PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,665,536 | institut licens applic procedur medic care support covid pandem articl present analysi procedur medic care support implement case patient new coronavirus infect russia infecti diseas profil includ requir main licens requir analysi result public control complianc requir | D000086382;D058873 | T047;T067 |
34,665,535 | social demograph aspect vaccin popul russia context covid pandem pandem new corona virus infect covid popul immun develop condit achiev vaccin surviv diseas natur way recommend first mode achiev popul immun sinc immun respons vaccin similar one develop surviv natur infect minim risk health life articl present result sociolog survey organ purpos studi attitud russian vaccin covid infect result survey demonstr present respond readi vaccin ie respond posit correspond question follow main factor determin popul attitud vaccin identifi first statist signific correl vaccin readi educ level respond higher level educ like vaccin covid second general popul quit posit respons nation health care corona virus pandem howev percentag popul posit vaccin higher would possibl appli foreign made vaccin russia third still larg percentag popul believ vaccin medic pass long term clinic trial result health negat consequ fourth major respond experienc various manifest pandem either ill relat friend ill die almost somehow limit common mobilityth survey result establish statist signific differ distribut respons among male femal assum order develop posit attitud popul vaccin specif russian made vaccin extens inform campaign need implement also signific increas percentag vaccin popul achiev clear defin requir avail covid vaccin would adopt intern level actual key condit restor intern mobil remov restrict nation economi | D000086382 | T047;T067 |
34,665,534 | imag russian health care inform field second wave covid articl present result restudi russian health care inform field carri second wave covid mass media databas medialogia search engin yandex octob januari compar analysi result studi previous measur taken decemb may implement result studi portion panel studi russian health care system imag use hereinaft interest structur view adjust | D000086382 | T047;T067 |
34,665,533 | resourc support medic organ provid medic care twenti four hour hospit new corona virus infect covid articl consid basi applic modern inform analyt system sequenti stage analysi evalu indic resourc support medic organ technolog process medic care provis result studi permit discov particular pattern cours diseas differ gender age group term clinic manifest result instrument diagnost test depend result outcom treatment set qualiti resourc medic organ establish prognost indic function medic organ various altern patient flow organ associ hospit level | D000086382 | T047;T067 |
34,665,532 | covid catalyst develop telemedicin servic rural popul paper present review public concern issu develop telemedicin rural health care usa condit covid pandem expedi extens applic telemedicin technolog post covid period issu aspect prospect requir condit extens diffus telemedicin servic rural popul consid | D000086382;D017216 | T058;T047;T067 |
34,665,531 | intraocular pressur handgrip exercis effect postur hypercapnia young male part investig intraocular pressur iop potenti contribut factor spaceflight associ neuro ocular syndrom use head tilt hdt bed rest experiment model compar effect rest isometr exercis prone supin hdt posit iop observ seat posit | D015444;D018737;D007429;D016684;D016683 | T082;T056;T042;T061;T081;T040 |
34,665,529 | mix memori desir memori reactiv support delib decis make memori affect near everi aspect mental life allow us resolv uncertainti present construct plan futur recent renew interest role memori play adapt behavior led new theoret advanc empir observ review key find particular emphasi retriev mani kind memori affect delib action select result interpret sequenti infer framework reinstat memori serv sampl potenti action outcom result model suggest central role dynam memori reactiv determin influenc differ kind memori decis propos represent specif dynam implement bottom product expert rule integr multipl set action outcom predict weight base uncertainti close review relat find identifi area research articl categor psycholog reason decis make neurosci cognit neurosci comput | D003657;D008568 | T041 |
34,665,526 | calcium peroxid nanoparticl embed coat anti inflammatori tio nanotub bacteria elimin inflammatori environ amelior implant associ bacteri infect signific impair integr titanium soft tissu tradit antibacteri modif titanium implant abl elimin bacteria result pro inflammatori reaction usual ignor still pose potenti risk human bodi dual drug load system titanium develop via adhes catechol motif modifi methacryl gelatin hydrogel onto tio nanotub synthes cao nanoparticl nps embed hydrogel interleukin il load nanotub achiev antibacteri anti inflammatori properti dual drug load system elimin staphylococcus aureus aureus rapid attribut h releas cao nps potenti cytotox cao nps also remark reduc embed hydrogel import gradual releas il dual drug load system capabl modul pro inflammatori reaction induc phenotyp polar macrophag subcutan infect model aureus contamin effect resolv day result pro inflammatori reaction also inhibit day final damag tissu signific recov taken togeth dual drug load system exhibit great therapeut potenti effect kill pathogen inhibit result pro inflammatori reaction | D053758;D043942 | T073 |
34,665,525 | koolen de vri syndrom year old woman report oldest patient review adult phenotyp koolen de vri syndrom kdvs rare genet disord caus de novo microdelet chromosom region q encompass kansl de novo intragen pathogen variant kansl kdvs typic character intellectu disabl id variabl mild sever development psychomotor delay especi express languag develop friend disposit multipl system abnorm far individu affect kdvs diagnos infanc adolesc best knowledg includ adult report literatur present adult phenotyp year old italian woman affect kdvs caus q microdelet knowledg oldest affect individu report far collect clinic histori photograph well adult patient describ far compar propos cardin featur kdvs adulthood id rang mild sever usual moder friend behavior musculoskelet abnorm especi scoliosi facial dysmorph long face pronounc pear shape nose bulbous overhang nasal tip therefor suggest consid kdvs differenti diagnosi adult patient character featur | D008607 | T048 |
34,665,523 | identif chemic constitu vitro vivo er shen zhenwu decoct util ultra high perform liquid chromatographi quadrupol time flight mass spectrometri er shen zhenwu decoct prescript treat chronic heart failur heart kidney yang defici activ ingredi remain unclear difficult identifi paper aim appli rapid assay strategi ultra high perform liquid chromatographi quadrupol time flight mass spectrometri collect mass spectrometri data er shen zhenwu decoct decompos recip monarch minist assist compar retent time ms e fragment pattern compon vitro vivo identifi respect main ingredi includ saponin terpen alkaloid phenol acid tanshinon urea steroid aromat organ acid carbohydr forth monarch medicin minist medicin assist medicin comparison refer standard paeoniflorin rosmarin acid ginsenosid rg ginsenosid ginsenosid rb atractylenolid iii identifi vitro paeoniflorin ginsenosid rg ginsenosid ginsenosid rb identifi vivo studi chemic ingredi er shen zhenwu decoct analyz ultra high perform liquid chromatographi quadrupol time flight mass spectrometri technolog compound group decompos recip identifi substanc use refer er shen zhenwu decoct qualiti control potenti medicin substanc chronic heart failur heart kidney yang defici treatment | D008516 | T091;T060 |
34,665,521 | role collect duct princip cell nos sodium potassium homeostasi nitric oxid generat enzym synthas nos essenti sodium na homeostasi blood pressur control previous show collect duct princip cell nos critic inhibit epitheli sodium channel enac high na intak previous studi fresh isol cortic collect duct ccd demonstr exogen promot basolater potassium k conduct basolater channel presum k ir kcnj k ir kcnj therefor investig effect nos knockout k ir k ir channel activ inde cho cell overexpress nos k ir k ir inhibit signal decreas channel activ male litterm control princip cell nos knockout mice cdnosko day nacl diet hsd use detect chang basolater k conduct previous demonstr cdnosko mice high circul aldosteron despit high salt diet appropri suppress renin observ greater k ir cortic abund signific greater k ir k ir singl channel activ princip cell cdnosko mice moreov block aldosteron action vivo spironolacton treatment result lower k ir abund greater plasma k cdnosko mice compar control lower k content hsd prevent high aldosteron greater plasma na cdnosko mice normal k ir abund conclud chronic hsd lack nos lead increas plasma k enhanc circul aldosteron activ enac k ir k ir channel thus princip cell nos requir regul na k kidney | D006706 | T038 |
