PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
|---|---|---|---|
34,662,121 | target deliveri site specif activ cyclodextrin conjug photosensit photodynam therapi supramolecular bio orthogon approach target deliveri photosensit use hydrophil tumor direct carrier site specif activ photocytotox two common strategi enhanc specif anticanc photodynam therapi report herein novel supramolecular bio orthogon approach integr two function cyclodextrin substitut aza boron dipyrromethen base photosensit first complex ferrocen substitut black hole quencher inhibit photosensit abil upon encount adamantan moieti deliv target cancer cell specif bind conjug peptid overexpress epiderm growth factor receptor ferrocen base guest speci displac due stronger bind interact cyclodextrin adamantan therebi restor photodynam activ photosensit henc two step process enabl target deliveri site specif activ photosensit demonstr seri experi aqueous media rang cancer cell line tumor bear nude mice | D010778 | T061 |
34,662,119 | transit metal free transfer hydrogen cascad reaction nitroaren aminesalcohol redox econom access benzimidazol report describ effici transit metal free process toward transfer hydrogen cascad reaction nitroaren amin alcohol develop redox econom approach realiz use combin ko bu et sih reagent allow synthesi benzimidazol deriv via bond metathesi reaction condit hold well wide rang substrat embed divers function group deliv desir product good excel yield mechanist propos depict basi seri control experi mass spectroscop evid well support densiti function theori dft calcul feasibl energi profil | D000438;D028561 | T196;T121;T109 |
34,662,117 | toolbox distal c h bond function organ molecul transit metal catalyz c h activ develop contemporari approach omnipres area retrosynthet disconnect scientif research tempt take help methodolog plan synthet discours paradigm shift help develop industri unit well make synthesi natur product pharmaceut drug step econom vast zone c h bond activ function proxim c h bond gain utmost popular unlik activ proxim c h bond distal c h function strenuous requir distinct special techniqu review compil various method adopt function distal c h bond mechanist insight within procedur scope methodolog review give complet overview expediti progress distal c h activ made field synthet organ chemistri also highlight pitfal thus leav field open synthet modif | D001688;D028561 | T121;T196;T123 |
34,662,116 | prospect select mechan emerg senolyt agent deriv flavonoid senesc cell scs associ onset develop multipl chronic diseas select clearanc scs senolyt drug potenti therapeut option number age relat diseas among senolyt candid dasatinib quercetin fisetin meet rigor criteria senolyt drug accord modifi version koch postul astonish two three agent ie quercetin fisetin flavonoid although mechan preferenti elimin scs unclear herein propos possibl select mechan prooxid activ quercetin fisetin inevit involv kill apoptosi resist scs among dietari flavonoid quercetin potent redox activ flavonoid strong prooxid activ transit metal copper iron huge amplifi prooxid activ fisetin higher senolyt activ quercetin higher prooxid effect quercetin absenc presenc copper appear prooxid activ flavonoid import consider screen senolyt scs accumul high level copper iron select mechan quercetin fisetin probabl associ copperiron promot oxid damag scs copper iron dramat enhanc prooxid effect flavonoid epigallocatechin gallat shown deplet effect scs rat high therapeut efficaci patient idiopath pulmonari fibrosi larg caus scs investig evalu whether epigallocatechin gallat senolyt drug accord koch postul warrant | D016922;D005419 | T043;T127;T121;T109 |
34,662,115 | determin droplet bound free gas phase fragranc use filter incorpor needl trap devic solid phase microextract technolog fragranc compound aerosol tend remain trap insid droplet abil captur droplet would make possibl desorb transfer analyt dissolv within determin studi design novel filter incorpor needl trap devic use captur fragranc compound droplet well gas phase seven aerosol spray sampl comparison thin film solid phase microextract also employ extract gas phase born fragranc spray result reveal filter incorpor needl trap devic enabl extract total concentr due abil trap fragranc contain droplet wherea thin film solid phase microextract abl extract unbound compound present gas phase addit develop needl trap devic provid accept result prove applic analysi aroma sampl beer soda | D009812;D052617 | T070;T120;T059 |
34,662,114 | function hybrid micronanoent promot agro food safeti inspect rapid develop nanomateri provid good theoret basi technic support solv problem food safeti inspect combin function composit nanomateri well known detect method gradual appli detect hazard substanc chemic residu toxin agricultur food product review concentr latest agro food safeti inspect techniqu methodolog construct assist new hybrid micronanoent molecular imprint polym integr quantum dot mip qds molecular imprint polym integr upconvers luminesc nanoparticl mip ucnp upconvers luminesc nanoparticl combin metal organ framework ucnp mof magnet metal organ framework mof fe magnet coval organ framework fe cof coval organ framework dope quantum dot cof qds nanobodi involv immunoassay fast inspect etc present summari discuss favor relev outlook integr various disciplin like materi scienc nanotechnolog analyt methodolog address new challeng emerg agro food research field | D000073396;D054802;D049329;D045663 | T073;T063;T109 |
34,662,113 | extrem sensit molecular imprint ecl sensor multipl probe releas liposom immobil light trigger click reaction molecular imprint electrochemiluminesc sensor prepar sensit select determin aminotriazol via novel strategi multipl ru bpi cl probe releas liposom immobil light trigger click reaction sens strategi provid platform trace detect amino contain pesticid target molecular imprint membran connect ru bpi cl encapsul liposom via click reaction destabil agent triton x ad numer ru bpi cl molecul releas liposom molecular imprint polym electrod ecl respons sensor linear proport logarithm aminotriazol concentr rang moll detect limit moll sensit detect signific improv analysi process simplifi | D008081;D008163 | T059;T109 |
34,662,108 | larg inter intraspeci variabl polyphenol proanthocyanidin eight temper forag speci indic potenti exploit nutraceut substanti effort made incorpor tannin rich forag grassland base livestock product system howev structur function divers tannin differ speci limit potenti use field scale conduct greenhous experi cultivar forag speci cultivar ultraperform liquid chromatographi tandem mass spectrometri use analyz polyphenol profil proanthocyanidin pa structur featur leav result highlight larg inter intraspeci variabl plant term polyphenol tannin concentr leav concomit signific variat also regist structur featur pa rich forag mean degre polymer prodelphinidin percentag concentr pa also vari within plant organ highest concentr flower leav highest contribut harvest pa biomass research highlight identifi variat help identifi repres bioactiv provid basi target breed program | D044945 | T121;T109 |
34,662,106 | benchmark machin learn model polym informat exampl glass transit temperatur field polym informat util machin learn ml techniqu evalu glass transit temperatur g properti polym attract extens attent data centric approach much effici practic labori experiment measur encount daunt number polym structur various ml model demonstr perform well g predict nevertheless train differ data set use differ structur represent base differ featur engin method thus critic question aris select proper ml model better handl g predict general abil provid fair comparison differ ml techniqu examin key factor affect model perform carri systemat benchmark studi compil differ ml model train larg divers data set three major compon set ml model structur represent featur represent ml algorithm term polym structur represent consid polym monom repeat unit oligom longer chain structur base featur represent calcul includ morgan fingerprint without substructur frequenc rdkit descriptor molecular embed molecular graph etc afterward obtain featur input train use differ ml algorithm deep neural network convolut neural network random forest support vector machin lasso regress gaussian process regress evalu perform ml model use holdout test set extra unlabel data set high throughput molecular dynam simul ml model general abil unlabel data set especi focus model sensit topolog molecular weight polym also taken consider benchmark studi provid guidelin g predict task also use refer polym informat task | D019985;D011108 | T104;T122;T081 |
34,662,105 | engin cis element saccharomyc cerevisia effici accumul valu ad compound squalen via downregul downstream metabol flux transcript downregul wide use metabol flux control maro cis element escherichia coli mar oper explor engin promot saccharomyc cerevisia downregul first adh promot p adh enhanc variant p uadh engin insert maro differ site result decreas gfp transcript gfp fluoresc intens various degre maro appli engin nativ erg erg promot due import accumul valu ad intermedi squalen lanosterol elev squalen content fold lanosterol content fold decreas ergosterol content result maro engin promot p erg p erg respect indic valid maro engin promot metabol flux control furthermor squalen product gl cane molass cheap bulk substrat suggest cost effect promis potenti squalen product | D012441;D029701 | T004;T116 |
