PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,686,046 | accur predict mutat induc frequenc shift chlorophyl protein simpl electrostat model photosynthet pigment protein complex control local chlorophyl chl transit frequenc varieti electrostat steric forc site direct mutat modifi local spectroscop tune provid critic insight nativ photosynthet function offer tantal prospect creat ration design chl protein custom optic properti unfortun present proven method exist reliabl predict mutat induc frequenc shift advanc limit method util quantit applic address challeng construct seri point mutant water solubl chlorophyl protein lepidium virginicum use test reliabl simpl comput protocol mutat induc site energi shift protocol use molecular dynam prepar mutant protein structur charg densiti coupl model adolph et al photosynth res site energi predict graphic interfac implement protocol automat publish onlin http nanohuborgtoolspigmenthunt except singl outlier presum due unexpect structur chang find calcul frequenc shift match experi remark well averag error nm nm spread wavelength anticip accuraci method improv futur advanc sampl mutant protein structur | D009154;D055672 | T070;T045 |
34,686,044 | structur benzothiadiazin zwitterion phospholipid cell membran use drug deriv benzothiadiazin bicycl heterocycl benzen deriv becom widespread treatment diseas hypertens treat diuret bendroflumethiazid chlorothiazid low blood sugar treat non diuret diazoxid human immunodefici virus among other work investig interact benzothiadiazin basic compon cell membran solvent phospholipid cholesterol ion water analysi mutual microscop interact central import elucid local structur benzothiadiazin well mechan respons access benzothiadiazin interior cell perform molecular dynam simul benzothiadiazin embed three differ model zwitterion bilay membran made dimyristoylphosphatidylcholin dioleoylphosphatidylcholin dioleoyl sn glycero phosphoserin cholesterol insid aqueous sodium chlorid solut order systemat examin microscop interact benzothiadiazin cell membran liquid crystallin phase condit data obtain radial distribut function hydrogen bond length potenti mean forc base revers work calcul observ benzothiadiazin strong affin stay cell membran interfac although fulli solvat water short period time furthermor benzothiadiazin abl bind lipid cholesterol chain mean singl doubl hydrogen bond differ characterist length | D002784;D010743 | T121;T109;T123 |
34,685,782 | spontan calcium oscil differenti calcium imag analysi rat cochlear nucleus neural stem cell causal therapi auditori pathway inner ear diseas still yet avail clinic applic regen medicin approach discuss examin possibl therapi option neural stem cell could play role regener auditori pathway recent year neural stem progenitor cell identifi cochlear nucleus second nucleus auditori pathway current investig aim analyz cell matur concern cellular calcium activ cochlear nuclei pnd cd rat microscop dissect propag neurospher free float cultur stem cell medium neurobas b glutamax egf bfgf day dissoci plate cell took place withdraw growth factor addit retino acid induc neural cell differenti calcium imag analysi bapta oregon green carri differ time differenti phase addit influenc differ voltag depend calcium channel analyz target applic inhibitor l n r type calcium channel purpos compar examin perform cn nscs primari cn neuron cell differenti signific increas spontan neuron calcium activ demonstr differenti stage specif frequenc spontan calcium oscil measur differ region individu cell initi highest frequenc spontan calcium oscil ascertain matur somata time overtaken calcium oscil axon dendrit addit area growth cone increas activ determin inhibit voltag depend calcium channel express function differenti process confirm compar pattern matur channel found cn nscs primari cn neuron present result show neural stem cell rat cochlear nucleus differenti morpholog also function spontan calcium activ great relev term neurogenesi integr exist neuron structur function aspect neurogenesi within auditori pathway could serv futur target exogen control neuron regener | D020013;D002454;D007091 | T043;T066 |
34,685,781 | pancreat cell glcnac transferas overexpress increas suscept metabol stressor femal mice nutrient sensor glcnac transferas ogt sole enzym add glcnac modif onto protein play critic role pancreat cell surviv insulin secret hypothes cell ogt overexpress would confer protect cell failur respons metabol stressor high fat diet hfd streptozocin stz generat cell specif ogt overexpress ogto mice signific increas ogt protein level glcnac modif protein observ islet normal chow diet uncov ogto mice show normal peripher insulin sensit glucos toler regular chow diet howev challeng hfd femal ogto homozyg hz mice develop mild glucos intoler despit increas insulin secret normal cell mass femal mice normal resist low dose stz treatment ogto hz mice develop hyperglycemia glucos intoler post stz treatment transcriptom analysi islet loss gain ogt rna sequenc show common alter pathway involv pro surviv erk akt inflammatori regul il nfk togeth data show possibl gene dosag effect ogt import glcnac cycl cell surviv function regul glucos homeostasi | D013312 | T121;T039;T046;T032;T040 |
34,685,779 | ethylen induc sound stimul enhanc anthocyanin accumul grape berri skin direct upregul udp glucos flavonoid glucosyltransferas global warm result loss anthocyanin accumul berri skin sound stimul use potenti method enhanc fruit color develop sinc mani plant recogn sound vibrat extern stimulus alter physiolog status respons sound stimul sine wave sound hz enhanc anthocyanin accumul grape cultur cell berri skin field grown grapevin earli stage ripen transcript ufgt aco encod key enzym anthocyanin ethylen biosynthesi respect upregul grape cultur cell expos sound stimul contrast transcript myba nced encod transcript factor ufgt key enzym abscis acid biosynthesi respect affect sound stimul treatment ethylen biosynthesi inhibitor aminoethoxyvinyl glycin hydrochlorid rever enhanc anthocyanin accumul sound stimul promot assay use gus report gene demonstr ufgt promot direct activ ethylen releas compound ethephon enhanc anthocyanin accumul grape cultur cell conclud sound stimul enhanc anthocyanin accumul direct upregul ufgt ethylen biosynthesi find suggest sound stimul contribut allevi poor color berri skin novel innov practic techniqu viticultur | D013016;D015854 | T044;T070 |
34,685,778 | plasma biomark profil heart failur patient preserv eject fraction spironolacton treatment result aldo dhf trial pathophysiolog heart failur preserv eject fraction hfpef poor understood therapeut strategi lack studi aim identifi plasma protein pathophysiolog relev hfpef respect spironolacton induc effect assess biomark plasma sampl hfpef patient belong aldo dhf trial baselin bl one year treatment follow fu spironolacton verum placebo bl various biomark show signific associ two aldo dhf primari end point paramet ee peak vo ten protein includ adrenomedullin fgf inflammatori peptid eg tnfrsfa trailr signific associ paramet suggest role clinic hfpef present protein express chang bl fu signific differ verum placebo among renin growth hormon adrenomedullin inflammatori protein eg tnfrsfa il ilra indic distinct spironolacton mediat effect bl level five protein eg inflammatori marker ccl ilra ilra show signific differ effect instantan risk hospit verum placebo studi identifi plasma protein differ implic hfpef follow spironolacton treatment futur studi need defin precis mechanist involv | D013318 | T033;T034;T201 |
34,685,777 | relationship plasma proteom chang inflammatori marker bariatr surgeri sever obes diseas associ multipl advers effect health metabol bariatr surgeri mbs signific effect multipl bodi system shown improv inflammatori marker previous short term follow studi evalu associ chang inflammatori marker crp il tnf circul protein mbs | D050110 | T061 |
34,685,776 | metagenom profil fecal deriv bacteri membran vesicl crohn diseas patient past mani studi suggest crucial role dysbiosi gut microbiota etiolog crohn diseas cd howev despit import player host bacteria interact role bacteri membran vesicl mv larg overlook pathogenesi cd studi address composit bacteri mv composit fecal sampl cd patient compar composit healthi individu | D056186 | T091 |
34,685,774 | neuron radial glial cell communic via bmpid signal key long term mainten regen capac adult zebrafish telencephalon central nervous system adult zebrafish display extraordinari neurogen regen capac zebrafish adult brain regen capac reli neural stem cell nscs care manag nsc pool howev mechan control nsc pool mainten yet fulli understood recent bone morphogenet protein bmps downstream effector id inhibitor differenti suggest act key player nsc mainten constitut regen condit investig role bmpid signal process use differ genet pharmacolog approach data show bmps main express neuron adult telencephalon id express nscs suggest neuron nsc communic via bmpid signal axi furthermor manipul bmp signal condit induc repress bmp signal via heat shock lead increas decreas id express nscs respect induct id follow increas number quiescent nscs knock id express caus increas nsc prolifer agreement genet ablat id function lead increas prolifer nscs follow deplet stem cell pool concomit failur heal injuri repeat injur mutant telencephala moreov pharmacolog inhibit bmp notch signal suggest two signal system cooper converg onto transcript regul interest brain injuri lead deplet nscs anim lack bmpid signal despit intact notch pathway taken togeth data demonstr neuron feedback nsc prolifer bmpid signal act safeguard nsc pool regen condit | D002450 | T043 |
34,685,766 | respiratori syncyti virus matrix protein chromatin associ key transcript inhibit infect cell morbid mortal caus global preval human respiratori pathogen respiratori syncyti virus rsv approach world wide influenza previous demonstr rsv matrix protein shuttl signal depend fashion host cell nucleus cytoplasm traffick central rsv replic assembl analyz detail nuclear role first time use rang novel approach includ quantit analysi de novo cell transcript situ presenc absenc rsv infect ectop express well situ dna bind show depend amino acid inhibit host cell transcript rsv infect cell well cell transfect express clear correl nuclear level degre transcript inhibit analysi bacteri express protein deriv thereof mutat key residu within rna bind domain indic bind dna well rna cell free system parallel result point mutat deriv implic arginin lysin contrast basic residu lysin critic import residu inhibit transcript dna bind situ vitro import recombin rsv carri arginin lysin mutat show attenu infect cultur cell anim model concomit alter inflammatori respons find defin rsv chromatin interfac critic host transcript inhibit infect import implic anti rsv therapeut develop | D014158 | T045 |
34,685,764 | neurogen potenti kda mitochondri transloc protein tspo pluripot p stem cell kda transloc protein tspo key mitochondri target differ tspo ligand exert neuroprotect effect assay neurogen potenti tspo induc neuron differenti pluripot p stem cell vitro studi chang cell morpholog cell prolifer cell death cell cycl mitochondri function level pluripot neurogenesi p stem cell treat tspo ligand pk comparison differenti induc retinoid acid ra undifferenti p stem cell observ pk abl activ differenti p stem cell promot develop embryoid bodi pk also induc chang cell cycl decreas cell prolifer activ cell death mitochondri metabol also enhanc pk thus increas level reactiv oxygen speci ca atp well mitochondri membran potenti marker pluripot neurogenesi also alter cell differenti process pk induc differenti p stem cell high predisposit toward neuron linag compar cell differenti induc ra thus suggest relev neurogen potenti tspo along broad therapeut implic | D055495 | T040 |
34,685,762 | microenviron role mycosi fungoid szari syndrom progress therapeut implic mycosi fungoid mf sezari syndrom ss common cutan cell lymphoma hypothes interact immun system cutan cell neoplast element may play role mfss pathogenesi progress | D018450;D059016 | T033;T070;T046 |
