PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,681,706 | structur dynam behaviour colloid compet interact confin slit pore system short rang attract long rang repuls interact form period modul phase low temperatur cluster crystal hexagon lamellar bicontinu gyroid phase period microphas stabl regardless physic origin interact howev yet experiment observ colloid system principl interact tune modifi colloid solut goal investig whether format period microphas promot confin narrow slit pore perform simul simpl model compet interact find cluster crystal lamellar phase stabl higher temperatur bulk system wherea hexagon phase destabilis temperatur somewhat lower bulk besid observ intern order lamellar phase modifi chang pore width interest suffici wide pore host three lamella rang temperatur two lamella close wall intern order wherea one centr pore remain intern disord also find particl diffus confin exhibit complex depend pore width densiti obtain larger smaller valu diffus coeffici correspond bulk system | D056004 | T044;T066 |
34,681,705 | sigma receptor critic mitochondri activ unfold protein respons larval zebrafish sigma receptor sr high conserv transmembran protein high enrich mitochondria associ endoplasm reticulum er membran interact sever partner involv er mitochondria ca transfer activ er stress pathway mitochondria function character new sr defici zebrafish line analyz impact sr defici visual auditori locomotor function sr mutant line show impair visual locomotor function compar srwt locomot sr larva day post fertil increas light dark phase visual motor respons deficit observ acoust startl respons critic role sr shown er stress pathway mitochondri activ use qpcr analyz unfold protein respons gene observ loss sr led decreas level ire perk relat effector increas express effector tunicamycin challeng final sr defici led alter mitochondria bioenerget decreas basal atp link non mitochondri respir follow tunicamycin challeng conclus new zebrafish model confirm import sr activ er mitochondria communic use tool analyz physiopatholog role sr | D056811 | T043 |
34,681,704 | telomer like repeat flank sequenc retrotranscrib telomeras rna insert dna doubl strand break site vertebr genom evolut interstiti telomer sequenc itss stretch telomer like repeat locat intern chromosom site previous demonstr itss insert repair dna doubl strand break cours evolut rodent itss call terc itss flank fragment retrotranscrib telomeras rna compon terc work carri extens search terc itss vertebr genom identifi loci speci includ human primat fragment retrotranscrib terc rna vari differ lineag sequenc seem relat organ terc compar analysi terc itss ortholog empti loci demonstr locus terc like sequenc insert one step cours evolut find suggest telomeras particip peculiar pathway dna doubl strand break repair involv retrotranscript rna compon mechan may activ vertebr speci result add new evid hypothesi rna templat dna repair mechan activ vertebr cell | D019143 | T038 |
34,681,703 | role mitochondria radiat respons epigenet metabol signal impact recent radiat effect consid main due nuclear dna damag manag repair mechan howev molecular biolog studi reveal outcom exposur ioniz radiat ir high depend activ regul molecular compon organell determin cell surviv prolifer capac typic epigenet regul organell central power station cell mitochondria play import pivot role respons direct cellular metabol energi suppli homeostasi well radiat induc signal cell death immunolog respons review focus energi dose qualiti ir affect mitochondria depend epigenet function control cellular tissu level low dose radiat effect mitochondria appear associ epigenet non target effect involv genom instabl adapt respons wherea high dose radiat effect gy concern therapeut effect radiat long term outcom involv mitochondria mediat innat adapt immun respons effect depend radiat qualiti exampl increas efficaci high linear energi transfer particl radiotherapi eg c ion radiotherapi reli reduct anastasi enhanc mitochondria mediat apoptosi immunogen antitumor respons | D011839 | T070 |
34,681,702 | mine fiskebi iii mandarin ottawa express profil understand iron stress toler respons soybean soybean glycin max nbsp l merr genotyp fiskebi iii high resist multitud abiot stress includ iron defici incur mild yield loss stress condit convers mandarin ottawa high suscept diseas suffer sever phenotyp damag yield loss expos abiot stress iron defici major challeng soybean product northern midwestern unit state use rna seq character transcript respons iron defici fiskebi iii mandarin ottawa better understand abiot stress toler previous work group identifi quantit trait locus qtl chromosom associ fiskebi iii iron effici indic fiskebi iii util iron defici stress mechan previous character soybean target potenti candid gene william genom sequenc associ qtl use virus induc gene silenc coupl virus induc gene silenc rna seq identifi singl high prioriti candid gene signific impact iron defici respons pathway character fiskebi iii respons iron stress gene under chromosom qtl provid novel target improv abiot stress toler soybean | D040641;D013312 | T121;T039;T046;T032;T028;T040 |
