PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,682,309 | teach practic cognit behavior mind skill web base platform among older adult covid pandem pilot random control trial outbreak covid pandem led acceler develop web base intervent allevi relat mental health impact current studi explor effect short term digit group intervent aim provid cognit behavior mind tool skill reduc loneli depress increas social support among older adult israel pilot random control trial includ communiti dwell older adult n age year femal random either intervent group n wait list control group n intervent includ seven onlin session week depress loneli social support measur administ baselin immedi post intervent month follow repeat measur anova reveal statist clinic signific reduct depress intervent group result maintain one month follow loneli level also signific decreas post intervent howev benefit maintain one month follow social support slight increas post intervent month follow chang statist signific overal chang wait list control group intervent provid promis evid regard effect onlin group intervent allevi mental health effect promot cope older adult covid pandem relat simpl model effect util communiti global help connect lone isol older inhabit pandem routin time | D000086382;D064866 | T047;T041;T067 |
34,682,308 | melanin product chees bacteria chemic character biolog activ pigment compound import sever industri instanc food industri use addit color intensifi antioxid current trend around world shift use eco friend commod demand natur dye increas melanin pigment produc sever microorgan pseudomona putida esacb isol goat chees rind describ brown pigment produc strain produc brown pigment via synthet meller hinton broth brown compound extract purifi analyz ftir mass spectrometri identifi eumelanin maximum product mglh bioactiv eumelanin evalu capac scaveng free radic antioxid activ ec gml acetylcholinesteras inhibitor ic gml bacteri eumelanin show cytotox toward hela kyoto hepg caco cell line effect melanin cholesterol absorpt drug interact evalu order understand interact melanin present chees rind ingest consum howev effect either cholesterol absorpt intestin simul barrier form caco cell line drug ezetimib | D002611;D008543 | T168;T109;T123 |
34,682,307 | preval impact relat age effect competit perform swim systemat review systemat review aim examin preval relat age effect rae swim impact competit perform accord differ type interact constraint systemat literatur search follow prisma guidelin prepar systemat review perform four electron databas nine studi met inclus criteria qualiti select studi evalu use strobe averag score point obtain studi preval rae swim observ half particip analys effect rae accentu young categori decreas age increas invert older one male swimmer doubl femal swimmer impact rae competit perform appear relat strength demand event perform simultan stroke shorter event swimmer postadolesc period seem affect rae result indic rae competit swim reli individu environment swimmer age group gender also task competit event determin limit serv guid effect design select develop procedur young athlet | D054874;D013550 | T056;T055 |
34,681,960 | effect variat al content emiss eu dope caalsin red phosphor synthes combust synthesi method white led effect al content format photoluminesc properti caalsin eu phosphor casin investig combust synthesi method xrd x ray diffract combin pl photoluminesc tem ed transmiss electron microscop equip energi dispers x ray spectroscop sa select area electron diffract measur show bar like casin give stronger emiss plate like agglomer fine particl emiss intens increas al content increas al al result extent format casin increas emiss intens decreas al content increas al al result transform morpholog casin larg amount format aln addit extent format casin increas increas al al al begin decreas al increas thus peak emiss wavelength increas nm nm al molar ratio increas begin decreas increas al molar ratio result larg amount aln form | D049449 | T070 |
34,681,959 | stimulus respons smart nanoparticl base crispr cas deliveri therapeut genom edit innov research genom edit domain crispr cas technolog enabl genet engin manipul genom live organ effect order develop next generat therapeut tool techniqu start new era genom surgeri despit advanc barrier crispr cas techniqu clinic applic includ effici deliveri crisprca risk target effect various type viral non viral vector design deliv crisprca machineri desir cell method still suffer difficulti immun respons lack specif effici extracellular intracellular environ cell tissu differ ph redox speci enzym activ light sensit recent smart nanoparticl synthes crisprca deliveri cell base endogen ph enzym redox speci atp exogen magnet ultrasound temperatur light stimulus signal methodolog leverag genom edit biolog signal found within diseas cell less target effect review recent advanc stimulus base smart nanoparticl deliv crisprca machineri desir cell review articl provid extens inform cautious util smart nanoparticl basic biomed applic therapeut genom edit | D064113 | T040 |
34,681,958 | smart vitamin micell cancer nanomedicin enhanc intracellular deliveri doxorubicin chemotherapi one effect treatment cancer howev intracellular deliveri mani anticanc drug hinder hydrophob low molecular weight describ high biocompat biodegrad amphiphil vitamin conjug compris hydrophob vitamin e hydrophil vitamin b label dual ph glutathion respons degrad linkag vitamin base micell vitamicell form self assembl aqueous solut optim base stabil encapsul doxorubicin dox result vitamicell great potenti vehicl anticanc drug show excel biocompat h incub rapid biodegrad h compar free dox dox load vitamicell show mark enhanc anticanc effect releas drug rapid inhibit drug efflux cell effici exploit advantag studi provid promis strategi circumv exist challeng regard deliveri anticanc drug also extend util current dox induc chemotherapi | D008823 | T109 |
34,681,957 | design synthesi antibacteri antifung anticanc evalu novel pinen quaternari ammonium salt pinen monoterpen isol turpentin oil numer plant essenti oil broad spectrum biolog activ current work six novel pinen quaternari ammonium pqa salt synthes evalu vitro antifung antibacteri anticanc activ vitro assay result reveal compound b present remark antimicrobi activ test fungi bacteria particular compound show excel activ f oxysporum fsp niveum p nicotiana varnicotiana r solani pinea fusicoccumaesculi ec valu gml respect moreov compound show best antibacteri action e coli p aeruginosa aureus b subtili mic gml respect anticanc activ result demonstr compound b c f exhibit remark activ hct mcf cell line ic valu rang notabl compound c display strongest cytotox hct mcf cell line ic valu respect furthermor preliminari antimicrobi mechanist studi reveal compound might caus mycelium abnorm microbi cell membran permeabl chang inhibit activ atp altogeth find open interest perspect applic pqa salt novel lead structur develop effect antimicrobi anticanc agent | D015195 | T090 |
34,681,956 | full length transcriptom highlight coordin plastid transcript process plastid gene express involv mani post transcript matur step result complex transcriptom compos multipl isoform although short read rna seq consider improv understand molecular mechan control process unabl sequenc full length transcript inform crucial howev come understand interplay various step plastid gene express describ protocol studi plastid transcriptom use nanopor sequenc leaf arabidopsi thaliana million strand specif read map chloroplast genom could recapitul complex plastid transcriptom polygen transcript multipl isoform associ post transcript process use virtual northern blot even transcript longer nucleotid miss studi co occurr edit splice event identifi pair event occur independ studi also highlight preferenti chronolog matur event splice happen site edit | D017398;D018506;D059467 | T045;T123;T114;T081;T086 |
34,681,955 | biolog control leaf blight diseas caus pestalotiopsi maculan growth promot quercus acutissima carruth contain seedl use bacillus velezensi ce leaf blight diseas caus pestalotiopsi maculan lead deleteri loss qualiti forest contain seedl use plant growth promot bacteria provid promis strategi simultan control diseas enhanc forest seedl product studi investig biocontrol leaf blight diseas growth promot potenti bacillus velezensi ce quercus acutissima carruth seedl b velezensi ce produc cell wall degrad enzym chitinas l glucanas proteas caus cell wall lysi hypha deform p maculan lead myceli growth inhibit inocul b velezensi ce suppress p maculan infect increas seedl surviv rate fold fold compar chemic fertil control respect addit b velezensi ce produc indol acet acid improv root develop nutrient uptak compar chemic fertil control especi inocul b velezensi ce increas total nitrogen content q acutissima seedl improv chlorophyl index leav increas seedl biomass fold fold compar chemic fertil control respect thus b velezensi ce could appli eco friend product high qualiti forest seedl | D010572 | T068 |
34,681,954 | genet diabet learn drosophila diabet mellitus heterogen diseas character hyperglycemia due impair insulin secret andor action diabet type strong genet compon frequent form type diabet td type diabet td gestat diabet mellitus gdm multifactori syndrom associ sever gene effect togeth environment factor convers rare form neonat diabet mellitus ndm matur onset diabet young modi caus mutat singl gene larg scale genom screen led identif hundr putat causat gene multigen diabet loci identifi far explain small proport herit nevertheless sever recent studi allow identif gene causat also putat target new drug although monogen form diabet suit perform precis approach allow accur diagnosi least monogen case remain still undiagnos knowledg acquir far address futur work toward studi focus identif diabet causal variant aim reach combin expertis differ area perspect model organ research crucial review trace overview genet diabet main focus drosophila model system describ fli contribut diabet knowledg advanc | D004195;D004843;D059647;D020022 | T032;T050;T028;T045 |
34,681,953 | eltd activ induc endotheli emt transit myofibroblast phenotyp eltd express endotheli vascular smooth muscl cell role angiogenesi classifi adhes gpcr yet ligand identifi function remain unknown establish role eltd overexpress endotheli cell express consequ ligand independ activ eltd result endotheli mesenchym transist endmt loss cell cell contact format stress fibr matur focal adhes increas express smooth muscl actin effect pro angiogen increas matrigel network format endotheli sprout rna seq analysi cell undergon endmt reveal larg increas chemokin cytokin involv regul immun respons gene set enrich analysi data identifi number pathway involv myofibroblast biolog suggest endotheli cell undergon type ii emt type emt involv wound repair close associ inflamm implic eltd process | D058750;D005786;D009389 | T043;T046;T045 |
34,681,951 | role emerin cancer progress metastasi common recogn field cancer cell exhibit chang size shape nuclei featur often serv import biomark diagnosi prognosi cancer patient nuclear size signific impact cell migrat due incred larg size nuclear structur chang predict regul cancer cell migrat nuclear abnorm common across vast spectrum cancer type regardless tissu sourc mutat spectrum signal depend pervas nuclear alter suggest chang nuclear structur may crucial link transform process factor drive nuclear abnorm function consequ complet understood nuclear envelop protein play import role regul nuclear size structur cancer alter express nuclear lamina protein includ emerin found mani cancer express correl better clinic outcom model emerg wherebi emerin well nuclear lamina protein bind nucleoskeleton regul nuclear structur impact metastasi model emerin lamin play central role metastat transform sinc decreas emerin express transform caus nuclear structur defect requir increas cell migrat intravas extravas herein discuss cellular function nuclear lamina protein particular focus emerin function impact cancer progress metastasi | D009154 | T045 |
