T033;T023;T037 |
34,666,730 | relationship affect upper limb function daili activ perform children cerebr palsi cross section studi differ role affect less affect upper limb children cerebr palsi cp howev lack studi relationship affect limb function activ daili live adl children cp thus aim prospect cross section studi investig relationship affect upper limb function adl children cp | D000203;D002547 | T080;T047;T019;T056 |
34,666,729 | salutari effect periton dialysi cathet enhanc recoveri among high risk pediatr patient undergo left coronari transfer procedur cohort studi evid periton dialysi cathet pdc usag pediatr patient undergo surgeri deterior cardiac dysfunct lack investig explor factor associ pdc usag effect children anomal origin left coronari arteri pulmonari arteri alcapa | D063748;D010530 | T047;T061 |
34,666,728 | pumpkin seed oil cucurbita pepo versus tamsulosin benign prostat hyperplasia symptom relief singl blind random clinic trial benign prostat hyperplasia bph common age men aim compar effect tamsulosin pumpkin cucurbita pepo seed oil bph symptom | D028464 | T002;T168 |
34,666,727 | associ circul hydroxyvitamin concentr hip replac osteoarthr prospect cohort studi examin associ circul oh concentr incid total hip replac osteoarthr prospect cohort studi | D019644;D015207 | T047;T061 |
34,666,726 | cultur context pandem qualit descript cultur factor shape protect behaviour chines canadian communiti covid pandem signific variat level adopt public health recommend across intern jurisdict cultur group variat contribut dissimilar level risk associ world chang viral infect highlight potenti role cultur assign mean import person protect behaviour purpos studi describ cultur factor covid pandem shape protect health behaviour chines canadian communiti one largest chines diaspora outsid asia | D000086382;D058873 | T047;T067 |
34,666,725 | diagnost valu monocyt chemoattract protein solubl mannos receptor presepsin procalcitonin critic ill children admit suspect sepsi differenti system inflammatori respons syndrom sepsi import determin essenti treatment decis select initi durat antibiot therapi | D000077740;D018805 | T116;T047;T046;T123 |
34,666,724 | evalu effect cost effect strengthen famili strengthen communiti group base parent programm studi protocol initi insight uk children experi socio emot difficulti serious implic famili societi stark socioeconom ethnic inequ children well exist support parent develop effect parent skill import prevent strategi reduc inequ parent intervent develop aim reduc sever impact difficulti howev parent intervent uk focus earli childhood year often fail engag famili ethnic minor group live poverti strengthen famili strengthen communiti sfsc parent programm design race equal foundat aim address gap evid preliminari studi encourag randomis control trial undertaken far | D016487;D011788 | T054;T078 |
34,666,723 | impact child migrat health status health care util older parent chronic diseas left behind china adult child use take respons take care older parent chines cultur howev migrat adult child uncommon context urban china purpos studi explor impact child migrat health status health care util older parent chronic diseas left behind | D006304;D010342 | T058;T080;T055 |
34,666,722 | trajectori depress symptom among work adult covid pandem longitudin analysi inhamilton covid studi longitudin studi examin impact chang covid pandem relat stressor experi cope style mental health trajectori employ individu lockdown limit studi examin mental health trajectori sampl employ adult hamilton ontario initi lockdown open follow first wave canada studi also identifi pandem relat stressor cope strategi associ chang depress symptom employ adult covid pandem | D000086382;D058873 | T047;T067 |
34,666,721 | explain util hiv prevent test servic among univers student mozambiqu result mix method studi mozambiqu hiv infect disproportion affect young adult particular women despit awar knowledg hiv transmiss mani univers student receiv hiv test continu engag high risk sexual behavior includ inconsist condom use understand pattern engag hiv prevent test key reduc hiv transmiss risk popul | D015658 | T047 |
34,666,720 | comparison surgic induc astigmat anterior total cornea mm steep meridian incis cataract surgeri studi aim compar surgic induc astigmat sia anterior total cornea cataract surgeri mm steep meridian incis | D001251;D002386;D016740;D018918 | T047;T190;T061;T033;T029 |
34,666,719 | explor condom use decis make among adolesc synergist role affect ration process condom use remain effect behaviour method prevent hiv unplan pregnanc howev condom use remain inconsist among young peopl explor condom use decis make process adolesc engag might provid inform would assist prevent mani challeng relat poor sexual reproduct health outcom studi therefor aim explor factor influenc decis make sexual debut condom use adolesc two school western cape south africa | D000294;D017280 | T074;T057;T055 |
34,666,718 | explor potenti output measur assess effici product labour birth australia matern servic area healthcar increas emphasi place improv effici product first step effici product analysi select relev input output measur within healthcar quantifi produc output difficult aim paper identifi potenti output measur use assess effici product labour birth hospit care australia assess extent reflect principl woman centr care | D004526;D017063 | T062;T057;T081 |
34,666,717 | variant identifi next generat sequenc caus endoplasm reticulum stress rhodopsin associ retin pigmentosa rhodopsin rho well known genet caus autosom domin retin pigmentosa adrp studi aim investig genet caus larg chines adrp famili assess pathogen detect rho mutant | D012174;D012243 | T116;T047;T123 |
34,666,716 | mycobacteria avium relat periton patient undergo periton dialysi case report review literatur mycobacteria avium avium speci ubiquit slowli grow nontubercul mycobacteria caus opportunist infect howev avium relat periton periton dialysi pd patient rare | D009162 | T007 |
34,666,715 | alcohol polici complianc among retail bhutan multisit communiti intervent studi alcohol use major public health problem bhutan complianc regul point sale import strategi alcohol control retail outlet brief sale regul provid notif rule direct display premis extent licens alcohol outlet respond possibl alcohol purchas assess use young proxi purchas adult feign alcohol intox sober adult total visit pre versus post visit made across four district town two town damphu town tsirang district pema gatshel town pema gatshel district receiv pre post intervent purchas survey two neighbour town khuruthang town punakha bajo town wangdu administ baselin survey | D000435;D019983 | T058;T048;T064 |
34,666,714 | classif move coronari calcifi plaqu base motion artifact use convolut neural network robot simul studi influenti factor motion artifact affect imag coronari calcifi plaqu studi util convolut neural network cnns classifi motion contamin imag move coronari calcifi plaqu determin influenti factor classif perform | D016571;D012371;D014057 | T170;T060;T090 |
34,666,713 | psychometr properti dementia knowledg assess scale tradit chines among home care worker taiwan dementia knowledg assess scale dkas reliabl valid measur dementia knowledg divers alli health profession tradit chines version formal valid yet purpos studi translat dkas english tradit chines evalu psychometr properti among home care worker taiwan | D003704;D006699 | T058;T048 |
