PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,663,902 | live experi stress black hispan mother hospit preterm infant neonat intens care unit character live experi stress associ preterm infant hospit nicu among black hispan mother | D007363;D009035 | T092;T093;T073;T099 |
34,663,901 | cultur research communic neonat intens care unit key stakehold perspect assess perspect neonatologist neonat nurs parent research relat educ communic practic neonat intens care unit nicu | D007363;D000072221 | T097;T093;T073 |
34,663,900 | valu cranial ultrasound initi therapeut hypothermia neonat encephalopathi variat clinic practic use cranial ultrasound cus time initi therapeut hypothermia th neonat encephalopathi role cus select patient may benefit th exclud th may impos risk unknown | D001927;D007036;D020925;D007232 | T047;T061 |
34,663,899 | acut right ventricular failur associ pulmonari hypertens pediatr understand hemodynam profil pulmonari hypertens phtn common patholog pediatr aris divers array etiolog manifest equal divers patient popul inpati manag infant children may complic dynam time sever increas pulmonari vascular resist pvr right ventricular rv afterload yet absent cognit access heurist field wherebi provid reconcil various clinic manifest observ understand cardiac physiolog play therefor appropri physiolog driven intervent describ herein framework understand pathophysiolog four clinic phenotyp driven two echocardiograph patient characterist presenc absenc atrial communic capac right ventricl maintain ventricular vascular coupl applic paradigm may facilit accur interpret observ clinic data align treatment strategi under pathophysiolog | D006333;D006976;D010372;D018497 | T091;T047;T046 |
34,663,893 | weight loss threshold bariatr surgeri cardiovascular outcom better whether extent weight loss wl modul bariatr surgeri bs cardiovascular benefit scarc assess sever wl threshold common use classifi bs patient good poor respond without proven clinic relev examin relationship magnitud wl bs post surgeri major advers cardiovascular event mace incid also compar perform three differ insuffici weight loss iwl criteria associ mace | D000077962 | T032 |
34,663,885 | fit consequ target gene flow counter impact dri climat terrestri breed frog target gene flow tgf could bolster adapt potenti isol popul threaten climat chang could also lead outbreed depress explor possibl creat mix within popul cross terrestri breed frog speci threaten dri climat rear embryo crawl frog pseudophryn guentheri wet dri soil quantifi fit relat trait upon hatch tgf produc mix outcom hybrid depend cross direct origin gamet sex north south cross led low embryon surviv egg southern origin high malform rate egg northern popul convers east west cross led one instanc hybrid vigour evid increas fit desicc toler hybrid offspr relat offspr produc within popul cross contrast result highlight need experiment evalu outcom tgf focal speci across generat prior implement manag action | D057231;D004777;D051456;D056084 | T082;T045;T067;T081;T070 |
34,663,881 | visibl blue light inhibit infect replic sar cov dose well toler human respiratori tissu deliveri safe visibl wavelength light effect pathogen agnost countermeasur would expand current portfolio sar cov intervent strategi beyond convent approach vaccin antibodi antivir therapeut employ custom biolog light unit incorpor optic engin light emit diod led array har monochromat wavelength light uniform deliveri across biolog surfac demonstr primari human trachealbronchi deriv epitheli tissu toler high dose narrow spectral band visibl light center peak wavelength nm extend studi vero e cell understand light may influenc viabil mammalian cell line convent use assay sar cov exposur singl cell monolay vero e cell similar dose nm blue light result viabil depend dose cell densiti dose nm blue light well toler vero e cell also inhibit infect replic cell associ sar cov h post infect singl five minut light exposur moreov nm blue light inactiv cell free betacoronavirus includ sar cov mer cov sar cov dose depend manner import clinic applic dose nm blue light dramat inhibit sar cov infect replic primari human trachealbronchi tissu safe dose visibl light consid part strateg portfolio develop sar cov therapeut countermeasur mitig coronavirus diseas covid | D008027;D000086402 | T070;T005 |
34,663,880 | unravel role error prone dna polymeras shape cancer genom mutagenesi key hallmark enabl characterist cancer cell yet divers under mutagen mechan shape cancer genom understood review consid emerg challeng determin dna damag respons pathway toler repair act upon specif form dna damag generat mutat characterist tumor dna polymeras typic ultim mutagen effector dna repair pathway therefor understand contribut dna polymeras critic develop comprehens pictur mutagen mechan tumor select appropri dna polymeras whether error free error prone particular dna templat critic mainten genom stabil review differ mode dna polymeras dysregul includ mutat polymorph express polymeras associ activ base upon recent find connect dna polymeras specif mechan mutagenesi propos compens dna repair defect error prone polymeras may general paradigm mold mutat landscap cancer cell notabl demonstr correl error prone polymeras express mutat burden subset patient tumor cancer genom atlas identifi mechanist hypothes test contrast experiment approach broad genom wide strategi approach narrow focus hundr base pair dna addit consid recent develop comput annot patient tumor data identifi pattern mutagenesi final discuss innov futur experi develop comprehens portrait mutagen mechan human tumor | D004249;D004260;D015894;D042822;D009154 | T049;T028;T045 |
34,663,879 | loss wild type kras allel promot pancreat cancer progress function activ yap human pancreat ductal adenocarcinoma pdac harbor one kras mutant allel often display increas genom loss remain wild type wt allel known loh kras tumor progress metastasi yet molecular ramif wt allel loss unknown studi show restor wt kras express human pdac cell line loh kras signific attenu malign pdac cell vitro vivo demonstr tumor suppress role wt kras allel rna seq identifi hippo signal pathway posit regul wt kras pdac cell accord observ pdac cell loh kras exhibit increas nuclear local activ transcript co activ yap mechanist discov wt kras express sequest yap nucleus enhanc zeta interact phosphoryl yap consist express constitut activ yap mutant pdac cell bypass growth inhibitori effect wt kras patient sampl found yap activ gene signific upregul tumor loh kras yap nuclear local predict poor surviv pdac patient collect result reveal wt allel loss lead function activ yap enhanc tumor malign explain select advantag tumor cell loh kras pancreat cancer clonal evolut progress metastasi taken consider futur therapeut strategi target kras | D015972;D019656 | T045 |
34,663,877 | singl cell rna sequenc reveal distinct tumor microenvironment pattern lung adenocarcinoma recent develop immuno oncolog demonstr cancer cell also tumor microenviron guid precis medicin comprehens depth character tumor microenviron challeng sinc cell popul divers import even scarc identifi clinic relev microenvironment cancer featur appli singl cell rna sequenc ten human lung adenocarcinoma ten normal control tissu analys reveal heterogen carcinoma cell transcriptom reflect histolog grade oncogen pathway activ two distinct microenvironment pattern immun activ cpe microenviron compos cancer associ myofibroblast proinflammatori monocyt deriv macrophag plasmacytoid dendrit cell exhaust cd cell prognost unfavor contrast inert nmc microenviron character normal like myofibroblast non inflammatori monocyt deriv macrophag nk cell myeloid dendrit cell convent cell associ favor prognosi microenvironment marker gene signatur identifi singl cell profil progonost valu bulk tumor profil summari singl cell rna profil lung adenocarcinoma provid addit prognost inform base microenviron may help predict therapi respons reveal possibl target cell popul futur therapeut approach | D015972;D059467;D059016 | T086;T070;T045;T081 |
34,663,867 | optogenet stimul later hypothalam orexindynorphin input ventral tegment area potenti mesolimb dopamin neurotransmiss promot reward seek behaviour reward reinforc process critic surviv propag gene numer brain system underli process cardin role ascrib mesolimb dopamin howev ventral tegment area vta dopamin neuron receiv complex innerv various neuromodulatori factor includ input later hypothalam lh orexinhypocretin neuron also express co releas neuropeptid dynorphin dynorphin vta induc avers condit kappa opioid receptor kor decreas dopamin administ intra vta exogen applic orexin orexin receptor oxr antagonist vta bidirect modul dopamin driven motiv reward seek behaviour includ attribut motiv valu primari reward associ condit stimuli howev effect endogen stimul lh orexindynorphin contain project vta potenti contribut co releas dynorphin mesolimb dopamin reward relat process remain uncharacteris combin optogenet electrochem behaviour approach examin found optic stimul lh orexindynorphin input vta potenti mesolimb dopamin neurotransmiss nucleus accumben nac core produc real time condit place prefer increas food cue direct orient pavlovian condit procedur lh orexindynorphin potenti nac dopamin releas real time place prefer block oxr kor antagonist thus reward effect associ optic stimul lh orexindynorphin input vta predomin driven orexin rather dynorphin | D004298;D017557 | T023;T121;T109;T123 |
34,663,866 | effect dietari mannan oligosaccharid fructo oligosaccharid physico chemic indic antioxid oxid stabil broiler chicken meat object present studi investig potenti prebiot mannan oligosaccharid mos fructo oligosaccharid fos replac antibiot growth promot relationship physico chemic indic antioxid oxid stabil carcass trait broiler chicken meat accord day old broiler chick uniform bodi weight divid treatment group replic bird replic six corn base dietari treatment formul viz control diet bacitracin methylen di salicyl mos mos fos fos signific p increas cut part yield reduct cholesterol fat content mos group water hold capac whc extract releas volum erv increas p mos supplement group dpph diphenyl picrylhydrazi higher p lipid oxid free fatti acid thio barbitur acid reactiv substanc lower p group standard plate count spc staphylococcus coliform count decreas p group thus conclud mannan oligosaccharid mos may incorpor level diet improv physico chemic indic antioxid oxid stabil carcass characterist broiler chicken meat may suitabl replac antibiot growth promot | D008460 | T168 |
