PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,661,737 | hypotens cathet ablat year old femal patient symptomat atrial tachycardia develop cold sweat hypotens recoveri room pulmonari vein isol procedur includ anterior line endo epicardi mitral isthmus line echocardiographi exclud hemodynam relev pericardi effus patient symptom deterior time rare caus found | D001281;D017115;D007022;D011667 | T023;T047;T046;T061;T033 |
34,661,736 | clinic find eye best relat retinopathi complic choroid neovascular determin characterist eye diagnos best vitelliform macular dystrophi bvmd autosom recess bestrophinopathi arb complic choroid neovascular cnv | D000075002;D020256;D012164;D057826 | T047;T116;T046;T123 |
34,661,735 | associ staf incid delay retin break detach posterior vitreous detach resid urgent care clinic compar incid rate delay retin break detach diagnosi acut symptomat posterior vitreous detach pvd resid run urgent care clinic ucc staf retina attend non retina ophthalmolog attend optometrist ophthalmolog resid | D012163;D012167;D020255 | T047 |
34,661,734 | current practic trend lacrim gland neurotoxin manag epiphora bopss survey inject botulinum neurotoxin bonta lacrim gland lg offer simpl effect treatment manag epiphora howev littl data current practic trend uptak altern surgeri studi assess current practic trend treatment amongst bopss british oculoplast surgeri societi member | D019274;D007765;D007766 | T116;T023;T121;T047;T109;T129;T131;T030 |
34,661,732 | zone wise examin optic coher tomographi featur correspond multifoc electroretinographi eye nonprolif diabet retinopathi examin retin structur optic coher tomographi oct function mean multifoc electroretinographi mferg eye without nonprolif diabet retinopathi npdr correspond local retin function oct zone retin lesion | D003920;D003930;D012162 | T047;T046 |
34,661,731 | tempor variat optic coher tomographi biomark predictor anti vegf treatment outcom diabet macular edema report longitudin analysi specif optic coher tomographi oct featur eye diabet macular edema dme treat anti vegf | D003920;D003930;D008269 | T047 |
34,661,730 | dna barcod rumen fluke paramphistomida bovin germani austria rumen fluke receiv grow veterinari attent western central europ past two decad increas preval infect cattl sheep includ case sever clinic diseas histor rumen fluke infect europ assum caus main paramphistomum cervi speci later consid synonym p cervi recent molecular studi demonstr calicophoron daubneyi predomin speci present investig adult rumen fluke isol cattl origin ten farm germani saxoni baden wrttemberg bavaria one farm austria tyrol analyz establish partial sequenc mitochondri cytochrom c oxidas subunit coi complet sequenc nuclear intern transcrib spacer fluke five anim dairi cow three farm bavaria determin p leydeni fluke anim dairi cow cattl cow calf oper eight farm saxoni baden wrttemberg bavaria tyrol identifi c daubneyi base molecular analysi adult rumen fluke collect cattl result investig confirm common occurr c daubneyi germani reveal first definit find p leydeni germani c daubneyi austria | D002418;D010250;D014200;D014201 | T204;T047 |
34,661,729 | hemodynam impact atrial pace patient fontan physiolog junction rhythm cardiac catheter studi sinus node dysfunct common problem advers impact patient undergon fontan oper fontan patient adequ junction escap rhythm benefit atrial pace restor atrioventricular synchroni remain unclear data collect retrospect fontan patient junction rhythm underw atrial pace cardiac catheter hemodynam obtain baselin atrial pace min seven patient mean age year studi type fontan extracardiac later tunnel one patient pace bpm faster junction rate pace signific decreas left atrial pressur mean sem mmhg p signific increas cardiac index lminm p pulmonari blood flow lminm p signific chang pulmonari arteri pressur mmhg p pulmonari vascular resist wu p fontan patient junction rhythm atrial pace decreas left atrial pressur increas cardiac output signific chang pulmonari arteri pressur studi support investig util prophylact atrial pacemak implant fontan patient signific durat jr ambulatori monitor | D018729 | T042;T061 |
34,661,727 | percept use opioid covid survey member german associ palliat medicin opioid effici allevi pain dyspnea howev guidelin symptom manag opioid differ may lead uncertainti concern opioid indic ethic implic among medic staff especi care covid patient | D000086382;D065126 | T091;T047;T067 |
34,661,723 | effect covid schoolteach emot reaction mental health longitudin result class studi investig schoolteach emot reaction covid mental health three phase covid pandem analyz teacher belong covid risk group emot reaction poorer mental health non risk group | D000086382;D008603 | T047;T041;T067 |
34,661,722 | associ recognit work subsequ health qualiti life among older work adult recognit work act convey non financi appreci outstand accomplish perform top motiv employe perform import contributor psycholog healthi work employe recognit program offer mani compani shown retain top talent increas job satisfact perform yet evid role receiv employe recognit health qualiti life remain limit studi examin whether receiv recognit work prospect associ six indic health qualiti life loneli | D006973;D011788 | T047;T078 |
34,661,721 | migrant worker occup health research omega net work group posit paper aim studi clarifi definit migrant use occup health research summar migrant worker industri sector occup employ condit identifi occup health safeti servic avail migrant worker summar work relat health problem found among migrant worker identifi methodolog challeng research occup health migrant worker recommend improv migrant occup health research | D000086382;D016272;D014171 | T047;T098;T091;T067;T078 |
34,661,720 | absente associ labour cost accord depress symptom sever german general popul prevent strategi matter depress high preval mental health condit substanti individu societ econom consequ studi focuss associ depress symptom sever absente durat employ labour cost | D000041;D003863 | T048;T184;T055 |
34,661,719 | target psdnnos zl allevi social isol induc heighten attack behavior mice deregul attack behavior devast social consequ howev satisfactori clinic manag behavior still unmet need far social isol si common covid pandem may detriment effect mental health includ elicit heighten attack behavior | D000374;D012934 | T054;T055 |
34,661,718 | hydroxyurea load fe sio chitosan g mpeg nanoparticl ph depend drug releas evalu cell cycl arrest alter p lincrna p gene express carbohydr polym wide use pharmaceut drug deliveri system due biodegrad biocompat among chitosan cs consid mani new drug deliveri system poli ethylen glycol hydrophil polym increas solubl stealth function nanocarri fe nanoparticl function polym act non toxic drug vehicl tumor target extern magnet field present studi fe sio nh nanoparticl prepar function methoxi pegyl chitosan cs g mpeg hydroxyurea hu load nanoparticl structur crystallin morpholog hufe sio cs g mpeg determin use spectroscop electron microscopi analysi encapsul effici hu percentag load releas rate differ ph valu c examin maximum drug releas observ ph accord tem result nanoparticl size nm cytotox effect hu load nanoparticl mcf human breast cancer cell evalu use mtt assay cell cycl arrest analysi inhibitori concentr ic valu gml mcf cell line compar control group h h respect addit express p lincrna p gene treat cell control group assess use real time pcr result show ratio p express lincrna p mcf cell signific increas p cell cycl arrest phase popul cell increas fold compar control group | D016503;D053758 | T074;T073 |
34,661,717 | remot triag urgent suspect head neck cancer referr experi first wave covid pandem respons coronavirus diseas covid pandem otolaryngolog depart across unit kingdom adopt non face face clinic consult carri remot via telephon video call reduc footfal hospit site aim strategi limit direct contact curb spread infect report outlin experi conduct telephon triag clinic assess urgent suspect head neck cancer referr first wave covid pandem | D000086382;D006258;D019114 | T191;T047;T060;T067 |
34,661,716 | hpv status therapeut initi strategi impact surviv oncolog outcom year result multicentr prospect cohort oropharyng cancer papillophar year follow aim evalu year impact human papillomavirus hpv status tobacco initi treatment approach progress free surviv pfs overal surviv os patient oropharyng cancer opc franc | D052685;D009959;D030361 | T191;T047;T005 |
34,661,715 | tranexam acid head neck procedur systemat review meta analysi random control trial conduct meta analysi random control trial rcts examin benefit tranexam acid txa among cancer patient undergo head neck h n procedur | D000933;D014148 | T121;T109 |