34,666,712 | immunoglobulin nephropathi first clinic present wilson diseas case report literatur review wilson diseas wd rare genet disord copper metabol differ copper tissu accumul lead various clinic manifest includ atyp present complex clinic featur wd make diagnosi challeng delay best chanc treatment | D005922;D006527 | T047 |
34,666,711 | implement advanc care plan earli dementia care result insight pilot intervent trial advanc care plan acp particular appropri person earli dementia pwed sinc promot convers dementia specif ill scenario address inconsist advanc direct patient observ behavior emphas prospect relat autonomi may general consist older person decis make need howev despit evid benefit acp yet becom wide use among pwed paper present dementia specif tool develop western switzerland discuss result pilot trial design promot acp among pwed relat discuss feasibl accept intervent studi protocol previs larg scale trial | D032722;D003704 | T058;T048 |
34,666,710 | impact covid pandem rhegmatogen retin detach treatment pattern describ chang rhegmatogen retin detach rrd surgic procedur beij covid pandem | D000086382;D012163 | T047;T067 |
34,666,709 | manag outcom critic ill nonagenarian versus octogenarian patient intens care unit icu patient age year older repres grow subgroup place huge financi burden health care resourc despit benefit unclear lead ethic problem present investig assess differ outcom nonagenarian octogenarian icu patient | D016638;D000073496 | T033;T047;T184;T046 |
34,666,708 | clinic outcom endoscop remov foreign bodi upper gastrointestin tract ingest foreign object frequent requir emerg remov studi aim investig clinic outcom endoscop remov foreign bodi upper gastrointestin tract risk factor advers event | D005547;D041742 | T017;T072;T037;T020 |
34,666,707 | predictor sever leptospirosi multicentr observ studi central malaysia leptospirosi emerg diseas vast clinic present rang subclin mild sever fatal outcom leptospirosi manag well diagnos earlier howev similar clinic present sever febril ill co infect laboratori diagnost challeng due biphas natur ill often result mis underdiagnosi therebi lead sever ill identif clinic predictor sever form diseas play crucial role reduc diseas complic mortal therefor aim determin clinic predictor associ sever ill among leptospirosi patient central malaysia prospect multicent observ studi | D058186;D007922 | T047;T037 |
34,666,706 | de novo variant polrb caus demyelin charcot mari tooth diseas chines patient case report charcot mari tooth cmt diseas group inherit peripher neuropathi subdivid demyelin axon form biallel mutat polrb well establish caus hypomyelin leukodystrophi character hypomyelin hypodontia hypogonadotrop hypogonad date one studi report demyelin peripher neuropathi phenotyp caus heterozyg polrb variant | D002607 | T047 |
34,666,704 | implement colorect cancer screen intervent low middl incom countri scope review low middl incom countri lmic experienc increas rate colorect cancer crc incid last decad lower year surviv rate compar high incom countri hic implement screen treatment servic advanc review scope map literatur regard content implement uptak crc screen intervent well opportun challeng implement crc screen intervent lmic | D058070;D003906 | T080;T047 |
34,666,702 | find common research ground general practition neuroscientist vital role knowledg circul close evid practic gap may take year longer research evid integr clinic practic evid practic gap deleteri effect patient well research clinic process bring clinic knowledg research process howev potenti close evid practic gap neurotran project attempt bring research practic togeth focus two group usual oper separ communiti general practition neuroscientist although group focus dementia area work differ context without opportun share expertis find new treatment pathway patient dementia requir equal knowledg exchang among research clinician along integr knowledg research process group benefit expertis | D058005 | T097 |
34,666,699 | impact organiz context patient outcom proactiv primari care program longitudin observ studi effect health care intervent co determin contextu factor unknown extent impact patient outcom therefor aim studi explor characterist general practic associ patient outcom proactiv primari care program u profit | D000073496;D058006;D058005 | T184;T097;T046;T091;T033 |
34,666,698 | recurr primari pyogen ventricul adult woman case report recurr primari pyogen ventricul report previous present uniqu case recurr primari pyogen ventricul adult believ studi make signific contribut literatur | D058565;D004660 | T047 |
34,666,697 | postpartum opportunist advic primari care women gestat diabet qualit studi health care profession view women gestat diabet pregnanc high risk develop type diabet later life understand risk often limit studi explor view health care profession regard offer brief opportunist advic women pregnanc unrel consult primari care relat reduc diabet risk | D003924;D016640 | T047 |
34,666,696 | predictor fear childbirth depress symptom among pregnant women cross section survey pwani region tanzania mani women experi fear childbirth fob depress symptom ds pregnanc littl known fob among tanzanian women current studi aim assess preval fob ds among pregnant women determin predictor focus sociodemograph obstetr predictor | D005239 | T041 |
34,666,695 | reduc mortal kpc kpneumonia bloodstream infect high risk patient hematolog malign colon kpc kpneumonia kpc kpneumonia bloodstream infect kpc kpbsi mortal rate patient hematolog malign report initi treatment activ kpc kpneumonia crucial surviv kpc kpneumonia rectal colon usual preced kpc kpbsi evalu impact kpc kpbsi mortal preemptiv use antibiot activ kpc kpneumonia oppos inact standard empir antibiot empir treatment febril neutropenia episod patient hematolog malign identifi kpc kpneumonia intestin carrier | D016470;D019337;D007710 | T191;T047 |
34,666,694 | preoper albi grade predict outcom non b non c hcc patient undergo primari curat resect albumin bilirubin albi grade valid signific prognost predictor hepatocellular carcinoma hcc howev littl inform albi grade patient non b non c hcc nbnc hcc receiv surgeri | D006528;D008113 | T191 |
34,666,693 | effect ultraviolet irradi compar oral vitamin supplement blood pressur nurs home resid dementia observ studi report invers associ ultraviolet uv radiat hypertens aim studi assess differ blood pressur chang person dementia receiv uv light versus vitamin vd supplement | D003704;D014807 | T048;T127;T121 |
34,666,692 | global dengu import systemat review import dengu follow global present emerg threat global health howev evid global geograph sourc potenti dengu import global lack studi aim systemat review sourc dengu import global risk dengu outbreak global | D000330;D003715 | T204;T047 |
34,666,691 | manag preoper pain elder patient moder sever cognit deficit hip fractur retrospect monocentr studi orthogeriatr unit patient cognit deficit time like suffer hip fractur geriatr patient age group without cognit deficit persist periop pain follow hip fractur risk factor occurr delirium poor function prognosi develop secondari chronic pain patient cognit deficit receiv less analges without cognit deficit retrospect descript monocentr studi perform orthogeriatr unit cohort elder patient hospit hip fractur aim studi compar quantiti strong opioid deliv morphin sulfat equival daili preoper period hip fractur cognit intact patient cognit deficit | D006620 | T037 |