34,681,950 | genom wide identif express analysi rr myb famili gene associ petal pigment synthesi liriodendron myb transcript factor famili one largest famili plant member various biolog function rr myb gene involv synthesi pigment yield petal color liriodendron plant wide cultiv ornament tree owe peculiar leav tulip like flower color petal howev mechan under petal color speci unknown minim inform myb gene liriodendron avail herein studi aim discern gene involv petal color liriodendron via genom wide identif hplc rt qpcr assay total lcmyb superfamili gene identifi liriodendron chinens genom rr myb gene map onto chromosom chromosom contain rr myb gene chromosom contain fewest one meme analysi show rr myb protein l chinens high conserv exon intron structur vari hplc result show three major carotenoid uniform distribut petal l chinens lycopen caroten concentr orang band region petal liriodendron tulipifera furthermor express profil via rt qpcr assay reveal four rr myb gene express highest level spsp stage l tulipifera result combin hplc result show four rr myb gene might particip carotenoid synthesi petal l tulipifera work laid cornerston function character rr myb gene liriodendron plant | D018506;D020570;D018745 | T028;T045 |
34,681,949 | ehmtga epigenet target pediatr adult brain tumor epigenet mechan includ post translat modif dna histon influenc chromatin structur regul gene express normal develop also involv carcinogenesi cancer progress histon methyltransferas ga euchromat histon lysin methyltransferas ehmt most mediat mono dimethyl histon h lysin hk influenc gene express involv embryon develop tissu differenti overexpress ga observ sever cancer type differ class ga inhibitor develop potenti anticanc agent review emerg evid suggest involv chang ga activ brain tumor name glioblastoma gbm main type primari malign brain cancer adult medulloblastoma mb common type malign brain cancer children also discuss role ga neuroblastoma nb drug develop ga inhibitor | D019175;D044127 | T044;T045 |
34,681,947 | respons sphagneticola trilobata sphagneticola calendulacea hybrid drought stress sphagneticola trilobata invas plant south china hybrid trilobata sphagneticola calendulacea nativ relat speci also found south china drought resist calendulacea trilobata hybrid studi paper drought stress leav trilobata synthes abscis acid aba speci reduc stomat open water loss activ antioxid enzym highest trilobata lowest calendulacea leav calendulacea suffer serious damag maximum photochem effici lowest rna sequenc ware use analyz express level gene aba antioxid enzym sugar prolin synthesi photosynthesi pathway real time pcr detect verifi rna sequenc result result accord physiolog data result show trilobata drought toler drought toler hybrid show heterosi higher calendulacea therefor compar trilobata hybrid popul number distribut calendulacea may less arid area | D055864;D018506;D010788;D013312 | T044;T121;T045;T039;T046;T032;T040;T070 |
34,681,944 | alveolar regener covid patient network perspect viral infect involv entri replic viral nucleic acid host organ subsequ lead biochem structur alter host cell case sar cov viral infect activ host immun system may lead lung damag albeit regener fibrot repair process two protect host respons prolong injuri may lead excess fibrosi patholog state result lung collaps review discuss regener fibrosi process respons sar cov provid viewpoint trigger alveolar regener coronavirus diseas covid patient | D012038 | T042 |
34,681,938 | investig pathogenet mechan alzheim diseas system biolog approach drug discoveri alzheim diseas ad common caus dementia character progress cognit declin neurodegen disord abnorm aggreg intracellular neurofibrillari tangl nfts unusu accumul extracellular amyloid peptid two import patholog featur ad brain howev spite larg scale clinic studi comput simul molecular mechan ad develop progress still unclear studi divid sampl two group earli stage braak score iii later stage braak score iv vi big databas mine candid genet epigenet network gen construct order find real gen two stage ad perform system identif system order detect scheme prune fals posit help correspond microarray data appli princip network project pnp method core gen extract real gen base project valu annot kegg pathway could obtain core pathway core gen investig pathogenet mechan earli later stage ad respect consequ accord pathogenet mechan sever potenti biomark identifi drug target multipl molecul drug design treatment ad | D055808;D044127;D049490 | T091;T062;T045 |
34,681,934 | nuclear mrna qualiti control cytoplasm nmd link guard protein gbp hrb pre mrna splice critic cell defect process lead alter open read frame defect protein potenti caus neurodegen diseas cancer intron remov nucleus splice document addit exon junction complex ejc exon exon boundari memori splice event import ribosom translat rnas cytoplasm case stop codon detect ejc translat block rna elimin nonsens mediat decay nmd model organ saccharomyc cerevisia two guard protein gbp hrb identifi nuclear qualiti control factor splice absenc intron contain mrnas leak cytoplasm presenc retain transcript process complet releas mrnas recruit export factor mex transcript experi splice problem guard protein recruit nuclear rna degrad machineri interest continu qualiti control function export transcript support nmd inhibit translat recruit cytoplasm degrad factor way link nuclear cytoplasm qualiti control system discoveri also intrigu human homologu guard protein present also multicellular organ provid overview qualiti control mechan pre mrna splice present gbp hrb well human counterpart import player pathway | D059365;D011786 | T169;T045 |
34,681,932 | function ppr protein plant growth develop pentatricopeptid repeat ppr protein form larg protein famili land plant hundr differ member angiosperm last decad number studi shown ppr protein sequenc specif rna bind protein involv multipl aspect plant organellar rna process perform numer function plant throughout life cycl recent comput structur studi provid new insight work mechan ppr protein rna recognit cytidin deamin review summar research progress function ppr protein plant growth develop particular focus effect cytoplasm male steril stress respons seed develop also document molecular mechan ppr protein mediat rna process plant mitochondria chloroplast | D018506;D063245 | T040;T038;T045 |
34,681,931 | oleanol acid semisynthet deriv himoxol br himolid show proautophag potenti inhibit migrat posit breast cancer cell vitro approxim diagnos breast cancer overexpress human epiderm growth factor receptor type cancer associ aggress phenotyp thus need discoveri new compound would improv surviv posit breast cancer patient seem one promis therapeut cancer strategi could base biolog activ pentacycl triterpen deriv best known repres group oleanol acid oa biolog activ oleanol acid two semisynthet deriv methyl hydroxyimino oxoolean en oat himoxol bromo hydroxyimonoolean olid br himolid assess sk br breast cancer cell posit viabil test cell cycl assess evalu apoptosi autophagi adhesionmigr process perform use mtt clonogen cytofluorometri western blot qpcr deriv reveal higher cytotox studi breast cancer cell matern compound oa also decreas cell viabil induc autophagi appli sub cytotox concentr decreas migrat sk br cellsthi studi first report cytostat proautophag mtorlcsqstmbecn pathway anti migratori integrin fakpaxillin pathway activ himoxol br himolid posit breast cancer cell | D001343 | T043 |
34,681,930 | advanc nanotechnolog toward develop silver nanoparticl base wound heal agent sinc antiqu silver base therapi use wound heal wound care manag infect provid adequ heal therapi associ certain limit toxic skin discolour bacteri resist limit use result new innov wound therapi strategi improv exist therapi sought silver nanoparticl agnp shown potenti circumv limit associ convent silver base therapi describ agnp effect broad spectrum microorgan less toxic effect lower concentr produc skin discolour furthermor agnp decor coupl heal promot materi provid optimum heal review detail histori impact silver base therapi lead agnp agnp base nanoformul wound heal also highlight properti agnp aid wound heal make superior convent silver base wound treatment therapi | D014945 | T040 |
34,681,928 | snapin specif regul ca v ca channel variant long carboxyl terminus ca entri ca v ca channel play essenti role divers physiolog event employ yeast two hybrid yh assay mine novel protein interact ca v found snapin synapt protein partner interact long carboxyl terminus ct l rat ca v l variant co express snapin ca v l ca v subunit increas peak current densiti amplitud fold hek cell xenopus oocyt without affect voltag depend gate properti calcium depend inactiv howev snapin regul effect found rat ca v contain short ct ct snapin interact site ct l defici luminometri electrophysiolog studi uncov snapin co express alter membran express ha tag ca v l increas slope tail current amplitud plot gate current indic snapin increas open probabl ca v l taken togeth result strong suggest snapin direct interact ct l ca v l lead regul ca v l channel activ via facilit channel open probabl | D015854 | T044 |
34,681,918 | sod enhanc long term inhibit pik pathway confer multi drug resist enhanc tumor initi featur head neck cancer phosphoinositid kinas pik pathway wide consid potenti therapeut target head neck cancer hnc howev applic pik inhibitor often overshadow induct drug resist unknown mechan studi piik inhibitor resist cancer cell develop prolong cultur cell line bez dual pik mammalian target rapamycin mtor inhibitor drug resist hnc cell show higher ic prolifer inhibitor specif target pik andor mtor compar parent cell cell also show profound resist drug class molecular analysi reveal persist activ phosphoryl akt threonin drug resist cell increas express marker tumor initi cell interest increas intra cellular ros level observ drug resist cell among anti oxid molecul express sod increas associ aldh posit tumor initi cell featur co incub sod inhibitor bez decreas stem featur cell vitro shown result spheroid format assay conclus dysregul sod might contribut profound resist pik inhibitor drug hnc cell | D019008 | T042;T038 |
34,681,910 | myelodysplast syndrom metabol myelodysplast syndrom mds acquir clonal stem cell disord exhibit ineffect hematopoiesi dysplast cell morpholog bone marrow peripher cytopenia earli stage advanc stage carri high risk transform acut myeloid leukemia aml genet alter integr pathogenesi mds howev remain unclear genet chang hematopoiet stem progenitor cell hspcs occur confer expans advantag clone carri recent inflammatori process chang cellular metabol hspcs surround bone marrow microenviron associ age relat dysfunct hspcs emerg genet aberr relat clonal hematopoiesi indetermin potenti chip present review highlight involv metabol inflammatori pathway regul hspc nich cell function mds comparison healthi state discuss pathway may amen therapeut intervent | D053858 | T044;T169 |
34,681,909 | macrophag depend interleukin product inhibit ik contribut acquir qt prolong lipotox guinea pig heart heart delay rectifi k current ik compos rapid ikr slow ik compon contribut promin normal cardiac repolar lipotox chronic elev pro inflammatori cytokin may remodel ik elev risk ventricular arrythmia sudden cardiac death investig whether pro inflammatori interleukin alter ik heart use electrophysiolog evalu chang ik adult guinea pig ventricular myocyt found palmit acid potent induc lipotox induc rapid h signific increas il raw cell pa diet fed guinea pig display sever prolong qt interv compar low fat diet fed control exposur isoproterenol induc torsad de point ventricular fibril lipotox guinea pig pre exposur il solubl il receptor produc profound depress ikr ik densiti prolong action potenti durat impair mitochondri atp product inhibit ikr proarrhythm phenotyp ik depress emerg manifest prolong action potenti durat qt interv data offer uniqu mechanist insight implic patholog qt interv patient vulner fatal arrhythmia | D000200 | T043 |
34,681,904 | ak new catalyt inhibitor topoisomeras ii anti prolif pro apoptot activ androgen negat prostat cancer cell castrat resist prostat cancer crpc clinic challeng treatment aggress natur resist androgen depriv therapi topoisomeras ii catalyt inhibitor suggest strategi overcom issu previous report ak novel topoisomeras ii inhibitor studi mechan ak clarifi use various type spectroscop biolog evalu ak show potent topoisomeras ii inhibitori activ intercal dna without stabil dna enzym cleavag complex result signific less dna toxic etoposid clinic use topoisomeras ii poison ak induc g arrest effect inhibit cell prolifer coloni format combin paclitaxel androgen receptor negat crpc cell line result confirm topoisomeras ii catalyt inhibit inhibit prolifer induc apoptosi ar independ grow prostat cancer cell find indic clinic relev topoisomeras ii catalyt inhibitor androgen receptor negat prostat cancer | D017209;D049109 | T043;T116;T123 |