34,665,518 | role ventilatori support long term outcom critic infect covid prospect cohort studi full rang long term health consequ intens care unit icu survivor covid unclear studi aim investig role ventilatori support long term pulmonari impair critic ill patient identifi risk factor prolong radiolog recoveri | D000086382 | T047;T067 |
34,665,517 | social adjust survivor acut lymphoblast leukemia without cranial radiat therapi evalu group differ social adjust survivor pediatr acut lymphoblast leukemia compar survivor sibl control identifi diseas relat predictor social adjust survivor explor whether execut function explain differ social adjust across group diseas relat predictor | D016371;D054198;D012917 | T191;T061;T054 |
34,665,516 | biotransform ginsenosid rb rb rb rc human intestin bacteria effect intestin flora ginsenosid includ rb rb rb rc belong protopanaxadiol type saponin panax ginseng c mey content high p ginseng could inhibit oxid stress enhanc immun lower blood sugar resist tumor cell facilit physiolog activ studi aim explor interact ginsenosid rb rb rb rc intestin flora healthi peopl also sought analys biotransform product pathway ginsenosid vitro human intestin bacteria effect divers human intestin flora human intestin bacteria incub ginsenosid rb rb rb rc c anaerob condit sampl taken differ timepoint transform product identifi rapid high resolut liquid chromatographi quadrupol time flight mass spectrometri h transform transform product ginsenosid rb rb rb rc ginsenosid compound k transform rate rrna sequenc technolog appli bioinformat analysi faecal sampl incub h relat blank control relat abund firmicut proteobacteria signific increas phylum level moreov relat abund bacteroidet signific decreas ginsenosid rb rb rb rc genus level relat abund escherichia signific increas wherea dorea prevotella megasphaera signific decreas group result show rb rb rb rc could improv structur divers human intestin flora balanc metabol process | D000069196 | T007;T001 |
34,665,514 | polyacetylen glycosid isol biolog activ synthesi polyacetylen glycosid pag constitut relat small class secondari metabolit character presenc sugar unit anomer connect polyacetylen compound found fungi seawe often plant pag exhibit wide rang biolog pharmacolog activ result literatur compound grown exponenti recent year | D006027;D053279 | T121;T109 |
34,665,512 | success periop manag use prothrombin complex concentr patient sever congenit protein c defici periop manag sever congenit protein c defici remain unestablish defici often treat anticoagul warfarin although anticoagul need periop discontinu method manag patient adopt method administ prothrombin complex concentr pcc includ intermitt administr inact protein c ppsb ht examin outcom periop manag approach sever congenit protein c defici three patient underw periop manag six time monitor activ level protein c factor ix forth patient could periop manag pcc treatment | D020151 | T047 |
34,665,509 | renal nurs experi patient sever mental health condit receiv acut haemodialysi qualit studi patient receiv acut haemodialysi treatment live sever mental ill may display behaviour perceiv challeng stress renal nurs manag acut haemodialysi unit renal nurs histor train technic aspect acut haemodialysi provid level psycholog support patient howev train manag patient sever mental ill | D001523;D009726 | T097;T048 |
34,665,508 | pattern vertebr cardiac progenitor field retino acid signal influenc retino acid ra signal vertebr develop well studi histori cumul understand ra signal conserv requir earli develop restrict cardiac progenitor within anterior later plate mesoderm vertebr embryo moreov genet pharmacolog manipul ra signal vertebr model shown proper heart develop achiev deploy posit negat feedback mechan maintain appropri ra level brief review present chronolog overview key work led current model critic role earli ra signal limit generat cardiac progenitor within vertebr embryo furthermor integr previous work mice recent find use zebrafish togeth show ra signal remark conserv influenc later differenti progenitor popul arteri venous pole discuss recogn signific conserv ra signal differenti progenitor popul offer new perspect may impact futur work dedic examin vertebr heart develop | D015398 | T043;T044 |
34,665,507 | increas post digest solubl curcumin success strategi improv oral bioavail random cross trial healthi adult vitro bioaccess experi differ mechanist approach improv low oral bioavail curcumin develop yet direct compar human | D003474 | T130;T121;T109 |
34,665,504 | dapson hidraden suppurativa case seri patient hidraden suppurativa hs chronic inflammatori diseas challeng treatment current guidelin reserv dapson third line agent patient mild moder hs knowledg four small case seri report object studi assess effect safeti dapson clinic practic retrospect observ singl center studi hs patient underw treatment dapson may june perform hidraden suppurativa clinic respons hiscr scale use evalu respons treatment fifti six patient includ men median age year mild moder diseas belong lc follicular phenotyp patient refractori first line treatment dapson prescrib dose mgday patient achiev hiscr week treatment serious advers reaction detect median durat treatment month multivari analysi associ found presenc fistul tract risk non respons drug four dapson respond oral retinoid ad achiev sustain respons limit includ retrospect non control natur studi conclus dapson effect well toler option long term hs treatment seri main chosen patient lc phenotyp would interest studi combin retinoid manag option | D017497 | T047 |
34,665,491 | physiolog lead placement electroanatom map case seri bundl pace hbp left bundl branch area pace lbbap emerg attract altern tradit biventricular pace achiev cardiac resynchron therapi earli report result inconsist particular amongst patient initi placement tradit approach unsuccess complex anatomi congenit abnorm report describ use three dimension electroanatom map eam five select case | D002036;D058406 | T023;T061 |
34,665,489 | preval risk factor repair mechan differ form sinus membran perfor later window sinus lift procedur retrospect cohort studi evalu preval affect risk factor effort repair mechan differ form sinus membran perfor smp sinus floor elev sfe use later window techniqu lwt | D059546 | T061 |
34,665,488 | linc promot hepatocellular carcinoma develop target mir poxsr axi hepatocellular carcinoma hcc one common cancer worldwid recent studi demonstr lncrnas play import role tumorigenesi linc confirm involv prolifer migrat differ cancer although function linc hcc still unknown | D006528;D008113;D035683 | T191;T114;T123 |
34,665,487 | spatiotempor imag analysi mous human liver bud morphogenesi process liver organogenesi serv paradigm organ format howev remain lack understand regard earli mous human liver bud morphogenesi earli liver volumetr growth elucid dynam chang liver volum critic understand organ develop implement toxicolog studi model hpsc deriv liver organoid growth new visual analysi experiment techniqu desper need | D038081;D039904 | T025;T038 |
34,665,485 | robot arm assist bicompartment knee arthroplasti durabl result year follow purpos studi investig mid term clinic function outcom robot arm assist bicompartment knee arthroplasti bika | D019645;D007720;D020370;D065287 | T047;T074;T061 |
34,665,484 | exploit structur metamorphosi polym wrap micron size spheric object grow interest develop method wrap nano micron size biolog object within film may offer protect enhanc stabil improv perform describ success wrap lectin decor microspher serv appeal model micron size object within cross link polym film approach util polym chain abl undergo structur metamorphosi intramolecular cross link intermolecular cross link process trigger polym concentr upon particl surfac experi demonstr complementari molecular recognit dynam coval natur crosslink requir success wrap occur work signific suggest nano micron size biolog object virus like particl bacteria mammalian cell may benefit addit environment protect stabil emerg applic may also wrap approach | D011108 | T104;T122 |
34,665,481 | engin extracellular vesicl enrich palmitoyl ace covid therapi angiotensin convert enzym ace key receptor present cell surfac direct interact viral spike protein sever acut respiratori syndrom coronavirus sar cov propos inhibit interact promis treat covid presenc ace extracellular vesicl ev report ev ace level determin protein palmitoyl cys cys residu ace palmitoyl zinc finger dhhc type palmitoyltransferas zdhhc de palmitoyl acyl protein thioesteras lypla critic membran target ace ev secret import fuse palmitoyl depend plasma membran pm target sequenc ace ev enrich ace surfac refer pm ace ev engin shown pm ace ev bind sar cov rbd high affin block interact cell surfac ace vitro pm ace ev show neutral potenc pseudotyp authent sar cov human ace hace transgen mice effici block viral load authent sar cov thus protect host sar cov induc lung inflamm studi provid effici engin protocol construct promis novel biomateri applic prophylact therapeut treatment covid | D000086382;D000067128 | T026;T047;T067 |