34,666,690 | predict abil g screen test determin probabl sarcopenia abnorm comprehens geriatr assess older patient solid malign pre treatment evalu sarcopenia recommend cancer patient new screen test less time consum identifi patient potenti benefit geriatr assess develop g geriatr screen test one exampl aim investig whether g screen test detect probabl sarcopenia valid reliabl compar comprehens geriatr assess cga turkish older adult solid cancer | D009369;D055948 | T191;T047 |
34,666,689 | anti hypertens drug deprescrib updat systemat review clinic trial polypharmaci defin prescript least differ medicin therapeut prophylact effect serious issu among elder patient frequent affect multi morbid deprescrib one propos approach reduc number administ drug elimin inappropri prescrib aim systemat review provid updat systemat assess benefit risk profil deprescrib anti hypertens drug among common use drug | D000959;D000069340 | T058;T170;T121 |
34,666,688 | test central sensit general practic delphi studi central sensit cs may explain persist symptom patient chronic pain persist physic symptom pps need assess cs consult room recent publish systemat review made inventori test cs studi aim assess test might ad valu might feasibl thus suitabl use general practic | D059350;D058006 | T091;T047;T184 |
34,666,687 | anesthet manag cesarean deliveri women placenta previa retrospect cohort studi incid placenta preiva rise cesarean deliveri identifi safe appropri mode deliveri pregnanc placenta previa anesthesia import cesarean deliveri aim studi assess matern neonat outcom patient placenta previa manag neuraxi anesthesia compar underw general anesthesia cesarean deliveri | D000768;D000775;D002585 | T079;T061 |
34,666,686 | effect mobil phone messag patient health worker knowledg adher isoniazid prevent therapi guidelin hiv clinic southeast nigeria hiv infect person increas risk develop tuberculosi isoniazid prevent therapi shown reduc occurr tuberculosi among group person health technolog report increas knowledg implement various health servic includ isoniazid prevent therapi implement studi aim determin effect health health worker knowledg adher isoniazid prevent therapi ipt guidelin patient knowledg adher isoniazid treatment | D040421;D015658;D014376 | T047;T073 |
34,666,685 | efficaci macrogol plus electrolyt bowel prepar colonoscopi patient chronic constip chronic constip signific factor poor bowel prepar colonoscopi macrogol plus electrolyt movicol ea pharma tokyo japan contain polyethylen glycol peg electrolyt use recent treat patient constip howev prospect studi use macrogol bowel cleans colonoscopi lack studi aim investig efficaci safeti macrogol addit peg administ patient chronic constip | D002432;D003113 | T061;T023;T060 |
34,666,684 | identif predict development enhanc sea urchin embryo transcript development regulatori gene often control multipl cis regulatori element identif function character distal regulatori element remain challeng even tractabl model organ like sea urchin | D018507;D012045 | T114;T045;T123 |
34,666,683 | humor cellular respons sar cov bntb mrna vaccin hemodialysi patient hemodialysi hd patient increas risk acquir infect due mani health care contact may addit suboptim respons vaccin high mortal covid infect | D006435 | T061 |
34,666,682 | challeng vision manag pain relat insomnia primari care use hybrid cbt approach small scale qualit interview studi gps nurs practic manag chronic pain insomnia complex bidirect relationship address sleep complaint alongsid pain may key allevi patient report distress disabl healthcar profession consist report want offer psycholog inform chronic pain manag primari care level research secondari care demonstr good treatment efficaci hybrid cbt chronic pain insomnia howev primari care typic main point treatment entri henc may better situat offer treatment use multidisciplinari approach studi primari care servic provid percept feasibl tackl pain relat insomnia primari care explor | D059350;D009726;D007319 | T097;T048;T047;T184 |
34,666,681 | trial registr select outcom report clinic trial investig drug prevent postop nausea vomit select outcom report clinic trial introduc bias bodi evid distort clinic decis make trial registr aim prevent bias suggest intern committe medic journal editor icmj sinc | D000079204;D012042 | T170;T064 |
34,666,680 | corescd multi stakehold consensus core outcom sickl cell diseas clinic trial dramat increas pipelin new sickl cell diseas scd therapi recent year time ripe ensur robust bodi evid avail decis make regul payer clinician patient harmon outcom select across intervent trial enabl optim post trial apprais decis make valid pool analys indirect comparison employ structur multi stakehold consensus process develop core outcom set cos use clinic trial scd intervent | D000755;D011788 | T047;T078 |
34,666,678 | optimis person continu older patient general practic studi protocol cluster randomis step wedg pragmat trial continu care particular person continu core principl general practic associ mani benefit better patient provid relationship lower mortal howev person continu pressur due chang societi healthcar affect older patient younger patient number older patient doubl come decad intervent optimis person continu group high warrant | D058006;D058005 | T091;T097 |
34,666,677 | improv detect diseas associ gut microb use sequenc base biomark sequenc partial rrna gene cost effect method quantifi microbi composit environ human gut howev downstream analysi reli bin read microbi group either consid uniqu sequenc differ microb queri databas get taxonom label sequenc cluster similar sequenc togeth howev approach fulli captur evolutionari relationship microb limit abil identifi differenti abund group microb diseas control cohort present sequenc base biomark sbbs aggreg method group aggreg microb use singl variant combin variant within sequenc compar sbbs exist aggreg method otu cluster microphenoor ditaxa featur sever benchmark task biomark discoveri via permut test biomark discoveri via linear discrimin analysi phenotyp predict power demonstr sbbs perform par better state art method biomark discoveri phenotyp predict | D000069196 | T007;T001 |
34,666,676 | conserv breed specif differ cervic transcriptom sheep diverg fertil follicular phase natur oestrus cycl outcom cervic artifici insemin ai frozen thaw semen sheep limit inabl sperm travers cervix ewe breed previous research demonstr cervic sperm transport depend ewe breed sperm travers cervix greater number higher fertil ewe breed howev molecular mechan under ewe breed differ sperm transport cervix remain unknown studi aim characteris cervic transcriptom four european ewe breed known differ pregnanc rate follow cervic ai use frozen thaw semen follicular phase natur oestrous cycl cervic post mortem tissu sampl collect two irish ewe breed belclar suffolk medium low fertil respect two norwegian ewe breed norwegian white sheep nws fur high fertil compar irish breed follicular phase natur oestrous cycl n ewe per breed | D002584;D005498 | T023;T079 |