34,661,709 | dendrit cell therapi cdl dc ebv vax local recurr metastat nasopharyng carcinoma safe confer clinic benefit epstein barr virus ebv associ nasopharyng carcinoma npc provid target dendrit cell dc vaccin cd ligand cdl express antigen present cell costimul cd express cell revers cdl signal differenti monocyt cdl dc type dc potent classic dc stimul cell | D020031;D009303 | T191;T047 |
34,661,708 | enhanc biotransform ginsenosid white ginseng root aerob co cultiv bacillus subtili trichoderma reesei present work biotransform ginsenosid white ginseng root innov investig use aerob ferment co cultiv bacillus subtili trichoderma reesei found co cultiv mode optim nitrogen sourc corn steep liquor load ginseng powder inocul proport b subtili reesei gl respect total ginsenosid yield product minor ginsenosid co cultiv mode obvious enhanc comparison monocultur mode meanwhil maxim total ginsenosid yield high hydrolas activ achiev use stage inocul inocul proport co cultiv mode product minor ginsenosid rg rh rh signific strengthen pharmacolog activ ferment solut obvious improv enhanc ginsenosid transform main attribut hydrolysi produc hydrolas metabol two probiot result clear reveal use stage inocul co cultiv ferment mode favor ginsenosid biotransform ginseng due non synchron cell growth differ metabol pathway probiot work provid novel method enhanc ginsenosid transform ginsengkey point co cultiv ferment signific promot ginsenosid biotransform stage inocul co cultur mode optim oper method pharmacolog activ co cultur solut signific enhanc | D036145;D005894;D014242 | T004;T121;T002;T109 |
34,661,707 | hyaluron acid product transcript regul transcript repressor gene delet studi streptococcus zooepidemicus hyaluron acid ha multipl function biopolym wide use food cosmet biomed field group c streptococci major workhors ha product industri ha biosynthet pathway propos ha synthesi regul unclear studi identifi twenti five putat transcript repressor zooepidemicus studi whether regul ha synthesi individu gene delet strain first construct phenotyp chang correspond delet strain stress toler ha product detect hrca delet strain sensit high temperatur rex delet strain resist oxid stress three transcript repressor delet result signific decreas transcript level hasa among scrr delet strain show dramat decreas ha product regulatori mechan scrr affect product ha explor transcript express analysi scra scrb two direct target gene scrr regulon result indic defici scrr result unbalanc express scra scrb might also part account decreas product ha agreement specul overexpress scrb scrr genet background result improv ha product taken togeth system genet studi transcript repressor expand understand physiolog regul process zooepidemicus help develop high perform industri strain effici product ha key point twenti two transcript repressor gene zooepidemicus delet individu phenotyp correspond mutant varieti condit character hrca defici show inferior cell toler high temperatur rex defici show superior cell toler reactiv oxygen stress four repressor defici show inferior hyaluron acid synthesi among transcript level hasa three mutant decreas signific optim sucros metabol flux enhanc hyaluron acid synthesi signific | D018502 | T007 |
34,661,706 | metabol engin yarrowia lipolytica dual biocatalyt system produc fatti acid ethyl ester renew feedstock situ one pot given grave concern increas consumpt petroleum resourc dramat environment chang aris carbon dioxid emiss worldwid microbi biosynthesi fatti acid ethyl ester faee biofuel renew sustain replac petroleum base fuel attract much attent one import microbi chassi nonconvent oleagin yeast yarrowia lipolytica emerg paradigm organ product sever advanc biofuel chemic report engin lipolytica use effici dual biocatalyt system situ one pot product faee renew feedstock compar glucos ww convers rate faee sunflow seed oil cultur medium effici use generat faee ww convers rate faee engin lipolytica strain gqi demonstr optim intercellular heterolog faee synthesi pathway particular titer extracellular faee sunflow seed oil reach gl fold higher glucos carbon sourc effici dual biocatalyt system combin ex vivo strengthen vitro faee product rout construct overexpress lipas lip variant background strain gqi increas faee level gl notabl delet ethanol metabol pathway minim impact faee product final wast cook oil low cost oil base substanc use carbon sourc faee product lipolytica dual biocatalyt system result product gl faee thus develop system repres promis green sustain process effici biodiesel product key point faee produc engin yarrowia lipolytica lip variant overexpress yeast creat dual biocatalyt system wast cook oil substrat result high titer gl faee | D025062 | T004 |
34,661,705 | sugar organ acid avail modul soil diazotroph communiti assembl speci co occurr pattern tibetan plateau metabolit mediat speci interact assembl microbi communiti howev chemic relat assembl process co occurr pattern diazotroph assemblag root associ soil remain larg unknown examin divers assembl diazotroph communiti deciph link metabolit tibetan plateau found distribut sugar organ acid root associ soil signific correl rich diazotroph presenc two soil metabolit explain variabl diazotroph communiti composit differenti concentr metabolit signific link distinct abund diazotroph taxa land type domin differ plant dissimilar soil plant assembl diazotroph communiti subject determinist ecolog process wide modul varieti amount sugar organ acid organ acid instanc hydroxyphenyl propion acid citric acid effect predictor characterist diazotroph assemblag across desert habitat diazotroph co occurr network tend complex connect within differ land type cover plant speci concentr multipl sugar organ acid coupl signific distribut keyston speci azotobact azospirillum bradyrhizobium mesorhizobium co occurr network find provid new insight assembl mechan root associ diazotroph communiti across desert ecosystem tibetan plateaukey point soil metabolit signific link divers diazotroph communiti soil metabolit determin assembl diazotroph communiti sugar organ acid coupl main keyston speci network | D064307;D012987 | T167;T032;T001;T028 |
34,661,704 | minim invas arthrodesi sacroiliac joint sij pain reduct improv qualiti life sacroiliac joint sij fusion | D017116;D013123 | T047;T184;T061 |
34,661,701 | prognost impact indic system inflamm nutrit status patient resect carcinoma ampulla vater singl center retrospect studi sever indic system inflamm nutrit status recent shown serv novel prognost factor certain cancer aim investig prognost impact preoper indic system inflamm nutrit status associ surviv patient resect ampulla vater carcinoma ac | D014670;D002277 | T191;T023 |
34,661,700 | umezawaea beigongshangensi sp nov isol mash baijiu gram posit aerob non motil actinobacteri strain design ren isol mash baijiu chines spirit kind distil liquor made cook saccharif ferment distil collect sichuan provinc region china character use polyphas approach morpholog chemotaxonom properti strain ren consist descript genus umezawaea spore arrang abund aerial mycelium fragment substrat mycelium diamino acid peptidoglycan meso diaminopimel acid diagnost phospholipid dpg diphosphatidylglycerol pg phosphatidylglycerol pi phosphatidylinositol pe phosphatidylethanolamin major fatti acid c c iso c iso c h c c c c menaquinon mk h predomin menaquinon genom dna g c content mol phylogenet analysi base rdna gene sequenc demonstr strain ren also classifi genus umezawaea u tangerina u endophytica howev distinguish closest strain u tangerina jcm base low level dna dna hybrid base upon morpholog physiolog chemotaxonom molecular characterist differ member genus novel speci umezawaea beigongshangensi sp nov propos ren jcm cgmcc type strain | D005227;D010743 | T168;T109;T123 |
34,661,699 | incid risk factor pre oper deep venous thrombosi geriatr intertrochanter fractur patient purpos prospect studi investig pre oper incid risk factor deep venous thrombosi dvt geriatr intertrochanter fractur help facilit peri oper manag | D006620;D020246 | T047;T037;T046 |
34,661,698 | autom subcort volum estim mri epilepsi implic clinic trial techniqu use automat segment subcort brain region develop three dimension mr imag mris obtain non specialist hospit may non isotrop two dimension automat segment imag may challeng repres lost opportun perform quantit imag analysi determin perform modifi subcort segment techniqu appli imag patient idiopath generalis epilepsi ige | D004827;D008279 | T047;T170;T060;T033;T059 |
