PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,686,369 | hemoglobin multipl molecular interact multipl function exampl energi optim global molecular organ one might think year studi know know hemoglobin function howev purpos review outlin fascin protein still much say field biolog modul henc like focus number parallel function hemoglobin besid basic function oxygen transport among like recal follow main function modul erythrocyt metabol b heme oxid erythrocyt senesc c resist malaria molecular heat transduc e enzymat activ f hemorphin carbon monoxid nitric oxid | D006418;D006454 | T116;T109;T123 |
34,686,368 | one year clinic outcom patient small coronari arteri diseas treat drug elut stent observ studi indian popul percutan coronari intervent pci small vessel coronari arteri challeng due advers short term well long term outcom singl arm open label observ studi assess year clinic outcom drug elut stent des indian patient undergo pci symptomat small calibr coronari arteri diseas enrol indian patient small coronari arteri lesion refer vessel diamet mm elig implant mm des primari endpoint major advers cardiovascular event mace indic favour year clinic outcom des small coronari arteri lesion indian patient | D003324;D054855;D009203;D062645 | T074;T047;T061 |
34,686,365 | pharmacokinet safeti singl dose amphotericin b colloid dispers healthi chines subject popul pharmacokineticpharmacodynam analysi inform clinic efficaci invas infect caus candida albican amphotericin b colloid dispers abcd less toxic formul amphotericin b treatment invas fungal infect pharmacokinet pk profil safeti generic abcd investig singl dose mgkg administ intraven infus healthi chines subject | D000666;D002176 | T004;T195;T109 |
34,686,364 | continu renal replac therapi liber outcom critic ill patient acut kidney injuri examin associ continu renal replac therapi crrt liber clinic outcom among patient acut kidney injuri aki requir crrt | D058186;D000075902;D000079664;D007676;D020127 | T047;T184;T032;T061;T037 |
34,686,363 | supplement cancer screen women dens breast guidanc health care profession mammographi standard breast cancer screen sensit mammographi identifi breast cancer howev reduc women dens breast thirti eight state pass law requir women notifi breast tissu densiti result mammogram report notif includ statement differ state encourag women discuss supplement screen option health care profession hcps sever supplement screen test avail women dens breast tissu establish guidelin exist direct hcps recommend prefer supplement screen test tailor screen take consider patient mammograph breast densiti lifetim breast cancer risk guid breast cancer screen strategi comprehens review describ benefit limit various avail supplement screen test guid hcps patient choos appropri breast cancer screen | D001943;D055088 | T058;T191;T060 |
34,686,362 | suspect pneumonia caus coronavirus diseas kidney transplant case report coronavirus diseas covid infect may becom sever undergon kidney transplant general popul fals negat revers transcript polymeras chain reaction rt pcr result report covid infect patient might carri infect even though rt pcr result negat | D000086382;D016030 | T047;T061;T067 |
34,686,361 | factor associ reunif placement move children place kinship care age thirteen child need place substitut care child protect servic social worker encourag use kinship care kc main greater stabil associ howev current state knowledg reunif placement stabil essenti base studi combin children kc children type substitut care set | D002669;D005581 | T058;T056 |
34,686,360 | provid therapeut servic women children experienc intim partner violenc covid pandem challeng learn face covid pandem mani therapeut servic children parent experienc intim partner violenc ipv requir rapid transit telehealth | D000086382;D000066511 | T047;T053;T067 |
34,686,359 | trauma inform attitud residenti treatment set staff child youth factor predict adopt mainten chang time littl known benefit implement trauma inform care tic train program child welfar worker serv home treatment set staff child youth characterist affect adopt favor attitud toward tic | D006282;D012114 | T097;T061 |
34,686,357 | parkinson tremor syndrom tremor common movement disord may occur isol may co exist varieti neurolog movement disord includ parkinson dystonia ataxia associ parkinson diseas tremor may present rest action tremor overlap phenomenolog essenti tremor essenti tremor may associ parkinson neurolog disord suggest possibl essenti tremor subtyp besid parkinson diseas tremor import featur parkinsonian disord atyp parkinson drug induc parkinson addit tremor promin featur patient movement disord fragil x associ tremorataxia syndrom wilson diseas parkinsonian featur may present articl part special issu parkinson across spectrum movement disord beyond edit joseph jankov daniel truong matteo bologna | D020329;D020734 | T047;T050 |
34,686,356 | parkinson cerebrovascular diseas relationship cerebrovascular diseas parkinson common seen everyday clinic practic remain ill defin recognis littl guidanc practis neurologist attempt defin associ illustr key clinic radiolog patholog featur syndrom vascular parkinson vap vap major caus morbid elder associ fall hip fractur cognit impair although acut parkinson report context acut cerebrovascular event vast major vap present insidi syndrom usual context vascular risk factor radiolog evid small vessel diseas may anatom impact basal ganglia neuron network howev effect small vessel diseas svd pathway clear establish report standard radiolog featur svd mri white matter hyperintens lacun thought repres radiolog featur svd featur perivascular space gain import especi context glymphat system import consid vap differenti diagnosi parkinson diseas pd situat neuroimag may offer diagnost benefit especi patient atyp present refractori levodopa proactiv manag vascular risk factor monitor bone densiti exercis program may offer easili attain therapeut target pd vap levodopa therapi consid patient vap howev dose effect may differ use pd articl part special issu parkinson across spectrum movement disord beyond edit joseph jankov daniel truong matteo bologna | D059345;D002561;D060825;D010300;D020734 | T048;T047;T050 |
34,686,349 | adapt genom eros fragment pseudomona aeruginosa popul sinus peopl cystic fibrosi pseudomona aeruginosa notori adapt airway peopl cystic fibrosi cf yet infect site biogeographi associ evolutionari process vari lifelong infect progress remain unclear test hypothesi earli adapt promot aggreg influenc evolutionari genet trajectori examin longitudin p aeruginosa sinus six adult cf high host adapt lineag harbor mutat genotyp display signatur earli genom degrad associ recent host restrict use advanc imag techniqu mipact hcr microbi identif passiv clariti techniqu find popul structur track genom degrad host adapt genom degrad p aeruginosa mutat resid small spars aggreg propos follow initi adapt evolut larger popul strong select aggreg p aeruginosa persist small fragment popul experi stronger effect genet drift condit enrich mutat promot degen genom evolut find underscor import infect site biogeographi pathogen evolut | D019143;D016680;D009154 | T028;T038;T045 |
34,686,345 | neurotoxin subvert alloster activ mechan sarm induc neuron loss sarm induc tir domain nad hydrolas mediat patholog axon degener sarm activ increas ratio nmn nad compet bind alloster activ site nmn bind tir domain releas autoinhibit activ nad hydrolas activ discoveri alloster activ site led us hypothes nad relat metabolit might activ sarm show nicotinamid analog acetylpyridin ap first identifi neurotoxin convert apmn activ sarm induc sarm depend nad deplet axon degener neuron death mice system treatment ap caus rapid sarm depend death local applic peripher nerv induc sarm depend axon degener identifi aminopyridin anoth sarm depend neurotoxin find identifi sarm candid mediat environment neurotox suggest sarm agonist could develop select agent neurolyt therapi | D009410 | T049 |
34,686,344 | tau reduct affect excitatori inhibitori neuron differ reduc excitationinhibit ratio counteract network hypersynchroni protein tau implic mani brain disord anim model tau reduct suppress epileptogenesi divers caus amelior synapt behavior abnorm various condit associ excess excit inhibit ei ratio howev under mechan unknown global genet ablat tau mice reduc action potenti ap fire ei ratio pyramid cell acut cortic slice without affect excit cell tau ablat reduc excitatori input inhibitori neuron increas excit cell structur alter axon initi segment aiss primari neuron cultur subject prolong overstimul tau ablat diminish homeostat respons aiss inhibitori neuron promot inhibit suppress hypersynchroni togeth differenti alter excitatori inhibitori neuron help explain tau reduct prevent network hypersynchroni counteract brain disord caus abnorm increas ei ratio | D019706;D053444;D009433 | T042 |