34,666,675 | transcriptom analysi clavibact michiganensi subsp michiganensi infect tomato role salicyl acid host respons bacteri canker tomato solanum lycopersicon caus gram posit bacterium clavibact michiganensi subsp michiganensi cmm econom import diseas understand host defens respons cmm infect transcriptom sequenc tomato cotyledon analyz rna seq overal gene upregul downregul upon infect respect gene ontolog enrich analysi reveal gene involv defens respons phosphoryl hormon signal repres infect induc express defens associ gene suggest tomato respons cmm show similar common plant diseas respons infect mani resist gene analog rgas transcript upregul includ express receptor like kinas rlks involv pattern trigger immun express wrkys nac hsfs cbps encod transcript factor tfs report regul defens associ gene induc infect cmm tomato gene ortholog arabidopsi ed edssid pade causal gene salicyl acid sa defici mutant upregul infect cmm furthermor cmm infect drastic stimul sa accumul tomato cotyledon gene involv phenylalanin ammonia lyas pathway upregul wherea metabol enzym gene express isochorism synthas pathway remain unchang exogen appli sa suppress bacteri growth induc express wrkys suggest cmm respons gene regul sa signal sa signal activ improv tomato immun cmm | D054884;D059467 | T040;T086;T081 |
34,666,673 | effect age sugammadex revers neuromuscular blockad induc rocuronium chines children prospect pilot trial sugammadex revers neuromuscular blockad induc steroid relax compar recoveri neuromuscular blockad revers sugammadex children age year | D019148 | T061 |
34,666,672 | long noncod rna mapkapk promot lipopolysaccharid induc inflammatori damag myocardium spong microrna pef myocardi dysfunct caus sepsi simd lead high mortal critic ill patient investig function mechan long non code rna mapkapk lncrna mapkapk lipopolysaccharid lps induc inflamm respons vivo vitro | D005786 | T045 |
34,666,671 | oxid stress indic asd children sub sahara africa pathogenesi autism spectrum disord asd remain medic challeng even develop world although genet epigenet factor various indict major caus disord develop oxid stress especi format year children equal gain promin etiolog basi disord oxid stress character product excess amount free radic decreas level antioxid attend imbal oxidantantioxid ratio studi design determin level essenti metal magnesium mg zinc zn copper cu toxic metal lead pb generat oxid stress abnorm interact | D000067877 | T048 |
34,666,670 | hsp regul pd l promot hpv posit cervic cancer via herpikakt pathway hpv predomin cancer caus strain respons cervic cancer studi aim investig therapeut effect heat shock protein hsp knockdown hpv cervic cancer progress under mechan | D015972 | T045 |
34,666,669 | clinic symptom androgen defici men migrain cluster headach cross section cohort studi compar symptom clinic androgen defici men migrain men cluster headach non headach male control | D003027;D008881 | T047 |
34,666,667 | two case rhino orbito cerebr mucormicosi develop covid infect coronavirus covid infect caus excess cytokin respons decreas cellular immun respons increas suscept fungal co infect mucormycosi rare lifethreaten invas fungal infect report two case develop rhino orbito cerebr mucormycosi short covid infect present first case year old woman admit clinic orbit cellul left eye known diagnosi asthma rheumatoid arthriti diagnos covid pneumonia day ago stay intens care unit long time receiv puls steroid mg methylprednisolon interleukin il inhibitor anakinra broad spectrum antibiot treatment togeth antivir therapi period second case year old male patient known diabet mellitus hypertens retin pigmentosa histori hospit intens care unit due covid pneumonia day ago receiv puls steroid therapi period admit clinic complaint droopi right eyelid swell nausea vomit case paranas sinus tomographi find consist invas sinus function endoscop sinus surgeri perform immedi less hour first admiss case histopatholog examin case reveal result consist mucormycosi mucoral spp isol sinus tissu cultur second case taken oper patient receiv liposom amphotericin b first case die th day treatment second case discharg full recoveri nine week treatment suppress cellular immun covid infect use steroid interleukin inhibitor treatment sever case may increas secondari invas fungal infect therefor clinician frequent consid possibl fungal infect patient covid | D000086382;D015821;D009916 | T047;T067 |
34,666,666 | case periton caus wickerhamomyc anomalus candida pelliculosa relat periton dialysi fungal periton less common seen bacteri periton patient undergo periton dialysi pd serious complic high morbid mortal often result cathet loss modifi therapi pd hemodialysi causat organ often candida speci report pd associ periton caus wickerhamomyc anomalus candida pelliculosa rare fungal infect agent increas clinic import caus differ clinic pictur present outpati periton fluid cultur sent yearold male patient undergo continu periton dialysi capd year due abdomin pain blur periton fluid dialysi patient admit emerg depart four day later due persist complaint sampl periton fluid taken emerg depart sent laboratori microbiolog analysi direct microscop examin periton fluid cell number determin mm microorgan seen gram methylen blue stain patient admit nephrolog servic pre diagnosi pd associ periton enterobact aerogen grown periton fluid cultur sent dialysi outpati clinic four day ago periton fluid sampl sent emerg depart inocul sheep blood emb chocol agar growth detect patient complaint periton fluid leukocyt count continu increas periton fluid cultur repeat recurr growth yeast detect cultur yeast identifi candida pelliculosa matrix assist laser desorpt ionize time flight mass spectrofotometri maldi tof vitekm biomerieux franc speci identif confirm sequenc target gene region rrna isol identifi wickerhamomyc anomalus sexual reproduct form candida pelliculosa teleomorph refer microdilut method perform accord recommend clinic laboratori standard institut clsi order test antifung suscept hour incub minim inhibitori concentr mic determin gml amphotericin b gml caspofungin gml voriconazol g ml itraconazol gml fluconazol fluconazol anidulafungin start treatment fungal periton patient periton dialysi cathet remov hemodialysi appli patient clinic laboratori symptom regress antifung therapi patient anidulafungin treatment discontinu day cathet remov conclus patient undergo capd case fungal pathogen also consid although rare laboratori clinic improv respons treatment complet pd associ periton prevent delay diagnosi treatment | D010530;D010538 | T047;T061;T046 |
34,666,665 | card mutat patient candida albican meningoenceph case report primari immunodefici disord caus clinic find rang mild diseas life threaten diseas wide age rang infect common complic primari immunodefici caspas associ recruit domain card protein play role fungal immun respons card defici one primari immunodefici disord show autosom recess inherit caus differ clinic pictur associ various fungal infect superfici deep dermatophytosi invas pheohifomycosi cutan mucormycosi extrapulmonari aspergillosi mucocutan invas candidiasi common infect card defici caus candida spp report case candida albican meningoenceph due card defici present learn medic stori year old male patient known diseas drug use recurr oral candidiasi cutan fungal infect sinc childhood receiv liposom amphotericin b treatment diagnosi calbican meningoenceph two month ago learn discharg voriconazol treatment clinic improv stop voriconazol treatment discharg go follow patient reappli month discharg complaint headach vomit alter conscious fever neck stiff kern bruzinski sign negat extern ventricular drainag evd cathet insert hydrocephalus detect brain computer tomographi ct cerebrospin fluid csf examin erythrocyt count detect mm leukocyt seen csf protein level mgdl csf glucos level mgdl simultan blood glucos