34,661,697 | genom wide analysi delet maiz popul reveal abund genet divers function impact two read depth method joint use next generat sequenc data identifi delet maiz popul gwas delet analyz gene express pattern classic trait respect mani studi confirm structur variat sv pervas throughout maiz genom delet one type sv may impact gene express caus phenotyp chang quantit trait studi two read count approach use analyz delet whole genom sequenc data maiz inbr line total delet window overlap gene uneven distribut across genom delet explain popul structur well correl genom featur delet proport gene determin negat correl express detect gene express quantit trait loci eqtl indic local eqtl fewer larger effect distant one common associ gene relat basic metabol process wherea uniqu associ gene eqtl play role stress stimulus respons multipl tissu compar eqtl detect snps deriv sequenc data associ gene could detect marker effect top eqtl detect snps usual larger detect delet gene genom wide associ studi gwas flower time plant height illustr loci could consist captur snps suggest combin delet snp gwas excel strategi dissect trait architectur find provid insight characterist biolog function genom wide delet maiz | D017353;D014644;D018745 | T070;T028;T045 |
34,661,696 | character fine map lesion mimic mutant lm enhanc stripe rust powderi mildew resist bread wheat triticum aestivum l novel light intens depend lesion mimic mutant enhanc diseas resist physiolog biochem genet character causat gene fine map mbp interv contain high confid gene lesion mimic mutant ideal studi diseas resist program cell death photosynthesi plant improv crop yield studi novel light intens depend lesion mimic mutant mc obtain wheat varieti chuannong cn ethyl methan sulfon treatment mutant initi develop tini lesion spot basal part leav gradual proceed leaf sheath stem shell awn flower stage major agronom trait signific alter mutant compar wild type cn furthermor mutant exhibit lesion phenotyp degener chloroplast structur decreas chlorophyl content increas level reactiv oxygen speci increas resist stripe rust powderi mildew genet analysi indic lesion phenotyp control novel singl semi domin nuclear gene target gene map chromosom arm al locat kompetit allel specif pcr kasp marker kasp kasp tentat term lesion mimic lm fine map suggest lm locat mbp interv marker kasp kasp high confid candid gene includ genom region studi provid import foundat step clone lm use map base approach | D001487;D014908 | T004;T002;T168 |
34,661,695 | genom wide associ map genom predict yield relat trait starch past properti cassava gwas identifi eight yield relat peak starch type waxi wild type starch starch past properti relat trait qtls predict abil eight gs model result low high predict depend trait herit genet architectur cassava food industri crop africa south america asia knowledg gene control yield starch past properti remain limit carri genom wide associ studi clarifi molecular mechan under trait explor marker base breed approach estim predict abil genom select gs use parametr semi parametr nonparametr gs model panel cassava genotyp thai tapioca develop institut intern center tropic agricultur intern institut tropic agricultur breed program cassava panel genotyp via genotyp sequenc singl nucleotid polymorph snp marker identifi total snps associ yield starch type starch properti trait detect fix random model circul probabl unif farmcpu bayesian inform linkag disequilibrium iter nest keyway compress mix linear model respect gs model develop forward predict use predict method result valu four yield relat trait seven starch past properti trait studi provid addit insight genet architectur import trait develop marker could use cassava breed program | D032461;D018745;D000069600 | T040;T026;T028 |
34,661,694 | socio medic assess context rehabilit legal requir surround medic rehabilit firm anchor german social legisl see sozialgesetzbuch ix rehabilit und teilhab von menschen mit behinderung social law book ix rehabilit particip disabl peopl disabl peopl peopl threaten disabl thus legal elig rehab medic rehab staff must deal mani socio medic question whole rehabilit process process requir detail sound knowledg relev legal requir definit terminolog | D006233 | T101 |
34,661,693 | variat sever adjust resourc use outcom intens care unit intens care patient increas risk death care expens investig whether risk adjust mortal resourc use achiev survivor chang time variat associ variabl relat intens care unit icu organ structur | D003422;D007362 | T058;T093;T073 |
34,661,692 | nt opt thing think get sore knee nt expos stupid risk either patient experi second acl injuri interview studi purpos qualit studi describ women experi anterior cruciat ligament reconstruct aclr subsequ acl ruptur identifi potenti facilit barrier cope rehabilit second injuri | D000070598;D059549;D000083102 | T061;T037 |
34,661,691 | prehospit fast reduc time admiss oper treatment prospect random multicent trial focus assess sonographi trauma fast exam establish trauma care diagnost procedur ultrasound perform prehospit care improv earli treatment manag patient prospect random clinic trial want assess whether pre hospit fast p fast influenc pre hospit strategi time oper treatment | D000007;D004632 | T058;T061;T093;T037 |
34,661,690 | non consensu forward person erot photo school survey school princip schleswig holstein sexual border violat use digit media internet digit media entail risk opportun children young peopl one risk pose case person erot photo schoolchildren forward children adolesc concern psychosoci consequ serious | D020407;D060145 | T052;T170;T066;T073 |
34,661,689 | lifetim preval nonconsensu sexual intercours touch associ health relat factor result german health sexual survey gesid last decad negat effect sexual violenc health becom focus health polici worldwid far repres popul data lifetim preval differ age group specif link health relat factor germani lack | D011788;D014110 | T042;T078 |
34,661,686 | multipl myeloma pathologist perspect multipl myeloma mm one common hematolog neoplasm account approxim human cancer | D008998;D009101;D010954 | T191 |
34,661,685 | structur report radiolog german european radiolog societi point view numer public shown valu structur report communic refer physician usag clinic report data context despit topic present known radiolog mani year widespread adopt structur report clinic routin still lack major radiolog societi publish posit statement favor structur report pursu various relat initi among develop mainten open avail structur report templat repositori well qualiti control report templat develop standard terminolog articl highlight effort german radiolog societi european societi radiolog topic structur report provid overview pros con well public avail resourc | D011871;D011873 | T091;T170 |
34,661,684 | spinal neoplasm spinal neoplasm general rare disord play import role differenti diagnosi space occupi mass spinal axi although sever differ classif criteria histolog origin digniti posit relationship spine standard classif spinal neoplasm base relationship dura mater extraspin intraspin extramedullari intraspin intramedullari use magnet reson imag gold standard morpholog imag spinal neoplasm follow comput tomographi addit local symptom patient age essenti respect diagnosi possibl tumor entiti | D013125 | T191 |
34,661,682 | erector spina plane block reduc pain laparoscop cholecystectomi laparoscop cholecystectomi patient moder pain earli postop period accord sever studi erector spina plane esp block valuabl part multimod analgesia intent evalu esp block influenc postop pain score opioid consumpt laparoscop cholecystectomi | D000698;D017081;D009407 | T061 |
34,661,679 | gisenosid rg attenu cadmium induc neurotox vitro vivo attenu oxid stress inflamm gisenosid rg potent neuroprotect ginseng aim studi investig elimin effect rg cadmium cd induc neurotox | D002104 | T131;T196 |
34,661,678 | modifi nuss procedur novel steel bar patient pectus excavatum post congenit heart surgeri pectus excavatum pe secondari patient underw sternotomi cardiac surgeri retrostern adhes increas complex risk tradit nuss repair thus summar outcom modifi nuss procedur use newli design bar | D005660;D006330 | T019 |
34,661,677 | acut kidney injuri patient hospit covid isar ccp uk studi prospect multicentr cohort studi acut kidney injuri aki common coronavirus diseas covid studi investig adult hospit covid hypothes risk factor aki would includ comorbid non white race | D058186;D000086382 | T047;T037;T067 |