34,662,102 | tumuc new accur dna forc field consist high level quantum chemistri accur molecular mechan forc field form basi molecular dynam simul obtain realist view structur dynam biomolecul dna although frequent updat improv agreement avail experiment data dna forc field still reli part paramet introduc year ago develop entir new dna forc field tumuc deriv quantum mechan calcul obtain consist set bond paramet partial atom charg perform forc field extens test varieti dna molecul excel accuraci b dna simul also perform well type dna structur structur format process hairpin fold duplex format dynam dna protein complex complement exist forc field order provid increas accur descript structur dynam dna simul studi | D056004 | T044;T066 |
34,662,098 | bioinspir heterobimetal photocatalyst ruiichrom feiiicat visibl light driven c h oxid organ substrat via dioxygen activ report bioinspir heterobimetal photocatalyst ru ii chrom fe iii cat relev applic toward visibl light driven c h bond oxid seri hydrocarbon use atom sourc ru ii center absorb visibl light near nm trigger cascad electron fe iii afford catalyt activ high valent fe iv speci situ form fe iv employ sever high impact oxid reaction presenc triethanolamin teoa sacrifici electron donor | D010100 | T121;T196;T123 |
34,662,096 | quaternari ammonium compound bioaccumul potenti human level blood covid pandem quaternari ammonium compound qac common use varieti consum pharmaceut medic product studi bioaccumul potenti qac alkyl chain length c c determin vitro vivo extrapol iviv model use result human hepat metabol serum protein bind experi slowest vivo clearanc rate estim c qac suggest compound may preferenti build blood bioaccumul qac confirm analysi human blood sera sampl n fifteen target qac detect blood qac concentr reach ngml blood sampl collect two distinct time period outbreak covid pandem n pandem n qac concentr signific higher sampl collect pandem median ngml collect median ngml first comprehens studi bioaccumul biomonitor three major qac group result provid valuabl inform futur epidemiolog toxicolog risk assess studi target chemic | D000086382;D004202 | T167;T131;T047;T067 |
34,662,095 | introduc hyaluron acid supramolecular polym hydrogel use supramolecular polym construct function biomateri gain attent due tunabl dynam behavior fibrous structur supramolecular polym resembl found natur system extracellular matrix nevertheless obtain biomateri capabl mimick nativ system complex biomolecul incorpor allow one achiev essenti biolog process studi supramolecular polym base water solubl benzen tricarboxamid btas assembl presenc hyaluron acid ha solut hydrogel state coassembl btas bear tetra ethylen glycol peripheri bta oeg ha differ ratio show strong interact two compon led format short fiber heterogen hydrogel btas coval link ha ha bta result polym unabl assembl fiber form hydrogel due high hydrophil ha howev coassembl ha bta bta oeg result format long fiber similar form bta oeg alon hydrogel produc tunabl stiff rang pa fold higher hydrogel assembl bta oeg coassembl bta oeg fiber polysaccharid show except dextran polysaccharid studi interact bta oeg fiber possibl incorpor polysaccharid bta base materi pave way creation dynam complex biomateri | D006820;D020100 | T121;T122;T109;T123 |
34,662,006 | surgic explant fail transcathet aortic valv transcathet aortic valv replac increas util younger lower risk popul expect see larger number patient present structur deterior aortic valv replac transcathet rout requir explant surgic replac surgic aortic valv replac transcathet aortic valv replac associ oper morbid mortal rate signific higher seen set surgic replac nativ valv day mortal recent seri center perform transcathet aortic valv replac lower risk patient longer expect lifespan higher probabl late structur deterior transcathet aortic valv replac care consid choic valv type balloon expand versus self expand patient anatomi includ annulus root diamet time initi valv intervent one forget mechan surgic aortic valv replac option younger patient risk factor earli structur valv deterior obes metabol syndrom chronic kidney diseas object tutori describ preoper workup patient late structur valv deterior transcathet aortic valv replac detail explant approach specif self expand valv illustr key decis techniqu need subsequ surgic aortic valv replac | D001024;D006350;D065467 | T074;T047;T061 |
34,662,005 | sternal spare bilater symmetr thoracotomi implant left ventricular assist devic reopen chest patient left ventricular assist devic time heart transplant challeng due adhes possibl injuri vital structur sternal spare bilater thoracotomi approach util implant left ventricular assist devic minim chanc injuri offer cosmet better outcom demonstr procedur implant left ventricular assist devic year old man diagnos dilat cardiomyopathi suffer rapid decompens despit maximum medic therapi | D006333;D006353 | T074;T047;T046 |
34,662,004 | video assist thoracoscop parenchym spare rotat bronchoplasti manag bronchial carcinoid tumor present modifi bronchoplasti techniqu involv rotat bronchial structur goal reconstruct bronchus without use foreign materi fulli preserv parenchyma use biport vat approach central locat bronchial tumor junctur right main bronchus right upper lobe bronchus bronchus intermedius first resect right upper lobe bronchus rotat caudal toward bronchus intermedius togeth slight clockwis rotat posterior facilit approxim tension free closur bronchial defect video tutori demonstr oper step explain rotat aspect achiev | D001984;D002276;D019651 | T191;T061 |
34,662,003 | blunt aortic injuri surgic treatment ascend descend aorta traumat aortic injuri potenti fatal although uncommon involv aortic arch ascend aorta occur case show concomit dissect ascend descend section aorta blunt chest trauma open surgic approach success perform treat aortic injuri | D017545;D001018;D019917;D013898;D014949 | T037;T047;T061 |
34,662,002 | five box thoracoscop maze base gemini bipolar ablat devic treat atrial fibril thoracoscop atrial fibril ablat seek replic electrophysiolog effect invas open surgic procedur author present lesion concept includ isol pulmonari vein left atrial posterior wall superior vena cava respect line inhibit perimitr periauricular flutter circuit left atrial appendag closur lesion test bidirect block | D001281;D017115;D011667 | T023;T047;T061;T046 |
34,662,001 | uniport thoracoscop later posterior segmentectomi use modifi intersegment tunnel procedur later posterior basal segmentectomi one challeng oper requir exposur recognit pulmonari vessel branch bronchi locat deep lung parenchyma perform difficult oper appropri even via uniport approach adopt modifi version intersegment tunnel procedur intersegment tunnel follow divis intersegment plane perform divis modifi version addit clear recognit domin vessel bronchi permit tunnel procedur abl divid smooth use stapler modifi version although tip insert stapler stuck lung parenchyma previous version method might univers prefer even less experienc surgeon perform challeng oper | D008175;D011013 | T191;T061 |
34,662,000 | efficaci vitamin b adjunct therapi lithium improv symptom acut mania patient bipolar disord type doubl blind random placebo control clinic trial vitamin b link varieti probabl role includ anti inflammatori homocystein lower serotonin regul dopamin lower studi investig possibl effect vitamin b bipolar disord manic episod psychot featur placebo control doubl blind clinic trial psychiatr hospit | D001714;D008094 | T048;T121;T196 |
34,661,999 | effect somat treatment suicid ideat complet suicid work undertaken defin character role current avail somat treatment psychiatri either increas reduc risk suicid | D012559;D000081013 | T048 |
34,661,997 | acut porphyria neurolog perspect acut hepat porphyria ahp caus sever neurolog symptom involv central autonom peripher nervous system due relat rariti chameleon like present delay diagnosi misdiagnosi common ahp genet inherit disord result heme biosynthesi enzym defici compris four form acut intermitt porphyria aip varieg porphyria vp hereditari coproporphyria hcp ala dehydratas porphyria aladp depend clinic present main differenti diagnos guillain barr syndrom autoimmun enceph red flag could rais suspicion acut porphyria neurolog symptom start sever abdomin pain associ reddish urin hyponatremia photodermat presenc encephalopathi andor axon neuropathi highlight diagnost difficulti present three case neurolog intens care unit give comprehens overview diagnost find imag electrophysiolog neuropatholog | D009422;D017118;D011164;D017094 | T047 |
34,661,996 | predictor activ daili live heathi older adult benefit onlin cognit train investig cours activ daili live iadl function possibl predictor perform chang healthi older adult conduct either general cognit train gct reason cognit train react train control group cg period week month month | D000203;D003072 | T080;T048;T056 |
34,661,995 | interact influenc emot extravers visual attent emot shown influenc select visual attent howev studi field reveal contradictori find regard natur influenc one possibl explan variat find affect inter individu differ impact attent emot may therefor moder influenc emot attent current work novel investig effect induc emot state trait extravers neurotic visual attent allow direct investig impact extravers neurotic way emot influenc attent | D004644;D005120 | T041 |