34,685,759 | foxdl negat regul chordin transcript neuroectoderm xenopus gastrula inhibit bone morphogenet protein bmps primari step toward neuroectoderm format vertebr process spemann organ dorsal mesoderm play decis role secret sever extracellular bmp inhibitor chordin chrd chrd physic interact bmp protein inhibit bmp signal trigger express neural specif transcript factor tfs includ foxdl thus chrd induc bmp inhibit manner promot neuroectoderm format howev regulatori feedback mechan foxdl mesoderm gene express germ layer specif fulli elucid studi investig regulatori mechan foxdl chrd mesoderm gene demonstr foxdl inhibit chrd express neuroectoderm format two way first foxdl direct bind fre foxdl respons element within chrd promot region inhibit transcript second foxdl physic interact smad smad interact block smad smad bind activin respons element are within chrd promot site direct mutagenesi fre within chrd promot complet abolish repressor activ foxdl rt pcr report gene assay result indic foxdl strong inhibit mesoderm ectoderm specif marker gene maintain neural fate altogeth result suggest foxdl negat regul chrd transcript dual mechan thus studi demonstr exist precis reciproc regul chrd transcript neuroectoderm mesoderm germ layer specif xenopus embryo | D018507;D014158 | T045 |
34,685,755 | mitochondri phospholipid homeostasi regul aaa proteas paiap affect organism age mitochondria ubiquit organell eukaryot organ number essenti function includ synthesi iron sulfur cluster amino acid lipid adenosin triphosph atp age fungal age model podospora anserina inner mitochondri membran imm undergo promin morpholog alter ultim result function impair sinc phospholipid pls key compon biolog membran mainten membran plastic integr via regul pl biosynthesi indispens report result lipidom analysi isol mitochondria p anserina reveal age relat reorgan mitochondri pl profil involv aaa proteas paiap proteolyt regul pl metabol absenc paiap enhanc biosynthesi characterist mitochondri pls lead signific alter acyl composit mitochondri signatur pl cardiolipin cl induc mitophagi alter presum caus lifespan increas paiap delet mutant standard growth condit howev paiap requir elev temperatur degrad superflu cl synthas pacrd glycolyt growth overal studi uncov promin role paiap regul pl homeostasi order adapt membran plastic fluctuat environment condit occur natur | D006706 | T038 |
34,685,753 | chemic genet screen drosophila germlin uncov small molecul drug sensit stem cell insult induc apoptosi cancer stem cell contrast differenti daughter cell endur genotox insult escap apoptosi caus tumor recurr understand normal adult stem cell surviv go quiescenc may help identifi druggabl pathway cancer stem cell co opt studi util genet tractabl model stem cell surviv drosophila gonad screen drug candid probe chemic genet interact studi employ three level small molecul screen medium throughput primari screen male germlin stem cell gscs secondari screen irradi protein constrain food femal gscs tertiari screen breast cancer organoid vitro herein uncov seri small molecul drug candid may sensit cancer stem cell apoptosi assess small molecul chemic genet interact germlin identifi nf b pathway essenti druggabl pathway gsc quiescenc viabil studi demonstr power drosophila stem cell nich model system target drug discoveri | D005820 | T059;T060 |
34,685,752 | structur equat model sem analysi sequenc variat green plant regener via anther cultur barley process anther cultur involv numer abiot stress requir cellular reprogram microspor development switch plant regener stress affect dna methyl pattern sequenc variat number green plant regener recent barley hordeum vulgar l mediat analysi link dna methyl chang copper cu silver ag ion concentr sequenc variat glucan green plant durat anther cultur time although sever model use explain particular aspect relationship factor general complex model employ type data establish studi combin previous describ partial model singl complex model use structur equat model approach base evalu model demonstr stress condit starvat dark influenc glucan employ cell glycolysi tricarboxyl acid cycl addit cu ag ion affect dna methyl induc sequenc variat moreov ion link dna methyl green plant structur equat model also show role time relationship paramet includ model influenc plant regener via anther cultur util structur equat model may scientif practic implic demonstr link biolog phenomena eg cultur induc variat green plant regener biochem pathway provid opportun regul phenomena particular biotechnolog purpos | D014644;D008954;D046509 | T070;T059;T075 |
34,685,751 | involv autophagi age chronic cholestat diseas autophagi housekeep lysosom degrad process involv numer physiolog patholog process eukaryot cell dysregul hepat autophagi describ sever condit obes diabet cholestat diseas review role autophagi focus age relat cholestat diseas discuss therapeut potenti molecular target identifi date accumul toxic bas main caus cell damag cholestasi patient bas receptor fxr implic regul hepat autophagi mechan cholestasi induc liver damag includ mitochondri dysfunct oxid stress er stress lead cell death ultim liver fibrosi compensatori mechan reduc damag stimul autophagi seem amelior liver damag autophag activ decreas age sever speci wherea basic extend lifespan anim suggest one converg mechan sever longev pathway strategi aim induc autophagi yet test cholestasi patient howev stimul view novel therapeut strategi may reduc age depend liver deterior also mitig hepat steatosi | D001343 | T043 |
34,685,750 | effect fibrot cell type densiti atrial fibril dynam silico studi remodel atrial fibril af underlin electr structur chang atria fibrosi hallmark arrhythmogen structur alter fibrosi import featur af substrat lead abnorm conduct consequ mechan dysfunct fibrot process compris presenc fibrot cell includ fibroblast myofibroblast fibrocyt play import role fibrillatori dynam work assess effect diffus fibrosi densiti intermingl presenc three type fibrot cell dynam persist af purpos three fibrot cell electr coupl cardiomyocyt realist model human atria low high fibrosi densiti implement left atrium accord diffus fibrosi represent analyz action potenti durat conduct veloc fibrillatori conduct pattern addit frequenc analysi perform virtual electrogram test fibrosi configur generat signific conduct veloc reduct larger effect observ high fibrosi densiti reduct fibrocyt configur increas fibrosi densiti intensifi vulner multipl entri zigzag propag chaotic activ fibrillatori conduct complex propag pattern observ high fibrosi densiti fibrocyt cell largest proarrhythm effect left right domin frequenc gradient observ fibrosi configur fibrocyt configur high densiti generat signific gradient hz result suggest import role differ fibrot cell type densiti diffus fibrosi chaotic propag pattern persist af | D003198 | T066 |
34,685,748 | function proteom profil tripl negat breast cancer tripl negat breast cancer tnbc subtyp breast cancer compris various diseas entiti share set common featur lack express estrogen receptor progesteron receptor human epiderm growth factor receptor respect receptor status convent chemotherapi remain main therapeut option tnbc patient employ revers phase protein array approach rppa complement immunohistochemistri quantit profil activ state action key signal intermedi phosphoprotein set tnbc sampl perform supervis unsupervis approach proteom data analysi identifi group sampl share common characterist could amen exist therapi found heterogen activ multipl pathway pi kaktmtor signal common event specif individu therapeut possibl includ express oncogen kit associ cytokeratin erk posit tumor may clinic valu | D040901 | T091 |
34,685,747 | electr ventricular remodel dilat cardiomyopathi ventricular arrhythmia contribut signific morbid mortal patient heart failur hf pathomechan under arrhythmogen patient structur heart diseas impair cardiac function includ myocardi fibrosi remodel ion channel affect electrophysiolog properti ventricular cardiomyocyt dysregul ion channel express associ cardiomyopathi develop arrhythmia howev under molecular signal pathway increas recogn review summar clinic cellular electrophysiolog characterist observ dilat cardiomyopathi dcm ionic structur alter ventricular level furthermor potenti translat strategi therapeut option highlight | D055724;D020257 | T040;T042 |
34,685,745 | sildenafil mediat neuroprotect adult neonat brain injuri evid mechan futur translat cerebr stroke traumat brain injuri hypox ischem encephalopathi among frequent occur brain injuri complex pathogenesi character synergist interact alter cerebrovascular system cell death inflamm basi brain damag lead behavior neurodevelopment disabl affect subject sildenafil select inhibitor enzym phosphodiesteras pde abl cross blood brain barrier preclin data suggest sildenafil may good candid prevent repair brain injuri adult neonat aim review summar evid support neuroprotect action sildenafil discuss possibl benefit associ sildenafil current therapeut strategi | D000066829;D057170 | T043;T062 |
34,685,742 | integr analysi identifi gene associ stem immun infiltr glioblastoma imper identifi mechan confer stem cancer cell effect target moreov mani studi link stem characterist immun respons tumour therefor current studi involv gbm start studi birc one rare gene differenti express normal cancer cell cxcr gene involv surviv prolifer cscs togeth gene systemat explor use set promot methyl region gbm analysi show four gene correspond region name eom bdnf hla pecam involv birc cxcr interest found eom signific involv stem immunolog posit correl cxcr addit bdnf signific methyl negat correl birc | D052138 | T028 |
34,685,738 | evalu intern societi cutan lymphoma algorithm diagnosi earli mycosi fungoid intern societi cutan lymphoma iscl propos diagnost algorithm earli mycosi fungoid mf includ clinic histolog immunophenotyp molecular criteria analyz immunolog marker featur cell clonal earli mf case non mf case valid iscl algorithm found cd cd express differ signific earli mf non mf case epiderm discord cd express frequent identifi earli mf notabl increas cut valu cd express improv sensit furthermor tcr chain rearrang frequent detect earli mf non mf case base find propos cd cd defici mandatori immunopatholog criteria pcr base test tcr chain requir molecularbiolog criteria improv effici earli mf diagnosi use iscl algorithm | D000465;D038622;D012955 | T064;T170;T094;T067;T078 |
34,685,737 | novel balanc mechan particip stem cell therapi allevi neuropatholog cognit impair anim model alzheim diseas stem cell therapi improv memori loss cognit deficit anim model alzheim diseas under mechan remain determin may involv interact stem cell hippocamp cell transplant stem cell alter patholog state establish novel balanc base multipl signal pathway new balanc mechan regul various autocrin paracrin cytokin includ signal molecul target cell growth death stem cell treatment stimul neurogenesi inhibit apoptosi regul crosstalk apoptosi autophagi b tau patholog aberr plaqu neurofibrillari tau tangl mitig subsequ stem cell intervent c inflamm neuroinflamm lesion reliev may relat microgli mm polar immunoregul transplant stem cell modul immun cell shape pathophysiolog role immun relat gene trem cr cd e synaptogenesi function reconstruct synapt connect promot stem cell therapi multi level signal autophagi microgli activ remyelin regul new balanc mechan provid perspect challeng treatment alzheim diseas | D033581 | T061 |
34,685,735 | quantifi renin angiotensin system alter covid renin angiotensin system ras play pivot role wide seri physiolog process among inflamm blood pressur regul one key compon angiotensin convert enzym identifi entri point sar cov virus host cell therefor lot research devot studi ras dysregul covid discuss alter regulatori ras axe due sar cov infect basi seri recent clinic investig experiment analyz quantifi eg level activ ras compon perform comprehens meta analysi data view disentangl link impair ras function pathophysiolog characterist covid also review effect sever ras target drug could potenti help restor normal ras function minim covid sever final discuss conflict evid found literatur open question ras dysregul sar cov infect whose resolut would improv understand covid | D012084 | T022 |
34,685,734 | autophagi lysosom system cancer autophagi lysosom system togeth refer autophagolysosom system cellular qualiti control network maintain cellular health homeostasi remov cellular wast includ protein aggreg damag organell invad pathogen autophagolysosom system role varieti pathophysiolog disord includ cancer neurolog disord immun inflamm relat diseas metabol alter among other autophagolysosom system control tfeb master transcript regul drive express multipl gene includ autophagoli sosom compon import reactiv oxygen speci ros product control key aspect physiopatholog role autophagolysosom system may hold key synergist therapeut intervent studi review current knowledg biolog physiopatholog autophagolysosom system potenti therapeut intervent cancer | D001343 | T043 |
