PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,665,373 | abnorm biorbit angl children infantil exotropia causat factor infantil exotropia unknown purpos studi investig relationship biorbit angl pathogenesi infantil exotropia | D005099 | T047 |
34,665,372 | retrospect review xen implant surgeri efficaci safeti effect combin cataract surgeri investig safeti efficaci glaucoma xen stent implant examin effect undergo combin phacoemulsif xen versus xen implant alon | D002386;D020327;D005902 | T190;T033;T074;T047 |
34,665,371 | refract chang post rotatori nystagmus healthi individu post rotatori nystagmus use detect autism spectrum disord clinic set although previous studi focus eye movement evalu chang ocular refract post rotatori nystagmus studi aim evalu chang ocular refract post rotatori nystagmus healthi individu | D012029;D014787 | T060;T201 |
34,665,370 | deep learn automat segment thigh leg muscl studi address automat segment select muscl thigh leg supervis deep learn approach | D000077321;D007091 | T066 |
34,665,369 | preval distinct type hardwar failur relat deep brain stimul deep brain stimul dbs effect treatment sever type neurolog condit includ parkinson diseas essenti tremor dystonia epilepsi despit technolog progress past year number studi report side effect dbs increas main due hardwar failur review investig studi publish identifi preval distinct type hardwar failur relat dbs total fifteen studi select estim preval five distinct type hardwar failur high imped fractur failur lead part implant skin eros infect lead malposit migrat implant puls generat ipg malfunct qualiti evalu studi suggest need report result includ popul distinct region world result general object analysi preval hardwar failur show skin eros infect present highest preval relat hardwar failur despit sophist surgic techniqu dbs time consider complic rate per individu formula see text ci confid interv futur research also includ correl analysi aim understand correl distinct hardwar failur variabl gender type disord age | D046690;D004421 | T184;T061 |
34,665,365 | morphometr analysi arabidopsi thaliana nuclei reveal characterist profil differ cell type access function chang cell upon development switch respons environment cue often reflect nuclear phenotyp show distinct chromatin state correspond transcript chang characterist nuclear shape microscop monitor quantifi differenti stain euchromatin heterochromatin domain examin sever nuclear paramet size dna content dna densiti chromatin compact relat heterochromatin fraction rhf number chromocent relat spatial distribut gene transposon element tes use standard fluoresc microscopi provid nuclear profil differ cell type differ access arabidopsi thaliana variabl yet signific fraction tes found outsid chromocent cell type except guard cell latter cell type featur nuclei highest level chromatin compact chromocent seem contain gene rich region highest number paramet correl found access cvi wherea ler show correl may point differ phenotyp robust access signific high associ chromocent access ws cvi correspond low rhf level | D017360 | T002 |
34,665,362 | impact mitomycin c induc neutropenia hypertherm intraperiton chemotherapi cytoreduct surgeri colorect cancer patient periton carcinomatosi mitomycin c mmc common use chemotherapeut agent hypertherm intraperiton chemotherapi hipec cytoreduct surgeri crs howev mmc side effect myelosuppress studi aim evalu clinic manifest impact mmc induc neutropenia crs hipec colorect cancer patient | D015179;D006979;D009503;D010534 | T191;T047;T061 |
34,665,361 | laparoscop extraperiton approach bilater pelvic lymph node dissect low rectal cancer techniqu video model later pelvic lymph node dissect rectal cancer difficult techniqu due complex pelvic anatomi recent seri underlin import later lymphadenectomi select patient prevent local recurr rectal cancer | D010535;D012004 | T061;T191;T060 |
34,665,357 | continu labor support person center matern care cross section studi women rural kenya studi assess whether continu support labor associ better person center matern care pcmc among women rural kenya | D008427 | T058 |
34,665,356 | health care access qualiti among children expos advers implic univers screen advers childhood experi given recent advanc toward univers screen advers childhood experi ace object investig whether children higher ace experi poorer qualiti provid care greater challeng access need mental health treatment | D000076783 | T033 |
34,665,355 | postpartum mental health rural south africa socioeconom stressor worsen mental health studi aim character pattern worsen mental health postpartum period among women rural area limpopo provinc south africa identifi correl household demograph factor | D019052;D008603 | T048;T041 |
34,665,354 | impact prosthesi patient mismatch late outcom bioprosthet mitral valv replac mitral regurgit negat impact prosthesi patient mismatch long term surviv valv replac report howev effect prosthesi patient mismatch bioprosthet mitral valv replac yet well examin purpos studi investig effect prosthesi patient mismatch late outcom bioprosthet mitral valv replac mitral regurgit total patient underw bioprosthet mitral valv replac april decemb exclud patient mitral stenosi incomplet data patient includ studi postop transthorac echocardiographi perform discharg patient effect orific area bioprosthet mitral valv calcul use formula pressur half time effect orific area index calcul formula effect orific areabodi surfac area prosthesi patient mismatch defin postop effect orific area index cm characterist outcom compar group patient prosthesi patient mismatch patient without prosthesi patient mismatch signific differ hospit mortal morbid multivari analysi show prosthesi patient mismatch independ predictor late mortal hazard ratio confid interv p death heart failur hazard ratio confid interv p prosthesi patient mismatch discharg mitral valv replac mitral regurgit associ long term mortal death heart failur | D006333;D006350;D019918;D008944 | T074;T047;T061;T046 |
34,665,352 | duplic exon matrin phenotyp bridg amyotroph later sclerosi immun mediat disord mutat matrin matr gene describ al suggest role gene diseas pathogenesi matr mutat point mutat report first case al associ duplic exon patient present limb onset al complex past medic histori sjgren syndrom antiphospholipid antibodi posit polyallergi endometriosi aldosteron secret adren cortic adenoma congenit vesicoureter reflux right breast hypoplasia discuss matr effect al role previous undescrib mutat peculiar al phenotyp associ system autoimmun involv | D000690 | T047 |
34,665,350 | silicon allevi antimoni phytotox giant reed arundo donax l silicon enhanc photosynthet effici biomass lignif root structur possibl limit antimoni transloc mitig phytotox giant reed plant antimoni sb non essenti metalloid caus toxic effect plant silicon report impart toler biotic abiot stress plant fast grow plant giant reed arundo donax l promis energi crop suitabl plant phytoremedi howev inform regard toler capac respect sb toxic potenti si mitig sb phytotox giant reed scarc rhizom giant reed grown ten week hydropon expos sb si combin wherein treatment without sbsi serv control effect treatment rate net photosynthesi photosynthet pigment phytoextract abil sb si sb uptak plant biomass lignif suber root along local sb si analys found si consider improv growth biomass giant reed sb toxic antimoni reduc photosynthesi decreas content photosynthet pigment complet allevi si silicon amend sb treat plant enhanc root lignif silicon enhanc lignif root structur probabl restrict sb transloc howev co local sb si observ neither shoot root level similar sb also detect leaf phytolith find suggest si treatment promot overal plant growth improv photosynthet paramet decreas sb transloc root shoot giant reed improv root lignif | D000965;D012825 | T131;T196 |