34,665,479 | valid point care tear film osmomet diagnosi dri eye determin repeat tearlab pen osmomet vivo accuraci vitro | D015352;D019095 | T058;T047;T184 |
34,665,478 | outcom mitral repair degen versus ischem mitral regurgit use singl complet ring durabl surgic repair degen versus ischem mitral regurgit mr thought mark differ therefor examin late outcom durabl mitral repair larg cohort patient receiv singl annuloplasti devic | D058386;D008944 | T047;T061 |
34,665,477 | percutan cannul cardiopulmonari bypass robot mitral valv surgeri zero groin complic robot valv surgeri util femor vessel set cardiopulmonari bypass cpb translat groin wound lower extrem vascular complic less invas techniqu total percutan bypass use vascular closur devic vcds concern lower limb ischemia arteri stenosi sinc april adopt standard use total percutan cpb robot mitral case report institut result techniqu | D006348;D065287 | T061 |
34,665,476 | machin learn new frontier mitral valv surgic strategi one surgic option avail ischem mitral regurgit mr mitral valv repair limit recurr regurgit experienc signific percentag patient negat impact patient outcom effort model identifi predictor recurr mr reli complic echocardiograph clinic measur subject routin collect | D006348;D008944 | T047;T061 |
34,665,475 | toward postbiot era microbiom scienc opportun advanc immunotherapi hepatocellular carcinoma microbiom revolution field cancer immunolog checkpoint therapeut gastrointestin malign combat hepatocellular carcinoma hcc immun checkpoint blockad icb uniqu challeng due part chronic complic aris local system metabol dysfunct gut microbi metabolit modul key immunolog process influenc liver cancer suscept resist icb review discuss recent progress link microbiota function hcc tumor immun highlight therapeut potenti | D006528;D007167;D008113 | T191;T061 |
34,665,474 | slow gait speed associ wors postop outcom cardiac surgeri systemat review meta analysi frailti associ poorer outcom cardiac surgeri heterogen frailti assess tool make difficult ascertain true impact cardiac surgeri slow gait speed simpl valid reliabl marker frailti perform systemat review meta analysi examin effect slow gait speed postop cardiac surgic patient | D006348;D000073496 | T033;T046;T184;T061 |
34,665,473 | preemptiv transjugular intrahepat portosystem shunt improv surviv acut varic bleed systemat review meta analysi trial sequenti analysi random trial preemptiv transjugular intrahepat portosystem shunt p tipss acut varic bleed avb advoc howev compar current standard care surviv benefit p tipss question perform systemat review meta analysi trial sequenti analysi random control trial rcts assess surviv benefit p tipss patient cirrhosi avb | D004932;D006471;D008103;D019168 | T046;T047;T061;T020 |
34,665,472 | effect selenium free parenter nutrit serum selenium neonat infant maintain long term parenter nutrit risk selenium defici increas infant receiv long term parenter nutrit pn studi analyz selenium defici neonat infant requir long term pn evalu effect intraven iv selenium provis | D012643 | T121;T196;T123 |
34,665,471 | evalu energi intak compar indirect calorimetri requir critic ill patient acut brain injuri nutrit support critic ill patient acut brain injuri vital import known hypermetabol aim describ energi protein intak within first h broad neurocrit care popul compar energi intak indirect calorimetri ic rest energi expenditur ree target | D001930;D000083242 | T047;T037 |
34,665,470 | enhanc elimin betamethason dichorion twin pregnanc studi evalu betamethason pharmacokinet twin pregnanc accord chorion studi aim describ compar betamethason pharmacokinet paramet singleton dichorion dc monochorion twin pregnanc third trimest pregnanc | D001623;D059285 | T033;T121;T109;T125 |
34,665,469 | long chain acyl coa synthetas activ fatti acid lipid synthesi remodel energi product chlamydomona long chain acyl coa synthetas lacss play mani role mammal yeast plant knowledg function microalga remain fragment via genet biochem physiolog analys unravel function role lacss model microalga chlamydomona reinhardtii vitro assay purifi recombin protein reveal crlac crlac crlac exhibit bona fide lac activ toward broad rang free fatti acid chlamydomona mutant compromis crlac crlac crlac show obvious phenotyp lipid content growth nitrogen n replet condit n depriv crlac crlac suppress result c less oil yet higher amount chloroplast lipid contrast crlac suppress impair oil remobil cell growth sever n recoveri support role fatti acid oxid provid energi carbon sourc regrowth transcriptom analysi suggest observ lipid phenotyp like due transcript reprogram rather shift metabol adjust taken togeth studi provid solid experiment evid essenti role three chlamydomona lac enzym lipid synthesi remodel catabol highlight import lipid homeostasi cell growth nutrient fluctuat | D002696;D016825 | T204;T002 |
34,665,468 | efficaci water soap water skin decontamin chemic warfar agent simul use vitro human model systemat review water water soap wide recommend prefer solut dermal decontamin howev limit efficaci data exist summar experiment studi evalu vitro efficaci water soap water decontamin chemic warfar agent cwa simul human skin model embas covid medlin pubm web scienc googl scholar search articl use water soap water decontamin method remov cwacwa simul vitro human skin model data extract complet seven studi yield seven contamin water decontamin led partial decontamin skin sampl n soap water decontamin led partial decontamin skin sampl n four studi found decontamin either paradox enhanc absorpt contamin penetr rate known wash effect despit recommend water water soap decontamin found yield partial decontamin cwa simul human vitro studi thus effect decontamin agent need studi demonstr increas faster penetr chemic follow decontamin could prove dead agent vx although find requir vivo valid heterogen experiment setup limit interstudi comparison remain unclear water water soap ideal decontamin requir studi pend manuscript summar vivo human anim efficaci data intern harmon efficaci protocol enabl effici public health decis evid base public health decis | D002619 | T131 |
34,665,467 | comparison risk score system heparin induc thrombocytopenia cardiac surgeri patient sever risk score tool develop exclud heparin induc thrombocytopenia hit patient thrombocytopenia score reproduc compar cardiac surgeri popul object studi valid compar modifi mt lillo le louet lll score hit screen cardiac surgeri popul | D006348;D006493;D013921 | T047;T121;T109;T123;T061 |
34,665,466 | impact rainfal distribut method streamflow throughout multipl elev rocki mountain use apex model price river watersh utah hydrolog mountain watersh western unit state signific influenc snow year round wide known topographi affect precipit howev knowledg watersh rainfal design method affect streamflow well understood high relief area object studi assess predict capabl agricultur policyenvironment extend apex model simul streamflow snowmelt domin watersh high spatial rainfal variabl alloc weather station sub basin base convent thiessen polygon method cm rainfal elev base input use areal averag paramet elev regress independ slope model prism rainfal design b improv snowmelt process price river watersh utah updat apex model snowmelt paramet signific improv spring flood simul robust method snowmelt season streamflow simul compar cm prism rainfal design adapt apex model simul snow domin complex terrain provid crucial water quantiti qualiti predict reliabl environment watersh manag assess | D004784;D045483 | T070;T057 |
34,665,465 | calmodulin like protein cml interact camta wrki regul almt depend al resist arabidopsi thaliana aluminum activ malat transport almt mediat malat exud root critic aluminium al resist arabidopsi upstream molecular signal regul yet well understood role calmodulin like cml al inhibit root growth downstream molecular regul almt medita al resist investig cml confer al resist demonstr increas root growth inhibit cml loss function mutant al stress occur main regul almt mediat malat exud root mutat overexpress cml lead elev reduc al accumul cell wall root respect al stress induc transcript protein abund cml root tip especi transit zone cml interact calmodulin bind transcript activ camta promot transcript activ regul almt express result enhanc malat exud root less root growth inhibit al stress cml camta interact wrki suppress transcript repress almt wrki studi provid novel insight understand upstream molecular signal almt depdend al resist | D017360;D029681;D027361 | T116;T002;T123 |