34,685,732 | restor cell cycl prolifer compet termin differenti skelet muscl myotub termin differenti ill defin insuffici character nonprolifer state although classic deem irrevers clear least sever termin differenti td cell type brought back cell cycl strive uncov molecular base termin differenti whose fundament understand goal addit field sought acquir abil make td cell prolifer attain end would probe molecular mechan tri understand equal import would invalu regen medicin tissu depend td cell devoid signific self repair capabl skelet muscl long use model system investig molecular foundat termin differenti summar year studi field | D002453;D002454 | T043 |
34,685,730 | origin isoform specif function exchang protein direct activ camp phylogenet analysi exchang protein direct activ camp epac epac one sever famili cellular effector prototyp second messeng camp understand origin molecular evolut epac protein perform comprehens phylogenet analysi epac epac studi demonstr unlik cousin pka epac protein present multicellular metazoa within epac famili epac associ chordat epac span entir anim kingdom despit much contemporari origin epac protein show much sequenc divers among speci suggest epac undergon select evolv faster epac phylogenet analys individu camp bind domain cbd guanin nucleotid exchang gef domain epac two conserv region two isoform reveal epac epac close cluster togeth within larger cyclic nucleotid receptor rapgef famili result support notion epac epac share common ancestor result fusion cbd pka gef rapgef hand two termin extrem ras associ ra domain show sequenc divers two isoform sequenc divers within region contribut signific isoform specif function epac import uniqu isoform specif sequenc motif within ra domain identifi | D010802 | T062;T078 |
34,685,728 | kynaahr signal suppress neural stem cell plastic neurogenesi adult zebrafish model alzheim diseas neurogenesi decreas alzheim diseas ad patient suggest restor normal neurogen respons could diseas modifi intervent studi mechan patholog induc neuro regener vertebr brain zebrafish excel model due extens neural regener capac report kynuren acid kyna metabolit amino acid tryptophan negat regul neural stem cell nsc plastic adult zebrafish brain receptor aryl hydrocarbon receptor ahr product kyna suppress amyloid toxic reduct level kynurenin amino transferas kat key enzym produc kyna nsc prolifer enhanc antagonist ahr reduc ahr agonist kyna subset ahr express zebrafish nscs express regulatori receptor ilr ngfra indic ahr posit nscs constitut new subset neural progenitor respons amyloid toxic perform transcriptom wide associ studi twas three late onset alzheim diseas load brain autopsi cohort also found sever gene compon kyna metabol ahr signal differenti express load suggest strong link kynaahr signal axi neurogenesi load | D055495;D009473 | T040;T042;T043 |
34,685,727 | modul inher nich multicellular msc spheroid reconfigur metabol enhanc therapeut potenti multicellular spheroid show three dimension organ extens cell cell cell extracellular matrix interact owe nativ tissu mimick characterist mesenchym stem cell msc spheroid consid promis implant therapeut stem cell therapi herein aim enhanc therapeut potenti tune cultiv paramet thus inher nich msc spheroid signific increas express multipl pro regen paracrin signal molecul immunomodulatori factor mscs observ optim condit spheroid cultur moreov alter cellular behavior may associ hypox nich develop spheroid core also metabol reconfigur mscs present studi provid effici method manipul therapeut capac msc spheroid thus lay solid foundat futur develop clinic applic spheroid base msc therapi regen medicin | D056747;D045164;D055153 | T022;T061 |
34,685,726 | direct differenti human pluripot stem cell toward skelet myogen progenitor purif use surfac marker advanc reprogram somat cell induc pluripot stem cell ipsc provid strong framework vitro diseas model gene correct stem cell base regen medicin case skelet muscl disord ipsc use generat skelet muscl progenitor studi diseas mechan implement treatment muscl disord recent develop improv direct differenti method deriv skelet myogen progenitor hipsc method allow short term week effici skelet myogen induct cell human pluripot stem cell escsipsc use small molecul induc mesoderm subsequ myotom progenitor without need gene integr modif initi differenti skelet myogen progenitor purifi unwant cell use surfac marker cd cd myogen progenitor extens character use vitro gene expressiondifferenti profil well vivo engraft studi dystroph mdx muscl injuri vml rodent model proven abl engraft form matur myofib well seed muscl stem cell current protocol describ detail step step guid method outlin import experiment detail troubleshoot point applic human pluripot stem cell | D002454;D024510 | T043;T042 |
34,685,725 | model hypox stress vitro use human embryon stem cell deriv cardiomyocyt matur fgf ascorb acid treatment matur cardiomyocyt cms obtain human pluripot stem cell hpscs requir accur vitro model adult onset cardiac diseas drug discoveri found fgf ascorb acid aa induc differenti bg human embryon stem cell cardiogen mesoderm cell hesc cmcs matur ventricular cms co treatment bg hesc cmcs fgfaa synergist induc differenti matur ventricular cms fgfaa treat bg hesc cms robust releas acut myocardi infarct ami biomark ctni ck mb myoglobin cultur medium respons hypox injuri hypoxia respons gene potenti cardiac biomark prove diagnosi prognosi coronari arteri diseas induc fgfaa treat bg hesc cms respons hypoxia base transcriptom analys studi demonstr feasibl model hypox stress vitro use hesc cms matur solubl factor | D002454;D008954;D013312 | T121;T043;T039;T046;T032;T075;T040 |
34,685,724 | bcep web server predict linear b cell epitop enhanc immunogen cross reactiv predict linear b cell epitop interest product antigen specif antibodi design peptid base vaccin present bcep web server predict linear b cell epitop tailor select epitop immunogen capabl induc cross reactiv antibodi nativ antigen bcep implement various machin learn model train dataset includ linear conform b cell epitop mine antibodi antigen protein structur best perform model base support vector machin reach accuraci independ dataset consist b cell epitop retriev immun epitop databas iedb model achiev accuraci bcep predict epitop rank accord properti flexibl access hydrophil regard immunogen judg predict present mhc ii molecul bcep also detect predict epitop locat ectodomain membran protein possess n glycosyl site hinder antibodi recognit final exemplifi use bcep sar cov spike protein show identifi b cell epitop target neutral antibodi | D016208;D000086402 | T170;T005 |
34,685,723 | unzip secret amyloid disassembl human disaggregas neurodegen diseas nds increas posit lead caus global death acceler age popul strong relationship neurodegener forecast patholog huge global health problem upcom year scenario urgent need understand basic molecular mechan associ diseas major molecular hallmark nds accumul insolubl toxic protein aggreg known amyloid extracellular intracellular deposit review current knowledg molecular chaperon specif ternari protein complex refer human disaggregas deal amyloid machineri compos constitut hsp hsc class b j protein dnajb nucleotid exchang factor apg hsp disassembl amyloid synuclein implic parkinson diseas well diseas associ protein tau huntingtin highlight recent studi led dissect mechan use chaperon system perform disaggregas activ also discuss whether chaperon mediat disassembl mechan could use solubil amyloidogen substrat final evalu implic chaperon system amyloid clearanc associ toxic could critic develop new therapi | D066329 | T116 |
34,685,722 | comparison differenti pattern wntshh signal pluripot stem cell cultur differ condit pluripot stem cell pscs character abil self renew well undergo multidirect differenti cultur condit pivot influenc differenti pattern current studi compar fate mous pscs use two cultur media chemic defin free anim reagent standard one reli serum supplement moreov assess influenc select regul wnts shh psc differenti show differenti pattern pscs cultur system differ signific cell cultur chemic defin medium preferenti underw ectoderm convers endo mesoderm differenti limit contrari cell cultur serum supplement medium effici ectoderm differenti pscs cultur chemic defin medium correl higher activ shh pathway endoderm mesoderm convers cell cultur serum supplement medium higher activ wntjnk pathway howev inhibit either canon noncanon wnt pathway result limit endo mesoderm convers pscs addit block wnt secret led inhibit psc mesoderm differenti confirm pivot role wnt signal process contrast shh turn induc psc ectoderm mesoderm differenti | D002454;D060449 | T043;T044 |
34,685,721 | regulatori activ noncod rnas ilc innat lymphoid cell ilc innat lymphocyt play essenti function protect microbi infect particip homeostat patholog context includ tissu remodel cancer inflammatori disord number lineag defin transcript factor concur establish transcript network determin ident activ distinct ilc subset howev contribut regulatori molecul control ilc develop function also recent emerg regard noncod rnas ncrnas repres key element complex regulatori network ilc biolog host protect ncrnas most lack protein code potenti endow relev regulatori activ immun nonimmun cell abil control chromatin structur rna stabil andor protein synthesi herein summar recent studi describ distinct type ncrnas main microrna long ncrnas circular rnas act context ilc biolog particular comment ncrnas exert key effect ilc control gene express cell state specif manner tune distinct function output ilc | D005786 | T045 |
34,685,718 | sirtuin interest player cours hiv infect comorbid sirtuin sirt famili enzym group nad depend deacetylas reaction split acetyl group various transcript factor histon regul mani process organ activ sirtuin link metabol control oxid stress inflamm apoptosi also affect cours viral infect reason may particip pathogenesi develop mani diseas littl known role cours human immunodefici virus hiv infect subject review cours hiv infect comorbid neurodegen disord obes insulin resist diabet lipid disord cardiovascular diseas renal bone diseas develop frequent faster compar general popul role sirtuin develop accompani diseas cours hiv infect may also interest still lack detail inform subject role sirtuin especi sirt sirt sirt indic great import cours hiv infect develop abovement comorbid | D015897 | T033 |
34,685,715 | protein compon neutrophil extracellular trap arrest cell wall protein candida albican fungal infect use host invas one defens mechan human immun system counteract infect opportunist fungal pathogen candida albican recruit neutrophil site invas subsequ product neutrophil extracellular trap net effici captur kill invad cell current studi demonstr within structur compos chromatin protein latter play pivot role entrap fungal pathogen protein compon net granular enzym elastas myeloperoxidas lactotransferrin well histon cathelicidin deriv peptid involv contact surfac c albican cell fungal partner interact typic adhesin agglutinin like sequenc protein famili al sever atyp surfac expos protein cytoplasm origin includ enolas triosephosph isomeras phosphoglycer mutas import adhes elastas mixtur protein origin net c albican cell surfac consider increas pathogen potenc human epitheli cell destruct compar fungal cell without human protein attach implement adsorb net deriv protein invad c albican cell might alter effect fungal pathogen entrap affect host colon | D054884 | T040 |
34,685,714 | sirna nanoparticl target pd l activ tumor immun abrog pancreat cancer growth human preclin model pancreat cancer character late detect frequent drug resist high metastat natur lead poor prognosi antibodi base immunotherapi show limit success pancreat cancer part owe low deliveri rate drug tumor herein describ poli lactic co glycol acid plga base sirna nanoparticl target pd l sipd l plga sipd l plga exhibit effici knockdown pd l cancer cell without affect cell viabil mgml pdac cell uptak nanoparticl success block ifn gamma mediat pd l induct consist sipd l plga sensit cancer cell antigen specif immun cell exemplifi ovalbumin target cell evalu efficaci vivo adopt pancreat pdx model human mice generat graft cd hematopoeit stem cell onto nsg mice sipd l plga signific suppress pancreat tumor growth model upregul ifn gamma posit cd cell lead apoptot tumor cell multiplex immunofluoresc analysi exhibit compar immun cell composit control sipd l plga treat tumor howev found higher granzym b express sipd l plga treat tumor suggest higher activ nk cytotox cell base result propos applic sipd l plga immunotherapeut agent pancreat cancer | D007109 | T042 |