34,665,349 | fatti acid composit qualiti egg perform lay quail fed diet hesperidin studi investig effect hesperidin egg intern extern qualiti paramet fatti acid egg yolk nutrient content ad differ amount hesperidin quail diet total japanes quail coturnix coturnix japonica divid three group hesperidin group n control group hes hesperidin group hes hesperidin group hes five replic found analysi hesperidin affect weight thick shell extern qualiti paramet egg p term hes hes group weight egg increas compar hes group fractur resist shell decreas p egg intern qualiti paramet shown egg white width p yolk diamet p increas hes hes group length white decreas p found n linol acid n docosahexaeno acid fatti acid valu increas signific accord hesperidin dosag p paramet composit fatti acid egg result believ hesperidin ad diet general posit effect fatti acid composit intern extern qualiti paramet egg would appropri use feed addit | D005227;D006569 | T121;T109;T123;T168;T127 |
34,665,348 | evalu ultrastructur alter glomerular basement membran podocyt glomeruli low vacuum scan electron microscopi low vacuum scan electron microscopi lv sem appli diagnost renal patholog | D050533;D050199 | T025;T023 |
34,665,347 | role optic coher tomographi angiographi imag patient diabet ocular manifest patient diabet mellitus dm present microvascular chang microvascular chang challeng identifi exam imag technolog common aid diagnosi manag patient dm optic coher tomographi angiographi octa provid noninvas imag segment various layer retina choroid also post process imag associ quantit measur offer potenti clinic enhanc aim review current evid util octa patient dm | D003920;D003930;D008269 | T047 |
34,665,346 | physic activ idiopath inflammatori myopathi two intervent propos base literatur review idiopath inflammatori myopathi iim rare diseas affect skelet muscl lead progress muscl weak disabl thank better understand pathogenesi manag iim noteworthili implement recent year current therapeut strategi includ pharmacolog non pharmacolog intervent among physic exercis repres use option abl amelior diseas activ without worsen muscl inflamm aim narrat review therefor provid updat overview benefit physic exercis patient iim suggest plausibl train program appli patient dermatomyos polymyos necrot myopathi inclus bodi myositi regard combin strategi mix aerob resist exercis could posit affect pro inflammatori metabol pathway occur skelet muscl promot muscl fiber regener repair | D009220;D018979;D017285 | T047 |
34,665,345 | margin fit unit cad cam zirconia framework fabric use cone beam comput tomographi scan experiment studi whether cone beam comput tomographi cbct scan use fabric comput aid design comput aid manufactur cad cam fix dental prosthes fdps known purpos present studi compar margin fit unit zirconia fdps fabric use cbct dimension laboratori scan extract second premolar molar teeth maxillari typodont model prepar first molar remov typodont model scan laboratori cbct scanner generat two virtual cast group dl cbct forti four unit zirconia fdps design virtual cast mill vertic margin discrep vmd measur magnif microscopi seven locat abut total measur made fix locat two group specimen vmd data dl cbct group statist analyz use mann whitney u test mean vmds premolar rang median dl median cbct molar median dl median cbct signific differ gap dl cbct group p fdps fabric use laboratori scanner signific smaller vmds nevertheless unit zirconia fdps fabric use cbct scan present promis margin integr | D018772;D017267 | T170;T061 |
34,665,344 | experi expect brain plastic correspond cast specif abiot challeng dampwood termit zootermopsi angusticolli z nevadensi hypothes adapt brain invest predict associ relat size function distinct brain region sensorycognit demand anim confront measur development differ relat size visual process brain region optic lobe among dampwood termit cast test whether optic lobe invest match cast differ exposur visual complex environ wing primari reproduct kingsqueen mate flight cast leav dark nest caviti predict kingsqueen show greater relat invest optic lobe tissu nestbound neoten reproduct soldier two dampwood termit speci zootermopsi angusticolli z nevadensi relat optic lobe size span order magnitud among cast studi suggest growth optic lobe incur substanti tissu cost optic lobe growth experi expect optic lobe z angusticolli brachypter nymph typic develop kingsqueen relat larger optic lobe apter nymph preced neoten soldier relat optic lobe size nestbound brachypter nymph statist similar kingsqueen experi expect brain tissu growth rare document insect like entail high potenti cost tissu product mainten relat low immedi sensorycognit benefit develop hypothes condit experi expect growth brain region could favor natur select | D020049 | T204 |
34,665,341 | morphometr evalu dental arch children cleft lip palat submit differ surgic techniqu studi aim compar dimension alter dental arch children unilater complet cleft lip palat differ techniqu primari plastic surgeri | D002971;D002972 | T019 |
34,665,340 | oral health qualiti life peopl live human cell leukemia virus salvador brazil cross section studi compar oral health status oral health relat qualiti life ohrqol symptomat asymptomat patient human cell leukemia virus htlv | D015368;D015458 | T191;T005 |
34,665,338 | solar radiat induc synthesi bacteri cellulosesilv nanoparticl bcagnp composit use bc reduc cap agent present work simpl novel ecofriend method synthesi silver nanoparticl agnp bcagnp composit use bacteri cellulos bc nanofib soak agno solut induct action solar radiat photochem reduct silver ag ion silver nanoparticl ag confirm use uv visibl spectra surfac plasmon reson synthes agnp local around nm mean diamet agnp obtain dls analysi nm zeta potenti valu mv tem imag show spheric shape agnp format bcagnp composit confirm fesem edx ftir xrd analysi fesem imag bc show structur bc nanofib deposit agnp bc crystallin nanofib xrd measur reveal high crystallin bc bcagnp composit crystal size nm respect bcagnp composit agnp exhibit strong antibacteri activ gram posit gram negat bacteria present work introduc facil green approach bcagnp composit synthesi util potenti food packag wound dress well sunlight indic applic | D053768;D012834 | T196;T073 |
34,665,336 | overcom resist target therapi use met inhibitor solid cancer evid preclin clinic studi target therapi hallmark cancer treatment chang landscap cancer manag enabl person treatment approach nevertheless develop cancer resist major challeng current threaten effect util target therapi hepatocyt growth factor receptor met receptor tyrosin kinas known oncogen activ tumorigen potenti met well known driver cancer resist grow bodi evid reveal major role met mediat acquir resist sever class target therapi deregul met common associ develop cancer resist includ gene amplif overexpress autocrin activ crosstalk signal pathway small molecul tyrosin kinas inhibitor met current approv treatment differ solid cancer review summar current evid regard met mediat cancer resist toward target therapi molecular mechan associ resist describ along find preclin clinic studi use met inhibitor restor anticanc activ target therapi treatment solid tumor | D058990 | T061 |
34,665,332 | compar plastid genom mazacea focus new recogn genus puchiumazus six mazacea plastom assembl studi includ newli recogn genus puchiumazus compar plastid genom analysi provid new insight mazacea phylogenet categor mazus lanceifolius mazacea long uncertain scholar bo li g zhang c l xiang republish lanceifolius new speci puchiumazus lanceifolius within new genus puchiumazus howev littl plastom inform mazacea follow publish new genus puchiumazus necessari studi mazacea plastom featur comprehens understand young famili mazacea plastom typic quartil structur plastom size rang bp plastom contain uniqu gene includ protein code gene rrna gene trna gene compar analysi show plastom sequenc high conserv furthermor identifi four relat hypervari region trnq uuc psbk trns gcu trns cga trnt ugu trnl uaa ycf use potenti dna barcod identif clade phylogenet relationship base whole plastom sequenc sampl genera lamial place lanceifolius basal clade famili mazacea bootstrap support summari lanceifolius result indic new monotyp genus puchiumazus establish whole plastom level studi provid plastid genom resourc explor phylogeni mazacea | D019143;D000068378 | T002;T038 |