34,663,858 | asymptomat covid adult outpati identifi signific viabl sar cov shedder differenti kinet rna load infecti viral level upper respiratori tract asymptomat symptomat sar cov infect adult outpati remain unclear limit recommend may guid clinic manag infect control measur occup health decis present investig french adult outpati posit upper respiratori tract sar cov rna detect quantit rt pcr assay covid asymptomat adult asymptomat viral shedder mean high rna viral load ct valu median valu signific higher observ symptomat subject p posit cell cultur assay upper respiratori tract specimen find indic covid asymptomat adult outpati signific viabl sar cov shedder upper respiratori tract play major potenti role sar cov transmitt various epidemiolog transmiss chain promot covid resurg popul | D010045;D000086402;D017201 | T046;T005;T101 |
34,663,829 | phosphoproteom profil uncov key role cdks tnf signal tumor necrosi factor tnf one cytokin success target therapi inflammatori diseas howev block well studi pleiotrop ligand caus dramat side effect reason system level proteom analysi tnf signal could dissect divers function offer base develop target therapi therefor combin phosphoproteom time cours experi subcellular local kinas inhibitor analysi identifi function modul protein phosphoryl major regul phosphoryl event assign upstream kinas inhibit master kinas spatial proteom reveal phosphoryl depend transloc hundr protein upon tnf stimul phosphoproteom analysi tnf induc apoptosi necroptosi uncov key role transcript cyclin depend kinas activ promot cytokin product prevent excess cell death downstream tnf signal receptor resourc tnf induc pathway site explor http tnfviewerbiochemmpgd | D015398 | T043;T044 |
34,663,821 | hierarch cellular structur model unravel univers power law rheolog behavior live cell live cell complex soft materi fascin mechan properti strike featur regardless type state cell exhibit univers power law rheolog behavior date still captur singl theoret model propos cellular structur model account essenti mechan respons cell membran cytoplasm cytoskeleton demonstr model natur reproduc univers power law characterist cell rheolog well power law expon relat cellular stiff import power law expon quantit tune rang found type cell vari stiff architectur cytoskeleton base structur characterist develop self similar hierarch model spontan captur power law characterist creep complianc time complex modulus frequenc present model suggest mechan respons cell may depend primarili generic architectur mechan rather specif molecular properti | D008961;D012212 | T059;T057;T073 |
34,663,819 | incorpor function prior improv polygen predict accuraci uk biobank andm data set polygen risk predict wide investig topic promis clinic applic genet variant function region genom enrich complex trait herit introduc method polygen predict ldpred funct leverag trait specif function prior increas predict accuraci fit prior use recent develop baselin ld model includ code conserv regulatori ld relat annot analyt estim posterior mean causal effect size use cross valid regular estim improv predict accuraci spars architectur appli ldpred funct predict high herit trait uk biobank avg n k train data ldpred funct attain relat improv averag predict accuraci avg predict r highest r height compar sbayesr best method incorpor function inform height meta analyz train data uk biobank andm cohort n k increas predict r result show incorpor function prior improv polygen predict accuraci consist function architectur complex trait | D018070;D020412 | T032;T093;T045 |
34,663,818 | tet mutat associ hypermethyl key regulatori enhanc normal malign hematopoiesi mutat epigenet modifi tet frequent myeloid malign clonal hematopoiesi indetermin potenti chip clonal cytopenia undetermin signific ccus investig associ tet mutat dna methyl whole blood elder twin patient ccus healthi control find tet mutat associ dna hypermethyl enhanc site whole blood chip granulocyt mononuclear cell ccus hypermethyl site associ leukocyt function immun respons et relat cebp relat transcript factor motif major tet associ hypermethyl site share chip aml find set aml specif hypermethyl loci activ enhanc element hematopoiet stem cell summari show tet mutat associ hypermethyl enhanc involv myeloid differenti chip ccus aml patient | D019175;D004742;D009154 | T044;T114;T045;T123 |
34,663,816 | singl cell transcriptom analysi tumor ecosystem under initi progress papillari thyroid carcinoma tumor ecosystem papillari thyroid carcinoma ptc poor character use singl cell rna sequenc profil transcriptom cell patient paratumor localizedadvanc tumor initi treatedrecurr lymph node radioact iodin rai refractori distant metastas cover comprehens clinic cours ptc data identifi cancer prime premalign thyrocyt popul normal morpholog alter transcriptom along development trajectori also discov three phenotyp malign thyrocyt follicular like partial epitheli mesenchym transit like dedifferenti like whose composit shape bulk molecular subtyp tumor characterist rai respons furthermor uncov distinct braf like b subtyp predomin dedifferenti like thyrocyt enrich cancer associ fibroblast wors prognosi promis prospect immunotherapi moreov potenti vascular immun crosstalk ptc provid theoret basi combin anti angiogen immunotherapi togeth find provid insight ptc ecosystem suggest potenti prognost therapeut implic | D017753;D059467 | T086;T070;T082;T081 |
34,663,802 | relationship lysosom dyshomeostasi progress diabet kidney diseas lysosom organell involv cell metabol wast degrad cellular materi circul play key role mainten cellular physiolog homeostasi compar lysosom content organ kidney abund lysosom abnorm associ occurr develop certain renal diseas lysosom structur function intrins renal cell impair diabet kidney diseas dkd promot lysosom biosynthesi andor restor lysosom function repair damag podocyt proxim tubular epitheli cell delay progress dkd lysosom homeostasi mainten may advantag allevi dkd systemat review latest advanc relationship lysosom dyshomeostasi progress dkd base recent literatur elucid mechan renal injuri diabet mellitus highlight applic potenti lysosom homeostasi mainten new prevent treatment strategi dkd howev research screen effect intervent lysosom dyshomeostasi still infanc thus focus futur research studi screen cell specif lysosom function regul target accord differ stage dkd realiz control target regul cell lysosom function dkd key success clinic develop therapeut strategi | D018450;D006706 | T033;T046;T038 |
34,663,799 | prefront patholog influenc pathway apathi cognit declin non dementia elder purpos studi investig complex connect apathi cognit declin remain unclear total non dementia elder alzheim diseas neuroimag initi adni databas receiv year follow divid apathi negat group particip apathi posit group particip neuropsychiatr inventori npi apathi subitem cerebrospin fluid csf ad biomark amyloid pet measur longitudin chang assess use linear mix effect model risk factor cognit declin apathi convers explor cox proport hazard model mediat effect patholog cognit investig use causal mediat analysi apathi syndrom associ faster impair cognit elev burden effect apathi cognit function life qualiti mediat patholog includ csf total tau ratio deposit prefront region apathi syndrom risk factor cognit deterior meanwhil frontal burden risk factor apathi convers apathi syndrom earli manifest cognit declin bidirect role apathi syndrom patholog prefront patholog influenc pathway apathi cognit declin | D000544;D057565;D060825 | T048;T047 |
34,663,797 | downregul phlpp induc endoplasm reticulum stress promot eif phosphoryl chemoresist colon cancer aberr activ endoplasm reticulum er stress extrins intrins factor contribut tumorigenesi resist chemotherapi various cancer type previous studi shown downregul phlpp novel famili serthr protein phosphatas promot tumor initi progress investig function interact er stress phlpp express colon cancer found induct er stress signific decreas express phlpp protein proteasom depend mechan knockdown phlpp increas phosphoryl eif well express autophagi associ gene downstream eifatf signal pathway addit result immunoprecipit experi show phlpp interact eif interact enhanc er stress function knockdown phlpp improv cell surviv er stress condit wherea overexpress degrad resist mutant phlpp opposit effect taken togeth studi identifi er stress novel mechan trigger phlpp downregul phlpp loss promot chemoresist upregul eifatf signal axi colon cancer cell | D019008;D059865 | T049;T042;T038 |
34,663,796 | spontan travel wave natur emerg horizont fiber time delay travel local asynchron irregular state studi sensori evok neuron respons often focus mean spike rate fluctuat treat intern generat nois howev fluctuat spontan activ often organ travel wave shape stimulus evok respons perceptu sensit mechan under wave unknown unclear whether wave consist low rate weak correl asynchron irregular dynam observ cortic record describ larg scale comput model topograph organ connect conduct delay relev biolog scale find spontan travel wave general properti network travel wave occur model spars small fraction neuron particip individu wave consequ induc measur spike correl remain consist local asynchron irregular state modul local network state shape respons incom input observ vivo | D008959 | T170 |