34,686,341 | rnf mediat regul akt promot lung cancer cell surviv resist dna damag despit tremend success target convent therapi lung cancer therapeut resist common major clinic challeng rnf ubiquitin e ligas play essenti role dna damag respons howev role pathogenesi lung cancer unclear report rnf overexpress lung cancer posit correl express p akt poor surviv patient non small cell lung cancer addit identifi rnf e ligas regul activ akt k link ubiquitin physiolog genotox condit lead lung cancer cell prolifer resist chemotherapi togeth studi suggest rnf could promis target precis medicin lung cancer | D019008 | T042;T038 |
34,686,339 | trophectoderm cell failur lead peri implant lethal trpm defici mous embryo earli embryogenesi depend proper control intracellular homeostasi ion includ ca mg delet ca mg conduct trpm channel embryon lethal mice leav compact blastomer polar blastocoel format correct specif lineag trophectoderm inner cell mass unalt despit free cytoplasm ca mg reduc two cell stage although trpm embryo abl hatch zona pellucida expans trpm trophoblast cell observ trpm embryo identifi utero e later given prolifer adhes defect trpm trophoblast stem cell abil trpm esc develop embryo tetraploid embryo complement assay postul critic role trpm trophectoderm cell failur implant like explan development arrest trpm defici mous embryo | D002448;D049109 | T043 |
34,686,338 | defici er ca sensor stim agrp neuron confer protect dietari obes store oper calcium entri soce pivot maintain intracellular ca level cell function howev role obes develop remain larg unknown show stromal interact molecul stim endoplasm reticulum er ca sensor soce critic involv obes develop pharmacolog blockad soce brain disrupt stim hypothalam agouti relat peptid agrp produc neuron asko signific amelior dietari obes associ metabol disord convers constitut activ stim agrp neuron lead obes like phenotyp show blockad soce suppress general translat neuron cell via oligoadenyl synthetas oa rnase l signal oa overexpress agrp neuron protect mice dietari obes deactiv rnase l neuron signific abolish effect asko find highlight import role stim soce develop obes | D020013 | T043 |
34,686,337 | crim kelch like exert complementari dual direct development control segment specif corticospin axon project target cerebr cortex execut high skill movement necessit connect accur specif brainstem spinal motor circuitri corticospin neuron csn must correct target specif spinal segment basi target remain unknown accompani report show segment distinct csn subpopul molecular distinct earli develop identifi candid molecular control segment specif axon target function investig two candid molecular control crim kelch like klhl identifi critic role direct csn axon appropri spinal segment level white matter prior axon collater crim klhl specif express distinct csn subpopul regul different white matter project target crim direct thoracolumbar axon extens klhl limit axon extens bulbar cervic segment molecular regul descend spinal project constitut first stage dual direct set complementari control csn divers segment function distinct circuitri | D000071446 | T040 |
34,686,336 | effici stimul retin regener mller glia adult mice use combin proneur bhlh transcript factor regen neurosci aim stimul endogen repair nervous system replac neuron lost degen diseas recent report overexpress transcript factor ascl mller glia mg suffici stimul mg regener function neuron adult mous retina howev process ineffici third ascl express mg generat new neuron test whether proneur transcript factor atoh class promot regen capac mg find combin ascl atoh remark effici stimul neurogenesi even absenc retin injuri use electrophysiolog singl cell rna sequenc scrna seq demonstr ascl atoh generat divers retin neuron type major express characterist retin ganglion cell result provid proof principl combin development transcript factor substanti improv glial reprogram neuron expand repertoir regener cell fate | D009416;D055495 | T043;T042;T040 |
34,686,335 | marker free lineag trace reveal environ instruct clonogen hierarchi pancreat cancer effect treatment pancreat ductal adenocarcinoma pdac lack target agent demonstr limit efficaci specul rare popul cancer stem cell cscs drive growth therapi resist rapid metastat progress pdac cscs demonstr high clonogen vitro tumorigen potenti vivo howev relev establish pdac tissu determin use marker independ stochast clonal label combin quantit model tumor expans uncov pdac tissu growth dynam find contrast csc model pdac cell display clonogen potenti situ furthermor proxim activ cancer associ fibroblast determin tumor cell clonogen mean microenviron domin defin clonogen activ pdac cell inde manipul stroma hedgehog pathway inhibit alter tumor growth mode reveal tumor stroma crosstalk shape tumor growth dynam clonal architectur | D019070;D059016 | T070;T078 |
34,686,334 | p mediat cell growth surviv drive rapid embryon wound repair embryo repair wound rapid inflamm scar process involv polar actomyosin cytoskeleton actomyosin polar result assembl contractil cabl around wound drive wound closur demonstr contractil actomyosin cabl suffici rapid wound repair drosophila embryo show wound caus activ serinethreonin kinas p mitogen activ protein kinas mapk cell adjac wound p activ reduc level wound induc reactiv oxygen speci cell around wound limit wound size addit p promot increas volum cell around wound thus facilit collect cell movement drive rapid wound heal data indic p regul cell volum sodium potassium chlorid cotransport nkcc work reveal cell growth cell surviv cell behavior critic embryon wound repair | D049109;D014945 | T043;T040 |
34,686,333 | ror ryk extracellular region structur suggest receptor tyrosin kinas distinct wnt recognit mode wnts play key role develop diseas signal frizzl fzd seven pass transmembran receptor numer co receptor includ ror ryk famili receptor tyrosin kinas rtks describ crystal structur wnt bind characterist extracellular region drosophila ror ryk ortholog nrk neurospecif receptor tyrosin kinas derail drl bind wnts though fzd relat cystein rich domain crd wnt inhibitori factor wif domain respect crystal structur suggest neither nrk drl accommod acyl chain typic attach wnts nrk crd contain deepli buri bound fatti acid unlik exchang drl wif domain lack lipid bind site seen wif also find recombin dwnt bind drosophila ror ryk ortholog despit lack acyl chain alongsid analys wntreceptor interact site structur provid insight wnts may recruit rtk co receptor signal complex | D060449 | T044 |
34,686,332 | derlin rhomboid pseudoproteas employ substrat engag lipid distort enabl retrotransloc erad membran substrat near one third protein initi target endoplasm reticulum er membran correct fold deliv final cellular destin prevent accumul misfold membran protein er associ degrad erad move client er membran cytosol process known retrotransloc recent work saccharomyc cerevisia reveal derlin rhomboid pseudoproteas dfm involv retrotransloc ubiquitin erad membran substrat studi identifi conserv residu dfm critic retrotransloc find sever retrotransloc defici loop mutant display impair bind membran substrat furthermor dfm possess lipid thin function facilit remov er membran substrat featur conserv human homolog derlin implic derlin mediat retrotransloc well conserv process | D060746;D050356 | T044 |
34,686,331 | direct indirect pathway neuron ventrolater striatum differenti regul lick movement nigral respons drink behavior rodent character stereotyp rhythmic lick movement regul basal ganglia unclear direct indirect pathway control lick bout individu spout contact find inactiv receptor express medium spini neuron msns ventrolater striatum vls opposit alter number lick bout msns exhibit differ pattern lick sequenc relat activ differ phase oscil time lock lick cycl timescal lick cycl transient inactiv msns tongu protrus reduc spout contact probabl wherea transient inactiv msns effect timescal lick bout inactiv msns msns caus rate increas decreas subset basal ganglia output neuron decreas fire lick result reveal distinct role msns regul lick coars fine timescal | D001522;D004327 | T053;T055 |