34,685,712 | activ mtorc free fatti acid suppress lamp autophagi function via er stress alcohol relat liver diseas alcohol relat liver diseas ald character accumul hepat free fatti acid ffas liver injuri present studi aim investig mechanist target rapamycin complex mtorc play role ffa induc organell dysfunct therebi contribut develop ald cell studi conduct defin causal role under mechan ffa activ mtorc signal hepatocellular cell injuri cblj wild type mice subject chronic alcohol feed without rapamycin inhibit mtorc activ reveal palmit acid pa induc er stress suppress lamp autophagi flux mtorc depend rapamycin revers deleteri effect cebp homolog protein chop downstream atf partial modul lamp supplement rapamycin alcohol fed mice attenu mtorc activ er stress restor lamp protein improv autophagi lead amelior alcohol induc liver injuri induct mtorc signal chop also detect liver patient sever alcohol hepat studi demonstr hepat ffas play crucial role pathogenesi ald activ mtorc signal therebi induc er stress suppress lamp autophagi flux pathway repres import mechan ffa induc hepatocellular injuri | D001343;D059865 | T043;T049 |
34,685,711 | chaperon mediat autophagi marker lampa hspa advanc non small cell lung cancer neoadjuv therapi recent year autophagi attract attent research mani medic field includ cancer research certain anti macroautophagi drug combin cytotox target therapi enter clinic trial present studi focus less explor subtyp autophagi ie chaperon mediat autophagi cma key protein lampa hspa hsc immunohistochem evalu previous extens valid antibodi interest whether marker express influenc anteced therapi correl surviv cohort patient non small cell lung cancer nsclc neoadjuv therapi match primari resect tumor concord previous studi find intratumor heterogen correl two paramet correl marker includ patholog paramet surpris express marker also independ tumor respons administ neoadjuv treatment surviv analysi result signific lampa higher level associ longer year overal surviv diseas free surviv mix group adenocarcinoma squamous cell carcinoma p p respect well squamous cell carcinoma subgroup p p respect lampa also independ prognost marker univari multivari analysi | D000080642;D020360 | T043;T061 |
34,685,710 | cullin e ubiquitin ligas regul male gonocyt migrat prolifer blood testi barrier homeostasi ubiquitin essenti posttransl modif play fundament role mammalian spermatogenesi previous report requir two cullin ubiquitin ligas famili gene cullin cula cullin b culb murin spermatogenesi gene requir male fertil despit distinct function differ cell popul cula requir primari spermatocyt promot meiosi culb requir secondari spermatocyt spermiogenesi two gene encod protein high homolog overlap express embryon germ cell may compens germ cell develop present studi direct address potenti function redund two protein delet cul gene specif germ cell lineag embryon develop use germ cell specif vasa cre line condit doubl knockout dko male show delay home impair prolifer gonocyt complet loss germ cell end first wave spermatogenesi dko male germ cell phenotyp much sever observ either singl ko mutant demonstr function redund two cul protein dko mutant also exhibit atyp tight junction structur suggest potenti involv cul protein spermatogoni stem cell ssc nich format blood testi barrier btb mainten also show delet culb germ sertoli cell suffici recapitul part phenotyp caus spermatogenesi defect drastic reduc number matur sperm accompani defect tight junction mutant test result indic involv culb maintain btb integr | D002465 | T043 |
34,685,705 | role mir p regul cfl myogen differenti cc myoblast skelet myogenesi requir maintain muscl mass integr impair myogenesi causal link etiolog muscl wast recent shown excess uptak satur fatti acid sfa play signific role pathogenesi muscl wast although microrna mirna implic regul myogenesi molecular mechan wherebi sfa induc mirna impair myogen differenti remain larg unknown investig regulatori role mir p cfl express myogen differenti cc myoblast pa imped myogen differenti concomit suppress cfl induc mir p dual luciferas analysi reveal mir p direct target utr cfl therebi suppress express cfl crucial factor actin dynam transfect mir p mimic result accumul actin filament f actin nuclear yes associ protein yap myoblast promot myoblast prolifer cell cycl progress consequ mir p mimic signific attenu express myogen factor therebi impair myogen differenti myoblast role mir p cfl express f actin modul myogen differenti suggest novel mirna mediat regulatori mechan myogenesi pa induc mir p may critic mediat obes muscl wast | D005786 | T045 |
34,685,704 | ledgfp integras bind domain interactom contribut surviv clonogen tumorspher format docetaxel resist prostat cancer cell patient prostat cancer pca receiv docetaxel chemotherapi invari develop chemoresist transcript co activ len epithelium deriv growth factor p ledgfp also known dfs psip upregul sever human cancer includ pca promot resist docetaxel drug c termin region ledgfp contain integras bind domain ibd tether nuclear protein includ hiv integras transcript factor activ chromatin promot viral integr transcript cellular surviv gene investig contribut ledgfp ibd interactom pca chemoresist quantit immunoblot reveal ledgfp ibd interact partner endogen upregul docetaxel resist pca cell line compar docetaxel sensit parent cell use specif human autoantibodi co immunoprecipit ledgfp endogen ibd interact partner jpo menin mll iw ask pogz well transcript factor c myc hrp docetaxel resist cell confirm nuclear co local confoc microscopi deplet ledgfp select interact partner robust decreas surviv clonogen tumorspher format capac docetaxel resist cell result implic ledgfp ibd interactom pca chemoresist could lead novel therapeut strategi target protein complex treatment docetaxel resist tumor | D019008 | T042;T038 |
34,685,703 | iqsec defici result abnorm social behavior relev autism affect function neural circuit medial prefront cortex iqsec guanin nucleotid exchang factor gef adp ribosyl factor arf protein exclus local postsynapt densiti excitatori synaps human genom studi reveal iqsec gene associ x link neurodevelopment disord intellectu disabl id epilepsi autism studi examin behavior synaps function iqsec knockout ko mice generat use cripsrca mediat genom edit solv relev iqsec defici pathophysiolog neurodevelopment disord iqsec ko mice exhibit autist behavior overgroom social deficit identifi regul c fos express medial prefront cortex mpfc induc social stimul signific attenu iqsec ko mice whole cell electrophysiolog record identifi synapt transmiss mediat amino hydroxi methyl isoxazolepropion acid receptor ampar n methyl aspart receptor nmdar aminobutyr acid receptor gabar signific decreas pyramid neuron layer mpfc iqsec ko mice reexpress iqsec isoform mpfc iqsec ko mice use adeno associ virus aav rescu synapt social deficit suggest impair synapt function mpfc respons social deficit iqsec ko mice | D012919 | T054 |
34,685,700 | alveolar macrophag adapt anatom nich inflamm earli stage life develop alveoli colon embryon macrophag becom resid alveolar macrophag resam self sustain local divis genet epigenet signatur extent function resam dictat lung microenviron use cytokin ligand receptor interact stroma cell orchestr lung homeostasi rest condit lung microenviron induc resam tolerogen program prevent unnecessari potenti harm inflamm respons foreign bodi continu challeng airway throughout life episod acut inflamm pneumonia like frequent caus deplet pool resam leav space recruit inflammatori monocyt local develop monocyt deriv alveolar macrophag infam lung infect local microenviron induc temporari inflammatori signatur recruit infam handl tissu injuri elimin pathogen day recruit infam local self sustain develop new resam gain profibrot function requir tissu heal complet resolut infecti episod function program embryon monocyt deriv resam remain alter month possibl entir life adult lung thus contain wide divers resam sinc everi infect bring new wave infam fill room left open inflammatori process memori innat cell call train immun constitut immunolog scar left inflamm notabl pneumonia memori resam advantag drawback case lung train immun offer better defens capac autoimmun disord long term risk infect opposit perpetu harm process lead patholog state case among critic ill patient immun paralysi high suscept hospit acquir pneumonia acut respiratori distress syndrom progress understand kinet respons alveolar macrophag lung inflamm pave way new treatment pneumonia lung inflammatori process | D000222 | T040 |
34,685,699 | cycloastragenol triterpenoid saponin regul oxid stress neurotroph dysfunct neuroinflamm apoptot cell death neurodegen condit unveil effect cycloastragenol amyloid beta induc oxid stress neurogen dysfunct activ mitogen activ protein map kinas mitochondri apoptosi induc mous model alzheim diseas ad induc mous model develop stereotax inject amyloid beta gmouseintracerebroventricular cycloastragenol given dose mgkgdaypo week daili biochem analysi use immunofluoresc western blot find show inject elev oxid stress reduc express neurogen marker shown reduc express brain deriv neurotroph factor bdnf phosphoryl specif receptor tropomyosin receptor kinas b p trkb addit mark reduct express neun neuron nuclear protein inject mice brain cortex hippocampus interest express nrf nuclear factor erythroid relat factor ho heme oxygenas p trkb bdnf neun mark enhanc cycloastragenol co treat mice brain also evalu express map kinas phospho c jun n termin kinas p jnk p phospho extracellular signal relat kinas erk experiment group suggest express p jnk p p p erk signific upregul inject mice brain interest marker downregul cycloastragenol co treat mice brain also check express activ microglia inflammatori cytokin show cycloastragenol reduc activ microglia inflammatori cytokin moreov evalu effect cycloastragenol mitochondri apoptosi memori dysfunct experiment group find show signific regulatori effect apoptosi memori dysfunct reveal morri water maze mwm test collect find suggest cycloastragenol regul oxid stress neurotroph process neuroinflamm apoptot cell death memori impair mous model ad | D017209;D018384 | T043;T116;T049;T123 |
34,685,698 | identif tropic plant extract extend yeast chronolog life span certain plant extract pes contain bioactiv compound antioxid lifespan extend activ organ pes play differ role cellular process enhanc stress resist modul longev defin signal pathway contribut longev report discoveri pes extend chronolog life span cls bud yeast screen pes identifi two pes leaf extract manihot esculenta wodyetia bifurcata extend cls dose depend manner cls extend pes also confer oxid stress toler suggest pes might extend yeast cls upregul stress respons pathway | D014329 | T070 |
34,685,697 | effect periop lipid status clinic outcom cardiac surgeri patient undergo cardiac surgeri increas cardiovascular risk includ alter lipid status howev data effect cardiac surgeri cardiopulmonari bypass cpb plasma level key lipid scarc investig potenti effect cpb plasma lipid level associ earli postop clinic outcom prospect bio bank studi patient undergo elect cardiac surgeri center januari decemb follow period year surgeri blood sampl perform induct general anesthesia upon wean cardiopulmonari bypass cpb first day surgeri clinic end point includ incid postop stroke myocardi infarct death caus day surgeri well year caus mortal total cardiac surgeri patient male median age year interquartil rang median bmi kgm includ signific intraop decreas plasma level compar preoper level p observ total cholesterol tc cliff delta ci ldl cholesterol ldl c hdl cholesterol hdl c h surgeri plasma level ldl c tc continu decreas compar preoper level plasma level hdl c tg rebound remain preoper level p mortal day n year mortal n postop myocardi infarct occur patient n postop stroke n adjust age sex bmi statin therapi note protect effect postop occurr stroke pre post oper chang tc adjust odd ratio p ldl c aor p hdl c aor p associ observ lipid level year mortal conclus cardiac surgeri induc signific sudden drop level key plasma lipid effect pronounc oper level remain signific lower h surgeri intraop drop ldl c tc hdl c associ protect effect occurr postop stroke adjust model demonstr chang key plasma lipid level surgeri strong correl make attribut impact lipid clinic end point postop stroke challeng task larg scale analys investig addit clinic outcom measur | D006348;D019990 | T058;T061 |