34,661,674 | improv dna barcod librari mosquito speci new identif discoveri north central argentina famili culicida repres speci argentina mani epidemiolog import dna barcod effect tool identifi mosquito speci know genet variabl establish phylogenet relationship work aim explor mosquito divers employ differ speci delimit approach establish formal dna barcod librari argentinian mosquito fauna barcod fragment specimen argentinian mosquito speci genera aedeomyia theobald diptera culicida anophel meigen diptera culicida coquillettidia dyar diptera culicida culex l diptera culicida haemagogus williston diptera culicida mansonia blanchard diptera culicida nyssorhynchus blanchard diptera culicida ochlerotatus lynch arriblzaga diptera culicida psorophora robinneau desvoidi diptera culicida uranotaenia lynch arriblzaga diptera culicida sequenc anoth sequenc obtain public databas establish phylogenet relationship use maximum likelihood bayesian infer speci boundari base three approach abgd gmyc mptp sixteen speci sequenc recov monophylet also recogn molecular oper taxonom unit accord three methodolog dispar morpholog barcod base identif could explain synonymi speci complex occurr hybrid incomplet lineag sort effect geograph scale sampl twenti sequenc speci new barcod argentina first scienc increas six number speci genera respect barcod sequenc argentina new speci record provid | D063147;D058893 | T062;T087;T054 |
34,661,672 | global implement tobacco demand reduct measur specifi framework convent tobacco control world first global health treati framework convent tobacco control fctc aim reduc tobacco product demand focus tobacco tax smoke ban health warn label tobacco advertis ban previous studi almost unanim suggest fctc prompt countri implement effect tobacco demand reduct polici | D019460;D062789 | T092;T131;T073;T109 |
34,661,671 | bias varianc compon estim swine crossbreed scheme use select genotyp phenotyp strategi select genotyp crossbr cb anim includ tradit purebr pb domin genet evalu shown provid increas respons select cb perform howev inclus phenotyp select genotyp cb anim without phenotyp non genotyp cohort could caus bias estim varianc compon vc subsequ estim breed valu ebv object studi determin impact select cb genotyp vc estim subsequ bias ebv non genotyp cb anim includ genet evalu swine crossbreed scheme produc way cb anim simul creat select genotyp dataset breed scheme consist three pb breed male femal f cross femal cb progeni eighteen chromosom qtl k snp marker simul pb cb perform consid moder herit h factor evalu follow cb phenotyp genotyp inclus n n genet correl pb cb perform rpc select genotyp strategi genotyp strategi includ follow random random cb select top highest cb phenotyp extrem half highest half lowest cb phenotyp top extrem select genotyp strategi consid select anim full sib fs famili among cb popul generat pb select candid contribut phenotyp genotyp record scenario replic time vc estim pb cb perform util bivari model use pedigre relationship dam cb anim consid unknown estim valu vc pb perform statist differ true valu top select genotyp strategi produc deflat estim phenotyp vc cb perform compar true valu use estim vc topt extremet produc bias ebv yet ebv pb select candid cb perform accur use extremet result suggest random select cb anim genotyp select genotyp top extrem cb anim within full sib famili lead accur estim addit genet vc cb perform unbias ebv | D001947;D008957 | T040;T170 |
34,661,665 | extern valid predict model acut kidney injuri follow noncardiac surgeri simpl postop aki risk spark index predict model postop acut kidney injuri po aki patient undergo noncardiac surgeri extern valid perform | D011237 | T081 |
34,661,659 | challeng opportun regul miner transport rice iron fe essenti miner plant defici well toxic sever affect plant growth develop although fe ubiquit miner soil acquisit plant difficult regul particular acid alkalin soil alkalin condit lime abund fe miner element spare solubl contrast low ph condit especi paddi field fe toxic could occur fe uptak complic could integr copper cu manganes mn zinc zn cadmium cd uptak plant develop sophist mechan regul fe uptak soil transport root ground part review recent develop understand metal transport discuss strategi effect regul metal transport plant particular focus rice | D002104 | T131;T196 |
34,661,658 | updat deep learn research ophthalmolog ophthalmolog one earli adopt artifici intellig ai within medic field deep learn dl particular garner signific attent due avail larg amount data digit ocular imag current ai ophthalmolog main focus improv diseas classif support decis make treat ophthalm diseas diabet retinopathi age relat macular degener amd glaucoma retinopathi prematur rop howev dl system dlss develop thus far remain research stage hand abl achiev clinic translat phenomenon due combin factor includ concern secur privaci poor generaliz trust explain issu unfavor end user percept uncertain econom valu overcom challeng would requir combin approach first emerg techniqu feder learn fl generat adversari network gan autonom ai blockchain play increas critic role enhanc privaci collabor dls perform next complianc report regulatori guidelin consort ai stard ai requir order improv transpar minim abus ensur reproduc third framework requir obtain patient consent perform ethic assess evalu end user percept last proper health econom assess hea must perform provid financi visibl earli phase dls develop necessari manag resourc prudent guid develop dls | D035843;D000077321;D005128;D009885 | T091;T062;T047;T066 |
34,661,657 | transposon insert mutat antarct psychrotroph fungus red pigment product adapt normal temperatur polar region rich microbi product resourc geomyc sp wnf antarct psi chrotroph filament fungus produc high qualiti red pigment potenti industri use howev effici biosynthesi red pigment realiz low temperatur bring difficult control high cost larg scale ferment studi aim develop transposon insert mutat method improv cell growth red pigment product adapt normal temperatur genet manipul system fungus first develop antibiot marker screen protoplast prepar transform optim transform effici final achiev transpos insert system establish use helitron fot impala transposon transposit effici reach respect mutant mp achiev highest red pigment product od c higher wild type strain mutant mp reach maximum red pigment product od c twofold wild type strain mutant mp mp broke repress mechan red pigment biosynthesi wild type allow product c cell growth eight mutant grew remark better biomass higher wild type c studi establish effici genet manipul transposon insert mutat platform polar filament fungus provid refer genet breed psychrotroph fungi polar region | D001203;D013696 | T004;T081 |
34,661,656 | direct spectrophotometr method reliabl initi assess total bilirubin neonat venous plasma determin consist bilirubin valu direct spectrophotometr ds colorimetr diazo diazo method neonat venous plasma specimen | D001663;D012107 | T121;T109;T123;T170;T169;T062;T081;T096 |
34,661,655 | character streptomyc sp ls high product echinomycin potent antituberculosi synergist antifung antibiot biolog activ microbi strain design ls isol soil sampl collect yaoli virgin forest jiangxi provinc china strain abl produc high yield echinomycin mgl even nonoptim cultur condit propos serv promis sourc echinomycin studi echinomycin exhibit strong anti mycobacterium tuberculosi hrv activ synergist antifung effect great reduc dosag posaconazol candida albican sc strain belong genus streptomyc accord morpholog rdna phylogenet analysi rdna found highest sequenc ident streptomyc fuscichromogen similar extens nuclear magnet reson mass spectroscop data use determin structur echinomycin strain fuscichromogen previous report produc echinomycin strain ls may exploit new potenti sourc commerci product echinomycin also work first report new synergist antifung activ echinomycin studi synergist mechan help guid develop antifung agent | D000935;D004448;D013302 | T195;T007;T121;T116 |
34,661,654 | impact train session prescrib relat prescript cefotaxim ceftriaxon elder patient prescript ceftriaxon limit patient biliari tract infect lack intraven access specif train session prescrib clinic relev econom valu prescrib cefotaxim instead ceftriaxon might decreas use latter geriatr medicin | D002439;D002443 | T195;T109 |
34,661,653 | multipl categori non cardiac qt prolong drug associ increas risk hospit cardiac arrest real world data popul base studi drug caus qt prolong target effect non cardiac qt prolong drug qt drug increas risk hospit cardiac arrest ohca drug categor multipl clinic wide use crediblemedsorg list categori known risk torsad de point categori possibl risk torsad de point particular clinic relev howev categori stratifi analysi ohca risk present unavail | D002317;D008133;D058687;D016171 | T033;T047;T121;T046 |
34,661,652 | aortic root diamet hypertens patient various stage obstruct sleep apnea obstruct sleep apnea osa risk factor sever cardiovascular diseas investig associ aortic root diamet hypoxia relat paramet hypertens patient osa | D006973;D020181 | T047 |