34,686,327 | pan cancer analysi non code transcript reveal prognost onco lncrna hoxa glioma long non code rnas lncrnas increas recogn function unit cancer power biomark howev remain uncharacter analyz prognost lncrnas cancer type use machin learn identifi lncrnas whose express correl surviv improv accuraci common clinic variabl molecular featur cancer subtyp prognost lncrnas often character switch like express pattern low grade glioma hoxa activ robust marker poor prognosi complement idh mutat valid anoth retrospect cohort correl development pathway tumor transcriptom loss gain function studi patient deriv glioma cell organoid xenograft model identifi hoxa potent onco lncrna regul cell prolifer contact inhibit invas hippo signal mitot neuro development pathway studi underscor pan cancer potenti non code transcriptom identifi biomark regul cancer progress | D020869;D059467 | T086;T059;T063;T081 |
34,686,326 | multist stem cell dynam maintain homeostasi mous spermatogenesi mous testi heterogen popul undifferenti spermatogonia undiff harbor spermatogen stem cell ssc potenti although gfr undiff maintain self renew pool homeostasi function basi heterogen implic dynam remain unresolv quantit lineag trace ssc subpopul show ensembl heterogen state sscs support homeostat persist spermatogenesi heterogen maintain robust stochast interconvers sscs renew bias plvap gfr state differenti prime sox gfr state framework stem cell commit occur direct gradual entri licens uncommit state plvap gfr cell divid slowli synchroni seminifer epitheli cycl sox gfr cell divid much faster differenti cell cycl dynam reduc mitot load therebi potenti acquir harm de novo mutat self renew pool keep ssc densiti high testicular open nich | D019070;D013091 | T043;T078 |
34,686,325 | nkga express identifi subset human v cell exert highest antitumor effector function human v cell innat like effector perform potent immun surveil tumor constitut express nkga identifi subset v cell licens intrins hyper respons cancer inde transcriptom profil nkga nkga cell character two distinct intralineag v lymphocyt appear earli develop keep phenotyp show self renew capabl adult life hyper respons nkga v cell counterbalanc inhibitori signal deliv human leukocyt antigen e hla e express malign cell tumor escap mechan howev either mask knock nkga restor capac v cell exert highest effector function even hla e tumor high relev clinic differ degre engag nkga hla e checkpoint hepatocellular carcinoma glioblastoma non small cell lung cancer direct impact patient overal surviv find open avenu develop combin cellular immunolog anticanc therapi | D003602;D008213 | T043 |
34,686,324 | monitor mitochondri calcium metabol beat mcu ko heart optic method measur intracellular ion includ ca revolution understand signal transduct howev method extens appli intact organ due issu includ inner filter effect motion avail probe mitochondri ca postul regul cell energet death pathway best studi intact organ develop method optic measur mitochondri ca demonstr valid mitochondri ca metabol use heart wild type mice mice germlin knockout mitochondria calcium uniport mcu ko previous report germlin mcu ko heart show impair respons adrenerg stimul find mcu ko heart take ca consist altern ca uptak mechan absenc mcu approach address role mitochondri ca myriad function attribut alter mitochondri ca | D020013;D004734;D009200 | T043;T039;T042;T040 |
34,686,323 | pupil enabl map stamp transient electr connect develop nervous system current mani genet method avail map chemic connect analog method electr synaps lack present pupyl base interact label pupil genet encod system noninvas map stamp transient electr synaps mous brain upon fusion connexin cx ligas pafa pupyl yield tag puncta follow conjug substrat biotin fluoresc protein tag pupe neighbor protein electr synaps contain cx pafa tag puncta valid correl well function electr synaps immatur neuron furthermor puncta retain matur neuron electr synaps most disappear suggest success stamp use pupil uncov spatial subcellular local electr synaps approach physiolog function develop thus pupil power tool probe electr connect pattern complex nervous system great potenti transient receptor ion channel well | D062308 | T063 |
34,686,322 | parkinson diseas associ mutat lrrk gs alter dopaminerg differenti dynam via nrf increas evid suggest neurodevelopment alter might contribut increas suscept develop neurodegen diseas investig occurr development abnorm dopaminerg neuron model parkinson diseas pd monitor differenti human patient specif neuroepitheli stem cell nesc dopaminerg neuron use high throughput imag analys singl cell rna sequenc observ pd associ lrrk gs mutat alter initi phase neuron differenti acceler cell cycl exit concomit increas cell death identifi nesc specif core regulatori circuit molecular mechan under observ phenotyp express nrf key transcript factor involv neurogenesi decreas lrrk gs nesc neuron midbrain organoid compar control also observ acceler dopaminerg differenti vivo nrf defici mous embryo suggest pathogen mechan involv lrrk gs mutat dynam dopaminerg differenti modifi via nrf | D055495 | T040 |
34,686,321 | proteom phosphoproteom analys identifi liver relat signal retin pigment epitheli cell emt epitheli mesenchym transit emt retin pigment epithelium rpe associ sever blind retin diseas use proteom phosphoproteom studi human induc pluripot stem cell deriv rpe monolay induc emt captur kinasephosphatas signal cascad h h induct better understand pathway mediat rpe emt induct co treatment transform growth factor tumor necrosi factor alpha tgnf enzymat dissoci perturb signal mani pathway strike similar respect phosphoproteom h liver hyperplasia hepatocyt growth factor hgf met signal exhibit highest overal enrich also observ hgf epiderm growth factor signal two cooper pathway inhibit emt induct regul rpe transcript profil | D058750;D020543;D040901 | T043;T091;T116;T123 |
34,686,320 | corticospin neuron subpopul specif development gene prospect indic matur segment specif axon project target precis motor control distinct subpopul corticospin neuron csn must extend axon distinct spinal segment proxim target brainstem cervic cord distal target thorac lumbar spinal segment find develop csn subpopul exhibit strike axon target specif spinal white matter establish foundat durabl specif adult corticospin circuitri employ development retrograd anterograd label distinct neocort locat purifi develop csn subpopul use fluoresc activ cell sort identifi gene differenti express bulbar cervic thoracolumbar project csn subpopul critic development time segment distinct csn subpopul molecular distinct earliest stage axon extens enabl prospect identif even eventu axon target decis evid spinal cord molecular delin extend beyond simpl spatial separ subpopul cortex togeth result identifi candid molecular control segment specif corticospin axon project target | D018507;D000071446 | T040;T045 |
34,686,319 | post oral sens fat increas food intak attenu bodi weight defens mammal chang weight elicit respons favor return one previous weight promot weight stabil hypothes palat sweet high fat food disturb defens bodi weight lead weight gain find increas sweet percent calori fat increas diet palat increas nutrit fat content increas calor intak bodi weight mous model overfeed activ weight defens high fat diet sweeten diet attenu defens bodi weight lead weight gain abil palat high fat diet increas food intak requir tast smell food instead direct infus high fat diet stomach increas ad libitum intak less palat low fat food post oral sens percent calori fat modul feed behavior alter weight stabil | D004435;D002149;D005247;D013649;D015430 | T055;T042;T081;T040;T033;T038 |
34,686,318 | medic student learn process first time role play psychiatri ground theori studi recent chang psychiatr care teach limit patient contact medic student overcom part simul base educ understand learn process medic student involv psychiatr simul base programm could use inform effort improv teach studi explor learn process medic student first time role play psychiatri | D004501;D011570;D013337 | T097;T065;T091 |