34,685,696 | vaccin covid prioriti mrna base formul septemb twenti one anti covid vaccin approv world util expedit end current pandem besid usual vaccin format includ inactiv virus eight approv vaccin protein base vaccin four approv vaccin three new format valid recombin adenovirus six approv vaccin dna one approv vaccin messeng rna mrna two approv vaccin latter fastest author eu usa switzerland western countri reserv use protein vaccin adenovirus vaccin mrna vaccin describ differ vaccin format context covid detail three format chiefli reserv use europ canada usa discuss mrna vaccin appear superior format | D012333;D000086402 | T114;T005;T123 |
34,685,695 | recent therapeut approach modul hippo pathway oncolog regen medicin hippo pathway evolutionari conserv signal network regul essenti process organ size cell prolifer migrat stem apoptosi alter pathway common found solid tumor lead hyperprolifer resist chemotherapi compens mkras tumor immun evas termin effector hippo pathway transcript coactiv yaptaz transcript factor tead present excit opportun pharmacolog modul hippo biolog cancer set inflamm regen medicin review provid overview progress current strategi direct indirect target yaptaz protein protein interact ppi tead across multipl modal focus recent small molecul abl select bind tead block autopalmitoyl inhibit yaptaz tead depend transcript cancer | D008495;D044968;D015398 | T091;T044;T043 |
34,685,693 | ischemia reperfus injuri simul lung transplant set differenti regul transcriptom profil human lung endotheli epitheli cell current understand mechan ischemia reperfus induc lung injuri lung preserv transplant main base clinic observ anim studi herein use cell system biolog approach explor mechan transcriptom level especi focus differ human lung endotheli epitheli cell crucial maintain essenti lung structur function human pulmonari microvascular endotheli cell human lung epitheli cell cultur confluent subject differ cold ischem time cit mimic static cold storag preserv solut subject warm reperfus serum contain cultur medium simul lung transplant cell morpholog viabil transcriptom profil studi ischemia reperfus injuri induc cit time depend cell death associ dramat chang gene express normal control condit endotheli cell show gene cluster enrich vascular process inflamm epitheli cell show gene cluster enrich protein biosynthesi metabol cit h alon reperfus littl effect phenotyp characterist cit h protein biosynthesi relat gene cluster disappear epitheli cell reperfus metabol relat gene cluster epitheli cell multipl gene cluster endotheli cell also disappear human pulmonari endotheli epitheli cell distinct phenotyp transcriptom signatur sever cellular injuri reduc gene express signatur cell type depend manner therapeut preserv transcriptom signatur may repres new treatment prevent acut lung injuri lung transplant | D020869;D016040 | T059;T063;T061 |
34,685,691 | szt interactom unravel new function kicstor complex seizur threshold szt compon kicstor complex catabol condit function negat regul amino acid sens branch mtorc mutat gene caus sever neurodevelopment epilept encephalopathi whose main symptom includ epilepsi intellectu disabl macrocephali szt remain one least character regul mtorc work perform systemat interactom analysi catabol anabol condit besid numer mtorc ampk signal compon identifi cluster protein relat autophagi ciliogenesi regul neurogenesi neurodegen process moreov analysi szt ablat cell reveal increas mtorc signal activ could revers rapamycin torin treatment strike szt ko cell also exhibit higher level autophag compon independ physiolog condit test result consist interactom data detect enrich pool select autophagi receptorsregul moreov preliminari analys indic szt alter ciliogenesi overal data present form basi comprehens investig physiolog function szt could explain major molecular event pathophysiolog development epilept encephalopathi patient szt mutat | D060066 | T169 |
34,685,688 | magnet guid perman magnet concept realize applic nanoparticl cell idea remot magnet guid develop under physic concept allow biject forc generat inner volum magnet system concept equal implement electro perman magnet perman magnet focus offer mani advantag equat magnet field forc well veloc deriv detail physic limit discuss special hydrodynam nanoparticl dispers circumst review relat technic constraint possibl guid magnet imag techniqu discuss final first result guid macroscop object superparamagnet nanoparticl cell incorpor nanoparticl present construct magnet system allow orient movement acceler magnet object principl scale human size | D060328;D059346 | T070;T074;T073 |
34,685,687 | cisplatin reduc frequenc radiotherapi induc micronuclei peripher blood lymphocyt patient gynaecolog cancer possibl implic risk second malign neoplasm gynaecolog cancer common among women treatment includ surgeri radiotherapi chemotherapi last two method induc dna damag non target cell like peripher blood lymphocyt pbl damag normal cell transform lead second malign neoplasm smn level risk impact risk modifi well defin investig radiotherapi alon combin chemotherapi induc dna damag pbl cervix endometri cancer patient therapi blood sampl collect nine endometri cancer patient treatment radiotherapi chemotherapi rc nine cervic cancer patient treatment radiotherapi alon r radiotherapi week onset radiotherapi end radiotherapi half blood sampl irradi ex vivo gy gamma radiat order check therapi influenc sensit pbl radiat analys endpoint micronucleus mn frequenc apoptosi frequenc cell prolifer index result characteris strong individu variat especi mn frequenc prolifer index averag despit higher total dose larger field therapi alon induc level mn pbl rc patient compar r result accompani higher level apoptosi stronger inhibit cell prolifer rc patient ex vivo dose induc fewer mn apoptosi strong inhibit prolifer pbl rc compar r patient result interpret evid sensit effect chemotherapi radiat cytotox possibl implic risk second malign neoplasm discuss | D048629 | T026 |
34,685,685 | biochemistri pathophysiolog regul linear ubiquitin intric regul coordin function associ ligas deubiquitinas ubiquitin system modul protein function decor target protein ubiquitin chain case sever type ubiquitin chain exist chain type determin mode regul conjug protein lubac ubiquitin ligas complex specif generat n termin met link linear ubiquitin chain although linear ubiquitin chain much less abund type ubiquitin chain play pivot role cell surviv prolifer immun respons elimin bacteria select autophagi linear ubiquitin chain regul inflammatori respons control proinflammatori transcript factor nf b program cell death includ apoptosi necroptosi abnorm generat linear chain result pathogenesi lubac consist hoip hoil l sharpin hoip catalyt center linear ubiquitin lubac uniqu contain two differ ubiquitin ligas hoip hoil l ligas complex furthermor lubac constitut interact deubiquitin enzym dub otulin cyld cleav linear ubiquitin chain generat lubac review summar current status linear ubiquitin research discuss intric regul lubac mediat linear ubiquitin coordin function hoip hoil l ligas otulin furthermor discuss therapeut approach target lubac mediat linear ubiquitin chain | D054875 | T044 |
34,685,684 | apoptot cell trigger calcium entri phagocyt induc orai stim associ swift continu phagocytosi apoptot cell achiev modul calcium flux phagocyt howev molecular mechan apoptot cell modul calcium flux phagocyt incomplet understood use biophys biochem pharmaceut genet approach show apoptot cell induc orai stim interact lead store oper calcium entri soce phagocyt mertk phospholipas c plc inositol triphosph receptor ip r axi apoptot cell induc calcium releas endoplasm reticulum led orai stim associ consequ soce phagocyt associ attenu mask phosphatidylserin addit deplet mertk indirect sens phosphatidylserin apoptot cell reduc phosphoryl level plc ip r result attenu orai stim interact ineffici soce upon apoptot cell stimul taken togeth observ uncov mechan phagocyt engulf apoptot cell elev calcium level | D017209 | T043;T116;T123 |
34,685,683 | transcriptom biomark tuberculosi valid npc singl mrna biomark diagnos tb predict diseas progress monitor treatment respons extern valid differ cohort key step translat develop new biomark previous describ three host mrna whose express peripher blood signific higher npc lower dock epha individu tb compar latent tb infect ltbi control conduct independ valid gene analyz public avail transcriptom dataset brazil china haiti india south africa unit kingdom comparison tb controlltbi show signific differenti express three gene npchigh nbsp p docklow nbsp p ephalow nbsp p npchigh highest mean area roc curv auroc differenti tb vs control ltbi addit npc accur distinguish tb clinic similar condit pneumonia auroc non activ sarcoidosi lung cancer activ sarcoidosi interest individu progress ltbi tb show constant increas npc express time compar non progressor p signific chang closer manifest activ diseas month p moreov npc express normal complet anti tb treatment taken togeth result valid npc mrna diagnost host biomark activ tb independ host genet background moreov reveal potenti predict progress latent activ infect indic respons anti tb treatment | D018450 | T033;T046 |
34,685,682 | lineag select disturb earli human hematopoiet progenitor cell differenti common use plastic di ethylhexyl phthalat via reactiv oxygen speci fatti acid oxid make differ exposur ubiquit endocrin disrupt chemic edc major public health concern analyz physiolog impact edc di ethylhexyl phthalat dehp found metabolit mono ethylhexyl phthalat mehp signific advers effect myeloid hematopoiesi environment relev concentr analysi under mechan reveal mehp promot increas reactiv oxygen speci ros reduc activ superoxid dismutas lineag possibl via action aryl hydrocarbon receptor lead metabol shift away glycolysi toward pentos phosphat pathway ultim result death hematopoiet cell reli glycolysi energi product contrast cell util fatti acid oxid energi product suscept outcom due capac uncoupl atp product respons also detect non hematopoiet cell expos altern induc ros | D002454;D019070 | T043;T078 |
34,685,681 | enhanc express microrna g p contribut alzheim diseas pathogenesi regul express mitochondri gene alzheim diseas ad common form dementia elder popul under caus fulli elucid recent studi shown microrna mirna play import role regul express level gene associ ad develop studi analyz mirna plasma cerebrospin fluid csf ad patient cognit normal includ amyloid posit individu mir g p identifi ad associ mirna found elev csf earli stage ad patient overexpress mir g p enhanc amyloid beta product induc oxid stress mitochondri impair ad model cell line biotin streptavidin pull assay demonstr mir g p primarili interact mitochondri gene express downregul mir g p particular mir g p target gene timm show reduc express brain tissu human ad patient result suggest mir g p express earli stage ad notabl contribut product mitochondri impair thus mir g p might biomark earli diagnosi ad potenti therapeut target prevent ad progress | D005786;D050259 | T028;T045 |
34,685,680 | map proxim interact network stim reveal new mechan cytoskelet regul stromal interact molecul stim resid primarili sarcoendoplasm reticulum sens intralumin ca level activ orai channel plasma membran initi ca influx previous shown stim involv dynam remodel actin cytoskeleton howev downstream effector stim lead cytoskelet remodel known proxim label techniqu bioid captur weak transient protein protein interact includ protein resid close vicin bait may direct binder henc present studi investig stim interactom use bioid techniqu promiscu biotin ligas fuse cytoplasm c terminus stim stabli express mous embryon fibroblast mef cell line screen biotinyl protein identifi sever high confid target report gelsolin gsn new member stim interactom gsn ca depend actin sever protein promot actin filament assembl disassembl result valid use knockdown approach immunostain test result neonat cardiomyocyt stim overexpress induc alter actin dynam cytoskelet instabl first time bioid assay use investig stim interactom work highlight role stimgsn structur function cytoskeleton | D025941;D060066 | T169;T063 |
34,685,679 | complex metabol network confer immunosuppress function myeloid deriv suppressor cell mdscs within tumour microenviron myeloid deriv suppressor cell mdscs constitut plastic heterogen cell popul among immun cell within tumour microenviron tme support cancer progress resist therapi tumour progress cancer cell modifi metabol sustain increas energi demand cope uncontrol cell prolifer differenti metabol reprogram cancer establish competit nutrient tumour cell leukocyt import among tumour infiltr immun cell thus mdscs emerg one decis immun regul tme exhibit increas glycolysi fatti acid metabol also upregul enzym catabolis essenti metabolit complex metabol network crucial mdsc surviv accumul tme also enhanc immunosuppress function toward immun effector review discuss recent progress field mdsc associ metabol pathway could facilit therapeut target cell cancer progress | D007165;D053858 | T044;T169;T061 |