level mgdl yeast bacteria csf gram stain acidfast bacteria ziehl neelsen stain learn growth mycobacterium tuberculosi cultur made csf sampl taken first admiss patient serum human immunodefici virus antibodi negat upon learn fluconazol suscept calbican growth control csf cultur patient evd cathet chang liposom amphotericin b treatment start csf cultur repeat fluconazol suscept calbican continu grow csf cultur repeat follow up patholog favor abscess detect brain magnet reson imag fluconazol ad current liposom amphotericin b treatment histori recurr mucocutan fungal infect patient sibl whose parent third degre relat suggest card defici molecular test studi blood sampl homozyg pqx mutat due card defici detect patient sister howev patient die nd day hospit due delay diagnosi cerebr complic due recurr calbican meningoenceph insuffici treatment result failur receiv granulocyt coloni stimul factor g csf treatment persist fungal infect develop card defici caus serious complic mortal consid frequenc card defici turkish popul lack diagnost test countri thought may mani patient diagnos progress mortal morbid conclus case present emphas consider card defici case persist invas fungal infect recurr invas fungal infect treatment despit effect antifung treatment children adult known risk factor invas fungal infect | D058365;D008590 | T047 |
34,666,664 | first case covid posit candida auri fungemia turkey candida auri speci fungus gain import recent year owe abil caus hospit infect epidem resist antifung agent disinfect process frequent misidentifi commerci system hospit outbreak caus cauri report countri determin cauri lower virul candida albican howev associ high mortal rate immunocompromis individu increas incid invas fungal infect lead serious complic death identifi sever coronavirus covid patient immunocompromis individu under diseas studi demonstr increas frequenc cauri isol covid patient candidemia report first case covid posit cauri fungemia detect turkey present year old male patient histori myocardi infarct diabet mellitus donat singl kidney lobectomi surgeri due lung cancer hospit pandem thorac surgeri servic due find consist viral pneumonia thorac comput tomographi favipiravir x mg intraven dexamethason x mg therapi administ patient test posit sar cov polymeras chain reaction sever involv left lung detect follow day antibiot administ follow insert right jugular vein cathet init tocilizumab patient transfer intens care unit due increas respiratori distress yeast growth detect patient hemocultur yeast strain could identifi use api id c biomerieux franc sacchromyc kluyveri candida sake unaccept profil identifi cauri use vitek maldi tof ms biomerieux franc system confirm sequenc minimum inhibitor concentr valu detect gml amphotericin b gml fluconazol gml voriconazol gml itraconazol gml posaconazol gml caspofungin gml anidulafungin use antibiot gradient method patient initi treatment compris meropenem x g vancomycin x g caspofungin x mg continu caspofungin x mg load dose vancomycin x g hour third day treatment patient die ninth day develop candidemia present case first case fungemia caus cauri covid posit patient turkey emphas need caution fungemia due cauri intens care unit countri high covid incid | D000086382;D058387;D016469 | T047;T067 |
34,666,663 | case chronic q fever endocard mimick lymphoprolif disord q fever zoonosi caus coxiella burnetii report case chronic q fever endocard pancytopenia hypergammaglobulinemia mimick lymphoprolif diseas present year old male live atalca whose famili engag anim husbandri admit complaint weak fatigu patient aortic valv replac year ago aortic valv replac ascend aorta graft endocard three year ago reveal second oper patient due possibl infect endocard definit agent could identifi evalu massiv hepatosplenomegali pancytopenia hypergammaglobulinemia presenc spike elev microglobulin level refer hematolog clinic preliminari diagnosi lymphoprolif diseas lymphoplasmacyt lymphoma exclud result bone marrow biopsi refer clinic investig possibl infecti etiolog detect hepatosplenomegali finger club blood analys normal except follow leukocyt count l platelet count l gamma globulin grdl rheumatoid factor rf antinuclear antibodi ana posit chronic q fever endocard suspect cburnetii phase igg test found posit titer although transesophag echocardiographi show lesion endocard positron emiss tomographycomput tomographi reveal increas fluorodeoxyglucos uptak around prosthet heart valv graft patient diagnos q fever endocard graft infect refus hospit start hydroxychloroquin doxycyclin treatment patient stop take antibiot seven day diagnosi admit headach anoth hospit oper intracrani hemorrhag die short apart unfamiliar wide rang clinic present diseas could also lead delay diagnosi among patient chronic q fever continu bacteremia antigen stimulus caus inflammatori syndrom hepatosplenomegali hypergammaglobulinemia presenc autoantibodi lead misdiagnos rheumatolog autoimmun hematolog diseas chronic q fever investig patient known valvulopathi chronic hepatomegali splenomegali pancytopenia hypergammaglobulinemia unexplain autoantibodi posit | D016997;D004696;D004697;D008232;D011778 | T191;T007;T047 |
34,666,662 | vitro efficaci venom black scorpion androctonus crassicauda leishmania tropica promastigot scorpion venom substanc show strong neurotox effect complex protein content thus play import role scorpion catch digest hunt human bodi stung scorpion show life threaten system effect short time rang erythema pain edema local fever abdomin pain nausea vomit diplopia even coma scorpion venom known possess antimicrobi activ compound potent antibacteri antifung activ leishmaniasi common vector born parasit infect caus leishmania sp protozoa lead skin mucosa fatal intern organ involv patient need new drug treatment leishmaniasi document late grow resist antimoni compound use treatment decad leishmania speci known suscept antimicrobi peptid act ion channel inhibitor known present scorpion venom studi aim investig anti leishmani activ scorpion venom extract obtain androctonus crassicauda speci countri context leishmania tropica promastigot thaw liquid nitrogen laboratori first grown nnn rpmi media expos differ dilut extract contain acrassicauda venom meglumin antimon use standard treatment leishmaniasi efficaci promastigot compar measur vitro follow xtt cell viabil test assess whether anti leishmani dose extract lethal human cell trial show half maxim inhibitori concentr ic valu venom extract meglumin antimoni gml gml respect preliminari studi show scorpion venom lethal ltropica promastigot vitro relat higher dose compar meglumin antimon next step determin anti leishmani protein extract thus identifi new drug candid specif studi | D000981;D007895;D007896 | T204;T047;T121 |