34,681,901 | autoinflammatori diseas cytokin storm imbal innat adapt immun innat adapt immun respons well known link repres distinct origin sever diseas mani may consequ loss balanc two respons inde autoinflamm autoimmun repres two extrem continu spectrum patholog condit numer overlap differ patholog common characterist dysregul repres hyperinflamm exagger respons immun system especi involv white blood cell macrophag inflammasom activ hyperproduct cytokin respons various trigger stimuli moreov hyperinflamm great interest one main manifest covid infect cytokin storm import compon target pharmacolog treatment use combat covid damag context purpos review provid focus pathogenesi autoinflamm particular hyperinflamm order generat insight identif new therapeut target strategi | D056704;D007113 | T040;T032;T039 |
34,681,900 | long intergen noncod rna oin promot ovarian cancer growth modul apoptosi relat gene express patient advanc ovarian cancer usual exhibit high mortal rate thus effici therapeut strategi expect develop recent transcriptom studi reveal long intergen noncod rnas lincrna new class molecular target cancer manag lincrna like exert tissu specif activ compar protein code gene noncod rnas show unannot lincrna origin chromosom q design ovarian cancer long intergen noncod rna oin often overexpress ovarian cancer tissu compar normal ovari analyz rna sequenc oin silenc specif sirna signific exert prolifer inhibit enhanc apoptosi ovarian cancer cell notabl rna sequenc show oin express negat correl express apoptosi relat gene ras associ domain famili member rassf adenosin receptor adora upregul oin knockdown ovarian cancer cell oin specifc sirna inject effect suppress vivo tumor growth ovarian cancer cell inocul immunodefici mice taken togeth oin could function tumor promot lincrna ovarian cancer modul apoptosi potenti molecular target ovarian cancer manag | D015972 | T045 |
34,681,898 | antileukem natur product induc apoptot pyroptot program cell death differenti effect acut myeloid leukemia aml one common form leukemia despit advanc manag malign progress novel therapi unmet medic need still exist aml sever factor includ poor respons chemotherapi high relaps rate ardisianon plant deriv natur compon alkyl benzoquinon structur induc apoptosi leukem hl cell determin dozen apoptosi relat protein show ardisianon upregul death receptor downregul inhibitor apoptosi protein iap western blot show ardisianon induc dramat increas tumor necrosi factor receptor tnfr protein express ardisianon also induc downstream signal activ caspas degrad bid caspas substrat furthermor ardisianon induc degrad dna fragment factor kda dff subunit inhibitor caspas activ dnase icad q vd oph broad spectrum caspas inhibitor signific diminish ardisianon induc apoptosi confirm involv caspas depend apoptosi moreov ardisianon induc pyroptosi use transmiss electron microscop examin western blot analysi key marker includ gasdermin high mobil group box hmgb caspas detect notabl ardisianon induc differenti remain surviv cell character increas express cdb cd two marker macrophag monocyt wright giemsa stain also show differenti cell monocyt macrophag morpholog conclus data suggest ardisianon induc apoptosi pyroptosi leukem cell downregul iap activ caspas pathway caus gasdermin cleavag dna doubl strand break ultim led program cell death ardisianon also induc differenti leukem cell monocyt like macrophag like cell data suggest potenti ardisianon antileukem develop | D002454;D000069292 | T043 |
34,681,897 | suppress estrogen receptor alpha inhibit cell prolifer differenti enhanc chemosensit p posit uo osteosarcoma cell osteosarcoma high malign musculoskelet tumor common notic adolesc children young children elder adult due advanc surgeri chemotherapi imag technolog surviv rate improv chemic treatment enhanc patient surviv addit surviv rate chemic treatment still low obvious clinic featur osteosarcoma new bone format call sun burst estrogen receptor alpha er essenti featur osteogenesi regul cell growth various tumor includ osteosarcoma studi sought investig role er osteosarcoma determin er use target facilit chemosensit osteosarcoma current treatment growth rate cell clone assay mtt trypan blue cell count cell cycl analysi conduct flow cytometri osteogen differenti induc osteogen induct medium quantifi ar stain effect er chemorespons os cell treat doxorubicin evalu coloni format assay mechanist studi conduct examin level protein western blot role er os prognosi investig immunohistochem analysi os tissu array result show impair growth rate decreas osteogenesi abil er silenc p os cell line uo p sao cell compar parent cell line cotreat tamoxifen estrogen receptor inhibitor increas sensit doxorubicin decreas coloni format p uo cell cell cycl arrest phase observ p uo cell cotreat low dose doxorubicin tamoxifen increas level apoptosi factor indic cell death moreov patient er p uo show better chemorespons rate necrosi rate impair tumor size compat find basic research taken togeth er may potenti target current treatment osteosarcoma control tumor growth improv chemosensit addit express er osteosarcoma prognost factor predict respons chemotherapi | D019008;D015972 | T042;T038;T045 |
34,681,896 | nanosecond puls electr field transient affect cellular molecular process leydig cell purpos studi verifi whether nanosecond puls electr field elicit thermal effect perman chang molecular process gene express leydig tm cell cell expos moder electr field quasi rectangular shape puls ns puls width electr field kvcm putat disturb record h exposur nanosecond puls electr field increas cell diamet loss microvilli reduct cell adhes observ cell show nonapoptot extern phosphatidylserin pore plasma membran cell proport subg phase increas expens gm phase dna fragment small proport cell membran mitochondri potenti superoxid content decreas respect microarray transcriptom analysi demonstr negat transient effect express gene involv oxid phosphoryl dna repair cell prolifer overexpress plasma membran protein conclud nanosecond puls electr field affect physiolog gene express tm cell transient notic heterogen cellular respons | D004560 | T070 |
34,681,891 | sugar transport metabol signal fruit develop litchi chinensi sonn review litchi chinensi sonn import evergreen fruit crop cultiv tropic subtrop region edibl portion litchi fruit aril contain high concentr sucros glucos fructos studi review various aspect sugar transport metabol signal fruit develop litchi begin detail sugar transport accumul aril develop biosynthesi quebrachitol transport photosynth discuss document sugar metabol litchi fruit focus link sugar signal seed develop well fruit absciss final outlin futur direct research sugar metabol signal improv fruit yield qualiti | D018506 | T045 |
34,681,890 | control releas doxorubicin target chemo phototherm therapi breast cancer hst cell use albumin modifi hybrid nanocarri hybrid nanomateri attract research interest owe intrigu properti may offer new diagnost option trigger featur abl realiz new kind tunabl nanotherapeut hybrid silicamelanin nanoparticl nps contain silver seed lasilag hsa nps disclos relev photoacoust contrast molecular imag studi explor therapeut function nanoplatform purpos melasilag hsa load doxorubicin dox melasilag hsa dox test assess effici drug deliveri combin concurr phototherm treatment excel phototherm properti allow enhanc cytotox activ signific lower dose neat chemotherapeut treatment result reveal melasilag hsa dox promis platform integr phototherm pt chemotherapi approach reduc efficaci concentr dox thus potenti limit sever advers side effect drug vivo treatment | D016503 | T074 |
34,681,889 | irisin protect human placenta oxid stress apoptosi via activ akt signal pathway irisin newli discov exercis mediat polypeptid hormon irisin level increas pregnanc howev women preeclampsia pe signific lower level irisin compar women healthi pregnanc even though mani studi suggest role irisin pregnanc function human placenta unclear current studi aim understand key role irisin abil protect apoptosi preeclampt placenta ex vivo vitro model hypoxiar oxygen hr injuri studi show irisin prevent cell death reduc pro apoptot signal cascad reduc cleavag parp induc dna repair pathway reduc activ caspas irisin caus increas level anti apoptot bcl pro apoptot bax reduc ros level vitro model placent ischemia furthermor show irisin treatment act akt signal pathway prevent apoptosi enhanc cell surviv find provid novel understand anti apoptot pro surviv properti irisin human placenta patholog condit work yield new insight placent develop diseas point toward intervent strategi placent insuffici pe protect maintain placent function inhibit hypox ischemia induc apoptosi | D017209;D018384 | T043;T116;T049;T123 |
34,681,888 | dynam germinosom format fret base analysi interact gerd germin receptor subunit bacillus cereus spore spore bacterium bacillus cereus caus diseas human due contamin raw materi food manufactur dormant resist spore surviv year environ germin grow surround becom suitabl spore germin protein play import role decis germin sinc germin spore lost dormant spore extrem resist knowledg format function germin protein could use suggest new preserv strategi control b cereus spore studi confirm gerr germin receptor gr b c subunit gerd co local b cereus spore inner membran im foci term germinosom interact protein examin use fusion fluoresc report protein sgfp mscarlet frster reson energi transfer fret work found fret effici gerr c b sgfp gerd mscarlet fret gerd mscarlet either gerra sgfp gerrc sgfp result gerd interact gr c subunit vitro suggest germinosom gerd interact primarili gr b subunit dynam format germinosom gerr c b sgfp gerd mscarlet also follow sporul result show heterogen format fret posit foci gerr c b sgfp gerd mscarlet foci form time format foci fret channel could signific delay latter find suggest either gerr gr least transient form im foci absenc gerd gerd essenti gerr foci format time attain final germinosom structur close contact gerd gerr heterogen | D054730 | T116;T082;T123 |
34,681,887 | silico vivo analysi amino acid substitut caus laminopathi mutat lmna gene caus diseas call laminopathi lmna encod lamin c intermedi filament multipl role nuclear envelop lmna mutat frequent singl base chang caus divers diseas phenotyp affect muscl nerv fat diseas associ amino acid substitut map silico onto three dimension structur lamin ac reveal appar genotyp phenotyp connect silico analys reveal seven nine predict partner protein bind pocket ig like fold domain correspond site diseas associ amino acid substitut differ amino acid substitut posit within lamin ac caus distinct diseas rais question whether natur amino acid replac genet background differ contribut diseas phenotyp substitut r rod domain caus muscular dystrophi vari sever address variabl model rq rw drosophila lamin c orthologu lmna larval bodi wall muscl express mutant lamin c caus abnorm nuclear morpholog prematur death express indirect flight muscl rw caus greater number adult wing postur defect rq consist observ rw rq caus distinct muscular dystrophi rw sever case natur amino acid replac appear dictat muscl diseas sever togeth find illustr util drosophila predict muscl diseas sever pathogen variant unknown signific | D003198;D009154 | T066;T045 |
34,681,886 | advanc nanoparticl drug deliveri system anti hepat b virus therapi narrat review chronic hepat b chb infecti viral diseas preval worldwid tradit nucleosid analogu well novel drug target hepat b virus hbv associ certain critic factor influenc curat effect biolog stabil safeti effect drug deliveri control releas nanoparticl drug deliveri system signific advantag provid basi develop anti hbv strategi review aim review advanc nanoparticl drug deliveri system anti hepat b virus therapi summar relev literatur first focus characterist nanoparticl drug deliveri system anti hbv therapi second discuss nanoparticl deliveri system anti hbv nucleosid drug gene base drug vaccin last provid overview prospect nanoparticl base anti hbv agent | D016503 | T074 |