34,663,790 | molecular genom characteris panel human anal cancer cell line anal cancer rare diseas doubl incid last four decad current treatment surviv patient diseas chang substanti period time due part pauciti preclin model assess new therapeut option address hiatus set establish valid characteris panel human anal squamous cell carcinoma ascc cell line employ explant techniqu use fresh human ascc tumour tissu panel five human ascc cell line valid confirm origin squamous featur tumourigen follow molecular genom whole exom sequenc characteris panel recapitul genet molecular characterist previous describ ascc includ phosphoinositid kinas pik mutat three human papillomavirus hpv posit line tp mutat hpv negat line cell line demonstr abil form tumouroid retain tumourigen potenti upon xenotransplant vari induc express major histocompat complex class mhc class program cell death ligand pd l observ differenti respons standard chemotherapi radiotherapi pik specif molecular target agent vitro correl clinic respons patient tumour deriv anticip novel panel human ascc cell line form valuabl resourc futur studi biolog therapeut rare diseas | D023281 | T091 |
34,663,788 | elk mediat lncrna snhg promot gastric cancer progress interact ezh regul mir c pnotch axi long non code rnas lncrnas play import regulatori role initi progress various cancer howev biolog role potenti mechan lncrnas gastric cancer remain unclear report express lncrna snhg small nucleolar rna host gene signific increas gc gastric cancer tissu cell confer poor prognosi patient knockdown snhg inhibit prolifer invas abil gc cell moreov identifi transcript factor elk et transcript factor elk could promot snhg express gc cell addit use rna pull follow ms assay found snhg direct bound ezh enhanc zest polycomb repress complex subunit suppress express tumor suppressor gene time snhg spong mir c p increas notch notch receptor express taken togeth find demonstr role snhg promot prolifer invas gc cell reveal new regulatori mechan snhg gc cell snhg promis lncrna biomark diagnosi prognosi potenti target gc treatment | D018450 | T033;T046 |
34,663,787 | modifi predictor suicid ideat psychotherapi late life major depress machin learn approach studi aim identifi subgroup depress older adult distinct trajectori suicid ideat brief psychotherapi detect modifi predictor membership trajectori suicid ideat latent growth mix model use identifi trajectori presenc suicid ideat particip random control trial compar problem solv therapi engag therapi older adult major depress week predictor membership trajectori suicid ideat identifi converg four machin learn model ie least absolut shrinkag select oper logist regress random forest gradient boost machin classif tree cours suicid ideat best captur two trajectori favor unfavor trajectori compris particip respect member favor trajectori suicid ideat week contrast member unfavor trajectori probabl suicid ideat treatment end converg find four machin learn model identifi hopeless neurotic low general self efficaci strongest predictor membership unfavor trajectori suicid ideat psychotherapi assess suicid risk includ hopeless neurotic general self efficaci predictor unfavor cours suicid ideat depress older adult receiv psychotherapi psychotherapeut intervent exist hopeless emot reactiv relat neurotic low self efficaci use therapi may improv cours suicid ideat | D003865;D013405 | T033;T048 |
34,663,786 | fatti acid dysregul anterior cingul cortex depress suicid histori child abus child abus ca strong increas lifetim risk suffer major depress predict unfavor cours ill sever ca associ specif dysregul oligodendrocyt function thinner myelin sheath human anterior cingul cortex acc white matter given myelin extrem lipid rich plausibl find may accompani disrupt lipid profil compos myelin sheath import explor sinc composit fatti acid fa myelin phospholipid influenc stabil permeabl compact therefor object studi quantifi compar fa concentr postmortem acc white matter cholin glycerophospholipid pool chogpl key myelin phospholipid pool adult depress suicid histori ca ds ca match depress suicid without ca ds healthi non psychiatr control ctrl total lipid extract subject accord folch method separ respect class use thin layer chromatographi fa methyl ester chogpl fraction quantifi use gas chromatographi analysi reveal specif effect ca fas arachidon acid synthesi pathway valid rna sequenc data furthermor concentr fas found decreas age extend previous molecular level find link ca alter myelin acc result provid insight regard white matter alter associ earli life advers | D002649;D003865;D013405 | T033;T048 |
34,663,785 | mitochondri genom regul tfam modul head neck tumourigenesi intracellular metabol reprogram activ oncogen effector mitochondri transcript factor tfam act key regulatori control mitochondri dna mtdna impact tfam mtdna modul carcinogenesi controversi current studi aim defin tfam mediat regul head neck cancer hnc multifacet analys hnc cell genet manipul tfam perform clinic associ tfam mtdna encod electron transport chain etc gene regul hnc tumourigenesi also examin hnc specimen cellular level tfam silenc led enhanc cell growth motil chemoresist wherea enforc tfam express signific revers phenotyp chang tfam mediat cellular chang result metabol reprogram direct metabol toward aerob glycolysi base detect less respiratori capac accompani greater lactat product andor enhanc erk akt mtorc signal activ respons tfam induc mtdna perturb clinic impact tfam mtdna defin carcinogen induc mous tongu cancer clinic human hnc tissu result show tfam mtdna express signific drop tumour compar normal counterpart negat correl diseas progress collect data uncov tumour suppress role tfam mtdna determin hnc oncogen potenti pave way develop tfammtdna base scheme hnc diagnosi | D054629;D009857 | T028 |
34,663,784 | noradrenerg arous encod revers cours system consolid human common assum episod memori undergo time depend system consolid process hippocampus depend memori eventu becom reliant neocort area show system consolid dynam experiment manipul even revers combin singl pharmacolog elev post encod noradrenerg activ adrenoceptor antagonist yohimbin fmri scan encod recognit test either day later show yohimbin administr contrast placebo lead time depend increas hippocamp activ multivari encod retriev pattern similar indic episod reinstat day accompani time depend decreas neocort activ behavior neural chang link reduc memori declin time yohimbin intak find indic noradrenerg activ short encod may alter even revers system consolid human thus maintain vivid memori time | D001143 | T041 |
34,663,783 | reduc hippocamp inhibit enhanc autism epilepsi comorbid mice lack neuropilin neuropilin receptor secret semaphorin ligand play key role brain circuit develop regul numer crucial neuron process includ matur synaps migrat gabaerg interneuron consist development role neuropilin nrp locus contain polymorph patient autism spectrum disord asd nrp defici mice show autism like behavior deficit propens develop seizur order determin pathophysiolog nrp defici examin hippocamp number interneuron subtyp inhibitori regul hippocamp ca pyramid neuron mice lack one copi nrp immunostain interneuron subtyp reveal nrp mice reduc number parvalbumin somatostatin neuropeptid cell main ca whole cell record identifi reduc fire hyperpolar shift rest membran potenti ca pyramid neuron nrp nrp mice compar age match wild type control indic decreas intrins excit simultan frequenc amplitud spontan inhibitori postsynapt current sipsc reduc nrp defici mice convuls dose kainic acid evok electrograph behavior seizur signific shorter latenc longer durat higher sever nrp compar nrp anim final nrp nrp nrp mice impair cognit flexibl demonstr reward base revers learn task associ hippocamp circuit function togeth data demonstr broad reduct interneuron subtyp compromis inhibit ca nrp mice could contribut heighten seizur suscept behavior deficit consist asdepilepsi phenotyp | D000067877;D001321;D004827 | T033;T048;T047 |
34,663,781 | downregul kainat receptor regul gabaerg transmiss amygdala earli life stress associ anxieti like behavior rodent earli life stress el well character risk factor mood anxieti disord gabaerg microcircuit amygdala critic implic anxieti howev whether function alter el known identifi novel mechan kainat receptor kar modul feedforward inhibit later amygdala la show mechan downregul el induc matern separ ms specif show control rat ms endogen activ gluk subunit contain kar disinhibit la princip neuron activ cortic affer gluk antagon attenu excit parvalbumin pv express interneuron result loss pv depend inhibitori control increas fire somatostatin express interneuron inactiv grik express local adult amygdala reduc ongo gabaerg transmiss suffici produc mild anxieti like behavior phenotyp interest ms gluk depend phenotyp show similar gender specif detect male femal rodent data identifi novel kar depend mechan cell type project specif function modul la gabaerg microcircuit suggest loss gluk kar function contribut anxiogenesi el | D000076783;D018092 | T033;T116;T192 |
34,663,779 | challeng case use manta ray skin flap sever post traumat first web space contractur background first web space contractur affect thumb function grasp capac patholog alter normal anatomi result decreas abil use hand appropri releas resurfac need restor normal hand function principl success treatment also includ provid healthi compliant skin tension free closur smooth heal period manta ray skin flap util children allow posit much local skin possibl minim dorsal scar techniqu potenti use adult less skin plastic pliabil case report present case year old patient sever first web space contractur domin hand primari concern patient loss hand mobil limit grasp abil inabl give proper handshak medic histori suggest gunshot wound earli childhood treat oper mild web releas point trauma insuffici outcom proceed manta ray flap techniqu use dorsal base flap palmar base flap excel result conclus although manta ray flap procedur develop moder web space contractur children combin advantag sever flap techniqu ensur suffici web space lengthen may applic older patient enough healthi unscar skin avail uniqu properti potenti led us use method challeng case | D003286;D006230;D014948 | T190;T037 |