34,661,994 | real time vivo measur protein kinas activ deep brain structur use fluoresc lifetim photometri flip biochem state neuron cell general regul extracellular factor includ neurotransmitt neuromodul growth hormon interact anim environ trigger neuromodul releas engag biochem transduct cascad modul synaps cell function although process thought enact behavior adapt chang environ brain induc mysteri challeng monitor biochem state real time defin neuron behav anim describ method allow measur activ protein kinas pka import intracellular effector neuromodul freeli move mice monitor pka activ vivo use genet target sensor flim akar fluoresc lifetim photometri flip articl describ set flip system obtain robust record net pka phosphoryl state vivo method general use monitor pathway fluoresc lifetim report exist wiley period llc basic protocol build flip system basic protocol flim akar viral inject fiber implant flip measur basic protocol perform measur use flip | D001921;D010783 | T023;T059 |
34,661,993 | measur amyloid peptid concentr murin brain improv elisa assay amyloid peptid amino acid implic alzheim diseas may potenti aggreg toxic oligom form neurit plaqu enzym link immunosorb assay elisa facil method use determin concentr biolog matric name plasma cerebrospin fluid brain method most use measur concentr transgen mice unknown whether elisa method suitabl measur low endogen level brain wild type mice elisa kit manufactur recommend use guanidin hydrochlorid guhcl protein denatur agent homogen brain tissu follow dilut back avoid quench guhcl compon brain matric guhcl could interfer quantit investig articl describ improv method involv homogen mous brain instead guhcl reduc dilut factor provid higher sensit modifi elisa assay improv quantit brain peptid wild type mice peptid level much lower transgen mous model wiley period llc | D016229;D058225 | T116;T020 |
34,661,991 | probabilist boolean model pre clinic tumor model biomark identif cancer drug develop high throughput sequenc experi becom wide use pre clinic clinic set pharmacogenet pharmacogenom biomark develop play increas import role oncolog drug develop pipelin program consequ comput base learn approach enter use multipl stage pre clinic clinic pipelin howev approach avail identifi interpret implement biomark respons earli drug develop process small pre clinic data packag avail address need earli stage biomark develop use pre clinic tumor model adapt previous publish probabilist target inhibitor map ptim platform challeng biomark hypothesi develop denot approach probabilist target map biomark ptm biomark articl detail histori design philosophi ptm biomark present two case studi use biomark discoveri tool illustr util guid cancer drug develop wiley period llc | D000970;D009369 | T191;T121;T109 |
34,661,990 | comprehens analyt empir evalu genom predict across divers access maiz effici exploit natur genet divers captur access store genebank crucial genet improv major crop select access interest genebank tradit requir inform extens expens evalu howev low cost genotyp combin genom predict enabl us generat predict genet merit entir set target phenotyp evalu repres subset explor general approach analyt assess empir valid maiz zea may l associ popul map train popul conduct present studi cross valid within map reveal most modest strong predict abil trait general parallel squar root herit map use train predict model generat genom estim breed valu gebv ame divers panel empir valid conduct nine trait across two valid popul confirm accuraci level indic cross valid train popul upper bound reliabl u valu calcul access predict popul use genotyp data group access high u valu general high predict abil even though rang observ trait valu similar group access low u valu comprehens analysi valid general approach turbocharg genebank genom genom predict addit breeder research consid gebv u valu balanc need improv specif trait broaden genet divers select access genebank | D000069600;D003313 | T040;T002;T168 |
34,661,989 | high preval epilepsi northern rwanda explor gender differ sub saharan africa ssa preval lifetim epilepsi vari wide subregion higher rural compar urban region observ versus expect number patient epilepsi pwe northern provinc rwanda match preval report rwanda report confirmatori preval studi focus gender specif observ | D004827 | T033;T047 |
34,661,988 | trigemin neuropathi two case report gasserian ganglion stimul report describ success treatment two patient trigemin neuropathi use gasserian ganglion stimul case report first case report deal year old woman suffer right side facial pain gamma knife lesion schwannoma right inner ear year sever intervent aim reliev pain unsuccess fact aggrav symptom trial neurostimul level gasser ganglion immedi posit effect score facial pain decreas visual analog scale assess period month addit patient wean medic end period second case report describ year old man suffer trigemin neuropathi main manifest itch period year neither medic sever intervent effect trial electrod level gasser ganglion reduc pain score visual analog scale assess period three month medic could limit pregabalin mg bidaili contrast prior implant oral medic consist pregabalin mg five time day conclus case report show stimul gasserian ganglion success minim invas non destruct treatment refractori trigemin neuropathi consid earlier treatment algorithm trigemin neuropathi | D020433;D014277 | T047 |
34,661,987 | cross cultur preval sleep qualiti psycholog distress healthcar worker covid pandem poor qualiti sleep emot disturb expect time crisi covid sever impact healthcar worldwid come concern effect healthcar worker purpos present studi assess sleep qualiti psycholog distress healthcar worker covid pandem | D000086382;D000079225 | T048;T047;T067 |
34,661,986 | genet loci associ winter survivorship divers lowland switchgrass popul high winter mortal limit biomass yield lowland switchgrass panicum virgatum l plant northern latitud north america breed cold toler switchgrass cultivar requir mani year due perenni growth habit unpredict winter select pressur requir identifi winter hardi individu identif causal genet variant winter survivorship would acceler improv switchgrass biomass product object studi identifi allel variat associ winter survivorship lowland switchgrass popul use bulk segreg analysi bsa twenti nine lowland switchgrass popul evalu winter surviv two locat southern wisconsin popul differenti winter survivorship use bsa maximum individu bulk creat survivor nonsurvivor dna pool popul locat dna pool evalu use exom captur sequenc allel frequenc use conduct statist test bsa test reveal nine quatit trait loci qtl tetraploid popul seven qtl octoploid popul mani qtl popul specif identifi multipl popul origin across broad geograph landscap four qtl posit mb chromosom n mb chromosom k mb chromosom n potenti use qtl marker associ winter survivorship studi use acceler breed cycl lowland switchgrass popul lead improv adapt within usda hardi zone | D008897 | T002 |
34,661,985 | protect mechan foxo earli brain injuri subarachnoid hemorrhag regul autophagi earli brain injuri ebi play key role devast outcom subarachnoid hemorrhag sah autophagi apoptosi may share common molecular induc regul process cell death foxo key regul neuron autophagi involv apoptosi report sah rat work investig protect anti inflammatori effect foxo ebi sah regul autophagi | D001929;D001930;D018696;D013345 | T047;T121;T046;T169;T037 |
34,661,982 | oxytocin receptor polymorph influenc character harm avoid moder suscept affectionless control parent oxytocin receptor oxtr gene polymorph report moder effect negat environ childhood mental function behavior depress symptom extern problem studi examin oxtr gene polymorph effect person trait healthi particip consid interact effect polymorph affectionless control ac parent one dysfunct pathogen parent style | D016487;D018045 | T192;T116;T054 |
34,661,981 | stress cope resili sleep covid pandem repres survey studi us adult covid pandem global health emerg result widespread death substanti disrupt daili life previous research shown novel diseas outbreak associ high stress level sleep impair lead neuropsychiatr consequ therefor vital studi stress protect factor cope resili may hinder help sleep qualiti covid pandem gender dispar exist sleep qualiti import understand relationship pandem relat stress cope strategi resili sleep bothgend covid pandem | D000086382;D058873 | T047;T067 |
34,661,980 | correl studi onlin friendship network internet game disord among univers student purpos studi provid basic inform analysi correl onlin friendship network internet game disord among univers student | D016739;D018910 | T048;T073 |
34,661,978 | shunt complic revis children retrospect singl institut studi shunt surgeri children associ high revis complic rate investig revis rate postop complic specifi current challeng associ pediatr shunt surgeri | D006849;D017287 | T033;T047;T019;T061 |
34,661,976 | dataset comput reaction barrier claisen rearrang chemic numer analysi theoret reaction screen base gibb energi barrier would promis acceler chemic reaction mine number quantum chemic calcul reduc use optim algorithm genet algorithm ga bayesian optim bo focus studi generat dataset reaction barrier size dataset would use quick evalu various implement optim algorithm ga bo dataset includ gibb energi barrier claisen rearrang molecul comput basi semiempir theori pm evalu chemic numer featur found dataset well reflect chemic trend various substitut use test various implement optim algorithm dataset avail supplementari materi paper | D001499 | T081 |