34,681,885 | long term immun respons produc sputnikv vaccin sputnikv vaccin sar cov develop gamaleya nation research centr epidemiolog microbiolog vaccin shown induc humor cellular immun respons yet mechan remain larg unknown forti sputnikv vaccin individu includ studi aim demonstr locat immunogen domain sar cov protein use overlap peptid librari addit cytokin serum vaccin convalesc covid patient analyz found antibodi vaccin convalesc sera bind immunogen region locat multipl domain sar cov protein includ receptor bind domain rbd n termin domain ntd fusion protein fp heptad repeat hrs interest mani peptid recogn immun convalesc serum antibodi correspond conserv region circul variant sar cov breadth reactiv still evid day first dose vaccin show vaccin induc prolong respons evidenc activ cell cellular immun strong suggest high potenc sputnikv vaccin sar cov infect | D007111;D056724 | T040;T043 |
34,681,884 | therapeut effect msh primari cultur orbit fibroblast obtain patient thyroid eye diseas inflamm hyaluronan product adipogenesi main patholog event lead thyroid eye diseas ted melanocytemelanocyt stimul hormon msh well known tridecapeptidetreat sever inflammatori disord includ sepsi syndrom acut respiratori distress syndrom rheumatoid arthriti enceph investig effect msh treatment ted dimethylthiazol yl diphenyltetrazolium bromid mtt lactat dehydrogenas ldh assay perform analyz effect msh cell viabil toxic use primari cultur orbit fibroblast ted patient non ted control examin effect msh proinflammatori cytokin product induc interleukin il analyz real time revers transcript polymeras chain reaction qpcr western blot immunofluoresc stain assay qpcr perform examin proopiomelanocortin pomc express upstream neuropeptid msh ted patient non ted control treatment non cytotox concentr msh result dose depend inhibit mrna protein level p il induc inflammatori cytokin il il mcp icam cox express pomc mrna protein signific higher ted patient compar non ted control p data show signific inhibitori effect msh inflamm pomc product orbit fibroblast present first vitro preclin evid msh therapeut effect ted find indic pomc msh may play role immun regul ted potenti therapeut target | D005786 | T045 |
34,681,883 | histon deacetylas inhibit regul lipid homeostasi mous model amyotroph later sclerosi amyotroph later sclerosi al incur fatal neurodegen disord motor system etiolog still incomplet understood defect metabol act major contributor diseas progress recent histon deacetylas hdac inhibit use aci shown restor metabol alter spinal cord fus mous model al accompani benefici effect motor phenotyp surviv studi investig specif effect hdac inhibit lipid metabol use untarget lipidom analysi combin transcriptom analysi spinal cord fus mice discov symptomat fus mice recapitul lipid alter found al patient sod mous model glycerophospholipid sphingolipid cholesterol ester affect strike hdac inhibit mitig lipid homeostasi defect select target glycerophospholipid metabol reduc cholesteryl ester accumul therefor data suggest hdac inhibit potenti new therapeut strategi modul lipid metabol defect al potenti neurodegen diseas | D004195 | T050 |
34,681,882 | cellular signal photobiomodul chronic wound repair photobiomodul pbm impart therapeut signific benefit heal chronic wound chronic wound develop stage wound heal fail progress time order frame without establish function structur outcom therapeut benefit associ pbm includ augment tissu regener repair mitig inflamm reliev pain reduc oxid stress pbm stimul mitochondria result increas adenosin triphosph atp product downstream releas growth factor bind growth factor cell surfac receptor induc signal pathway transmit signal nucleus transcript gene increas cellular prolifer viabil migrat numer cell type includ stem cell fibroblast past year signific advanc made understand pbm regul numer signal pathway implic chronic wound repair review highlight signific role pbm activ sever cell signal pathway involv wound heal | D014945 | T040 |
34,681,880 | investig molecular mechan hb splice modul induc preferenti lethal spliceosom mutant cancer sfb protein part sfb complex recogn intron branch point sequenc precursor messeng rna pre mrna thus contribut splice fidel sfb frequent mutat cancer target distinct famili splice modul sms among hb particular interest induc preferenti lethal cancer cell bear frequent high pathogen ke sfb mutat despit potenti hb treat myeloid leukemia cancer type hallmark sfb mutat molecular mechan under preferenti lethal toward spliceosom mutant cancer cell remain elus microsecond long atom simul address bindingdissoci mechan hb wild type ke sfb contain sfb ke sbb complex atom level unlock ke mutat littl affect thermodynam kinet trait hb bind support hypothesi select hb toward mutant cancer cell unrel preferenti target ke sbb nevertheless set simul disclos ke mutat hb bind affect overal sfb intern motion turn may influenc way sfb interact spliceosom compon final unveil exist putat druggabl sfb pocket vicin ke could har futur ration drug discoveri effort specif target mutant sfb | D009154;D012326 | T045 |
34,681,876 | phytoestrogen resveratrol equol estrogen defici skin controversiesmisinform versus anti age vitro clinic evid via nutraceut cosmet overarch theme review perspect superfood market term fruit veget etc posit connot mani superfood contain phytoestrogen term alarm public negat connot phytoestrogen endocrin disruptor even though strong antioxid mani health benefit understand phytoestrogen paper provid brief summari characterist estrogen b estrogen receptor er c estrogen defici skin perspect get track e phytoestrogen food sourc f misconcept phytoestrogen food safeti general influenc person away true final brief histori cosmet nutraceut cover plus characterist phytoestrogen resveratrol equol g estrogen receptor bind h topic oral dose vitro molecular mechan select clinic evid phytoestrogen resveratrol equol demonstr promis applic improv skin health present along futur direct nutraceut perspect paramount understand controversi associ superfood phytoestrogen endocrin disruptor posit negat connot everyon expos consum molecul everyday regardless age gender geograph locat around world understand matter perspect | D000375 | T040;T033 |
34,681,875 | progranulin promot compensatori hepatocyt prolifer via hgfc met signal partial hepatectomi zebrafish compensatori hepatocyt prolifer liver regen process activ sustain normal physiolog function liver injuri major mitogen liver regener hepatocyt growth factor hgf previous studi indic progranulin could modul c met receptor hgf initi hepat outgrowth hepatoblast embryon develop howev role progranulin compensatori hepatocyt prolifer shown previous therefor studi undertaken clarifi whether progranulin play regulatori role liver regener end establish partial hepatectomi regener model adult zebrafish express liver specif fluoresc report use model found loss progranulin grna function intraperiton inject vivo morpholino impair delay liver regener partial hepatectomi furthermor transcriptom analysi confirmatori quantit real time pcr suggest cell cycl progress cell prolifer activ morphant control may result compar downregul hgfc met axi h partial hepatectomi final liver specif overexpress grna transgen zebrafish caus abund cell prolifer partial hepatectomi compar wild type thus conclud grna posit regul hgfc met signal promot hepatocyt prolifer liver regener | D008115 | T042 |
34,681,872 | tension stimul tenocyt align hyaluron acidplatelet rich plasma polycaprolacton core sheath nanofib membran scaffold tendon tissu engin recreat vivo nich tendon tissu engin vitro characterist tendon tissu underlin use biochem biophys cue tenocyt cultur herein prepar core sheath nanofib polycaprolacton pcl sheath mechan support hyaluron acid ha platelet rich plasma prp core growth factor deliveri three type core sheath nanofib membran scaffold csnms consist random ha pcl nanofib random random haprp pcl nanofib random align haprp pcl align nanofib use studi respons rabbit tenocyt biochem prp biophys fiber align stimul core sheath structur well pertin properti csnms character align show best mechan properti unidirect growth tenocyt induc align fiber topographi confirm cell morpholog cytoskeleton express combin effect prp fiber align align csnms lead enhanc cell prolifer rate well upregul gene express marker protein synthesi anoth biophys cue tenocyt introduc dynam cultur tenocyt seed align bioreactor cyclic tension stimul augment biophys beacon mechan load dynam cell cultur could shorten time tendon matur vitro improv cell prolifer rate tenogen phenotyp mainten compar static cultur therefor success demonstr combin use biochemicaltopograph cue well mechan stimul could amelior cellular respons tenocyt csnms provid function vitro environment nich tendon tissu engin | D013710;D000070916 | T025;T023 |
34,681,869 | il may play import role develop eosinophil chronic rhinosinus eosinophil otiti media sever asthma woman super respond benralizumab administ treatment sever bronchial asthma ba eosinophil chronic rhinosinus nasal polyp ecr eosinophil otiti media eom exhibit gradual exacerb ecrseom despit good control ba approxim year benralizumab initi therefor treatment switch dupilumab condit paranas sinus middl ear great improv best control asthma patient report physic condit best life howev develop pulmonari opac chest comput tomographi month histolog examin lung parenchyma cell differenti bronchoalveolar lavag fluid indic atyp chronic eosinophil pneumonia treatment switch mepolizumab similar period benralizumab treatment exacerb ecrseom reduc qualiti life approxim month administr mepolizumab dupilumab introduc replac mepolizumab clinic cours consider interact inflammatori cell led us specul interleukin could play key role develop ecrseom sever ba | D018793 | T129;T116 |
34,681,868 | molecular cytogenet analysi introgress agropyron cristatum p genom wheat genom agropyron cristatum n x pppp import wild relat common wheat triticum aestivum l n x previous report show wheat cristatum p transloc line wat carri cristatum ps exhibit high resist preval physiolog race stripe rust cyr cyr studi three diseas resist relat transcript map cristatum ps analysi specif molecular marker acquir among cristatum full length transcript bc f bc f genet popul transloc line wat analyz use three diseas resist relat gene marker cristatum p genom specif marker fluoresc situ hybrid fish result reveal introgress cristatum p genom wheat genom observ progeni genet popul transloc line wat physic posit three gene consider adjac cristatum ps accord fish result addit kompetit allel specif pcr kasp marker three gene develop detect acquir breed line select progeni distant hybrid wheat cristatum show resist physiolog race stripe rust cyr cyr desir agronom trait accord field investig conclus studi provid new insight introgress cristatum p genom wheat genom also provid desir germplasm breed practic | D018745 | T028 |
34,681,865 | parathyroid tumor molecular signatur parathyroid tumor rare endocrin neoplasm affect general popul includ benign parathyroid adenoma pas case intermedi atyp parathyroid adenoma apa case malign metastat parathyroid carcinoma pcs less case tumor character variabl spectrum clinic phenotyp elev cellular histolog molecular heterogen make difficult pre oper distinguish pas apa pcs thorough knowledg genet epigenet molecular signatur character differ parathyroid tumor subtyp drive differ tumorigenes key step identifi potenti diagnost biomark abl distinguish among differ parathyroid neoplast type well provid novel therapeut target strategi rare neoplasm still clinic therapeut challeng review current knowledg gene mutat epigenet chang associ develop differ clinic type parathyroid tumor famili sporad form endocrin neoplasm | D009154 | T045 |
34,681,864 | noncod rna mediat regul respons macronutri stress plant macronutri element includ nitrogen n phosphorus p potassium k calcium ca magnesium mg sulfur requir relat larg steadi amount plant growth develop defici excess suppli macronutri extern environ may trigger seri plant respons phenotyp molecular level entir life cycl among intertwin molecular network under plant respons macronutri stress noncod rnas ncrnas main microrna mirna long ncrnas lncrnas may serv pivot regul coordin nutrient suppli plant demand respons ncrna target modul interact mechan vari among element speci toward comprehens identif function character nutrient respons ncrnas downstream molecul high throughput sequenc produc massiv omic data compar express profil first step review highlight recent find ncrna mediat regul respons macronutri stress special emphasi larg scale sequenc effort screen candid nutrient respons ncrnas plant discuss potenti improv theoret studi provid better guidanc crop breed practic | D018749;D022661 | T114 |