34,665,331 | qualiti life individu newli diagnos multipl sclerosi clinic isol syndrom littl known qualiti life qol time multipl sclerosi ms clinic isol syndrom cis diagnosi evolv critic adjust period immedi follow new diagnosi | D003711;D009103 | T047;T046 |
34,665,330 | opinion knowledg clinic experi function neurolog disord among italian neurologist result onlin survey function neurolog disord fnd disabl medic condit common seen neurolog practic neurologist play essenti role manag fnd establish diagnosi coordin multidisciplinari team base treatment patient studi investig knowledg clinic experi italian neurologist manag patient fnd | D003291;D009422 | T048;T047 |
34,665,329 | baselin mri atrophi predict year cognit outcom earli onset alzheim diseas mri atrophi predict cognit status ad howev relationship investig earli onset ad eoad year patient biomark base diagnosi | D000544;D060825 | T048;T047 |
34,665,328 | function role ant temper grassland ant temper grassland consum ecosystem engin influenc biodivers potenti grassland product howev effect ant exclus suppress resourc remov biolog communiti temper grassland yet fulli explor conduct ant suppress experi evalu effect ant ground dwell arthropod communiti field use pitfal bait trap laboratori evalu effect ant ant attend aphid aphi rumici honeydew resourc ant slug derocera laev aphid predat aboveground arthropod communiti affect ant suppress treatment howev slug laev ambigolimax valentianus visit bait resourc frequent ant suppress treatment area ant absenc condit laboratori experi fewer aphid plant compar ant presenc condit owe predat laev result suggest ant abund temper grassland influenc predat activ slug toward honeydew sourc aphid | D001000;D001042 | T204 |
34,665,327 | sarcopenia pulmonari diseas associ elev sarcoplasm reticulum stress myonuclear disorgan chronic obstruct pulmonari diseas copd frequent associ age relat muscl loss sarcopenia howev exact molecular mechan muscl loss copd remain elus investig associ chronic dysregul sarcoplasm reticulum sr protein homeostasi condit call sr stress myonuclear disorgan sarcopenia patient copd marker sr stress downstream consequ includ apoptosi inflamm upregul patient copd maxim sr ca atpas serca activ signific reduc advanc copd compar healthi control singl muscl fiber diamet cytoplasm domain per myonucleus signific smaller patient advanc copd healthi control increas disrupt myonuclear organ found copd patient compar healthi control chang sr dysfunct accompani elev global level oxid stress includ lipid peroxid mitochondri reactiv oxygen speci ros product altogeth data suggest muscl weak advanc copd part associ disrupt sr protein calcium homeostasi patholog consequ | D008171;D055948 | T047 |
34,665,326 | parachut techniqu portal vein reconstruct pancreaticoduodenectomi portal vein resect patient pancreat head cancer appropri venous reconstruct method remain debat long section portal vein pv andor superior mesenter vein smv must resect patient undergo pancreaticoduodenectomi pd aim present studi describ technic detail parachut techniqu modifi end end anastomot maneuv use mention circumst investig safeti feasibl | D010190;D016577 | T191;T061 |
34,665,325 | postop aggress diuresi prevent postop tissu edema complic patient undergo distal pancreatectomi intraop fluid restrict report associ reduc postop tissu edema decreas incid postop pancreat fistula popf pancreat surgeri howev limit inform regard postop approach prevent postop tissu edema reduc popf | D010180;D010185 | T047;T061 |
34,665,324 | infect accid nurs overtim neonat intens care unit paper investig effect nurs overtim nosocomi infect medic accid neonat intens care unit nicu literatur lack clear evid issu conjectur may due empir methodolog factor model occurr event use sampl neonat repres observ infantday exploit import chang workforc arrang implement june aim reduc overtim hour identifi causal impact latter two outcom interest contrast result use standard mix effect logit model semiparametr mix effect logit model contrari mix effect logit model semiparametr model unequivoc show advers event impact nurs overtim well high sensit infant nicu relat characterist furthermor mix effect logit model reject favour semiparametr one | D003428;D007363 | T047;T093;T073 |
34,665,323 | converg forepaw somatosensori motor cortic project striatum claustrum thalamus pontin nuclei cat basal ganglia pontocerebellar system regul somesthet guid motor behavior receiv promin input sensorimotor cortex addit claustrum thalamus forebrain subcort structur connect somatosensori motor cortic previous studi rat shown primari secondari somatosensori cortex send overlap project neostriatum pontin nuclei wherea overlap primari motor cortex much weaker addit shown project claustrum rat goal current studi compar rodent project pattern connect cat mammalian speci evolv separ phylogenet superord three differ anterograd tracer inject physiolog identifi forepaw represent cat label fiber termin throughout ipsilater striatum caudat putamen claustrum thalamus pontin nuclei digit reconstruct tracer label allow us quantifi normal distribut label subcort area tracer inject well amount tracer overlap surpris contrast previous find rodent observ project converg promin striatum pon wherea overlap much weaker furthermor wherea rat project claustrum confirm dens claustral input cat find suggest basal ganglia claustrum pontocerebellar system rat cat evolv distinct pattern sensorimotor cortic converg | D009044 | T023;T029 |
34,665,319 | clinic characterist sarcoidosi patient self report lymphoma us nationwid registri studi littl known associ sarcoidosi lymphoma aim determin preval lymphoma us sarcoidosi patient compar clinic characterist patient without lymphoma | D008223;D012507 | T191;T047 |
34,665,318 | behind mask extend use surgic mask associ increas risk surgic site infect covid prompt signific polici chang critic attent conserv person protect equip ppe extend surgic mask use polici implement institut allow use one dispos mask per individu per day case investig clinic impact polici chang effect rate day surgic site infect ssi | D000086382;D008397 | T074;T047;T067 |
34,665,317 | arteri involv resect score system predict r resect patient pancreat ductal adenocarcinoma treat neoadjuv chemoradi therapi deriv ct base score system incorpor arteri involv resect status predict r resect patient pancreat ductal adenocarcinoma pdac undergo neoadjuv chemoradi therapi crt | D021441;D010190 | T191 |
34,665,316 | comput tomographi complement ultrasound differenti diagnosi traumat neuroma recurr tumor patient postop thyroid cancer traumat neuroma tns mimic recurr tumor us total thyroidectomi tt later neck dissect lnd thyroid cancer aim evalu whether ct could complement us differenti diagnosi tns recurr thyroid cancer dissect neck | D009463;D013964 | T191 |
34,665,315 | mri base radiom clinic nomogram overal surviv predict patient hypopharyng squamous cell carcinoma multi cohort studi explor whether radiom featur extract pre treatment magnet reson imag mri predict overal surviv os patient hypopharyng squamous cell carcinoma | D006258;D049451 | T191;T170;T081 |
34,665,313 | edit aminocyclopropan carboxyl oxidas gene negat affect petunia seed germin edit aco gene involv ethylen biosynthesi pathway reduc ethylen product petunia seed inhibit seed germin ethylen product seed petunia hybrida cv mirag rose associ express aminocyclopropan carboxyl acid acc oxidas aco gene phaco phaco phaco suppress express ethylen inhibitor silver thiosulph sts signific reduc ethylen product inhibit seed germin combin ethylen precursor acc ethylen product promot via activ gene higher seed germin restor confirm use mutant edit gene wt present studi compar wild type plant three differ mutant phaco phaco phaco show signific decreas germin percentag well delay germin time seedl growth reduct associ lighter seed weight lower aco transcript level lower ethylen product mutant inhibit seed germin owe reduc ethylen product verifi supplement exogen acc gibberel acid ga growth medium restor high seed germin activ mutant via enhanc ethylen product studi report key regulatori role ethylen seed germin mechan petunia highlight need consid negat effect ethylen reduct seed germin plant growth edit gene ethylen biosynthesi pathway mainten postharvest fruit veget flower qualiti | D000072669 | T063 |
