PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,664,152 | sex differ respons decept across mate valu trait attract job status altruism onlin date sex differ mate prefer well establish also well understood human often seek manipul stand import mate valu trait yet pauciti work examin potenti sex differ respons decept along import dimens studi sampl undergradu femal respond hypothet onlin date scenario ask particip rank upset would deceiv date attract occup volunteer women rank occup decept upset men men rank attract decept upset women given potenti measur differ forc choic continu respons option studi random assign undergradu femal one decept condit ask report level upset willing go date use continu respons scale women like men cancel date decept involv volunteer occup signific sex differ attract condit neither mate valu sociosexu moder sex differ level upset due decept togeth find demonstr women men exhibit differ degre becom upset opposit sex decept onlin date regardless self perceiv mate valu sociosexu align evolv sex differ mate prefer | D000533;D012727 | T032;T054 |
34,664,149 | develop valid short questionnair dietari physic activ habit patient submit bariatr endoscop therapi individu obes frequent regain weigh endoscop bariatr therapi ebt unless adher healthi habit object creat valid short self administ questionnair emov assess healthi dietari physic activ pa habit adher use clinic practic | D009767 | T047 |
34,664,148 | learn process effect covid pandem teleproctor advanc endoscop skill train endoscopist endoscop sleev gastroplasti procedur covid pandem led health institut cancel mani activ includ train differ field practic train program encourag use teleproctor altern method enhanc physician abil assur train aim evalu remot train program endoscopi sleev gastroplasti esg | D000086382;D015391;D009767 | T047;T061;T067 |
34,664,147 | function electrospun polycaprolacton scaffold matrix bind osteocyt deriv extracellular vesicl promot osteoblast differenti miner synthet polymer materi demonstr great promis bone tissu engin base compat wide array scaffold manufactur techniqu limit term bioactiv compar natur occur materi enhanc regen properti materi common functionalis bioactiv factor guid growth within develop tissu extracellular matrix vesicl ev play import role facilit endochondr ossif long bone develop recent emerg import mediat cell cell communic coordin bone regener thus repres ideal target enhanc regen properti synthet scaffold therefor paper develop tool protocol enabl attach mlo osteocyt deriv ev onto electrospun polycaprolacton pcl scaffold bone repair initi optim method function pcl materi collagen type fibronectin inspir behaviour matrix vesicl endochondr ossif demonstr effect method adhes ev materi surfac use function process attach osteogen ev collect mechan stimul mlo osteocyt collagen coat electrospun pcl scaffold ev function scaffold promot osteogen differenti measur increas alp activ miner matrix particular ev functionalis scaffold exhibit signific increas matrix miner particular earlier time point compar uncoat collagen coat control approach matrix base adhes ev provid mechan incorpor vesicl signal polyest scaffold demonstr potenti osteocyt deriv ev enhanc rate bone tissu regener | D010012;D011091;D054457 | T042;T122;T109 |
34,664,143 | malign bowel obstruct manag time anyth new current narrat review malign bowel obstruct periton carcinomatosi affect signific proport lumin gastrointestin ovarian oncolog patient portend poor long term surviv manag approach patient includ rang medic therapi surgic option howev select optim treatment strategi remain enigmat goal narrat review summar latest evid around multimod malign bowel obstruct treatment establish progress made | D007415;D010534 | T191;T047 |
34,664,141 | carbon ion radiotherapi local recurr rectal cancer patient prior pelvic irradi studi aim assess safeti efficaci carbon ion radiotherapi cirt salvag previous x ray irradi xrt local recurr rectal cancer lrrc | D063193;D012004 | T191;T061 |
34,664,139 | preoper peripher blood lymphocyt monocyt ratio predict long term outcom patient pancreat ductal adenocarcinoma although various biomark use predict cancer prognosi effect preoper system biomark pancreat ductal adenocarcinoma pdac establish studi aim evalu whether lymphocyt monocyt ratio lmr predict long term outcom patient undergo surgic resect pdac | D021441;D010190 | T191 |
34,664,136 | bone strain index predict fragil fractur osteoporot women artifici intellig base studi appli artifici intellig base model predict fragil fractur postmenopaus women use differ dual energi x ray absorptiometri dxa paramet | D058866;D016103 | T047;T037 |
34,664,134 | simultan modul nlrp inflammasom nrfare pathway rescu thioacetamid induc hepat damag mice role oxid stress inflamm chronic tissu injuri result fibrosi multipl organ respons one third death global liver fibrosi common pathwaycondit involv chronic liver diseas thioacetamid taa hepatotoxic use induc hepat fibrosi anti diabet drug glibenclamid glb possess anti inflammatori properti inhibit nacht lrr pyd domain contain protein nlrp inflammasom activ dimethyl fumar dmf multipl sclerosi drug activ nuclear factor erythroid relat factor nrf antioxid respons element pathway maintain antioxid status cell present studi design investig role nlrp inflammasom nrfare pathway taa induc hepatotox liver fibrosi ii mechan involv glb dmf mediat hepatoprotect taa induc hepatotox iii additionalsynergist hepatoprotect effect combin treatment nlrp inhibit nrf activ glb dmf mcc oi reverseamelior experiment liver fibrosi complet taa administ intraperiton mice seven consecut week treatment glb dmf glb dmf mcc oi mcc oi provid last three consecut week intervent glb dmf glb dmf mcc oi mcc oi signific protect taa induc oxid stress inflammatori condit improv biochem histolog immunoexpress chang mice glb dmf glb dmf intervent exhibit better protect effect compar mcc oi mcc oi reveal specif inhibitoractiv possess nlrp inflammasom inhibitorynrf activatori properti contrast clinic drug glb dmf sever benefici effect independ nlrp inhibit nrf activ | D058847;D008107 | T033;T116;T047;T123 |
34,664,132 | effect curcumin encapsul pluron f duo speci biofilm streptococcus mutan candida albican assess effect curcumin encapsul pluron f cur plu antimicrobi photodynam therapi apdt duo speci biofilm streptococcus mutan candida albican thermal analysi optic absorpt fluoresc spectroscopi evalu minimum inhibitori concentr mic minimum bactericidalfung concentr obtain biofilm cultur h c treat accord group p l photosensit encapsul pluron f light p l photosensit incorpor dmso light p l pluron f light p l dmso light p l milli q water light p l photosensit encapsul pluron f light p l photosensit dmso light p l pluron f light p l dmso light p l milli q water light negat control group chx chlorhexidin posit control group nys nystatin dark incub min use group receiv apdt irradi blue led nm jcm cell viabil biofilm perform coloni form unit cfuml confoc microscopi two way anova follow tukey post hoc test use signific level p l p l group exhibit better log reduct candida albican streptococcus mutan biofilm p l p l p l experiment group furthermor p l p l show greater reduct candida albican streptococcus mutan apdt mediat cur plu potenti strategi biofilm control duo speci biofilm streptococcus mutan candida albican | D003474;D010778 | T130;T061;T121;T109 |
34,664,131 | multifari effect acc deaminas ep produc pseudomona sp serratia marcescen augment drought stress toler nutrient status wheat drought prime abiot stress rigor influenc plant growth yield qualiti crop current investig illustr bio protect charact serratia marcescen pseudomona sp amelior drought stress toler plant growth nutrient status wheat present studi aim search potenti drought toler plant growth promot rhizobacteria pgpr screen bacteri isol exhibit potenti plant growth promot pgp attribut product acc deaminas exo polysaccharid siderophor ammonia iaa effici solubil zinc phosphat vitro condit assess situ plant growth promot potenti pgpr greenhous experi conduct prime wheat seed screen plant pgpr improv water status reactiv oxygen speci osmolyt accumul chlorophyl carotenoid content plant leav confirm excel drought toler confer abil rrn ii rrc among pgpr rrn ii rrc inocul plant demonstr greater harvest index also exhibit micronutri zinc iron content wheat grain rrn ii rrc identifi rdna sequenc marcescen pseudomona sp respect furthermor amplif acd gene amplifi band size acd gene kb also confirm acc deaminas enzym produc abil pseudomona sp moreov correl coeffici princip compon analysi cluster analysi also demonstr nutrient status valu agronom paramet wheat prime marcescen pseudomona sp par posit control thus outcom compar investig indic pseudomona sp marcescen could util bioinocul wheat sinc improv physiolog status product nutrient status wheat crop drought | D000064;D055864;D000078622;D063245 | T040;T070;T038;T168 |
34,664,130 | midterm outcom strength assess proxim rectus femori refix athlet proxim rectus femori avuls prfa relat rare injuri occur predomin among young soccer player aim studi evalu midterm postop result includ strength potenti via standard strength measur proxim rectus femori tendon refix hypothes major competit athlet return competit rtc refix rectus femori tendon without signific strength function deficit compar contralater side | D052097;D011788 | T023;T078 |
34,664,127 | photodynam control citrus crop diseas citrus econom import fruit crop infecti diseas like citrus canker caus xanthomona citri sub citri citrus varieg chlorosi caus xylella fastidiosa huanglongb associ presenc candidatus liberibact speci anthracnos caus colletotrichum gloeosporioid citrus black spot caus phyllosticta citricarpa impos signific loss control measur involv chemic treatment orchard often erad infect plant unavoid circumv environment impact pesticid socio econom impact erad innov antimicrobi approach like photodynam inactiv test evid suscept xanthomona citri sub citri c gloeosporioid photodynam damag howev realist assess perspect widespread applic photodynam inactiv control citrus diseas necessarili impli microorgan also consid review intend provid critic summari current state research photodynam inactiv citrus pathogen identifi current limit widespread use photodynam treatment citrus crop | D017319 | T039;T121 |