34,686,316 | simpl oligonucleotid base multiplex singl cell chromatin access microdroplet singl cell atac seq wide use measur chromatin access howev high scalabl simpl sampl multiplex procedur avail present transposom assist singl nucleus barcod approach atac seq snubar atac util singl oligonucleotid adaptor multiplex sampl exist tagment step requir pre label procedur accuraci scalabl snubar atac evalu use cell line mixtur experi appli snubar atac investig treatment induc chromatin access dynam multiplex mice lung tumor receiv differ combin chemo radiat target immunotherapi also appli snubar atac studi spatial epigenet heterogen multiplex region human breast tissu addit show snubar multiplex singl cell atac rna multiom assay cell line human breast tissu sampl data show snubar high accur easi use scalabl system multiplex scatac seq scatac rna co assay experi | D042002;D044127;D015972;D018740;D059010 | T032;T059;T045 |
34,686,315 | aberr rna methyl trigger recruit alkyl repair complex central genotox respons abil sens high specif signal activ appropri repair respons previous report activ ascc alkbh repair pathway exquisit specif alkyl damag human cell yet mechanist basi select pathway immedi obvious demonstr rna dna alkyl initi signal process aberr methyl rna suffici recruit ascc rna dealkylas suppress ascc recruit chemic alkyl turn recruit ascc alkyl damag mediat e ubiquitin ligas rnfa suppress transcript r loop format show alkyl pre mrna suffici activ rnfa e ligas vitro manner depend rna bind zn finger domain togeth work identifi unexpect role rna damag elicit specif respons genotoxin | D012323 | T045 |
34,686,314 | adapt translat paus hallmark cellular respons sever environment stress surviv mammalian cell must adapt environment challeng cellular respons mild stress wide studi cell respond sever stress remain unclear show sever hyperosmot stress cell enter transient hibern like state anticip recoveri demonstr adapt paus respons apr coordin cellular respons limit atp suppli consumpt mitochondri fragment widespread paus mrna translat paus accomplish ribosom stall translat initi codon keep mrnas pois resum translat upon recoveri show recoveri sever stress involv isr integr stress respons signal permit cell cycl progress resumpt growth revers mitochondria fragment find indic cell respond sever stress via hibern like mechan preserv vital element cellular function harsh environment condit | D049109;D009997;D014176 | T043;T070;T044 |
34,686,313 | new way deal protein misfold huang et al show protein contain aspart glutam rich stretch repres putat new class atp independ molecular chaperon oper divers client protein vitro protect bona fide interactor aggreg cell | D018832 | T116;T123 |
34,686,312 | expand regul circular rna translat chen et al identifi mani intern ribosom entri site like element potenti drive circrna translat dozen element contain circrna encod peptid valid among circfgfr encod protein act antagonist fgfr | D000067556;D000079962 | T086;T114 |
34,686,311 | interferon induct held captiv tumor cell unusu nucleic acid activ innat immun may present transform cell meng et al find cancer associ mutat nf turn tumor suppressor potent antagonist dna rna induc innat immun signal | D007372;D009696 | T129;T116;T114;T123 |
34,686,307 | stent thrombosi battl data franc pci registri aim studi assess incid risk factor prognosi definit stent thrombosi st year franc pci multicent prospect registri | D054058;D003328;D062645;D013927 | T047;T061;T046 |
34,686,303 | risk pattern mortal postmenopaus women use latent class analysi although risk factor often co occur previous studi examin lifestyl psychosoci factor often treat factor individu predictor health studi aim identifi under subgroup women character distinct lifestyl psychosoci risk pattern investig prospect associ risk pattern mortal among postmenopaus women | D008019;D017698 | T040;T047;T054 |
34,686,302 | associ membership medic fit facil advers health outcom intervent increas physic activ behavior reduc morbid prolong life long term effect larg popul unproven studi investig associ medic fit facil membership frequenc attend caus mortal rate hospit | D015444;D006760 | T058;T061;T056 |
34,686,301 | long act revers contracept condom use sexual transmit infect systemat review meta analysi given mix find regard relationship long act revers contracept condom use systemat review meta analysi synthes studi compar sexual transmit infectionrel outcom user long act revers contracept intrauterin devic implant user moder effect contracept method oral contracept inject patch ring | D000075523;D012749 | T047;T061 |
34,686,300 | sugar sweeten beverag consumpt children interplay household snap wic particip although sugar sweeten beverag ssb consumpt associ supplement nutrit assist program snap special supplement nutrit program women infant children wic particip nation studi examin interplay program studi compar children sugar sweeten beverag consumpt across household enrol one neither program | D063105;D000080845 | T057;T168;T064 |
34,686,299 | impact prison therapeut divers unit mental behavior health outcom incarcer individu mental health disord disproport sent restrict hous ie solitari confin known deleteri impact mental health respons north carolina prison system develop therapeut divers unit treatment orient unit incarcer individu high mental health need cycl restrict hous analysi compar impact restrict hous therapeut divers unit infract mental health self harm among incarcer individu | D001523;D011329 | T048;T098 |
34,686,296 | public health detail promot hiv pre postexposur prophylaxi among women healthcar provid new york citi equit access hiv pre postexposur prophylaxi women essenti end hiv epidem provid lack knowledg comfort discuss prescrib pre exposur prophylaxi women persist barrier | D019380;D015658;D065129 | T047;T121;T061 |
34,686,295 | academ detail increas prescrib hiv pre exposur prophylaxi although hiv pre exposur prophylaxi decreas new case hiv mani patient could benefit pre exposur prophylaxi never receiv prescript pre exposur prophylaxi indic patient infecti diseas increas pre exposur prophylaxi prescrib primari care generalist clinician repres key element end hiv epidem us initi review provid overview academ detail current use increas pre exposur prophylaxi prescrib academ detail outreach educ engag clinician small group interact focus identifi address individu clinician need increas use evid base practic academ detail proven multipl previous research studi principl requir success implement includ interact clinic relev content focus defin behavior chang object clinician barrier pre exposur prophylaxi prescrib may occur domain knowledg attitud behavior academ detail potenti address area state local health depart develop academ detail program focus pre exposur prophylaxi prescrib element hiv prevent sometim describ approach public health detail studi academ detail pre exposur prophylaxi publish date rigor evalu hiv specif adapt innov approach would repres import contribut set covid pandem interest virtual deliveri academ detail grown could inform effort implement academ detail rural communiti underserv area increas capac could make import contribut end hiv epidem us hiv prevent effort | D000086382;D015658;D065129 | T047;T061;T067 |
34,686,294 | pre exposur prophylaxi uptak adher persist narrat review intervent us sinc hiv pre exposur prophylaxi prep avail prevent hiv transmiss yet uptak adher persist prep suboptim narrat review examin latest intervent program improv stage prep adher review ongo studi promot effect prep use total studi analyz differ individu structur level approach increas prep adher includ behavior chang intervent technolog base intervent eg short messag servic messag mobil applic altern deliveri strategi eg pharmaci base prep integr servic home deliveri publish intervent involv men sex men although assess women transgend cisgend random control data support behavior chang intervent technolog base intervent altern deliveri strategi seem promis although robust studi design general need addit data align ongo hiv risk prep persist ie prevent effect adher limit author also identifi ongo studi promot prep adher futur work inclus risk group us includ african american latinx heterosexu popul peopl inject drug proven promis approach may work well combin may also need adapt introduct long act pre exposur prophylaxi formul collect bodi work indic consider progress toward understand role prep adher play end hiv epidem us bolster outcom ongo trial | D019380;D015658;D065129;D000072339 | T098;T047;T121;T061 |
