PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,665,018 | effect avail treatment game disord children adolesc systemat review preval game disord gd compar preval obsess compuls disord thus demonstr necess address internet game disord igd gd general gd introduc psychiatr disord intern classif diseas pave way treatment prevent intervent review research avail treatment intervent children adolesc initi search result studi end exclud inappropri studi accord six inclus criteria studi confirm cognit behavior therapi cbt cbt base intervent use case comorbid depress attent deficithyperact disord appropri pharmaceut intervent also effect option intervent combin cbt famili therapi cbt base therapi took place special camp famili support expedi even treatment expedi seem play major role remark littl knowledg exist regard treatment intervent children age year old therefor studi need carri age rang especi compar efficaci intervent | D001289;D015928;D009771;D018910 | T048;T073;T061 |
34,665,017 | methicillin resist staphylococcus aureus municip abattoir nigeria show high similar clone possibl transmiss slaughter anim human recent year methicillin resist staphylococcus aureus mrsa gain interest veterinari medicin due zoonot potenti current littl inform avail genotyp virul characterist mrsa isol detect nigerian abattoir better understand epidemiolog mrsa associ abattoir food chain environ nigeria total isol human n slaughter anim n environ n previous spa type recov character staphylococcus cassett chromosom mec scc mec type phenotyp genotyp antimicrobi suscept test addit mrsa strain new spa type subject multilocus sequenc type similar strain analyz base result dna microarray analysi mrsa strain harbor two distinct scc mec type iva v belong four clonal cluster cc cc cc cc mrsa new spa type n harbor scc mec type iva seven mrsa strain belong st three strain assign st mrsa isol categor six virul profil detect rate panton valentin leukocidin gene high antimicrobi suscept profil mrsa vari wide strain phenotyp resist correspond relev resist gene harbor detect high similar mrsa strain slaughter anim abattoir worker environ underlin need use adequ measur nigerian abattoir prevent spread transmiss mrsa human food | D055624;D013203 | T007;T047 |
34,665,008 | effect binocular virtual realiti train repair visual field defect glaucoma visual field defect caus glaucoma serious affect qualiti life patient clinic type visual field defect consid irrevers aim studi use binocular virtual realiti train vr train repair visual field defect glaucoma patient improv qualiti life patient provid new therapeut strategi rehabilit glaucoma seventi glaucoma patient median rang year recruit divid control train group fifti four patient data analyz train group n receiv binocular vr train month control group n maintain convent treatment without intervent visual field index vfi mean defect md retin nerv fiber layer averag thick rnfl ganglion cell layer averag thick gcl averag thick train followup analyz train group vfi valu z p md valu z p signific improv month train month train vfi valu z p md valu z p signific improv signific differ chang averag thick rnfl p gcl averag p month train wherea control group except reduct gcl averag thick z p compar baselin data followup data statist signific compar baselin data data suggest binocular vr train signific improv visual field defect glaucoma patient warrant studi larg sampl size clinic trail registr number chictr | D005901;D000076142 | T047;T066 |
34,665,000 | key popul accept experi communiti base peer navig intervent support engag hiv care tijuana mexico engag hiv care continuum among peopl live hiv essenti prevent ongo transmiss although evid need comprehens approach eg peer navig improv hiv care continuum limit knowledg peer navig model might work improv hiv care continuum low resourc set among latinx key popul eg person inject drug femal sex worker men sex men transgend women therefor articl aim qualit assess member key popul accept conexion salud healthi connect communiti base peer navig intervent implement tijuana mexico analysi draw upon postintervent survey data particip data qualit interview particip particip found intervent accept discuss way peer navig influenti educ particip hiv antiretrovir therapi art link particip exist hiv care ancillari servic tijuana provid emot instrument support facilit engag hiv treatment art adher intervent emphas use peer navig deep understand sociostructur barrier eg substanc use homeless hiv posit key popul face tijuana find studi may inform program high vulner popul similar set | D055030;D015658;D060386;D000072339;D015819 | T047;T101;T098;T097;T048;T033 |
34,664,999 | unconvent radiotherapi enhanc immunotherapi efficaci bulki tumor case report determin appropri manag strategi patient larg tumor mass challeng issu unconvent radiotherapi modal spatial fraction radiat therapi sfrt associ dramat respons recent studi suggest system immun activ may trigger sfrt deliveri primari tumor lesion report describ case patient treat novel form immun spare partial ablat irradi ispart bulki periton metastasi renal cell cancer refractori anti pd therapi nivolumab third line therapi sequenti therapi sunitinib cabozantinib observ respons suggest may synergist effect ispart immunotherapi case report support inclus ispart patient present bulki lesion treat checkpoint inhibitor | D002292;D019583;D007167;D007680;D010534 | T191;T061 |
34,664,993 | comprehens methyl profil csf cfdna reveal pathogenesi diagnost marker earli onset parkinson diseas background earli onset parkinson diseas eopd one uncommon parkinson diseas subtyp characterist clinicopatholog featur full epigenom profil eopd larg unknown method perform first studi investig eopd full methyl profil cerebrospin fluid csf cell free dna cfdna eopd patient control patient result differenti methyl gene identifi eopd hypermethyl far outweigh hypomethyl gene number cluster enrich analys identifi aberr neuron function immun respons weight correl network analysi demonstr signific correl methyl signatur clock draw test cdt mini mental state examin mmse educ work status alcohol drink histori hamilton anxieti scale hama sever key network gene eopd aberr methyl also identifi conclus methyl profil signatur csf cfdna reveal first time eopd aberr methyl signatur correl educ work status alcohol drink histori cdt mmse hama | D019175 | T044 |
34,664,991 | import cellular immun respons hiv implic antibodi product vaccin design despit mani year discoveri human immunodefici virus hiv prophylact vaccin hiv still need failur vaccin clinic trial field differ caus main due difficulti identifi correct antigen abl prime optim b cell lineag make seri somat mutat necessari generat broad neutral antibodi bnab b cell respons bnab product howev function strong influenc presenc popul cd lymphocyt main present lymphoid organ follicular helper cell tfh review import contribut tfh cell hiv respons highlight futur therapi perspect base observ describ advanc technolog avail nowaday wide knowledg built past year hiv may eventu creat best scenario generat effect vaccin | D000917;D015497 | T038;T005 |
34,664,990 | biosignatur associ organ matter late paleoproterozo stromatolit dolomit implic martian carbon document biosignatur precambrian rock import requir search evid life ancient planetari surfac three major kind biosignatur crucial import primari microbi sedimentari textur diagenet organominer assemblag stabl isotop composit studi present new petrograph mineralog organ geochem analys biosignatur dolomit stromatolit pethei group nwt canada kasegalik format belcher group nunavut canada approxim contemporari late paleoproterozo stromatolit bear dolomit unit deposit great oxid event micro raman optic microscopi use identifi character possibl diagenet biosignatur includ close spatial associ diagenet materi ferric ferrous oxid anatas dissemin organ matter om dolomit groundmass textur miner ball mani petrograph relationship point oxid om either biotic abiot associ iron reduct chemic oscil reaction oxid om stromatolit consist widespread oxid biomass late paleoproterozo shunga francevillian event biosignatur identifi studi also compar possibl carbon outcrop mar therebi contribut basi comparison potenti biosignatur ancient martian terrain similar drawn paleoenviron studi unit isidi chryse planitia locat potenti extraterrestri dolomit stromatolit | D005118;D018535 | T070;T083 |
34,664,988 | effect cannabi base medicin treatment cachexia systemat review meta analysi background cachexia preval condit associ under chronic diseas wast skelet muscl adipos tissu loss cachect patient associ higher rate disabl reduc qualiti life qol wors prognosi larg unmet need develop strategi treat cachexia current standard guidelin manag cachexia activ endogen cannabinoid receptor exogen cannabinoid demonstr potenti increas appetit reduc catabol shown anti inflammatori properti sinc singl pharmacolog agent current recommend use cachexia potenti cannabinoid appetit stimul warrant research assess current evid object review aim evalu evid efficaci cannabi base medicin product placebo activ treatment anorexia cachexia syndrom improv appetit weight qol method literatur search medlin embas central web scienc core collect articl publish februari conduct random control trial compar use cannabi base medicin versus placeboact treatment patient cachexia screen qualiti evid includ studi assess use grade framework risk bias judg use cochran risk bias tool result total five studi encompass particip found elig pool group effect size chang appetit confid interv favor control group p addit signific differ weight chang chang qol cannabinoid versus placebooth treatment observ qualiti evid five studi assess low conclus lack high qualiti evid recommend use cannabinoid treatment cachexia given limit avail pharmacolog option cachexia potenti cannabinoid increas appetit alter immun system research need clinic recommend pharmacolog manag cachexia made | D002186;D002188 | T167;T121;T002;T109 |
34,664,987 | matern sar cov infect elicit sexual dimorph placent immun respons persist bias toward higher preval increas sever coronavirus diseas covid male under mechan account sex differ remain incomplet understood interferon respons implic modul covid diseas adult play key role placent antivir respons moreov interferon respons shown alter fc receptor express therefor may affect placent antibodi transfer examin intersect matern fetal antibodi transfer viral induc placent interferon respons fetal sex pregnant women infect sever acut respiratori syndrom coronavirus sar cov placent fc receptor abund interferon stimul gene isg express sar cov antibodi transfer interrog human pregnanc sexual dimorph express placent fc receptor isg protein interleukin observ matern sar cov infect regul featur placent tissu pregnant individu male fetus reduc matern sar cov specif antibodi titer impair placent antibodi transfer also observ pregnanc male fetus result demonstr fetal sex specif matern placent adapt innat immun respons sar cov | D000086382;D011251 | T047;T067 |