34,681,700 | water activ predict sugar polyol system use theoret molecular descriptor water activ key factor develop pharmaceut cosmet food product aqueous solut nonelectrolyt norrish model provid simpl effect way evalu quantiti howev contain paramet known norrish constant must estim experiment data studi new strategi propos predict water activ absenc experiment inform base use theoret molecular descriptor character effect solut approach appli evalu water activ presenc sugar glucos fructos xylos sucros polyol sorbitol xylitol glycerol erythritol use two descriptor relat constitut connect properti solut first investig subsequ new theoret descriptor name global inform index g develop use index water activ curv binari system reconstruct posit result obtain support propos strategi well possibl includ singl inform index main molecular featur solut determin effect water activ | D008962 | T062;T170 |
34,681,697 | synthesi investig build block dibenzo b f oxepin use photopharmacolog synthesi photoswitch azo dibenzo b f oxepin deriv microtubul inhibitor describ subsequ examin reaction methoxi deriv nitrodibenzo b f oxepin differ aldehyd presenc bf oet catalyst studi provid concis method construct azo dibenzo b f oxepin skeleton analysi product run use experiment theoret method next evalu e z isomer azo dibenzo b f oxepin deriv could photochem control use visibl wavelength light | D008027;D015394;D010777 | T070;T085;T090 |
34,681,691 | proteom nucleotid profil tool biomark drug target discoveri proteom gone tremend develop recent decad | D055808;D040901 | T091;T062 |
34,681,690 | direct base excis repair mediat regul gc rich cis element respons formylcytosin carboxycytosin stepwis oxid epigenet mark methylcytosin base excis repair ber result formylcytosin fc carboxycytosin cac may provid mechan reactiv epigenet silenc gene howev function fc cac defin gene element scarc explor analyz express report construct contain either deoxi fc cac ber resist fluorin analog asymmetr incorpor cg dinucleotid gc box cis element tgggcggagc upstream rna polymeras ii core promot absenc ber cac caus strong inhibit promot activ wherea fc almost effect similar methylcytosin hydroxymethylcytosin ber cac caus transient signific promot reactiv succeed silenc follow hour respons strict requir thymin dna glycosylas tdg howev silenc phase addit demand endonucleas like ape activ also induc fc apurinicapyrimidin site propos cac may act repressori mark prevent prematur activ promot undergo final stage dna demethyl symmetr cpg methyl alreadi lost remark downstream promot activ repress respons regul two separ ber step tdg ape act potenti switch | D018899;D004249;D004260;D011401 | T049;T114;T045;T123 |
34,681,688 | beginn introduct skin stem cell wound heal primari function skin physic barrier environ divers pathogen therefor integr essenti surviv skin regener depend multipl stem cell compart within epidermi despit differ transcript prolif capac well differ anatom locat fall general term skin stem cell sscs skin wound normal heal without problem howev diseas extens damag may delay prevent heal non heal wound repres serious life threaten scenario may requir advanc therapeut strategi regard increas focus direct sscs role wound heal although emerg therapeut approach consid use stem cell instead mesenchym stem cell mscs given extens broad natur review suppli newcom introduct sscs wound heal therapeut strategi skin regener thus familiar reader subject prepar futur depth read | D012038;D014945 | T040;T042 |
34,681,687 | effect photobiomodul bone defect repair diabet rat model purpos studi examin prospect therapeut effect photobiomodul heal bone defect diabet mellitus dm use rat model provid basic knowledg photobiomodul therapi pbmt bone defect repair vitro studi alizzarin red stain assay use evalu effect pbmt osteogen differenti vivo studi micro comput tomographi microct scan h e ihc stain analysi use investig effect pbmt heal experiment calvari defect mm diamet diabet rat model vitro studi high glucos group show lower osteogen differenti irradi non irradi pbmt compar control group pbmt group control osmot control high glucos show higher osteogen differenti compar non irradi group vivo studi hyperglycem group show signific lower bone regener compar control group pbmt volum bone regener increas back similar level control group treatment pbmt nm could improv bone defect heal diabet rat calvari defect model | D001861;D028022;D010012 | T042;T061 |
34,681,686 | clomiphen citrat show effect sustain antimicrobi activ mycobacterium abscessus mycobacterium abscessus abscessus caus chronic pulmonari infect difficult non tubercul mycobacteria ntm treat due resist current antimicrobi drug treatment success rate thus novel treatment drug need identifi drug clomiphen citrat cc known treat infertil women exhibit inhibitori activ abscessus assess potenti cc treatment abscessus pulmonari diseas measur efficaci vitro establish intracellular activ cc abscessus human macrophag cc signific inhibit growth wild type abscessus strain also clinic isol strain clarithromycin clr resist strain abscessus cc drug efficaci cytotox infect macrophag furthermor cc work anaerob non replic condit well presenc biofilm result vitro studi abscessus activ suggest possibl use cc develop new drug hypothes treatment abscessus infect | D008264 | T025 |
34,681,685 | il ecosystem head neck cancer possibl therapeut perspect interleukin il high potent cytokin involv multipl biolog process previous report play distinct role inflamm autoimmun psychiatr disord age various type cancer furthermor understood il signal pathway substanti player orchestr cancer microenviron thus appear potenti target anti tumor therapi aim articl elucid role il tumor ecosystem review possibl therapeut approach head neck cancer | D059016 | T070 |