34,686,293 | toward greater pre exposur prophylaxi equiti increas provis uptak black hispaniclatino individu us pre exposur prophylaxi prep high effect prevent hiv acquisit critic tool end hiv epidem us initi howev major racial ethnic dispar across pre exposur prophylaxi continuum secondari structur inequ system racism threaten progress mani barrier oper individu network healthcar structur level imped prep access uptak within black hispaniclatino communiti review provid overview barrier innov collabor solut health depart healthcar organ communiti partner implement increas prep provis uptak among disproportion affect communiti promis strategi individu network level focus increas patient support throughout prep continuum posit train communiti member expand knowledg interest prep leverag mobil technolog support prep uptak healthcar level solut includ expand venu type healthcar profession provid prep structur polici level option focus financi assist program health insur expans key research gap includ demonstr pilot studi intervent remain effect scale across vari context although last decad provid effect tool end hiv epidem realiz vision us requir address persist pervas hiv relat dispar black hispaniclatino communiti feder state local partner expand effort address longstand health structur inequ partner disproportion affect communiti rapid expand prep scale | D019380;D015658;D065129 | T047;T121;T061 |
34,686,292 | hiv test strategi health depart end epidem us import goal end hiv epidem us initi time diagnosi peopl hiv earli possibl infect end hiv epidem health depart encourag propos new innov hiv test strategi improv reach exist program activ divid core strategi expans routin screen healthcar set local tailor hiv test initi nonhealthcar set specif effort increas frequenc test individu increas potenti acquir hiv hiv test crucial part core activ center diseas control prevent hiv prevent program mani exampl evid base program best practic hiv test clinic nonclin set articl review evid base strategi activ propos diagnos pillar achiev goal diagnos hiv infect earli possibl end hiv epidem us activ start awar hiv status actual indic health depart closest propos target proven emerg approach increas hiv screen increas frequenc hiv screen avail end hiv epidem us initi provid motiv resourc coordin plan bring scale | D058872;D015658 | T047;T067 |
34,686,291 | georgia leverag telehealth expand hiv care manag underserv area southeast us georgia particular disproport affect hiv major barrier georgia meet goal end hiv epidem us lack proxim hiv care address barrier georgia implement comprehens hiv telehealth system includ telemedicin provid remot care client local medic home addit telementor program project extens communiti healthcar outcom initi strengthen hiv provid workforc georgia | D000086382;D015658;D017216 | T058;T047;T067 |
34,686,290 | develop citywid rapid antiretrovir therapi initi san francisco end hiv epidem us hold rapid antiretrovir therapi key strategi improv health hiv decreas transmiss get zero san francisco multisector consortium expand rapid antiretrovir therapi citywid | D019380;D015658 | T047;T121 |
34,686,289 | hiv treat pillar updat summari promis approach treat pillar end hiv epidem us plan call comprehens strategi enhanc linkag engag hiv medic care improv viral suppress among peopl hiv achiev goal viral suppress us seen larg increas proport peopl hiv suppress viral load viral suppress increas addit increas need meet end hiv epidem us goal rate viral suppress among care increas highlight need ensur sustain care peopl hiv greater increas step along hiv care continuum need disproportion impact hiv especi young sexual racialethn minor peopl experienc homeless peopl inject drug inform systemat review current research find paper describ recent promis practic suggest impact hiv care outcom highlight rapid linkag treatment intervent intervent identifi engag peopl hiv care new collabor among health depart provid hospit system coordin care low barrier clinic model telemedicin deliv hiv care approach intervent present paper provid addit approach state local jurisdict use reach local hiv elimin plan goal ambiti end hiv epidem us treat pillar target | D015658 | T047 |
34,686,288 | cost consequ elimin routin point care hiv screen program high preval jail studi aim assess public health impact elimin longstand routin hiv screen program replac target test addit cost outcom cost effect routin screen compar target test fulton counti jail atlanta georgia | D015658 | T047 |
34,686,287 | communiti health worker approach end hiv epidem second half east baton roug parish louisiana select jump start pilot jurisdict center diseas control prevent fund end hiv epidem us initi innov communiti health worker program among strategi develop reduc number new hiv infect addit test hivsexu transmit infect nontradit set communiti health worker provid integr servic includ linkag peopl hiv pre exposur prophylaxi navig steril inject suppli referr syring servic program social servic | D058872;D015658;D065129;D012749 | T047;T061;T067 |
34,686,286 | detect respons hiv cluster peopl live homeless use drug seattl washington hiv epidem king counti washington tradit high concentr among men sex men incid gradual declin decad king counti experienc geograph concentr outbreak hiv among heterosexu peopl inject drug | D015658;D004364;D000072339;D015819 | T048;T047;T121;T098 |
34,686,285 | pilot mail hiv sexual transmit infect test washington district columbia covid pandem district columbia record year low rate new hiv infect also near record number gonorrhea chlamydia infect district columbia depart health support numer form communiti base person screen direct home test | D000086382;D002690;D006069;D015658;D000072339;D012749 | T047;T098;T067 |
34,686,284 | interdisciplinari hiv sentinel case review identifi practic prevent outbreak philadelphia end hiv epidem us initi consid cluster outbreak respons essenti articl describ design implement earli find philadelphia base project systemat assess sentinel case among prioriti popul improv public health infrastructur prevent futur outbreak | D015658;D000072339 | T047;T098 |
34,686,283 | respons larg hiv outbreak cabel counti west virginia januari west virginia bureau public health detect increas hiv diagnos among peopl inject drug cabel counti respond hiv cluster outbreak pillar end hiv epidem us initi requir activ diagnos treat prevent pillar articl describ design implement comprehens respons featur intervent pillar | D015658;D015819 | T048;T047 |
34,686,282 | hiv cluster outbreak detect respons scienc experi respond pillar end hiv epidem us initi consist activ also known cluster outbreak detect respons offer framework guid tailor implement proven hiv prevent strategi transmiss occur rapid cluster outbreak respons involv understand network rapid transmiss occur link peopl network essenti servic identifi address gap program servic test hiv medic care pre exposur prophylaxi syring servic program articl review experi gain hiv cluster outbreak respons north america describ approach implement core respons strategi numer jurisdict implement respons strategi demonstr success improv outcom relat hiv care viral suppress test use prevent servic reduct transmiss new diagnos effort address import gap servic deliveri reveal cluster outbreak detect respons strengthen prevent effort broad multidisciplinari multisector collabor way respond pillar embodi collabor data guid approach critic overal success end hiv epidem us initi | D015658;D065129 | T047;T061 |
34,686,281 | syring servic program role end hiv epidem us without diagnos hiv among peopl inject drug increas us first time decad multipl hiv outbreak detect among peopl inject drug sinc epidemiolog trend pose signific concern achiev goal feder initi end hiv epidem us syring servic program cost effect safe high effect reduc hiv transmiss essenti compon comprehens integr approach address concern yet geograph coverag program remain limit us mani jurisdict continu law polici limit disallow syring servic program depth literatur review conduct role syring servic program end hiv epidem initi empir model base evid consist show syring servic program highest impact hiv prevent combin access medic substanc use disord antiretrovir therapi effect maxim provid servic without restrict includ proven innov strategi expand access harm reduct clinic servic eg peer outreach telehealth increas geograph servic coverag syring servic program requir strong sustain polici fund communiti support need address new challeng relat covid pandem syring servic program key role end hiv epidem initi strategi prevent diagnos treat respond thus instrument success prevent diseas save live | D000086382;D015658;D015819 | T048;T047;T067 |