34,665,464 | impact upper later cartilag releas patient perceiv nasal appear obstruct although upper later cartilag common releas dorsum septum spreader graft placement septorhinoplasti srp focus maintain integr connect middl vault avoid releas upper later cartilag certain patient group may repres earli step paradigm shift aim assess satisfact nasal appear correct nasal obstruct patient underw srp spreader graft placement without upper later cartilag releas compar tradit upper later cartilag releas cohort | D015508;D012225 | T033;T047;T061 |
34,665,463 | demograph risk factor malnutrit patient cleft lip palat patient cleft lip andor palat clp increas risk malnutrit acut chronic malnutrit associ elev risk postsurg wound complic ad morbid cost patient famili studi associ demograph factor includ insur type race median neighborhood incom mni malnutrit patient clp | D002971;D002972;D044342 | T047;T019 |
34,665,459 | inconsist annual compens floral herbivori iterocarp thistl plant experienc steep reproduct loss herbivor favor strategi promot toler resist herbivori howev degre strategi succeed improv plant fit natur condit need evalu especi iterocarp speci test whether reproduct effort iterocarp cirsium undulatum spreng wavyleaf thistl provid within season toler floral herbivori respons apic damag | D031180;D060434 | T040;T008;T002 |
34,665,457 | kidney injuri molecul urinari gamma glutamyl transferas biomark acut kidney injuri cat evalu concentr kidney injuri molecul activ urinari gamma glutamyl transferas cat urethr obstruct healthi cat | D058186;D002371;D014524 | T047;T037 |
34,665,455 | prepar vitro character gelatin methacryl corneal tissu engin corneal diseas second cataract consid lead caus blind world high morbid construct corneal substitut vitro tissu engin technolog achiev corneal regener becom research hotspot recent year conduct depth research biocompat physicochem mechan properti rat bone marrow mesenchym stem cell rbm mscs seed gelatin methacryl gelma bioengin cornea | D005780;D023822 | T116;T121;T061 |
34,665,454 | current modal fractur heal enhanc previous fractur treat bone reduct immobil increas patient need earli return normal function develop surgic techniqu materi acceler howev delay union non union fractur site sometim inhibit immedi return normal life enhanc fractur heal divers materi method develop review current modal fractur heal enhanc aim provid comprehens knowledg regard fractur heal research health practition | D017102;D050723 | T042;T037 |
34,665,453 | effect metformin myoinositol metabol outcom women polycyst ovari syndrom role bodi mass adiponectin random control trial compar effect insulin sensit metformin met myo inositol mi adiponectin level metabol characterist women polycyst ovari syndrom pcos respect bodi mass index bmi | D009765;D011085 | T047 |
34,665,451 | path toward progress critic review advanc scienc femal male athlet triad relat energi defici sport energi status play key role health athlet exercis individu energi deficiencylow energi avail ea refer state insuffici energi intak andor excess exercis energi expenditur result compensatori metabol adapt conserv fuel affect numer physiolog system women men femal athlet triad male athlet triad relat energi defici sport red model conceptu effect energi defici athlet model strength limit instanc femal athlet triad model depict relationship low ea reproduct bone health underpin decad experiment evid may perceiv limit scope recent red model propos wider rang potenti health effect low ea though mani model compon requir robust scientif justif critic review summar current evid regard effect energi defici athlet health address qualiti under scienc strength limit model highlight area futur research need advanc field health well athlet exercis individu overarch prioriti conclud specif step help focus futur research femal male athlet triad red encourag research clinician practition collabor support common goal promot highest qualiti scienc evid base medicin pursuit advanc athlet health well perform | D053716;D000080822 | T048;T047 |
34,665,450 | ishii test screen sarcopenia perform communiti dwell older adult sarcopenia associ increas likelihood major advers health outcom therefor screen earli time identif sarcopenia essenti ewgsop european work group sarcopenia older peopl suggest ishii screen test formal case find aim defin diagnost valu ishii screen test estim probabl sarcopenia use equat deriv score base three variabl age grip strength calf circumfer turkish older adult | D055948 | T047 |
34,665,449 | util instagram psychiatri resid program virtual recruit world mani psychiatri resid program use instagram provid inform program studi assess content engag psychiatri resid program instagram account | D007396;D011570;D061108 | T097;T065;T170;T091 |
34,665,447 | analysi risk factor treatment outcom patient present neglect congenit spinal deform neurolog deficit congenit spinal deform csd uncommon usual present earli childhood rare patient report present neglect csd associ myelopathi current studi report largest seri patient neglect csd major neuro deficit discuss long term outcom | D007738;D012600 | T190;T047 |
34,665,445 | secukinumab review moder sever pediatr plaqu psoriasi subcutan secukinumab cosentyx recombin fulli human immunoglobulin ig g monoclon antibodi target interleukin il proinflammatori cytokin involv pathogenesi psoriasi secukinumab approv eu usa treatment moder sever plaqu psoriasi pediatr patient age year pivot phase iii trial pediatr patient age year low mg high mg dose secukinumab signific better placebo numer better etanercept week term proport patient achiev improv baselin psoriasi area sever index signific better placebo etanercept term proport patient achiev investig global assess score clinic efficaci secukinumab observ first week treatment maintain longer term treatment secukinumab improv health relat qualiti life general well toler conclus secukinumab repres valuabl new addit limit treatment option avail children adolesc moder sever plaqu psoriasi | D011565;D011788 | T047;T078 |
34,665,444 | clinic outcom patient femoropoplit arteri diseas endovascular therapi focus drug coat balloon relat distal embol detect laser doppler flowmetri sever trial shown paclitaxel drug coat balloon dcbs signific reduc restenosi rate howev report shown distal embol occur dcbs studi analyz clinic outcom patient dcb induc distal embol studi aim investig clinic outcom dcb induc distal embol patient femoropoplit arteri diseas februari april consecut patient n present de novo femoropoplit arteri diseas underw endovascular therapi use dcb retrospect review singl center studi patient divid two group base whether distal embol detect use laser doppler flowmetri del group non del group baselin characterist year clinic outcom compar group del found limb del group n non del group n knee arteri runoff p poplit lesion p ambul difficulti p previous histori coronari arteri diseas p identifi predict factor del procedur factor refer vessel diamet lesion length total drug amount predict del overal target lesion restenosi tlr rate n tlr rate signific differ del non del group vs p sever calcif signific factor tlr vs p among patient femoropoplit diseas differ year clinic outcom patient underw del | D000800;D002317;D004617;D058729 | T047;T121;T046;T061;T033 |
34,665,442 | roux en happen fix roux en gastric bypass surgeri improp techniqu caus complic roux en caus inadvert anastomosi biliopancreat limb gastric pouch creat form bypass present intraop imag mistaken roux en techniqu caus anatomi success reconstruct | D015390;D010535;D009767 | T047;T060;T061 |
34,665,441 | evalu intens telephon nutrit lifestyl counsel enhanc outcom bariatr surgeri determin impact intens periop nutrit lifestyl support protocol long term outcom bariatr surgeri | D050110;D015390;D009767 | T047;T061 |
34,665,439 | epidemiolog molecular mechan clinic trial updat research associ red meat consumpt colorect cancer colorect cancer second common caus cancer death world aim review provid updat recent epidemiolog studi molecular mechan involv ongo clinic trial investig relationship red meat consumpt colorect cancer | D015179;D008461;D000069466 | T191;T168 |
34,665,437 | qualiti indic excel requir multidisciplinari lung cancer tumor board spanish lung cancer group multidisciplinari care need decid best therapeut approach provid optim care patient lung cancer lc multidisciplinari team mdts optim strategi manag patient lc associ better outcom increas qualiti life surviv spanish lung cancer group promot review current situat exist nation lc mdts also offer set excel requir qualiti indic achiev best care patient lc time suffici resourc leadership administr institut support record activ key factor success lc mdts set excel requir term staff resourc organ lc mdt propos last list qualiti indic agre achiev measur perform current lc mdts | D010348;D019984 | T058;T080;T081 |