34,666,661 | evalu eucast direct rapid antimicrobi suscept test method blood cultur bottl posit signal earli report antibiot suscept test ast result essenti surviv sepsi patient european committe antimicrobi suscept test eucast publish propos detect antimicrobi suscept posit blood cultur bottl rapid antimicrobi suscept test rast method maximum eight hour studi aim evalu eucast rast method blood cultur bottl result posit signal bactalert biomrieux franc blood cultur system show gram negat bacteria singl morpholog gram stain studi conduct prospect april novemb nineti blood cultur bottl detect singl gram negat bacteria morpholog gram stain test accord eucast rast method isol obtain blood cultur bottl studi eucast disk diffus method vitek compact biomerieux franc autom system result obtain rast compar result method turn around time rast method record categor agreement rast method convent method major error rate determin isol yet cover eucast hadt method determin enterobacteral member two non ferment two isol detect morpholog characterist gram stain blood cultur bottl antibiot suscept profil differ identif result sixteen isol exclud studi studi suscept isol determin accord eucast breakpoint tabl klebsiella pneumonia escherichia coli four acinetobact baumannii four pseudomona aeruginosa accord evalu period eucast rast suscept profil report nine ecoli four hour eight six hour eight hour three kpneumonia four hour six hour eight hour three paeruginosa six hour one eight hour two abaumannii six hour two eight hour categor aggrement rast method autom system disc diffus method major error rast method compar autom system detect piperacillin tazobactam ceftazidim meropenem compar disc diffus method cefotaxim meropenem result shown eucast rast method practicali perform routin laboratori report earli result low cost major error necessari confirm result standard method | D000890;D000071997 | T121;T059 |
34,666,660 | investig fosfomycin suscept extend spectrum beta lactamas produc enter bacteria disk diffus autom system agar diltion kit due increas bacteria develop resist classic antibiot recent year fosfomycin becom one antibiot gain import fosfomycin exert bactericid effect mani bacteria bind cytoplasm enzym mura inhibit enzym enopurivil transferas involv peptidoglycan synthesi bacteria produc esbl common pathogen nosocomi infect resist frequent encount treatment fosfomycin consid altern drug infect reintroduct import establish reliabl reproduc suscept test method fosfomycin studi aim evalu util disk diffus agar dilut kit autom microscan method beckman coulter brea ca abd fosfomycin suscept esbl produc enter bacteria studi includ esbl posit isol enter bacteria escherichia coli klebsiella pneumonia cultiv sampl sent microbiolog laboratori mersin univers medic faculti medicin hospit may novemb fosfomycin suscept isol includ studi test disk diffus autom microscan commerci agar dilut kit studi isol determin resist fosfomycin disk diffus method six isol found resist fosfomycin microscan automat system agar dilut kit isol found resist minimum inhibitori concentr mic valu gml fosfomycin resist signific higher kpneumonia isol ecoli isol agar dilut method p ertapenem resist detect seven isol seven isol resist ertapenem suscept fosfomycin agar dilut method three isol found resist colistin suscept fosfomycin agar dilut method studi categor agreement disk diffus microscan method ecoli isol agar dilut high error rate low kpneumonia categor concord calcul disk diffus test microscan major minor error rate found quit high result fosfomycin thought altern drug option treatment infect caus especi carbapenem colistin resist bacteria high activ esbl produc enter bacteria determin great agreement agar dilut refer method determin fosfomycin resist ecoli microscan disk diffus method disk diffus method provid eas use term cost labor compar agar dilut method use reliabl method howev demonstr agar dilut method use kpneumonia isol nevertheless conclud automat system use laboratori agar dilut perform result interpret care sinc error rate high | D005578;D000069196 | T195;T007;T001;T109 |
34,666,659 | follow treatment process malaria real time polymeras chain reaction vivo model microscop method accept gold standard diagnosi malaria followup treatment howev microscop method requir experienc personnel import confirm diagnosi differ method accur diagnosi treatment follow studi aim investig util use real time revers transcriptas polymeras chain reaction rrt pcr well microscop method malaria treatment follow studi form five group consist five male balbc mice mous inject intraperiton ml plasmodium berghei parasit hour follow inject mice first second third group receiv mgkgday chloroquin treatment one two three day respect fourth group treat fifth group mice receiv salin three day parasitemia monitor day blood smear prepar end tail mice search presenc target gene region parasit rrt pcr blood smear rrt pcr result posit group ii iv v blood smear rrt pcr result mice group third group found posit blood smear mice third group found posit th th day infect subsequ prepar evalu negat rrt pcr result show posit day seven presenc target gene region parasit detect day comparison microscopi rrt pcr method shown parallel result apart microscop examin method conclud rrt pcr method import diagnosi malaria follow patient treatment process differ method support use | D008288 | T047 |
34,666,658 | flow cytometri optim three differ bodipi molecul stain lipid droplet cryptococcus neoforman pathogen cryptococcus neoforman caus life threaten diseas immunocompromis patient although hypothes role lipid droplet cneoforman pathogenesi still extens data determin subject yet lipid droplet dynam cytoplasm energi storag bodi yeast diazo dye nile red ld borradiazaindasen bodipi molecul frequent use lipid droplet studi bodipi difluoro bora aa diaza indacen dyestuff among brightest green light emit fluorophor neutral molecul high lipophil easili pass cell wall membran studi futur studi lipid droplet cneoforman aim optim three differ bodipi bodipi bodipi bodipi molecul fluoresc microscopi flow cytometri system ten molecular confirm environment cneoforman strain grown sabouraud dextros agar without oleic acid bodipi stain protocol differ concentr use cneoforman lipid droplet fix paraformaldehyd visual fluoresc microscopi detect flow cytomet lipid droplet structur cneoforman strain evalu forwardscatt side scatter analysi perform evalu number lipid droplet determin cytoplasm region quadrant flow cytometri stain lipid droplet cneoforman three bodipi molecul use studi observ fluoresc microscop creat distinct bright sharp contrast background bodipi molecul could examin fluoresc microscopi without loss bright one minut optim dye concentr bodipi compound found incub room temperatur five minut suffici fluorochrom stain also shown abl stain lipid droplet heatinactiv cneoforman strain three compound synthes bodipi bodipi bodipi molecul evalu accord stain lipid droplet claim play role pathogenesi cneoforman analysi fluoresc microscopi analysi flow cytomet bodipi molecul may exhibit differ properti stain lipid droplet molecul test demonstr presenc lipid droplet differ yeast speci suitabl pathogenesi studi | D003455 | T004 |
34,666,657 | mortal risk factor invas candidiasi pediatr intens care unit invas candida infect one import risk factor increas mortal immunocompromis patient comorbid intens care unit studi aim evalu mortal rate risk factor affect mortal patient follow diagnosi invas candidiasi pediatr intens care unit patient age month year follow paediatr intens care unit invas candidiasi includ studi demograph characterist patient fever hypotens candida speci use broad spectrum antibiot blood transfus parenter nutrit invas intervent use mechan ventil laboratori test result retrospect analyz relationship mortal statist determin total patient girl boy includ studi death rate n candida albican common speci isol follow candida parapsilosi candida tropicali other statist signific relationship detect central venous cathet broad spectrum antibiot corticosteroid treatment parenter nutrit gender differ surgic oper patient cultur sampl isol candida speci mortal p statist signific relationship found blood transfus thrombocytopenia leukopenia first posit cultur time sinc hospit durat antibiot treatment mortal p statist signific correl found presenc hypotens one clinic marker associ mortal p mortal rate high candidiasi patient pediatr intens care unit blood transfus long term use broad spectrum antibiot hypotens increas mortal | D058365 | T047 |