34,681,860 | potenti melt electrowritten scaffold seed meniscus cell mesenchym stromal cell meniscus injuri meniscectomi strong relat osteoarthr thus clinic need meniscus replac purpos studi creat meniscus scaffold micro scale circumferenti radial fibr suitabl one stage cell base treatment poli caprolacton base scaffold three differ architectur made use melt electrowrit mew technolog vitro perform compar scaffold made use fuse deposit model fdm clinic use collagen meniscus implant cmi scaffold seed meniscus mesenchym stromal cell mscs fibrin gel cultur basal level proteoglycan product demonstr mew scaffold cmi fibrin gel control yet within fdm scaffold less proteoglycan product observ compress properti assess uniaxi confin compress cultur mew scaffold show higher young modulus compar cmi scaffold higher yield point compar fdm scaffold studi demonstr feasibl creat wedg shape meniscus scaffold mew use medic grade materi seed scaffold clinic feasibl cell number type potenti translat one stage treatment | D059630 | T025 |
34,681,855 | engin pyrrolysyl trna synthetas incorpor non canon amino acid smaller side chain site specif incorpor non canon amino acid ncaa protein emerg univers tool system bioengin interfac chemistri biolog technolog diversif repertoir genet code achiev amino acid long andor bulki side chain equip various bioorthogon tag use spectral probe although ncaa relat small side chain similar properti great interest biophys cell biolog biomateri scienc rare incorpor protein address gap report engin pylr variant capabl incorpor entir librari aliphat small tag ncaa particular perform mutat studi specif pylr design incorpor shortest non bulki ncaa allyl l cystein possibl date base knowledg incorpor aliphat ncaa deriv way increas number translate activ small tag ncaa also determin key residu respons maintain orthogon engin pylr interest substrat base known plastic pylr toward differ substrat approach expand reassign capac enzym toward aliphat amino acid smaller side chain endow valuabl function | D005815;D015202 | T085;T063 |
34,681,854 | lncrnas regul gene signal pathway mirna mediat mechan clear cell renal cell carcinoma fundament novelti pathogenesi renal cell carcinoma rcc discov result recent identif role long non code rnas lncrnas discuss sever mechan dysregul express protein code gene initi lncrnas common aggress type kidney cancer clear cell rcc ccrcc model competit endogen rna cerna consid lncrna act gene lncrnamirnamrna axi studi oncogen lncrnas hotair malat tug sever regulatori axe identifi ccrcc demonstr number site various mirna interest lincmir siglec axi repres novel agent suppress immun respons patient ccrcc serv valuabl target addit pdpd l pathway mechan action lncrnas ccrcc involv direct bind protein mrnas genesdna also consid review briefli highlight method various mechan action lncrnas verifi pay special attent protein target signal pathway lncrnas associ ccrcc thus new data differ mechan lncrna function provid novel basi understand pathogenesi ccrcc identif new prognost marker target therapi | D015972;D015398 | T043;T044;T045 |
34,681,853 | atyp renal clearanc nanoparticl larger kidney filtrat threshold recent year sever public report nanoparticl larger kidney filtrat threshold found intact urin inject laboratori mice theoret possibl wide known kidney prevent molecul larger nm escap urin interest impli nanoparticl overcom size limit renal clearanc kind nanoparticl bypass glomerular filtrat barrier cross urin physic chemic characterist essenti nanoparticl abil biomolecular cellular mechan involv review attempt answer question summar known report renal clearabl larg nanoparticl | D060730;D053758 | T042;T073 |
34,681,852 | transcriptom coexpress network analys reveal pine chalcon synthas gene associ pine wood nematod infect pine wood nematod pwn caus serious diseas conif especi pine speci investig transcriptom profil gene involv pine pwn interact two differ pine speci name pinus thunbergii p massoniana select studi weight gene coexpress network analysi wgcna use determin relationship chang gene express pwn popul pwn infect pwn infect negat affect express gene pine tree includ plant defens relat gene gene relat plant hormon signal transduct plant pathogen interact mapk signal pathway plant howev express chalcon synthas gene relat gene proport chang nematod popul chalcon synthas gene domin within coexpress modul enrich gene high correl nematod popul mani gene close relat chalcon synthas gene modul relat flavonoid biosynthesi flavon flavonol biosynthesi phenylpropanoid biosynthesi pine tree could activ adjust defens strategi respons chang number invas pwns sustain express chalcon synthas gene play import role inhibit pwn infect | D017168 | T204 |
34,681,850 | head head comparison fibroblast activ protein inhibitor fapi radiotrac versus f f fdg oncolog systemat review sever recent studi compar radiolabel fibroblast activ protein inhibitor fapi fluorin fluorodeoxyglucos f f fdg positron emiss tomographi pet radiotrac oncolog publish aim systemat review perform updat evid base summari comparison pet radiotrac oncolog better address research set studi subset studi compar radiolabel fapi f f fdg pet radiotrac oncolog elig inclus systemat review systemat literatur search pubmedmedlin cochran librari databas perform august literatur data comparison f f fdg radiolabel fapi rapid increas overal take account radiotrac uptak tumor background uptak ratio compar f f fdg pet equal higher detect primari tumor andor metastat lesion usual demonstr use radiolabel fapi pet particular cancer entiti better detect rate tumor lesion use radiolabel fapi pet compar f f fdg pet gastrointestin tumor liver tumor breast cancer nasopharyng carcinoma comparison studi need better evalu best field applic radiolabel fapi pet | D019788 | T130;T109 |
34,681,849 | tendon specif doubl report transgen mous enabl track cell lineag function alter vitro vivo generat character transgen mous line tendon specif express doubl fluoresc report system fulfil unmet need anim model support real time monitor cell behavior tendon develop growth repair vitro vivo mscarlet red fluoresc protein driven scleraxi scx promot report cell lineag alter blue fluoresc protein report express control kb collagen type alpha chain cola proxim promot promot exist two promot region name tendon specif cis act element tse tse ensur specif express blue fluoresc protein bfp tendon tissu collagen crucial marker tendon regener major compon healthi tendon thus alter function tendon repair estim bfp express mechan stimul express mscarlet bfp increas adipos deriv mesenchym stem cell admsc transgen mous line rise trend tendon key marker result suggest tendon specif doubl report system novel model use studi cell differenti extracellular matrix alter vitro vivo | D008822;D011401 | T015;T114;T123 |
34,681,848 | adipos deriv stemstrom cell kidney transplant status quo futur perspect kidney transplant kt gold standard treatment end stage renal diseas despit progress advanc organ preserv surgic techniqu intens care immunosuppress long term allograft surviv signific improv among mani peri oper complic jeopard transplant outcom ischemia reperfus injuri iri deserv special consider associ delay graft function acut reject prematur transplant loss year sever strategi propos mitig impact iri favor toler rather disappoint result mount evid adipos stemstrom cell asc possess specif characterist could help prevent reduc revers iri immunomodul tolerogen properti also suggest thus lead develop asc base prophylact therapeut strategi pre clinic clinic model renal iri allograft reject asc copious easi harvest readili expand cultur furthermor asc secret extracellular vesicl ev may act power mediat tissu repair toler present review discuss current knowledg mechan action therapeut opportun offer asc asc deriv ev kt set relev pre clinic clinic studi well actual limit futur perspect highlight | D016030 | T061 |
34,681,845 | screen adrenerg receptor modul advanc pharmacoinformat machin learn approach cardiovascular diseas cds major concern human race one lead caus death worldwid adrenerg receptor ar ar play crucial role overal regul cardiac function present studi structur base virtual screen machin learn ml ligand base similar search conduct pubchem databas ar initi dock molecul screen use threshold bind energi valu molecul better bind affin use segreg activ inact ml pharmacokinet assess carri molecul retain step similar search chembl drugbank databas perform detail analysi data four compound ar found promis natur number critic ligand bind amino acid form potenti hydrogen bond hydrophob interact final molecular dynam md simul studi molecul bound respect target perform number paramet obtain md simul trajectori calcul substanti stabil protein ligand complex henc postul final molecul might crucial cds subject experiment valid | D055808;D056004 | T044;T062;T066 |
34,681,843 | induct endoplasm reticulum stress mediat apoptosi aminosteroid rm effici block growth pc cancer cell tumor resist docetaxel aminosteroid deriv rm previous identifi endoplasm reticulum er stress induc potent vitro vivo anticanc activ report evalu androgen independ prostat cancer pc cell rm effici block pc cell prolifer stronger activ select known antineoplast agent later also show synergist effect docetaxel abl block prolifer docetaxel resist pc cell contrari docetaxel induc cell resist rm induc increas express level er stress relat marker apoptosi potenti trigger presenc rm er pc cell vitro result success translat vivo pc xenograft tumor model nude mice show superior blockad docetaxel rm also abl stop progress pc cell becom resist docetaxel treatment concomit observ decreas gene marker mevalon fatti acid pathway intratumor level cholesterol fatti acid overal work demonstr potenti er stress induc anticanc agent treatment prostat cancer refractori common use chemotherapi treatment | D017209;D059865 | T043;T116;T049;T123 |
34,681,842 | applic mesenchym stem cell target deliveri brain potenti challeng extracellular vesicl base approach brain tumor treatment treat brain tumor present enorm challeng still poor prognos adult children applic novel target potenti drug hinder function blood brain barrier signific restrict therapeut access tumor mesenchym stem cell mscs cross biolog barrier migrat site injuri exert mani heal effect engin incorpor differ type cargo make ideal vehicl transport anti tumor agent central nervous system extracellular vesicl ev produc mscs msc ev valuabl innat properti parent cell exploit cell free treatment mani neurolog diseas compar use mscs target deliveri via msc ev better pharmacokinet profil yet avoid mani critic issu cell base system field msc therapeut applic quick expand articl aim give overal pictur one direct ev base target brain tumor updat avail techniqu outcom experiment model critic challeng concept | D001812;D001921;D000067128;D018014;D059630 | T023;T026;T025;T062;T063 |
34,681,841 | discoveri chromosom locat high effect oat crown rust resist gene pc crown rust caus puccinia coronata f sp avena one destruct fungal diseas oat worldwid grow diseas resist oat cultivar prefer method prevent spread rust potenti epidem object studi pc race specif seedl crown rust resist gene high effect growth stage select differenti line pc avena sterili l cw pendek comparison crown rust reaction well allel test show distinct pc wherea proport phenotyp segreg popul deriv cross two crown rust suscept polish oat cultivar kasztan pc bingo pc confirm monogen inherit gene indic use oat breed program effect gene introgress depend reliabl gene identif earli stage plant develop thus aim studi develop molecular marker tight link pc segreg popul kasztan pc genotyp use dart seq technolog base next generat illumina short read sequenc marker associ pc locat chromosom current version oat refer genom avena sativa ot v pepsico region bp subsequ convert pcr base scar sequenc character amplifi region marker furthermor scar scar co segreg pc resist allel map partial linkag group cm respect co domin scar marker best diagnost locat closest pc cm newli discov strong monogen crown rust resist may use oat improv dart seq sequenc convert specif pcr marker valuabl tool marker assist select breed program | D017343;D005819;D000084643 | T049;T045;T004;T028;T086 |