34,665,436 | identifi women increas risk breast cancer implement risk reduc strategi supplement imag breast cancer bc second common cancer women affect women unit state lifetim howev women higher lifetim risk bc genet lifestyl factor mammograph breast densiti reproduct hormon factor bc risk variabl screen prevent strategi individu consid patient specif risk factor thus health care profession need abl assess risk profil identifi high risk women individu screen prevent strategi share decis make process articl review risk factor bc risk assess model identifi high risk patient prevent medic lifestyl modif may decreas risk also discuss benefit limit various supplement screen method | D018570 | T058;T080;T062 |
34,665,435 | trend adjuv therapi breast conserv surgeri ductal carcinoma situ breast retrospect cohort studi use nation breast cancer registri japan radiotherapi rt endocrin therapi et standard treatment option breast conserv surgeri bcs ductal carcinoma situ dcis investig nation pattern adjuv therapi use bcs dcis japan | D015412 | T061 |
34,665,433 | function properti prick pear cactus fruit peel undergo supplement irrig fruit storag condit prick pear cactus fruit peel seen organ wast studi explor effect supplement irrig fruit growth roja lisa opuntia ficus indica prick pear cactus antioxid hypoglycem hypolipidem properti peel extract fruit collect harvest storag condit treatment non irrig supplement irrig storag condit cold room temperatur fresh harvest fruit fruit qualiti evalu peel treatment combin pool concentr phenol compound inhibit vitro digest enzym antioxid capac vivo hypoglycem control mgdl versus fruit peel extract mgdl min hypolipidem control mgdl versus fruit peel extract mgdl min properti determin therefor fruit peel could potenti har human health benefit instead treat organ wast | D029747 | T002 |
34,665,432 | bioinformat predict analysi microrna target biomark prostat cancer preliminari studi prostat cancer pca second common form cancer men around world due heterogen present rang aggress lethal diseas indol diseas need identifi core biomark import earli detect progress allow precis method treatment manag pca obtain metastat prostat cancer associ microrna array profil gse dataset geo databas microrna target predict done use databas targetscanhuman mirdb diana microt six target gene foxc cdkna birc ctnnd elk lrp found common among three differ databas differenti express target gene perform via gent databas gpl platform hg ua result indic gene downregul gene ontolog go use perform enrich analysi go enrich analysi indic downregul gene enrich cellular respons gamma radiat regul transcript respons drug well protein bind receptor signal protein activ studi suggest cdkna foxc birc might core gene prostat cancer play import role diagnosi develop progress | D035683;D011471 | T191;T114;T123 |
34,665,430 | use new criteria improv differenti hcc non hcc malign clinic practic discuss ceus li rad use contrast enhanc ultrasound ceus evalu diagnost perform liver imag report data system li rad version explor potenti way improv efficaci | D003287 | T130 |
34,665,427 | risk factor associ diseas specif mortal papillari thyroid cancer patient distant metastas papillari thyroid carcinoma ptc among curabl cancer type even though uncommon patient present distant metastat diseas diagnosi follow long term surviv howev continu controversi regard clinicopatholog featur associ mortal patient paper evalu factor relat poor diseas specif surviv dss patient metastat ptc | D007457;D013964 | T131;T191;T196 |
34,665,425 | neighborhood context nativ advantag preterm birth among black women california usa non hispan black women remain increas risk advers birth outcom yet black immigr women lower risk us born counterpart studi examin whether neighborhood context contribut nativ advantag preterm birth ptb week among black women california sampl live singleton birth non hispan us born n african born n caribbean born n black women drawn california birth record geocod urban census tract use american communiti survey data measur tract level black immigr densiti black racial concentr neighborhood depriv index risk ratio rr confid interv ci estim use log binomi regress assess whether neighborhood context partial explain nativ differ ptb risk compar us born black women african born black women lower ptb risk rr ci differ ptb risk us caribbean born women reach statist signific rr ci nativ advantag ptb risk robust neighborhood social condit matern factor african born women rr ci studi one consid area level explan nativ advantag among black immigr make signific contribut show neighborhood context explain nativ advantag ptb among black women california could due mani factor examin futur research | D054242;D047928 | T046;T098 |
34,665,424 | earli experi crotalida immun f ab antivenom treat arizona rattlesnak envenom crotalida immun f ab fabav becam avail usa treatment rattlesnak envenom clinic trial compar fabav crotalida immun polyval fab fabav fabav associ less late hemotox purpos studi describ outcom follow use fabav patient rattlesnak envenom arizona | D003435;D012909 | T116;T109;T123;T131;T037 |
34,665,422 | systemat review iron base nanoparticl mediat clean textil dye challeng prospect scale technolog project increas global textil industri usd billion indic simultan increas water pollut due textil dye rich volumin effluent highlight requir sourc clean review analyz coloss amount literatur lab scale nanoremedi technolog involv iron base nanoparticl mechanist aspect howev mani studi place regard execut sever bottleneck scale technolog review attempt identifi limit scale focus step nanoremedi synthesi iron base nanoparticl applic promin appear low econom viabil physico chemic synthesi nanoparticl lack appropri toxic studi iron base nanoparticl dearth studi field applic recommend studi made lab scale also field sampl prefer util microbi product base green synthes iron base nanoparticl conduct toxic studi besid immobil nanoparticl renew materi great enhanc sustain econom valu process furthermor sinc chemic composit dye rich effluent vari among industri effluent specif optim process paramet kinet thereof also major prerequisit scale valu review lie fact bring first time comprehens critic systemat various aspect need attent order scale effect nanoremedi process | D053758;D014874 | T131;T073 |
34,665,421 | behavior mercuri releas iron ore temperatur program heat treatment air behavior hg releas iron ore temperatur program heat treatment tpht air studi primarili use onlin monitor method hg releas behavior tpht depend signific type ore process involv evolv form hg hg remain thermal stabl c furthermor tpht experi model hg compound suggest presenc sever type hg form hgcl hg cl hgs hgo hgso associ miner hg consid iron ore find studi provid insight design effici method remov hg iron ore gaseous hg | D008628;D017669 | T131;T196;T197 |
34,665,420 | analysi effect coronavirus covid pandem movement control order mcos solid wast generat peninsular malaysia studi intend deal environment consequ covid pandem malaysia provid summari effect covid municip solid wast msw analysi data domest wast collect collect solid wast manag public clean corpor swcorp januari decemb evalu relat chang msw percentag via wast weigh method data consist cumul tonnag msw everi local author peninsular malaysia classifi accord mco phase mco mco condit mco cmco recoveri mco rmco phase result indic enforc earli mco show posit effect decreas volum msw decreas note across local author account peninsular malaysia howev amount msw began increas mco reach condit recoveri stage conclud implement mco various incarn shown us lifestyl harm impact environ pandem still spread limit still place malaysia local govern wast manag compani quick alter wast manag system procedur current circumst allow us rethink social econom structur improv environment social inclus | D000086382;D012037;D018505 | T047;T057;T068;T067 |
34,665,419 | impact govern environment pollut countri middl east sub saharan africa evid panel quantil regress causal govern one basic determin pollut level properti right effect judici system etc accept bad govern ineffici regulatori structur govern bureaucraci weak law enforc etc support environment pollut context countri middl east sub saharan africa studi impact govern environment pollut period panel quantil granger causal method countri select consid two differ measur epi index govern index accord epi countri low score term environment qualiti govern index bad govern score studi panel quantil regress model use control variabl includ model prevent omit variabl bias result analysi determin effect govern carbon emiss posit well effect independ variabl co emiss heterogen across quantiti panel quantil regress reveal evid relat among environment pollut two paramet govern fdi financi develop human develop index trade open use explanatori variabl determin govern greatest posit effect co emiss hand use tradit granger causal dumitrescu hurlin causal method found evid causal among govern environment pollut context two paramet govern accord determin evid unidirect causal relat polit govern environment pollut besid econom govern environment pollut determin evid unidirect causal fdi explanatori variabl environment pollut | D002245;D057217 | T081;T197;T123 |