34,664,986 | cell cell communic plant pathogen interact sessil plant continu challeng chang surround environ must surviv defend multitud pathogen plant evolv mode pathogen recognit activ signal cascad reactiv oxygen speci mitogen activ protein kinas ca pathway coordin hormon signal execut defens respons local system level phytopathogen evolv manipul cellular hormon signal exploit host cell cell connect mani way multipl level overal triumph pathogen depend effici pathogen recogn rapid plant respons initi effici intercellular communic via apoplast symplast rout review intercellular communic plant mediat manipul maneuv plant pathogen interact formula see text author dedic work public domain creativ common cc right reserv licens waiv right work worldwid copyright law includ relat neighbor right extent allow law | D002450;D010944 | T043;T002 |
34,664,980 | character pathogen diplodia lasiodiplodia neofusicoccum speci caus botryosphaeria canker dieback appl tree central chile recent year number appl tree affect botryosphaeria canker dieback consider increas central chile studi aim identifi speci botryosphaeriacea associ canker dieback symptom estim diseas incid distribut studi pathogen virul appl fruit crop field survey commerci orchard appl year old conduct local obtain symptomat branch trunk sampl grow season incid botryosphaeria canker dieback rang total isol botryosphaeriacea spp obtain canker morpholog identif along phylogenet studi intern transcrib spacer region rdna part translat elong factor tef part tubulin tub gene allow us identifi diplodia mutila n isol seriata n isol lasiodiplodia theobroma n isol neofusicoccum arbuti n isol l theobroma isol main appl dieback northern local pathogen test pathogen caus canker dieback symptom lignifi twig appl pear walnut green grapevin shoot field isol n arbuti virul reproduc sever canker lignifi tissu inocul studi report first time mutila l theobroma associ botryosphaeria canker dieback chile first descript n arbuti caus appl dieback worldwid | D001203;D027845 | T004;T002;T168 |
34,664,978 | pregnanc influenc immun respons sar cov pregnanc fetal sex influenc qualiti antibodi respons sar cov infect immun atyeo et al bordt et al | D000086382;D000086402 | T047;T005;T067 |
34,664,977 | risk epidem develop nurseri soil inoculum phytophthora ramorum soilborn inoculum aris buri infest leaf debri may contribut persist phytophthora ramorum recurr posit nurseri initi new epidem inoculum must surviv also produc sporangia time conduc infect soil surfac assess risk perform two year long experi soil plot nation ornament research site dominican univers california inocul rhododendron leaf disk buri depth cm earli summer inoculum bait soil surfac noninfest leaf disk retriev assess pathogen viabil sporul capac everi week two week long trial conduct abl consist cultur p ramorum time period soil incub rapid reduc capac inoculum sporul especi cm howev sporul capac increas onset season cooler temperatur p ramorum bait frequent novemb januari especi inoculum buri cm day bait period januari also bait p ramorum inoculum buri cm previous june valid prior observ p ramorum pose greater risk exposur cooler temperatur provid evid infest leaf debri play role perpetu p ramorum nurseri work provid novel insight surviv epidem behavior p ramorum nurseri soil | D010838;D010935 | T204;T047 |
34,664,976 | character aggress take root rot pathogen isol symptomat bermudagrass put green take root rot diseas ultradwarf bermudagrass put green caus gaeumannomyc gramini gg gaeumannomyc sp gx gaeumannomyc graminicola ggram candidacolonium cynodonti cc magnaporthiopsi cynodonti mc mani etiolog epidemiolog compon diseas remain unknown improv pathogen identif understand aggress pathogen along growth differ temperatur advanc knowledg diseas develop optim manag strategi take root rot pathogen isol symptomat bermudagrass root stolon piec differ golf cours isol gg gx ggram cc mc use inocul champion bermudagrass planta aggress assay pathogen also evalu c determin growth temperatur optima infect plant tissu use develop real time pcr high resolut melt assay pathogen detect assay abl differenti pathogen direct infect plant tissu use singl primer pair general ggram gg gx aggress cc mc exhibit moder aggress pathogen aggress incub c compar c grew optim c pathogen exhibit limit growth c growth c data provid import inform diseas causal agent may improv take root rot manag | D001203;D031744;D010935 | T004;T047;T002 |
34,664,975 | autophagi gene chatg chatg requir reproduct develop virul septin assembl cochliobolus heterostrophus autophagi high conserv degrad process crucial cell growth develop eukaryot especi face starvat stress condit evalu function atg atg myceli growth asexu sexual develop virul cochliobolus heterostrophus chatg chatg mutant generat gene replac strain delet chatg chatg gene show signific chang veget growth develop conidia ascospor compar wild type strain autophagi process block virul reduc dramat chatg chatg mutant addit delet chatg chatg disord cdc subcellular local format septin ring direct physic interact chatg chatg detect yeast two hybrid assay chatg gfp dispers throughout cytoplasm although gfp chatg appear punctat structur phenotyp restor complement strain taken togeth find indic chatg chatg crucial autophagi regul fungal growth develop virul local septin c heterostrophus | D001203;D058112 | T004;T116;T126 |
34,664,974 | divers botryosphaeriacea diaporth speci associ postharvest appl fruit decay serbia famili botryosphaeriacea genus diaporth famili diaporthacea repres divers group plant pathogen includ causal agent leaf spot shoot blight branch stem canker dieback pre postharvest appl fruit decay appl fruit symptom light dark brown decay collect harvest thirti select isol pathogen confirm identifi character base multilocus phylogeni morpholog five speci famili botryosphaeriacea two genus diaporth fam diaporthacea discov common isol diplodia seriata follow botryosphaeria dothidea work diaporth rudi describ new postharvest pathogen appl fruit diplodia bulgarica diplodia sapinea neofusicoccum yunnanens diaporth ere initi describ postharvest appl sapinea postharvest quinc medlar fruit pathogen serbia speci famili botryosphaeriacea genus diaporth known caus diseas host endophyt natur wide host rang find studi impli may becom new challeng success fruit product | D027845 | T002;T168 |
34,664,973 | genom resourc ex type phytophthora citricola well authent isol p hibernali p nicotiana p syringa phytophthora one import genera plant pathogen mani member caus high econom loss worldwid build robust molecular identif system import inform well authent specimen prefer ex type specimen refer genom well authent specimen form critic foundat genet biolog research diagnost applic studi describ four draft phytophthora genom resourc ex type phytophthora citricola bl p wpc contig mb well authent specimen p syringa blg p wpc contig mb p hibernali blg p wpc contig mb p nicotiana bl p wpc contig mb generat minion long read high throughput sequenc technolog oxford nanopor technolog use qualiti read assembl high coverag genom p citricola coverag annot gene p nicotiana coverag annot gene p syringa coverag annot gene p hibernali coverag annot gene avail genom sequenc annot predict draft genom accommod various basic appli research includ diagnost protect global agricultur | D010838 | T204 |
34,664,972 | covid mrna vaccin drive differenti antibodi fc function profil pregnant lactat nonpregn women substanti immunolog chang occur throughout pregnanc render mother immunolog toler fetus allow fetal growth howev addit local system immunolog adapt also occur allow matern immun system continu protect dyad pathogen pregnanc birth lactat fine balanc toler immun along physiolog hormon chang contribut increas suscept particular infect pregnanc includ sever coronavirus diseas covid whether chang also make pregnant women less respons vaccin induc alter immun respons vaccin remain incomplet understood defin potenti chang vaccin respons pregnanc lactat undertook deep sequenc humor vaccin respons group pregnant lactat women nonpregn age match control vaccin specif titer compar pregnant women lactat women nonpregn control howev fc receptor fcr bind antibodi effector function induc delay kinet pregnant lactat women compar nonpregn women first vaccin dose normal second dose vaccin boost result high fcr bind titer breastmilk data suggest pregnanc promot resist generat proinflammatori antibodi indic critic need follow prime boost timelin vulner popul ensur full immun attain | D000086382;D000086663 | T047;T200;T067 |
34,664,967 | structur insight human mitochondri pyruv carrier complex pyruv metabol requir mitochondri pyruv carrier mpc protein transport pyruv intermembran space inner mitochondri membran mitochondri matrix lack atom structur mpc hamper understand function state mpc molecular interact substrat inhibitor develop de novo model human mpc complex character conform dynam mpc heterodim form mpc mpc mpc comput simul result reveal function mpc prefer adopt inward open conform carrier open matrix side wherea outward open state less popul energi barrier pyruv transport mpc low enough inhibitor uk block pyruv transport stabli bind mpc notabl consist experiment result mpc lh mutat signific alter conform mpc thus fail substrat transport howev mpc rw mutat seem retain transport activ present de novo model mpc complex provid structur insight conform state mpc complex mechanist understand interact substrateinhibitor mpc protein | D027501 | T116;T123 |
34,664,964 | forecast avalanch branch actomyosin network network scienc machin learn explor dynam structur effect actin relat protein arp actomyosin network use mechanochem simul activ matter network nanoscal arp complex alter topolog actomyosin nucleat daughter filament angl respect mother filament subcellular scale orchestr format branch actomyosin network use coars grain approach sought understand actomyosin network tempor spatial reorgan vari concentr arp complex driven motor dynam network stall high concentr arp contract low arp concentr intermedi arp concentr howev actomyosin network form loos connect cluster may collaps sudden driven motor physic phenomenon call avalanch larg due margin instabl inher morpholog branch actomyosin network arp complex present embrac data scienc approach unveil higher order pattern branch actomyosin network discov sudden chang social network topolog actomyosin new type avalanch addit two type avalanch associ sudden chang size shape whole actomyosin network shown previous investig new find promot import use network theori machin learn model forecast avalanch actomyosin network mechan arp complex shape architectur branch actomyosin network obtain paper help us better understand emerg reorgan topolog dens actomyosin network difficult detect experi | D000205;D056004 | T044;T116;T066;T123 |