34,661,975 | lymph node fna cytolog diagnost perform clinic implic propos diagnost categori despit widespread clinic use lymph node fine needl aspir cytolog ln fnac lack univers accept definit diagnos lymphoma like due report lower diagnost perform inconsist terminolog use cytopatholog diagnost report limit data clinic implic ln fnac diagnos recent uniform ln fnac cytopatholog diagnost report system propos sydney system studi evalu ln fnac diagnost perform risk malign associ propos diagnost categori | D009369 | T191 |
34,661,974 | cell cell type type heterogen signal network insight crowd recent technolog develop allow us measur status dozen protein individu cell open way understand heterogen complex multi signal network across cell cell type import implic understand treat diseas cancer technolog howev limit protein antibodi avail fair cost make predict new marker exist marker new condit valuabl altern assess capac make predict boost methodolog develop organ singl cell signal breast cancer dream challeng use mass cytometri dataset cover marker condit total million singl cell across breast cancer cell line four increas difficult subchalleng particip predict miss marker new condit time cours respons singl cell stimuli presenc absenc kinas inhibitor challeng result show despit stochast natur signal transduct singl cell signal event tight control machin learn method accur predict new experiment data | D001943;D015398 | T043;T044;T191 |
34,661,973 | use endoscop ultrasound guid biliari drainag rescu intervent placement multipl metal stent malign hilar biliari obstruct endoscop transpapillari intervent etp ri multipl self expand metal stent sem placement unresect malign hilar biliari obstruct mhbo challeng endoscop ultrasound guid biliari drainag eus bd could altern follow fail etp ri investig appropri intervent ri method mhbo multipl sem placement evalu ri eus bd eus ri benefit follow etp ri failur | D002779;D010195 | T047;T046 |
34,661,971 | multi centric studi valid fear scale covid five arab speak countri eight item fear scale unidimension scale evalu perceiv feel fear associ thought coronavirus | D000086382 | T047;T067 |
34,661,968 | novel nanohybrid effervesc enhanc magnet solid phase microextract wide polar organ pollut roast meat sampl simultan effici extract pollut differenti polar herein fabric character multifunct nanocomposit novel nanohybrid use nife magnet core nh mil al cyclodextrin graphen oxid function compon combin magnet core aid graphen oxid larg conjug system nh mil al strong adsorpt moderatelystrong polar chemic cyclodextrin specif recognit effect nanohybrid realiz synergist effici extract polyaromat hydrocarbon bisphenol log kow rang combin acid alkalin sourc nanohybrid base effervesc tablet prepar base effervesc reaction enhanc nanohybrid base effici adsorptionextract high perform liquid chromatographi fluoresc detect success develop excel microextract method simultan determin polyaromat hydrocarbon bisphenol roast meat sampl sever import variabl optim follow na co tartar acid acid alkalin sourc lof mix solvent aceton hexan vv eluent min elut time optim condit novel method gave low limit detect g kg satisfactori recoveri high precis relat standard deviat roast lamb beef pork chicken sausag sampl | D008280;D049329 | T073;T090 |
34,661,967 | vivo sens cutan edema compar studi diffus reflect raman spectroscopi multispectr imag quantit noninvas assess water content tissu import biomedicin optic spectroscopi potenti capabl solv problem howev applic clinic diagnost remain question present studi compar diffus reflect spectroscopi raman spectroscopi multispectr imag character cutan edema sourc detector geometri method select base mont carlo simul result detect signal dermi kinet edema develop studi two model method demonstr synchron trend histamin induc edema water content reach maximum hour histamin applic gradual decreas venous occlus increas water content observ raman spectroscopi differ water content estim three method explain base light propag model obtain result essenti introduc quantit optic water measur technolog clinic | D004487;D013059 | T070;T046;T059 |
34,661,965 | differenti frontal fibros alopecia lichen planopilari trichoscopi comprehens review trichoscopi dermatolog open new concept overcom optic challeng face clinic reveal diagnost detail depth superfici dermi therebi increas clinician diagnost accuraci level confid import trichoscopi cicatrici alopecia evid current scenario precis diagnosi clinic pictur delin lichen planopilari lpp frontal fibros alopecia ffa also close mimick androgenet alopecia alopecia areata femal pattern hair loss cicatrici alopecia bewild due vari present co exist diseas indecis compar find histopatholog make situat even perplex articl review characterist trichoscopi pattern differenti lpp ffa close mimick | D000506;D008010 | T047 |
34,661,964 | model impact hiv hcv prevent treatment intervent peopl inject drug dar es salaam tanzania peopl inject drug pwid dar es salaam tanzania high preval hiv hepat c virus hcv needl syring programm nsp opioid agonist therapi oat anti retrovir therapi art avail tanzania coverag sub optim assess impact exist scale harm reduct hr intervent hiv hcv transmiss among pwid dar es salaam | D015658;D006526;D004364;D015819 | T048;T047;T121 |
34,661,963 | cdc borg septin axi regul hsc polar function age hematopoiet stem cell hscs caus elev activ small rhogtpas cdc apolar distribut protein mechan cdc activ control polar hscs known binder rhogtpas protein borg known effector protein cdc abl regul cytoskelet septin network show cdc interact borg turn interact septin regul polar distribut cdc borg septin within hscs genet delet either borg septin result reduc frequenc hscs polar cdc borg septin reduc engraft potenti decreas lymphoid prime multipot progenitor lmpp frequenc bone marrow taken togeth data identifi cdc borg septin axi essenti mainten polar within hscs hsc function provid rational investig role borg septin regul compartment within stem cell | D003598;D006412;D058112;D020741 | T025;T116;T126;T123 |
34,661,962 | tanshinon iia inhibit gastric cancer cell stem induc ferroptosi tanshinon iia activ constitu extract salvia miltiorrhza numer studi shown tanshinon iia could inhibit tumor prolifer metastasi includ gastric cancer howev effect tanshinon iia gastric cancer cell stem stay unclear found tanshinon iia could reduc gastric cancer cell stem detect spheroid form flow cytometri analysi express stem marker oct aldha cd mechanist tanshinon iia increas level lipid peroxid decreas glutathion level gastric cancer cell marker ferroptosi similar ferroptosi induc erastin sulfasalazin sorafenib reduc gastric cancer cell stem addit inhibitori effect tanshinon iia gc cell stem revers ferroptosi inhibitor fer overexpress slca critic ferroptosi inhibitor therefor reveal tanshinon iia inhibit stem gastric cancer cell part induc ferroptosi | D000972;D000079403;D013274 | T043;T191;T121 |
34,661,961 | recent advanc stereocontrol mannosyl focus glycan compris acid andor amino sugar main focus review describ accomplish made stereoselect synthesi link mannosid function carboxyl aminesamid mannac mana mannaca residu found mani glycoconjug bacteri polysaccharid algin consist captur interest glycosci communiti due synthet challeng therapeut potenti | D000606;D009844 | T109;T123 |
34,661,960 | feasibl two robot singl site surgeri techniqu adolesc endometriosi focal versus butterfli studi examin feasibl robot laparoendoscop singl site surgeri less treatment adolesc endometriosi n addit assess novel techniqu known butterfli resect sever case | D004715;D010535;D065287 | T061;T191;T047;T060 |
34,661,959 | print scaffold monolith aerogel photocatalyst complex geometri monolith aerogel compos crystallin nanoparticl enabl photocatalysi three dimens suffer low mechan stabil difficult produc complex geometri approach control geometri photocatalyst optim photocatalyt perform introduc care design print polymer scaffold aerogel monolith report allow systemat studi improv fundament paramet gas phase photocatalysi gas flow ultraviolet light penetr aerogel custom geometr shape continu gas flow reactor use photocatalyt methanol reform model reaction shown optim paramet lead increas hydrogen product rate factor three mol g h rigid scaffold also enhanc mechan stabil aerogel lower number reject synthesi facilit handl oper combin nanoparticl base aerogel print polymer scaffold open new opportun tailor geometri photocatalyst photocatalyt reaction reactor maxim overal perform without necessarili chang materi composit | D053758 | T073 |
34,661,958 | surviv morbid outcom pelvic exenter pelvic sarcoma institut seri describ institut experi manag local advanc primari recurr pelvic sarcoma pelvic exenter pe | D010385;D010386;D012004;D012509 | T191;T061 |
34,661,956 | machin learn model classifi dynam process liquid water dynam water molecul play vital role understand water combin comput simul deep learn studi dynam h bond water molecul base ab initio molecular dynam simul newli defin direct hydrogen h bond popul oper studi typic dynam process bulk water interchang h bond donor revers role acceptor design recurr neural network base model success classifi interchang breakag process water found ratio approxim hard depend temperatur k work impli deep learn great potenti help distinguish complex dynam process contain h bond system | D056004;D014867 | T044;T066;T121;T197 |
34,661,955 | studi co infect children sever communiti acquir pneumonia pneumonia one lead caus death children year old virus histor common caus communiti acquir pneumonia children co infect sever pneumonia concern clinician | D060085;D017714;D011014;D018410 | T047;T050 |