34,665,311 | multin associ support care cancer mascc expert opinionguid use clinic assist nutrit patient advanc cancer pro vision clinic assist nutrit patient advanc cancer controversi pauciti specif guidanc divers clinic practic consequ palliat care studi group multin associ support care cancer mascc form subgroup develop evid base guidanc use patient advanc cancer | D005104;D009369 | T097;T191;T057;T077 |
34,665,309 | acut kidney injuri within enhanc recoveri surgeri era program colorect surgeri aim determin preval risk factor outcom acut kidney injuri aki within era program colorect surgeri crs | D058186;D003107;D000080482 | T091;T061;T047;T037 |
34,665,308 | cestod genom era first cestod genom obtain intern consortium led wellcom sanger institut includ repres institut countri sequenc parasit studi decad part etiolog agent endem diseas argentina uruguay mexico canada uk germani switzerland ireland usa japan china sever complet genom obtain reach speci date cestod genom smaller relat size compar anim includ free live flatworm moreov featur genom size repeat content seem differ two analyz order cyclophyllidean speci smaller genom fewer repetit content diphyllobothriidean speci averag cestod genom gene exon per gene gc content share cestod protein accur annot integr gene predict transcriptom evid protein unknown function sever gene loss reduct gene famili found could relat extrem parasit lifestyl speci applic cut edg sequenc technolog allow character termin sequenc chromosom possess uniqu characterist review current status knowledg complet cestod genom place within compar genom perspect multidisciplinari work togeth implement new technolog provid valuabl inform certain improv chanc final erad least control diseas caus cestod | D002589;D002590;D010986 | T204;T047 |
34,665,306 | suprasellar arachnoid cyst due ectop choroid plexus case report arachnoid cyst ac malform account intracrani lesion aetiolog progress lesion debat one possibl explan product cerebro spinal fluid csf ectop choroid plexus cp knowledg seven case ac incorpor cp report believ first report case suprasellar ac contain ectop cp year old boy present development delay macrocephali mri scan reveal hydrocephalus due suprasellar ac endoscop ventriculocisternostomi undertaken intra oper intra cystic pink frond like tissu resembl choroid plexus identifi histolog cyst wall compos fibrous tissu layer arachnoid cell frond like tissu compos papillari structur keep normal choroid plexus tissu postul rest ectop cp may trap within doubl layer arachnoid fold diencephal leaf liliequist membran may drive format develop certain suprasellar ac | D016080;D006849 | T033;T047;T019 |
34,665,305 | lncrna tlr suppress mir matur hepatocellular carcinoma suppress cell prolifer migrat tlr character oncogen lncrna ovarian cancer role hepatocellular carcinoma hcc unknown studi aim explor role tlr hcc tlr express hcc pair non tumor tissu hcc patient determin rt qpcr prognost valu tlr hcc analyz perform year follow correl tlr matur mir mir precursor analyz pearson correl coeffici role tlr mir regul prolifer migrat explor cck assay transwel migrat assay found tlr upregul hcc predict poor surviv across hcc tissu tlr invers correl matur mir mir precursor hcc cell tlr overexpress downregul matur mir mir precursor cell prolifer transwel migrat assay show tlr overexpress reduc enhanc effect mir cell prolifer migrat tlr may suppress mir matur hcc suppress cell prolifer migrat | D006528;D008113;D035683;D062085 | T191;T114;T123 |
34,665,303 | model singl cell cancer transform use phase transit theori applic avrami equat nucleat growth theori describ avrami equat also call johnson mehl avrami kolmogorov equat usual use describ crystal nucleat process condens matter physic appli present paper cancer physic enhanc popular multi hit model carcinogenesi volumetr process singl cell dna neoplast transform present approach assum transform system dna chain includ mani oncogen mutat final probabl function cell cancer transform direct relat number oncogen mutat creat univers sigmoid probabl function cancer transform singl cell observ kinet nucleat growth special case phase transit process propos model repres differ view multi hit carcinogenesi approach test clinic data concern gastric cancer result also show cancer transform follow dna fractal geometri | D004247;D009369 | T191;T114;T123 |
34,665,301 | low skelet muscl mass assess direct rd cervic vertebra predict pharyngocutan fistula risk total laryngectomi male popul skelet muscl mass smm loss sarcopenia identifi risk factor postop complic aim studi investig relationship pharyngocutan fistula pcf format total laryngectomi tl smm assess comput tomographi imag rd cervic vertebra c | D017577;D007822;D010608 | T190;T191;T047 |
34,665,300 | strength interfer screw fixat meniscus prosthesi match nativ meniscus attach menisc surgeri one common orthopaed surgic intervent total meniscus replac propos solut patient irrepar menisc injuri reliabl fixat crucial success function implant aim studi characteris interfer screw fixat system develop novel fibr matrix reinforc synthet total meniscus replac ovin cadaver model | D059549;D000072600 | T023;T061 |
34,665,299 | arthroscop confirm femor button deploy prevent soft tissu interposit acl reconstruct purpos studi determin whether direct arthroscop control femor button prevent improp deploy soft tissu interposit anterior cruciat ligament acl reconstruct | D000070598;D059549;D001170 | T061;T047;T037 |
34,665,298 | caus irrit contact dermat occup skin exposur systemat review irrit contact dermat icd major caus occup diseas aim review relat exposur occup irrit icd prognosi icd | D017449;D003876;D017453;D009783;D016273 | T047;T037 |
34,665,291 | head neck tumor cell treat hypofraction irradi die via apoptosi better taken like macrophag incid head neck squamous cell carcinoma hnscc increas worldwid especi trigger human papilloma virus hpv radiotherapi immun modulatori properti role macrophag present hnscc contact irradi tumor cell remain unclear influenc irradi gy hnscc cell polar phagocytosi human macrophag either non polar phenotyp therefor investig | D006258;D008264 | T025;T191 |
34,665,288 | premenopaus women idiopath osteoporosi lower bone format rate associ higher bodi fat higher igf examin serum igf premenopaus iop find relationship opposit expect higher igf associ lower bone format higher bodi fat lower bmd respons teriparatid paradox relationship serum igf bone fat may contribut mechan idiopath osteoporosi premenopaus women | D050071;D010024 | T047;T121 |
34,665,287 | ad valu full reduc field view appar diffus coeffici map evalu extramur venous invas rectal cancer investig ad valu quantit analysi full reduc field view appar diffus coeffici fadc radc map evalu extramur venous invas emvi rectal cancer | D012004 | T191 |
34,665,285 | longitudin trend bodi mass index adult congenit heart diseas obes modifi independ risk factor advers long term outcom children adult object determin preval overweight obes status cohort adult congenit heart diseas chd well assess longitudin trend year period studi group consist patient year age older follow adult chd clinic bodi mass index bmi data collect index period consist patient encount period well period period avail studi cohort subdivid three group per publish guidelin simpl moder greater chd complex preval obes overweight status compar among differ group well publish data nhane cohort period consist subject median age interquartil rang period year bmi kgm underweight normal weight overweight obes patient follow data time period patient moder greater complex chd combin percentag overweight obes patient moder greater complex chd group increas period period respect percentag obes patient moder greater chd complex increas respect period studi cohort high preval overweight obes weight status given adult chd high baselin cardiovascular morbid presenc obes increas risk poor outcom highlight need prevent modifi risk factor | D006330;D050177 | T033;T019 |