34,664,962 | chemic compon fruit morus nigra linn methyl caffeat potenti anticanc agent target phosphoglycer dehydrogenas two previous undescrib compound moranigrin morusamin along known compound isol fruit morus nigra linn structur character use spectroscop data electron circular dichroism analys isol evalu inhibitori effect phosphoglycer dehydrogenas phgdh enzym catalyz first commit step synthesi glucos deriv serin associ mani kind cancer among compound methyl caffeat exhibit effect inhibit phgdh direct bound phgdh base microscal thermophoresi method cellular thermal shift assay biochem assay reveal noncompetit inhibitor respect substrat phosphoglycer exhibit concentr depend inhibit molecular dock demonstr coordin alloster site phgdh low bind energi meanwhil select toxic high phgdh express cancer cell line could caus apoptosi cervic cancer cell micromolar concentr could obvious inhibit tumor growth hela xenograft mous model low toxic therefor could develop potenti inhibitor phgdh treatment cancer present studi provid inform nigra function food pharmaceut supplement applic cancer prevent treatment | D000970;D031625 | T121;T002;T109 |
34,664,961 | diethylpyrocarbon footprint membran protein micell membran protein play crucial role cell signal transport thus target mani small molecul drug character membran protein structur pose challeng high resolut biophys tool transmembran tm domain hydrophob open opportun mass spectrometri ms base footprint hydrophob reagent diethylpyrocarbon depc heavili studi footprint water solubl protein label surfac residu via straightforward protocol streamlin ms base footprint workflow test applic membran protein footprint vitamin k epoxid reductas vkor membran protein depc result demonstr besid label hydrophil extracellular extramembran em domain depc also diffus hydrophob tm domain subsequ label region label process facilit tip sonic enhanc reagent diffus micell analyz correl residu modif extent theoret access surfac area percentag asa data general show good correl residu locat compar convent hydrophil footprint relat hydrophob depc map membran protein tm domain suggest reagent hydrophob exploit obtain structur inform membran span region encourag result assist develop effici footprint membran protein tm domain footprint enabl understand relationship reagent hydrophob prefer label site | D008565 | T192;T116;T123 |
34,664,960 | discoveri ihmt ezh potent select enhanc zest homolog ezh inhibitor treatment b cell lymphoma enhanc zest homologu ezh catalyt subunit polycomb repress complex catalyz methyl histon h lysin hk overexpress mutat ezh identifi hematolog malign solid tumor base structur epz bind model prc design seri analogu aim improv activ ezh mutant structur activ relationship sar explor enzymat cellular level led discoveri inhibitor biochem assay inhibit ezh ic nm high select histon methyltransferas also potent ezh mutant ezh yf ic nm furthermor show appar inhibitori activ human ether go go relat gene herg ic vivo exhibit favor pharmacokinet properti oral administr show better efficaci pfeiffer karpa cell mediat xenograft mous model indic might new potenti therapeut candid ezh mutant cancer | D055808 | T062 |
34,664,957 | amphiphil intric layer grapheneg c n nanosheet hybrid heterostructur tri triazin form graphit carbon nitrid g c n stabl two dimension materi result intric layer format graphen materi g c n amphiphil materi stabil picker emuls emulsifi effect dispers graphen due various technolog applic hybrid nanosheet aqueous environ essenti studi interact water molecul graphen g c n grg c n combin heterostructur although studi perform signifi water orient interfaci layer find lack detail studi use various dynam structur properti interfaci water molecul interfac grg c n hybrid structur one rare found amphiphil interfac g c n side appropri explor water affin due avail heterogen interfaci aqueous interact adopt classic molecular dynam simul use two model water molecul studi structur dynam aqueous interfac correl structur properti dynam spectral properti understand overal behavior amphiphil interfac result branch two signific hydrogen bond hb properti hb count hb strength among water molecul differ layer hb count differ layer water correl use averag distanc distribut p ro tetrahedr order paramet hb donoracceptor count total hbs per water molecul conspicu differ found hb count relat dynam system hb lifetim diffus coeffici hint equival strength hbs differ layer find conclud amphiphil grg c n interfac help understand various interfaci physic chemic process | D006108 | T196;T109 |
34,664,954 | engin microspher load non mulberri silk base bioprint vascular cardiac patch oxygen releas immunomodulatori potenti hostil myocardi microenviron post ischem injuri myocardi infarct play decis role determin fate tissu engin approach therefor engin hybrid print platform modul mi microenviron improv implant accept surfac critic requir reconstruct infarct heart employ non mulberri silk base conduct bioink compris carbon nanotub cnts bioprint function vascular anisotrop cardiac construct immunofluoresc stain polymeras chain reaction base gene express studi electrophysiolog studi show inclus cnts bioink play signific role upregul matur cardiac biomark sarcomer format beat rate promot cardiomyocyt viabil construct microinject calcium peroxid il load gelatin methacryloyl microspher measur oxygen concentr reveal microspher upheld oxygen avail maintain cellular viabil least day hypox environ also abil microinject il microspher modul macrophag anti inflammatori phenotyp vitro uncov use immunofluoresc stain gene express studi furthermor vivo subcutan implant microspher inject construct provid insight toward extend time frame achiev deal hostil microenviron promot host neovascular implant accept | D062028;D023822 | T063;T061 |
34,664,951 | versatil type inorganicorgan nir iiaiib fluorophor strateg design toward molecular imag theranost vivo imag second near infrar window nir ii nm enabl us look deepli live subject produc marvel opportun biomed research clinic applic recent upsurg interdisciplinari studi focus develop versatil type inorganicorgan fluorophor use noninvas nir iiaiib imag nir iia nm nir iib nm near zero tissu autofluoresc deeper tissu penetr review provid overview report publish date design properti molecular imag theranost inorganicorgan nir iiaiib fluorophor first summar design concept date function nir iiaiib biomateri order singl wall carbon nanotub swcnts quantum dot qds rare earth dope nanoparticl renp organ fluorophor of novel imag modal versatil biomed applic brought superior fluoresc properti review final challeng perspect futur clinic translat aim boost clinic applic progress nir iia nir iib imag technolog highlight | D037742;D057285 | T091;T061;T104;T073 |
34,664,948 | benchmark test guidelin deerpeldor experi nitroxid label biomolecul distanc distribut inform obtain puls dipolar epr spectroscopi provid import contribut mani studi structur biolog increas inform use integr structur model deliv uniqu restraint width conform ensembl order ensur reliabl structur model biolog conclus herein defin qualiti standard sampl prepar character measur distribut dipol dipol coupl paramagnet label convers primari time domain data distanc distribut interpret distribut report result guidelin substanti multi laboratori benchmark studi analysi data set known distanc distribut ground truth studi guidelin focus protein label nitroxid doubl electron electron reson deer aka peldor measur provid suggest proceed analog case | D013113 | T130 |
34,664,947 | situ prevascular strategi three dimension porous conduit neural tissu engin neovascular crucial peripher nerv regener long term function restor previous studi emphas strategi enhanc axon repair vascular describ develop applic situ prevascular strategi use porous nerv guidanc conduit ngcs achiev angiogenesi mediat neural regener optim poros ngc critic featur achiev neovascular nerv growth patenc hollow silk fibroinpoli l lactic acid co caprolacton ngcs spong like wall fabric use electrospin freez dri vitro result show porous ngc favor cell biocompat neuroregener potenti import angiogen activ result mechanist studi suggest activ hif signal might associ process also test situ prevascular porous ngcs vivo transplant mm rat sciatic nerv defect model aim regener sever nerv prevascular porous ngcs great enhanc intraneur angiogenesi result demonstr neurogenesi eight week transplant perform prevascular ngcs similar tradit autograft term improv anatom structur morpholog neural function conclus combin reason fabric pore conduit structur situ prevascular promot function nerv regener suggest altern strategi achiev function recoveri peripher nerv trauma | D023822 | T061 |
34,664,946 | asymmetr silica nanoparticl tailor spiki coverag deriv silica polym cooper assembl enhanc hemocompat gene deliveri asymmetr mesopor silica nanoparticl amsn one side featur spiki nanotopographi side smooth solid synthes via ethylenediamin eda direct silica polym cooper assembl approach simpli vari eda amount x amsn x sampl adjust spiki surfac coverag obtain demonstr spiki coverag higher improv hemocompat amsn x possibl due reduc contact area smooth side expos red blood cell rbc membran moreov amsn amsn high spiki coverag enhanc plasmid dna pdna load bind capabl well cellular uptak hek cell thus result high transfect perform good hemocompat high perform pdna deliveri amsn x high spiki coverag allow serv promis nonvir vector potenti applic gene therapi dna vaccin | D018014 | T062;T063 |
34,664,944 | incorpor function rubisco activas engin carboxysom enhanc carbon fixat carboxysom versatil paradigm prokaryot organell proteinac self assembl microcompart play essenti role carbon fixat cyanobacteria chemoautotroph carboxysom encapsul central co fix enzym ribulos bisphosph carboxylaseoxygenas rubisco use polyhedr protein shell select permeabl specif metabolit favor rubisco carboxyl tremend interest repurpos carboxysom boost carbon fixat heterolog organ develop design engin carboxysom coexpress rubisco activas compon cbbq cbbo carboxysom escherichia coli result show cbbq cbbo could assembl reconstitut carboxysom intrins compon incorpor cbbq cbbo within carboxysom promot activ rubisco enhanc co fixat activ recombin carboxysom also show structur composit carboxysom could modifi differ express system repres plastic carboxysom architectur translat term studi inform strategi engin modul carboxysom divers biotechnolog applic | D012273;D010959 | T116;T121;T126 |
34,664,943 | rapid enrich detect silk residu tomb doubl antibodi sandwich elisa base immunomagnet bead extract identif silk residu tomb great signific studi distribut spread earli silk howev complex organ matter tomb hinder accur identif silk studi doubl antibodi sandwich enzym link immunosorb assay elisa base immunomagnet bead imb develop rapid enrich detect silk residu doubl antibodi sandwich elisa method establish pair imb prepar silk fibroin monoclon antibodi sf silk fibroin monoclon label antibodi bio sf highest detect sensit linear detect rang ng ml detect limit ng ml method excel extract analysi silk residu archaeolog imprint soil sampl success identifi silk residu sampl final stage silk degrad physic invis silk proteom analysi result demonstr feasibl practic method | D005349;D047011 | T116;T121;T123 |