34,661,954 | splenectomi primari immun thrombocytopenia revisit era thrombopoietin receptor agonist new insight old treatment although splenectomi still consid effect curat treatment immun thrombocytopenia itp use signific declin last decad especi sinc approv thrombopoietin receptor agonist tpo ras main object studi determin whether splenectomi still effect nowaday particular patient failur respond tpo ras secondari object assess among patient relaps splenectomi pattern respons treatment use splenectomi multicent retrospect studi involv adult underw splenectomi itp franc respons status defin accord intern criteria includ patient patient receiv tpo ras andor rituximab splenectomi median follow splenectomi month overal patient initi respons experienc relaps follow overal sustain respons similar observ pre tpo ra era among patient receiv least one tpo ra rituximab splenectomi sustain respons six patient previous lack respons tpo ras rituximab sustain respons splenectomi among patient relaps splenectomi patient respond one tpo ras fail splenectomi conclus splenectomi still relev option treat adult primari itp respond tpo ras rituximab patient lack respons relaps splenectomi challeng tpo ras | D013156 | T061 |
34,661,952 | night night variabl sleep apnea detect cyclic variat heart rate long term continu ecg monitor sleep apnea common patient cardiovascular diseas factor worsen prognosi holter h ecg screen sleep apnea benefici care patient due high night night variabl sleep apnea lead misdiagnosi misclassif diseas sever | D002318;D012891 | T047 |
34,661,951 | rutaecarpin allevi acut pancreat mice arj cell suppress mapk nf b signal pathway via calcitonin gene relat peptid acut pancreat ap acut inflammatori condit pancrea previous studi shown rutaecarpin rut import alkaloid compon evodia rutaecarpa exhibit certain protect effect ap rat upregul calcitonin gene relat peptid cgrp howev molecular mechan rut ap remain unknown studi aim investig effect rut cerulein induc ap vivo vitro explor under molecular mechan ceruleinlp treat wild type mice cgrp gene knock mice rut signific amelior pancreat inflamm allevi histopatholog chang reduc il tnf level increas il level moreov rut improv ap suppress mapk nf b signal pathway effect most mediat cgrp cell base studi reveal rut signific improv cell viabil suppress apoptosi arj cell cerulein induc ap downregul il tnf stimul il releas inhibit mapk nf b stat signal activ cgrp depend manner rut amelior ceruleinlp induc ap inflammatori respons mice arj cell cgrp depend manner thus may repres potenti therapeut option ap patient studi provid valuabl insight ap drug develop | D016328;D010195 | T129;T047;T116;T046 |
34,661,950 | accuraci print digit cast produc intraor extraor scanner differ scan technolog vitro studi compar accuraci print digit cast produc various intraor extraor scanner differ scan technolog | D003761;D014070 | T023;T061 |
34,661,949 | japanes women reason accompani status hereditari breast ovarian cancer focus genet counsel genet counselor routin assess understand client need begin session attend genet counsel session without companion object sign genet counselor easili notic studi focus client reason accompani status genet counsel categor attend without companion questionnair survey interview conduct use snowbal sampl start chief execut offic ceo japanes hereditari breast ovarian cancer hboc support group particip continu depth interview answer questionnair five theme identifi interview person confid decis make style famili member habit time avail consider conflict famili member healthcar provid suggest data suggest client expect companion play certain role indic reason accompani status help genet counselor understand client famili motiv person habit psychosoci background high context cultur japan accompani status may help sign understand client true worri addit companion may futur client genet counsel due genet natur diseas conclus studi indic import genet counselor record accompani status initi genet counsel pay attent reason begin session may lead understand client psychosoci background facilit better client center genet counsel | D001943;D000072117;D010051 | T097;T191 |
34,661,947 | social prescript isol parent japan socioeconom characterist mother weak social connect communiti social connect mother import sound develop children prevent child maltreat understand attribut mother risk isol enabl communiti worker support vulner mother cross section studi aim identifi socioeconom predictor isol risk mother conduct japan decemb februari self administ questionnair includ social connect mother scale along matern age marit status employ status educ number children year child rear experi whether childcar kindergarten use famili structur year resid hous type famili financ level neighbourhood interact valid respons multipl regress analysi five socioeconom characterist associ mother low social connect standardis coeffici matern age p lack childcar kindergarten usag p poor famili financ p mother percept neighbourhood interact found poor p model take account effect famili financ score low highest level educ mother junior high high school mother percept neighbourhood interact signific predictor isol risk along matern age educ level financi comfort find give policymak communiti worker communiti leader insight import cultiv interact among neighbourhood communiti | D009035;D016487 | T092;T054;T099 |
34,661,944 | adhes barrier cardiac surgeri systemat review efficaci postop pericardi adhes associ increas morbid mortal surgic difficulti barrier exist limit adhes format yet littl known use cardiac surgeri studi present provid first major systemat review adhes barrier cardiac surgeri | D006348;D011183 | T046;T061 |
34,661,940 | diagnost yield microarray individu non syndrom development delay intellectu disabl intellectu disabl id development delay dd individu yet year age evid year age characteris signific limit intellectu function adapt behaviour iddd may clinic classifi syndrom non syndrom genom copi number variat cnvs constitut well establish aetiolog subgroup iddd overal diagnost yield microarray estim iddd especi higher particular clinic featur render condit syndrom accompani | D008607 | T048 |
34,661,937 | replac radiologist deep learn pigeon error trust medic ai sudden rise abil machin learn methodolog deep neural network identifi predict great accuraci instanc malign cell growth radiolog imag led promin develop technolog geoffrey hinton hold view stop train radiologist similar view exist context regard replac human artifici intellig ai technolog assumpt kind view deep neural network better human radiologist accur less cost predict power human counterpart paper argu consider even true simpli inadequ reason us alloc kind trust suggest hinton other sort artifact particular show consider true someth ai devic say pigeon would suffici reason trust way suggest deep neural network medic set case consider also insuffici trust ai enough replac radiologist furthermor argu reliabl ai methodolog deep neural network center argument someth yet establish face fundament challeng challeng possibl ascrib level reliabl expect deploy medic devic reason cite favor deploy ai technolog medic set sufficientadequ even true know whether true face non trivial epistem challeng good reason advoc replac radiologist ai methodolog deep neural network | D001185;D000077321 | T066;T073;T090 |
34,661,930 | sensit clinician assess efficaci outcom measur instrument trial topic therapi atop dermat systemat review meta analysi rise preval atop dermat ad develop countri substanti socioeconom impact further research last two decad give way advanc aetiopathogenesi treatment topic therapi target newli identifi ad signal pathway develop numer clinician assess diseas sever outcom measur instrument omi avail evalu efficaci investig treatment proof concept poc trial ad howev littl known compar sensit efficaci omi perform systemat review meta analysi compar sensit differ omi control trial topic therapi ad publish januari april treatment effect size omi report week calcul confid interv ci sensit omi compar pool standard differ mean cohen cohen h two omi paramet combin report studi identifi systemat review assess paramet differ activ vehicl week chang baselin cfb percentag chang baselin cfb week identifi total studi subject examin differ omi includ quantit meta analysi continu omi signific higher treatment effect size vs dichotom omi p comparison eczema area sever index easi investig global assess iga bodi surfac area bsa score atop dermat scorad avail paramet perform general similar sensit bsa show smaller overal effect size estim conclus continu omi use topic clinic trial ad signific higher treatment effect size compar dichotom omi continu omi could provid power poc trial small sampl size atop dermat topic therapi | D003876;D004485 | T047 |
34,661,927 | cutan find follow covid vaccin review world literatur experi grow evid novel coronavirus diseas covid also covid vaccin caus varieti skin reaction review articl provid brief overview cutan find observ sinc emerg mass covid vaccin campaign world unspecif inject site reaction earli occur vaccin frequent type hypersensit reaction eg urticaria angio oedema anaphylaxi like due allergi ingredi may rare occur sever type iv hypersensit reaction may observ includ delay larg local skin lesion covid arm inflammatori reaction dermal filler previous radiat site even old bcg scar common morbilliform erythema multiform like rash autoimmun mediat skin find covid vaccin includ leucocytoclast vascul lupus erythematosus immun thrombocytopenia function angiopathi chilblain like lesion erythromelalgia may also observ pityriasi rosea like rash reactiv herp zoster also report covid vaccin conclus numer cutan reaction pattern may occur follow covid vaccin wherebi mani skin find immunologicalautoimmunolog natur import molecular mimicri exist sar cov eg spike protein sequenc use design vaccin human compon may thus explain covid patholog well advers skin reaction covid vaccin | D000707;D000086382 | T047;T067;T046 |