34,685,678 | har power induc pluripot stem cell gene edit technolog therapeut implic hematolog malign vitro model hematolog malign provid insight influenc genet aberr cellular molecular mechan involv diseas progress also aid develop evalu therapeut agent owe self renew differenti capac induc pluripot stem cell ipsc emerg potenti sourc short suppli diseas specif human cell hematopoiet lineag patient deriv ipsc recapitul diseas sever spectrum prognosi dictat genet variat among patient use drug screen studi clonal evolut howev approach lack abil model earli phase diseas lead cancer advent genet edit technolog promot generat precis isogen ipsc diseas model address question regard under genet mechan diseas initi progress review discuss use ipsc diseas model hematolog diseas lack patient sampl avail andor difficulti engraft generat anim model furthermor describ power combin ipsc precis gene edit elucid under mechan initi progress various hematolog malign final discuss power ipsc diseas model develop test novel therapi high throughput set | D000072669 | T063 |
34,685,674 | integr cghwes analys advanc understand aggress neuroblastoma evolut case studi neuroblastoma nb common extra cranial malign preschool children portray genet landscap over aggress nb lead rapid clinic progress diseas tumor dna collect pre post treatment analyz array compar genom hybrid acgh whole exom sequenc wes pharmacogenet approach respect identifi relev copi number alter cnas singl nucleotid variant snvs polymorph snps combin integr analysi spontan form tumoroid obtain recurr mass also character result prove power combin cnas snvs snps analys assess clonal evolut diseas progress evidenc multipl clone diseas onset dynam genom alter therapi administr propos molecular cytogenet integr analysi empow diseas follow predict tumor recurr | D055028;D000073359 | T063 |
34,685,673 | matern b cell intrins myd signal mediat lps driven intrauterin fetal death immunolog network balanc toler toward patern alloantigen pregnanc normal immun respons pathogen subclin infect impact balanc lead preterm birth even intrauterin fetal death iufd recent show loss matern b cell render murin fetus suscept iufd lps exposur sinc signal pathway involv b cell mediat respons remain unclear aim understand particip myd respons use b cell specif myd defici bmyd mice b cell isol wild type wt bmyd cd myd dam gestat day gd respond differ lps concern cytokin secret vivo lps challeng gd provok iufd cd mother function myd fetus bmyd myd mice protect outcom associ alter cytokin level matern serum chang cd cell respons overal loss myd signal matern b cell prevent activ cytokin releas lead iufd thus myd signal matern b cell protect mother infect ultim kill fetus understand cellular mechan under infect driven pregnanc complic first step design power therapeut strategi futur | D015398 | T043;T044 |
34,685,672 | nematostella vectensi emerg model deciph molecular cellular mechan under whole bodi regener capac regener lost injur bodi part widespread featur within metazoan intrigu scientist centuri one extrem type regener call whole bodi regen capac enabl regener fulli function organ isol bodi part exclus habitat whole bodi regener widespread aquaticmarin invertebr past decad new whole bodi research model emerg complement histor model hydra planarian among sea anemon nematostella vectensi attract increas interest regard deciph cellular molecular mechan under whole bodi regener process manuscript present overview biolog featur anthozoan cnidarian well avail tool resourc develop scientif communiti studi nematostella review current understand cellular molecular mechan under whole bodi regener marin organ emphasi compar embryon develop regener organ provid insight regener specif element | D023421 | T008 |
34,685,670 | myricetin galactopyranosid exhibit potenti anti osteoporot properti human bone marrow deriv mesenchym stromal cell via stimul osteoblastogenesi suppress adipogenesi natur bioactiv substanc promis lead compound benefici effect various health problem includ osteoporosi context goal studi investig effect myricetin galactopyranosid mg glycosid known bioactiv phytochem myricetin bone format via osteogen differenti human bone marrow deriv mesenchym stromal cell hbm mscs hbm mscs induc differenti osteoblast adipocyt presenc absenc mg differenti marker analyz osteoblastogenesi induc cell treat mg exhibit stimul differenti marker cell prolifer alkalin phosphatas alp activ extracellular miner term intracellular signal behind stimulatori effect mg express runx osteopontin transcript factor upregul shown mg treatment increas activ wnt bmp suggest mechan action effect hand mg treatment adipogenesi induc hbm mscs hinder adipogen differenti shown decreas lipid accumul express ppar srebpc cebp adipogen transcript factor conclus mg treatment stimul osteoblast differenti inhibit adipocyt differenti induc hbm mscs osteoblast format stimul via wntbmp adipogenesi inhibit via ppar pathway studi provid necessari data studi util therapeut potenti mg osteoporosi via regul bone marrow stromal cell differenti | D050156;D010012 | T044;T042 |
34,685,668 | loganin amelior pain diabet neuropathi modul oxid stress inflamm insulin sensit streptozotocin nicotinamid induc diabet rat loganin iridoid glycosid antioxid anti inflammatori glucos lower activ may address patholog mechan pain diabet neuropathi pdn relat inflamm oxid stress hyperglycemia studi investig under mechan action loganin pdn vivo model pdn establish streptozotocin nicotinamid stz na induct spragu dawley sd rat subsequ loganin mgkg administ daili intraperiton inject high glucos stimul human sh syy cell co incub loganin use mimic vitro model pdn loganin improv pdn rat associ pain behavior allodynia hyperalgesia insulin resist index homa ir serum level superoxid dismutas sod catalas glutathion loganin also reduc pain associ channel protein ca v calcitonin gene relat peptid cgrp surfici spinal dorsal horn pdn rat loganin inhibit oxid stress nf b activ decreas level mrna protein proinflammatori factor il tnf moreov loganin attenu insulin resist modul jnk ir insulin receptor substrat akt gsk signal pathway pdn rat result suggest loganin improv pdn mediat pain behavior inhibit oxid stress provok inflamm spinal cord result improv neuropath pain | D007333;D018384 | T049;T046 |
34,685,667 | clinic applic cell scaffold construct bone regener therapi bone tissu engin bte process combin live osteoblast progenitor biocompat scaffold produc biolog substitut integr host bone tissu recov function mesenchym stem cell mscs research post natal stem cell self renew properti multi differenti capac give rise various cell lineag includ osteoblast bte technolog util combin mscs biodegrad scaffold materi provid suitabl environ function bone recoveri develop therapeut approach bone regener although prior clinic trial bte approach shown promis result regener larg bone defect still unmet medic need patient suffer signific loss bone function present review discuss osteogen potenti mscs bone tissu engin propos use immatur osteoblast differenti osteoblast upon transplant altern cell sourc regener larg bone defect | D023822 | T061 |
34,685,661 | stem cell research tool human metabol disord overview metabol disord common popul worldwid among diseas highest health util cost per person despit ongo effort develop new treatment current mani disord approv therapi result huge econom hit tension societi review recapitul recent advanc stem cell gene therapi potenti tool long term treatment inherit lysosom storag diseas acquir diabet mellitus obes metabol disord focus main promis result observ human patient discuss critic hurdl prevent definit jump approach bench clinic | D057905 | T062 |
34,685,658 | analysi gene express pattern epigenet enzym dnmta tet ogt murin chondrogen model investig gene express pattern select enzym involv dna methyl effect dna methyl inhibitor azacytidin vitro vivo cartilag format base data pcr array perform chondrifi bmp overexpress cht cell relat express tet tet methylcytosin dioxygenas dnmta dna methyltransferas ogt link n acetylglucosamin transferas examin rt qpcr murin cell line base primari chondrifi micromass cultur found strong gradual decreas express tet throughout entir cours vitro cartilag differenti along strong signal cartilagin embryon skeleton use specif rna probe situ hybrid frozen section day old mous embryo dnmta ogt express show signific chang rt qpcr gave weak situ hybrid signal dna methyl inhibitor azacytidin reduc cartilag specif gene express cartilag format appli earli stage chondrogenesi contrast stimulatori effect ad differenti chondrocyt quantit methyl specif pcr prove dna methyl pattern key chondrogen marker gene alter treatment result indic dna demethyl induc tet play signific role chondrogenesi inhibit dna methyl exert distinct effect differ phase vitro cartilag format | D044127 | T045 |
34,685,657 | integu specif transcript regul mid stage flax seed develop influenc releas mucilag seed oil content flax linum usitatissimum l seed oil accumul embryo mucilag synthes seed coat great econom import food pharmaceut well chemic industri theori link oil mucilag product seed consist spatio tempor competit compound photosynth earli stage seed develop studi demonstr posit relationship seed oil product seed coat mucilag extrus agronom model flax three recombin inbr line select low medium high mucilag seed oil content metabolit transcript profil h nmr dna oligo microarray perform seed seed develop analys show main chang seed coat transcriptom mid phase seed develop day post anthesi mucilag biosynthesi modif process thought finish transcriptom chang compris gene putat involv mucilag chemic modif oil synthesi well gibberel acid ga metabol result integr biolog approach suggest transcript regul seed oil fatti acid fa metabol could occur seed coat mid stage seed develop seed coat carbon suppli use mucilag biosynthesi mechanochem properti mucilag secretori cell | D018507;D018506;D014158 | T045 |
34,685,655 | mechan stem cell therapi spinal cord injuri everi year million peopl worldwid suffer spinal cord injuri sci irretriev sequela rehabilit current avail treatment restor damag tissu therefor function recoveri patient remain limit pathophysiolog spinal cord injuri heterogen impli potenti therapeut target differ depend time injuri onset degre injuri spinal level injuri recent year despit signific number clinic trial base various type stem cell aspect injuri effect consid result difficult outcom trial specialti cancerolog precis medicin base patient characterist brought indisput therapeut advanc object present review promot develop precis medicin field sci first describ multifacet pathophysiolog sci tempor chang injuri characterist chronic phase subtyp complet injuri detail appropri target relat mechan differ type stem cell therapi patholog condit final highlight great potenti stem cell therapi cervic sci | D033581 | T061 |
34,685,654 | inhibitori receptor gpr adgrg specif express tissu resid memori cell mice dispens differenti function vivo tissu resid memori rm cell potent antivir antibacteri function protect epitheli mucos surfac bodi infect pathogen strong proinflammatori activ rm cell suggest requir express inhibitori molecul restrain memori cell steadi state condit previous identifi adhes g protein coupl receptor gpr inhibitori receptor human cytotox lymphocyt regul cytotox effector function explor express pattern express regul function gpr pathogen specif cd cell use two infect model observ gpr express rm cell acut infect upregul rm cell induc cytokin tgf rm cell associ transcript factor hobit howev gpr appear dispens cd cell differenti function upon acut infect lcmv well listeria monocytogen thus rm cell specif acquir inhibitori receptor gpr impact receptor rm cell acut infect appear essenti regul effector function rm cell | D007156 | T042 |
34,685,653 | silico evalu natur compound acid extracellular environ human breast cancer surviv rate breast cancer bc improv recent year resist metastasi recurr still remain major therapeut challeng bc acid tumor microenviron tme attract attent associ tumorigenesi metastasi drug resist immun surveil studi evalu natur compound tradit herbal medicin use treat cancer select target gene regul extracellular acidosi integr four transcriptom data includ bc prognost data cancer genom atlas databas gene express profil mcf cell treat natur compound pattern gene profil acid condit singl cell rna sequenc bc patient sampl brucein bd predict highest therapeut potenti inform gain ig score regul reprogram gene driven acidosi affect surviv bc patient bd show highest ig emt ig score invas ig score compar phenotyp cancersea databas bd also demonstr therapeut potenti interf tumor cell tme interact reduc amyloid beta precursor protein cd express therefor bd potenti candid target acid tme induc metastat process bc | D003198 | T066 |