34,665,284 | periop manag platelet function anticoagul geriatr patient geriatr patient often cardiovascular diseas requir differenti periop manag hemostasi oper relat bleed risk individu thromboembol risk mutual influenc differenti preoper assess prescript coagul modul medic requir mani case activ coagul medic interrupt without replac continu unchang cardiovascular diseas antiplatelet medic preoper risk benefit assess oper lead continu previous platelet aggreg inhibitor monotherapi howev high risk cardiovascular thromboembol dual platelet inhibit individu periop medic close coordin geriatrician cardiologistin case intak vitamin k antagonist vka preoper interrupt case high risk thromboembol temporari bridg heparin must carri introduct four new direct oral antagonist doac made periop manag anticoagul much easier bridg heparin necessari periop dosag time interrupt doac determin individu depend oper bleed risk well age bodi weight kidney function patient bleed complic aris influenc doac antidot avail three four doac acut case use addit prothrombin complex concentr fresh frozen plasma normal coagul | D000925;D013923 | T046;T121 |
34,665,282 | fluid manag shock patient new target initi phase shock earli iv fluid administr cornerston modern therapi shock especi septic shock howev much uncertainti concern amount rate fluid goal measur could guid fluid manag administ optim fluid volum import fluid overload lead sever negat consequ like organ failur worsen patient outcom | D018805;D012772 | T047;T046 |
34,665,281 | use extracorpor circul eclsecmo cardiac circulatori failur short version guidelin germani remark increas regard usag extracorpor membran oxygen ecmo extracorpor life support ecl system observ recent year approxim eclsecmo implant annual sinc despit widespread use eclsecmo evid base recommend guidelin still lack regard indic contraind limit manag ecmoecl patient therefor german societi thorac cardiovascular surgeri gstcvs regist multidisciplinari guidelin use extracorpor circul eclsecmo cardiac circulatori failur develop evid base recommend ecmoecl system accord requir associ scientif medic societi germani awmf although clinic applic ecmoecl repres main focus present guidelin also address structur econom issu expert german austrian swiss scientif societi patient organ guid gstcvs complet project februari report present summari methodolog concept tabl display recommend chapter guidelin | D015199;D012769 | T046;T061 |
34,665,280 | extracellular vesicl releas uptak liver normo hyperlipidemia liver play central role elimin circul extracellular vesicl ev also signific contribut ev releas howev involv differ liver cell popul remain unknown investig ev uptak releas normolipemia hyperlipidemia cbl mice kept high fat diet week circul ev profil determin addit control mice intraven inject tc hynic duramycin label ev hour later biodistribut analyz spectct vitro isol liver cell type test ev releas uptak withwithout prior fatti acid treatment detect elev circul ev number high fat diet clarifi differenti involv liver cell type carri vitro experi found increas releas ev primari hepatocyt concentr fatti acid compar characterist hyperlipidemia investig ev biodistribut tc label ev detect ev accumul primarili liver upon intraven inject mice medium nm small ev nm vitro found medium small ev preferenti taken kupffer cell liver sinusoid endotheli cell respect final demonstr hyperlipidemia decreas ev uptak kupffer cell liver sinusoid endotheli cell data suggest hyperlipidema increas releas reduc uptak ev liver cell also provid evid size depend differenti ev uptak differ cell type liver ev radiolabel protocol use tc duramycin may provid fast simpl label approach spectct imag ev biodistribut | D004195 | T050 |
34,665,278 | ferment profil microbi divers temper grass silag inocul epiphyt microbiota tropic grass studi design evalu effect epiphyt microbiota italian ryegrass irir napier grass irnp sudan grass irsd ensil characterist microbi communiti italian ryegrass silag treatment prepar triplic ensil plastic bag silo day ray irradi steril method microbiota transplant next generat sequenc technolog use result indic signific p higher ratio lactic acid acet acid lower acet acid ammonia nitrogen content observ irnp irir irsd day ensil lactobacillus predomin treatment late stage ferment lactococcus eventu replac lactobacillus irsd wherea higher abund lactococcus continu found irnp co occurr network analysi demonstr lactococcus pivot determin silag ferment pattern italian ryegrass accord rrna gene predict function profil metabol amino acid enhanc epiphyt microbiota italian ryegrass sudan grass carbohydr metabol acceler epiphyt microbiota napier grass overal irnp homo ferment process wherea irir irsd possess hetero ferment pattern lactococcus heterofer lactobacillus main respons also confirm exogen microorgan promot carbohydr metabol inhibit metabol amino acid could good potenti sourc improv silag qualiti temper grass | D064307;D045868 | T032;T001;T002;T028 |
34,665,277 | support vector machin base spontan intracrani hypotens detect brain mri develop fulli automat algorithm magnet reson imag mri identif patient spontan intracrani hypotens sih | D019585;D060388 | T047;T066;T081 |
34,665,276 | overview bioremedi tool organophosphorus hydrolas signific applic food environment therapi field past decad organophosphorus compound wide use environ food industri pesticid owe life threaten long last problem organophosphorus insecticid op effect detect remov op garner grow attent scientif practic field recent year bacteri organophosphorus hydrolas oph extens studi due high specif activ op oph could effici hydrolyz broad rang substrat includ op pesticid nerv agent suggest great potenti remedi op review microbi identif molecular modif practic applic oph comprehens discussedkey point microbi oph signific bioremedi tool op identif molecular modif oph discuss detail applic oph food environment therapi field present | D007306;D010575 | T131 |
34,665,275 | somatostatin receptor imag ga ga dotat positron emiss tomographycomput tomographi petct patient nasopharyng carcinoma explor feasibl ga ga dotat positron emiss tomographycomput tomographi petct patient non keratin nasopharyng carcinoma npc evalu whether ga ga dotat petct could use non invas determin somatostatin receptor sstr express npc | D009303;D009942 | T191;T109 |
34,665,272 | high burden diseas patient anca associ vascul claim data studi germani antineutrophil cytoplasm antibodi anca associ vascul aav repres group rare chronic autoimmun diseas character recurr system inflamm provok multipl morbid aav patient suffer various organ manifest treatment relat sever advers effect retrospect studi investig concret burden aav diseas patient germani | D056648;D055953 | T047 |
34,665,271 | inhibitor class hdac flt combin synergist leukemia cell mutant flt acut myeloid leukemia aml mutat fms like tyrosin kinas flt clinic unresolv problem aml cell frequent dysregul express activ epigenet modul histon deacetylas hdac famili therefor test whether combin inhibit mutant flt class hdac effect aml cell low nanomolar dose flt inhibitor flti ac inhibit class hdac nanomolar concentr fk micromolar dose hdac specif agent rgfp synergist induc apoptosi aml cell carri hyperact flt intern tandem duplic flt itd occur leukem cell wild type flt without flt suggest preferenti toxic combin cell mutant flt moreov nanomolar dose new flti marbotinib combin favor fk leukem cell flt itd combinatori treatment potenti suppress effect tyrosin phosphoryl stabil flt itd downstream signal kinas erkerk induc transcript factor stat benefici pro apoptot effect flti hdaci leukem cell mutant flt associ dose drug depend alter cell cycl distribut dna damag link modul tumor suppress transcript factor p target cyclin depend kinas inhibitor p hdaci induc p ac suppress express p p furthermor show flt itd class hdac activ promot express checkpoint kinas chk wee thymidyl synthas dna repair protein rad leukem cell genet deplet hdac attenu express protein thus class hdac hyperact flt appear valid target aml cell mutant flt | D015470 | T191 |