34,686,280 | bring iowa teleprep scale qualit evalu region partnership public health organ telehealth program potenti expand access hiv pre exposur prophylaxi rural small urban area howev littl known best practic partnership iowa teleprep region public healthpartn telehealth model creat iowa depart public health univers iowa expand statewid qualit evalu assess barrier facilit statewid expans lesson learn | D000086382;D065129 | T047;T061;T067 |
34,686,278 | sever spontan atherosclerosi two korat breed cat compar human atherosclerosi atherosclerosi chronic inflammatori vascular diseas lead caus mortal human worldwid domest anim speci howev primari atherosclerosi littl clinic relev cat consid atheroresist knowledg spontan atherosclerosi report cat report clinic histopatholog find two relat cat korat breed present clinic sign heart failur case clinic sign appear adulthood progress led death necropsi sever atherosclerot lesion present larg medium size arteri character format fibrous cap lipid core contain particular larg accumul cholesterol crystal indic presenc mani cholesterol cleft lesion close resembl advanc human atherosclerosi under diseas medic treatment could predispos atherosclerosi two genet relat cat genet predisposit human like atherosclerosi local korat cat popul suspect | D050197;D002371 | T047;T046 |
34,686,277 | distribut pseudorabi virus antigen hunt dog concurr paragonimus westermani infect follow isol pseudorabi virus prv two hunt dog oita prefectur japan investig prv antigen distribut tissu infect anim necropsi prv associ lesion includ facial oedema tonsillar mening congest blotchi haemorrhag pericardium mitral valv incomplet splenic contract one dog less promin find dog multipl pulmonari nodul seen case caus diploid form paragonimus westermani lung fluke confirm pcr restrict fragment length polymorph gene sequenc analys histolog examin reveal prv infect associ lesion non suppur enceph brainstem prv antigen detect cerebrum cerebellum brainstem submucos myenter plexus mononuclear cell main bone marrow lymph node tonsil spleen tissu evid prv dissemin brain via trigemin olfactori rout addit possibl spread lymphoid organ via infect mononuclear cell | D004283;D011558;D010237 | T047;T005 |
34,686,276 | addit valu second harmon generat microscopi diagnosi felin collagen type iii glomerulopathi year old neuter femal domest shorthair cat euthan diagnosi end stage protein lose nephropathi associ onset nephrot syndrom necropsi kidney diffus pale swollen granular cortex histolog glomeruli diffus global mesangi capillari wall expans homogen pale eosinophil materi materi congo red negat blue masson trichrom stain weak posit period acid schiff stain bright red picrosirius red birefring polar light transmiss electron microscopi second harmon generat shg microscopi reveal mesangi subendotheli collagen fibril deposit type iii collagen deposit confirm immunohistochemistri studi provid origin complet descript felin collagen type iii glomerulopathi emphas possibl direct diagnos glomerular collagen deposit unstain slide shg microscopi | D002371;D007674;D000073798 | T047;T059 |
34,686,275 | spontan dissemin histiocyt sarcoma bengal tiger panthera tigri tigri year old femal captiv bengal tiger panthera tigri tigri histori recurr subcutan mass two attempt surgic remov euthanasia elect third surgic attempt due degre neoplast infiltr necropsi larg subcutan mass infiltr dermi subcuti abdomin wall metastasi lung spleen adren gland microscop neoplasm form nodul compris sheet round cell larg irregular nuclei toluidin blue giemsa stain negat immunohistochemistri panel reveal membran cytoplasm label ioniz calcium bind adaptor molecul iba cytoplasm label vimentin label multipl myeloma oncogen mum cd pancytokeratin marker base gross distribut histolog immunohistochemistri featur diagnosi dissemin histiocyt sarcoma made best knowledg first record dissemin histiocyt sarcoma captiv bengal tiger | D054747;D046010 | T191;T015 |
34,686,274 | malign perivascular epithelioid cell tumour savannah monitor varanus exanthematicus year old male captiv savannah monitor varanus exanthematicus histori general debil submit necropsi grossli multipl white mass colon mesorchium tracheal adventitia histolog lesion compos epithelioid spindloid neoplast cell arrang sheet interlac interwoven bundl separ abund myxoid materi extens stromal hyalin fibrosi occasion chondroid metaplasia perivascular infiltr epithelioid neoplast cell occasion seen neoplast cell immunoposit alpha smooth muscl actin melan uniqu histolog featur concurr myogen melanocyt immunophenotyp suggest malign perivascular epithelioid cell tumour knowledg first report perivascular epithelioid cell tumour non human speci | D008116;D054973;D012509 | T191;T014 |
34,686,273 | subleukaem lymphoblast leukaemia hors year old dutch warmblood geld refer clinic sign anorexia weight loss intermitt fever cough subcutan oedema exercis intoler haematolog examin reveal presenc blast cell decreas lymphocyt mild thrombocytopenia anaemia leucocytosi serum analys detect elev aspart aminotransferas gamma glutamyl transferas activ triglycerid concentr twenti two day initi visit hors die show clinic sign decreas appetit increas bodi temperatur tachypnoea tachycardia necropsi mild splenomegali enlarg lymph node mass nodul seen organ histolog neoplast cell seen subcapsular medullari lymph sinus mediastin axillari mesenter renal lymph node bone marrow dens cellular numer larg round neoplast cell round nuclei clear nucleoli scant cytoplasm neoplast cell immunoposit cd negat cd bla cd iba cd granzym b base find neoplasm diagnos subleukaem lymphoblast leukaemia best knowledg first report neoplasm hors | D006734;D054198 | T191;T047 |
34,686,272 | mycoplasma bovi may travel along eustachian tube caus mening japanes black cattl mycoplasma bovi bovi common inhabit upper lower respiratori tract cattl consid main aetiolog agent otiti media calv eustachian tube appear common portal pathogen enter middl ear investig transmiss rout bovi caus otiti media progress mening meningoenceph japanes black cattl bovi detect case loop mediat isotherm amplif method immunohistochemistri one case caseonecrot granulomat meningoenceph one case caseonecrot granulomat mening one case suppur meningoenceph eight case eustach nine case tonsil six case suppur bronchopneumonia identifi histopatholog examin bovi antigen detect eustachian tube eight case nine case bovi also detect tonsillar epitheli crypt lumina intralumin inflammatori cell epitheli cell minor salivari gland locat around eustachian tube tonsil result suggest bovi infect colon tonsil enter eustachian tube caus otiti media case chronic infect progress mening | D002418;D005064;D008581;D045682 | T023;T047;T007 |
34,686,271 | canin non angiogen non myogen splenic stromal sarcoma retrospect clinicopatholog analysi investig podoplanin marker tumour histogenesi splenic stromal sarcoma rare report tumour previous group non angiomat non lymphomat mesenchym neoplasm canin spleen high variabl surviv time report probabl due heterogen natur purpos studi assess outcom prognost factor dog splenic stromal sarcoma treatment splenectomi clinic data collect retrospect histopatholog review patient histolog classif base morpholog haematoxylin eosin stain section conjunct immunolabel macrophag scaveng receptor cd desmin factor viii relat antigen smooth muscl actin yield diagnos undifferenti stromal sarcoma n complex nodular hyperplasia cnh n sarcoma aris benign complex nodular hyperplasia n histiocyt sarcoma n haemangiosarcoma n leiomyosarcoma n four sampl exclud analysi due extens necrosi anti podoplanin pdpn antibodi valid canin tissu use assess express protein potenti indic tissu origin neoplasm tumour posit statist signific differ surviv time patient stromal sarcoma sarcoma benign cnh undifferenti stromal sarcoma cnh versus respect p dog stromal sarcoma high mitot count per high power field signific shorter surviv time versus p clinic diagnosi splenic tumour includ evalu presenc benign nodular hyperplasia morpholog immunohistochemistri exclud aggress malign adjuv therapi recommend human pdpn may effect marker stromal sarcoma canin spleen immunoposit suggest fibroblast reticular follicular dendrit cell origin | D004283;D054747;D012509;D013160 | T191;T047 |