34,661,651 | loss function mutat cardiac ryanodin receptor channel caus various type arrhythmia includ long qt syndrom gain function mutat ryr encod cardiac ryanodin receptor channel ryr caus catecholaminerg polymorph ventricular tachycardia cpvt wherea genotyp phenotyp correl loss function mutat remain unknown due small number analys mutat studi aim investig genotyp phenotyp correl patient loss function ryr mutat | D008133;D017180 | T033;T047;T046 |
34,661,650 | nucleotid bind leucin rich repeat protein miss link control cell fate plant adapt hostil environ program cell death tight regul genet control process lead cell suicid elimin cell either longer need damagedharm nucleotid bind leucin rich repeat protein recent emerg novel class ca permeabl channel oper plant immun respons viewpoint argu uniqu structur channel permeabl cation specif oper make ideal candid mediat cell signal adapt respons pathogen also broad rang abiot stress factor | D000090263;D010944 | T116;T002;T123 |
34,661,649 | mobil health technolog remot home monitor surgeri meta analysi mobil health mhealth technolog propos method improv post discharg surveil littl known mhealth use track patient surgeri whether use associ differ postop recoveri | D011788 | T078 |
34,661,648 | differ transcript level corazonin elevenin pdf accord bodi color two spot cricket gryllus bimaculatus bodi color insect chang accord live environ physiolog stress possibl involv endocrin factor date predomin bioactiv peptid corazonin elevenin pigment dispers factor pdf illumin involv bodi color insect crustacean examin possibl factor would contribut bodi color chang via melan two spot cricket gryllus bimaculatus whose bodi color chang accord popul densiti drastic quantit analys reveal higher transcript level corazonin elevenin crowd condit cricket wherea transcript level pdf higher isol condit cricket howev bodi color chang knockdown corazonin elevenin pdf rna interfer present data indic color mechan g bimaculatus differ control previous observ locusta migratoria close relat orthopteran speci | D006135 | T204 |
34,661,647 | clinic signific cux mutat frequent subclon common myeloid disord high number co mutat gene dysplast featur cux mutat report myeloid neoplasm aim character mutat landscap clonal architectur clinic characterist myeloid disord cux variant | D009190;D009196 | T191;T046 |
34,661,646 | assess line immunoassay detect mi antibodi result singl academ center investig evalu perform characterist line immunoassay lia detect mi antibodi associ dermatomyos dm | D000974;D001323 | T129;T116 |
34,661,642 | expand spectrum adult ntrk rearrang spindl cell neoplasm recurr ntrk sqstm fusion spindl cell tumor decept bland morpholog ntrk rearrang spindl cell neoplasm infantil fibrosarcoma emerg entiti tumor demonstr wide variat clinic histopatholog featur report case ntrk rearrang spindl cell neoplasm bear decept bland morpholog | D018204;D020917 | T192;T191;T116;T126 |
34,661,634 | cost effect recommend surgeon general call action control hypertens respons high preval hypertens suboptim rate blood pressur bp control unit state surgeon general releas call action control hypertens call action fall address negat consequ uncontrol bp addit morbid mortal associ hypertens hypertens annual cost us healthcar system billion call action make recommend improv bp control purpos review summar literatur cost effect strategi identifi number studi demonstr cost save cost effect recommend call action includ strategi promot access avail physic activ opportun healthi food option within communiti advanc use standard treatment approach guidelin recommend care promot use healthcar team manag hypertens empow equip patient use self measur bp monitor medic adher strategi current review identifi numer cost effect method achiev surgeon general recommend improv bp control futur work determin cost effect american colleg cardiolog american heart associ hypertens guidelin intervent lower therapeut inertia optim team base care strategi among area research econom evalu studi also priorit generat comprehens data provid effici high valu care improv bp control | D006973 | T047 |
34,661,633 | multisystem inflammatori syndrom children critic care set multisystem inflammatori syndrom children new syndrom hypothes connect covid pandem children present like sar cov infect exposur vagu symptom includ fever gastrointestin distress andor rash | D000086382;D058873 | T047;T067 |
34,661,632 | dynam prokaryot eukaryot microbi communiti cyanobacteri bloom toxic cyanobacteri bloom frequent develop eutroph freshwat bodi worldwid microcysti speci produc microcystin mcs cyanotoxin certain bacteria harbor mlr gene cluster especi mlra capabl degrad mcs howev mc degrad bacteria may possess lack mlr gene mlr mlr genotyp respect studi investig genotyp predomin contribut biodegrad cyanobacteri predat communiti structur chang total mc concentr aquat environ genotyp coexist mlr predomin indic negat correl mlra gene copi abund total mc concentr highest mc concentr predat pressur phyllopoda copepoda monogononta rotif reduc thus mcs may toxic cyanobacteri predat result suggest cooper mc degrad bacteria predat may reduc microcysti abund mc concentr | D056890 | T204 |
34,661,630 | pksps novel method predict kinas specif phosphoryl site base maximum weight bipartit match algorithm phosphoryl sequenc enrich analysi develop biotechnolog larg number phosphoryl site experiment confirm collect kinas annot sinc experiment method detect kinas specif phosphoryl site expens accident comput method propos predict kinas site method consid singl sequenc inform singl function network inform studi new method predict kinas specif phosphoryl site pksps develop predict kinas specif phosphoryl site human protein combin pksps net pksps seq consid protein protein interact ppi network inform sequenc inform pksps net kinas kinas substrat substrat similar quantifi base topolog similar protein ppi network maximum weight bipartit match algorithm propos predict kinas substrat relationship pksps seq phosphoryl sequenc enrich analysi use analyz similar local sequenc around phosphoryl site predict kinas specif phosphoryl site ksp pksps prove effect pksps net pksps seq differ set kinas comparison result show pksps method perform better exist method final case studi demonstr effect pksps predict kinas specif phosphoryl site open sourc code data pksps obtain https githubcomguoxinyunncupksp | D000465;D011494 | T116;T170;T126 |
34,661,627 | moai multi outcom interact identif approach reveal interact vaspin carcinoembryon antigen colorect cancer prognosi identifi character interact risk factor multipl outcom multi outcom interact one greatest challeng face complex multifactori diseas howev exist approach sever limit identifi multi outcom interact address issu propos multi outcom interact identif approach call moai moai motiv limit estim interact simultan occur multi outcom success pareto set filter oper identifi multi outcom interact moai permit identif interact multipl outcom applic popul base studi design experiment result exhibit exist approach effect use identifi multi outcom interact wherea moai obvious exhibit superior perform identifi multi outcom interact appli moai identifi interact risk factor colorect cancer crc metastas mortal prognost outcom interact vaspin carcinoembryon antigen cea found interact indic patient crc character higher vaspin cea level could simultan increas metastas mortal risk immunostain evid reveal determin multi outcom interact could effect identifi differ non metastasessurviv metastasesdeceas patient offer multi prognost outcom risk estim crc knowledg first report multi outcom interact associ complex multifactori diseas moai freeli avail https sitesgooglecomviewmoaitoolhom | D002272;D015179 | T129;T191;T116 |
34,661,625 | variabl retin oxygen metric healthi diabet subject previous studi report alter total retin blood flow trbf oxygen deliveri oxygen metabol mo oxygen extract fraction oef due retin diseas purpos current studi determin variabl establish normal confid interv cis metric | D003920;D010100 | T047;T121;T196;T123 |
34,661,624 | novel smartphon base teleophthalmolog enabl widefield fundus imag devic autocaptur algorithm widefield imag detect sign retin patholog extend beyond posterior pole current move forefront posterior segment imag report novel smartphon base telemedicin enabl mydriat widefield retin imag devic autofocus autocaptur capabl use non specialist oper | D009885;D017216 | T091;T058 |
34,661,623 | perceptu learn object recognit simul retin implant percept effect video train retin implant ris provid new vision patient suffer photoreceptor degener retina limit vision gain ri howev leav room improv train regim | D012162;D057488 | T074;T046 |