34,664,941 | effici erad bacteri biofilm high specif graphen base nanocomposit sheet bacteri biofilm usual resist antibiot thus power method requir remov nanomateri involv combin treatment modal recent recogn effect altern combat biofilm howev target control releas bacteri infect still major challeng present intellig phototherapeut nanoplatform consist aptam apt indocyanin green icg carboxyl function graphen oxid go cooh name icg go apt target treatment biofilm form salmonella typhimurium sinc apt conjug nanosheet nss specif accumul near abscess caus pathogen enhanc great local drug molecul concentr promot precis deliveri simultan generat heat reactiv oxygen speci near infrar irradi photothermalphotodynam therapi therebi signific enhanc biofilm elimin phototherapeut icg go apt also display good biocompat import multifunct phototherapeut platform show effici biofilm elimin effici greater abscess format model therefor icg go apt nss bacteria target capabl provid reliabl tool clinic bacteri infect circumv antibiot resist | D006108;D053761 | T073;T196;T109 |
34,664,935 | unveil sodium ion pollut spray dri precursor implic green upcycl spent lithium ion batteri unclear impur pollut one key scientif problem limit larg scale product new lithium ion batteri lib spent lib work first report pollut path pollut degre solut method sodium ion recycl process spent lib real world result show sodium ion intrud precursor particl form crystallin salt anion leach acid cover transit metal element therebi result fail precursor specif intrus sodium ion produc varieti pollut contain metal oxid bond na nao na precursor surfac activ lattic oxygen adsorb react form organ oxygen chemic oxygen free oxygen high deterior surfac cleanli strict control consumpt sodium salt step use ammonia instead naoh ph regul effect solv sodium ion pollut prepar high qualiti batteri precursor reveal green upcycl spent lib strengthen design recycl process reduc consumpt chemic reagent produc unexpect secondari pollut | D059029;D008094 | T196;T121;T068 |
34,664,934 | novel nanocarri platform effect treatment viscer leishmaniasi leishmaniasi among five parasit diseas still requir develop new drug ultrasmal cerium ce cation dope maghemit fe nanoparticl nps test potenti drug treat viscer leishmaniasi diseas affect million peopl worldwid nps engin bind polycation branch polyethylenimin pei polym therebi ruptur singl lysosom parasit enabl entri anti leishmania drug pentamidin exploit known lanthanid cationcomplex base coordin chemic reactiv enabl bind activ agent onto surfac nps optim fabric cytotox nps optim via doe design experi process use identifi optim np toxic two stage parasit promastigot propag insect amastigot infect mammalian host screen identifi singl optim np doe opt examin mous model viscer leishmaniasi intraven inject nps advers effect cellular composit biochem paramet blood demonstr sign system toxic optim np abl erad viscer diseas caus leishmania donovani infect studi demonstr versatil abil cerium dope nps bind least two cytotox ligand approach could use optim bind differ drug treatment diseas includ cancer sinc resist treatment nanocarri report date approach could potenti overcom drug resist emerg use solubl small molecul drug | D007898 | T047 |
34,664,926 | photoelectrochem il immunoassay manufactur multifunct catechol modifi tio scaffold increas interest use photoelectrochemistri enhanc signal nois ratio sensit electrochem biosensor nevertheless remain challeng creat photoelectrochem biosensor found stabl materi system also easili biofunction sens applic herein photoelectrochem immunosensor report concentr target protein direct correl chang measur photocurr materi system photoelectrod signal transduc involv use catechol ligand modifi properti tio nanostructur three prong approach morpholog tune photoabsorpt enhanc facilit bioconjug catechol modifi tio photoelectrod combin signal direct immunoassay detect interleukin il key biomark diagnos monitor various diseas catechol ligand ad hydrotherm synthesi tio enabl growth three dimension nanostructur form high porous photoelectrod provid three dimension scaffold immobil captur antibodi surfac modif catechol ligand great enhanc photocurr generat tio photoelectrod improv photoabsorpt visibl rang addit catechol molecul facilit bioconjug probe immobil form schiff base coh group nh group captur antibodi highest photocurr achiev herein cm repres enhanc factor unmodifi tio fabric immunosensor show limit detect pg ml log linear dynam rang pg ml il human blood plasma | D015374;D055664;D007118 | T059;T075 |
34,664,925 | eros tooth wear among athlet follow articl deal various consider concern frequent observ occurr dental eros athlet summar basic eros tooth wear develop well special etiolog factor group athlet increas preval dental eros conclud prevent advic origin publish german quintessenz zahnm | D019217;D014077;D057085 | T047;T037;T020 |
34,664,923 | new speci pseudostrandesia savatenalinton marten ostracoda crustacea collect two pet shop central japan alien speci undescrib speci freshwat ostracod belong genus pseudostrandesia savatenalinton marten collect two pet shop kanto region central japan speci herein name pseudostrandesia tenebrarum sp nov similar four speci previous report southeast asia distinguish carapac appendag featur second speci genus male known nine previous describ speci genus one exclus known turkey other found southeast asia vicin one also record india east china two scenario explain exist pseudostrandesia tenebrarum sp nov pet shop japan either nativ japan yet discov natur habitat alien speci perhap unwit import plant fish pet trade review likelihood scenario conclud although insuffici evid sure potenti alien speci japan like origin southeast asia evidenc close morpholog resembl particular southeast asian speci juvenil well adult recov indic speci reproduc pet trade support notion invas potenti area outsid natur rang descript report speci highlight possibl introduct alien speci japan facilit monitor | D058865 | T098 |
34,664,922 | new speci sea whip gorgonian associ zoantharian cnidaria anthozoa hexacorallia parazoanthida ryukyu island japan subgener subdivis genus umimayanthus symbios invertebr common ocean although usual divers specif interact well understood parazoanthida cnidaria anthozoa zoantharia one divers zoantharian famili term number genera speci speci famili common associ various invertebr util substrat previous studi organ taxonomi parazoanthida reveal strong specif mani parazoanthid speci genera substrat howev understand speci divers parazoanthida far complet parazoanthid often overlook sampl survey studi establish three subgenera genus umimayanthus montenegro sinnig reimer nominotyp umimayanthus paraumimayanthus subgen nov gorgoniazoanthus subgen nov base find new speci umimayanthus gorgoniazoanthus kanabou sp nov associ sea whip gorgonian ellisella sp approxim depth shallow mesophot coral reef communiti oura bay okinawajima island oshima strait near amami oshima island ryukyu island southern japan addit report gastropod crustacean observ associ u kanabou speci thought potenti prey upon zoantharian gorgonian polyp umimayanthus kanabou phylogenet close relat congener spong associ umimayanthus spp support recent hypothesi substrat prefer may chang evolutionari histori zoantharian | D013045 | T070 |
34,664,919 | reproduct mesobiotus comparison morpholog behavior famili macrobiotida tardigrada eutardigrada genus mesobiotus separ genus macrobiotus name refer phylogenet posit among famili macrobiotida howev knowledg reproduct behavior genus limit compar paramacrobiotus macrobiotus studi comprehens provid reproduct trait includ gamet morpholog behavior observ mesobiotus morpholog spermatozoon show length intermediari among paramacrobiotus macrobiotus speci sequenc mate behavior general conserv three speci macrobiotida show describ five step observ paramacrobiotus macrobiotus howev male mesobiotus repeat ejacul mate session first observ prematur ejacul tardigrad result indic mesobiotus potenti model show linkag genera respect morpholog behavior famili macrobiotida | D012726 | T054 |
34,664,916 | parasit induc intersexu sexual dimorph varunid crab ptychognathus ishii decapoda varunida although mani anim perform sexual reproduct exhibit sexual dimorph individu intersex trait trait male femal appear speci depend environment factor ptychognathus ishii varunid crab exhibit distinct sexual dimorph morpholog abdomen chelip setal tuft chelip studi howev report first time intersex individu intermedi charact male femal occasion found wild popul morpholog featur intersex individu describ taxonom posit identifi base dna sequenc part mitochondri cytochrom c oxidas coi gene shown intersexu induc entoniscid parasit intersex individu parasit entoniscid isopod identifi entionella sp appar correl parasit morpholog anomali suggest parasit isopod affect physiolog condit lead femin male host | D012727 | T032 |
34,664,914 | phenotyp plastic salamand hatchl pre feed stage respons futur prey vulner anim immedi hatch may induc plastic earli ontolog becom import subsequ surviv growth ezo salamand hynobius retardatus amphibian inhabit pond hokkaido japan ezo brown frog rana pirica spawn occas salamand larva must achiev suffici size order success captur frog tadpol examin whether presenc tadpol caus develop greater bodi andor gape size newli hatch salamand larva turn result advantag futur prey predat interact examin hypothesi conduct three laboratori experi demonstr phenotyp plastic salamand hatchl respons presenc absenc frog tadpol screen type signal involv express phenotyp plastic first salamand hatchl rear alon tadpol growth morpholog trait hatchl compar result show hatchl larva grew faster develop gape presenc tadpol next identifi type signal induc plastic two separ experi manipul chemic visual signal tadpol conduct find show faster growth develop gape induc chemic visual signal plastic may adapt strategi increas likelihood prey tadpol futur prey predat interact | D000222 | T040 |
34,664,913 | plain bodi octopus callistoctopus aspilosomati learn object via visual tactil sensori input pilot studi although various recogn abil reveal octopus predomin deal speci therefor cognit divers among octopus speci overlook need investig investig whether plain bodi octopus learn symbol stimulus reason octopus abund around okinawa island complex coral communiti landscap attent paid whether octopus learn stimulus base sole visual inform without previous experi learn tactil well visual furthermor examin whether differ sensori input affect learn octopus first test whether octopus condit three differ stimuli object pictur video white cross octopus present object pictur could learn touch howev octopus present video could learn touch stimulus second show video octopus alreadi learn object pictur investig whether octopus experienc target use visual tactil sens recogn video target base sole visual inform octopus could learn touch video condit stimulus novel stimulus simultan present comput screen octopus learn object often select condit stimulus compar octopus experienc pictur find suggest octopus use multisensori inform recogn specif object | D007858;D014110;D014796 | T061;T062;T042;T041 |