34,665,418 | time seri analysi short term effect particul matter pollut circulatori system diseas mortal risk lishui district china epidemiolog evid shown signific associ short term exposur air pollut mortal risk circulatori system diseas csd howev inform insight signific magnitud relationship process govern intervent abat air pollut still lack particular burgeon chines citi studi conduct time seri studi lishui district nanj examin effect ambient particul matter pm eg pm pm daili death count csd includ cardiovascular diseas cvd cerebrovascular diseas cevd arteriosclerot heart diseas ashd mortal januari decemb result reveal gm increas pm pm concentr lag day associ increas confid interv csd mortal cvd mortal cevd mortal ashd mortal respect cumul risk correspond increas daili mortal chang pm concentr lag day signific associ csd cvd cevd ashd respect exposur respons curv approxim nonlinear entir exposur rang pm concentr also analyz effect modif season warm cold age group year year year sex male femal although statist signific stratifi analysi show greater vulner pm exposur cold season popul year age femal group | D000393;D000397;D002318;D002319 | T022;T047;T131;T080;T069 |
34,665,417 | spatial spillov threshold effect green financ environment qualiti evid china green financ prioriti allevi environment degrad pressur base panel data provinc china studi util spatial durbin model sdm threshold model examin effect green financ environment qualiti empir result follow green financ environment qualiti signific posit spatial autocorrel develop green financ china still lower level rang high high low low domin spatial cluster type green financ signific posit effect local environment qualiti negat effect neighbor research period howev spatial spillov effect green financ heterogen three subsampl doubl threshold effect green financ environment qualiti effect decreas promot green financ empir insight provid spatial refer policymak formul strategi target coordin integr region develop | D057217 | T081 |
34,665,416 | explor potenti role rho gtpase nicotin depend induc withdraw syndrom mice rhoa gene show import genotyp associ nicotin depend smoke initi current studi aim investig effect rho gtpase inhibitor ml progress nicotin depend mice model precipit nicotin withdraw syndrom mecamylamineth experiment procedur involv administr mgkg nicotin dissolv normal salin subcutan sc four time day consecut day last singl dose morn th day ml dissolv dimethyl sulfoxid dmso administ daili nicotin correct treatment dose mgkg p inject mgkg mecamylamin intraperiton ip given hour later last nicotin dose day precipit withdraw nicotin withdraw sever assess measur hyperalgesia piloerect jump frequenc tremor withdraw sever score wss various behaviour chang hyperalgesia piloerect jump frequenc tremor monitor wss calcul ml select rho gtpase inhibitor found show dose depend effect paramet inhibit rho gtpase found reduc sever withdraw syndrom therefor conclud rho gtpase would serv suitabl biolog target regul reward system brain could use new target drug discoveri | D013375;D014029 | T048;T184 |
34,665,415 | pani fe zno nanocomposit magnet recover organometal nanocatalyst promot synthesi new azo chromen dye evalu antioxid antimicrobi activ new seri azo chromen dye synthes via facil cyclocondens reaction e diphenyl diazen aminocoumarin molar ratio catalyz polyanilin fe zno nanocomposit pani fe zno salient featur protocol lie simpl experiment procedur moder reaction condit use pani fe zno nanocomposit magnet separ heterogen catalyst two well known method employ assess antioxid abil target compound includ free radic trap diphenyl picrylhydrazyl dpph well ferric reduc antioxid power assay also sever synthes compound screen vitro antimicrobi activ employ disk diffus test gram negat well gram posit bacteria | D000890;D015034 | T121;T197 |
34,665,414 | unplan vs plan periton dialysi initi therapi dialysi patient chronic kidney replac therapi compar infecti mechan complic techniqu failur mortal plan pd vs unplan pd program | D007676;D010530;D010538 | T047;T061;T046 |
34,665,413 | prolong qtc interv begin dialysi associ hypervolemia calcium magnesium chang first h high rate sudden cardiac death most attribut ventricular arrhythmia includ qtc prolong hemodialysi patient aim investig correl electrolyt volum chang qtc interv prolong hemodialysi patient | D008133;D014570;D014883 | T033;T047;T046 |
34,665,412 | effect blood volum chang relat intens intradialyt aerob exercis hemodialysi adequaci pilot studi intradialyt exercis may improv dialysi effici howev associ chang blood volum bv relat exercis intens solut remov kinet remain unknown herein investig relationship chang bv exercis remov solut molecul hemodialysi | D007676 | T047 |
34,665,411 | ventral prosthesi rectopexi obstruct defaec syndrom systemat review meta analysi obstruct defec syndrom od rather complex entiti concern main femal caus primarili constip surgic treatment form ventral prosthesi rectopexi vpr propos seem best outcom howev select criteria patient undergo kind oper clear report outcom main short term data long term outcom scarc studi assess new evid efficaci vpr treatment od specif focus inclus criteria surgeri long term outcom search perform medlin embas ovid cochran databas studi report vpr od march languag restrict made studi vpr review systemat main outcom intra oper complic convers procedur durat short term mortal morbid length stay faecal incontin constip qualiti life qol score patient satisfact qualiti assess data extract perform independ three observ fourteen studi includ patient elig analysi immedi postop morbid rate signific improv constip symptom observ month postop period od p current evid show vpr offer symptomat relief major patient od improv constip like symptom faecal incontin least year postop studi report function result longer follow show sustain improv although lesser extent | D003672;D013505 | T040;T061 |
34,665,410 | evalu corpus callosum shape patient obstruct sleep apnea aim studi examin whether differ corpus callosum shape patient mild moder sever obstruct sleep apnea osa compar patient simpl snore | D020181;D012913 | T047;T184 |
34,665,402 | zebrafish experiment model huntington diseas molecular aspect therapeut target current challeng huntington diseas hd lethal autosom domin neurodegen diseas whose exact causat mechan still unknown transform one generat anoth generat cag triplet expans polyglutamin polyq tract huntingtin protein primarili contribut hd pathogenesi apart anoth molecular mechan also involv hd patholog loss brain deriv neurotroph factor medium spini neuron mitochondri dysfunct alter synapt plastic briefli discuss review howev sever chemic nitropropion acid quinolin acid genet mhtt n q express experiment model use explor exact pathogen mechan find new drug target develop novel therapeut approach zebrafish danio rerio wide use vivo screen sever central nervous system cns diseas hd alzheim diseas ad parkinson diseas pd memori deficit thus make zebrafish excel anim model develop new therapeut strategi various cns disord review sever public util zebrafish rodent explor diseas patholog studi suggest zebrafish gene human homologu conserv function zebrafish advantag characterist experiment anim make excel tool diseas studi review explain possibl pathogen mechan hd also discuss possibl treatment therapi apart also discuss possibl potenti therapeut target help design novel therapeut approach overcom diseas progress diagrammat depict show prevent hd pathogenesi attenu various biochem alter | D004195 | T050 |
34,665,400 | identif evalu appropri housekeep gene real time gene profil hepatocellular carcinoma cell cultur three dimension scaffold assess optim refer gene intern control target gene normal import quantit real time polymeras chain reaction rt qpcr three dimension cell cultur especi gene profil cancer cell complex microenviron polym scaffold provid deeper understand tumor function vivo | D054457 | T122 |
34,665,399 | christia vespertilioni extract induc antiprolifer apoptosi breast cancer mcf cell c vespertiliomi extract evalu antiprolif apoptosi effect breast cancer mcf cell | D017209;D049109 | T043;T116;T123 |