34,663,778 | effect long cold ischemia time kidney age donor prognosi kidney transplant increas incid end stage renal diseas esrd patient life span life qualiti signific reduc kidney transplant gradual becom ideal method treat esrd shortag organ sourc becom main problem recent year china success realiz transform organ sourc voluntari donat death citizen increas year year number kidney transplant increas allevi organ shortag certain extent compar past increas proport age donor also becom inevit global problem time due sudden widespread distribut voluntari donat donor kidney problem longer cold ischem time cit probabl advers event delay renal function recoveri transplant also signific increas present littl research effect donor age long cit prognosi renal transplant paper review literatur recent year explor problem aspect elder donor long cit | D050377;D016030;D014019 | T098;T079;T061 |
34,663,777 | vogt koyanagi harada syndrom polyarthr rare clinic manifest first detail descript eros seroneg polyarthr vogt koyanagi harada syndrom portug | D001168;D014607 | T047 |
34,663,776 | one great nation maladi neurasthenia american imperi masculin anxieti turn twentieth centuri white upper middl class american turn twentieth centuri entrench battl newli discov invent mental ill call neurasthenia essay examin way medic discours neurasthenia reflect late nineteenth earli twentieth centuri white anglo saxon men belief well anxieti american valu bolster idea cultur racial sexual superior consolid conjunct medicin polit idea neurasthenia white american men maladi function mark white racial superior new immigr african american well women intellectu inferior opposit sex race impos subtl distort etiolog diagnosi neurasthenia associ specif group peopl american diseas constitut era repres patholog symptom address anglo saxon american men anxieti overcivil effeminaci racial nation decad origin respons racial sexual heterogen essay also argu neurasthenia imagin diseas address late nineteenth centuri american men spatial anxieti declin american pastor ideal caus closur frontier given treatment neurasthen men escap frontier west could rejuven wither american masculin uneasi barbar unhygien prolif immigr unruli white women fact tie spatial anxieti symptomat signifi crisi american masculin channel medic knowledg neurolog made american men racial sexual spatial anxieti function act racist misogynist nativist imperialist impuls legitim exclusionari polit techniqu toward racial sexual other us imperi expans eugen influenc immigr polici thes sens declin neurasthenia around attribut sole continu effort profession american medicin accompani recent discoveri chemic factor hormon vitamin rise psychiatri psycholog offer physician specif theori health built clinic laboratori scienc like rise decis move away neurasthen diagnosi rather cultur phenomenon reflect american ascend global power earli twentieth centuri particular first world war sustain polit order rest racial sexual hierarchi within outsid american contin american men felt longer liabl specif time test anxieti somat symptom neurasthenia ideolog cultur construct clinic entiti dramat racial sexual imperi polit turn twentieth centuri america | D008571;D009440 | T100;T048;T098 |
34,663,775 | conceal disclosur cholera crisi korea anti cholera measur repres one unsuccess quarantin case modern korea militari govern overthrew democrat govern tri amend constitut aim long term seizur power overcom cholera crisi previous scholarship emphas limit state power came control cholera epidem poor sanit system howev undeni militari govern organ facil human capit avail cholera epidem broke militari govern defend peopl cholera part revolutionari task furthermor took counsel team medic profession knowledg microbiolog possibl bacteriolog warfar north korea emerg govern respond cholera avoid crisi park chng hi militari govern prepar longterm rule provid success model cholera defens militari govern conceal distort infecti diseas inform inevit mani medic profession trust activ intern organ govern bodi media accus govern fabric cholera death statist govern fail prevent cholera crisi tighten secreci conceal fact control inform | D002771;D058872 | T047;T067 |
34,663,774 | local praziquantel product clonorchiasi control program korea ss korean parasit control program regard one success exampl health care movement korea parasit erad program conduct involv test treat million peopl cooper japan parasitologist activist particip parasit control program form common system call mass test mass treatment studi focus local process praziquantel clonorchiasi treatment product applic clonorchiasi control program parasitologist rapid introduc newli develop praziquantel korean chemist quick revers engin compound evad patent issu allow mass product praziquantel lower price turn enabl nationwid clonorchiasi control program time low price stabl suppli open privat market praziquantel howev accept understand praziquantel differ signific among stakehold govern mean polici propaganda health agenc mean mass scale control program public mean maintain convent eat habit without risk infect studi reveal materi end diseas control polici accept interpret differ actor | D003003;D003004 | T204;T047 |
34,663,773 | chang pharmaceut market fake drug problem qing period sinc ancient time fake drug market chines societi howev ming qing dynasti problem intensifi size pharmaceut market grew collect distribut structur pharmaceut product becam increas complex phenomenon separ prescript distribut drug advanc addit govern manag manufactur qualiti drug law institut design solv problem fake drug furthermor social opinion also critic widespread problem fake drug patient doctor reli various pharmacognost book medic knowledg find reliabl drug drug market meanwhil merchant particip invest commerci capit pharmaceut industri larg reput pharmaci began emerg larg citi produc drug commerci pharmaceut market public gain interest drug consum drug produc pharmaci moreov frequent problem market fake drug imit popular drug distribut name famous pharmaci stolen although fake drug univers social problem qing govern reluct strict control tri solv issu enforc ban punish local govern promin pharmaci file sever lawsuit govern theft fake drug drug name also advertis legitimaci authent drugstor public custom doctor merchant respond problem fake drug follow occup moral develop drug discrimin crack organiz disciplin file complaint govern offic advertis authent howev fake medicin easili disappear despit respons state control legisl evid pharmaceut market alreadi high commerci structur complex moreov financi benefit fake drug competit pharmaceut market public demand drug similar effect low price also affect popular fake drug henc distribut fake medicin qing societi seen phenomenon separ prescript distribut drug commerci consumpt drug competit medic market | D058110;D010594;D010604 | T121;T057;T073;T091;T131;T093;T058 |
34,663,772 | composit genealog relat network medic famili late joseon dynasti uiyeokju palsebo genealog record contain eighth generat patrilin ancestor matern grandfath father law technic offici work three field medicin linguist mathemat book cover member influenti famili monopol posit technic offic respect seem effect like kind white list paper identifi rang famili base common ancestor eight generat accord edit method book attempt various statist analysi result analysi show possibl determin size medic famili vari accord number medic bureaucrat distanc kinship famili worker three field medicin linguist mathemat also famili special medicin produc larg number medic figur ancestor medic figur main engag three field medicin linguist mathemat also small number offici charg unhak includ astronomi geographi fortun tell law art transcript distant ancestor common ancestor fifth generat proport technic offic small relat close ancestor proport technic offic especi medic offic increas seen status medic offic tend hereditari generat field activ matern grandfath father law medic figur concentr medic field result confirm influenc marit relationship network form close period medic person investig paper medic figur consid primari research subject macroscop network relat even spread three field medicin linguist mathemat network uiyeokju palsebo contain homogen hierarchi could continu domin specif field govern offic | D006282;D008511 | T097;T091 |
34,663,771 | robust neural decod kernel regress siames represent learn object brain machin interfac bmis provid direct pathway brain extern devic comput cursor prosthet great potenti motor function restor one critic limit current bmi system unstabl perform part due variabl neural signal studi show neural activ exhibit trial trial variabl prefer direct neuron frequent chang differ condit therefor fix decod function work well approach deal problem propos novel kernel regress framework nonparametr kernel regress use fit divers decod function find similar neural pattern handl neural variat caus vari tune function represent raw neural signal learn siames network constrain kinemat paramet allevi neural variat caus intrins nois task irrelev inform represent joint learn kernel regress framework end end manner neural variat tackl effect main result experi two dataset demonstr approach outperform exist method signific improv robust challeng situat limit sampl miss channel signific propos approach demonstr robust perform differ condit provid new inspir perspect toward robust bmi control | D062207 | T074 |
34,663,769 | mont carlo calcul tg dosimetri paramet intrabeam sourc spheric applic relat tg dosimetri paramet intrabeam carl zeiss meditec ag jena germani bare probe recent report ayala alvarez et al phys med biol current studi focus dosimetri character intrabeam sourc eight avail spheric applic accord tg formal use mont carlo mc simul | D001918;D011874 | T074;T059;T073;T061 |