34,666,656 | comparison candida polymeras chain reaction method blood cultur patient high risk candidemia intens care unit candida speci respons invas fungal infect intens care unit earli diagnosi treatment import candidemia improp diagnosi treatment increas mortal morbid signific late result blood cultur low sensit serolog test use alon molecular method investig field studi result candida real time polymeras chain reaction rt pcr test studi blood cultur whole blood compar patient high candidemia risk follow general surgeri intens care anesthesiolog reanim unit cukurova univers faculti medicin aim investig practic util candida rt pcr test rapid diagnosi method patient suspect candidemia studi patient high risk candidemia accord criteria determin accord guidelin evalu prospect urin perineum axilla tracheal aspir cultur two set blood cultur obtain patient blood sampl also drawn ethylenediaminetetraacet acid edta tube store c later candida rt pcr studi candida rt pcr speci specif primer use distinguish speci candida score cs patient calcul forti one patient femal male median age patient year candida posit blood cultur three patient includ studi candida rt pcr posit candida speci detect blood cultur rt pcr test compat rt pcr signific posit p candida rt pcr posit signific higher patient receiv total parenter nutrit p malign p histori surgeri last three month p differ cs patient pcr posit pcr negat statist signific p studi conduct high risk popul candidemia result candida rt pcr found posit blood cultur rt pcr posit blood cultur posit associ high cs light data thought would appropri use molecular method diagnosi support cs especi patient high risk candidemia consid blood cultur gold standard diagnosi candidemia give late result posit use faster diagnost method candidemia import reduc mortal morbid fast good result candida pcr method shown use diagnosi howev lack standard primer use pcr test may caus fals posit addit studi need respect | D000071997;D058387 | T047;T059 |
34,666,655 | investig group rotavirus g g genotyp emerg patient acut gastroenter tertiari care hospit rotavirus common caus viral gastroenter highest mortal morbid rate children age year aim studi determin frequenc rotavirus infect patient whose stool sampl sent microbiolog laboratori investig etiolog diarrhea investig rotavirus genotyp common region g g genotyp recent becom common world fecal sampl patient age year appli novemb februari studi via immunochromatograph rapid test enzym link immunosorb assay elisa method elisa posit sampl studi nest revers transcriptas chain reaction rt pcr genotyp agaros gel electrophoresi rotavirus found posit stool sampl immunochromatograph test elisa respect elisa posit sampl also detect posit rt pcr femal patient male patient found posit rotavirus posit statist signific gender frequenc rotavirus differ age group year month month determin rotavirus case common spring g g g g g g g detect sampl respect g common genotyp g common g p genotyp combin gp follow gp gp p found domin p genotyp studi observ rotavirus caus childhood diarrhea also encount advanc age even new genotyp infect human worldwid may also causat agent therefor conclud import investig new genotyp g g molecular epidemiolog studi | D005759;D012401;D012400 | T047;T005 |
34,666,654 | investig relationship system immun inflamm index c reactiv protein interleukin viral dynam patient covid coronavirus envelop positivepolar singl strand rna virus caus respiratori gastrointestin tract infect less like caus infect hepat neurolog nephrot involv novel coronavirus term sever acut respiratori syndrom coronavirus sar cov emerg citi wuhan china caus outbreak unusu viral pneumonia end studi aim reveal relationship system immun inflamm index sii c reactiv protein crp interleukin il viral dynam covid patient retrospect singl center studi conduct ankara citi hospit april may total hospit patient posit result sar cov revers transcrytas polymeras chain reaction rt pcr test nasopharyng oropharyng sampl hospit admiss includ studi patient divid three group accord wardintens care unit intub mortal situat clinic data evalu correl analysi perform determin relationship viral dynam laboratori paramet sii neutrophil lymphocyt ratio nlr lymphocyt crp ratio lcr lymphocyt monocyt ratio lmr platelet lymphocyt ratio plr crp il ferritin albumin level lymphocyt count advanc age low ct valu increas il increas sii decreas albumin increas ferritin decreas lymphocyt count increas nlr decreas lcr decreas lmr increas plr increas crp level found statist signific differ three group p p p p p p p p p p p p respect statist analysi reveal signific negat correl serum il nlr lcr crp valu ct valu p r p r p r p r respect signific posit correl ct valu lymphocyt count albumin level p r p r respect sever progress observ patient advanc age low ct valu high il level high sii hypoalbuminemia high ferritin level lymphopenia high nlr low lcr low lmr high plr high crp patient hospit intens care unit intub mortal found higher high level il nlr lcr crp lymphopenia hypoalbuminemia associ low pcr ct valu | D002097;D000086382;D015850 | T129;T047;T116;T067 |
34,666,653 | factor affect side effect seroconvers rate antibodi respons inactiv sar cov vaccin healthcar worker studi aim prospect evalu efficaci side effect seroconvers data inact sever acut respiratori syndrom coronavirus sar cov coronavac sinovac china vaccin healthcar worker total healthcar worker initi seroneg covt sar cov total siemen usa vaccin inactiv sar cov includ studi quantit igg antibodi advia centaur sar cov igg siemen usa investig day first vaccin n second vaccin n addit neutral antibodi evalu via enzym link immunosorb assay elisa test ace rbd neutral assay dia pro itali day first vaccin antibodi respons vaccin evalu statist univari chi squar fisher exact test student test mann whitney u one way anova kruskal walli anova test analysi linear regress model consist quantit igg test neutral antibodi test also evalu blood sampl taken day second vaccin statist analysi determin logarithm transform data statist analysi spss stata type error level accept least one side effect report particip first second vaccin respect frequent side effect pain inject site frequenc vs frequenc appli health center due side effect first vaccin second vaccin percentag produc suffici quantit igg found ci day first vaccin ci second vaccin neutral test antibodi posit found day second vaccin univari analysi characterist signific increas quantit igg respons inactiv sar cov vaccin young age p femal gender p non smoker p chronic diseas p flu vaccin year p overweight obes p sar cov infect prior vaccin p addit alli health personnel show signific lower antibodi respons worker p multipl linear regress model reveal femal gender younger age smoke previous covid polymeras chain reaction test posit signific affect quantit igg respons vaccin agreement found elisa base neutral antibodi test quantit igg test kappa p perform th day second vaccin coronavac provid adequ antibodi respons healthcar worker age day singl vaccin day second vaccin antibodi respons signific higher younger age women non smoker previous encount sar cov phase phase result need show effect vaccin real life | D000086382;D000086663 | T047;T200;T067 |