34,685,652 | autophagi tumor immun viral base immunotherapeut approach cancer autophagi fundament catabol process essenti mainten cellular tissu homeostasi well direct contribut control invad pathogen unsurpris process becom critic support cellular dysregul occur cancer particular tumor microenviron immun cell infiltr ultim play role respons cancer therapi therefor understand cancer autophagi could help turn cellular wast manag servic power alli specif therapeut instanc numer regulatori mechan autophag machineri contribut anti tumor properti oncolyt virus ov compris divers class replic compet virus potenti cancer immunotherapeut context autophagi either promot ov anti tumor effect enhanc infect replic mediat oncolysi induc autophag immunogen cell death reduc ov cytotox provid surviv cue tumor cell properti make catabol process autophagi attract target therapeut combin look enhanc efficaci ov articl review complic role autophagi cancer initi develop effect modul ov immun discuss recent progress opportunitieschalleng target autophagi enhanc oncolyt viral immunotherapi | D001343;D007167 | T043;T061 |
34,685,649 | ikknf b activ astrocyt reduc amyloid deposit process associ specif microglia polar alzheim diseas ad common neurodegen diseas accompani pronounc neuroinflammatori respons main character mark microgliosi astrogliosi howev remain open differ aspect astrocyt microgli activ affect diseas progress previous found microglia expans spinal cord initi ikknf b activ astrocyt exhibit stage depend benefici effect progress amyotroph later sclerosi investig impact nf b initi neuroinflamm ad pathogenesi use app mous model ad combin condit activ ikknf b signal astrocyt show nf b activ astrocyt trigger distinct neuroinflammatori respons character strike astrogliosi well promin microgli reactiv immunohistochemistri congo red stain reveal overal reduct size number amyloid plaqu cerebr cortex hippocampus interest isol primari astrocyt microglia cell exhibit specif marker gene profil case microglia point enhanc plaqu clearanc capac contrast direct ikknf b activ microglia result pro inflammatori polar program find suggest ikknf b signal astrocyt may activ paracrin mechan act microglia function also app process neuron | D016764 | T082 |
34,685,648 | integr proteom transcriptom analysi gonad reveal disrupt germ cell prolifer divis energi storag glycogen steril triploid pacif oyster crassostrea giga triploid oyster poor gonad develop bring higher econom benefit also potenti applic genet contain aquacultur howev key factor influenc germ cell develop triploid oyster remain unclear studi data independ acquisit coupl transcriptom appli identifi genesprotein relat steril triploid crassostrea giga eighti four gene differenti express protein mrna level fertil steril femal male oyster gene differenti express transcriptom proteom analysi larg proport downregul gene relat cell divis may hinder germ cell prolifer caus apoptosi steril triploid femal primari caus steril may downregul express level certain mitot cell cycl relat gene steril triploid male downregul gene relat cell cycl sperm motil indic disrupt mitosi meiosi flagella defect may link block spermatogenesi addit gene upregul steril oyster main associ biosynthesi glycogen fat suggest steril triploid stimul synthesi glycogen energi conserv gonad tissu | D004734;D020869;D040901;D057885 | T047;T039;T091;T040;T059;T063 |
34,685,647 | neutrophil extracellular trap dnase balanc autoimmun neutrophil extracellular trap net macromolecular structur program trap circul bacteria virus accumul net circul correl format anti doubl strand ds dna antibodi consid causat factor system lupus erythematosus sle digest dna dnase dnasesl rate limit factor net accumul mutat occur one two dnase gene determin anti dna format associ sever lupus like syndrom lupus nephriti ln second mechan may lead dnase function impair presenc circul dnase inhibitor patient low dnase activ generat anti dnase antibodi phenomenon describ relev number patient sle may repres import mechan determin autoimmun flare basi review studi tempt suppos blockad select deplet anti dnase autoantibodi could repres potenti novel therapeut approach prevent halt sle ln general strategi aim reduc net format might similar impact progress sle ln | D015551 | T046 |
34,685,645 | prognost signific dysregul epigenom chromatin modifi cervic cancer broaden understand epigenom chromatin regul cervic cancer examin status signific set epigenom chromatin modifi cervic cancer use comput biolog observ epigenom andor chromatin regul differenti upregul human cancer includ upregul invas squamous cell carcinoma cervic intraepitheli neoplasia cin upregul cervic intraepitheli neoplasia cin interest regul uniqu upregul cervic cancer ovarian endometri cancer observ overexpress regul found prognost signific cervic cancer collect overexpress regul well subset belong specif histon modif correspond top ten posit co overexpress gene correl reduc surviv patient high express test overexpress regul compar case low express use cell depend dataset human cervic cancer cell found epigenom chromatin regul studi appear essenti gene deplet gene accompani loss cellular viabil brief result present provid insight role epigenom chromatin regul oncobiolog cervic cancer broaden list new potenti molecul therapeut import | D057890 | T091 |
34,685,644 | role insulin like growth factor igf control neuroendocrin regul growth mammal neuroendocrin system includ communic hypothalamus pituitari play major role control bodi growth cellular metabol gh produc pituitari somatotroph consid master regul somat develop involv direct indirect carbohydr lipid metabol via complex yet well defin signal pathway gh product pituitari gland primarili regul counter regulatori effect hypothalam ghrh sst hormon role igf feedback regul gh product demonstr pharmacolog intervent genet modifi mous model present review discuss role igf regul gh axi control somat growth metabol homeostasi present genet modifi mous model maintain integr ghghrh axi singl except igf receptor igf r defici hypothalam ghrh neuron somatotroph reveal novel mechan control adipos tissu physiolog energi expenditur | D048788 | T040 |
34,685,643 | role extracellular vesicl cell death inflamm extracellular vesicl ev identifi novel mediat intercellular communic work via deliv sequest cargo cell close vicin well distant site bodi regul pathophysiolog process cell death inflamm biolog crucial process normal physiolog patholog process indistinguish link effector modul process instanc unresolv infect upregul specif immun mediat lead inflamm caus cell death tissu damag ev gain consider interest mediat cell death inflamm condit sepsi review summar type extracellular vesicl known date role mediat immun respons lead cell death inflamm specif focus sepsi lung inflamm | D017209;D016923;D000086402 | T043;T116;T005;T123 |
34,685,642 | review bioeffect static magnet field oral tissu deriv cell applic regen medicin magnet wide use dentistri orthodont tooth movement dentur retent nevertheless critic arisen regard biosafeti static magnet field smf effect surround tissu various controversi piec evid discuss regard smfs cellular biophys littl consensus reach especi field dentistri thus present paper first review safe use smfs oral caviti addit therapi orthodont tooth movement periodontium regener studi regard smf incorpor implant review investig advantag effect smfs osseointegr under mechan final review current develop dentistri surround combin magnet nanoparticl mnps smfs made clarifi potenti futur clinic applic | D060526;D044968 | T091;T070 |
34,685,641 | influenc age breed bovin ovarian capillari blood suppli ovarian mitochondria telomer length worldwid dairi cow type high produc cattl hpc suffer health fertil problem young age therefor lose product averag three lactat still contenti whether problem primarili due genet manag feed factor vascular play fundament role cyclic process reproduct organ well regener tissu previous studi hpc shown greater ovarian corpus luteum vascular compar dual purpos breed hypothes activ angiogenesi could like lead earli exhaust hpc regen capac thus prematur reproduct senesc object studi investig hpc breed holstein friesian hf exhibit higher ovarian angiogenesi dual purpos breed polish red cow pr relat earli ovarian age final reproduct failur purpos assess degre vascular mean ovarian blood vessel character use light microscopi indic age measur ovarian mitochondri size telomer length peripher leukocyt report studi breed distanc capillari becam smaller increas age mean telomer length decreas increas age differ two breed pr develop larger capillari hf neither relationship telomer length morpholog mitochondri apparatus angiogenesi hf proven although data trend indic proport shorten telomer hf higher pr signific differ two breed detect | D001947;D059505 | T040;T043;T045 |
34,685,638 | sp serin proteas gut microbiota influenc coliti drive intestin dysbiosi mice increas proteas activ link pathogenesi ibd studi focus host proteas gut inflamm remain unclear address potenti contribut bacteri counterpart present studi report function character newli identifi serin proteas sp human gut microbiota serin proteas repertoir gut clostridium first explor specif sp analyz use combinatori chemistri method combin vitro analys mous model coliti show oral administr recombin bacteria secret sp compromis epitheli barrier ii alter microbi communiti ii exacerb coliti find suggest gut microbi proteas activ may constitut valuabl contributor ibd could therefor repres promis target treatment diseas | D000069196 | T007;T001 |
34,685,636 | oxysterol hydroxylas cypb attenu metabol associ fatti liver diseas mice thermoneutr ambient temperatur import determin altern bile acid synthesi pathway control oxysterol hydroxylas cypb progress metabol associ fatti liver diseas mafld investig whether cypb involv etiolog mafld condit low high energi expenditur cypb wild type wt mice fed cholin defici high fat diet hous either c thermoneutr c mild cold studi diseas phenotyp under mechan plasma organ sampl analyz determin metabol paramet immun cell infiltr immunohistolog flow cytometri lipid speci includ hydroxycholesterol bile acid structur lipid wt cypb mice thermoneutr hous promot mafld effect pronounc cypb defici mice mice found higher plasma alanin aminotransferas activ hyperlipidemia hepat accumul potenti harm lipid speci aggrav liver fibrosi increas inflamm immun cell infiltr bile acid hydroxycholesterol correl aggrav mafld cypb mice hous thermoneutr notabl regul lipoprotein receptor detect c c liver cypb mice suggest acceler metabol lipoprotein carri lipotox molecul counteract mafld progress | D013696 | T081 |
34,685,632 | usp oncogen tumor suppressor unifi paradigm squamous cell carcinoma squamous cell carcinoma therapeut challeng tumor entiti low respons rate radiotherapi chemotherapi common observ squamous patient accord mortal rate relat high compar tumor entiti recent target usp emerg potenti altern improv therapeut respons clinic outcom squamous patient usp catalyt activ deubiquitinas govern plethora biolog process includ cellular prolifer dna damag repair apoptosi oncogenesi squamous cell carcinoma usp strong express stabil essenti squamous transcript factor np togeth import oncogen factor notch c myc c jun presum usp oncoprotein howev recent data suggest deubiquitinas also antineoplast effect regul import tumor suppressor protein p chk review discuss emerg role usp cancer complex mutat landscap squamous tumor genet alter cellular pathway determin function usp squamous cancer develop current state novel usp inhibitor | D016147;D009857 | T028 |
34,685,631 | oxytocin posit alloster modul opioid receptor opioid receptor g protein signal pathway oxytocin ot influenc various physiolog function uterin contract maternalsoci behavior analgesia opioid signal pathway involv one analges mechan ot previous show ot act posit alloster modul pam enhanc opioid receptor mor activ studi focus opioid receptor subtyp investig whether ot influenc opioid signal pathway pam dor kor use human embryon kidney cell express human dor kor respect cellkey tm result show ot enhanc imped induc endogenousexogen kor agonist kor express cell ot affect dor activ induc endogenousexogen dor agonist ot potenti kor agonist induc gio protein mediat decreas intracellular camp affect increas kor intern caus kor agonist dynorphin u hydrochlorid u ot bind kor orthoster bind site affect bind affin dynorphin u kor result suggest ot pam kor mor enhanc g protein signal without affect arrestin signal thus ot potenti specif signal bias pam kor | D015398 | T043;T044 |