34,665,270 | neurosyphili disguis neurosyphili mimic differ diseas clinic present also imag treponema pallidum also known great imit ultim diagnosi neurosyphili quit critic affect manag drastic herein discuss case year old femal treat neurosyphili atyp imag find anterior tempor lobe enhanc simul infect herp simplex virus hsv also review avail literatur differ imag find earli late stage diseas | D009494 | T047 |
34,665,269 | influenc renal impair neurolog outcom follow mechan thrombectomi acut vertebrobasilar stroke renal impair ri regard risk factor unfavor neurolog outcom mechan thrombectomi mt acut ischem stroke howev previous studi conduct patient anterior circul stroke accord influenc ri mt outcom well elucid detail acut vertebrobasilar stroke | D000083242;D020521;D014715 | T047 |
34,665,268 | sexual behavior prevent sexual transmit infect take sar cov pandem account data sexual healthcar medicin center wir applic base data regard sexual health sexual behavior various sexual activ popul scarc time relev regard prevent healthcar suppli strategi given structur attende walk ruhr wir center sexual health medicin abl obtain data divers live environ | D000086382;D015658;D012749 | T047;T067 |
34,665,266 | use extracorpor circul eclsecmo cardiac circulatori failur short version guidelin germani remark increas regard usag extracorpor membran oxygen ecmo extracorpor life support ecl system observ recent year approxim eclsecmo implant annual sinc despit widespread use eclsecmo evid base recommend guidelin still lack regard indic contraind limit manag ecmoecl patient therefor german societi thorac cardiovascular surgeri gstcvs regist multidisciplinari guidelin use extracorpor circul eclsecmo cardiac circulatori failur develop evid base recommend ecmoecl system accord requir associ scientif medic societi germani awmf although clinic applic ecmoecl repres main focus present guidelin also address structur econom issu expert german austrian swiss scientif societi patient organ guid gstcvs complet project februari report present summari methodolog concept tabl display recommend chapter guidelin | D015199;D012769 | T046;T061 |
34,665,265 | enhanc stripe rust resist obtain combin yr wide dispers consist qtl chromosom arm bl yrfdc pbcfdc co segreg chromosom bl signific interact yrpbc enhanc stripe rust resist promot pseudo black chaff develop cultivar durabl resist popular mean control wheat stripe rust durabl resist achiev stack multipl adult plant resist apr gene individu relat small effect chines wheat cultivar ruihua rh fengdecun fdc confer partial apr stripe rust across environ one hundr seventi recombin inbr line cross rh fdc use determin genet basi resist identifi genom region associ stripe rust resist genotyp carri use k snp array eight quantit trait loci qtl detect chromosom arm al ds bs bl bl bl inclus composit interv map qyrnwafu bs rh qyrnwafu bl name yrfdc conveni fdc consist across four test environ qyrnwafu bs like pleiotrop resist gene sryr yrfdc map cm interv correspond mb flank snp marker ax ax line harbor yr yrfdc display higher resist parent express pseudo black chaff pbc control loci pbc pbcfdc co segreg yr yrfdc respect marker base pedigre base kinship analys reveal yrfdc inherit founder parent zhou b fifti four wheat cultivar share yrfdc haplotyp result suggest effect pyramid strategi acquir high effect durabl stripe rust resist breed | D032461;D017343 | T026;T028 |
34,665,261 | genic select within prokaryot pangenom understand evolutionari forc shape prokaryot pangenom structur major goal microbi evolut research recent work highlight substanti proport accessori gene appear confer nich specif adapt work primarili focus select act level individu cell herein discuss lower level select also contribut pangenom variat genic select refer case genet element rather individu cell entiti select clearest exampl form select selfish mobil genet element either neutral deleteri effect host fit review major class mobil element discuss characterist featur element could genic select also discuss genet element benefici host also genic select scenario may preval wide appreci disentangl effect select differ level ie organ vs gene challeng nonetheless appreci potenti action implic genic select import better understand evolut prokaryot pangenom | D019143;D011387 | T001;T038 |
34,665,258 | evalu sever delay graft function kidney transplant recipi common definit delay graft function dgf reli dialysi first week post transplant consid dgf sever impact dgf sever long term graft outcom remain controversi | D051799;D016030 | T046;T061 |
34,665,257 | graph represent learn structur proteom field structur proteom focus studi structur function relationship protein protein complex experienc rapid growth sinc earli structur databas protein data bank store increas amount protein structur data addit model structur becom increas avail combin recent advanc graph base machin learn model enabl use protein structur data predict model goal creat tool advanc understand protein function similar use graph learn tool molecular graph current undergo rapid develop also increas trend use graph learn approach protein structur short review paper survey studi use graph learn techniqu protein examin success shortcom also discuss futur direct | D000069550;D040901 | T091;T066 |
34,665,255 | avoid behavior guava leaf volatil oil three medic import mosquito vector volatil organ compound various plant receiv popular interest one vector control tool due eco friendli insect repel activ studi excito repel assay system use examin noncontact repel contact excit knockdown kd effect guava leaf psidium guajava l oil anophel minimus theobald anophel epiroticus linton harbach culex quinquefasciatus say organ compon guava oil identifi gas chromatographi mass spectrometri analysi dl limonen cymen terpinen major constitu concentr escap minimus record contact assay escap noncontact assay guava oil stimul potent irrit escap repel escap effect cx quinquefasciatus lower repel action observ epiroticus escap kd effect observ guava oil minimus cx quinquefasciatus concentr howev epiroticus prone kd effect highest percentag kd nonescap group observ guava oil noncontact assay mortal observ epiroticus nonescap group contact noncontact assay respect concentr guava oil led mortal minimus find highlight guava oil promis plant base mosquito repel includ insecticid formul futur mosquito control program | D000330;D003465;D007302;D007306;D009822;D031647 | T002;T109;T168;T131;T204 |
34,665,254 | dietari intak fatti acid risk pancreat cancer case control studi epidemiolog find dietari fat intak risk pancreat cancer panc inconsist | D005227;D010190 | T191;T168;T109;T123 |
34,665,253 | dynam mitochondri autophagi initi stage pathway mitochondri specif autophagi mitophagi defin specif elimin mitochondria follow distinct mitochondri injuri developmentalmetabol alter import health diseas review focuss earliest step pathway concern mechan requir initi autophagosom format mitochondri target specif view fact understand basic mechan non select autophagi begin reshap knowledg toward pathway select autophagi two aspect mitophagi cover machineri normal work associ endoplasm reticulum er make autophagosom also site distinct er surfac target cargo ii machineri deal cargo multipl size | D063306 | T043 |