34,666,651 | burden pneumococc mening bacteremia serotyp distribut antibiot resist healthi children conjug pneumococc vaccin implement singl center experi turkey seven valent pneumococc conjug vaccin pcv includ childhood nation immun programm april replac valent pneumococc conjug vaccin pcv april retrospect singl center studi aim determin serotyp distribut antimicrobi resist streptococcus pneumonia isol pediatr patient invas pneumococc diseas ipd introduct pvc pvc fifti pediatr patient diagnos mening sepsisbacteremia octob octob includ studi pediatr patient group consist previous healthi patient diagnos mening sepsisbacteremia spneumonia isol blood cerebrospin fluid patient pneumonia associ bacteremia empyema includ studi serotyp isol perform quellung reaction use specif antisera staten serum institut denmark antibiot penicillin ceftriaxon suscept determin antibiot gradient method base clinic laboratori standard institut clsi criteria children boy girl median age patient month month year children age five evalu found patient diagnos occult bacteremiasepsi mening overal annual incid rate ipd among healthi children age year decreas signific p common serotyp detect isol f f f b accord minimum inhibitori concentr valu isol recov patient mening penicillin ceftriaxon resist rate found respect conclus studi show decreas incid ipd healthi children age five year implement pcv pcv determin rate serotyp vaccin content decreas increas non vaccin serotyp addit signific chang observ antibiot resist rate year | D016470;D008586;D011008 | T047;T050 |
34,666,650 | investig azithromycin minimum inhibitori concentr valu carbapenem resist salmonella shigella clinic isol increas resist first line antibiot use treatment infect caus salmonella shigella speci emerg azithromycin present good altern treatment option salmonella shigella infect howev limit data regard suscept azithromycin turkey studi aim evalu suscept salmonella shigella speci azithromycin determin compar minimum inhibitori concentr mic valu disk diffus zone diamet addit suscept meropenem first line antibiot option isol also investig total salmonella shigella clinic isol collect hospit test suscept azithromycin meropenem ampicillin pefloxacin trimetoprim sulfamethoxazol ceftazidim cefotaxim isol identifi matrix assist laser desorpt ionize time flight mass spectrometri isol confirm serotyp refer laboratori use convent slide agglutin method suscept isol azithromycin antibiot evalu kirbi bauer disk diffus method mic valu azithromycin determin refer broth microdilut method combin disk diffus test use detect extend spectrum beta lactamas esbl product polymeras chain reaction perform macrolid carbapenem resist gene detect resist gene confirm sequenc shigella isol test identifi shigella sonnei shigella flexneri one shigella boydii one shigella dysenteria among salmonella isol identifi salmonella enteritidi salmonella typhimurium salmonella kentucki salmonella paratyphi b salmonella infanti salmonella cholerasui serovar salmonella agona salmonella dabou salmonella gallinarum salmonella hadar salmonella muenchen salmonella newport salmonella paratyphi c salmonella senftenberg respect esbl product determin shigella isol salmonella isol carbapenem resist ssenftenberg isol posit blaoxa resist gene detect studi meropenem mic valu isol detect gml gradient diffus test among isol one sboydii isol detect resist azithromycin mic valu gml isol posit exist mpha gene pcr disk diffus test azithromycin inhibit zone diamet mm test isol except azithromycin resist isol azithromycin mic determin g ml broth microdilut increas resist common use antibiot salmonella shigella speci emerg detect carbapenem resist salmonella isol studi indic spread carbapenem resist enterobacteral speci may caus global problem antimicrobi suscept test azithromycin salmonella shigella speci difficult establish due lack approv vitro breakpoint speci consequ data show azithromycin exhibit good altern therapeut choic treatment gastrointestin diseas caus salmonella shigella speci studi need provid appropri vitro breakpoint support clinic data | D017963;D012760 | T195;T007;T109 |
34,666,649 | phylotyp determin antimicrobi suscept cutibacterium acn isol patient acn vulgari cutibacterium acn former known propionibacterium acn oblig anaerob gram posit diphtheroid member normal skin microbiota frequent isol acn lesion also various infect opportunist pathogen within last decad distinct phylogroup cacn discov specif strain associ human diseas defin increas resist antimicrobi use treatment cacn infect report resist rate vari among isol differ geograph locat howev knowledg antimicrobi suscept pattern cacn limit turkey determin phylotyp cacn isol provid antimicrobi suscept data use understand pathogenesi diseas prevent develop resist appli ration effect empir treatment aim studi determin phylotyp antimicrobi suscept pattern cacn investig relationship among cacn phylotyp sever acn antimicrobi resist cacn isol cultiv acn lesion patient admit dermatolog outpati clinic univers hospit skin healthi control group six month period includ studi acn lesion face chestupp back given score accord global acn grade system gag describ sever acn sever grade mild score moder score sever score sever score isol identifi use matrix assist laser desorpt ionize time flight mass spectrometri maldi tof ms phylotyp analysi perform polymeras chain reaction pcr use specif primer minimum inhibitori concentr mic clindamycin erythromycin azithromycin tetracyclin doxycyclin determin agar dilut techniqu recommend clinic laboratori standard institut clsi anaerob bacteria major isol patient n control n patient control group phylotyp ia follow type ib type ii respect type iii cacn detect correl acn sever bacteri phylotyp resist rate clindamycin erythromycin azithromycin tetracyclin doxycyclin found acn patient group respect wherea control group incid resist antimicrobi respect signific differ antimicrobi resist patient control group except erythromycin p fisher exact well relationship found antimicrobi resist phylotyp group number isol resist two antimicrobi higher patient acn cacn isol high resist clindamycin erythromycin azithromycin type ia constitut major phylotyp signific relationship cacn phylotyp antimicrobi resist acn sever | D000152;D011425 | T007;T047 |
34,666,648 | relat uric acid level subclin hypothyroid diabet patient subclin hypothyroid sch frequent seen diabet patient elev level uric acid ua also report diabet patient studi assess relat sch ua level diabet patient aim evalu relat associ condit clinic laboratori paramet diabet patient | D003920;D007037 | T047 |
34,666,647 | right atrial thrombus patient rheumat heart diseas sever mitral regurgit rare associ right atrial thrombus rare phenomenon incid well defin usual occur presenc predispos factor like tricuspid stenosi follow central venous catheter isol right atrial thrombus without predispos factor occur rare | D008944;D008946;D012214;D013927;D014262 | T047;T046 |
34,666,646 | lobaplatin induc pyroptosi cervic cancer cell via caspas gsdme pathway increas evid show gsdme involv tumor chemotherapi lobaplatin import chemotherapi drug treatment cervic cancer howev exact mechan lobaplatin treatment cervic cancer remain unclear | D053148;D009944;D052899;D000069292;D002583 | T116;T191;T109;T043;T126 |
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