34,665,395 | case persist sever sequela covid infect potenti role sudden death depend stage diseas autopsi find covid may includ spectrum cardiopulmonari patholog includ alveolar hyalin membran format vascular thrombosi intracardiac thrombi identif covid posit deced absenc clinic histori reli primarili post mortem nasopharyng np oropharyng op swab real time polymeras chain reaction rt pcr absenc definit microbiolog test post mortem comput tomographi pmct may power adjunct tool screen persist patholog chang may prolong physiolog alter increas risk cardiopulmonari compromis current case outlin forens present util screen tool includ pmct autopsi find recent toxicolog relat sudden death case context sever sequela covid pneumonia case demonstr limit np op swab post mortem set valu pmct adjunct screen tool rais consider covid sequela potenti contribut risk factor sudden death case communiti | D000086382 | T047;T067 |
34,665,394 | two fatal case aceton cyanohydrin poison case report literatur review aceton cyanohydrin ach organ cyanid main use product methyl methacryl mma also exist cassava root main calori sourc tropic countri ach decompos spontan enzymat aceton high toxic hydrogen cyanid hcn potenti toxic contact given limit forens studi case report fatal ach poison avail herein present report two fatal case ach poison two victim postmortem cyanid blood concentr gml gml suffer acut poison ach due traffic accid furthermor literatur review cyanid poison case report carri subject cyanid poison present includ age sex caus poison autopsi find cyanid concentr blood ach poison lack specif reliabl autopsi find diagnosi relev toxicolog studi necessari due chemic properti ach allow easili decompos toxicolog analysi aceton cyanid biolog sampl essenti diagnosi ach poison | D011041 | T037 |
34,665,391 | knock cd astrocyt aggrav oxyhemoglobin induc hippocamp neuron impair subarachnoid hemorrhag sah one sever hemorrhag stroke close relat neuron damag neurogenesi promis therapi howev reliabl target current lack increas evid indic cd associ growth hippocamp neuron regul neural stemprecursor cell prolifer investig potenti effect cd astrocyt neuron growth hippocampus use transwel co cultur system hippocamp astrocyt neuron oxyhemoglobin oxyhb ad cultur medium mimic sah vitro specif lentivirus use knock cd express astrocyt verifi western blot quantit real time polymeras chain reaction immunofluoresc stain astrocyt activ neurit elong neuron apoptosi cell viabil also assess first determin augment express level cd hippocamp astrocyt sah similar result observ cultur astrocyt expos oxyhb correspond chang shperk also notic cd astrocyt downregul lentivirus led impair axon dendrit co cultur neuron aggrav neuron apoptosi induc cd downregul astrocyt might result lower level brain deriv neurotroph factor bdnf conclus knock cd astrocyt suppress hippocamp neuron growth shp erk signal pathway bndf possibl involv | D001253;D051927;D010108 | T025;T129;T116;T123 |
34,665,390 | chimer antigen receptor car cell therapi glioblastoma glioblastoma gbm common aggress primari brain tumor adult current mainstay treatment includ surgeri chemotherapi radiat howev ineffect result immunotherapi treatment strategi develop har bodi natur defens mechan glioma adopt cell therapi chimer antigen receptor car cell use patient cell genet modifi target tumor associ antigen cell harvest patient engin target specif protein express tumor inject patient goal destroy tumor cell mini review outlin histori car cell therapi describ current antigen target review challeng treatment face specif target gbm | D001932;D005909;D000076962 | T192;T191;T116;T129 |
34,665,388 | use optic stimul luminesc dosimet radiophotoliminesc glass dosimet dose measur dual sourc dual energi comput tomographi aim evalu properti optic stimul luminesc dosimet osld radiophotoluminesc glass dosimet rplds use dual sourc dual energi de comput tomographi dect dosimetri energi depend evalu singl energi se de mode relat dose respons differ equival effect energi osld rpld respect dose variat evalu use coeffici variat dose valu dosimet dose variat osld rpld se mode rang de mode respect dose linear evalu mgi linear relationship dose respons observ dosimet ionize chamber correl coeffici angular depend evalu smaller de mode se mode osld normal respons rpld higher lower se de mode studi demonstr osld rpld perform dosimetri dual sourc dect small influenc properti dosimet compar sect | D062791;D000072232 | T057;T073 |
34,665,387 | debri stimul tumor growth pandora box current cancer therapi aim erad cancer cell bodi howev kill cell generat cell debri promot tumor progress thus therapi doubl edg sword specif injuri debri generat cancer therapi includ chemotherapi radiat surgeri may offset benefit promot secret pro tumorigen factor eg eicosanoid driven cytokin stimul regrowth metastasi surviv cell debri produc cytotox cancer therapi also contribut tumor microenviron promot tumor progress recurr although well understood sever molecular mechan implic debri stimul tumor growth review involv extracellular vesicl exosom mir p bax bak smac hmgb cytokin caspas discuss case pancreat cancer type debri promot postop tumor recurr metastasi thus offer new opportun prevent cancer progress intrins link treatment stimul resolut tumor promot debri | D000970;D035683;D009369 | T191;T121;T109;T123;T114 |
34,665,386 | valid self assess wisdom scale saw iranian sampl psychometr development find studi aim investig valid factor structur self assess wisdom scale saw webster j adult dev iranian popul particip male femal recruit tehran iran rang age year cronbach alpha subscal rang inter correl rang exploratori factor analysi extract factor similar origin structur confirmatori factor analysi support factor model saw saw total subscal score posit correl two measur wisdom indic converg valid saw correl weak age women score higher saw subscal emot regul reminiscencereflect humor account signific gender differ total wisdom although age differ consist prior research gender differ relat novel overal result indic saw excel psychometr properti use cross cultur work | D011594 | T060 |
34,665,384 | school subcultur valu risk youth violenc influenc code street among student three us citi littl known role subcultur valu develop violenc school among school age children draw code street thesi identifi school import stage ground campaign respect among young peopl studi aim fill gap literatur analyz student school level associ project violenc self report subcultur valu revolv around tough respect analyt sampl includ n student femal grade age year mean year middl high school boston denver co miami fl consist research involv varieti adolesc young adult popul estim multilevel negat binomi regress model reveal robust posit student level associ person adher subcultur valu project violenc howev school level result indic composit rather contextu effect higher school mean level project violenc reflect aggreg valu individu student rather independ interact process involv school level preval code street valu thus code street valu may import contributor youth violenc school set appear play limit role transmit influenc among student | D012574;D013334 | T092;T098;T073;T081 |
34,665,383 | ethnic racial social ethnic racial ident depress symptom korean adolesc unit state china unit state china top two receiv countri korean immigr modern histori minor famili ethnic racial divers societi us china use various ethnic racial social practic cultur social promot mistrust prepar bias help children navig world yet research non us context scarc examin specif versus generaliz ethnic racial social implic studi compar preval ethnic racial social report korean american n age sd femal korean chines n age sd femal youth moreov studi examin various ethnic racial social practic relat youth ethnic racial ident subsequ depress symptom although korean american youth report frequent ethnic racial social compar korean chines counterpart cultur social prepar bias promot mistrust compar negat indirect associ depress symptom via ethnic racial ident across group thus although rate parent ethnic racial social context specif parent cultur social may similar benefici korean ethnic racial minor youth ident develop turn psycholog outcom whether western individualist societi eastern collectivist societi | D003863;D012951 | T065;T048;T184 |
34,665,382 | aftermath school victim link authorit school climat adolesc percept negat effect bulli victim although authorit school climat strict yet fair enforc rule alongsid strong adult support associ lower rate bulli victim less known whether influenc negat adolesc feel victim school unclear whether boy girl respond differ authorit climat identifi way school reduc negat feel bulli import given long term psycholog ramif bulli left unaddress extend adulthood address gap studi examin whether authorit school climat relat negat adolesc felt schoolwork relationship physic health self percept bulli differ boy girl also investig analys conduct use nation data school crime supplement sampl adolesc age year age year girl find set ordin regress model robust set student parent school control demonstr adolesc support school less like report bulli victim negat impact schoolwork feel similar result found girl boy invest support school climat school potenti transform place adolesc especi girl feel posit despit bulli | D000294;D058445;D019548 | T048;T068;T098;T055 |