34,664,912 | italian gynecolog begin twentieth centuri analysi medic record institut direct luigi mangiag histori modern italian gynecolog close relat figur enlighten clinician passion master luigi mangiag good reason consid one father disciplin mangiag found obstetr gynecolog institut milan direct structur aim paper describ aspect italian gynecolog begin twentieth centuri analysi origin medic record date back year fragment real life women midwiv doctor pioneer era obstetr gynecolog | D006176;D008880;D009774 | T091;T097 |
34,664,910 | relationship exercis capac grip strength cohort older cardiac outpati progress age popul highlight import relationship physic function frailti patient chronic diseas aim studi assess associ exercis capac grip strength gs cohort older patient involv exercis base secondari prevent program | D005080;D017079 | T060;T201 |
34,664,909 | injuri pattern base player posit japanes univers handbal cross section studi player although evid risk injuri handbal vari accord player posit unclear whether characterist injuri also differ aim studi character compar posit associ injuri profil univers handbal player japan | D001265;D013177 | T056;T037 |
34,664,908 | physic characterist elit camogi player aim current investig establish posit physic characterist elit intercounti camogi player compar current femal field sport athlet norm | D054874 | T055 |
34,664,907 | aerob combin water base train older women effect strength cardiorespiratori outcom aim present studi investig muscular cardiorespiratori adapt two water base train program older women | D000072599;D055070 | T040;T061 |
34,664,895 | impact proton pump inhibitor sar cov pneumonia identif risk factor sever outcom sar cov infect import issu covid manag much attent focus comorbid well drug taken patient usag proton pump inhibitor ppis appear potenti influenc diseas cours drug known reduc stomach acid also modul immun system use prior covid infect seem predispos develop sever pneumonia therefor greater risk mortal instead use histamin receptor antagonist hras seem associ better outcom patient covid term symptom risk intub death ppis essenti treatment mani disord usag drug balanc consid benefit risk ratio order guarante correct use necessari time remain clarifi whether detriment effect term covid sever outcom due ppis under diseas administ new control random trial requir better understand impact sar cov infect vanvitellimonaldi covid group adriano cristinziano carolina dell donn cecilia calabres fabio perrotta filippo scial francesco lassandro gennaro mazzarella giorgio paoli leonardo de luca maria galdo miriam buonincontro roberta cianci rosalba donizzetti stefano sanduzzi zamparelli tullio valent vito dagnano vittorio bisogni | D000086382;D054328 | T047;T121;T067 |
34,664,892 | associ role conflict ambigu stress among nurs primari health care center saudi arabia coronavirus diseas pandem cross section studi studi aim assess associ role conflict ambigu among nurs primari healthcar center phcs saudi arabia stress level coronavirus diseas covid pandemicin onlin cross section studi sociodemograph occup characterist role conflict ambigu nurs assess use bowl scale role conflict ambigu stress assess use item perceiv stress scale septemb octob logist regress use calcul odd ratio or confid interv cis median stress level nurs averag high nd rd tertil role conflict ambigu compar nurs low role conflict ambigu st tertil mean standard deviat age nurs year male adjust phc type work hour nurs averag high role conflict signific higher stress rate low role conflict or cis respect similar nurs averag high role ambigu signific higher stress low role ambigu or cis respect increas stress rate detect across increas categori role conflict ambigu p valu trend found role conflict ambigu associ stress among nurs phcs saudi arabia covid pandem | D024802 | T054 |
34,664,885 | time first tumor manifest diagnosi patient gep net result larg german tertiari referr center patient neuroendocrin tumor net often go long phase onset symptom initi diagnosisassess time diagnosi pre clinic pathway patient gastroenteropancreat net gep net regard metastas symptomsretrospect analysi patient gep net tertiari referr center inclus criteria patient year diagnosi gep net statist analysi use non parametr methodsfour hundr eighti six patient tumor identifi median age first diagnosi unknown year male patient pancreat net tumor small intestin net tumor patient show net specif patient tumor specif symptom patient distant metastas initi diagnosi liver metastas gep net incident find median time tumor manifest eg symptom relat net initi diagnosi across entiti ci day signific differ patient without distant metastas median vs day p larg proport gep net incident find half patient symptomat time diagnosi find signific influenc presenc metastas time diagnosi show larg variabl median day | D013997 | T079 |
34,664,883 | immedi famili support import discharg home cancer patient bone metastasi rehabilit retrospect studi purpos studi investig predict factor home discharg rehabilit patient cancer bone metastasiscanc patient bone metastasi underw rehabilit april march retrospect enrol data discharg destin collect medic record outcom multipl regress analys carri investig predict factor home dischargenineti eight patient mean age year femal male includ fifti patient discharg home patient discharg facil patient die skelet relat event among patient hospit stay receiv oper curv predict factor home discharg barthel index admiss eastern cooper oncolog group perform status admiss number immedi famili member live home point area curv auc sensit specif score auc sensit specif famili member auc sensit specif respectivelyin order plan cancer patient bone metastasi discharg home import take consider patient barthel index perform status time hospit admiss number immedi famili member live home | D011369 | T054 |
34,664,881 | impact air temperatur occurr bath relat cardiac arrest mortal bath relat cardiac arrest brca extrem high air temperatur report associ brca occurr unclear whether daili minimum temperatur differ maximum minimum air temperatur influenc brca occurr mosta retrospect cohort studi adult patient conduct januari februari hirosaki univers hospit emerg depart follow data collect age sex day cardiac arrest event locat event initi cardiac rhythm presenc return spontan circul overal mortal status month cardiac arrest event base day event locat event occur daili minimum maximum temperatur obtain japan meteorolog agenc databasea total elig cardiac arrest case identifi includ case brca compar brca non brca initi shockabl cardiac rhythm vs presenc return spontan circul vs overal mortal vs differ signific p daili minimum maximum temperatur show signific relationship brca non brca daili minimum temperatur risk factor brca occurr adjust age temperatur differ risk ratio confid interv daili minimum temperatur repres potenti risk factor brca occurr | D013696 | T081 |
34,664,880 | incid mump taiwan associ meteorolog paramet observ studi mump acut common childhood diseas caus paramyxovirus report occurr mump influenc season howev role meteorolog variabl incid mump remain unclear purpos studi explor relationship meteorolog factor incid mump infect poisson regress analysi use studi relationship weather variabl incid mump taiwan case mump case report center diseas control taiwan taiwan cdc occurr mump virus infect reveal signific season spring summer season taiwan incid mump virus infect began increas temperatur c start declin temperatur higher c r p similar number mump case began increas relat humid r p number mump case posit associ temperatur relat humid period preced infect studi show occurr mump signific associ increas temperatur relat humid taiwan therefor factor could regard earli warn signal indic need strengthen intervent prevent mump | D008685 | T070 |
34,664,872 | efficaci fish oil prevent coronari heart diseas systemat review meta analysi coronari heart diseas chd one common caus death diseas burden world current fish oil aim prevent treat chd shown larg varieti effect low level evid | D002985 | T062;T061 |
34,664,871 | comparison effect left atrial appendag closur oral anticoagul prevent stroke patient non valvular atrial fibril protocol systemat review meta analysi studi aim analyz evalu differ efficaci left atrial appendag closur laac oral anticoagul oa prevent stroke patient non valvular atrial fibril nvaf method meta analysi purpos provid prevent stroke patient nvaf valuabl treatment guidanc | D002985 | T062;T061 |
34,664,870 | effect baduanjin fall balanc function middl age elder peopl protocol systemat review meta analysi risk fall serious affect health qualiti life middl age elder peopl especi injuri disabl caus fall middl age elder peopl impos huge burden famili social medic care baduanjin exercis may effect intervent enhanc muscl strength stabil lower limb improv balanc abil gait middl age elder peopl reduc incid fall improv qualiti life promot health middl age elder peopl aim studi summar evid systemat review efficaci safeti baduanjin fall balanc function middl age elder peopl | D002985 | T062;T061 |
34,664,868 | gastric empti preoper carbohydr elder assess use gastric ultrasonographi random control studi preoper carbohydr load enhanc postop recoveri reduc patient discomfort howev gastric empti liquid delay elder popul therefor studi aim evalu gastric empti ml carbohydr drink ingest hour surgeri elder patient | D057234 | T079 |
34,664,867 | impact wear person protect equip perform decis make surgeon covid pandem observ cross section studi coronavirus diseas covid pandem mandatori use person protect equip ppe result signific reduct infect rate among health care worker hcws howev ongo concern negat impact use ppe prolong periodsthi studi examin impact wear ppe surgeon perform decis make covid pandemicin cross section studi anonym onlin questionnair creat dissemin surgeon eastern provinc saudi arabia questionnair includ demograph data local hospit polici non technic skill eg communic vision comfort technic skill process decis makingfrom june august surgeon particip questionnair age year receiv special train ppe particip oper covid confirm case negat impact wear ppe report overal comfort vision communic skill respect technic skill decis make signific affect respect prefer conserv approach damag control procedur andor open approach reporteddespit benefit ppe associ signific negat impact non technic skill includ vision communic comfort well non signific negat impact technic skill decis make surgeon extra effort direct improv ppe especi lengthi pandem | D003657 | T041 |