34,665,251 | strateg trait bacteria archaea vari wide within substrat use group quantit trait maximum growth rate cell radial diamet one facet ecolog strategi variat across bacteria archaea anoth facet substrat use pathway iron reduct methylotrophi ask two facet intersect use larg compil data cultur speci examin seven quantit trait genom size signal transduct protein count histidin kinas count growth temperatur temperatur adjust maximum growth rate cell radial diamet rrna operon copi number overal quantit trait variat within group organ possess particular substrat use pathway broad outweigh differ substrat use group although substrat use group signific differ mean quantit trait standard deviat quantit trait valu within substrat use pathway most averag time larger standard deviat across group mean like wide variat reflect ecolog strategi exampl fast maximum growth rate like express earli succession copiotroph strategi maximum growth vari wide within substrat use pathway general appear quantit trait express differ complementari inform ecolog strategi compar substrat use | D001105;D001419 | T194;T007 |
34,665,250 | extracellular domain transmembran protein defi express level evolutionari rate anticorrel high express protein tend evolv slowli trend known express level rate evolut e r anticorrel wherea reason anticorrel remain unclear influenti hypothes attribut high express protein subject strong select pressur avoid misfold andor misinteract accord hypothes work laboratori recent shown extracellular secret protein lack e r anticorrel exhibit weaker usual e r anticorrel extracellular protein fold insid endoplasm reticulum enhanc qualiti control fold mechan exist function extracellular space misinteract unlik occur produc deleteri effect transmembran protein contain intracellular domain fold function cytosol extracellular domain complet fold endoplasm reticulum function extracellular space thus hypothes extracellular domain transmembran protein exhibit weaker e r anticorrel intracellular domain analys human saccharomyc arabidopsi transmembran protein allow us confirm hypothesi result agreement model attribut e r anticorrel deleteri effect misfold andor misinteract | D004721;D008565 | T026;T116;T192;T123 |
34,665,247 | time durat light exposur conidia develop determin toler ultraviolet radiat metarhizium import genus soil inhabit fungi use biolog control insect effici biocontrol depend mainten inoculum viabil advers field condit solar ultraviolet uv radiat therefor increas toler metarhizium uv radiat necessari previous establish mycelium exposur visibl light increas toler uv radiat similar growth visibl light day induc product toler conidia howev studi evalu visibl light affect conidia relationship uv radiat never perform report relat short time exposur light around time conidi suffici induc product conidia increas photoreactiv capac uv toler metarhizium acridum conidia produc method retain characterist higher toler even mani day transfer dark furthermor show matur conidia acridum metarhizium brunneum still answer light regul uv toler suggest gene express possibl even dormant spore abl respond light dormant stage develop certain advantag confer improv environment persist metarhizium | D052981;D011836;D014466 | T004;T070;T032 |
34,665,246 | ensembl learn predict opioid relat overdos use statewid prescript drug monitor program hospit discharg data state tennesse develop valid algorithm predict day fatal nonfat opioid relat overdos use statewid data sourc includ prescript drug monitor program data hospit discharg data system data tennesse tn vital record current overdos prevent effort tn reli descript retrospect analys without prognost | D000701;D000073958 | T058;T131;T121;T109 |
34,665,240 | associ crowdsourc health care facil rate mortal us counti mortal across us counti vari consider death per peopl although patient satisfact health care associ patient facil level health outcom associ health care satisfact communiti level health outcom known | D017060 | T080 |
34,665,239 | incid cigarett smoke relaps among individu switch e cigarett tobacco product although e cigarett approv cessat devic mani smoke believ e cigarett help quit cigarett smoke success | D012008 | T046;T067 |
34,665,236 | cgasst signal function metabol kidney diseas cyclic gmpamp synthas cgas stimul interferon gene sting signal pathway sens presenc cytosol dna turn trigger downstream signal induc express inflammatori type interferon gene immun cell wherea innat immun function cgasst pathway well studi past year emerg evid suggest signal pathway may addit function beyond innat immun surveil consist notion dysregul cgasst signal pathway adipocyt hepatocyt renal proxim tubul epitheli cell associ metabol dysfunct impair energi homeostasi kidney diseas review summar current understand cgasst pathway sever metabol diseas obes insulin resist alcohol nonalcohol fatti liver diseas well acut kidney injuri chronic kidney diseas also review interact cgasst pathway lipid metabol last discuss potenti mechan cgasst signal regul metabol point toward futur avenu research target cgasst pathway possibl mean treat common metabol disord | D058186;D007370 | T116;T047;T121;T129;T037 |
34,665,235 | effect blue light filter versus clear intraocular implant color appear dozen studi investig whether blue light filter blf intraocular len iol implant influenc color vision general find studi test color vision per se rather measur color vision defici chromat discrimin use addit trichromat colorimetri assess color appear particip blf clear iol | D055253;D007910;D018918 | T040;T074;T061 |
34,665,234 | choroid vascular index differ cohort dri age relat macular degener purpos studi investig choroid lumin interstiti stromal alter use choroid vascular index cvi among differ cohort dri age relat macular degener damd compar healthi subject | D057092;D008268 | T047 |
34,665,233 | challeng associ ellipsoid zone intens measur use optic coher tomographi qualit evalu ellipsoid zone band optic coher tomographi valuabl clinic tool assess photoreceptor structur though quantit metric emerg awar challeng involv interpret quantit metric import clinic translat | D010786;D041623 | T025;T060 |
34,665,232 | demograph comorbid clinic variabl associ pointwis visual field damag glaucoma data agi cigt clinic trial investig differ across visual field vf rate glaucomat progress likelihood defect four diseas sever cross section comparison subgroup demograph comorbid clinic variabl | D005901;D014794 | T082;T047 |
34,665,231 | femtosecond laser assist small incis allogen endokeratophakia use hyperop lenticul rabbit investig morpholog histopatholog chang allogen endokeratophakia use hyperop lenticul deriv small incis lenticul extract smile | D048988;D018380;D006956 | T047;T061 |
34,665,228 | voluntarili stop eat drink conceptu person polici question although voluntarili stop eat drink vsed way hasten one death yet wide recogn practic unit state receiv increas attent medic bioethic literatur recent year brief review broader context human death die articl pose examin conceptu person public polici question vsed articl identifi essenti featur vsed discuss whether vsed type suicid identifi reason peopl may may choos vsed consid respons famili member profession caregiv peopl chosen vsed also consid public polici may permit regul restrict practic vsed examin question design increas understand vsed inform moral evalu practic | D001675 | T091 |
34,665,227 | copper transport ctr microtubul associ protein cgp import cryptococcus neoforman adapt nitrogen avail nitrogen limit previous shown import regul sever gene associ virul cryptococcus neoforman among high express gene low nitrogen condit ctr cgp encod copper transport microtubul associ protein respect howev function associ gene nitrogen limit nutrit stress experienc environ host remain determin moreov whether increas ctr cgp express link enhanc cryptococc drug toler previous observ low nitrogen condit yet elucid therefor present studi explor role cgp ctr c neoforman nitrogen stress adapt antifung suscept result show gene play role growth c neoforman nitrogen limit media nitrogen sourc assimil growth nitrogen poor woodi debri furthermor demonstr ctr cgp contribut oxid stress antifung suscept ctr mutant suscept fluconazol cgp mutant suscept fluconazol amphotericin b overal find improv understand role ctr cgp cryptococc drug toler adapt nitrogen avail | D000079922;D003455;D005656;D008869;D009584 | T004;T116;T196;T123 |