34,661,926 | child best interest gamet donat procreat donor gamet widespread common accept involv ethic question child best interest understand histor structur moral discuss gamet donat may contribut reflect child best interest analys debat gamet donat netherland analysi uncov strike discontinu notion child best interest undergon radic swing past consid accept conceal truth child biolog origin past two decad general opinion chang common belief inform share child chang notion child best interest analys use framework encompass three view child deriv debat children right three view provid differ interpret child moral polit status conclud chang notion child best interest result view child focus autonomi citizenship frame child interest accord legal status comment view champion altern one name embed child relat view base care ethic goe beyond articul law help establish balanc interpret child best interest practic polici level gamet donat | D000087482;D005854 | T025;T078;T064 |
34,661,923 | util comorbid indic assess head neck surgeri outcom systemat review evalu util comorbid index ci score predict outcom head neck surgeri hns cis evalu charlson comorbid index cci elixhaus comorbid index eci kaplan feinstein index kfi american societi anesthesiologist physic status asa ps adult comorbid evalu ace nation cancer institut comorbid index nci ci washington univers head neck comorbid index wuhnci | D015897 | T033 |
34,661,921 | singl bubbl tube microextract coupl capillari electrophoresi headspac hs extract sampl pretreat techniqu volatil semivolatil organ compound complex matrix recent tube microextract itm coupl ce use acceptor plug place capillari inlet develop simpl power hs extract method present singl bubbl sb itm use bubbl hang capillari inlet immers sampl donor solut hs submicrolit volum nl analyt evapor bubbl extract acceptor phase capillari open electrophoresi enrich extract carri sinc bubbl volum much smaller convent hs volum ml fill evapor analyt rapid analyt could enrich much faster compar convent hs itm owe high surfac volum ratio sb min sb itm yield enrich factor valu similar min hs itm min sb itm room temperatur appli tap water sampl enrich factor trichlorophenol tcp tcp dichlorophenol respect loq obtain monitor absorb nm ppb much lower ppb world health organ guidelin maximum permiss concentr tcp drink water | D002733;D060766;D059627;D014874 | T167;T131;T059;T109 |
34,661,918 | satisfact connect implic strong relate model flourish coupl relationship central featur coupl relationship research use self report measur relationship satisfact despit widespread use measur coupl research scholar rais critic question satisfact focus assess includ concern take ontolog individualist focus move beyond ontolog individu draw strong relate model relationship flourish data coupl unit state canada n individu explor similar differ assess relationship satisfact measur base strong relate relat connect evalu associ scale assess relationship factor includ indic well relationship process virtu respons action use confirmatori latent profil analysi classifi individu flourish languish connect less satisfi satisfi less connect result suggest attend richer perspect relationship qualiti may spur addit understand mani factor associ meaning coupl relationship | D010549 | T033;T041 |
34,661,917 | system eigenmobl zone electrophoresi general move boundari approach system zone capillari zone electrophoresi repres import topic interest theoret point also import practic paper aim contribut understand system zone one fundament properti electrophoret system develop altern approach far use vector matrix model calcul system mobil system eigenmobl present model base solut differenti form move boundari equat result acid base system singl algebra equat valid univers zone compris number constitu mono polyhydr strong weak acid base andor amphoter compound valu describ solut previous model consist explicit form express system eigenmobl homogen zone given composit function known quantiti obtain equat shown common sourc various simplifi equat obtain past particular simpl system applic simplifi equat discuss term complet result number output system eigenmobl non buffer system occurr previous unreport non zero valu system eigenmobl discuss equal arithmet averag mobil solvent ion | D004573;D019075 | T121;T197;T059 |
34,661,916 | liver human mice translat strategi studi metabol disord liver metabol core whole bodi tool common use studi human liver metabol includ hepatocyt cell line primari human hepatocyt pluripot stem cell deriv hepatocyt vitro liver genet human mous model vivo howev none system mimic human liver physiolog patholog state satisfactorili liver human mice establish reconstitut mous liver human hepatocyt emerg attract anim model studi drug metabol evalu therapeut effect human liver vivo human liver great replic enzymat featur human hepatocyt applic liver human mice studi metabol disord relat less common due larg uncertain replic metabol profil compar human summar metabol characterist current applic liver human mous model metabol disord report literatur tri evalu pros con use liver human mice novel mous model studi metabol disord | D008099;D008659 | T047;T023 |
34,661,915 | valid brief version spenc children anxieti scale spanish children scas c studi aim valid self report brief version spenc children anxieti scale children scas c pre adolesc spanish children | D001007 | T048;T184;T041 |
34,661,913 | novel use franklin split len cycl hemianopia optic rehabilit hemianopia includ prescript partial apertur prismat lens fresnel lens purpos poor optic qualiti bond lens poor cosmesi made glass creat potenti hazard present altern len type reduc contrast sensit made plastic materi | D006423;D007909 | T033;T047;T073 |
34,661,912 | heat stress induc ipec j cell barrier dysfunct endoplasm reticulum stress mediat apoptosi p eifchop pathway heat stress hs induc high ambient temperatur compromis intestin epitheli cell howev under mechan hs caus intestin barrier dysfunct remain unclear studi establish vitro acut hs induc intestin damag use porcin small intestin epitheli cell ipec j expos high temperatur c h cell prolifer apoptosi tight junction tj barrier integr transcriptom profil measur result show hs decreas cell viabil increas proapoptot signal evidenc baxbcl ratio cytochrom c releas cytosol activ caspas increas p hs led decreas transepitheli electr resist increas cell permeabl downregul tj protein includ zo occludin claudin p transcriptom sequenc kegg pathway analysi reveal hs induc cell cycl arrest activ endoplasm reticulum stress er respons mediat critic transcript eif proapoptot molecul ddit known chop furthermor inhibit er phenylbutyr pba administr knockdown eif chop signific attenu ipec j cell apoptosi p transmiss electron microscopi analysi suggest pba inhibit hs induc increas er lumen diamet indic ultrastructur sign er addit hs induc impair tjs signific attenu pba p collect hs induc er activ p eifchop signal pathway impair epitheli barrier integr trigger intestin epitheli cell apoptosi | D059865;D015852 | T049;T116;T123 |
34,661,908 | fifti year articl jeq trace element environ futur outlook fifti year ago journal environment qualiti jeq launch provid outlet public research impact agricultur environ vice versa core concept jeq advanc environment scienc emphasi understand factor affect fate risk qualiti soil water atmospher system system process affect plant microb anim trace element focus area jeq present higher natur concentr may pose risk environment qualiti ecosystem health depend bioavail trace element biogeochem cycl affect anthropogen influenc land air water includ land manag practic agricultur mine journal environment qualiti publish prolif catalog scientif research public trace element risk human soil health water qualiti environ review research trace element impact environment qualiti present special focus work publish jeq | D012989;D014131 | T131;T121;T196;T123 |
34,661,907 | repair larg nasal septal perfor use upper later cartilag mucos flap describ surgic techniqu closur outcom larger septal perfor repair incorpor mucosa undersurfac upper later cartilag superior posit advanc flap | D061270 | T190 |
34,661,906 | treatment pattern outcom palliat system therapi patient salivari duct carcinoma adenocarcinoma otherwis specifi salivari duct carcinoma sdc adenocarcinoma otherwis specifi adeno nos rare salivari gland cancer data efficaci system therapi diseas limit | D000230;D044584;D012468 | T191 |
34,661,905 | menopaus workplac polici way forward backward workplac polici regard women reproduct menopaus health garner global attent peri post menopaus stage may turbul time mani women experienc debilit symptom none symptom menopaus recognis employ due various impact implement polici pertain women alien older femal worker creat prejudic surround work capabl piec identifi avenu inclus menopaus symptom pre exist polici highlight issu face menopaus women current age | D008593;D017132 | T039;T082 |