34,681,836 | inhibit spinal trpv reduc nmda receptor b phosphoryl produc anti nocicept effect mice inflammatori pain transient receptor potenti vanilloid trpv implic peripher inflamm mediat inflammatori respons various noxious stimuli howev interact trpv n methyl aspart nmda receptor regul inflammatori pain remain poor understood studi aim investig analges effect intrathec administr capsazepin trpv antagonist carrageenan induc inflammatori pain mice identifi interact nmda receptor inflammatori pain induc intraplantar inject carrageenan male icr mice investig analges effect capsazepin pain relat behavior evalu use von frey filament thermal stimul place hind paw trpv express nmda receptor phosphoryl spinal cord glutam concentr spinal cord serum measur intrathec treatment capsazepin signific attenu carrageenan induc mechan allodynia thermal hyperalgesia moreov carrageenan enhanc glutam phosphoryl nmda receptor subunit b spinal cord suppress capsazepin administr result indic trpv nmda receptor spinal cord associ inflammatori pain transmiss inhibit trpv may reduc inflammatori pain via nmda receptor | D007249 | T046 |
34,681,835 | saa enhanc immunomodulatori tissu repair properti human amniot mesenchym stem cell myocardi ischemia reperfus injuri paracrin factor human mesenchym stem cell hmscs potenti prevent advers cardiac remodel myocardi infarct mi sa sa calcium bind protein play essenti role regul inflamm fibrous tissu format might modul paracrin effect hmscs isol human amniot mesenchym stem cell hamsc examin chang express level regulatori gene inflamm fibrosi hamsc treat saa anti inflammatori anti fibrot effect hamsc pretreat saa shown superior hamsc without saa pretreat cardiomyocyt hypoxiareoxygen experi establish murin myocardi ischemiareperfus model compar therapeut effect condit medium hamsc without saa pretreat found heart administ condit medium hamsc saa pretreat better left ventricular systol function day mi result suggest saa enhanc paracrin therapeut effect hamsc aspect anti inflamm anti fibrosi cardiac function preserv mi | D056747 | T061 |
34,681,834 | role selenoprotein ethanolamin phospholipid synthesi cell activ selenoprotein famili includ member mani antioxid redox regul enzym uniqu member famili selenoprotein selenoi catalyz redox reaction instead ethanolamin phosphotransferas ept fact characterist selenocystein residu defin selenoprotein lie far outsid catalyt domain selenoi furthermor data use recombin selenoi lack selenocystein residu suggest selenocystein amino acid direct involv ept reaction selenoi involv two differ pathway synthesi phosphatidylethanolamin pe plasmenyl pe constitu cellular membran ethanolamin phospholipid synthesi emerg import process metabol reprogram occur pluripot stem cell prolifer tumor cell review discuss role upregul selenoi cell activ prolifer differenti selenoi defici lower complet diminish de novo synthesi pe plasmenyl pe cell activ interest metabol reprogram activ selenoi defici cell impair reduc prolif capac favor tolerogen pathogen phenotyp aris differenti implic find discuss relat vaccin respons autoimmun cell base therapeut approach | D008213 | T043 |
34,681,833 | host defens peptid dual antimicrobi immunomodulatori action rapid rise multidrug resist mdr bacteria caus bacteri infect becom global health concern antimicrobi peptid amp also known host defens peptid hdps offer viabl solut pathogen due divers mechan action includ direct kill well immunomodulatori properti eg anti inflammatori activ hdps may henc provid robust treatment bacteri infect review advent mechan lead antibiot resist describ hdp mechan antibacteri immunomodulatori action present specif exampl hdp aurein deriv name peptid cgl function final resist may aris broader use hdps clinic set method improv biocompat briefli discuss | D056747 | T061 |
34,681,832 | glucocorticoid receptor signal diabet stress depress increas risk type diabet td develop evid demonstr glucocorticoid gc negat feedback impair gc resist td patient result hypothalam pituitari adren hpa axi hyperact hypercortisol high gcs turn activ multipl aspect glucos homeostasi peripher tissu lead hyperglycemia elucid under molecular mechan reveal glucocorticoid receptor gr mediat gc induc dysregul glucos product uptak insulin signal gc sensit peripher tissu liver skelet muscl adipos tissu pancrea contrast increas gr peripher sensit impair gr signal peripher blood mononuclear cell pbmcs td patient associ hyperglycemia hyperlipidemia increas inflamm shown given gr chang immun cell parallel brain data implic reduc brain gr function may biolog link among stress hpa hyperact hypercortisol hyperglycemia gr polymorph also associ metabol disturb td dysregul micro rnas known target gr mrna describ collect gr crucial role td act cell type context specif manner lead either gc sensit gc resist select modul gr signal td therapi warrant investig | D011110;D015398 | T043;T044;T045 |
34,681,831 | supplement lactiplantibacillus plantarum imc modifi microbiota composit prevent bodi weight gain induc cafeteria diet rat chang function composit gut microbiota gm associ may contribut develop mainten obes relat diseas aim studi investig first time impact lactiplantibacillus l plantarum imc rat model diet induc obes specif cafeteria caf diet diet provid strong motiv voluntari overeat due palat varieti select energi dens food oral administr day probiot strain ad caf diet decreas food intak bodi weight gain accord amelior bodi mass index liver white adipos tissu weight hepat lipid accumul adipocyt size serum paramet includ glycemia low densiti lipoprotein level caf fed rat potenti leptin control scenario l plantarum imc show also benefici effect gm limit microbi imbal establish long exposur caf diet preserv proport differ bacteri taxa research necessari better elucid relationship gm overweight mechan action l plantarum imc modifi weight howev promis result prompt clear advantag probiot supplement identifi new potenti probiot novel safe therapeut approach obes prevent manag | D044822 | T080 |
34,681,829 | extracellular environ control angiogenesi potenti applic peripher nerv regener endotheli cell acquir differ phenotyp establish function vascular network vascular endotheli growth factor vegf signal induc endotheli prolifer migrat surviv regul vascular develop lead construct vascular plexus regular morpholog spatiotempor local angiogen factor extracellular matrix play fundament role ensur proper regul angiogenesi review articl highlight kind extracellular environment molecul regul angiogenesi close interact vascular neural system involv share molecular mechan coordin development regen process review articl focus current knowledg role angiogenesi peripher nerv regener latest therapeut strategi treatment peripher nerv injuri | D018919;D009416;D015398 | T043;T044;T039;T042 |
34,681,827 | poli amidoamin dendrim nanocarri fluorouracil effect complex format cytotox studi two generat posit charg poli amidoamin dendrim pamam select studi potenti carrier anticanc drug fluorouracil fu drug primarili use treatment colorect cancer analyt techniqu uv vis spectrophotometri nmr spectroscopi laser doppler velocimetri ldv shown critic factor determin format pamam fu complex start compon proton degre test confirm system abil attach fu molecul per one dendrim molecul gpamam dendrim molecul gpamam dendrim give system yield fourth generat sixth generat dendrim addit use qcm method adsorpt effici number drug molecul immobil dendrim structur determin new aspect studi determin chang zeta potenti induc immobil fu molecul dendrim outer shell import effect direct contact carrier cell cytotox test resazurin reduct mts test show toxic dendrim mous fibroblast cell l signific decreas cell viabil case four human malign cell line malign melanoma glioblastoma snb prostat cancer du colon adenocarcinoma ht incub pamam fu complex purpos work investig correl physicochem properti carrier activ substanc system effici optim condit format effici system base pamam dendrim nanocarri fluorouracil addit aspect identifi potenti applic properti complex demonstr cytotox test | D055598 | T070 |
34,681,826 | review discoveri profil piwi interact rnas divers function metazoan piwi interact rnas pirna class small non code rnas sncrnas perform crucial biolog function metazoan defend transpos element tes germ line recent ubiquit express pirna discov soma germ line use small rna sequenc srna seq human anim provid new insight divers function pirna howev role pirna yet fulli elucid srna seq studi continu reveal differ pirna activ genom review summar set simplifi process pirna analysi order provid use guid research perform pirna research suitabl studi object process help expand function research pirna previous report srna seq result metazoan ubiquit express pirna discov soma germ line annelida cnidaria echinodermata crustacea arthropoda mollusca limit germ line chordata role pirna te silenc gene express regul epigenet regul embryon develop immun respons associ diseas continu discov via srna seq | D004251;D044127;D005786 | T086;T114;T045;T123 |
34,681,825 | encapsul plant biocontrol bacteria algin main polym materi one favor trend modern agricultur biolog control howev mani report show surviv biocontrol bacteria poor host plant provid biocontrol agent protect encapsul within extern coat therefor becom popular idea various techniqu includ extrus spray dri emuls introduc encapsul biocontrol bacteria one common use biopolym type microencapsul algin biopolym extract seawe recent progress result product algin base microcapsul meet key bacteri encapsul requir includ biocompat biodegrad support long term surviv function howev studi need regard effect encapsul protect bacteria target releas organ crop product system import efficaci algin use encapsul biocontrol bacteria pest diseas manag requir verif achiev new formul base biodegrad polym signific effect increas quantiti qualiti agricultur product | D061046 | T123 |
34,681,824 | ppr protein requir chloroplast rna edit splice chloroplast develop maiz chloroplast play essenti role plant growth develop factor affect chloroplast develop lead abnorm plant growth character new maiz mutant albino seedl mutant exhibit entir albino phenotyp leav eventu die three leaf stage transmiss electron microscopi tem demonstr chloroplast thylakoid membran impair granum lamella signific decreas map base clone transgen analysi confirm ppr encod new chloroplast protein consist pentratricopeptid repeat domain quantit real time pcr qrt pcr assay transcriptom analysi rna seq show ppr mutat signific disrupt express pep depend plastid gene addit rna splice rna edit multipl chloroplast gene show sever defect result indic ppr crucial rna edit rna splice chloroplast gene play essenti role chloroplast develop | D017393;D012326 | T045 |
34,681,823 | cellular protein phosphatas regul cell surviv mechan influenza virus infect influenza virus iav respiratori pathogen abl hijack multipl cellular mechan drive replic consequ sever viral cellular protein undergo posttransl modif dynam phosphorylationdephosphoryl eukaryot cell dephosphoryl main catalyz protein phosphatas ppa function kinas iav infect quit well studi littl known role ppa iav replic show use knockdown inhibit approach catalyt subunit ppac phosphatas import effici replic sever iav subtyp could neither attribut alter antivir immun respons chang transcript translat viral gene interest decreas ppac level result signific reduc cell viabil iav infect comprehens kinas activ profil identifi enrich process network relat apoptosi indic synergist action hyper activ pikakt mapkjak stat nf kb signal pathway collect result increas cell death taken togeth iav seem effect tap leftov ppa activ ensur effici viral replic reduc ppac level fail orchestr cell surviv mechan protect infect cell earli cell death | D017209;D002470 | T043;T116;T123 |
34,681,821 | phytoconstitu bioactiv plant genus spiraea l rosacea review genus spiraea l belong rosacea juss famili includ speci distribut temper zone subtrop zone northern hemispher center speci divers east asia repres genus known ornament plant mani form varieti wide use convent medicin high resourc potenti review provid inform divers phenol compound flavonoid phenolcarboxyl acid lignan terpenoid alkaloid steroid class secondari metabolit speci spiraea worldwid articl also present littl known hard find data publish russian concern spiraea phytochemistri biolog activ extract fraction individu compound differ type biolog activ eg antioxid antibacteri anti inflammatori antifung discuss data biotechnolog research repres genus spiraea present analysi literatur show chemic pharmacolog studi spiraea plant quit promis | D008519 | T091;T058;T061 |