34,663,767 | noisevoid unsupervis denois pet imag object elev nois level positron emiss tomographi pet imag lower imag qualiti quantit accuraci confound factor clinic interpret object paper develop pet imag denois techniqu base unsupervis deep learn signific recent advanc deep learn usher wide array novel denois techniqu sever success adapt pet imag reconstruct post process bulk deep learn research far focus supervis learn scheme imag denois problem requir pair noisi noiselesslow nois imag requir tend limit util method medic applic pair train dataset alway avail furthermor achiev best case perform method essenti dataset train subsequ real world applic consist imag characterist eg nois resolut etc rare case clinic data circumv challeng critic develop unsupervis techniqu obviat need pair train data approach paper adapt noisevoid techniqu reli corrupt imag alon model train pet imag denois assess perform use pet neuroimag data noisevoid unsupervis approach use blind spot network design requir singl noisi imag input therefor well suit clinic set train phase singl noisi pet imag serv input target present modifi version noisevoid base transfer learn paradigm involv group level pretrain follow individu fine tune furthermor investig impact incorpor anatom imag second input network main result valid denois techniqu use simul data base brainweb digit phantom show noisevoid pretrain andor anatom guidanc lead higher peak signal nois ratio tradit denois scheme gaussian filter anatom guid non local mean filter block match filter use noisenois denois techniqu addit benchmark clinic valid appli method human brain imag dataset clinic find consist simul result confirm translat valu noisevoid denois tool | D007091;D049268 | T066;T060 |
34,663,766 | iabr symposium meet report breath standard sampl test time covid due covid travel disrupt intern associ breath research host plan breath summit virtual symposium oral poster present event compris week long social media asynchron onlin event share research abstract poster discuss subsequ two day real time webinar platform interact featur three technic present open forum question answer commentari symposium well attend well receiv allow breath communiti share new research reconnect colleagu friend report present overview topic present various salient discuss point | D000086382 | T047;T067 |
34,663,762 | hierarch order multimod interact fusion network grade glioma signific glioma common type primari brain tumor differ grade accur grade glioma therefor signific clinic treatment plan prognost assess multipl modal magnet reson imag mri object approach studi develop noninvas deep learn method base multimod mri grade glioma focus effect multimod fusion via leverag collabor divers high order statist inform specif novel high order multimod interact modul design promot interact learn multimod knowledg effici fusion power featur express featur correl learn high order attent mechan embed interact modul model complex high order statist inform enhanc classif capabl network moreov appli increas order differ level hierarch recalibr modal stream divers order attent statist thus encourag side attent knowledg lesser paramet main result evalu effect propos scheme extens experi conduct cancer imag archiv tcia multimod brain tumor imag segment benchmark brat dataset five fold cross valid demonstr propos method achiev high predict perform area receiv oper characterist curv accuraci sensit specif valu brat tcia dataset respect | D001932;D005910 | T191 |
34,663,761 | repair critic size porcin craniofaci bone defect use collagen polycaprolacton composit biomateri regen medicin approach massiv craniomaxillofaci cmf bone defect face challeng associ scale miss bone need rapid graft defect integr challeng relat inflamm infect miner collagen scaffold shown promot mesenchym stem cell osteogenesi due porous natur materi properti mechan weak limit surgic practic previous scaffold combin print polycaprolacton pcl mesh form scaffold mesh composit increas strength promot bone format sub critic size porcin ramus defect compar perform miner collagen pcl composit pcl mesh critic size porcin ramus defect model differ overal heal respons group data demonstr broad variabl metric heal regard new bone infiltr fibrous tissu format abscess present surround implant pcl polym still present month implant overal limit success heal implant show substanti level bone regener other demonstr form new bone format result suggest target improv improv repair larg anim model accur repres cmf bone heal notabl strategi increas osteogenesi throughout implant modul immun system support repair employ shape fit tactic avoid implant micromot result fibrosi improv miner collagen scaffold involv chang pore size shape increas cell migrat osteogenesi inclus deliveri factor aid vascular ingrowth bone regener | D001672;D054457 | T122 |
34,663,759 | project base dynam tomographi object paper propos dynam tomographi framework allow move sampl imag tomograph well associ space time kinemat measur noth singl convent x ray scan approach method exploit consist projectionreconstruct oper multi scale procedur procedur compos two main part solv altern motion compens reconstruct algorithm project base measur procedur estim displac field direct project main result method appli two studi numer simul breath chest comput tomographi ct clinic cone beam ct breath patient acquir imag guidanc radiotherapi reconstruct volum initi blur motion clean motion artifact signific appli propos approach result improv reconstruct qualiti show sharper edg finer detail | D054893;D056973 | T060 |
34,663,756 | use analyt platform technolog support acceler product develop concept review case studi number product develop serious condit elig expedit program increas recent year articl present industri perspect reduc analyt life cycl step use analyt platform technolog apt support acceler biolog product develop strategi life cycl step apt method conceptu review within framework support chemistri manufactur control cmc develop acceler reduc method qualif transfer valid studi could perform provid initi valid test method remain unchang detail case studi use illustr consider initi method valid subsequ apt verif studi consider apt implement discuss suggest provid submiss apt inform regulatori file | D012107 | T170;T169;T062;T081;T096 |
34,663,749 | normat blood pressur respons exercis stress test children adolesc describ normat valu blood pressur bp respons maxim exercis childrenadolesc undergo treadmil stress test | D001827;D015992 | T032;T201 |
34,663,748 | impact mass media campaign present ambul use acut coronari syndrom nation heart foundat australia ran mass media campaign improv australian awar acut coronari syndrom ac symptom need call emerg medic servic em studi examin impact campaign emerg depart ed present em use victoria australia | D012017 | T097;T058;T170 |
34,663,746 | rational design preserv versus reduc eject fraction biomark registri precis medicin databas ambulatori patient heart failur prefer hf studi patient heart failur hf classic categoris left ventricular eject fraction lvef effort predict outcom respons specif therapi among lvef base group may suboptim part due under heterogen within clinic hf phenotyp multidimension characteris ambulatori patient without hf across lvef group need better understand manag patient hf precis manner | D012042 | T170 |
34,663,733 | digit print shape morph natur materi demonstr programm shape evolut deform induc plant base natur materi standard digit print technolog nonallergen pollen paper substrat materi show specif geometr featur architectur custom design digit print pattern modul hygrophob geometri complex shape autonom hygromorph configur frozen postprocess coat meet need wide spectrum use applic comput simul involv finit element method accompani experi develop quantit insight general framework creat complex shape eco friend natur materi potenti sustain applic scalabl manufactur | D010209;D013672 | T090;T073 |
34,663,732 | neural mechan deliber dishonesti dissoci deliber control process dishonest behavior numer studi sought proof whether peopl genuin honest test whether cognit control mechan recruit honest dishonest behavior under assumpt deliber behavior requir cognit control inhibit intuit respons howev cognit control honest dishonest behavior requir reason deliber across neuroimag studi subject investig differ form honest dishonest behavior demonstr mani brain region previous implic dishonesti may reflect general cognit mechan argu motivationalvolit dimens central deliber provid evid motiv dishonest behavior recruit perigenu anterior cingul cortex work question view cognit control hallmark dishonesti | D001519;D008192 | T053;T055 |
34,663,731 | genet sourc track human urinari exosom genet origin nanoscal extracellular vesicl bodi fluid remain unclear perform track analysi urinari exosom via rna sequenc reveal urin exosom most express tissu specif gene bladder close cell genet relationship endotheli cell basal cell monocyt dendrit cell track differenti express gene cancer correspond enrich analysi show urin exosom intens involv immun activ indic may har reliabl biomark noninvas liquid biopsi cancer genom diagnost precis medicin | D014556 | T031 |
34,663,730 | critic regul follicular helper cell differenti function g signal gpcr g protein mediat signal transduct contribut spatiotempor interact immun cell fine tune facilit process inflamm host protect beyond howev g protein contribut helper cell subset differenti adapt respons underappreci found g signal cell play crucial role induc follicular helper tfh cell differenti vivo cell specif g defici mice diminish tfh cell respons cell intrins manner respons immun lymphocyt choriomening virus infect allergen challeng moreov g defici tfh cell express reduc level bcl cxcr function impair abil adher stimul b cell mechanist g defici tfh cell harbor defect rho rock activ rho agonist treatment recuper tfh cell differenti express bcl cxcr tfh cell cell specif g defici mice convers rock inhibitor treatment hamper tfh cell differenti wild type mice find unveil crucial regulatori role g rho rock axi optim tfh cell differenti function might promis target pharmacolog intervent vaccin develop well antibodi mediat immun disord | D002454;D015398 | T043;T044 |