34,664,863 | associ clinic phenotyp dermatomyos polymyos myositi specif antibodi overlap system autoimmun diseas aim studi evalu associ clinic phenotyp dermatomyos dm polymyos pm myositi specif antibodi msas overlap diagnosi system autoimmun diseasesthi cross section studi conduct patient dm patient pm recruit region hospit southern taiwan clinic phenotyp dm pm assess msas measur use commerci line blot assay associ clinic phenotyp dm pm msas overlap diagnosi system autoimmun diseas perform use univari multipl logist regress analysesclin patient dm pm overlap diagnosi system sclerosi associ higher risk interstiti lung diseas ild odd ratio p raynaud phenomenon p malign p risk malign also associ older age p male patient associ higher risk fever msas anti aminoacyl trna synthetas antibodi associ ild antinuclear antibodi associ lower risk arthriti anti transcript intermediari factor gamma antibodi associ milder symptom muscl weak anti ku antibodi associ overlap diagnosi system lupus erythematosus anti ro antibodi associ develop raynaud phenomenon sjgren syndromemsa overlap diagnosi system sclerosi signific associ clinic phenotyp dm pm physician vigil malign older dm pm patient overlap diagnosi systeic sclerosi possibl develop ild patient overlap diagnosi system sclerosi serum posit anti aminoacyl trna synthetas antibodi consid | D010641 | T032 |
34,664,861 | construct immun relat lncrna base prognost model nsclc via bioinformat particip tumorigen oncogen tumor suppress pathway gene express regul aim build immun relat long noncod rna lncrna prognost model enhanc nonsmal cell lung cancer nsclc prognost predictionth origin data collect cancer genom atlas databas perl r softwar use statist analysi effect lncrnas express prognosi analyz gene express profil interact analysi silico function analysi perform david bioinformat resourcesth median risk score divid valu separ patient high low risk group group differ year surviv rate median surviv time immun status lncrna signatur valid independ prognost factor high accuraci area receiv oper characterist silico function analysi connect lncrnas immun relat biolog process pathway carcinogenesisth novel immun relat lncrna prognost model signific clinic implic enhanc lung adenocarcinoma outcom predict guid choic treatment | D011379 | T058;T201 |
34,664,860 | prognost valu pretreat anemia patient soft tissu sarcoma meta analysi anemia one common manifest patient cancer recent multipl studi shown posit correl pretreat anemia tumor prognosi yet relationship pretreat anemia prognosi soft tissu sarcoma sts unclear | D011379 | T058;T201 |
34,664,857 | chines medicin therapi neurogen bladder spinal cord injuri protocol systemat review network meta analysi neurogen bladder nb refractori diseas character void dysfunct bladder andor urethra spinal cord injuri sci common caus chines medicin therapi appli extens treatment nb especi china result promis vari thus aim work assess efficaci safeti various chines medicin therapi nb sci | D002985 | T062;T061 |
34,664,850 | novel system teach plane vascular access techniqu simul studi long axi plane approach amen ultrasound guid central venous catheter howev long axi plane approach consid difficult learn needl remain visibl ultrasound beam procedur develop novel compet base modular system acquir skill long axi plane approach purpos studi evalu efficaci systemth studi approv local ethic committe particip perform ultrasound guid venous catheter pre test attend hour hand session teach system evalu posttest teach system simul devic consist ultrasound probe simul vessel needl endoscop connect comput visual imag insid simul vessel success rate visual needl tip punctur accuraci measur train punctur accuraci determin evalu distanc needl tip needl shaft center simul vessel primari outcom success rate punctur accuraci secondari outcom needl tip visual mcnemar test use analyz success rate needl tip visual tukey test use analyz punctur accuraci p valu consid statist significantforti seven particip enrol studi success rate signific increas pre test posttest p ultrasound imag particip analyz punctur accuraci punctur accuraci signific increas needl tip distanc p shaft distanc p needl tip visual signific improv p novel compet base teach system construct step step manner improv needl tip visual punctur accuraci higher success rate | D016544;D062666 | T065;T074 |
34,664,847 | efficaci safeti shenfu inject treatment sepsi protocol systemat review meta analysi sepsi syndrom infect induc system inflammatori respons convent treatment combin shenfu inject sfi previous valid clinic effect allevi inflammatori respons patient septic shock howev evid base medic evid scant herein design protocol propos studi base prefer report item systemat review meta analys guidelin aim systemat evalu efficaci safeti sfi patient sepsi | D002985 | T062;T061 |
34,664,840 | coffe consumpt associ decreas risk incid chronic kidney diseas protocol systemat review meta analysi recent studi suggest renal protect effect coffe consumpt develop chronic kidney diseas ckd although result remain inconclus perform protocol systemat review meta analysi comprehens investig associ summar avail data | D002985 | T062;T061 |
34,664,839 | evalu efficaci safeti propofol treatment procedur sedationanesthesia neonat protocol systemat review meta analysi newborn propofol anesthesia common util propofol increas shown effect safe treat procedur sedat anesthesia neonat research aim evalu efficaci safeti propofol neonat use systemat review meta analysi methodolog | D002985;D020377 | T062;T041;T061 |
34,664,836 | cross section analysi diagnosi manag chronic obstruct pulmonari diseas peopl live hiv opportun improv chronic obstruct pulmonari diseas copd common peopl live hiv plwh sought evalu appropri copd diagnosi manag plwh compar result hiv uninfect personsw conduct cross section analysi veteran enrol examin hiv associ lung emphysema studi particip underw spirometri enrol report respiratori symptom self complet survey primari outcom misdiagnosi diagnosi copd frequenc appropri inhal prescript misdiagnosi defin intern classif diseas icd diagnosi copd without spirometr airflow limit post bronchodil forc expiratori volum second fev forc vital capac fvc diagnosi defin spirometri defin copd without prior icd diagnosisth analyt cohort includ plwh hiv uninfect particip plwh icd diagnosi copd misdiagnos plwh spirometri defin copd diagnos plwh diagnos copd report respiratori symptom among plwh icd copd diagnosi well spirometri defin copd long act inhal particular long act bronchodil beta agonist muscarin antagonist prescrib infrequ even symptomat individu inhal corticosteroid frequent prescrib long act inhal plwh result overal similar amongst hiv uninfectedcopd frequent misdiagnos diagnos plwh similar uninfect veteran among plwh copd like indic therapi long act inhal prescrib infrequ particular guidelin concord first line long act bronchodil although first line control therapi copd inhal corticosteroid prescrib often | D058996 | T057 |
34,664,834 | comparison continu infus intermitt bolus furosemid acut heart failur protocol systemat review meta analysi acut heart failur hf common caus hospit admiss studi aim compar continu infus intermitt bolus furosemid treat acut hf | D002985 | T062;T061 |
34,664,822 | meatal stenosi atop condit pilot studi demonstr possibl unidentifi etiolog meatal stenosi ms known one frequent complic circumcis present studi aim find possibl relationship ms allerg disord total children meansd age year refer ms atop background even one famili member group also age match control meansd age year refer center allerg symptom urinari complaint group b n rida qline allergi allergi explor alex test perform patient find possibl allergen sensit laboratori find reveal ige sensit main food aeroallergen group chief complaint ms mild atop condit found concis medic histori take similar control group signific differ except ryegrass higher control group although total ige level consider higher group b compar group food sensit cow milk lactoglobulin higher asthmat patient group compar control seem patient ms consid complic circumcis undergo surgic procedur correct stenosi investig requir determin role concis medic histori take proper treatment allerg disord reduc fail surgic attempt atop boy ms | D004198 | T201 |
34,664,818 | investig correl growth differenti factor serum level gene express psoriasi sever psoriasi chronic inflammatori dermat character inflammatori epiderm hyperprolifer growth differenti factor gdf member transform growth factor famili immun modulatori role autoimmun condit psoriasi studi aim evalu relationship gdf serum level well gene express psoriasi sever case control studi perform patient psoriasi vulgari healthi individu sever diseas determin base psoriasi area sever index pasi score serum level gdf measur enzym link immunosorb assay elisa gene express peripher blood mononuclear cell quantifi real time polymeras chain reaction rt pcr mean serum level gdf patient control ngml ngml respect gdf gene express measur patient group healthi group mean gdf serum level mild moder sever case psoriasi ngml respect indic elev serum level gdf correl signific diseas sever mean gdf gene express mild moder sever form psoriasi respect indic signific relationship gdf gene express psoriasi sever base studi psoriat patient gdf serum level gene express signific higher healthi control valu correl diseas activ especi sever case therefor gdf may use prognost marker psoriasi | D015415;D015870 | T080;T045;T201 |
34,664,817 | induct system lupus erythematosus like syndrom balbc mice lead disturb splenic cell subpopul mechan under system lupus erythematosus sle yet elucid studi evalu balanc cell subset balbc mice model sle induc use con polyamin dna immunogen modifi balbc mice immun subcutan g extract dna cell cultur differ condit splenocyt polyamin group p splenocyt con group splenocyt polyamin con group pa splenocyt control anti doubl strand dna ds dna antibodi proteinuria antinuclear autoantibodi assess enzym link immunosorb assay bradford method immunofluoresc respect transcript factor differ helper subset examin real time polymeras chain reaction serum level anti dsdna antibodi group pa higher group p antinuclear antibodi ana titer increas group pa proteinuria level group pa signific higher control group p result reveal increas ratio th th decreas express foxp group group pa manifest obvious sign diseas result suggest mechan rather disturb cell balanc may involv develop diseas symptom | D004198 | T201 |