34,664,124 | approach photosynthet product sustain fuel cyanobacteria use tool synthet biolog cyanobacteria photosynthet prokaryot microorgan simpl genet composit prospect photoautotroph cell factori product wide rang biofuel molecul simpl genet composit cyanobacteria allow effortless genet manipul lead increas research endeavor synthet biolog approach various unicellular model cyanobacteri strain like synechocysti sp pcc synechococcus elongatus pcc success engin biofuel generat improv develop synthet biolog tool genet modif method advanc transform techniqu construct strain contain multipl foreign gene singl operon vast expand function use engin photosynthet cyanobacteria generat various biofuel molecul review recent advanc approach synthet biolog tool use cyanobacteri genom edit discuss apart cyanobacteri product various fuel molecul like isopren limonen farnesen squalen alkan butanol fatti acid substitut petroleum fossil fuel futur elabor | D056804 | T109 |
34,664,122 | meta analysi incident intraduct papillari mucin neoplasm extra pancreat malign meta analysi aim quantifi relationship intraduct papillari mucin neoplasm ipmn increas incid extra pancreat malign epm previous report qualit observ cohort studi | D021441;D005770;D010190 | T191 |
34,664,121 | fluoresc angiographi vs direct palpat bowel viabil evalu strangul bowel obstruct surgeri strangul bowel obstruct intestin blood flow ibf usual evalu observ bowel colour peristalsi intestin temperatur arteri pulsat mesenteri investig whether indocyanin green icg fluoresc angiographi icg fa effect altern palpat | D007415;D010535 | T061;T047;T060 |
34,664,120 | optim adapt notif mobil health intervent system reinforc learn data driven behavior simul mobil health mhealth intervent system employ adapt strategi interact user instead design complex strategi manual reinforc learn rl use adapt optim intervent strategi concern user context paper focus issu overwhelm interact learn good adapt strategi user rl base mhealth intervent agent present data driven approach integr psycholog insight knowledg histor data allow rl agent optim strategi deliv context awar notif empir data counterfactu inform user respons receiv notif miss approach also consid constraint frequenc notif reduc interact burden user evalu approach sever simul scenario use real larg scale run data result indic rl agent deliv notif manner realiz higher behavior impact context blind strategi | D017216 | T058 |
34,664,119 | impact global climat chang number replac provis ecosystem servic brazilian cerrado plant essenti predict area loss exchang ecosystem servic adapt communiti impact caus climat chang particular provis ecosystem servic provid econom import plant speci understand associ climat chang impact deforest nativ veget increas accuraci predict thus aim map rich provis ecosystem servic econom import nativ plant ii use forecast present futur distribut ecosystem servic assess area chang number type provis ecosystem servic evalu provis ecosystem servic cerrado nativ speci econom import local popul determin potenti distribut plant use ecolog nich model techniqu group accord differ servic provid forecast variat rich type servic use four futur climat chang scenario rcps servic loss detect model associ variabl repres progress nativ veget deforest biom due agricultur expans current ecosystem servic found simultan practic entir biom howev chang global climat impact potenti geograph distribut plant caus mani area biom reduc avail potenti ecosystem servic moreov due associ exposur climat chang deforest nativ veget northern region biom like distribut ecosystem servic sever affect | D057231;D017753 | T070;T082 |
34,664,116 | prospect sustain wast manag develop countri case studi jordan studi examin key challeng obstruct sustain develop wast manag sector jordan questionnair design convey stakehold collect perspect key challeng wast manag data paramet conclud critic challeng lack strict law legisl ineffici manag insuffici financi capac lack strict law regul lack public awar contribut nonetheless wast manag challeng jordan could cluster three dimens limit privat sector involv weak institut capac poor communiti engag inadequaci wast manag data jordan tackl design simpl innov databank system accord recommend infer questionnair databank system develop way guarante smooth sustain data monitor storag allow user generat daili month annual progress report simpl manner | D003906;D018505 | T080;T068 |
34,664,115 | genipin crosslink chitosanalginatealumina nanocomposit gel bioprint immobil microorgan insid print semi permeabl substrat desir biotechnolog process sinc simplifi product separ purif reduc cost process time end develop strategi synthes feedstock suitabl bioprint mechan rigid insolubl materi embed live bacteria process rout base high particl fill aluminachitosan nanocomposit gel reinforc electrostat interact algin b coval bind chitosan molecul mild gelat agent genipin analyz network format materi properti character rheolog properti printabl feedstock gel stabil measur show genipin crosslink chitosanalginatealumina gel dissolv pbs naoh hcl day incub algin contain gel also show less swell water gel without algin furthermor e coli bacteria embed nanocomposit analyz influenc individu bioink compon well print process bacteri viabil addit algin necessari maintain effect viabil embed bacteria sampl without algin show bacteri viabil experiment result demonstr potenti approach produc macroscop bioactiv materi complex geometri platform novel applic bioprocess | D066330 | T073 |
34,664,113 | chimleish new recombin chimer protein evalu diagnost prognost marker viscer leishmaniasi human immunodefici virus coinfect viscer leishmaniasi vl neglect tropic diseas global import caus parasit genus leishmania coinfect human immunodefici virus hiv common countri diseas endem particular wide use immunolog test vl diagnosi impair sensit se specif sp vlhiv coinfect patient also cross reactiv endem diseas eg chaga diseas malaria tuberculosi develop new antigen improv diagnosi vl vlhiv coinfect predict eight specif b cell epitop four leishmania infantum antigen construct recombin polypeptid chimera antigen call chimleish serolog panel serum sampl use compar diagnost capabl chimleish alongsid individu synthet peptid chimleish react sera vl vlhiv coinfect patient se sp area curv auc peptid show lower reactiv se sp auc l infantum antigen prepar use antigen control se sp auc notabl chimleish demonstr signific reduct p anti chimleish antibodi treatment cure small number patient although limit serolog panel test preliminari data suggest chimleish evalu larger sampl studi diagnosi vl vlhiv coinfect | D060085;D015658;D018314;D007898 | T204;T047 |
34,664,112 | rim lesion demonstr earli relaps remit multipl sclerosi use base suscept weight imag multi institut set rim lesion characteris paramagnet rim suscept base mri suggest reflect chronic inflammatori demyelin multipl sclerosi ms patient assess suscept weight imag swi preval longitudin volum evolut clinic associ rim lesion subject earli relaps remit ms rrms | D009103;D020529 | T047 |
34,664,111 | long term neuroimag follow covid relat leukoencephalopathi year start covid pandem long term neurolog manifest covid increas report long term sequela covid relat leukoencephalopathi howev remain unclear present long term neuroimag follow two case covid relat leukoencephalopathi two case demonstr util brain mri evalu neurolog symptom critic ill patient covid diagnosi under neural injuri prognost futur recoveri presenc leukoencephalopathi may result chronic neurolog manifest may repres poor prognost neurolog recoveri presenc leukoencephalomalacia follow neuroimag potenti indic irrevers white matter damag may associ sever chronic deficit | D000086382;D056784 | T047;T067 |
34,664,110 | clinic util arteri spin label perfus imag emerg depart work stroke like symptom assess util asl evalu patient present ed stroke like symptom | D002545;D000083242;D020521 | T047;T046 |
34,664,107 | potenti benefit implement kaiser permanent neonat earli onset sepsi calcul clinic manag neonat presum sepsi assess potenti benefit implement kaiser permanent earli onset sepsi calcul eo c term antibiot use request laboratori test network neonat intens care unit nicus greec determin incid earli onset sepsi eo greek nicus prospect surveil studi conduct nicus april june data collect newborn week gestat receiv empir antibiot therapi within first day life number live birth posit blood cerebrospin fluid cultur within first day life use calcul eo incid evalu possibl impact implement calcul done compar clinician record manag calcul suggest cours action unit specif incid cultur proven eo rang live birth weight incid rate unit live birth manag eo guid calcul could lead reduct empir antibiot initi group well appear neonat equivoc lower exposur antibiot day per neonat respect laboratori test blood cultur drawn could reduc respect sensit eo c identifi neonat posit blood cultur highconclus manag strategi base kaiser permanent neonat sepsi calcul may signific reduc antibiot exposur invas diagnost procedur hospit late preterm term neonat known neonat frequent expos antibiot presum eo kaiser permanent sepsi calcul reduc antibiot exposur neonat new eo calcul effect antibiot stewardship tool high prescrib countri reduc invas diagnost procedur mother babi separ incid eo greec higher compar european countri | D000071074;D018805 | T047;T046 |
34,664,106 | acut effect two caffein dose bar veloc bench press exercis among women habitu caffein random crossov doubl blind studi involv control placebo condit main goal studi evalu effect two differ dose caffein mgkg enhanc bar veloc bench press women habitu caffein | D002110;D058573 | T039;T121;T109 |