34,661,904 | greenhous experi partial support infer ecogeograph isol nich model clarkia sister speci ecogeograph isol geograph isol caus ecolog diverg thought primari import speciat yet difficult demonstr quantifi determin whether distribut limit diverg adapt histor conting gold standard reciproc transplant speci geograph rang altern ecogeograph isol infer speci distribut model nich diverg test use wide avail environment occurr data | D031663 | T002 |
34,661,903 | provis folic acid reduc arsenic toxic arsenic expos children adult arsenic common environment toxin exposur arsenic particular inorgan form contamin food drink water import public health burden worldwid associ increas risk neurotox congenit anomali cancer advers neurodevelop children arsenic excret follow methyl reaction mediat folat provis folat folic acid supplement could facilit arsenic methyl excret therebi reduc arsenic toxic | D001151 | T131;T121;T196 |
34,661,902 | compar evalu factor compon base structur equat model approach correct construct represent structur equat model sem evolv two domain factor base compon base depend whether construct statist repres common factor compon two sem domain conceptu distinct assum popul model either statist construct proxi statist sem approach use estim model whose construct represent correspond assum howev sem approach often evalu compar popul factor model provid mislead conclus relat perform part popul compon model relationship clear formul also fundament import examin robust sem approach potenti misrepresent construct research may often lack clear theori determin whether factor compon repres given construct address issu studi begin clarifi sever popul compon model relationship provid comprehens evalu four sem approach maximum likelihood approach factor score regress factor base sem well general structur compon analysi gsca partial least squar path model plspm compon base sem various experiment condit confirm factor base sem approach prefer estim factor model wherea compon base sem approach chosen compon model import compon base approach general robust construct misrepresent factor base one compon base approach gsca chosen plspm regardless whether construct misrepres | D000077272 | T062;T081 |
34,661,901 | differ glomerular filtrat rate estim formula prescrib doac oldest patient appropri dosag bleed risk post hoc analysi prospect cohort direct oral anticoagul doac pharmacokinet depend estim glomerular filtrat rate egfr whose estim crucial optim riskbenefit balanc | D051436 | T047 |
34,661,900 | gender specif associ speech frequenc hear loss high frequenc hear loss cognit impair among older communiti dweller china studi aim atinvestig relationship speech frequenc hear loss sfhl high frequenc hear loss hfhl cognit impair ci determin whether differ gender among older communiti dweller china | D060825;D006316 | T048;T047 |
34,661,899 | immun respons malaria vaccin strategi malaria pandem near half global popul risk caus parasit plasmodium speci particular p falciparum high morbid mortal especi among children urgent need develop popul protect vaccin sub saharan low incom countri p falciparum malaria endem year endeavour children adult safeti efficaci clinic trial p falciparum circumsporozoit protein antigen target specif antibodi induc recombin vaccin call trs trs author malawi govern first malaria vaccin year age children protect malaria malaria vaccin clinic trial also promis candid includ origin live x ray attenu p sporozoit vaccin induc antigen specif cell immun liver stage malaria parasit blood symptomat stage target specif antibodi parasit infect erythrocyt import pathogen placenta infect erythrocyt sequestr demograph distribut plasmodium speci pathogen infect peopl discuss role innat phagocyt cell malaria antigen specif cell immun well specif antibodi product b cell highlight paramount role cytotox cd cellular immun malaria peopl protect also includ | D017780;D016778 | T129;T047;T121 |
34,661,898 | candida pathogen interplay immun system candida speci opportunist fungal pathogen part normal skin mucos microflora overgrowth candida caus infect thrush life threaten invas candidiasi immunocompromis patient though candida albican high preval sever non albican speci also isol nosocomi infect candida sp present gut peopl crohn diseas certain type neurolog disord hyphal form biofilm virul state addit candida use sever secret cell surfac molecul ph relat antigen high affin glucos transport phosphoglycer mutas lipas establish pathogen strong innat immun respons elicit candida via dendrit cell neutrophil macrophag three complement pathway also activ product proinflammatori cytokin il il signal differenti cd cell th th cell wherea il il il induc th cell import lymphocyt reflect deplet cell count patient prone candidiasi anti candida antibodi also play role candidiasi use various mechan target virul enzym exhibit direct candidacid activ howev signific antibodi respons infect remain controversi furthermor candida strain evolv molecular strategi evad sophist host attack proteolysi compon immun system interf immun signal pathway emerg sever non albican speci resist current antifung agent make treatment difficult therefor deeper insight interact candida host immun system requir discoveri novel therapeut option | D002175;D002177 | T004;T047 |
34,661,897 | vaccin strategi mycobacterium tuberculosi bcg beyond tuberculosi tb high contagi diseas caus mycobacterium tuberculosi mtb major caus morbid mortal across globe clinic outcom tb infect suscept vari among individu even among differ popul contribut host genet factor polymorph human leukocyt antigen hla allel well cytokin gene nutrit differ popul immunometabol environment factor till bcg vaccin avail prevent tb protect render bcg pulmonari tb uniform deliv vaccin give consist protect tb great challeng rise burden drug resist tb thus expect quit high new generat vaccin improv effici bcg without show discord form tb effect individu age part world order enhanc improv efficaci bcg differ strategi implement consid immunogen various mtb virul factor well recombin strain co administr adjuv use appropri vehicl deliveri chapter discuss sever pre clinic attempt boost bcg subunit vaccin test murin model also highlight various recombin tb vaccin undergo clinic trial promis candid includ new generat live recombin bcg rbcg vaccin vpm delet one two virul gene encod mycobacteria infect macrophag inhibitor protein host macrophag apoptosi autophagi key event kill erad mtb vaccin rbcg urec hli hm r rbcg urec hli nuog former vaccin pass phase iib clinic trial involv south african infant adult thus aim elimin tb cumul effort develop better tb vaccin possibl new hope posit outcom | D009169;D032581 | T007;T121;T129 |
34,661,896 | innat immun pattern recognit receptor mycobacterium tuberculosi natur consequ pathogenesi tuberculosi innat immun mycobacterium tuberculosi critic earli respons prevent establish infect despit recent advanc understand host pathogen dialogu earli stage tuberculosi tb much yet learnt natur consequ dialogu ultim determin path infect name either earli clearanc tuberculosi establish tuberculosi infect lead activ tb diseas andor latent tb infect frontlin innat immun pattern recognit receptor prrs solubl factor eg collectin complement cell surfac factor eg toll like receptor c type lectin receptor dectin nod like receptor dc sign mincl mannos receptor mcl play central role recognis tuberculosi facilit clearanc howev doubl edg sword scenario factor also involv enhanc pathogenesi well furthermor innat immun also critic bridg establish subsequ adapt immun respons also respons granuloma format cordon tuberculosi infect establish latenc act reservoir bacteri persist dissemin futur diseas chapter discuss current understand pattern recognit tuberculosi innat immun role play pathogenesi protect tb | D009169;D014376 | T007;T047 |
34,661,895 | pathogenesi host immun respons leprosi leprosi ancient insidi diseas caus mycobacterium lepra skin peripher nerv undergo chronic granulomat infect lead sensori motor impair characterist deform suscept leprosi diseas state determin manifest innat immun resist mediat cell monocyt lineag due insuffici innat resist granulomat infect establish influenc specif cellular immun clinic present leprosi rang two stabl polar form tuberculoid lepromat three unstabl borderlin form tuberculoid form involv th respons character well demarc granuloma infiltr cd lymphocyt contain epitheloid multinucl giant cell lepromat leprosi characterist granuloma unstructur accumul ineffect macrophag contain engulf pathogen th respons characteris ifn il product activ macrophag order kill intracellular pathogen convers th respons character product il il il help antibodi product consequ downregul cell mediat immun induc th respons lepar long generat time inabl grow cultur laboratori condit make studi challeng nine band armadillo still remain best clinic immunolog model studi host pathogen interact leprosi chapter present cellular morpholog genom uniqu lepra pathogen show tropism schwann cell macrophag dendrit cell | D007918 | T047 |
34,661,894 | antibiot resist mechan transmiss acinetobact baumannii discoveri penicillin year ago subsequ uptak healthcar system around world revolutionis global health mark begin golden age antibiot discoveri new antibiot readili discov natur sourc refin therapi save million live toward end last centuri rate discoveri slow near standstil lack discoveri compound rapid emerg spread bacteri pathogen exhibit resist multipl antibiot therapi threaten sustain global healthcar system acinetobact baumannii opportunist pathogen whose preval impact grown signific last year recognis baromet antibiot resist crisi due divers array mechan becom resist | D040981 | T007 |