34,664,816 | studi effect n acetylcystein inflammatori biomark diseas activ score patient rheumatoid arthriti rheumatoid arthriti ra consid autoimmun relat condit overproduct pro inflammatori cytokin lead inflammatori cascad n acetylcystein nac potent anti inflammatori anti oxid agent aim explor impact oral nac cytokin activ clinic indic ra patient placebo control random doubl blind clinic trial activ ra patient alloc either nac mg twice day placebo group add therapi routin regimen week diseas activ score erythrocyt sediment rate das esr serum concentr interleukin il il assess baselin end trial particip test control group reduct das esr higher consider nac group compar control group statist signific differ seen reduct il il cytokin nac control group addit improv patient global assess number tender joint number swollen joint esr rate favor nac group find reveal nac may benefici effect clinic featur ra howev non signific variat il il level suggest altern way nac effect without influenc measur cytokin nevertheless result need confirm investig | D015415 | T080;T201 |
34,664,815 | evalu ankylos spondyl transcriptom oxid phosphoryl pathway share pathway neurodegen diseas ankylos spondyl system inflammatori disord joint enthes recent studi report increas preval dementia patient howev data explor associ dementia remain uncertain studi enrich pathway differenti express gene deg identifi whole blood transcript data patient obtain gene express omnibus geo databas use gene set enrich analysi gsea differenti express analysi four pathway includ oxid phosphoryl alzheim parkinson huntington diseas signific enrich patient compar control identifi common gene among pathway show increas trend compar control five includ coxb ndufb atppf uqcrb nduf signific gene select gene express analysi use real time pcr rna content peripher blood mononuclear cell pbmcs patient control sampl group gene express analysi indic consider overexpress coxb p atpj p gene patient group comparison control sampl role oxid phosphoryl previous establish dementia pathogenesi given patient also remark higher preval dementia healthi counterpart henc result may propos common pathway oxid phosphoryl regard possibl share contribut factor etiopathogenesi dementia | D053858;D010085;D059467 | T086;T044;T169;T081 |
34,664,814 | immunomodulatori effect adipos deriv mesenchym stem cell epitheli cell function respons vibrio cholera co cultur model inflamm induc interact vibrio cholera epitheli cell consid main caus bacteria spread gastrointestin tract consequ immunomodulatori antibacteri properti adipos deriv mesenchym stem cell ad mscs studi aim investig effect ad mscs interact bacteri epitheli cell caco differenti intestin epitheli cell co cultur ad mscs ratio surfac area six well plate hour exposur vibrio cholera bacteri attach intern evalu secret interleukin il prostaglandin e pge nitric oxid also measur use elisa griess assay respect addit express chloratoxin ctx inflammatori cytokin tnf il il evalu real time polymeras chain reaction rt pcr rate apoptosi also evalu annexin v pi flow cytometri bacteri attach ctx express signific reduc co cultur group compar vibrio cholera expos caco il pge secret increas co cultur group also slight reduc exposur vibrio cholera elev level bacteri intern observ co cultur group compar caco cell lead increas express pro inflammatori cytokin rate apoptosi also increas signific cell cell contact ad mscs caco promot inflammatori respons disrupt epithelium barrier enhanc bacteri invas may due high express surfac matrix metalloproteinas mscs | D056747 | T061 |
34,664,812 | design dna vaccin base secretori form major capsid protein human papillomavirus type cervic cancer associ human papillomavirus hpvs worldwid current hpv vaccin safe high immunogen effect immun specif hpv type howev dna vaccin new appeal platform consid design hpv vaccin studi aim construct recombin eukaryot express plasmid contain l hpv tissu plasminogen activ tpa pan hla dr bind epitop padr gene pvax vector l tpa padr gene amplifi thermocycl polymeras chain reaction pcr product clone insert gene confirm use coloni pcr restrict enzym analysi sequenc method indirect immunofluoresc rt pcr western blot assay appli identifi target gene hek cell total igg isotyp immun mice measur enzym link immunosorb assay techniqu western blot analysi show protein band kda supernat cell lysat transfect cell result mice immun differ construct group pvax l group pvax tpa padr l group pvax group pbs control indic pvax tpa padr l construct induc signific higher level total igg pvax l p conclus pvax tpa padr l recombin plasmid high immunogen construct suggest promis candid vaccin develop hpv type low middl incom countri | D000087506 | T062 |
34,664,811 | atopi patch test diagnosi food allergen infant allerg proctocol compar eliminationintroduct c allerg proctocol cell depend food allergi present breast formula fed infant presenc blood differ amount stool main manifest diseas differ result publish accuraci specif atop patch test apt purpos studi evalu result apt compar obtain food eliminationintroduct ei challeng gold standard confirm allergi twenti eight patient boy girl year allerg proctocol recruit studi mean age diseas onset enrol studi month respect perform apt fresh food ei challeng done patient posit test result analyz apt posit individu common food detect apt individu milk rice soy egg white ei challeng apt posit individu milk rice egg white soy apt posit half infant year allerg proctocol signific correl apt result ei challeng test food compar result apt ei challeng method show converg milk rice sensit thus suppos apt use tool identifi two allergen cell mediat food allergi like allerg proctocol | D010328 | T060 |
34,664,810 | studi effect vitamin immunopatholog respons bronchi murin model asthma allerg asthma complic respiratori problem character airway inflamm airway hyperrespons ahr breathless mucus hyper secret goblet cell hyperplasia asthma control genet environment factor allergi main trigger asthma mediat th cytokin along ige product vitamin vit main supplementari factor immun system present studi investig effect vit exacerb allerg asthma murin model allerg asthma induc ovalbumin ova four five group studi femal balbc mice group n one group consid control ova induc mice two group receiv vit via oral iukg diet intranas inhal form min day third group receiv budesonid least ahr level il il il inf g bronchoalveolar lavag fluid balf serum ige histamin il il gene express well histopatholog studi lung done penh valu type cytokin balf protein molecular level total ige histamin perivascular peribronchi inflamm goblet cell hyperplasia mucus hypersecret decreas signific oral intranas vit treat asthmat mice group especi day oral treat mice found vit promis agent control allerg asthma remark abil decreas sever inflamm therefor vit suffici high recommend asthmat patient | D004198 | T201 |
34,664,809 | convent sternotomi versus right mini thoracotomi versus robot approach mitral valv replacementrepair insight network meta analysi minim invas cardiac surgeri mic right mini thoracotomi well robot surgeri emerg last decad mitral valv surgeri howev risk benefit fulli understood yet thus conduct network meta analysi compar earli long term outcom mitral valv surgeri via convent sternotomi mic robot approach | D006348;D065287 | T061 |
34,664,807 | knowledg cardiovascular diseas risk percept perspect prison staff scottish prison qualit studi prison increas risk cardiovascular diseas cvd compar general popul knowledg risk percept cvd influenc engag prevent behaviour lower individu cvd risk paper aim explor prison knowledg cvd prison staff percept prison cvd risk | D002318;D011329 | T047;T098 |
34,664,803 | simultan nosocomi sar cov outbreak differ pattern occurr two general ward experi tertiari care hospit korea nosocomi outbreak sever acut respiratori syndrom coronavirus occur two general ward one outbreak pre symptomat transmiss link epidemiolog index case outbreak associ earli detect failur crowd room notabl adher appropri mask wear confirm hospit outbreak confirm case move isol room contact quarantin quarantin case test regular facilit earli termin hospit outbreak | D000086402 | T005 |
34,664,800 | innat type respons aspergillus fumigatus murin model atop dermat like skin inflamm atop dermat ad chronic relaps inflammatori skin diseas mediat helper type th cell acut phase group innat lymphoid cell ilc play role initi th respons although mold exposur associ develop ad studi under mechan lack studi investig whether group ilc involv inflamm ad like skin induc aspergillus fumigatus af | D007113 | T032 |
34,664,799 | preclin evalu novel polym free everolimus elut stent mid term porcin coronari restenosi model titanium dioxid film exhibit good biocompat may effect drug bind matric drug elut stent conduct mid term evalu novel polym free everolimus elut stent use nitrogen dope titanium dioxid film deposit tigerevolut comparison commerci durabl polym everolimus elut stent xienc alpin porcin coronari restenosi model | D054855 | T074 |
34,664,798 | evalu adher guidelin heart failur reduc eject fraction heart failur preserv eject fraction without atrial fibril studi evalu relationship guidelin adher heart failur hf reduc eject fraction hfref discharg relev clinic outcom patient acut hf preserv eject fraction hfpef without atrial fibril af | D055118 | T033;T081;T055 |
34,664,797 | ventil chang children home mechan ventil affect philip respiron trilog ventil recal philip respiron recal notif issu june affect mani posit airway pressur devic mechan ventil includ trilog ventil often util children use home posit pressur ventil via tracheostomi ppv optim strategi replac ventil children use home ppv affect philip recal unknown conduct retrospect studi children use home ppv recal trilog ventil underw inpati ventil chang non recal portabl home ventil phv use collabor institut protocol studi period children use ppv recal trilog ventil patient underw inpati ventil chang either elect hospit n unschedul postop hospit n median durat hospit ventil chang day interquartil rang day general day patient admit sole ventil chang children use ppv recal trilog ventil systemat protocol collabor patient physician durabl medic equip compani may optim transit nonrecal phvs | D006699;D012121 | T058;T061 |
34,664,796 | potenti util longitudin somat mutat methyl profil predict molecular residu diseas postop non small cell lung cancer patient grow effort invest investig various molecular approach detect minim residu diseas mrd predict diseas recurr studi investig util parallel longitudin analysi mutat dna methyl profil predict mrd postop non small cell lung cancer nsclc patient tumor tissu longitudin blood sampl obtain patient resect stage ia iiib nsclc somat mutat dna methyl profil perform use ultra deep target sequenc target bisulfit sequenc respect dynam chang plasma base mutat tumor inform methyl profil reflect mrd score observ surgeri baselin postop follow reflect decreas tumor burden patient resect nsclc mutat detect plasma sampl patient baselin signific reduc post oper follow up mrd score posit rate baselin reduc first second follow among relaps patient parallel longitudin analysi mutat methyl profil elev mrd score observ follow month prior radiolog recurr patient patient also concomit increas allel fraction mutat least follow time point one patient mutat detect throughout follow up result demonstr longitudin profil mutat dna methyl may potenti detect mrd predict recurr postop nsclc patient | D019175 | T044 |