34,664,101 | quantit clinic radiolog recoveri post oper patient superfici siderosi iron chelat superfici siderosi rare neurodegen diseas caus hemosiderin deposit brain surfac although efficaci iron chelat deferipron superfici siderosi recent document compar studi patient underw surgic ablat bleed sourc subsequ receiv treatment without deferipron yet conduct | D002524;D019636;D012806 | T033;T047;T184 |
34,664,099 | chang shoulder extern rotat strength motion lower trapezius transfer infraspinatus children obstetr brachial plexus palsi quantifi chang shoulder extern rotat rang motion strength lower trapezius transfer children obstetr brachial plexus palsi obpp | D001917;D020516;D012785;D064171 | T047;T030;T023;T037 |
34,664,098 | renal epithelioid angiomyolipoma comput tomographi manifest radiolog patholog correl depend differ epithelioid compon percentag renal epithelioid angiomyolipoma eaml rare potenti malign mesenchym lesion main compos epithelioid cell although case report small case seri publish comput tomographi ct manifest radiolog patholog correl depend differ epithelioid compon percentag studi | D018207;D007680 | T191 |
34,664,097 | sciatic foramen anatomi common patholog pictori review articl review relev anatomi imag featur comput tomographi magnet reson imag manag common process involv sciatic foramen anatomi sciatic foramen complex provid import conduit pelvi gluteus lower extrem paper review anatomi common patholog imag featur region includ trauma infect nerv entrap tumor spread hernia vascular anomali | D010388;D012584 | T023 |
34,664,096 | gd eob dtpa enhanc mri noninvas short term assess method liver necroinflamm direct act antivir daa therapi patient chronic hepat c assess liver necroinflamm hcv patient undergon antivir therapi gd eob dtpa enhanc mri histopatholog analys refer | D019698;D008113 | T191;T047 |
34,664,095 | hospit postop opioid use trend neurosurgeri postop opioid use play import role global opioid crisi littl known hospit opioid use trend larg surgic unit investig whether postop hospit opioid consumpt chang larg academ neurosurg unit | D000701;D009493 | T091;T131;T121;T109 |
34,664,094 | invit respons letter editor predictor accept cosmet surgeri instagram imag base activ appear comparison bodi dissatisfact among women respons letter highlight import cosmet surgeon take psychosoci perspect consid role social media influenc accept cosmet surgeri young women furthermor articl provid brief overview possibl intervent use prevent negat influenc social media bodi imag accept procedur aim modifi one bodi pure aesthet reason level evid v journal requir author assign level evid articl full descript evid base medicin rate pleas refer tabl content onlin instruct author wwwspringercom | D000079182;D019651;D013518 | T091;T061;T055 |
34,664,093 | incid surgic site infect triclosan coat monofila versus multifila sutur elect colorect surgeri surgic site infect ssis frequent complic abdomin surgeri use triclosan coat sutur abdomin wall closur report reduc incid ssis howev ssi incid compar use triclosan coat multifila triclosan coat monofila sutur therefor compar incid incision ssis use triclosan coat polyglactin sutur vicryl plus triclosan coat polydioxanon sutur pds plus | D000891;D003107;D014260 | T091;T121;T109 |
34,664,092 | prognost factor children adolesc differenti thyroid carcinoma treat total thyroidectomi rai real life multicentr studi multicentr studi aim investig main prognost factor associ treatment respons year radioact iodin therapi rait last diseas status pediatr patient affect differenti thyroid carcinoma dtc | D000230;D013964 | T191 |
34,664,091 | differenti role residu metabol tumor volum inoper stage iii nsclc chemoradiotherapi immun checkpoint inhibit pet deriv metabol tumor volum mtv independ prognost non small cell lung cancer nsclc patient analyz prognost valu residu mtv rmtv complet chemoradiotherapi crt inoper stage iii nsclc patient without immun checkpoint inhibit ici | D002289;D008175 | T191 |
34,664,089 | incident posterior rib hyperostosi chest ct incid etiolog incident rib hyperostosi defin asymmetr cortic thicken sclerosi medial posterior rib import may lead unnecessari laboratori test addit imag occasion biopsi purpos studi identifi incid rib hyperostosi within differ patient group known increas propens toward osteophyt format ankylosi | D015576;D004057;D054850;D013167 | T047 |
34,664,087 | microbiom iga nephropathi immunopathogen mechan under immunoglobulin nephropathi igan poor understood yet one common caus kidney failur global common referenc syndrom synpharyngit gross hematuria present featur igan led logic associ infect develop igan howev pathogen organ clear link igan advanc sequenc technolog enabl detail character host microbi communiti highlight interrelationship microbiota immun respons health diseas review summar current think relationship microbiota develop igan focus recent studi relat aberr mucos iga bias immun respons microbiota may relat immunopathogenesi igan | D000069196;D005922;D064307 | T007;T047;T001;T032;T028 |
34,664,085 | na activ k channel slack contribut synapt develop plastic human mutat na activ k channel slack kcnt associ epilepsi intellectu disabl accord slack knockout mice slack exhibit cognit flexibl deficit distinct behavior task far howev under caus well role slack hippocampus depend memori function remain enigmat report infant p p slack lack hippocamp ltd ltp like due impair nmda receptor nmdar signal postsynapt glunb level reduc infant slack evidenc lower amplitud nmdar medit excitatori postsynapt potenti low glunb affect nmdar mediat ca influx render cultur hippocamp slack neuron high insensit glunb specif inhibitor ro furthermor dephosphoryl ampa receptor ampar subunit glua involv ampar endocytosi homeostat neuromodul regul plastic reduc chemic ltd cltd infant slack addit detect lack mglur induc ltd infant slack possibl caus upregul recycl endosom associ small gtpase rab might acceler ampar recycl earli endosom interest ltp mglur ltd ltd dephosphoryl cltd restor adult slack togeth normal express level glunb rab hint development restor ltp express despit slack ablat wherea infant adult brain nmdar depend ltd induct depend channel base present find nmdar vesicular transport might repres novel target therapi intellectu disabl associ slack mutat consequ care modul hippocamp slack activ also improv learn abil | D000200;D017774;D009473 | T043;T042 |
34,664,084 | metal accumul ion regul fish hyphessobrycon luetkenii live site chronic contamin copper insight transloc experi fish live joo dia creek southern brazil deal trace metal contamin long term basi aquat environ histor impact copper mine activ order surviv harsh environ local biota develop adapt relat pollut toler aim studi test biochem mechan relat osmoregul among adapt use transloc experi water ionic trace metal composit measur nonmet impact site nmis metal impact site mis creek also whole bodi metal accumul ion concentr branchial enzym activ na k atpas carbon anhydras evalu hyphessobrycon luetkenii nmis mis fish collect immedi store kept cage transloc site result show waterborn cu fold higher mis accord anim contact site show elev whole bodi cu level moreov transloc group show elev na k atpas activ addit fish transloc nmis mis show lower carbon anhydras activ find indic h luetkenii chronic acut expos natur elev waterborn cu show rapid cu bioaccumul unabl readili excret moreov classic cu osmoregulatori toxic relat na k atpas inhibit observ convers impact ammonia excret relat carbon anhydras inhibit may occur | D003300;D014874 | T131;T121;T196;T123 |
34,664,083 | year old patient polymorph prematur ventricular contract year old patient prematur ventricular contract normal left ventricular function refer reablat unsuccess cathet ablat attempt holter monitor demonstr high burden prematur ventricular contract present throughout whole record patient report occasion paralyt attack face dysmorph appear wide distanc eye caudal insert ear high forehead three featur result clinic diagnosi confirm molecular biolog complet chang therapeut strategi | D050030;D017115;D017180;D018879 | T047;T061;T046 |
34,664,081 | volatil anesthet prehospit analgesia paramed overview treatment acut pain central task emerg medicin yet prehospit pain relief often insuffici delay sinc administr potent intraven analges drug opioid most limit physician due legal restrict train defici germani austria frequent prehospit oper emerg physician demand later anguish patient limit dispos physician patient potenti life threaten condit thus inhal analges could repres interest alternativea mixtur nitrous oxid oxygen n livopan avail germani austria sever year howev prehospit use livopan mere realiz one trial publish addit methoxyfluran penthrop volatil anesthet group dialkyl ester dichloro difluoroethyl methyl ester approv treatment moder sever pain follow trauma adult mani european countri recent year brought onto market austria sever hospit trial demonstr high effect settingthi articl discuss effect prehospit area applic substanc light exist literatur provid narrat overview current studi situat report recent perform prehospit applic studi methoxyfluran penthrop austriath need pressur gas cylind use n repres certain limit prehospit use furthermor certain injuri inner ear pneumothorax n use risk diffus hypoxemia address user particular care limit use alcohol addict vegan advanc n odorless fast onset action usabl patient month old stabil effect circul plenti literatur regard prehospit well hospit use nitrous oxid emerg obstetr pediatr set show effect singl drug well combin analges paracetamol various opioid long tradit anglo american countri also base safeti low rate side effectsmethoxyfluran easier store handl may slight effect sever pain trauma howev approv restrict adult work signific better increas age base declin minim alveolar concentr mac inhal anesthet increas age furthermor decad use inhal methoxyfluran australia shown drug effect safe low side effect broad spectrum applic use methoxyfluran limit patient sever hepat renal insuffici characterist odor describ unpleas patient europ three larg hospit trial show strong pain relief trauma patient even compar opioidsoveral base current evid use nitrous oxid even methoxyfluran may recommend also prehospit use skill paramed | D059787;D000777;D004632 | T121;T184;T039;T093;T061;T058 |