34,663,728 | covid lockdown drive declin activ fire southeastern unit state fire common ecosystem process forest grassland worldwid increas ignit control human activ either suppress wildfir intent ignit prescrib fire southeastern unit state lead nation prescrib fire burn ca countri extent annual covid pandem radic chang human behavior workplac implement social distanc guidelin provid opportun evalu relationship human fire fire manag plan postpon cancel use activ fire data satellit base observ found southeastern unit state covid led reduct fire activ compar averag reduct pronounc feder manag land averag compar past averag compar past decad declin fire activ part affect unusu wet februari covid shutdown began mid march despit wet spring predict number activ fire detect still lower expect confirm covid signal ignit addit prescrib fire manag statist report us feder agenc confirm satellit observ show follow wet februari mid march covid shutdown cumul burn area approach record high across region fire return interv southeastern unit state frequent covid fire impact contribut increas backlog necessari fire manag activ affect biodivers futur fire danger | D058873;D000085762;D000086402 | T005;T054;T067 |
34,663,723 | aggreg deforest reduct rollout communiti land titl indonesia yet indonesia million peopl live within km state forest govern indonesia plan grant communiti titl million hectar land communiti live around forest titl allow use nontimb forest product practic agroforestri oper tourism busi select log design product zone estim earli effect program rollout use data delin introduct date communiti forest titl million hectar land across countri find contrari object program communiti titl aim conserv decreas deforest anyth tend increas forest loss contrast communiti titl zone aim timber product decreas deforest albeit higher baselin forest loss rate | D065928 | T070 |
34,663,722 | peopl toler inequ express term individu rather group top despit ever grow econom gap wealthi rest popul support redistribut polici tend low research test whether peopl toler inequ differ repres term success individu versus group peopl top econom ladder propos draw peopl attent wealthi individu undermin support redistribut lead peopl believ rich person wealth well deserv across eight studi n survey particip rate unequ distribut resourc fair present individu rather group top distribut particip also express lower support redistribut polici consid inequ repres success individu compar group effect driven peopl differ attribut individu versus group success particip thought individu top deserv success turn less like support redistribut inequ repres individu success find suggest support inequ polici reduc may depend peopl led consid think top econom distribut | D000078022;D012959 | T098;T078;T081;T080;T102 |
34,663,714 | brief case seri radiat associ myelopathi radiat myelopathi rm rare serious complic radiotherapi small vessel ischemia demyelin remark indic rm pathophysiolog rm diagnosi exclus differenti diagnosi infecti caus tumor rheumat diseas paraneoplast syndrom main diseas exclud contrast enhanc magnet reson imag mri use method diagnosi present report patient diagnos radiat myeliti patient present late paraparasia paresthesia despit high dose steroid hyperbar oxygen physic therapi clinic improv follow one year later | D009187;D011832;D013119 | T047;T037 |
34,663,713 | sjogren syndrom associ bilater peripher facial paralysi sjogren syndrom ss chronic autoimmun disord may complic neurolog dysfunct involv cranial nerv ss describ rare complic moreov bilater peripher facial paralysi associ ss describ patient literatur first case describ henrik sjogren report year old femal bilater peripher facial paralysi associ sjogren syndrom treat day ivig consecut continu oral methylprednisolon mgday almost fulli recov month follow examin acut bilater peripher facial palsi ss rare condit lyme diseas guillain barr syndrom hiv infect central nervous system lymphoma consid differenti diagnosi result ss consid under caus bilater facial paralysi | D005158;D020275;D015658;D012859 | T047;T184 |
34,663,712 | unusu present neurobrucellosi jeddah kingdom saudi arabia year old femal without histori medic psychiatr ill one month prior present clinic intermitt headach night sweat muscl pain went unnot week later patient develop agit behavior chang patient admit emerg room er psychiatri unit day detail interview neurolog clinic day post discharg describ previous mention symptom cerebrospin fluid analysi reveal leukocytosi normal protein glucos posit brucella titer blood receiv antibiot neurobrucellosi frequent follow up repeat spinal tap report normal symptom gradual improv neuropsychiatr manifest unusu present brucellosi case emphas import consid organ caus neurobrucellosi differenti diagnosi patient new onset unexplain neuropsychiatr symptom endem countri like kingdom saudi arabia | D000359;D002006 | T058;T047 |
34,663,711 | invas aspergillosi central nervous system immunocompet patient saudi arabia case seri review literatur invas aspergillosi central nervous system immunocompet patient rare diseas present studi three case treat centr review result similar studi saudi arabia | D001228 | T047 |
34,663,710 | deriv valid canp score model predict neurolog outcom post cardiac arrest patient establish valid prognost score model chines popul predict neurolog outcom among comatos survivor cardiac arrest ca | D016887;D006323 | T047;T061;T046 |
34,663,709 | preval depress among epilept patient taif citi saudi arabia assess depress relat differ factor among peopl epilepsi wider rang age | D003863;D004827 | T033;T048;T047;T184 |
34,663,708 | valproic acid children year age epilepsi evalu efficaci valproic acid vpa cohort children year age also aim review characterist patient role safeti vpa age group | D004827;D014635 | T033;T047;T121;T109 |
34,663,707 | investig inflamm relat gene polymorph mannos bind lectin schizophrenia bipolar disord investig associ mannos bind lectin mbl codon polymorph clinic featur patient diagnos schizophrenia scz bipolar disord bd | D001714;D037601;D012559 | T048;T121;T116 |
34,663,706 | public knowledg awar stroke among adult popul taif citi saudi arabia evalu knowledg awar stroke adult popul taif kingdom saudi arabia address associ sever sociodemograph variabl particip knowledg regard stroke | D007722;D020521 | T047;T053 |
34,663,705 | screen dysphagia relaps remit multipl sclerosi patient montenegro perform screen dysphagia montenegrin multipl sclerosi ms patient dysphagia often neglect problem patient ms | D003680;D009103;D020529 | T047 |
34,663,704 | polar depend cerebellar transcrani direct current stimul modul onlin function alert attent network investig modulatori effect anod cathod sham cerebellar transcrani direct current stimul ctdcs effici attent network name alert network orient network network execut control | D065908 | T061 |
34,663,703 | alter plasma glutam glutamin level patient drug resist drug respons symptomat focal epilepsi compar level plasma glutam glutamin drug resist drug respons symptomat focal epilepsi dysfunct glutam neurotransmiss play essenti role epilepsi pathophysiolog | D004828;D004364 | T047;T121 |
34,663,699 | special spinal circuit command amplif direct escap behavior vertebr action select often involv higher cognit entail evalu process howev urgent task defens escap requir immedi implement direct escap trajectori necessit local circuit reveal special spinal circuit execut escap direct adult zebrafish central compon circuit uniqu class segment repeat cholinerg va interneuron express transcript factor chx interneuron amplifi brainstem initi escap command rapid deliv excit via feedforward circuit fast motor neuron commissur interneuron direct escap maneuv inform transfer within circuit reli fast reliabl axo axon synapt connect bypass soma dendrit unilater ablat cholinerg va interneuron elimin escap command propag thus vertebr local spinal circuit implement direct urgent motor action vital surviv | D001522 | T053 |
34,663,698 | spatial transcriptom reveal role sensori nerv preserv cranial sutur patenc modul bmptgf signal pattern ossif mammalian skeleton requir coordin action intrins bone morphogen extrins neurovascular signal function tempor spatial fashion control mesenchym progenitor cell mpc fate show genet inhibit tropomyosin receptor kinas trka sensori nerv innerv develop cranium result prematur calvari sutur closur associ decreas sutur mpc prolifer increas miner vitro axon peripher affer neuron deriv dorsal root ganglion drgs wild type mice induc mpc prolifer spatial restrict manner via solubl factor cocultur microfluid chamber compar spatial transcriptom analysi cranial sutur vivo confirm posit associ sensori axon prolif mpcs spatialtim analysi across develop sutur reveal region specif alter bone morphogenet protein bmp tgf signal pathway transcript respons trka inhibit rna sequenc drg cell bodi follow direct axon cocultur mpcs confirm alter bmptgf signal pathway transcript among bmp inhibitor follistatin like fstl replic key featur neural bone influenc includ mitogen anti osteogen effect via inhibit bmptgf signal taken togeth result demonstr sensori nerv deriv signal includ fstl function coordin cranial bone pattern regul mpc prolifer differenti sutur mesenchym | D015398;D059467 | T043;T044;T086;T081 |
34,663,697 | train innat immun long last epigenet modul skew myelopoiesi heme train immun defin long last adapt innat immun base transcript epigenet modif myeloid cell bone marrow progenitor divangahi et al nat immunol innat immun cell howev exclus differenti foreign self also react host deriv molecul refer alarmin extracellular labil heme releas infect bona fide alarmin promot myeloid cell activ p soar bozza curr opin immunol report labil heme previous unrecogn induc train immun confer long term regul lineag specif hematopoiet stem cell progenitor cell contrast previous report train immun essenti mediat pathogen associ molecular pattern heme train depend spleen tyrosin kinas signal transduct pathway act upstream c jun n termin kinas heme train promot resist sepsi associ expans self renew hematopoet stem cell prime toward myelopoiesi occurr specif myeloid cell popul potenti evok sustain activ nfix runx nfel dissoci transcript repressor bach previous report train immun induc howev infrequ present host wherea heme abund occur noninfecti infecti diseas differ might explain vanish protect exert heme train sepsi time sustain long term myeloid adapt henc propos train immun integr compon innat immun distinct function differ infecti diseas outcom depend induct pathogen endogen molecul | D044127;D007113;D038042 | T032;T042;T045 |