34,665,381 | enhanc agon induc condit appetit sexual respons toward non reproduct conspecif brain mechan sexual attract toward reproduct partner develop systemat interrelationship biolog natur learn nurtur howev caus attract toward non reproduct partner poor understood explor role pavlovian learn dopaminerg agon develop sexual prefer brain activ young male rat condit adult sexual nave male receiv either salin salin pair receptor agonist quinpirol qnp pair cohabit conting conting qnp unpair h almond scent prepubert juvenil male pd condit occur everi day three trial social sexual respons assess four day last condit trial drug free test male chose freeli scent young male pd novel recept femal four day later male expos condit odor brain fos ir serum testosteron analyz salin pair qnp unpair male display non contact erect nces genit investig femal wherea qnp pair male express nces genit investig young male qnp pair group exposur young male pair odor evok fos ir limbic hypothalam cortic area differ serum testosteron observ cohabit juvenil male enhanc agon result atyp appetit sexual respons higher pattern brain respons young male pair odor chang serum testosteron discuss potenti implic develop pedophil disord perhap paraphilia | D018491;D012726 | T121;T054 |
34,665,380 | individu treat gender dysphoria medic andor surgic transit subsequ detransit survey detransition studi purpos describ popul individu experienc gender dysphoria chose undergo medic andor surgic transit detransit discontinu medic surgeri revers effect transit recruit inform link anonym survey share social media profession listserv via snowbal sampl sixti nine percent particip natal femal natal male reason detransit vari includ experienc discrimin becom comfort identifi natal sex concern potenti medic complic transit come view gender dysphoria caus someth specif trauma abus mental health condit homophobia difficulti accept lesbian gay bisexu express reason transit subsequ detransit major felt receiv adequ evalu doctor mental health profession start transit respond inform clinician detransit mani differ reason experi lead detransit research need understand popul determin preval detransit outcom transit meet medic psycholog need popul better inform process evalu counsel prior transit | D000068116;D018452;D000072339;D063106 | T048;T098;T055 |
34,665,379 | uniqu function notch murin embryon lymphangiogenesi mice embryon dermal lymphat develop well understood use studi gene function lymphangiogenesi notch signal evolutionarili conserv pathway modul cell fate decis shown inhibit promot dermal lymphangiogenesi demonstr distinct role notch signal versus canon notch signal embryon dermal lymphangiogenesi activ grow embryon dermal lymphat express notch notch dll correl notch activ lymphat endotheli cell lec dll activ notch induc subset notch effector lymphat gene distinct regul notch notch activ treatment lec vegf vegf c upregul dll transcript differenti tempor regul express notch heshey gene mice nullizyg notch increas closur lymphangiogen front correl reduc vessel calib matur lymphat plexus e reduc branch e activ notch suppress lec migrat wound assay signific notch suggest domin role notch regul lec migrat unlik notch null inhibit canon notch signal express domin negat form maml dnmaml prox lec led increas lymphat densiti consist increas lec prolifer describ loss lec notch moreov loss notch affect lec canon notch signal thus propos notch signal canon notch signal distinct function coordin embryon dermal lymphangiogenesi | D042583;D042601 | T039;T023 |
34,665,378 | examin mediat relationship communiti mobil hiv incid among young south african women particip hptn studi cohort previous demonstr villag communiti mobil cm associ reduc hiv incid among adolesc girl young women agyw south africa littl remain known mechan link cm hiv incid use longitudin data agyw hptn cohort examin whether school attend pro social engag hope futur mediat relationship cm hiv incid cm measur villag level via two popul base survey mediat incid hiv infect measur hptn survey hiv test mediat analys conduct use mplus adjust villag level cluster covari hope futur mediat relationship cm hiv incid indirect effect rr bias correct ci pro social engag school attend demonstr indirect effect cm reduc agyw hiv acquisit risk part engend hope | D015658 | T047 |
34,665,377 | product extracellular lipas psychrotroph bacterium oceanisphaera sp rsap isol arctic soil cold activ extracellular lipas produc differ psychrotroph import various industri applic isol gram negat rod shape aerob non pigment produc psychrotroph bacteri strain rsap mtcc mcc unexplor arctic soil sampl nyalesund svalbard norway n e detail morpholog biochem molecular characterist investig character isol rsap analys rdna sequenc strain rsap access mk show closest match oceanisphaera marina ym oceanisphaera sedimini tw jcm isol capabl produc extracellular lipas amylas cellulas ureas optim paramet lipas product found tributyrin base mll agar media supplement wv nacl day incub c temperatur ph shake condit purifi extracellular lipas rsap grown cultur supernat ammonium sulfat precipit follow dialysi deae cellulos column chromatographi invitro lipolyt activ purifi lipas enzym done zymogram analysi molecular weight found lipas kd optim activ purifi lipas found c ph maldi tof ms studi purifi lipas show highest match sequenc prolipoprotein diacylglyceryl transferas sequenc coverag studi larg scale product substrat util enzymat kinet lipas could unravel possibl futur biotechnolog applic | D008049;D012987 | T167;T116;T121;T126 |
34,665,376 | fast slow analysi techniqu understand neuron respons current ramp standard protocol studi spike properti singl neuron applic current step monitor voltag respons although inform jump appli current artifici physiolog input appli current ramp reflect chemosensori input unsurpris neuron respond differ two protocol sinc ion channel activ inactiv affect differ understand effect current ramp chang slope facilit mathemat model howev techniqu analyz current ramp develop articl demonstr current ramp analyz singl neuron model primari issu presenc gate variabl activ slow time scale therefor far equilibrium throughout ramp use appropri fast slow analysi techniqu allow one fulli understand neural respons ramp differ slope studi motiv data olfactori bulb dopamin neuron fast ramp ten millisecond slow ramp ten second protocol use understand spike profil cell slow ramp generat experiment bifurc diagram appli current bifurc paramet therebi establish asymptot spike activ pattern faster ramp elicit pure transient behavior relev physiolog input short durat two protocol togeth provid broader understand neuron spike profil role slowli activ ion channel play | D008959;D009474 | T025;T170 |
34,665,375 | role carbon anhydras iii autophagi type diabet cardio cerebrovascular diseas type diabet mellitus tdm one common chronic diseas among elder peopl tdm increas risk cardio cerebrovascular diseas ccd main patholog chang ccd atherosclerosi meanwhil carbon anhydras cas involv format progress plaqu howev exact physiolog mechan carbon anhydras iii caiii clear yet also correl studi caiii protein tdm ccd week old diabet mice dbdb mice wild type mice wt mice feed normal diet till week detect carotid arteri vascular open angl use method biomechan chang cerebr cortex myocardium watch ultrastructur autophagi observ electron microscop tissu structur inflamm cell injuri observ hematoxylin eosin stain apoptosi cell observ tunel stain protein level caiii il p detect immunohistochem western blot beclin lc nf b detect western blot statist analysi perform use prism softwar compar wt mice dbdb mice carotid arteri open angl increas signific electron microscop result indic autophagi dbdb mice cerebr cortex heart tissu decreas intracellular organell ultrastructur damag stain indic dbdb mice cerebr cortex heart tissu stain lighter inflammatori cell infiltr cell edema obvious myocardi fiber disord myocardi cell show differ degre degener compar wt mice tunel stain show obvious increas dbdb mice cortex heart tissu cell apoptosi result immunohistochemistri western blot indic caiii beclin lciii express level conspicu decreas cortex heart tissu dbdb mice express level il nf b p obvious increas carotid arteri vascular stiff increas probabl relat format diabet mice autophagi particip occurr develop diabet ccd caiii protein might somehow involv regul autophagi probabl affect cell apoptosi inflamm under mechan remain studi | D024403;D002561;D003921;D003924 | T116;T047;T050;T126 |
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