34,661,622 | metal oxid engin nanomateri modul rabbit corneal fibroblast myofibroblast transform corneal keratocyt fibroblast myofibroblast kfm transform play critic role corneal stromal wound heal howev impact engin nanomateri enm found increas number commerci product process poor studi studi investig effect metal oxid enm kfm transform vitro vivo | D058628;D049329 | T025;T073 |
34,661,621 | ocular microbiom alter sampl modal age studi ocular microbiom use varieti sampl techniqu studi direct compar differ sampl method appli eye one anoth refer standard corneal epitheli biopsi address lack compar microbiom three conjunctiv swab corneal epitheli biopsi | D001419;D064307 | T001;T032;T007;T028 |
34,661,620 | key find french bionutrinet project organ food base diet descript determin relationship health environ studi investig relationship organ food consumpt dietari pattern monetari diet cost health environ address issu consortium french epidemiologist nutritionist economist toxicologist launch bionutrinet project ffq document usual organ nonorgan convent food consumpt approxim nutrinet sant particip individu organ convent food intak merg price environment pesticid residu data set distinguish convent organ farm method mani studi conduct character organ consum environment impact ie greenhous gas emiss energi demand land use organ food consumpt impact health observ organ consum diet healthier richer plant base food nonorgan consum diet associ higher monetari cost lower environment impact reduc exposur certain pesticid residu regular consumpt organ food associ reduc risk obes type diabet postmenopaus breast cancer lymphoma although sever observ confirm sever studi conduct countri result replic cultur set coupl experiment studi abl draw causal conclus final main find bionutrinet project organ food consumpt could associ posit extern human health environ organ base diet accompani dietari shift toward plant base diet allow better planetari human health | D003924;D058870 | T047;T168 |
34,661,617 | make progress way go age age care home collect care home enabl peopl advanc physic cognit impair live well h support staff featur care system countri prove pivot coronavirus diseas covid respons search age age care home articl publish sinc collat age age care home collect collect draw togeth import paper show age age help shape grow care home research collect outlin technic issu research face group togeth import feasibl trial conduct sector look challeng measur qualiti life work routin data care home bring togeth observ studi consid loneli function depend stroke outcom prescrib acut deterior health servic research care home repres two studi demonstr realist evalu way make sens servic innov paper includ consid non pharmacolog strategi resid dementia end life care sexual intimaci care home workforc given import covid pandem care home care home covid paper publish age age date includ final group paper present innov approach research care home give voic resid andor staff collat present way move toward resid care home centr research agenda | D000086382;D011788 | T047;T078;T067 |
34,661,613 | behavior intervent social challeng children adolesc systemat review meta analysi social deficit common disabl featur mani pediatr disord howev whether behavior intervent associ benefit children adolesc social deficit poor understood | D001521;D012919;D000083282 | T054;T061 |
34,661,612 | associ sweeten beverag tax soda consumpt high school student sweeten beverag tax one polici approach reduc intak ad sugar soda lead sourc ad sugar us diet studi examin tax influenc sweeten beverag intak youth | D004326;D013334 | T040;T098;T081 |
34,661,608 | locat specif thick pattern intermedi age relat macular degener reveal anatom differ multipl retin layer examin individu retin layer locat specif pattern thick intermedi age relat macular degener iamd use optic coher tomographi oct | D057216;D014792 | T201;T081 |
34,661,606 | anaplast thyroid carcinoma cytomorpholog featur fine needl aspir associ diagnost challeng anaplast thyroid carcinoma atc aggress malign earli diagnosi often aid fine needl aspir fna key improv patient prognosi current literatur describ cytolog featur cfs entiti comprehens examin cfs yet perform | D065646;D013964 | T191 |
34,661,602 | program cortic er collaps drive select er degrad inherit yeast meiosi endoplasm reticulum er carri essenti conserv cellular function depend mainten structur subcellular distribut report development regul chang er morpholog composit bud yeast meiosi conserv differenti program give rise gamet subset cortic er collaps away plasma membran anaphas ii thus separ spatial distinct compart program collaps depend transcript factor ndt conserv er membran structur protein lnp reticulon actin cytoskeleton subset er retain mother cell plasma membran exclud gamet cell via action er plasma membran tether protein er remodel coupl er degrad select autophagi reli er collaps regul time express autophagi receptor atg thus development program chang er morpholog determin select degrad inherit er subdomain gamet | D008540 | T043 |
34,661,601 | stay power hematopoiet stem cell hematopoiet stem progenitor cell hspcs use special adhes structur refer magnupodium stay hematopoiet nich bessey et al j cell biolhttp doiorgjcb defin new characterist magnupodium includ centriol polar necessari suffici role cxcr signal | D006412;D015398 | T044;T025;T043 |
34,661,592 | regul stem cell fate use nanostructur mediat physic signal one major issu tissu engin regul stem cell differenti toward specif lineag unlik biolog chemic signal physic signal adjust properti appli stem cell time local manner thus make hot topic research field biomateri tissu engin cell biolog accord signal sens cell physic signal use regul stem cell fate classifi six categori mechan light thermal electr acoust magnet case extern macroscop physic field use modul stem cell fate local physic signal accept surfac receptor regul stem cell differenti via nanoscal fibrin polysaccharid fiber howev surfac receptor relat certain kind physic signal still unknown recent signific progress made develop function materi energi convers consequ local physic field produc absorb energi extern physic field subsequ releas anoth type local energi function nanostructur base concept propos methodolog util stem cell engin regul stem cell fate via nanostructur mediat physic signal review combin effect various approach mechan physic signal provid perspect stem cell fate promot nanostructur mediat physic signal expect review aid develop remot control wireless platform physic guid stem cell differenti vitro vivo use optim stimul paramet mechanist investig drive progress research field materi scienc cell biolog clinic research | D049329;D013234 | T025;T073;T081 |
34,661,590 | multiparametr nanoparticl induc toxic readout singl cell resolut hepg multicellular tumour spheroid use nanomateri therapeut deliveri vehicl requir care pre clinic evalu particular import regard measur cellular toxic ideal assess multipl paramet parallel various relev subcellular organell recent year becom evid vitro monolay grown cell alway accur predict toxic respons seen vivo need sophist vitro cell model employ greater depth characteris work present autom high content screen microscopi approach quantifi nanoparticl induc toxic three dimension multicellular tumour spheroid mcts cell model proof principl perform compar toxic profil studi carboxyl versus amin modifi polystyren nanoparticl hepg spheroid follow treatment nanoparticl type demonstr sever hundr spheroid various size morpholog profil singl well use autom high content imag analysi provid first level inform spheroid health respons nanoparticl treatment use rang fluoresc report assess membran permeabl lysosom function mitochondri activ also show nanoparticl induc toxic inform obtain individu cell subcellular resolut strike work demonstr individu cell behav consist manner within spheroid structur exposur nanoparticl highlight need toxic studi assess appropri number spheroid also import extract inform subcellular level | D053758;D009369 | T191;T073 |
34,661,584 | pancreat duct infus effect select method drug viral deliveri pancrea bifunct organ endocrin exocrin compon number patholog afflict pancrea includ diabet pancreat pancreat cancer three diseas mark activ area studi develop immedi therapi also better understand pathophysiolog tool area studi pancreat duct infus import techniqu allow lineag trace gene introduct cell line specif target techniqu requir intric dissect second portion duodenum ampulla follow occlus bile duct cannul pancreat duct although techniqu technic challeng first applic myriad ambigu specif procedur group highlight need standard protocol work describ express green fluoresc protein gfp within pancrea pancreat duct infus viral vector express gfp versus sham surgeri infus therefor express specif pancrea without express present tissu type | D010190;D004364 | T191;T121 |