34,663,696 | risk factor hiv infect among men sex men anr ipergay prep trial aim assess among men sex men msm risk factor hiv infect identifi requir urgent pre exposur prophylaxi prep prescript | D019380;D015658;D013287;D065129;D000072339 | T047;T121;T109;T098;T131;T061 |
34,663,695 | mnemon predict error promot detail memori experi violat predict adapt updat knowledg promot accur represent world facilit futur predict theoret model propos mnemon predict error encod distinct memori trace prevent interfer previous conflict memori investig propos repeat expos particip pair sequenti present object b thus evok expect violat particip expect replac second object pair novel object c follow item memori test requir particip discrimin ident old item similar lure thus test detail distinct item memori represent two experi mnemon predict error enhanc item memori particip correct identifi old item old item violat expect learn compar item violat expect memori enhanc c item observ particip later show intact memori relat b pair suggest strong predict requir facilit memori violat follow third experi reduc predict strength prior violat subsequ elimin memori advantag violat interest mnemon predict error increas gist base mistak identifi old item similar lure identifi similar lure old enhanc item memori absenc gist base mistak suggest violat enhanc memori item detail could mediat via distinct memori trace togeth result advanc knowledg mnemon predict error promot memori format | D007858;D008568 | T061;T062;T041 |
34,663,694 | development emerg persist memori contextu auditori fear mice abil generat memori persist throughout lifetim memori persist emerg earli develop across speci although shown persist fear memori emerg late infanc adolesc mice unclear exact transit take place whether two major fear condit task contextu auditori fear share time line development onset compar ontogeni remot contextu auditori fear cblj mice across earli life mice postnat day p underw either contextu auditori fear train test fear retriev later found mice display memori context tone fear start p find sex differ ontogeni either type fear memori furthermor contextu fear retriev led increas number c fos posit cell prelimb region prefront cortex age contextu fear memori success retriev data delin precis time line emerg persist contextu auditori fear memori mice suggest prelimb cortex recruit remot memori recal upon onset memori persist | D005239;D008568 | T041 |
34,663,693 | distribut learn episod creat context fear memori outsid hippocampus depend perirhin anterior cingul cortic damag hippocampus hpc typic caus retrograd amnesia contextu fear condit repeat condit sever session howev elimin retrograd amnes effect form reinstat thus permit modif network support context memori retriev absenc hpc present studi aim identifi cortic region support nonhpc context memori specif contribut perirhin cortex prh anterior cingul cortex acc examin establish import context memori find show context memori establish distribut reinstat surviv damag limit hpc prh acc combin lesion hpc prh well hpc acc caus retrograd amnesia suggest network modif prh acc enabl context fear memori becom resist hpc damag | D005239;D006179 | T023;T029;T041 |
34,663,692 | multistag retriev account associ recognit roc curv despit name associ recognit paradigm thought reli memori recal howev remain unclear associ inform may repres retriev memori relationship inform item memori propos comput model associ recognit relat inform access generic multistag retriev process model explain relat difficulti associ recognit compar item recognit differ experiment outcom differ type lure use well condit lead emerg associ roc curv differ shape | D008568;D021641 | T041 |
34,663,691 | pterosaur evolv muscular wing bodi junction provid multifacet flight perform benefit advanc aerodynam smooth sophist wing root control wing forc generat pterosaur first vertebr flyer live million year howev aspect flight anatomi flight perform remain unclear use laser stimul fluoresc observ direct soft tissu evid wing root fair pterosaur featur smooth wing bodi junction reduc associ drag modern aircraft fli anim unlik bat bird pterosaur wing root fair uniqu primarili made muscl rather fur feather muscular featur pterosaur appear use fair access flight perform benefit sophist control wing root contribut wing elev andor anterior wing motion flight stroke studi underscor valu use new instrument fill knowledg gap pterosaur flight anatomi evolut | D005075 | T045 |
34,663,690 | hervh deriv lncrnas negat regul chromatin target remodel mediat chd chd encod atp depend chromatin remodel shown target specif genom loci alter local transcript potenti remodel chromatin structur de novo mutat chd major caus charg syndrom featur multipl development defect examin whether nuclear rnas might contribut target function identifi preferenti interact chd lncrnas deriv hervh loci pluripot stem cell knockdown hervh famili lncrnas use lnas knockout individu copi hervh crispr cas result increas bind chd increas level hkac subset enhanc deplet hervh famili rnas led activ multipl gene chd bound hervh rna high affin low specif interact decreas abil chd bind remodel nucleosom present model hervh lncrnas act decoy modul dynam chd bind enhanc pluripot cell activ numer gene might impact differenti process | D042002;D005786;D062085;D012367 | T114;T045;T123 |
34,663,688 | pharmacolog modul immun respons nutrit compon incid noncommunic diseas ncds increas last decad one major contributor lifestyl especi diet high intak satur fatti acid low intak dietari fiber link increas ncds convers low intak satur fatti acid high intak dietari fiber seem protect effect general health sever mechan identifi underli phenomenon review focus pharmacolog receptor includ aryl hydrocarbon receptor bind partner retinoid x receptor g coupl protein receptor toll like receptor activ nutrit compon metabolit depend nutrit compon receptor involv proinflammatori anti inflammatori effect occur lead alter immun respons insight may provid opportun prevent treatment ncds inher sub chronic inflamm signific statement review summar report effect nutrit compon metabolit immun system manipul specif pharmacolog receptor includ aryl hydrocarbon receptor bind partner retinoid x receptor g coupl protein receptor toll like receptor nutrit compon vitamin fiber unsatur fatti acid abl resolv inflamm wherea satur fatti acid tend exhibit proinflammatori effect may aid decis maker scientist develop strategi decreas incid noncommunic diseas | D007109;D007249 | T046;T042 |
34,663,687 | g protein kinas pka pathway signalopathi emerg genet landscap therapeut potenti human diseas driven aberr g pka signal mani fundament concept signal transduct kinas activ attribut discoveri crystal camp depend protein kinas protein kinas pka one best studi kinas human biolog emphasi biochemistri biophys way metabol hormon action gene express regul surpris howev understand pka role diseas larg underappreci although genet mutat pka holoenzym known caus diseas carney complex cush syndrom acrodysostosi stori larg stop recent explos genom medicin final appreci broader role g pka pathway diseas contribut aberr function g protein g protein coupl receptor well multipl alter pathway compon negat regul togeth repres broad famili diseas term g pka pathway signalopathi g pka pathway signalopathi encompass diseas caus germlin postzygot somat mutat g pka pathway larg endocrin neoplast phenotyp present signal centric review g pka driven pathophysiolog integr comput structur analysi identifi mutat theme common exploit g pka pathway signalopathi major mutat theme includ hotspot activ mutat gs encod gnas mutat destabil pka holoenzym review hope incit studi ultim develop new therapeut strategi treatment wide rang human diseas signific statement littl recognit given causat role g pka pathway dysregul diseas effect rang infecti diseas endocrin syndrom mani cancer yet dispar diseas understood common genet theme biochem signal connect highlight common pathogen mechan bridg multipl disciplin import progress made toward therapeut advanc treat g pka pathway driven diseas | D017868;D000088744 | T091;T116;T126 |
34,663,686 | l type calcium channel blocker potenti novel therapeut approach drug depend review describ interact compound primarili dihydropyridin block l type calcium channel drug caus depend potenti import interact main depend induc drug cover alcohol psychostimul opioid nicotin preclin studi l type calcium channel blocker prevent reduc import compon depend drug particular reinforc action withdraw syndrom channel blocker also reduc develop toler andor sensit intrins depend liabil instanc effect includ revers brain chang establish drug depend prolong treatment alcohol opioid psychostimul drug nicotin caus upregul dihydropyridin bind site clinic studi carri far report conflict although evid effect l channel blocker opioid withdraw howev dose l type channel blocker use clinic far necessarili limit potenti cardiovascular problem may provid suffici central level drug affect neuron dihydropyridin bind site new l type calcium channel block compound develop select action subtyp l channel preclin evid suggest l type calcium channel may play crucial role develop depend differ type drug mechan propos includ chang activ mesolimb dopamin neuron genom effect alter synapt plastic newli develop select l type calcium channel blocker could consider valu treatment drug depend signific statement depend drug serious health problem littl effect treatment preclin evid show drug block particular calcium channel l type reduc depend relat effect alcohol opioid psychostimul nicotin clinic studi restrict potenti cardiovascular side effect new select l channel blocker becom avail l channel blocker intrins depend liabil laboratori evid suggest revers previous develop effect depend induc drug could provid novel approach addict treatment | D002121;D019966 | T033;T048;T121 |