34,681,819 | open question non ioniz radiat tool control apoptosi induc prolifer non ioniz radiat common use clinic set despit known abil trigger oxid stress apoptosi lead damag cell death although induct cell death typic consid harm apoptosi also benefici right context exampl cell death serv signal new tissu growth apoptosi induc prolifer recent data shown exposur non ioniz radiat weak static magnet field weak radiofrequ magnet field weak electromagnet field abl modul prolifer cell cultur live organ exampl tissu regener occur via vivo chang level reactiv oxygen speci ros canon activ apoptosi review describ literatur highlight tantal possibl non ioniz radiat could use manipul apoptosi induc prolifer either promot growth regen medicin inhibit cancer therapi howev uncontrol growth lead tumorigenesi much research excit develop area need order realiz promis | D011840 | T070 |
34,681,818 | hpv lesion issu oral caviti treatment remov without pain due differ oral dental condit oral mucosa lesion caus human papilloma virus temporomandibular joint patholog often treat surgic ablat extract procedur treatment control pain inflamm procedur essenti guarante patient well forego reason hydrogel base sodium algin hyaluron acid contain ketorolac tromethamin develop character physic mechan morpholog rheolog result suggest formul easili gentl appli ex vivo permeat studi show ketorolac tromethamin abl penetr buccal sublingu mucosa addit retain mucosa structur vitro test abl evalu role saliva play bioavail drug observ half appli dose elimin hour histolog cytotox studi perform pig vivo show excel safeti profil formul well high toler parallel biomimet artifici membran permeapad evalu show high degre correl oral sublingu mucosa | D000084342;D027383 | T169;T005 |
34,681,803 | structur base function analysi hormon belong ecdysozoan peptid superfamili revel common molecular architectur residu possibl receptor interact neuropeptid sco chh l belong crustacean hyperglycem hormon chh superfamili preferenti express pericardi organ pos mud crab scylla olivacea function structur studi express level signific higher altern splice form sco chh pos increas signific anim subject hypo osmot stress sco chh l sco chh signific stimul vitro na k atpas activ posterior th gill furthermor solut structur sco chh l resolv use nuclear magnet reson spectroscopi reveal n termin tail three helic gli asn gli glu arg helix cys tyr structur constrain pattern disulfid bond cys cys cys cys cys cys characterist chh superfamili peptid sco chh l topolog similar molt inhibit hormon kuruma prawn marsupenaeus japonicus backbon root mean squar deviat ten residu sco chh l chosen alanin substitut result mutant function test use gill na k atpas activ assay show function import residu f e g locat either end sequenc steric close presum constitut receptor bind site sco chh l compar member superfamili reveal fold pattern suggest common crustacean member superfamili properti residu constitut presum receptor bind site major factor dictat ligand receptor bind specif | D060829;D003386;D007447;D009419;D009479 | T123;T204;T116;T125 |
34,681,801 | transcriptom analys reveal famili member cytochrom p cyp involv lps inflammatori respons pharynx ciona robusta cytochrom p cyp enzym respons biotransform endogen exogen agent express cyp influenc uniqu combin mechan factor includ genet polymorph induct xenobiot regul cytokin hormon recent year ciona robusta one closest live relat vertebr becom model various field biolog particular studi inflammatori respons use vivo lps exposur strategi next generat sequenc ngs qrt pcr combin bioinformat silico analys compar whole pharynx transcript nave lps expos c robusta provid first view cytochrom gene express mirna regul inflammatori respons induc lps hematopoiet organ c robusta cytochrom belong bc j u b f subfamili deregul mirna network interact suggest differ conserv speci specif mirna involv post transcript regul cytochrom gene could interplay specif mirna regul inflamm cytochrom molecul inflammatori respons c robusta | D002938;D003577 | T204;T116;T126 |
34,681,800 | mitochondri plastid genom monoraphid diatom schizostauron trachyderma provid first time complet plastid mitochondri genom monoraphid diatom schizostauron trachyderma mitogenom bp size display two group ii intron cox gene bp plastid genom featur typic quadripartit architectur diatom genom contain group ii intron petb gene overlap larg singl copi invert repeat region also group ib intron encod putat laglidadg home endonucleas rnl gene multigen phylogeni conduct provid evid proxim trachyderma fistula bear speci biraphid diatom | D054629;D054627 | T028 |
34,681,795 | conserv structur evolut dpf domain phf specif subunit pbaf chromatin remodel complex transcript activ factor multisubunit coactiv complex get recruit specif chromatin site via protein domain recogn histon modif singl phds plant homeodomain interact differenti modifi h histon tail doubl phd finger dpf domain possess uniqu structur differ phd found six protein histon acetyltransferas moz morf chromatin remodel complex baf dpf chromatin remodel complex pbaf phf among phf stand due dpf sequenc structur function phf ubiquit express develop adult organ four isoform differ structur presenc absenc dpf transcript regul function despit import dpf domain phf transcript activ structur remain undetermin perform homolog model human phf dpf domain determin common distinct featur structur histon modif recognit capabl affect pbaf complex chromatin recruit also trace evolut dpf phf gene unicellular vertebr organ data review suggest dpf domain phf play import role swisnf depend chromatin remodel transcript activ | D018398;D009363 | T116;T123 |
34,681,794 | develop novel quinolin base sulfonamid select cancer associ carbon anhydras isoform ix inhibitor new seri quinolin base benzenesulfonamid qbs develop potenti carbon anhydras inhibitor cai target qbs cai base anilinoquinolin scaffold primari sulphonamid function graft c anilino moieti zinc anchor group qbs nbsp c thereaft sulphonamid group switch ortho meta posit afford regioisom g moreov linker elong approach adopt amino linker replac hydrazid one afford qbs nbsp describ qbs synthes investig ca inhibitori action h ca ii ix xii general para sulphonamid deriv c display best inhibitori activ cancer relat isoform h ca ix k nm respect h ca xii k nm respect besid excel h ca ix inhibitori activ exert meta sulphonamid deriv c k nm promis qbs evalu anticanc pro apoptot activ two cancer cell line mda mb mcf addit molecular dock simul studi appli justifi acquir ca inhibitori action target qbs | D002257;D011804;D013449 | T121;T109 |
34,681,793 | mir b p master regul potenti biomark breast cancer aggress prognosi breast cancer bca lead caus death cancer women worldwid diseas main stratifi four subtyp accord presenc specif receptor import bca aggress progress prognosi microrna mirna small non code rnas capabl modul sever gene aim identifi mirna signatur deregul preclin clinic bca model potenti biomark discoveri would use bca diagnosi andor prognosi identifi hsa mir p mir b p regul hsa mir p mir p regul bca compar normal breast normal adjac nat tissu establish share target gene hsa mir p mir b p negat correl mirna express furthermor assess pathway gene involv select associ cancer metabol addit gab gng hbp mefa pafahb ppprb rpska sesn downregul bca compar nat interest hsa mir b p regul gab gng hbp sesn downregul aggress subtyp final patient high level hsa mir b low level abovement gene wors relaps free surviv wors overal surviv except gab | D001943 | T191 |
34,681,792 | cscdpk cssam interact protein affect polyamineethylen biosynthesi cucumb enhanc salt toler overexpress tobacco adenosylmethionin synthetas sam play crucial role regul stress respons recent studi found overexpress cucumb gene cssam tobacco affect product polyamin ethylen well enhanc salt stress toler tobacco exact under mechan elus calcium depend protein kinas cdpk famili ubiquit plant perform differ biolog function plant develop respons abiot stress use yeast two hybrid system detect whether protein cdpk could interact sam verifi interact bimolecular fluoresc complement bifc co immunoprecipit co ip assay explor function cucumb cdpk isol character cscdpk cucumb cscdpk membran protein high express various abiot stress includ salt stress also observ ectop overexpress cscdpk tobacco enhanc salt toler salt stress cscdpk overexpress line enhanc surviv rate reduc stomat apertur comparison wild type wt line well lower malondialdehyd mda hydrogen peroxid h content caus less relat electrolyt leakag moreov repress cscdpk express virus induc gene silenc vig cucumb seedl cotyledon salt stress increas ethylen product promot transform putrescin put spermidin spd spermin spm find shed light interact cssam cscdpk function posit regul salt stress plant | D018553;D014026 | T002;T168 |
34,681,790 | extend chees whey ferment produc novel casein deriv antibacteri polypeptid also inhibit gelatinas mmp mmp previous work produc whey ferment methodolog yield antibacteri activ potenti inhibit matrix metalloproteas mmp evalu activ due ferment produc peptid prolong ferment carri presenc specif lactic acid bacteria lab consortium lab ferment yield total polypeptid predomin produc day ferment one deriv beat casein present particular high antibacteri activ food pathogen bacteria effect standard food disinfect polypeptid studi also found activ sever strain pathogen bacteria includ methicillin resist staphylococcus aureus mrsa dose depend manner also inhibit mmp mmp whilst reduc ht cancer cell migrat vitro overal novel whey deriv polypeptid present dual antibacteri anti inflammatori activ reveal strong potenti use function food nutraceut identif character open novel perspect field preventivecur diet relat gut microbiota gut inflamm cancer prevent particular use vivo studi | D002611 | T168 |
34,681,786 | inhibit glutam releas glutamin recycl glutam involv delay onset initi lithium pilocarpin induc seizur young rat non convuls mso dose initi seizur observ young rat min administr pilocarpin pilo delay attenu pretreat non convuls dose methionin sulfoximin mso hypothes effect mso result glutamin synthetas block mediat inhibit convers glugln precursor neurotransmitt glu andor b alter synapt glu releas pilo administ min prior sacrific mso mgkg ip h earlier c acet u c glucos ip inject either togeth pilo short period min sacrific long period convers glu gln hippocampus entorhin cortex follow use c gas chromatographi mass spectrometri releas vitro load glu surrog h asp ex vivo brain slice monitor continu collect superfus h asp uptak test fresh isol brain slice time point brain region mso modifi incorpor c glu gln pilo treat rat mso pretreat decreas high potassium induc h asp releas affect h asp uptak result indic mso non convuls dose delay initi pilo induc seizur interf synapt glu releas neurotransmitt glu recycl | D012640 | T047;T184;T046 |
34,681,782 | effect methyl jasmon thymol carvacrol phytochem accumul express key gene involv thymolcarvacrol biosynthet pathway iranian thyme speci thyme speci good sourc thymol carvacrol play key role control diseas first time express pattern terpinen synthas tps cypd cypd gene amount phenol compound evalu migricus daenensi differ methyl jasmon meja treatment highest thymol carvacrol content observ migricus daenensi meja consist express pattern three investig gene speci treat show high total phenol flavonoid content compar control plant highest amount observ vulgari treat meja furthermor meja treatment relat express tps cypd migricus increas fold compar control respect highest level cypd transcript fold also observ daenensi treat find highlight notion thymol known domin compon essenti oil rather carvacrol diffid thyme speci impli meja differ concentr influenc metabol pathway induc express chang result rise essenti oil level | D064209;D046930 | T002;T168;T109;T123 |
34,681,780 | bsa hydrogel bead function specif aptam librari captur pseudomona aeruginosa serum blood system blood stream infect major threat human health dramat increas worldwid pseudomona aeruginosa alert multi resist pathogen extrem import caus sepsi septicemia patient signific increas surviv chanc sepsi diagnos earli stage affin materi repres attract tool specif diagnost pathogen blood prospect also serv technic foundat therapeut filtrat devic base recent develop aptam direct p aeruginosa present aptam function bead specif bind pathogen blood sampl aptam captur bead acb manufactur crosslink bovin serum albumin bsa emuls subsequ function amino modifi aptam bead surfac use thiol amino reactiv bispecif crosslink peg spdp specif quantit bind p aeruginosa dedic target acb demonstr serum blood initi promis result may open new rout develop acb platform technolog fast reliabl diagnosi bloodstream infect long term blood filtrat techniqu fight sepsi | D052157;D015723 | T028;T114 |