34,686,269 | raynaud phenomenon vasospast disord vasospast disord preval general popul affect individu age primari idiopath vasospast disord often benign cours treatment focus control symptom secondari vasospast disord occur owe under condit increas risk complic includ tissu loss digit ulcer treatment focus under condit review discuss pathophysiolog clinic present diagnosi manag vasospast disord includ raynaud syndrom acrocyanosi livedo reticulari pernio | D011928 | T047 |
34,686,268 | varicos vein chronic venous diseas chronic venous diseas worldwid problem associ signific morbid expect increas preval current popul age comprehens review anatomi pathophysiolog genom clinic classif treatment modal chronic venous diseas | D014648;D014689 | T047 |
34,686,267 | venous thromboembol practic cardiologist venous thromboembol vte encompass pulmonari embol pe deep vein thrombosi dvt encount common acut pe may present high risk cardiovascular emerg acut dvt caus acut chronic vascular complic goal review ensur cardiologist comfort manag vte includ risk stratif anticoagul therapi familiar primari reperfus therapi clinic assess determin degre right ventricular dysfunct critic initi risk stratif pe determin parenter versus oral anticoagul therapi direct oral anticoagul emerg prefer first line oral anticoagul strategi vte scenario | D000072096;D011655;D054556;D020246 | T097;T047;T046 |
34,686,266 | risk stratif manag extracrani carotid arteri diseas stroke fifth lead caus death unit state lead caus disabl extracrani intern carotid arteri stenosi major caus ischem stroke estim caus ischem stroke critic improv strategi stroke prevent treatment order reduc burden diseas herein review approach diagnosi risk stratif carotid arteri diseas well intervent strategi prevent treatment stroke caus carotid arteri diseas | D002340;D016893;D016894;D020521 | T047;T061;T020 |
34,686,265 | renovascular diseas mesenter vascular diseas renal arteri stenosi caus atherosclerosi fibromuscular dysplasia associ ischem nephropathi renovascular hypertens acceler cardiovascular diseas routin screen renal arteri stenosi recommend reason patient rapid onset hypertens resist hypertens progress renal insuffici recurr pulmonari edema repeat admiss heart failur acut mesenter ischemia caus arteri embol thrombosi mesenter venous thrombosi nonocclus mesenter ischemia wherea chronic mesenter ischemia often caus arteri obstruct articl review epidemiolog pathophysiolog diagnosi manag two condit | D050197;D005352;D006973;D006978;D012078 | T047;T046 |
34,686,264 | abdomin aortic viscer arteri aneurysm abdomin aortic aneurysm account near death annual ruptur abdomin aortic aneurysm thirteenth lead caus death unit state abdomin aortic aneurysm detect screen major detect incident viscer arteri aneurysm often discov incident treatment guid symptom etiolog size time diagnosi referr vascular specialist essenti time open endovascular repair ensur success patient outcom | D017544;D001019;D019917 | T047;T061 |
34,686,263 | thorac aortic aneurysm clinic review thorac aortic aneurysm common thorac aortic aneurysm degen howev associ connect tissu disord bicuspid aortic valv familialgenet predisposit asymptomat discov incident imag aortic diamet best predictor natur histori risk complic treat hypertens smoke cessat slow growth surveil imag referr prophylact aortic repair base absolut aneurysm diamet primari mean decreas mortal thorac aortic aneurysm provid practic evid base summari pathophysiolog risk factor associ genet syndrom clinic manag thorac aortic aneurysm | D000784;D017545;D000082882;D008382 | T047;T019;T046 |
34,686,262 | acut aortic syndrom acut aortic syndrom classifi aortic dissect intramur hematoma penetr aortic ulcer associ high earli mortal earli diagnosi manag crucial optim outcom patient often present nonspecif clinic symptom sign therefor import provid maintain high index suspicion acut aortic syndrom electrocardiogram gate comput tomograph angiographi chest abdomen pelvi current practic imag modal diagnosi identif complic evolut surgic techniqu develop aortic endograft improv patient outcom random trial still need | D000784 | T047;T046 |
34,686,261 | revascular strategi acut chronic limb ischemia chronic limb threaten ischemia requir aggress risk factor manag thought approach complex decis best strategi revascular patient often multilevel diseas amen endovascular open surgic hybrid approach limit high qualiti evid avail support specif strategi random trial ongo acut limb ischemia associ high risk limb loss mortal cathet direct thrombolysi mainstay therapi patient margin threaten limb wherea immedi threaten motor deficit requir rapid restor flow open endovascular techniqu establish flow singl set | D057510;D058729 | T047;T061 |
34,686,260 | medic manag peripher arteri diseas peripher arteri diseas high morbid yet undertr atherosclerot diseas cornerston peripher arteri diseas therapi consist smoke cessat lipid lower therapi hypertens treatment recent clinic trial demonstr novel antiplatelet antithrombot therapi reduc risk cardiovascular limb event patient popul review highlight compon optim medic therapi peripher arteri diseas evid base therapi | D050197;D058729 | T047;T046 |
34,686,237 | increment yield xpert mtbrif ultra xpert mtbrif diagnosi extrapulmonari tb background extrapulmonari tb eptb compris approxim tb case worldwid diagnosi difficult sensit xpert mtbrif xpert diagnosi eptb low account paucibacillari natur xpert mtbrif ultra ultra develop improv sensit object compar sensit ultra test xpert mgit mycobacteria growth indic tube cultur composit refer standard crs method recruit consecut treatment nave patient suspect eptb demograph inform clinic relev laboratori data collect result januari novemb patient provid sampl mgit cultur sensit ultra signific higher xpert vs p specif lower vs crs also sensit ultra signific higher xpert vs p howev specif similar vs trend toward higher sensit ultra compar xpert seen individu sampl sensit mgit crs follow lymph node vs p vs p pleural biopsi p ns vs p ns pleural fluid vs p ns vs p ns respect conclus xpert ultra show signific higher sensit diagnos eptb xpert | D000904;D009169;D014376 | T047;T195;T007 |
34,686,236 | monocyt lymphocyt ratio predictor tb among peopl live hiv background diagnost tool identifi incipi subclin tb stage help prevent intervent simpl biomark predict tb may monocyt lymphocyt ratio ml ratio peripher blood method assess relationship multipl time updat ml ratio measur incid tb peopl live hiv plwh antiretrovir therapi art initi ml ratio updat least everi month tb incid correspond confid interv stratifi accord time updat ml ratio calcul use ml ratio quartil result total plwh includ analys incid tb remain tb free tb incid rate ci case patient year pyr among particip ml ratio compar pyr ci among ml ratio cut point ml ratio provid diagnost area receiv oper characterist curv aroc ci sensit specif conclus increas ml ratio predict incid tb among plwh art ml ratio simpl tool stratifi risk tb plwh | D015658;D014376 | T047 |
34,686,235 | econom burden tb affect household dr congo background democrat republ congo free tb care polici recent progress univers health coverag insuffici remov barrier tb care access adher nation repres data econom burden born tb patient tb programm conduct nation survey assess proport tb patient face catastroph cost could also serv baselin monitor progress method nation survey retrospect data collect project follow method administ patient treatment zone patient interview cost time loss cope measur incom household expenditur asset ownership total cost express percentag annual household expenditur result household affect tb experienc cost annual household expenditur mean cost amount respect us rang us rang per episod first line drug resist tb risk catastroph cost increas hospitalis drug resist status lower econom status half household resort cope strategi experienc food insecur receiv social support conclus tb affect household incur averag cost us despit free tb care polici mitig burden medic cost reduct social labour market measur key | D017281;D014376 | T080;T047 |