34,665,225 | program dna elimin silenc gene repetit sequenc somat cell multicellular organ genom cell general program dna elimin notabl except genom constanc rule dna elimin remov gene repetit element germlin genom form reduc somat genom various organ process dna elimin within organ high accur reproduc typic occur earli embryogenesi coincid germlin soma differenti dna elimin provid mechan silenc select gene repeat somat cell recent studi nematod suggest dna elimin remov chromosom end resolv sex chromosom fusion may also promot birth novel gene program dna elimin process divers among speci suggest dna elimin like evolv multipl time differ taxa grow list organ undergo dna elimin indic dna elimin may widespread previous appreci various organ serv complementari compar model studi function mechan evolut program dna elimin metazoan | D020868 | T045 |
34,665,224 | prognost valu comprehens intracoronari physiolog assess earli heart transplant evalu long term prognost valu invas assess coronari physiolog heart transplant larg multicentr registri | D023921;D053805;D016027 | T047;T061;T201 |
34,665,222 | monodopsi vischeria genom shed new light biolog eustigmatophyt alga member eustigmatophyt alga especi nannochloropsi microchloropsi tap biofuel product owe except high lipid content although extens genom transcriptom synthet biolog toolkit made avail nannochloropsi microchloropsi littl known eustigmatophyt present three near chromosom gapless genom assembl monodopsi strain c c mb vischeria strain c mb sister group nannochloropsi microchloropsi order eustigmatal genom contain unusu high percentag simpl repeat rang total assembl size unlik nannochloropsi microchloropsi long interspers nuclear element repeat abund monodopsi vischeria might constitut centromer region found mevalon nonmevalon pathway terpenoid biosynthesi present monodopsi vischeria differ nannochloropsi microchloropsi latter analysi reveal extens splice leader tran splice monodopsi vischeria gene altogeth high qualiti genom monodopsi vischeria serv much need outgroup advanc nannochloropsi microchloropsi research also shed new light biolog evolut eustigmatophyt alga | D058009 | T204 |
34,665,221 | identifi key regul intestin stem cell nich intestin tract line singl layer epithelium one fastest regener tissu bodi therefor requir activ exquisit control stem cell popul rapid renew epithelium necessari provid continu physic barrier intestin lumin microenviron contain abund microorgan whilst also ensur effici surfac absorpt dietari compon specialis epitheli cell popul import mainten intestin homeostasi deriv adult intestin stem cell isc activ cycl isc divid neutral drift mechan yield either isc transit amplifi epitheli cell latter differenti becom either absorpt lineag produc secretori factor contribut intestin barrier mainten signal cellular compart mechan control isc abund longev activ regul sever differ cell popul signal pathway intestin lamina propria togeth form isc nich howev complex isc nich communic mechan differ compon start unravel assist intestin organoidenteroidcolonoid singl cell imag sequenc technolog review explor interact well establish emerg isc nich compon impact intestin epithelium health context intestin injuri highlight futur direct implic rapid develop field | D055153 | T022 |
34,665,205 | associ tramadol vs codein prescript dispens mortal advers clinic outcom although tramadol increas use manag chronic noncanc pain safeti studi compar opioid | D002423 | T033 |
34,665,204 | effect combin vareniclin nicotin patch extend treatment durat smoke cessat random clinic trial smoke cessat medic routin use health care research suggest combin vareniclin nicotin patch extend durat vareniclin treatment may increas cessat effect | D061485 | T074;T121;T200;T109 |
34,665,203 | effect moder vs mild therapeut hypothermia mortal neurolog outcom comatos survivor hospit cardiac arrest capit chill random clinic trial comatos survivor hospit cardiac arrest experi high rate death sever neurolog injuri current guidelin recommend target temperatur manag c c hour howev small studi suggest potenti benefit target lower bodi temperatur | D001831 | T032 |
34,665,198 | interpret use clinic practic guidelin recommend user guid medic literatur clinician may reli recommend clinic practic guidelin manag patient | D019983;D017410 | T058;T170;T078;T064 |
34,665,192 | lipid oxid aldehyd format vitro gastrointestin digest roast scallop patinopecten yessoensi role ad antioxid bamboo leav studi investig lipid oxid aldehyd format roast scallop vitro gastrointestin digest effect co digest antioxid bamboo leav aob process result show content lipid hydroperoxid looh conjug dien cd schiff base sb increas gastrointestin digest besid malondialdehyd mda level total aldehyd format decreas initi gastric stage increas intestin stage result hplc esi msms analysi show content hexan hex tran tran octadien ode tran tran decadien dde hydroxyhexen hhe hydroxynonen hne digest juic initi decreas increas gastrointestin digest meanwhil content acrolein propan tran penten end intestin digest lower initi stage gastric digest addit digest roast scallop caus signific oxid polyunsatur fatti acid pufa releas free fatti acid ffa intestin phase posit relat aldehyd product howev co digest aob signific reduc lipid oxid format lipid oxid product looh cd sb aldehyd gastrointestin digest indic addit aob effect reduc gastrointestin lipid oxid | D000447;D000975;D015227;D049897 | T044;T121;T109;T123;T039;T204 |
34,665,186 | non invas diagnosi crohn diseas base ser combin pca svm crohn diseas cd idiopath chronic inflammatori bowel diseas without cure cd patient first diagnos invas endoscopi clinic patholog examin requir confirm diagnosi henc develop non invas rapid accur diagnosi method cd patient essenti studi urin sampl cd patient includ activ cd acd patient inact cd icd patient healthi control hc investig surfac enhanc raman spectroscopi ser statist analysi three group ie cdhc acdhc icdhc perform measur data princip compon analysi pca support vector machin svm pca linear discrimin analysi lda employ establish classif model distinguish patient hc averag ser spectra patient hc raman peak belong lipid protein nucleic acid stronger patient hc show classif accuraci cdhc base pca svm higher pca lda vs classif accuraci acdhc base pca svm higher icdhc vs classif model establish distinguish acd hc sensit specif indic metabol chang patient could identifi measur urin ser acd hc could distinguish effect find help clinician diagnos cd patient monitor progress recurr diseas | D003424;D060388 | T047;T066;T081 |
34,665,185 | magnet radio label bio hybrid scaffold promot track vivo progress bone regener work describ prepar character function magnet nanoparticl bone tissu mimet scaffold compos collagen hydroxyapatit obtain biominer process bone remodel take place sever week possibl follow vivo quick reliabl way still outstand issu therefor work aim produc implant materi follow vivo bone regener use exist non invas imag techniqu mri aim suitabl design biocompat spion link hybrid scaffold use two differ strategi one involv nake spion nmnps use coat activ spion mnps expos carboxyl acid function allow coval attach mnps collagen molecul physico chemic character carri investig morpholog crystallin stabil function materi follow mri analys evalu radiotrac uptak tc tc mdp cell prolifer assay vitro carri check cytotox demonstr side effect due spion achiev result demonstr nake coat spion homogen distribut scaffold incorpor synthesi process work demonstr suitabl approach develop biomateri bone regener allow monitor heal progress even long term follow studi | D001861;D054457 | T042;T122 |
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