34,664,079 | preval sever hand eczema dutch general popul cross section questionnair studi within lifelin cohort studi data chronic hand eczema sever hand eczema general popul scarc cross section studi questionnair sent lifelin cohort studi particip order investig preval sever hand eczema dutch general popul total subject includ lifetim preval hand eczema confid interv year preval confid interv self report physician diagnos preval confid interv year preval chronic hand eczema confid interv major subject hand eczema almost clear worst ever preval sever sever hand eczema worst ever general popul confid interv futur epidemiolog studi general popul includ data chronic hand eczema sever hand eczema provid perspect burden hand eczema | D004485;D006229 | T047 |
34,664,078 | patch test propoli differ geograph origin baselin seri chemic composit propoli vari geograph origin howev known whether affect frequenc contact allergi propoli order studi frequenc contact allergi propoli differ geograph origin concomit reaction consecut patient dermat denmark lithuania spain patch test propoli china lithuania north america sweden baselin seri patch test reaction type propoli rang statist signific differ frequenc posit reaction type propoli respect countri test singl commerci avail type propoli detect approxim half propoli allerg patient patient allerg propoli concomit reaction myroxylon pereira resin colophonium fragranc mix common rang | D017449;D010476;D011429 | T047;T121;T073;T123 |
34,664,076 | iron status moder late preterm infant prospect cohort studi guidelin micronutri supplement moder late preterm infant mlp most extrapol smaller preterm larg due lack systemat studi physiolog status special group infant actual practic vari wide prospect studi iron status measur serum ferritin sf haematolog indic month correct age infant born week gestat mlp receiv mgkgday oral iron week postnat age proport mlp normal iron status iron replet ie neither iron defici id iron excess measur id anaemia growth develop risk factor id also analys infant studi babi late preterm seventi four iron replet defici excess month high variabl sf level minimum maximum gl median iqr gl note entir cohort also within iron defici median iqr gl differ haematolog indic id infant compar normal iron status inspit oral iron supplement reason complianc mlp iron defici month correct age high variabl note sf level could justifi need monitor iron status group preterm infant could quintessenti aid individu iron supplement advic | D018798;D007501 | T047;T121;T196;T123 |
34,664,075 | locus specif express analysi transpos element transpos element tes associ mani frequent detriment biolog role consequ regul tes eg via dna methyl histon modif consid critic maintain genom integr function still high throughput studi tes usual limit famili consensus sequenc level align problem prompt high sequenc similar short read length entir comprehend effect reason te express howev necessari assess te express level individu instanc simul studi demonstr sequenc similar short read length rule accur assess differenti express tes instanc level slight modif exist method te express analysi work surpris well convent pair end sequenc data find salmont telescop accur talli consider amount te instanc allow differenti express recoveri model non model organ | D004251;D023281 | T091;T086;T114;T123 |
34,664,074 | maresnet predict transcript factor bind site combin multi scale bottom top attent residu network accur identif transcript factor bind site great signific understand gene express biolog develop drug design although varieti method base deep learn model larg scale data develop predict transcript factor bind site dna sequenc room improv predict perform addit effect interpret deep learn model great desir present maresnet new deep learn method predict transcript factor bind site chip seq dataset specif maresnet combin bottom top attent mechan state art feed forward network resnet construct stack attent modul generat attent awar featur particular multi scale attent mechan util first stage extract rich repres sequenc featur discuss attent awar featur learn differ attent modul accord chang layer go deeper featur learn maresnet also visual tmap tool illustr method extract uniqu characterist transcript factor bind site perform maresnet extens test test subset averag auc higher current state art method overal studi provid new use framework predict transcript factor bind site combin funnel attent modul residu network | D000077321 | T066 |
34,664,072 | identifi impact air pollut subacut asthma symptom use digit medic sensor object track asthma medic use exposur real time space feasibl previous exposur assess typic tie residenti locat ignor exposur within pattern daili activ | D000393;D000397;D001249;D004781 | T047;T131;T037;T080;T069 |
34,664,071 | male femal differ acut thorac aortic dissect systemat review meta analysi studi aim systemat review publish literatur male femal differ present manag outcom patient diagnos acut thorac aortic dissect ad | D000784;D017545;D019917;D057510 | T047;T061;T046 |
34,664,058 | groov preauricular area human ilium indic sex trace parturit histor background test novotn method paper summar histori studi bone surfac depress near contact surfac sacroiliac joint groov locat linea terminali known literatur scar parturit pelvic scar sinc begin th centuri sulcus praeauriculari confus sulcus paraglenoidali without satisfactori explan aetiolog groov preauricular area pelvic bone refer indic femal sex use sex estim way respect natur sex differ novotn includ bone structur describ various author femal male method holist evalu propos three step categor evalu bone surfac pelvic preauricular area three sub characterist score independ order distinguish sulcus praeauriculari femal trait structur may occur sex howev novotn work becom wide known test novotn method perform four group individu known sex without knowledg reproduct histori femal novotn bruzek mikeov includ total pelvic bone male femal result show femal morpholog character presenc various form sulcus praeauriculari occur total femal femal morpholog found male male morpholog observ male also femal indetermin ambigu morpholog found male femal applic novotn method show total specimen femal morpholog femal male therefor appropri use reliabl method estim sex skelet sampl test relationship morpholog obstetr histori femal necessari use sampl known pariti | D007085;D010384 | T023;T029 |
34,664,057 | accessori sacroiliac joint iliosacr complex two case studi mediev post mediev cemeteri northern itali detect parturit marker archaeolog pelvic bone relev reconstruct biolog profil femal individu whose life histori pregnanc repres crucial biolog event preliminari studi sampl individu mediev post mediev cemeteri san biagio cittiglio northern itali two skeleton exhibit evid noteworthi boni project sacroiliac level clinic studi occurr connect sever biolog variabl age obes multipl birth suggest possibl consequ weight bear stress address two case accessori sacroiliac joint iliosacr complex found two femal individu studi part anthropolog analysi sampl cemeteri cittiglio individu investig date particular examin femal male pelv order highlight express aspect pelvic featur sex | D055699;D010384 | T023;T083 |
34,664,056 | obstetr adapt human pelvic inlet base sampl femal male match bodi size comparison three speci primat sexual monomorph bodi size human male larger femal bodi size femal larger male pelvic size percentag pelvic sexual size dimorph sex larger meansex lower mean use infer select obstetr adapt pelvic size associ bodi size interpret percentag sexual size dimorph necessit control bodi size studi use larger sampl femal male identifi subsampl femal male match femor length femor head diamet clavicular length femal male five measur pelvic inlet human sampl control bodi size compar three primat speci sexual monomorph bodi size give birth newborn higher relat bodi mass human aotus azara femal male hylob lar femal male saguinus geoffroyi femal male result show human highest percentag sexual size dimorph pelvic inlet circumfer azara h lar geoffroyi human higher sexual size dimorph inlet circumfer despit lower relat newborn bodi mass compar speci human newborn larger bodi mass predict anthropoid adult femal bodi mass human birth bigger babi predict bodi mass increas select pressur femal enlarg pelvic inlet | D010384 | T023 |
34,664,055 | age depend chang pelvic shape adulthood human pelvi report chang shape throughout adult lifetim also express parturit scar pelvic featur increas age howev littl known caus time chang investig chang pelvic shape express pelvic featur appli comprehens geometr morphometr approach modern sampl adult individu known age pariti caus death result confirm pelvi chang shape adult life larger magnitud femal compar male moreov femal show three differ phase pelvic shape chang coincid main period reproduct year period menopaus postmenopaus period year age male exhibit two phase relat similar shape chang express parturit scar increas femal year age stay relat constant thereaft weak increas featur express found male hypothes chang adult pelvic shape featur express result combin hormon mediat mechan induc bone remodel estrogen induc pregnanc relat bone remodel domin premenopaus women wherea bone remodel respons mechan factor may underli pelvic shape chang men postmenopaus women continu widen birth canal reproduct period eas childbirth popul unlik remodel pattern specif evolv obstetr adapt human lineag high conserv endocrin system estrogen induc pelvic bone remodel alreadi place neonat brain increas human lineag regular control conserv pathway may fine tune select forc human lineag | D010384 | T023 |