34,664,795 | assess incid risk factor earli poststrok seizur lebanes patient earli seizur recogn serious complic ischem stroke data limit among lebanes patient studi aim assess incid risk factor earli seizur postischem stroke determin effect earli seizur function outcom among lebanes stroke patient | D012640;D020521 | T047;T184;T046 |
34,664,786 | nurs student experi appli problem base learn train core compet teamwork collabor interview studi explor nurs student experi appli problem base learn train core compet teamwork collabor | D013338 | T097 |
34,664,785 | evalu interrel autism polygen score psychiatr famili histori risk autism psychiatr famili histori high autism polygen risk score prs separ link autism spectrum disord asd risk studi aim simultan consid psychiatr famili histori individu autism genet liabil prs autism risk perform case control studi denmark singleton birth may decemb denmark first birthday known mother case diagnos asd control compris random sampl birth without asd exclud person non denmark born parent miss asd prs non european ancestri adjust odd ratio aor estim asd prs decil psychiatr histori parent full sibl mutual exclus categori use logist regress adjust asd prs z score least squar mean estim psychiatr famili histori categori asd risk asd case control asd prs substanti alter account psychiatr famili histori eg asd prs th decil aor ci vs ci adjust psychiatr famili histori account asd prs eg asd famili histori aor ci vs ci adjust asd risk asd prs vari slight psychiatr famili histori asd risk psychiatr famili histori account asd prs vice versa risk overlap two factor like increas measur genet risk improv two factor best view complementari measur famili base autism risk lay summari autism risk histori mental disord immedi famili explain measur individu genet risk autism polygen risk score vice versa genet risk appear overlap famili histori risk genet measur autism improv overlap autism risk famili histori versus genet factor like increas studi may need fulli determin compon risk inter relat key famili factor meanwhil two factor may best view complementari measur autism famili base risk | D000067877;D001321 | T048 |
34,664,783 | novel upregul lncrna ac promot chemo resist predict poor prognosi acut myeloid leukemia aml common hematolog malign poor prognosi pathogenesi still unclear lncrna take part occurr develop aml research aim explor new differenti express lncrnas effect aml | D015973 | T045 |
34,664,782 | sar cov acut bronchiol hospit children neither frequent sever endem coronavirus found acut bronchiol main coinfect virus sever acut respiratori syndrom coronavirus sar cov respons respiratori ill hospit children characterist patient bronchiol extens describ | D001988;D000086382 | T047;T067 |
34,664,778 | collect use porewat data sediment bioassay studi understand exposur bioavail metal us environment protect agenc procedur deriv equilibrium partit sediment benchmark esb protect benthic organ metal mixtur cadmium copper lead nickel silver zinc equilibrium partit approach causal link metal concentr toxicolog effect appli sediment porewat ie interstiti water evalu bioavail metal concentr porewat use tool biotic ligand model provid advanc complement sediment base evalu howev porewat character less common perform sediment bioassay sediment chemistri character due difficulti expens porewat collect well concern interpret porewat data studi discuss advantag disadvantag differ porewat extract method analysi metal bioavail paramet laboratori sediment bioassay focus peeper centrifug purpos provid recommend generat bioassay porewat data suffici qualiti use risk base decis make regul cleanup action comparison pair data previous bioassay studi indic metal porewat concentr collect via centrifug tend higher collect via peeper howev centrifug disrupt redox status sediment also metal concentr vari mark base centrifug condit data compar concentr peeper centrifug collect bioavail paramet eg major ion ph much limit indic smaller differ observ metal concentr peeper sampl without alter redox status porewat small volum porewat peeper collect enough metal concentr analysi insuffici analysi metal bioavail paramet given benefit metal collect via peeper optim use centrifug peeper tandem bioassay porewat collect improv bioavail predict environ assess manag setac | D019015;D014874 | T070;T131;T068 |
34,664,777 | physic teen date violenc high school student slovenia preval correl although teen date violenc tdv intern recogn serious threat adolesc health well almost data avail slovenian youth henc purpos studi examin preval predictor tdv among slovenian adolesc first time use data spmad studi studi parent monitor adolesc delinqu high school student ask physic tdv victim perpetr well date histori relationship conflict peer antisoci behavior inform social control famili school substanti number femal male adolesc report victim femal male respond perpetr femal male respond furthermor result reveal lower age first relationship relationship conflict school inform social control associ victim wherea femal relationship conflict antisoci peer famili inform social control link perpetr implic studi find discuss | D000294;D000066511 | T053;T055 |
34,664,776 | circ snap hsacirc mir p regul wee regul chemoresist growth invas ddp toler nsclc cell via cerna pathway circular rna synaptosom associ protein circ snap hsacirc oncogen non small cell lung cancer nsclc howev role undescrib cis diamminedichloroplatinum ii ddp resist attempt investig express role mechan ddp toler nsclc result circ snap express upregul human ddp toler nsclc tissu cell accompani wee g checkpoint kinas wee upregul microrna mir p downregul function interf circ snap andor restor mir p curb inhibitori concentr ddp coloni format cell prolifer invas accompani apoptot rate promot depress multidrug resist mdr marker mdr mrp anti apoptosi protein bcl pro invas protein mmp notabl circ snap interfer suppress xenograft tumor growth ddp toler nsclc cell elev mir p descend wee mechanist circ snap direct target mir p mir p target wee therefor circ snap mir p wee axi might particip chemoresist progress ddp toler nsclc | D002289;D018797;D008175;D035683;D011505 | T191;T116;T123;T114;T126 |
34,664,772 | effect dronedaron atrial fibrosi progress atrial fibril recurr postabl design edora random clinic trial atrial fibril af recurr cathet ablat associ wors outcom qualiti life left atrial la structur remodel provid essenti substrat af perpetu baselin extent progress la fibrosi ablat strong predictor postprocedur af recurr dronedaron antiarrhythm drug proven effici maintain sinus rhythm | D001281;D017115 | T047;T061;T046 |
34,664,771 | bisphenol induc apoptosi via oxid stress generat involv nrfho pathway mitochondri depend pathway human retin pigment epithelium arp cell bisphenol bpa estrogen like compound environment hormon common use daili life therefor may enter human bodi food direct contact caus bpa residu blood urin studi focus analysi bpa reproduct cell tissu regard evid effect bpa human retin pigment epithelium arp cell unavail accord present studi explor cytotox bpa arp cell bpa treatment express bcl xl antiapoptot protein mitochondria decreas express bax proapoptot protein increas mitochondri membran potenti affect bpa chang mitochondri membran potenti led releas cytochrom c activ caspas promot downstream caspas lead cytotox nuclear factor erythroid deriv like nrf heme oxygenas ho pathway play major role age relat macular degener result show express ho nrf suppress bpa superoxid dismutas catalas nrf downstream antioxid degrad bpa amp activ kinas ampk regul phosphoryl nrf phosphoryl ampk express reduc bpa final bpa induc ros generat cytotox reduc n acetyl l cystein taken togeth result suggest bpa induc arp cell via oxid stress associ regul nrfho pathway mitochondria depend apoptot signal pathway | D051547;D051267 | T116;T126;T123 |
34,664,769 | pharmacokinet safeti novel influenza treatment baloxavir marboxil korean subject compar japanes subject baloxavir marboxil novel influenza therapeut agent prodrug rapid metabol activ form baloxavir acid inhibit cap depend endonucleas studi evalu pharmacokinet pks safeti baloxavir acid healthi korean subject compar publish data japanes subject open label singl ascend dose studi conduct korean male subject singl oral dose baloxavir marboxil mg administ eight subject addit mg administ six subject bodi weight kg noncompartment popul pk analys perform result compar japanes subject appropri bodi weight base dose regimen evalu simul pk profil baloxavir acid reveal multicompart behavior long half life h demonstr dose proport increas baloxavir acid reach peak plasma concentr h postdos bodi weight identifi signific covari appar oral clearanc appar volum distribut similar observ japanes subject bodi weight adjust analysi reveal exposur baloxavir acid signific differ korean japanes subject simul exposur baloxavir acid demonstr bodi weight base dose regimen baloxavir marboxil appropri base pk studi clinic data includ dose regimen develop japan adequ extrapol korea support approv baloxavir marboxil korean new treatment option influenza | D007251 | T047 |
34,664,768 | challeng de implement feed tube auscult qualit studi qualit studi explor de implement feed tube auscult practic adult patient critic care nurs | D064648;D007857 | T091;T054;T078 |
34,664,766 | applic amstar overview systemat review intervent mental behaviour disord cross section studi measur tool assess systemat review version amstar item tool critic apprais systemat review srs healthcar intervent studi aim assess method outcom amstar apprais overview srs intervent mental behaviour disord cross section studi conduct use overview srs select three electron databas januari data item includ overview sr characterist amstar apprais method outcom data extract two author independ narrat synthesis use descript statist mean sd relat frequenc sr characterist compar base amstar apprais outcom use chi squar test overview apprais srs predomin non pharmacolog intervent mental disord amstar apprais report confid rate overview individu item score overview srsoverview non cochran mean includ rcts mean publish amstar releas mean confid rate deriv overview srs predomin critic low confid rate similar srs rcts versus rctsnon rcts srs publish versus amstar releas cochran srs receiv highmoder lowcrit low confid rate p confid rate deriv base amstar differenti among srs healthcar intervent except cochran srs fulfil criteria high confid rate amstar item consult avoid common weak futur srs | D001523;D011642 | T048;T170;T073 |
34,664,765 | cathet ablat ventricular tachycardia patient postinfarct left ventricular aneurysm ventricular tachycardia vt set postmyocardi infarct left ventricular aneurysm lva uncommon encount scarciti data regard safeti efficaci outcom ablat vt subset patient | D017115;D006322;D009203;D017180 | T047;T061;T046 |
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