34,686,234 | evalu later flow nanoparticl fluoresc assay tb infect diagnosi background programmat manag tb infect critic compon end tb strategi interferon gamma releas assay igra overcom limit tuberculin skin test implement igra test low resourc set challeng method feasibl studi evalu perform novel digit later flow assay qiareach quantiferon tb qiareach qft test quantiferon tb gold plus qft plus assay popul mix risk factor tb infect donor sampl multipl day total individu blood sampl test accord manufactur instruct result overal percentag agreement two side ci posit percentag agreement ie sensit ci negat percentag agreement ie specif ci qft plus posit specimen tb nil tb nil valu less iuml test posit qiareach qft conclus qiareach qft deploy accur test solut decentralis test potenti overcom key hurdl tb infect screen high burden set thus help achiev end tb programm goal | D055985;D053758 | T047;T073 |
34,686,233 | need caution interpret xpert mtbrif result rifampin resist among children background recommend world health organ initi diagnost test tb children xpert mtbrif wide implement mani countri includ kenya method three hundr hiv posit negat children year enrol kisumu counti kenya octob august multipl specimen type collect child test use xpert liquid cultur phenotyp drug suscept test dst sampl posit rifampin rif resist xpert test use line probe assay sequenc result children bacteriolog confirm tb posit xpert result ci rif resist detect xpert phenotyp dst line probe assay sequenc three children five xpert test show rif resist five test semi quantit low result delay absenc probe signal wherea xpert result higher semi quantit result show rif resist three children respond well standard tb treatment conclus fals rif resist may detect pediatr specimen studi need determin fals rif resist associ low bacteri load | D000904;D009169;D014397 | T047;T195;T007 |
34,686,232 | screen activ latent tb among migrant franc set migrant europ face disproportion burden infect includ tb yet littl known approach taken primari secondari care provid screen treatment therefor explor polici practic relat screen activ tb latent tb infect ltbi franc method conduct onlin nation survey french primari secondari care physician regard practic relat tbltbi screen among migrant result physician respond questionnair among primari care physician tb specialist secondari care physician involv daili care migrant respond recommend systemat tb screen chest x ray migrant medium high incid countri primari care physician less like offer screen physician set aor ci offer ltbi screen children year migrant high incid countri conclus improv awar tb screen critic next step improv health outcom migrant group meet region target tackl tb | D055985;D014171 | T047;T098 |
34,686,231 | pharmacokinet high dose isoniazid children affect multidrug resist tb background high dose isoniazid inh h mgkgday could administ overcom low level inh resist pharmacokinet data spars method observ studi includ south african children year receiv inh h prevent therapi treatment multidrug resist tb mdr tb exposur diseas pharmacokinet sampl perform inh dose mgkg non compartment analysi multivari regress model use evalu associ key covari area curv auc maximum concentr c max auc c max valu compar propos adult target result seventi seven children includ median age year mdr tb diseas mdr tb exposur five hiv posit four year old median auc ghml iqr c max gml iqr multivari analysi children age year mdr tb diseas vs exposur associ consider lower auc geometr mean ratio gmr ci p c max gmr ci p conclus inh concentr children mdr tb diseas much lower expect compar previous report children mdr tb exposur studi confirm find explor possibl caus | D007538;D018088 | T047;T121;T109 |
34,686,230 | advanc tb research use digit programmat data use real world data nation tb care program great potenti answer key research question tb control opportun due increas digit data collect storag summar expert stakehold workshop conduct topic octob perspect academ nation tb program offic data manag discuss challeng opportun use tb programmat data research describ digit data avail two larg high tb burden countri brazil south africa posit standard data collect set improv data manag greater collabor tb programmat data use research measur public health impact | D014376 | T047 |
34,686,222 | implant attach tube preserv knee extens nonunion felix iv fractur case report common util fix tissu muscl megaprosthes restor function stabil tumor surgeri attach tube use synthet reconstruct knee joint extens mechan nonunion felix iv c fractur fixat tibial fragment therefor osteointegr complic total knee arthroplasti caus tibial tubercl disloc | D057068;D013978 | T047;T037 |
34,686,220 | metastat choriocarcinoma young woman present thyroid storm case report thyroid storm endocrin emerg life threaten condit discov specif laboratori paramet differenti distinguish thyroid storm primari hyperthyroid diagnosi made clinic score system includ burch wartofski point scale japanes thyroid associ score system manag earli diagnosi immedi initi anti thyroid medic intens care monitor prevent multiorgan failur | D002822;D013958 | T191;T047 |
34,686,218 | stigma toward peopl covid among lebanes popul cross section studi correl mediat effect stigma develop outbreak covid pandem due human fear aris anxieti diseas unknown etiolog associ detriment consequ individu societi studi conduct assess knowledg covid attitud practic behavior regard prevent measur covid fear anxieti toward covid affect level stigma evalu mediat effect fear anxieti diagnosi covid stigma | D000086382;D058873 | T047;T067 |
34,686,217 | intracort diffus tensor imag signatur microstructur chang frontotempor lobar degener frontotempor lobar degener ftld neuropatholog construct multipl clinic present includ behaviour variant frontotempor dementia bvftd primari progress aphasia non fluent variant nfvppa semant variant svppa progress supranuclear palsi psp corticobas syndrom cbs characteris deposit abnorm tau protein brain major challeng treat ftld earli diagnosi accur discrimin among differ syndrom main goal investig cortic architectur ftld syndrom use cortic diffus tensor imag dti analysi test power discrimin differ clinic present | D057180;D057174;D013494 | T048;T047 |
34,686,215 | famotidin promot inflamm trigger cell pyroptosi gastric cancer cell cell pyroptosi character cell swell pro inflammatori factor releas aggrav inflammatori reaction interlukin beta il interlukin il howev function famotidin antagonist histamin h receptor antagonist cell pyroptosi remain unknown | D013274 | T191 |
34,686,211 | upregul cathepsin l gene mild cold condit young japanes male adult physiolog thermoregulatori system human key factor adapt local environ exodus africa particular cold environ outsid africa recent studi use high throughput sequenc identifi various gene respons cold adapt howev molecular mechan under initi thermoregul respons acut cold exposur remain unclear therefor investig transcript profil six young japanes male adult expos acut cold stress | D044466;D003080;D013312 | T121;T098;T039;T046;T032;T040;T070 |
34,686,210 | explor utilis alli health assist workforc victorian health age care disabl sector alli health assist aha support alli health profession ahp meet workforc demand modern healthcar system previous studi indic aha may underutilis context studi aim identifi factor contribut effect utilis aha across health age care disabl sector possibl pathway element may optimis aha career victoria | D000488;D006280 | T097;T081 |
34,686,209 | perform plasma aa ratio measur novel hplc msms method biomark amyloid pet status dpuk korean cohort assess feasibl plasma aa determin use novel liquid chromatographi mass spectrometri method lc ms use biomark pet status korean cohort dpuk studi | D000544;D053719 | T048;T047;T063 |
34,686,207 | surfaceom crispr screen identifi olfml rhinovirus induc ifn antagonist rhinovirus rvs caus half common cold case sever diseas function genom analys rvs use sirna genom wide crispr screen uncov limit set host factor proven clinic relev | D064113 | T040 |
34,686,203 | ultrasound guid five point inject botulinum toxin patient trapezius hypertrophi studi aim explor clinic therapeut effect ultrasound guid five point inject botulinum toxin type patient trapezius hypertrophi | D019274;D009465;D064171;D018084 | T116;T023;T121;T109;T129;T039;T131;T060 |
34,686,202 | health care manag commit toward implement citizen charter standard associ factor public hospit jimma zone southwest ethiopia manageri commit import effect design implement citizen charter assur qualiti health servic deliveri per standard depict document henc object studi assess level manageri commit toward implement citizen charter standard associ factor jimma zone public hospit | D003695;D006779 | T058;T093;T073 |
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