34,664,054 | anatom basic technic approach sacral preauricular extens preauricular sulci dorsal pubic pit modern anatom specimen aim studi evalu three select osseous pelvic featur modern anatom specimen sacral preauricular extens preauricular sulcus pit dorsal side pubic bone later symphysi specif signific featur debat genesi larg unclear descript data specif soft tissu structur surround anterior sacroiliac joint gap pubic symphysi generat assess fresh pelv embalm hemipelv human bodi donor comput tomographi ct perform specimen three dimension surfac model generat analys afterward specimen underw anatom dissect final macer dissect becam appar anterior sacroiliac ligament due posit shape potenti impact sacroiliac joint adjac osseous structur requir detail analysi dimens promis result term sacral preauricular extens measur triangular part anterior sacroiliac ligament signific longer femal male pelvic floor muscl fibr fascial part direct connect ligament specimen import start point larger depth studi evalu anatom structur connect dorsal pit refut assumpt pelvic floor muscl fascia could exert influenc format histolog evalu ligament pubic symphysi especi dorsal pubic ligament would expedi clarifi etiolog featur | D011630;D011631 | T023;T030 |
34,664,053 | bioarchaeolog reconstruct popul santa cristina caio siena itali th th centuri ce present research analyz human skelet remain santa cristina caio siena itali aim reconstruct demographi musculoskelet stress marker earli mediev italian popul cemeteri area recov excav campaign carri univers siena unearth individu date back th th centuri ce analyz sampl count individu juvenil adult sex ratio f reveal slight higher percentag femal sex reach old age probabl experienc similar life condit support archaeolog data tend exclud exist class structur within societi femal show higher mortal young adult age class year probabl consequ short term pregnanc childbirth post cranial indic musculoskelet stress marker reveal strength physic constitut highlight statist signific differ degre biomechan load two sex subject goal present research present composit earli mediev popul central itali could repres import tile understand dynam complex histor period | D001106;D000071298 | T091;T023;T090 |
34,664,052 | process fast gell hydrogel precursor microfluid electrocoalesc reactiv speci microscop hydrogel also refer microgel find broad applic life materi scienc well establish techniqu fabric uniform microgel droplet microfluid optim mix hydrogel precursor compon crucial yield homogen microgel respect morpholog mechan distribut function moieti howev process premix polym precursor high reactiv fast even instantan gelat insid fluid reservoir microchannel flow cell common occur lead increas fluid viscos time thus exacerb intrins control fluid flow rate droplet microgel uniform key sell point microfluid materi design address challeng util microflow cell integr electrod enabl fast addit mix hydrogel precursor demand mean emuls droplet coalesc two popul surfact stabil aqueous droplet first contain materi basi microgel second contain anoth gel form compon eg crosslink form two consecut microchannel junction merg via temporari thin film instabl approach provid abil process hydrogel system otherwis challeng process uniform droplet microgel convent droplet microfluid demonstr versatil fabric microgel uniform shape composit use fast hydrogel via thiol michael addit reaction non coval self assembl furthermor elucid limit electrocoalesc reactiv hydrogel precursor process sodium algin crosslink calcium induc ionic interact instantan type hydrogel electrocoalesc algin calcium ion result format morpholog isotrop microgel instead enabl creation anisotrop microgel morpholog tunabl shape previous achiev select crosslink elabor higher order emuls aqueous two phase system microgel templat | D020100;D000080386 | T122 |
34,664,051 | quantit map interact egfr cell membran peptid probe human epiderm growth factor receptor member epiderm growth factor receptor famili involv various biolog process cell prolifer surviv differenti migrat invas general function form homo hetero dimer oligom famili member although essenti role cellular activ wide recogn question concern spatial distribut membran interact erbb famili member remain obscur obtain high qualiti dstorm imag nanoscal cluster recogn peptid probe found form cluster contain differ number molecul cell membran moreov found egfr form hetero oligom non stimul cell membran wherea egf stimul reduc degre heteromer suggest egfr hetero oligom may inhibit activ egfr collect work reveal cluster distribut quantifi chang interact egfr rest activ state singl molecular level promot deeper understand protein protein interact cell membran | D010455;D018719 | T192;T116;T121;T126 |
34,664,044 | flexibl base modul dna nanostar phase separ phase separ biomolecul play key role physiolog compartment well patholog aggreg deeper understand biomolecular phase separ requir dissect relat intermolecular interact result phase behavior dna nanostar multival dna assembl sticki end defin attract interact repres ideal system probe fundament relat govern phase separ process use dna nanostar systemat studi structur flexibl exhibit interact speci impact phase behavior design multipl nanostar vari degre flexibl use singl strand gap differ length arm nanostar unit find structur flexibl drastic alter phase diagram dna nanostar way phase separ flexibl structur strong inhibit result due self inhibit loss valenc rather ascrib generic flexibl driven chang thermodynam system work provid potenti regulatori mechan cell may exploit dynam control intracellular phase separ also rout build synthet system assembl control signal depend manner | D004247 | T114;T123 |
34,664,026 | household cluster sever acut respiratori syndrom coronavirus sar cov infect suzhou china sever acut respiratori syndrom coronavirus sar cov emerg virus caus substanti morbid mortal worldwid perform cross section investig sar cov cluster suzhou determin transmiss virus among close contact assess demograph clinic characterist index secondari case | D016358;D005191;D000086402 | T079;T098;T099;T005;T058;T062;T102 |
34,663,995 | emerg depart manag sever acut psychomotor agit rare case adult present rasmussen syndrom report sever acut psychomotor agit treat emerg depart hypothes rare case adult present rasmussen syndrom | D004660;D011595 | T033;T047;T184 |
34,663,994 | second generat antipsychot cardio metabol event real world analysi healthcar cost analysi identifi character new user second generat antipsychot sga itali assess occurr cardio metabol cm event year sga start therapi annual healthcar cost perspect italian nation health system inh | D014150 | T039;T121 |
34,663,993 | lifestyl patient sever mental disord new target psychosoci intervent patient sever mental disord name schizophrenia major depress bipolar disord reduc life expect least year compar general popul mortal gap due higher preval comorbid physic disord diabet hypertens cardiovascular diseas patient compar general popul factor contribut mortal gap includ lack access primari care servic sever clinic symptom intern stigma discrimin healthcar profession pharmacolog treatment unhealthi lifestyl behaviour sever intern studi highlight high preval unhealthi lifestyl behaviour patient sever mental disord data avail italian real world set | D001714;D001523;D012559 | T048 |
34,663,992 | invis pain women sexual coercion psycholog distress somat symptom sexual coercion among marri women wide conceal serious public health concern may imped physic sexual psycholog health women | D000071896;D000079225 | T048;T184 |
34,663,991 | assess premenstru symptom valid italian version premenstru symptom screen tool aim studi provid italian valid premenstru symptom screen tool psst psst retrospect questionnair origin develop english languag use screen premenstru syndrom pms premenstru dysphor disord pmdd pmdd pms common often adequ recogn treat although heavili interfer women qualiti life | D007802;D011788 | T171;T078 |
34,663,990 | inflammatori marker perinat depress women without histori trauma increas inflamm describ consist associ depress moreov pro inflammatori pattern found women histori trauma irrespect major depress diagnosi studi explor possibl associ inflammatori marker perinat depress pnd measur serum level cytokin il tnf ifn acut phase protein crp erythrocyt sediment rate esr cortisol brain deriv neurotroph factor bdnf women second trimest pregnanc moreov test whether biolog marker correl sever pnd trauma histori resili level | D019052;D003865 | T048 |
34,663,989 | mother babi bond systemat review perinat depress child development disord perinat depress common mental disord becom signific public health concern especi western develop countri preval mental ill concern affect mother also child famili | D003863;D009035 | T092;T048;T184;T099 |
34,663,979 | circadian clock guid dendrit cell skin lymphat migrat leukocyt skin lymph node lns via affer lymphat vessel lvs pivot adapt immun respons circadian rhythm emerg import regul leukocyt traffick lns via blood demonstr dendrit cell dcs circadian migrat pattern lvs peak rest phase mice migrat pattern determin rhythmic gradient express chemokin ccl adhes molecul mice human chronopharmacolog target involv factor abrog circadian migrat dcs identifi cell intrins circadian oscil skin lymphat endotheli cell lec dcs cogovern rhythm genet disrupt either cell type ablat circadian traffick observ indic circadian clock control infiltr dcs skin lymphat process essenti mani adapt immun respons relev vaccin immunotherapi | D056704;D002633;D057906 | T040;T039;T038;T043 |