34,663,685 | analges potenti terpen deriv cannabi sativa pain preval among adult unit state increas past two decad result high health care cost impact patient qualiti life last year understand pain circuit intra cellular mechan grown exponenti understand yet result improv therapi option pain manag limit mani analges poor efficaci accompani sever side effect addict result devast opioid abus overdos epidem problem encourag scientist identifi novel molecular target develop altern pain therapeut increas preclin clinic evid suggest cannabi sever benefici pharmacolog activ includ pain relief cannabi sativa contain chemic compound two principl phytocannabinoid tetrahydrocannabinol thc cannabidiol cbd beyond phytocannabinoid terpen identifi differ cannabi chemovar although predomin cannabinoid thc cbd thought primari medicin compound terpen includ monoterpen myrcen pinen limonen linalool well sesquiterpen caryophyllen humulen may contribut mani pharmacolog properti cannabi includ anti inflammatori antinocicept effect aim review summar current knowledg terpen compound cannabi analyz avail scientif evid role cannabi deriv terpen modern pain manag signific statement decad research improv knowledg cannabi polypharmaci contribut phytochem includ terpen reform legal status cannabi possess increas avail medicin recreat result cannabi use combat increas preval pain may help address opioid crisi better understand pharmacolog effect cannabi activ compon includ terpen may assist identifi new therapeut approach optim use cannabi andor terpen analges agent | D002186;D002188 | T167;T121;T002;T109 |
34,663,684 | parkinson diseas translat insight molecular mechan neuroprotect parkinson diseas pd use consid nongenet condit howev identif sever autosom domin recess mutat link monogen pd chang view clinic manifest pd thought occur complex interplay genet mutat mani incomplet penetr environment factor neuroprotect increas suscept variabl interact reach threshold pd becom clinic manifest function studi pd gene product identifi mani cellular molecular pathway provid crucial insight natur caus pd pd origin multipl caus rang pathogen process play ultim culmin nigral dopaminerg loss motor dysfunct depth understand complex possibl converg pathway pave way therapeut approach allevi diseas symptom neuroprotect strategi prevent diseas manifest review aim provid comprehens understand advanc made pd research base leverag genet insight pathogenesi pd discuss novel perspect facilit identif critic molecular pathway central neurodegener hold potenti develop neuroprotect andor neurorestor therapeut strategi pd signific statement comprehens review pd pathophysiolog provid complex interplay genet environment factor biolog process contribut pd pathogenesi knowledg identifi new target could leverag diseas modifi therapi prevent slow neurodegener pd | D010300 | T047 |
34,663,683 | brain cancer drug discoveri clinic trial drug class target combinatori therapi brain cancer formid challeng drug develop drug deriv mani cut edg technolog test clinic trial manual character clinic trial brain tumor regist clinicaltrialsgov identifi uniqu therapeut entiti target uniqu drug target uniqu treatment combin involv drug perform classif drug drug target base pharmacolog structur classif analysi demonstr larg divers agent target current identifi differ pharmacolog direct therapi base structur class agent analysi show kinas inhibitor chemotherapeut agent cancer vaccin three common class agent identifi trial agent clinic trial demonstr uneven distribut combin approach chemotherapi agent proteasom inhibitor immun modul frequent appear combin wherea kinas inhibitor modifi immun effector cell shown combin network descript statist analysi provid extens overview drug discoveri field brain cancer shift happen recent year challeng like come signific statement review provid comprehens quantit analysi discuss brain cancer drug discoveri field includ classif drug target therapi | D000970;D001932;D004364 | T191;T121;T109 |
34,663,681 | exercis intervent academ achiev among children random control trial physic inact import health concern worldwid studi examin effect exercis intervent children academ achiev cognit function physic fit health relat outcom | D000076363;D003071;D010809 | T080;T041;T078 |
34,663,680 | state spend public benefit program child maltreat determin associ state total spend benefit program child maltreat outcom | D000077108 | T064 |
34,663,674 | neuromyel optica spectrum disord africa systemat review neuromyel optica nmo cns inflammatori diseas predomin affect optic nerv spinal cord frequent asian african popul european one data epidemiolog clinic present addit investig treatment african contin scarc aim collect analyz publish data neuromyel optica spectrum disord nmosd indic challeng diagnosi manag discuss opportun futur research educ polici make specif african contin | D009471 | T047 |
34,663,673 | facilit barrier implement alberta famili integr care ficar level ii neonat intens care unit qualit process evalu substudi multicentr cluster randomis control trial use consolid framework implement research evalu barrier facilit implement alberta famili integr care ab ficar benzi model care integr parent level ii neonat intens care unit nicus care team perspect healthcar provid hcp hospit administr | D019033;D007363 | T058;T093;T073 |
34,663,672 | potenti effect cardiometabol risk factor bodi composit short messag servic sms guid train recent minor stroke transient ischaem attack post hoc analys strokewalk randomis control trial evalu effect mobil phone text messag exercis instruct bodi composit cardiometabol risk marker self report health month stroke | D002546;D020521;D060145 | T170;T052;T047;T066 |
34,663,671 | cross section studi parent knowledg behaviour anxieti manag paediatr fever among german parent fever common symptom among children parent lack knowledg fever could caus anxieti lead unnecessari measur subsid fever littl evid german parent knowledg fever manag | D058633;D010290 | T039;T102;T121;T099 |
34,663,670 | explor linkag climat chang sexual health scope review protocol effect climat chang associ extrem weather event ewe present substanti threat well ewe hold potenti harm sexual health pathway includ elev exposur hiv sexual transmit infect stis disrupt healthcar access increas sexual gender base violenc sgbv defin four compon sexual health comprehens sexual educ hiv sti prevent care sgbv prevent care psychosexu counsel yet knowledg gap remain regard climat chang associ sexual health domain scope review therefor explor linkag climat chang sexual health | D015658;D000074384;D012749 | T032;T047 |
34,663,669 | assess predict adolesc earli adulthood common mental disord use electron primari care data analysi prospect cohort studi alspac southwest england aim examin agreement common mental disord cmds primari care record repeat cmd questionnair data alspac avon longitudin studi parent children adolesc young adulthood explor factor affect cmd identif primari care record construct model predict alspac deriv cmds use primari care data | D001523 | T048 |
34,663,668 | advanc mechan implement acceler sustain evid base practic integr protocol generat research agenda mechan explain implement strategi work implement research requir care operationalis empir studi causal pathway strategi effect chang factor may amplifi weaken effect understand mechan critic import replic find learn negat studi adapt implement strategi develop one set anoth without understand implement mechan difficult design strategi produc expect effect across context may disproportion effect set prioriti popul receiv care manuscript outlin protocol agenc healthcar research qualiti fund initi establish prioriti agenda guid research implement mechan health public health dissemin agenda research polici practic audienc | D055317;D006302 | T091;T062;T169 |
34,663,667 | barrier facilit access health social care servic peopl live homeless hostel qualit studi experi hostel staff resid uk hostel number peopl live homeless hostel uk steadili increas past decad despit peopl experienc homeless often consider health problem rang complex need frequent associ addict experi hostel staff resid especi relat access health social care support seldom explor aim paper identifi barrier facilit access health social care servic peopl live homeless hostel | D006703 | T095;T033;T098 |
34,663,666 | relationship serum uric acid caus mortal cardiovascular mortal periton dialysi patient systemat review meta analysi cohort studi analys relationship serum uric acid sua caus cardiovascular cv mortal periton dialysi pd patient inform clinic practic futur research | D002318;D010530 | T047;T061 |
34,663,665 | two field non mydriat fundus photographi diabet retinopathi screen protocol systemat review meta analysi diabet retinopathi dr one preval microvascular complic diabet mellitus guidelin dr screen differ countri vari great includ fundus photographi slit lamp biomicroscopi indirect ophthalmoscopi optic coher tomographi oct oct fundus fluorescein angiographi ffa two field non mydriat fundus photographi nmfp effect screen method due low cost less time consum process howev controversi due sensit specif two field nmfp review intend evalu perform two field nmfp diagnos dr help clinician determin optim screen method | D003920;D003930 | T047 |
34,663,664 | sar cov seropreval healthcar worker teach hospit high endem region netherland first wave cross section studi studi sar cov infect rate among hospit healthcar worker first wave covid pandem provid knowledg understand relationship infect symptomatolog sourc infect | D000086382;D000086402 | T047;T005;T067 |
34,663,663 | impact covid restrict preschool children eat activ sleep behaviour qualit studi spring first covid nation lockdown place unpreced restrict behaviour movement uk popul citizen order stay home allow leav hous buy essenti suppli attend medic appoint exercis day explor lockdown subsequ eas chang young children everyday activ eat sleep habit gain insight impact health well | D000086382 | T047;T067 |
34,663,662 | characterist frequent attend children hospit emerg depart systemat review summaris literatur frequent attend hospit emerg depart ed describ sociodemograph clinic characterist children attend ed frequent | D004636;D011320 | T058;T093;T073 |
34,663,661 | knowledg percept practic pharmacist regard generic substitut china cross section studi evalu pharmacist knowledg percept practic toward generic substitut pilot locat china | D057915;D010595 | T058;T097 |
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