34,661,583 | label extracellular vesicl monitor migrat uptak cartilag explant extracellular vesicl ev use differ studi prove potenti cell free treatment due cargo deriv cellular sourc platelet lysat pl use treatment ev expect enter target cell effect respons research pl deriv ev studi cell free treatment osteoarthr oa thus method set label ev test uptak cartilag explant pl deriv ev label lipophil dye pkh wash twice column test vitro inflamm driven oa model h particl quantif nanoparticl track analysi nta hour cartilag explant fix paraffin cut section mount slide observ confoc microscop allow verif whether ev enter target cell chondrocyt period analyz direct effect | D000067128;D053758;D010003 | T026;T047;T073 |
34,661,582 | simultan brightfield fluoresc optic coher tomograph imag contract cardiac trabecula ex vivo cardiac muscl intracellular ca transient activ contractil myofila caus contract macroscop shorten geometr deform understand intern relationship event limit neither see insid muscl precis track spatio tempor natur excit contract dynam resolv problem construct devic combin suit imag modal specif integr brightfield microscop measur local chang sarcomer length tissu strain fluoresc microscop visual ca transient optic coher tomograph captur tissu geometr chang throughout time cours cardiac cycl present imag infrastructur associ data collect framework data collect isol rod like tissu structur known trabecula carnea instrument pair posit control platinum hook hold end ex vivo muscl sampl continu superfus nutrient rich salin solut hook independ control permit real time control muscl length forc lengthwis translat enabl piecewis scan sampl overcom limit associ relat size microscop imag window length typic trabecula platinum electrod either end muscl chamber stimul trabecula user defin rate exploit stimul signal trigger synchron data imag window reconstruct entir sampl twitch steadi state condit appli imag process techniqu brightfield imag data provid tissu displac sarcomer length map collect data incorpor experi model pipelin provid deeper understand muscl contractil homogen heterogen physiolog pathophysiolog | D002118;D009200 | T121;T123;T042;T196;T040 |
34,661,581 | detect plasmodium sporozoit anophel mosquito use enzym link immunosorb assay plasmodium sporozoit infect stage malaria parasit infect human sporozoit resid salivari gland femal anophel mosquito transmit human via mosquito bite blood feed presenc sporozoit mosquito salivari gland thus defin mosquito infecti determin whether anophel mosquito carri plasmodium sporozoit enzym link immunosorb assay elisa method standard tool detect plasmodium circumsporozoit protein csp major surfac protein sporozoit method head along thorax mosquito separ abdomen homogen subject sandwich elisa detect presenc csp specif plasmodium falciparum two subtyp vk vk plasmodium vivaxthi method use studi malaria transmiss includ season dynam mosquito infect speci major malaria vector studi site | D000852;D010961 | T204 |
34,661,580 | separ rat epidermi dermi thermolysin detect site specif inflammatori mrna protein easi use inexpens techniqu need determin site specif product inflammatori mediat neurotrophin skin injuri inflamm andor sensit goal studi describ epiderm dermal separ protocol use thermolysin proteinas activ c illustr procedur spragu dawley rat anesthet right hind paw inject carrageenan six twelv hour inject rat inflamm nave rat euthan piec hind paw glabrous skin place cold dulbecco modifi eagl medium epidermi separ basement membran dermi thermolysin pbs calcium chlorid next dermi secur microdissect forcep epidermi gentl teas away toluidin blue stain tissu section show epidermi separ clean dermi basement membran keratinocyt cell layer remain intact epiderm rete ridg along indent dermal papilla clear observ qualit real time rt pcr use determin nerv growth factor interleukin express level western blot immunohistochemistri final perform detect amount nerv growth factor report illustr cold thermolysin digest effect method separ epidermi dermi evalu mrna protein alter inflamm | D020405;D004817 | T024 |
34,661,579 | dissect immunostain larval salivari gland anophel gambia mosquito mosquito salivari gland sgs requisit gateway organ transmiss insect born pathogen diseas caus agent includ virus plasmodium parasit caus malaria accumul secretori caviti sg cell pois transmiss vertebr host subsequ blood meal adult gland form elabor larval sg duct bud remnant persist beyond earli pupal sg histolysi larval sg ideal target intervent limit diseas transmiss understand larval sg develop help develop better understand morpholog function adapt aid assess new intervent target organ video protocol demonstr effici techniqu isol fix stain larval sgs anophel gambia mosquito gland dissect larva ethanol solut fix methanol glacial acet acid mixtur follow cold aceton wash rins phosphat buffer salin pbs sgs stain broad array marker dye andor antisera sg express protein method larval sg isol could also use collect tissu situ hybrid analysi transcriptom applic proteom studi | D000852 | T204 |
34,661,578 | tail vein transect bleed model fulli anesthet hemophilia mice tail bleed model import tool hemophilia research specif assess procoagul effect tail vein transect tvt surviv model prefer mani set due sensit clinic relev dose fviii wherea establish model tail clip model requir higher level procoagul compound avoid use surviv endpoint develop tvt model establish blood loss bleed time endpoint full anesthesia entir experi briefli anesthet mice posit tail submerg temper salin c dose test compound right later tail vein min left later tail vein transect use templat guid tail return salin bleed episod monitor record min collect blood bleed occur min min min post injuri clot challeng gentl wipe cut twice wet gauz swab min blood loss quantifi amount hemoglobin bled salin fast relat simpl procedur result consist reproduc bleed compar tvt surviv model use human procedur without compromis sensit pharmacolog intervent furthermor possibl use gender reduc total number anim need bred adher principl r potenti limit bleed model stochast natur hemostasi reduc reproduc model counter manual clot disrupt ensur clot challeng monitor prevent primari platelet hemostasi stop bleed addit catalog bleed injuri model provid option character procoagul effect standard human manner | D006467 | T047 |
34,661,577 | rate l dopa induc dyskinesia unilater ohda lesion rat model parkinson diseas l dopa induc dyskinesia lid refer motor complic aris prolong l dopa administr patient parkinson diseas pd common pattern observ clinic peak dose dyskinesia consist clinic manifest choreiform dyston ballist movement hydroxydopamin ohda rat model pd mimic sever characterist lid repeat l dopa administr ohda lesion rat exhibit dyskinet like movement eg abnorm involuntari movement aim protocol demonstr induc analyz aim ohda lesion rat dopaminerg deplet nigrostriat pathway repeat administr week l dopa mgkg combin mgkg benserazid induc develop aim time cours analysi reveal signific increas aim min peak dose dyskinesia rodent model lid import preclin tool identifi effect antidyskinet intervent | D004409;D010300 | T047 |
34,661,576 | deep vascular imag eye flow enhanc ultrasound retina within eye one energi demand tissu bodi thus requir high rate oxygen deliveri rich blood suppli capillari lamina choroid line outer surfac retina domin sourc oxygen vertebr retina howev vascular bed challeng imag tradit optic techniqu due posit behind high light absorb retina describ high frequenc ultrasound techniqu subsequ flow enhanc imag deep vascular bed cm eye high spatiotempor resolut non invas method work well speci nucleat red blood cell non mammalian fetal anim model allow generat non invas three dimension angiographi without use contrast agent independ blood flow angl higher sensit doppler base ultrasound imag techniqu | D012160;D012171 | T023 |