34,663,978 | transmiss train immun heterolog resist infect across generat intergener inherit immun trait link epigenet modif demonstr plant invertebr provid evid transmiss train immun across generat murin progeni surviv subleth system infect candida albican zymosan challeng progeni train mice exhibit cellular development transcript epigenet chang associ bone marrow resid myeloid effector progenitor cell compart moreov progeni train mice show enhanc respons endotoxin challeng alongsid improv protect system heterolog escherichia coli listeria monocytogen infect sperm dna parent male mice intraven infect fungus c albican show dna methyl differ link immun gene loci result provid evid inherit train immun mammal enhanc protect infect | D040941 | T044 |
34,663,975 | ip gpcr messeng mediat neural control synaptotagmin depend insulin exocytosi glucos homeostasi diphosphoinositol pentakisphosph ip signal metabolit link various cellular process extracellular stimuli elicit ip signal remain unclear show ip cell mediat parasympathet stimul synaptotagmin syt depend insulin releas mechanist vagal stimul activ muscarin acetylcholin receptor trigger g q plc pkc pkd depend signal activ ipk ip synthas wherea ip precursor ip compet pip bind syt ca select bind ip high affin free syt enabl fusion insulin contain vesicl cell membran cell specif ipk delet diminish insulin secret glucos clearanc elicit muscarin stimul wherea mice carri phosphoryl mimick hyperact ipk mutant display augment insulin releas congenit hyperinsulinaemia obes phenotyp absent mice lack syt studi propos new conceptu framework inositol pyrophosph physiolog ip act gpcr second messeng interfac peripher nervous system metabol organ transmit g q coupl gpcr stimul unclamp syt depend perhap exocytot event | D005089 | T043 |
34,663,973 | fast drive metabol molecular geroprotect effect calori restrict diet mice calori restrict cr promot healthi age divers speci recent shown fast portion day metabol benefit promot lifespan find complic interpret rodent cr studi anim typic eat per day rapid consum food collater impos fast show prolong fast necessari key metabol molecular geroprotect effect cr diet use seri feed regimen dissect effect calori fast proceed demonstr fast alon recapitul mani physiolog molecular effect cr result shed new light much eat regul metabol health longev demonstr daili prolong fast sole reduc calor intak like respons metabol geroprotect benefit cr diet | D031204 | T033;T061 |
34,663,964 | control satellit cell function muscl regener disrupt age skelet muscl contain design popul adult stem cell call satellit cell general quiescent homeostasi satellit cell prolifer sporad usual asymmetr cell divis replac myofibr damag daili activ maintain stem cell pool howev satellit cell also robust activ upon tissu injuri undergo symmetr divis generat new stem cell numer prolifer myoblast later differenti muscl cell myocyt rebuild muscl fibr therebi support skelet muscl regener recent discoveri show satellit cell great degre popul heterogen cell fate choic regener process dictat intrins extrins mechan extrins cue come larg communic numer distinct stromal cell type nich creat dynam interact microenviron review discuss role regul satellit cell skelet muscl homeostasi regener particular highlight cell intrins control quiescenc versus activ import satellit cell nich communic deregul mechan associ age increas understand satellit cell regul help advanc muscl regener rejuven therapi | D032496 | T025 |
34,663,963 | dual detect chromatin access dna methyl use atac epigenom multidimension individu molecular compon oper differ level control transcript output techniqu combin measur featur reveal precis correspond genom space tempor connect better understand joint regul gene atac integr method probe dna methyl chromatin access singl dna fragment librari intact nuclei undergo tn transposit isol dna fragment within nucleosom free region isol fragment expos sodium bisulfit librari amplif sequenc typic atac experi detect peak region p cover million cpg site least coverag site display rang methyl valu depend cellular genom context approach well suit time cours studi aim captur chromatin dna methyl dynam tandem cellular differenti protocol complet standard molecular biolog equip expertis analysi result data use public avail softwar requir basic bioinformat skill interpret result | D001681;D019175;D044127 | T044;T059;T045 |
34,663,962 | control polar human gastrointestin organoid investig epitheli biolog infecti diseas human epitheli organoid spheroid deriv adult tissu stem cell enabl investig epitheli physiolog diseas host interact microorgan virus bioactiv molecul one challeng use organoid difficulti access apic lumin surfac epithelium enclos within organoid interior protocol describ method previous develop control human mous organoid polar suspens cultur apic surfac face outward medium apic organoid protocol establish apic polar rapid h preserv epitheli integr maintain secretori absorpt function allow regul differenti provid detail descript organoid polar revers method compat character assay exampl applic technolog specif impact host microb interact epitheli function control organoid polar expand possibl organoid use gastrointestin respiratori health diseas research | D002454;D041981;D009940 | T043;T022;T024 |
34,663,959 | decod molecular cellular heterogen mous nucleus accumben nucleus accumben nac play import role regul multipl behavior dysfunct link mani neural disord howev molecular cellular anatom heterogen under function divers remain incomplet understood studi generat cell census mous nac use singl cell rna sequenc multiplex error robust fluoresc situ hybrid reveal high level cell heterogen brain region show transcript spatial divers neuron subtyp underli nac anatom function heterogen find explain seem simpl neuron composit nac achiev high heterogen structur divers function collect studi generat spatial resolv cell taxonomi understand structur function nac demonstr import combin molecular spatial inform reveal fundament featur nervous system | D009474;D009714 | T025;T023 |
34,663,955 | time nanoneuro studi electron properti materi nanoscal unveil physic law generat materi nanoparticl quantum dot nanodiamond nanoelectrod nanoprob independ larg scale public privat neurosci program launch develop method measur manipul neural circuit live anim human review upcom field nanoneuro defin intersect nanosci neurosci aim develop nanoscal method record stimul neuron activ uniqu physic properti nanomateri intrins advantag biosensor actuat may applic human without need genet modif thus nanosci could make major methodolog contribut futur neurosci general biomed scienc | D009488;D045663 | T091;T073 |
34,663,953 | microtubul tune mechanosensit cell respons mechanotransduct process cell sens mechan properti surround environ adapt accord perform cellular function adhes migrat differenti integrin mediat focal adhes major site mechanotransduct connect actomyosin network crucial mechanosens well generat transmiss forc onto substrat despit emerg major regul cell adhes migrat contribut microtubul mechanotransduct still remain elus show talin actomyosin depend mechanosens substrat rigid control microtubul acetyl tubulin post translat modif promot recruit tubulin acetyltransferas tat focal adhes microtubul acetyl tune mechanosensit focal adhes yes associ protein yap transloc microtubul acetyl turn promot releas guanin nucleotid exchang factor gef h microtubul activ rhoa actomyosin contractil traction forc result reveal fundament crosstalk microtubul actin mechanotransduct contribut mechanosensit cell adhes migrat | D040542;D008870 | T044;T026 |
34,663,944 | har multimod data integr advanc precis oncolog advanc quantit biomark develop acceler new form data driven insight patient cancer howev approach limit singl mode data leav integr approach across modal relat underdevelop multimod integr advanc molecular diagnost radiolog histolog imag codifi clinic data present opportun advanc precis oncolog beyond genom standard molecular techniqu howev medic dataset still spars use train modern machin learn techniqu signific challeng remain remedi combin effort data engin comput method analysi heterogen data instanti synergist data model biomed research requir success perspect offer opinion synthes complementari modal data emerg multimod artifici intellig method advanc along direct result reimagin class multimod biomark propel field precis oncolog come decad | D009369 | T191 |
34,663,943 | manipul apoptosi cancer therapi use bh mimet drug apoptosi form program cell death regul balanc prosurviv proapoptot bcl protein famili member evas apoptosi hallmark cancer aris balanc tip favour surviv one form anticanc therapeut term bh mimet drug develop direct activ apoptosi machineri malign cell drug bind inhibit specif prosurviv bcl famili protein therebi mimick interact bh domain proapoptot bcl famili protein bcl specif inhibitor venetoclax approv us food drug administr mani regulatori author worldwid treatment chronic lymphocyt leukaemia acut myeloid leukaemia bh mimet drug target bcl prosurviv protein test preclin model cancer drug target mcl bcl x l advanc phase clinic trial certain cancer therapeut efficaci toler need care balanc achiev therapeut window wherebi signific anticanc activ accept safeti profil review outlin current state bh mimet drug target various prosurviv bcl famili protein discuss emerg data regard primari acquir resist agent approach may overcom highlight issu need address advanc clinic applic bh mimet drug alon combin addit anticanc agent exampl standard chemotherapeut drug inhibitor oncogen kinas improv respons patient cancer | D000970;D015451 | T191;T121;T109 |