34,661,893 | sar cov pathogen mechan host immun respons sever acut respiratori syndrom coronavirus sar cov envelop posit sens rna coronavirus respons covid pandem sinc decemb coronavirus diseas covid affect million peopl million death global per dashboard date march virus capabl transmit human human via inhal infect respiratori droplet aerosol contact infect fomit clinic patient covid present sever respiratori distress syndrom similar present respiratori viral infect huge variat host respons exist result symptom vari mild moder comorbid cardiovascular diseas hypertens diabet coagul dysfunct stroke malign tumor multipl organ dysfunct syndrom well age sex associ sever covid case far target therapi develop treat diseas exist drug investig repurpos chapter discuss epidemiolog clinic featur covid pathogenesi innat adapt immun respons mount host sar cov infect deeper understand host pathogen interact fundament develop vaccin | D000086382;D000086402 | T047;T005;T067 |
34,661,892 | immun respons mer cov human anim middl east respiratori syndrom coronavirus mer cov emerg zoonot coronavirus circul dromedari camel sporad transmit human subsequ result communiti nosocomi case viral infect human rang diseas sever asymptomat sever pneumonia death wherea infect camel usual asymptomat approv antivir therapi vaccin mer cov infect although number therapeut vaccin candid develop human camel date limit research immun respons pathogenesi mer cov human camel chapter focus mer cov specif immun differ speci detail regard various anim model | D018352;D065207 | T047;T005 |
34,661,891 | current insight host immun respons respiratori viral infect respiratori viral infect often lead sever ill vari mild asymptomat upper respiratori tract infect sever bronchiol pneumonia orand chronic obstruct pulmonari diseas common viral infect includ limit influenza virus respiratori syncyti virus rhinovirus coronavirus often lead caus morbid mortal sinc lung continu expos foreign particl includ respiratori pathogen also well equip recognit antivir defens util complex network innat adapt immun cell immedi upon infect rang proinflammatori cytokin chemokin interferon respons generat therebi make immun respons two edg sword one hand requir elimin viral pathogen hand prolong respons lead chronic infect signific pulmonari damag sinc vaccin respiratori virus avail better understand virus host interact lead develop immun respons critic need design effect therapi limit sever inflammatori damag enhanc viral clearanc compliment current strategi target virus chapter discuss host respons common respiratori viral infect key player adapt innat immun fine balanc exist viral clearanc immun mediat damag | D017934;D012141;D014777 | T047;T005 |
34,661,890 | innat immun respons hiv innat immun system compris cellular humor player recognis erad invad pathogen therefor interplay retrovirus innat immun emerg import compon viral pathogenesi hiv infect human result hematolog abnorm immun suppress well repres chang cdcd cell ratio consequ cell death caus cd lymphopenia innat immun respons mucos barrier complement dcs macrophag nk cell well cytokinechemokin profil attain great import acut hiv infect thus prevent mucos captur transmiss hiv convers hiv evolv overcom innat immun respons rna mediat rapid mutat pathogen associ molecular pattern pamp modif regul nk cell activ complement receptor result increas secret inflammatori factor consequ epitheli tissu line femal reproduct tract express innat immun sensor includ anti microbi peptid respons form primari barrier display effect potent anti hiv activ phase iii clinic trial | D015658;D006679;D015497 | T034;T047;T005 |
34,661,889 | mechan immun evas ebola virus ebola virus epidem west africa also spread usa uk europ largest report outbreak till date world health organ https appswhointirisbitstreamhandleebolasitrepjunengpdf jsessionidbdbcddbebbaffada sequenc recent ebola outbreak democrat republ congo rais immens global concern sever often fatal infect although sporad sever lethal ebola virus diseas outbreak led extens research worldwid virus vaccin world health organ https wwwwhointennew roomdetail final trial result confirm ebola vaccin provid high protect diseas henao restrepo et al lancet drug hayden natur dyall et al j infect dis suppl develop effort ebola virus research hotspot approv therapeut current avail center diseas control prevent https wwwcdcgovvhfebolacliniciansvaccineindexhtml center diseas control prevent https wwwcdcgovvhfebolatreatmentindexhtml ebola virus evolv sever mechan host immun evas facilit replic pathogenesi chapter describ ebola virus morpholog genom entri replic pathogenesi viral protein involv host immun evas understand under molecular mechan immun evas may facilit develop addit novel sustain strategi dead virus | D029043;D058872;D019142 | T047;T005;T067 |
34,661,888 | human papillomavirus associ cancer human papillomavirus hpv causat agent major anal head neck oral oropharyng penil vagin vulvar cervic cancer cervic cancer fourth common cancer among women worldwid diagnos human malign neoplasm approxim attribut hpv includ cervic anal cancer vagin vulvar penil oropharyng cancer hpv type identifi sequenc date howev certain type hpv frequent malign lesion consid major risk factor develop cancer hpv infect transient individu immunocompet may clear infect hpv infect receiv littl attent clinician general public polici maker lack attent may underpin dead increas problem newli acquir infect potenti persist becom incur lifelong afflict addit success treatment hpv infect current exist despit great stride toward understand mechan under hpv pathogenesi moreov ampl research proven use prophylact vaccin gardasil cervarix led document progress decreas burden hpv infect howev countri introduc govern fund nation hpv vaccin program protect young men women chapter summar hpv infect detect prevent also shed light non cervic hpv relat cancer rapid increas develop countri toward cervic cancer | D052685;D001005;D030361;D002583 | T191;T047;T005 |
34,661,887 | norovirus gii astrovirus shellfish mangrov region canania brazil molecular detect character recent year annual case gastroenter report world high rate suggest associ consumpt shellfish enter virus tissu anthrop activ consid sourc environment pollut main respons contamin pathogen microorgan aquat environ object studi evalu rt semi nest pcr presenc astrovirus astv norovirus genogroup ii nov gii mussel mytella falcata oyster crassostrea brasiliana collect two site lagunar complex canania state paulo brazil total sampl mussel oyster sampl analyz astv identifi shellfish sampl nov gii detect sampl mussel sampl oyster sampl posit sampl analyz nucleotid sequenc molecular character reveal brazilian sampl group clade along sequenc brazil japan mexico amino acid sequenc similar among sampl studi compar strain isol clinic case brazil screen shellfish presenc health signific enter virus help prevent outbreak among consum contribut improv estuarin environ | D005759;D029322;D010125 | T204;T047;T005 |
34,661,886 | biodivers success lactic microbiota involv brazilian buffalo mozzarella chees product biodivers success lactic acid bacteria lab involv product storag brazilian buffalo mozzarella chees evalu isol character gram stain catalas test abil grow differ condit temperatur ph concentr nacl product co glucos biodivers success lab isol chees product evalu rrna gene sequenc random amplifi polymorph dna rapd pcr restrict fragment length polymorph rflp pcr techniqu strain grow well c toler nacl general best ph grow leuconostoc mesenteroid lacticaseibacillus casei limosilactobacillus fermentum enterococcus sp preval present almost step product lab strain typic found tradit italian chees except leuconostoc citreum speci sixti cluster obtain rapd pcr similar isol lab cluster similar rflp pcr techniqu appli techniqu enabl valuabl elucid lab biodivers success contribut better understand specif microbi cultur technolog aptitud chees | D002611;D064307 | T028;T001;T032;T168 |
34,661,884 | molecular therapi choroideremia pre clinic clinic progress date choroideremia inherit retin diseas characteris degener light sens photoreceptor support retin pigment epithelium under choroid patient present symptom classic rod cone dystrophi night blind earli life progress peripher visual field loss central vision declin slow progress legal blind choroideremia monogen caus mutat chm eight clinic trial three phase four phase one phase start four alreadi finish evalu therapeut efficaci gene supplement mediat subretin deliveri adeno associ virus serotyp aav vector express chm furthermor one phase clinic trial initi evalu effici novel aav variant deliv chm outer retina follow intravitr deliveri last non viral mediat chm replac strategi current develop could lead futur clinic trial summaris rational behind various studi well result publish date divers trial current place choroideremia forefront retin gene therapi field consequ trial outcom regardless result potenti chang landscap gene supplement inherit retin diseas | D015794 | T047 |
34,661,883 | associ advers childhood experi ace obes underweight children aim studi test hypothesi advers childhood experi ace relat obes underweight childhood associ ace weight abnorm modul type ace sex socioeconom status ses indic | D000076783 | T033 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.