34,661,575 | isol endotheli cell lumen mous carotid arteri singl cell multi omic experi atherosclerosi inflammatori diseas arteri region expos disturb blood flow flow flow regul express gene endothelium transcriptom epigenom level result proatherogen respons recent singl cell rna sequenc scrnaseq singl cell assay transposas access chromatin sequenc scatacseq studi perform determin transcriptom chromatin access chang singl cell resolut use mous partial carotid ligat pcl model endotheli cell ec repres minor fraction total cell popul arteri wall lumin digest method use obtain ec enrich singl cell prepar studi mice subject pcl surgeri induc flow left carotid arteri lca use right carotid arteri rca control carotid arteri dissect two day two week post pcl surgeri lumen carotid subject collagenas digest endotheli enrich singl cell singl nuclei obtain singl cell singl nuclei prepar subsequ barcod use x genom microfluid setup barcod singl cell singl nuclei util rna prepar librari generat sequenc high throughput dna sequenc post bioinformat process scrnaseq scatacseq dataset identifi various cell type lumin digest primarili consist ec smooth muscl cell fibroblast immun cell also present ec enrich method aid understand effect blood flow endothelium could difficult total arteri digest method ec enrich singl cell prepar method use perform singl cell omic studi ec knockout transgen mice effect blood flow gene studi import techniqu adapt isol ec enrich singl cell human arteri explant perform similar mechanist studi | D050197;D042783 | T025;T047;T046 |
34,661,574 | serial block face scan electron microscopi sbem studi dendrit spine three dimension electron microscopi em give possibl analyz morpholog paramet dendrit spine nanoscal resolut addit featur dendrit spine volum spine post synapt densiti psd repres post synapt part synaps presenc presynapt termin smooth endoplasm reticulum atyp form psd eg multi innerv spine observ em employ serial block face scan electron microscopi sbem possibl obtain em data easier reproduc manner perform tradit serial section show prepar mous hippocamp sampl sbem analysi protocol combin immunofluoresc studi dendrit spine mild fixat perfus allow us perform immunofluoresc studi light microscopi one half brain half prepar sbem approach reduc number anim use studi | D049229;D013569 | T026;T030 |
34,661,573 | high throughput robust high time flexibl method surfac steril arabidopsi seed arabidopsi far plant model speci wide use function studi surfac steril arabidopsi seed fundament step requir toward end thus paramount establish high throughput arabidopsi seed surfac steril method handl ten hundr sampl eg transgen line ecotyp mutant seed surfac steril method base effici elimin liquid tube homemad suction devic construct common vacuum pump present studi dramat reduc labor intens hand time method handl sever hundr sampl one day possibl littl effort seri time cours analys indic high flexibl time rang surfac steril maintain high germin rate method could easili adapt surfac steril kind small seed simpl custom suction devic accord seed size speed desir elimin liquid | D017360;D012639;D013242 | T058;T002 |
34,661,572 | measur glutam uptak use radiolabel l h glutam acut transvers slice obtain rodent resect hippocampus glutam remov extracellular space high affin na depend transport essenti ensur brain intrins connect mechan work proper homeostasi maintain hippocampus uniqu brain structur manag higher cognit function subject sever studi regard neurolog diseas investig physiolog patholog mechan rodent model benefit acut hippocamp slice ah prepar ah advantag provid reliabl inform cell function sinc cytoarchitectur synapt circuit preserv although ah prepar common use neurochemistri laboratori possibl find methodolog differ literatur consid distinct slice prepar protocol might chang hippocamp region analyz current protocol propos standard techniqu obtain transvers ah resect hippocampus simpl perform protocol may use mice rat experiment model allow sever ex vivo approach investig neurochem dynam dorsal intermedi ventral hippocampus differ background eg transgen manipul vivo manipul eg pharmacolog treatment suitabl rodent model studi clinic disord dissect hippocampus rodent brain transvers slice along septo tempor axi thick obtain ah contain distinct part hippocampus subject individu neurochem investig exampl neurotransmitt transport use respect substrat hippocampus present high densiti excitatori synaps glutam import neurotransmitt brain glutamaterg system interest target vivo observ phenomena thus current protocol provid detail step explor glutam uptak ex vivo ah use l h glutam use protocol investig hippocamp function may help better understand influenc glutam metabol mechan neuroprotect neurotox | D018698;D012377 | T116;T121;T015;T123 |
34,661,571 | three dimension spheroid model investig tumor stromal interact hepatocellular carcinoma aggress lack well toler wide effect treatment advanc hepatocellular carcinoma hcc predomin form liver cancer ration rank second common caus cancer relat death preclin model need adapt recapitul human condit select best therapeut candid clinic develop aid deliveri person medicin three dimension cellular spheroid model show promis emerg vitro altern two dimension monolay cultur describ tumor spheroid model exploit abil individu cell aggreg maintain hang droplet repres vivo environ standard monolay furthermor spheroid produc combin homotyp heterotyp cell reflect cellular heterogen vivo potenti enabl studi environment interact influenc progress treatment respons current research optim cell densiti form homotyp heterotyp tumor spheroid immobil cell suspens lid standard cm petri dish longitudin analysi perform generat growth curv homotyp versus heterotyp tumorfibroblast spheroid final prolif impact fibroblast cos cell liver myofibroblast lx homotyp tumor hepb spheroid investig seed densiti cell l media success yield huhco heterotyp spheroid display steadi increas size cultur day follow growth retard find corrobor use hepb homotyp spheroid cultur lx human hepat stellat cell line condit medium cm lx cm trigger prolifer hepb spheroid compar control tumor spheroid conclus protocol shown tumor spheroid use simpl econom prescreen vitro tool studi tumor stromal interact comprehens | D006528;D008113 | T191 |
34,661,570 | burn injuri induc pain depress like behavior mice scald water common caus burn injuri elder young popul one major clinic challeng high mortal sequela low middl incom countri burn frequent induc intens spontan pain persist allodynia well life threaten problem import excess pain often accompani depress may signific decreas qualiti life articl show develop anim model studi burn induc pain depress like behavior anesthesia burn injuri induc dip one hind paw mous hot water c c von frey test autom gait analysi perform everi day burn injuri addit depress like behavior examin use forc swim test rota rod test perform differenti abnorm motor function burn injuri main purpos studi describ develop anim model studi burn injuri induc pain depress like behavior mice | D002056;D011788 | T037;T078 |
34,661,569 | isol select entomopathogen fungi soil sampl evalu fungal virul insect pest entomopathogen fungi epf one microbi control agent integr pest manag control local invas pest import isol select indigen epf therefor soil bait method combin insect bait mealworm tenebrio molitor system use studi modif isol epf subject virul test agricultur pest spodoptera litura furthermor potenti epf strain subject morpholog molecular identif addit conidia product thermotoler assay perform promis epf strain compar data substitut formula effect conidia number ecn laboratori rank soil bait mealworm system ecn formula improv replac insect speci integr stress factor evalu commerci field applic protocol provid quick effici approach epf select improv research biolog control agent | D005658;D007313 | T004;T204 |
34,661,568 | multiphoton intravit imag monitor leukocyt recruit arteriogenesi murin hindlimb model arteriogenesi strong depend leukocyt platelet recruit perivascular space grow collater vessel standard approach analyz collater arteri leukocyt arteriogenesi ex vivo immuno histolog methodolog howev techniqu allow measur dynam process blood flow shear stress cell cell interact particl veloc paper present protocol monitor vivo process grow collater arteri arteriogenesi util intravit imag method describ reliabl tool dynam measur offer high contrast analysi minim photo cytotox provid multiphoton excit microscopi prior analyz grow collater arteri arteriogenesi induc adductor muscl mice unilater ligat femor arteri ligat preexist collater arteri start grow due increas shear stress twenti four hour surgeri skin subcutan fat collater arteri remov construct pocket analys visual blood flow immun cell vivo imag cd fluorescein isothiocyan fitc platelet cd phycoerythrin pe leukocyt antibodi inject intraven iv via cathet place tail vein mous articl introduc intravit multiphoton imag altern vivo complement common use static ex vivo immuno histolog analys studi process relev arteriogenesi summari paper describ novel dynam vivo method investig immun cell traffick blood flow shear stress hindlimb model arteriogenesi enhanc evalu possibl notabl | D007962;D018919 | T025;T039 |
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