34,663,941 | hepatocyt organoid cell transplant futur hold histor primari hepatocyt difficult expand maintain vitro review focus recent advanc establish hepatocyt organoid potenti applic regen medicin first provid background renew hepatocyt homeostat well injur liver next describ strategi establish primari hepatocyt organoid deriv either adult fetal liver base insight signal pathway regul hepatocyt renew vivo characterist organoid describ herein notabl hepatocyt organoid adopt either prolif metabol state depend cultur condit furthermor metabol gene express profil modul base principl govern liver zonat final discuss suitabl cell replac therapi treat differ type liver diseas current state cell transplant vitro expand hepatocyt mous model addit provid insight regen microenviron injur host liver may facilit donor hepatocyt repopul summari transplant vitro expand hepatocyt hold great potenti larg scale clinic applic treat liver diseas | D008107;D009940 | T033;T047;T024 |
34,663,940 | dissect singl cell genom clonal organoid techniqu revolut genom sequenc technolog enabl comprehens detect genom variat human cell includ inherit germlin polymorph de novo mutat postzygot mutat technolog combin techniqu isol expand singl cell dna landscap somat mosaic individu bodi systemat reveal singl cell resolut summar three strategi whole genom amplif microdissect clonal patch tissu vitro clonal expans singl cell current appli singl cell mutat analys among approach vitro clonal expans particular via adult stem cell deriv organoid cultur technolog yield sensit precis catalog somat mutat singl cell moreov produc live mutant cell downstream valid experi multiom profil possibl synergist combin organoid cultur genom sequenc research track genom chang singl cell resolut lead new discoveri previous imposs | D016678;D009940 | T024;T028 |
34,663,939 | gastrointestin cancer organoid applic basic translat cancer research cancer major health problem lead caus death worldwid earli cancer detect continu chang treatment strategi improv overal patient surviv recent develop target drug offer new opportun person cancer treatment nevertheless individu treatment accompani need biomark predict respons patient certain drug one promis breakthrough recent year might help overcom problem organoid technolog organoid cultur exhibit self renew capac self organ long term prolifer recapitul mani aspect primari tissu generat patient deriv organoid pdo librari constitut live biobank allow depth analysi tissu function develop tumor initi cancer pathobiolog organoid deriv gastrointestin tissu includ esophag gastric liver pancreat small intestin colorect tissu cancer tissu pdos amen various techniqu includ sequenc analys drug screen target therapi test tumor microenviron studi genet engin capabl review discuss differ applic gastrointestin organoid basic cancer biolog clinic translat | D005770;D009940 | T191;T024 |
34,663,938 | organoid imag base phenotyp chemic screen imag base phenotyp screen reli extract multivari inform cell cultur larg varieti condit technic advanc high throughput microscopi enabl screen increas complex biolog relev model system end organoid hold great potenti high content screen recapitul mani aspect parent tissu deriv patient materi howev screen substanti difficult organoid classic cell line technic analyt standpoint review present overview studi employ organoid screen applic discuss promis challeng small molecul treatment organoid give practic advic design run analyz high content organoid base phenotyp screen | D009940 | T024 |
34,663,937 | strategi genet manipul adult stem cell deriv organoid organoid technolog allow expans primari epitheli cell normal diseas tissu provid uniqu model human patho biolog three dimension environ adult stem cell self organ differenti gain tissu specif featur access genet manipul enabl investig molecular mechan under cell fate regul cell differenti cell interact recent year power methodolog use lentivir transgenesi crisprca gene edit singl cell readout develop studi gene function carri genet screen organoid howev multicellular dynam natur stem cell deriv organoid also present challeng genet experiment review focus adult gastrointestin organoid summar state art protocol success transgenesi provid outlook emerg genet techniqu could increas applic organoid enhanc potenti organoid base techniqu deepen understand gene function tissu biolog | D053687;D009940 | T025;T024 |
34,663,936 | organoid host model infect biolog review method infecti diseas major threat worldwid alarm rise antimicrobi resist emerg new potenti pathogen better understand infect process urgent need last centuri develop vitro vivo model led remark contribut current knowledg field infect biolog howev appli recent advanc organoid cultur technolog research infecti diseas take field higher level complex describ current method avail studi infecti diseas use organoid cultur | D001695;D009940 | T091;T024 |
34,663,935 | biobank human gut organoid translat research develop human organoid cultur model led unpreced opportun generat self organ three dimension miniatur organ close mimic vivo condit abil expand cultur bank organoid provid research opportun generat next generat live biobank substanti contribut translat research wide rang area includ drug discoveri test regen medicin well develop person treatment approach howev compar tradit tissu repositori generat live organoid biobank requir much higher level coordin addit resourc scientif expertis short review discuss opportun challeng associ generat live organoid biobank focus human intestin organoid highlight key aspect need consid provid outlook futur develop excit field | D009940;D057170 | T062;T024 |
34,663,928 | combin system local appli cellular therapi treatment system sclerosi system sclerosi ssc complex autoimmun diseas character function structur alter microvascular network associ cutan viscer fibrosi lesion convent therapi base use immunomodulatori molecul symptomat manag often prove insuffici particular patient suffer sever rapid progress form diseas context cellular therapi approach could repres credibl solut goal act differ compon diseas immun system vascular system extracellular matrix purpos review provid overview cellular therapi avail manag ssc first part focus system inject therapi whose primari effect base immunomodulatori properti immun system reset includ autolog hematopoiet stem cell transplant intraven inject mesenchym stem cell second part discuss local administ regen cell therapi main deriv adipos tissu develop manag local complic hand face disabl | D045164;D059630;D012595 | T025;T047;T061 |
34,663,927 | connect mhc bind motif hla allel via deep learn select peptid present mhc molecul crucial antigen discoveri previous sever predictor shown impress perform bind affin howev decis mhc residu relat select bind peptid still unrev connect hla allel bind motif via deep learn base framework mhcfovea mhcfovea expand knowledg mhc bind motif allel cluster n termin c termin sub motif observ unobserv allel mhcfovea calcul hyper motif correspond allel signatur import posit disclos relat bind motif mhc sequenc mhcfovea deliv pair hyper motif allel signatur hla hla b hla c pair hyper motif allel signatur disclos critic polymorph residu determin bind prefer believ valuabl antigen discoveri vaccin design allel specif concern | D000483;D000077321 | T066;T028 |
34,663,923 | mutat signatur esophag squamous cell carcinoma eight countri vari incid esophag squamous cell carcinoma escc show remark variat incid fulli explain known lifestyl environment risk factor specul unknown exogen exposur could respons combin field mutat signatur analysi cancer epidemiolog studi escc genom eight countri vari incid rate mutat profil similar across countri studi associ specif mutat signatur escc risk factor identifi tobacco alcohol opium germlin variant modest impact mutat burden find evid mutat signatur indic exogen exposur capabl explain differ escc incid apolipoprotein b mrna edit enzym catalyt polypeptid like apobec associ mutat signatur singl base substitut sbs sbs present case respect account mutat burden averag indic apobec activ crucial step escc tumor develop | D009154 | T045 |
34,663,921 | unannot protein expand mhc restrict immunopeptidom cancer tumor associ epitop present mhc activ immun system cancer cell typic identifi annot protein code region genom whether peptid origin novel unannot open read frame nuorf contribut antitumor immun respons remain unclear show peptid origin nuorf detect ribosom profil malign healthi sampl display mhc cancer cell act addit sourc cancer antigen construct high confid databas translat nuorf across tissu nuorfdb use detect translat nuorf mhc immunopeptidom mass spectrometri analysi includ peptid result somat mutat nuorf cancer sampl well tumor specif nuorf translat melanoma chronic lymphocyt leukemia glioblastoma nuorf unexplor pool mhc present tumor specif peptid potenti immunotherapi target | D007167;D008545 | T191;T061 |
34,663,920 | high throughput function character protein phosphoryl site yeast phosphoryl critic post translat modif involv regul almost cellular process howev fewer thousand recent discov phosphosit function annot studi devis chemic genet approach studi function relev phosphosit saccharomyc cerevisia generat yeast strain mutat specif phosphosit screen fit condit along gene delet librari phosphosit exhibit growth phenotyp suggest like function infer function base similar growth profil gene delet valid subset thermal proteom profil lipidom high fraction exhibit phenotyp seen correspond gene delet suggest gain function effect phosphosit conserv human sever yeast phenotyp indic human function relev high throughput approach allow function character individu phosphosit scale | D012441;D029701 | T004;T116 |