34,681,779 | biomark immunotherapi sclc small cell lung cancer sclc aggress malign exhibit rapid doubl time high growth fraction earli develop widespread metastas addit immun checkpoint inhibitor first line chemotherapi repres first signific improv system therapi sever decad howev contrast effect non sclc advantag effect immunotherapi addit modest sclc particular small number sclc patient benefit immun checkpoint inhibitor addit biomark select lack sclc clinic trial larg focus unselect popul review data concern major biomark immunotherapi name program death ligand express tumour mutat burden furthermor explor potenti biomark includ role immun microenviron sclc role genet alter potenti link neurolog paraneoplast syndrom serum anti neuron nuclear antibodi outcom sclc patient treat immunotherapi | D007167 | T061 |
34,681,776 | light induc regul pathway anthocyanin biosynthesi plant anthocyanin natur pigment antioxid effect exist various fruit veget accumul anthocyanin induc environment signal regul transcript factor plant numer evid indic among environment factor light one signal regulatori factor involv anthocyanin biosynthesi pathway howev signal transduct light molecular regul anthocyanin synthesi remain explor focus research progress signal transduct factor posit negat regul light depend light independ anthocyanin biosynthesi particular discuss light induc regulatori pathway relat specif regul anthocyanin biosynthesi plant addit integr regulatori network anthocyanin biosynthesi control transcript factor discuss base signific progress | D008027 | T070 |
34,681,773 | contribut metabolom multipl sclerosi diagnosi prognosi treatment metabolom base technolog map vivo biochem chang may use earli indic patholog abnorm prior develop clinic symptom neurolog condit metabolom may also reveal biochem pathway implic tissu dysfunct damag thus assist develop novel target therapeut neuroinflamm neurodegener metabolom hold promis non invas high throughput cost effect tool earli diagnosi follow monitor treatment respons multipl sclerosi ms combin clinic imag measur review offer evid support potenti metabolom biomark drug discoveri tool ms also use pathway analysi metabolit describ potenti biomark literatur ms biofluid identifi promis molecul upstream regul show novel still unexplor metabol pathway whose investig may open novel avenu research | D055432 | T091 |
34,681,763 | distinct evolutionari profil function microrna microrna land plant microrna mir mir high sequenc similar recogn overlap site target gene squamosa promot bind protein like spl sbp box gene make difficult accur distinguish role regulatori network affect numer biolog function collect data mir mir famili member repres land plant perform sequenc comparison phylogenet analysi small rna sequenc parallel analysi rna end pare analysi dissect evolutionari function differ although mir mir high similar differ mismatch sensit region essenti target recognit land plant mir precursor conserv main within hairpin region wherea mir precursor conserv outsid hairpin region includ arm phylogenet analysi show mir mir evolv independ diverg evolutionari pattern two gene also exhibit differ express pattern mir preferenti express reproduct tissu mir tissu pare analysi reveal mir mir possess specif target addit common target maiz point function differ base find develop method rapid identif mir mir famili member uncov evolutionari diverg famili provid insight differ regulatori role plant growth develop | D018506 | T045 |
34,681,762 | anti kasha behavior hydroxyflavon deriv excit state intramolecular proton transfer esipt hydroxyflavon hf known depend excit wavelength behavior violat kasha rule state emiss photochemistri compound would take place lowest excit state photochemistri hf studi use femtosecond transient absorpt spectroscopi shorter wavelength excit nm new experiment find interpret aid comput studi new result compar previous studi obtain longer wavelength excit show exist pathway proton transfer bypass normal first excit state higher excit state tautom first excit state experiment data correl electron densiti differ calcul proton transfer process faster longer excit wavelength compar shorter excit wavelength | D055668 | T070 |
34,681,749 | hydro electro hybrid prime promot carrot daucus carota l seed germin activ lipid util respiratori metabol carrot daucus carota l wide cultiv one import root crop develop effect presow treatment method promot develop modern mechan precis sow present studi novel seed prime technolog name hydro electro hybrid prime hehp use promot germin carrot seed seed germin experi show hehp abl increas germin index gi vigor index vi fold fold respect effect signific superior hydro prime hyd electrostat field treatment ef consumpt util rate seed storag reserv also great improv meanwhil glyoxysom mitochondria found appear ahead time endosperm cell hehp observ subcellular structur endosperm activ isocitr lyas icl nad depend malat dehydrogenas mdh pyruv kinas pk alcohol dehydrogenas adh signific increas hehp transcriptom result kyoto encyclopedia gene genom kegg pathway relat glyoxyl cycl glycolysi gluconeogenesi citrat cycl signific enrich real time quantit pcr qrt pcr analysi confirm express pattern critic differenti express gene deg pathway deg encod mdh phosphoenolpyruv carboxykinas pepck pk upregul hehp thus reason infer transform malat oxalacet phosphoenolpyruv pyruv cytoplasm may pivot energi suppli earli germin result suggest optim effect hehp achiev initi store lipid util respiratori metabol pathway relat germin | D050356 | T044 |
34,681,743 | nano sio silan coupl agent co decor graphen oxid enhanc anti corros perform epoxi composit coat coat great signific iron steel regard harsh marin environ graphen oxid go consid ideal filler materi epoxi coat howev undesir dispers epoxi togeth easi agglomer stack remain great problem practic applic go composit epoxi coat method effect solv self aggreg poor dispers go high desir herein present high dispers strategi graphen oxid epoxi co decor nano sio silan coupl agent co decor go fill epoxi coat exhibit high anti corros perform includ high electrochem imped high self corros potenti low self corros current superior electrochem imped stabil ten day q carbon steel work display new possibl design novel coat materi high perform toward practic marin anti corros applic | D003343 | T070 |
34,681,739 | futur stem cell deriv treatment glaucoma critic point view review focus clinic translat preclin studi especi use stem cell treatment glaucoma emphasi optic nerv regener studi refer review aim treat optic nerv atrophi cell therapi target site eye trabecular meshwork address complex vari pathophysiolog mechan lead glaucoma may explain fact although stem cell high capac neuron regener treatment perform expect result promis offer anim studi achiev analyz fact associ failur import lesson learn type stem cell use rout administr select patient elig treatment addit therapi support stem cell transplant mode action method avoid host immun respons mani problem could solv use exosom ev also mirna allow target approach minim side effect | D013234 | T025;T081 |
34,681,734 | genom studi novel virul phage vbsspskasia mu like prophag shewanella sp provid insight genet divers shewanella virom shewanella ubiquit bacteri genus aquat ecosystem bacteriophag also isol aquat environ ocean lake ice wastewat studi isol character novel virul shewanella phage vbsspskasia identif three prophag host shewanella sp includ mitomycin induc mu like siphovirus vbsspsmum becam start point compar analys phage infect shewanella spp determin posit among known bacteri virus similar network analysi reveal high divers shewanella phage general vbsspskasia cluster exclus colwellia phage form singl viral cluster compos two separ viral subclust furthermor vbsspsmum present signific differ phage deposit public databas expand divers known mu like phage give potenti molecular marker identif mu like prophag bacteri genom moreov function analysi perform vbsspskasia suggest despit kasia host strain grow better rich medium c phage replic cycl seem optim restrict cultur condit mimick natur environ zloti stok gold arsenic mine | D016679 | T028 |
34,681,724 | alter ace ace activ cardiomyocyt signal underli improv myocardi function rat model repeat remot ischem condit post ischem left ventricular lv remodel hypothet prevent repeat remot ischem condit rric male spragu dawley rat studi myocardi infarct mi evok perman ligat left anterior descend coronari arteri lad myocardi characterist test infarct anterior non infarct inferior lv region four andor six week later rric induc three cycl five minut long unilater hind limb ischemia five minut reperfus daili basi period two week start four week lad occlus sham oper anim serv control echocardiograph examin invas hemodynam measur reveal distinct chang lv systol function four six week mi induct absenc rric ie lv eject fraction lvef decreas mean sem p presenc rric ie lvef increas p angiotensin convert enzym ace activ five time higher anterior lv wall six week sham anim angiotensin convert enzym ace activ rough doubl post ischem lvs increas ace ace activ effect mitig rric ca sensit forc product pca lv permeabil cardiomyocyt increas six week mi induct togeth hypophosphoryl cardiac troponin ctni lv region cardiac myosin bind protein c cmybp c anterior wall rric normal pca ctni cmybp c phosphoryl taken togeth post ischem lv remodel involv region specif alter ace ace activ togeth chang cardiomyocyt myofila protein phosphoryl function rric potenti prevent alter improv lv perform follow mi | D057775 | T061 |
34,681,719 | abscop effect review pre clinic clinic advanc radiotherapi use hundr year cure local control tumor regress tumor outsid irradi field occasion observ known abscop effect howev occurr system anti tumor effect deem rare unpredict therapeut goal recent studi suggest immunotherapi radiat combin may enhanc abscop respons increas number case report sinc routin implement immun checkpoint inhibitor show combin radiotherapi immunotherapi synergist effect local distant ie unirradi tumor review summar pre clinic clinic report specif focus mechan behind immunostimulatori effect radiat enhanc immunotherapi | D007167 | T061 |
34,681,711 | sh bind glutam acid rich defici augment apoptosi neonat rat cardiomyocyt congenit heart diseas chd one common birth defect human present around newborn syndrom ds sh domain bind glutam acid rich shbgr gene map ds region belong gene famili encod cluster small thioredoxin like protein share sh domain although express confin cardiac skelet muscl physiolog role shbgr heart poor understood interest observ signific upregul shbgr fail heart mice human patient hypertroph cardiomyopathi along line overexpress shbgr exhibit signific increas express hypertroph marker nppa nppb increas cell surfac area neonat rat ventricular cardiomyocyt nrvcms wherea knockdown attenu cellular hypertrophi mechanist use serum respons factor srf respons element driven luciferas assay presenc absenc rhoa inhibitor found pro hypertroph effect shbgr mediat via rhoa srf axi furthermor shbgr knockdown result induct apoptosi reduc cell viabil nrvcms via apoptot hippo yap signal take result togeth show shbgr vital maintain cytoskelet integr cellular viabil nrvcms modul srfyap signal pathway | D017209 | T043;T116;T123 |
34,681,708 | cyclophilin regul nuclear transloc aif cardiac endotheli cell necroptosi murin cardiac transplant injuri ischemia reperfus injuri iri inevit consequ organ transplant procedur associ acut chronic organ reject transplant iri lead various form program cell death worsen tissu damag acceler transplant reject recent demonstr necroptosi particip murin cardiac microvascular endotheli cell mvec death murin cardiac transplant reject howev mvec death complex iri model studi studi found simul iri condit vitro hypoxia reoxygen treatment inflammatori cytokin induc necroptosi mvec interest apoptosi induc factor aif transloc nucleus mvec necroptosi regul mitochondri permeabl molecul cyclophilin cypd furthermor cypd defici donor cardiac graft inhibit aif transloc mitig graft iri reject n p studi indic cypd aif play signific role mvec necroptosi cardiac transplant reject follow iri target cypd downstream aif may plausibl approach inhibit iri caus cardiac damag improv transplant surviv | D000079302 | T043 |
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