34,685,630 | cytogenet evid clarifi phylogeni famili rhynchocyclida ave passeriform phylogenet posit taxonom status rhynchocyclida ave passeriform subject debat sinc first descript model rhynchocyclida repres subfamili level taxon place within tyrant flycatch tyrannida consid classif includ cytotaxonom charact test hypothesi chromosom organ rhynchocyclida member differ tyrannida henc select two speci tolmomyia sulphurescen pitangus sulphuratus repres rhynchocyclida tyrannida respect result reveal diploid number n sulphurescen n p sulphuratus indic signific chromosom differ chromosom map gallus gallus gga taeniopygia guttata bacteri artifici chromosom bac correspond chromosom gga except reveal genom evolut sulphurescen involv extens chromosom fusion macrochromosom microchromosom hand p sulphuratus retain ancestr pattern organ macrochromosom except centric fission involv gga microchromosom conclus compar result previous studi tyrant flycatch alli indic p sulphuratus similar karyotyp tyrannida member howev sulphurescen resembl tyrannida famili reinforc famili status clade name rhynchocyclida | D020732;D010802 | T062;T063;T078 |
34,685,629 | n myc downstream regul gene ndrg function posit regul apoptosi new insight ndrg tumor suppressor n myc downstream regul gene ndrg tumor suppressor gene increas tumor sensit anticanc drug slow tumor progress inhibit metastasi ndrg suppress various aggress tumor posit wherea ndrg express associ patient prognosi improv surviv rate review summar tumor suppressor mechan ndrg provid inform function ndrg concern suscept cell apoptosi ndrg increas suscept apoptosi various physiolog environ cell develop hypoxia nutrient depriv cancer drug treatment although molecular cell biolog mechan ndrg fulli elucid provid inform mechan ndrg relat apoptosi various environ review assist design research regard ndrg function suggest potenti ndrg molecular target cancer patient | D017209 | T043;T116;T123 |
34,685,626 | molecular basi domin sar cov spike deriv epitop present hla recognis public tcr data current avail immun system recognis sar cov virus grow rapid structur sar cov protein complex antibodi help us understand immun system abl recognis new virus howev lack data cell abl recognis virus cell especi cytotox cd cell critic viral recognit clearanc report x ray crystallographi structur cell receptor share among unrel individu public tcr complex domin spike deriv cd cell epitop ylq peptid show ylq activ polyfunct cd cell respons covid recov patient detail molecular basi share tcr gene usag observ hla individu provid understand tcr recognit toward sar cov epitop interest ylq peptid conform chang upon tcr bind facilit high affin interact observ | D000086402 | T005 |
34,685,625 | adipos tissu deriv mesenchym stem cell mediat pd l overexpress white adipos tissu obes individu result cell dysfunct pd lpd immun checkpoint axi strongest cell exhaust induc immun dysfunct occur obes analyz impact obes pd lpd express white adipos tissu wat mice human white adipocyt found pd l overexpress wat diet induc obes mice associ increas express pd viscer subcutan wat human vitro cocultur adipos tissu deriv mesenchym stem cell asc mononuclear cell demonstr presenc asc harvest obes wat enhanc pd l express compar asc lean wat ii decreas th cell cytokin secret iii result decreas cytolyt activ toward adipocyt moreov iv implic pd l obes asc mediat cell dysfunct demonstr pd l blockad final v condit media gather cocultur enhanc pd l express fresh differenti adipocyt depend ifn altogeth result suggest pd l overexpress wat obes individu ifn secret lead cell dysfunct notabl reduc cytolyt activ mechan could shed light adipos tissu infiltr virus sar cov worsen diseas obes individu | D005786 | T045 |
34,685,624 | dysfunct glutam delta receptor cerebellin tran synapt signal central amygdala chronic pain chronic pain debilit condit involv neuron dysfunct synapt mechan under persist pain still poor understood found synapt organ glutam delta receptor glud express postsynapt parabrachio central laterocapsular amygdala pb celc glutamaterg synaps axo somat punctat locat protein kinas c posit pkc neuron delet glud impair excitatori neurotransmiss pb celc synaps inflammatori neuropath pain model glud partner cerebellin cbln downregul ampa receptor upregul singl infus recombin cbln central amygdala led sustain mitig behavior pain paramet normal hyperexcit central amygdala neuron cbln ineffect condit effect cbln antagon glud ligand serin behavior effect cbln glud depend show later right central amygdala select ablat glud central amygdala inject cbln central amygdala normal anim led chang avers fear learn behavior thus glud cbln signal central amygdala teach signal avers behavior sustain dysregul under persist pain signific statement chronic pain debilit condit involv synapt dysfunct under mechan fulli understood studi identifi novel mechan involv structur synapt chang amygdala caus impair glud cbln signal inflammatori neuropath pain behavior also identifi novel mean mitig pain condit use protein therapeut | D015398 | T043;T044 |
34,685,623 | haskap berri phenol subclass differenti impact cellular stress sens primari immort dermal fibroblast general accept dietari phenol fruit signific import human health unfortun minim publish data differ phenol structur impact biolog pathway cellular molecular level observ haskap berri extract isol ethanol formic acid water phenol subclass fraction separ use differ concentr ethanol impact cell growth posit manner fraction extract signific increas popul doubl time extract fraction reduc intracellular free radic howev differ effect indic differ abil scaveng free radic extract fraction also exhibit differ impact transcript encod antioxid enzym cat sod gpx gss hmox phosphoryl state nuclear factor b nf b observ extract fraction contain differ phenol structur diverg impact mammalian target rapamycin mtor sirtuin sirt sirna mediat knockdown sirt transcript demonstr enzym key elicit haskap phenol impact cell postul phenol synerg signific import evalu dietari impact | D013312 | T121;T039;T046;T032;T040 |
34,685,622 | pro surviv octstatmcl axi associ poor prognosi lung adenocarcinoma patient embryon stem cell marker oct express sever human cancer posit correl poor outcom cancer patient howev physiolog role cancer progress remain poor understood tumor cell block apoptosi escap cell death prolifer indefinit lead ineffect therapi cancer patient studi investig whether oct regul apoptosi pathway contribut poor prognosi patient lung adenocarcinoma result reveal oct express correl stat express lung adenocarcinoma patient oct direct bound stat promot transactiv stat lung adenocarcinoma cell express stat downstream gene mcl increas oct overexpress cancer cell stat knockdown oct overexpress cancer cell sensit cisplatin induc apoptosi furthermor oct promot stat express tumor growth wherea silenc stat reduc oct induc tumor growth human lung tumor xenograft model taken togeth demonstr oct pro surviv factor induc stat express octstatmcl axi may potenti therapeut target lung adenocarcinoma | D015398 | T043;T044 |
34,685,621 | metabol stress adapt underli mammari gland morphogenesi breast cancer progress breast cancer display dynam reprogram metabol activ cancer develop premalign lesion primari tumor metastas numer advanc focus tumor develop pro prolif metabol signal differ adjac non transform epitheli tissu lead target oncogen driven liabil among breast cancer subtyp advanc demonstr microenviron trigger stress respons singl cell resolut microenvironment heterogen give rise cell regulatori state cancer cell spheroid three dimension cultur stratifi termin end bud mammari gland morphogenesi stress surviv signal juxtapos cell state specif stress signal network recaptur metabol evolut cancer progress understand lineag specif metabol phenotyp experiment model use gain deeper understand subtyp select breast cancer metabol | D000222;D018450;D009024;D013312 | T121;T039;T046;T032;T040;T033 |
34,685,620 | bmp attenu inflamm induc pyroptosi improv cardiac repair diabet cardiomyopathi present studi investig novel signal target diabet cardiomyopathi inflamm induc caspas depend cell death pyroptosi involv nek gbp activ activ nlrp inflammasom destabil cardiac structur neovascular furthermor explor therapeut abil bone morphogenet protein bmp attenu advers effect cblj mice n micegroup divid control mgkg salin intraperiton inject ip streptozotocin stz stz bmp group stz mgkg ip inject week heart function examin echocardiographi mice sacrif immunostain western blot h e masson trichrom stain perform heart tissu stz induc diabet cardiomyopathi signific increas inflammasom format tlr nlrp nek gbp pyroptosi marker caspas il il inflammatori cytokin il tnf mmp infiltr monocyt cd macrophag ino dendrit cell cdb cdc p moreov signific endotheli progenitor cell epc dysfunct c kitflk cd advers cardiac remodel reduct left ventricular lv heart function observ stz versus control p treatment bmp signific reduc inflammasom format pyroptosi inflammatori cytokin infiltr inflammatori cell addit bmp treatment enhanc epc marker neovascular subsequ improv cardiac remodel diabet heart moreov signific improv lv heart function achiev bmp administr relat diabet mice p conclus bmp attenu inflamm induc pyroptosi advers cardiac remodel improv heart function via tlr nlrp inflammasom complex activ novel signal nekgbp bmp pre clinic studi mice could signific potenti futur therapi diabet patient | D000069292 | T043 |
34,685,619 | cdk mediat phosphoryl bag promot mitot cell shape remodel molecular assembl mitot p bodi cochaperon bcl associ athanogen bag complex heat shock protein hspb facilit mitot round spindl orient proper absciss daughter cell bag hspb mitot function implic sequestosom psqstm suggest role protein qualiti control howev interplay chaperon assist pathway mitot machineri known show bag phosphoryl conserv regul cdk activ function mitot cell shape remodel bag phosphoryl exhibit high dynam mitot entri non phosphorylat bag ta phosphomimet bag td protein unabl correct mitot defect bag deplet hela cell also demonstr bag phosphoryl hspb cdk activ modul molecular assembl psqstm mitot bodi contain k polyubiquitin chain find suggest exist mitot regul spatial qualiti control mechan fidel cell shape remodel high divid cell | D048430;D008938 | T043;T032 |
34,685,618 | new insight molecular mechan mediat adapt exercis review focus mitochondri biogenesi mitochondri function mitophagi autophagi exercis fundament good health practic regular confer myriad metabol benefit rang tissu benefit mediat rang adapt respons coordin multi organ manner continu understand molecular mechan action confer benefici effect exercis bodi identifi specif pathway manipul therapeut intervent order prevent treat various metabol associ diseas particular import exercis avail option novel method must identifi confer benefici effect exercis therapeut manner review focus key emerg molecular mechan mitochondri biogenesi autophagi mitophagi select high metabol tissu describ regul contribut benefici adapt exercis | D000222;D001343;D063306;D001678 | T040;T070;T043 |
34,685,617 | autophagi polar toward cell front migrat spatial perturb oncogen ras autophagi physiolog degrad process remov unnecessari dysfunct compon cell import normal cellular homeostasi respons varieti stress nutrient depriv defect autophagi link numer human diseas includ cancer cancer cell requir autophagi migrat invad studi intracellular topolog interplay autophagi cell migrat interdisciplinari live imag approach combin micro pattern techniqu autophagi report rfp gfp lc monitor time direct migrat back front spatial distribut lc posit compart autophagosom autolysosom moreov exploit genet control cell model assess impact transform ras oncogen one frequent mutat gene human cancer known increas cell motil basal autophagi static cell display isotrop distribut autophagi lc posit compart direct migrat global increas autophagi polar autophagosom autolysosom front nucleus migrat cell ras transform cell front polar lc compart much less organ spatial tempor compar normal cell might consequ alter lysosom posit conclus work reveal autophagi organell polar toward cell front migrat spatial tempor dynam alter motil cancer cell express oncogen ras protein | D001343;D002465;D011905;D009857 | T043;T028 |
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