34,663,917 | addit genet variat pinus radiata bark chemistri chemic trait associ variat mammalian bark strip secondari metabolit suggest major mechan explain genet variat herbivori level pinus radiata potenti incorpor chemic trait breedingdeploy programm part depend presenc addit genet variat relev chemic trait studi near infrar spectroscopi use quantifi constitut induc level compound bark tree p radiata full sib famili tree sampl chemistri protect brows induc level obtain subject half tree artifici bark strip treatment effect bark chemistri assess along narrow sens herit signific non addit genet effect addit genet correl compound bark strip mammalian herbivor observ unprotect replic field trial result indic signific addit genet variat low moder narrow sens herit estim compound ii signific induc effect detect chemic signific genet variat induc detect iii sugar fatti acid diterpenoid posit genet correl sesquiterpenoid negat genet correl bark strip mammalian herbivor bennett wallabi macropus rufogriseus onset brows trade height detect select higher amount sesquiterpenoid howev overal result show potenti incorpor chemic trait breedingdeploy programm quantit genet analys near infrar predict chemic trait produc associ mammalian bark strip most conform obtain use standard wet chemistri | D028223 | T002 |
34,663,916 | genom health data generat uk view uk genom health data generat three major context healthcar system base clinic indic larg scale research programm purchas direct consum genet test recent deliv hybrid clinicalresearch programm genom project set scene new genom medicin servic nation health servic aim deliv consist equit care inform genom provid data inform academ industri research develop parallel larg scale research studi futur health uk govern industri invest aim recruit million volunt support research intend improv earli detect risk stratif earli intervent chronic diseas explor current model genom health data generat intersect understand clinic ethic legal polici social issu aris intersect conduct seri five multidisciplinari panel discuss attend invit stakehold meet record transcrib present summari issu identifi genom test attribut reason generat genom health data individu motiv seek genom data health servic impact role genet counsel equiti data use secur consent govern regul conclud suggest polici consider | D023281;D013222 | T091;T064 |
34,663,915 | rai altern probe identifi addit gastroesophag adenocarcinoma case amplifi follow equivoc fluoresc situ hybrid test experi nation refer laboratori colleg american pathologistsamerican societi clinic oncolog recommend test prior initi target therapi patient advanc gastroesophag adenocarcinoma gea use immunohistochemistri ihc follow fluoresc situ hybrid fish case equivoc score result ihc fish result consid indetermin hercep ratio averag cep copi number copi number count addit tumor cell indetermin result may resolv use altern chromosom probe rai purpos studi review experi rai altern probe fish test gea larg refer laboratori set esophag gastroesophag gastric adenocarcinoma receiv fish test lab includ hercep rai ratio averag cep rai signal per cell record gea test perform lab studi period amplifi non amplifi indetermin follow rai test indetermin case reclassifi non amplifi reclassifi amplifi increas total amplifi case correl averag cep rai copi number case weak r summari use altern probe rai reclassifi origin fish indetermin gastroesophag carcinoma amplifi make elig target therapi | D000230;D001943 | T191 |
34,663,913 | probiot consumpt influenc univers adapt mutat indigen human mous gut microbiota adapt evolut indigen intestin microb deriv probiot critic safeti efficaci evalu probiot yet still larg underexplor public access dataset demonstr probiot consumpt lead widespread singl nucleotid variant snvs nativ microbiota interest probiot strain introduc far snvs mous gut human furthermor pattern probiot induc snvs high probiot strain specif common snvs faecalibacterium prausnitzii genom identifi cross studi might lead chang bacteri protein structur near f prausnitzii snvs inherit six month independ human cohort wherea half transient occur collect studi substanti extend understand co evolut probiot indigen gut microbiota highlight import assess probiot efficaci safeti integr manner | D000220;D009154 | T070;T045 |
34,663,912 | allogen blood marrow transplant haploident donor post transplant cyclophosphamid patient myelofibrosi multicent studi report result multicent retrospect studi adult patient underw haploident blood marrow transplant haplo bmt post transplant cyclophosphamid ptci chronic phase myelofibrosi median age bmt year rang condit regimen reduc intens nonmyeloabl peripher blood graft use median follow month rang year overal surviv relaps free surviv rfs graft versus host diseas gvhd free rfs ci ci ci cumul incid non relaps mortal relaps ci ci year spleen size cm prior splenectomi hr ci p bone marrow graft hr ci p associ increas incid relaps cumul incid acut gvhd grade month extens chronic gvhd neutrophil engraft report patient median day rang conclus haplo bmt ptci feasibl patient myelofibrosi splenomegali cm bone marrow graft associ higher incid relaps studi | D016026 | T061 |
34,663,910 | first languag instruct transfer major languag skill increas number immigr children mani countri question prepar educ becom high salient studi examin effect first languag instruct children engag school may later transfer better major languag outcom random control trial denmark n took asset base approach student cultur linguist background found first languag instruct major languag learner averag age year reduc behaviour problem school increas school satisfact parent engag saw immedi effect spoken first languag skill one year intervent end read skill major languag substanti improv half improv could explain reduc behaviour problem result therebi indic asset base approach student linguist cultur background help ensur first languag instruct transfer major languag skill | D007802;D011932 | T171;T056 |
34,663,908 | msa drive ferroptosi resist calcium restrict lipid remodel ferroptosi iron depend form cell death driven biochem process promot oxid within lipid compart calcium ca signal molecul divers cellular process migrat neurotransmiss cell death uncov crucial link ferroptosi ca identif novel tetraspanin msa msa local endoplasm reticulum block ferroptosi deplet lumin ca store reprogram membran phospholipid ferroptosi resist speci specif prolong ca deplet inhibit lipid elong desatur drive lipid droplet dispers format shorter satur ether lipid protect phospholipid ferroptot reactiv speci demonstr increas lumin ca level preferenti sensit refractori cancer cell line summari msa regul anti ferroptot lipid reservoir provid key resist mechan distinct antioxid lipid detoxif pathway manipul ca homeostasi offer compel strategi balanc cellular lipid cell surviv ferroptosi associ diseas | D001669;D000079403 | T043;T044;T070 |
34,663,906 | function recoveri germ line follow splice collaps splice intron precursor messeng rna pre mrna transcript essenti translat function protein report previous uncharacter caenorhabd elegan protein mog act pre mrna splice factor deplet mog c elegan germ line caus intron retent germlin express gene imped germ cell cycl caus defect nuclear morpholog germ cell ident steril despit deleteri consequ caus mog loss adult germ line function recov produc viabl fertil progeni mog restor germlin recoveri depend burst apoptosi like clear defect germ cell viabl gamet generat prolifer germ cell progenitor zone togeth find reveal mog essenti germ cell develop germ line function recov collaps rna splice | D017173;D029742 | T204;T116 |
34,663,905 | appropri exercis level attenu gut dysbiosi valer acid increas improv neuroplast cognit function surgeri mice postop cognit dysfunct pocd affect outcom million patient year age risk factor pocd show surgeri induc learn memori dysfunct adult mice transplant fece surgeri mice control mice led learn memori impair non surgeri mice low intens exercis improv learn memori surgeri mice exercis attenu surgeri induc neuroinflamm decreas gut microbiota divers exercis effect present non exercis mice receiv fece exercis mice exercis reduc valer acid gut microbiota product blood valer acid worsen neuroinflamm learn memori exercis mice surgeri downstream effect exercis includ attenu growth factor decreas maintain astrocyt phenotyp form possibl via decreas c signal improv neuroplast similar result adult mice exercis attenu learn memori impair old mice surgeri old mice receiv fece old exercis mice better learn memori receiv control old mous fece surgeri increas blood valer acid valer acid block exercis effect learn memori old surgeri mice exercis stabil gut microbiota reduc neuroinflamm attenu growth factor decreas preserv neuroplast old mice surgeri result provid direct evid gut microbiota alter contribut pocd develop valer acid mediat effect potenti target brain health low intens exercis stabil gut microbiota presenc insult surgeri | D060825;D064806;D010805 | T048;T047;T038;T046 |
34,663,904 | modifi brain methylom alkbh mediat demethyl new contend synapt tag synapt plastic process underli learn memori format requir rna translat local synaps synapt tag hypothesi previous propos explain mrnas avail specif activ synaps howev rna regul transcript silenc process part tag process still unknown modif rna n methyladenosin influenc cellular fate mrna advanc microscopi show demethyl eras protein alkbh occur activ synapt ribosom synaps short term plastic demonstr activ glutamaterg post synapt site ythdf ythdf reader alkbh eras protein increas co localis modifi rnas reader show high co localis modifi rnas late stage plastic ythdf ythfdf reader also exhibit differenti role synapt matur suggest tempor subcellular abund may determin specif function sequenc human parahippocampus brain tissu reveal distinct white grey matter methylom profil indic cellular context fundament factor dictat regul pathway howev neuron glial cell rich tissu effector protein modifi epitranscript posttransl modif process coregul protein cascad hypothesis avail effector protein machineri conjunct rna modif may import format condens synapt nanodomain assembl liquid liquid phase separ find support demethyl alkbh intrins compon synapt tag hypothesi molecular switch lead alter rna methylom synapt dysfunct potenti revers diseas state | D000081122;D013569 | T028;T030 |
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