34,681,684 | presurg studi curcumin combin anthocyanin supplement patient colorect adenomat polyp adenomat polyp precancer lesion associ higher risk colorect cancer crc curcumin anthocyanin shown promis crc prevent activ preclin epidemiolog studi object window opportun proof principl trial evalu effect curcumin combin anthocyanin supplement tissu biomark colorect adenomat polyp elig patient receiv either anthocyanin curcumin supplement relat match placebo week polyp remov adenomat polyp adjac tissu biopsi collect baselin supplement immunohistochem assess catenin nf kappa b nf b ki p dysplasia differ observ baselin biomark express normal dysplast tissu combin anthocyanin curcumin result signific borderlin reduct nf b immunohistochemistri ihc express adenoma tissu geometr mean ratio gmr confid interv ci p valu trend reduct ki gmr ci p valu signific modul biomark normal adjac mucosa observ conclud combin supplement anthocyanin curcumin seem lead potenti favor modul tissu biomark inflamm prolifer colon adenoma | D019587 | T168;T061 |
34,681,683 | resvega nutraceut omega resveratrol supplement reduc angiogenesi preclin mous model choroid neovascular age relat macular degener amd eye diseas character damag central part retina macula affect million peopl worldwid advanc stage blind spot grow center vision sever handicap patient degen condit despit therapeut advanc thank use anti vegf mani resist mechan found accentu visual deficit present studi explor whether supplement resvega nutraceut formul compos omega fatti acid resveratrol well known polyphenol grape abl counteract laser induc choroid neovascular cnv mice highlight resvega signific reduc cnv mice compar supplement contain omega resveratrol alon moreov proteom approach confirm resvega could counteract progress amd pleiotrop effect target key regul neoangiogenesi retina cell vivo event associ accumul resveratrol metabolit within retina therefor supplement omega resveratrol could improv manag slow progress amd patient condit | D019587 | T168;T061 |
34,681,680 | supplement serum deriv extracellular vesicl reinforc antitumor immun induc cryo thermal therapi effect cancer therapi reshap immunosuppress trigger antitumor immun previous develop novel cryo thermal therapi appli local rapid cool follow rapid heat tumor tissu could ablat local tumor also subsequ induc system long term antitumor immun hyperthermia induc releas extracellular vesicl ev stimul antitumor immun examin whether ev releas cryo thermal therapi whether could improv efficaci cryo thermal therapi model studi serum extracellular vesicl sev isol character h cryo thermal therapi subcutan tumor sev phagocytosi observ vitro vivo use laser confoc microscopi flow cytometri cryo thermal therapi sev administ mice via tail vein chang immun cell investig use flow cytometri cryo thermal therapi larg number sev releas peripheri carri danger signal tumor antigen sev could phagocytos peripher blood monocyt differenti macrophag cryo thermal therapi supplement sev releas treatment promot differenti myeloid deriv suppressor cell mdscs monocyt macrophag cd cell th subtyp well prolong long term surviv subcutan tumor bear mice sev releas cryo thermal tumor treatment could clinic serv adjuv subsequ cryo thermal therapi improv therapeut effect malign tumor | D017679;D000067128 | T026;T061 |
34,681,678 | anxa contain ev regul macrophag polar tumor microenviron promot pancreat cancer progress metastasi tumor microenviron tme dynam system nontumor cancer cell intercommun solubl factor extracellular vesicl ev tme pancreat cancer pc critic aggress annexin anxa identifi one oncogen element previous demonstr autocrineparacrin activ extracellular anxa depend presenc ev show complex anxaev modul macrophag polar contribut cancer progress ev isol wild type wt anxa knock mia paca cell administr thp macrophag find anxa crucial acquisit protumor phenotyp macrophag activ endotheli cell fibroblast induc angiogenesi matrix degrad respect also found signific increas presenc macrophag mice tumor liver metastasi section previous obtain orthotop xenograft wt cell taken togeth data interest suggest relev anxa potenti diagnosticprognost andor therapeut pc marker | D009389;D059016 | T070;T046 |
34,681,677 | select valid refer gene rt qpcr analysi aegilop tauschii coss differ abiot stress aegilop tauschii coss aggress serious annual grass weed china dd genom rich sourc genet materi perform better differ abiot stress condit salin drought temperatur etc revers transcrib quantit polymeras chain reaction rt qpcr reliabl techniqu refer gene select valid work aim evalu stabil refer gene express ae tauschii differ abiot stress salin drought hot cold development stage seedl develop result show ubiquitin conjug enzym e like ubc protein microrchidia like hsp stabl gene control salin condit respect drought stress condit ubc stabl compar other glyceraldehyd phosphat dehydrogenas gadph stabl refer gene heat stress condit thioredoxin like protein yls cold stress condit phosphatea serinethreonin protein phosphatas ppa eukaryot translat initi factor etif stabl gene seedl development stage intracellular transport protein cac recommend stabl gene differ abiot stress development stage furthermor relat express level nhx dreb differ level salin drought stress condit vari hsp ubc least yls act stabl gene studi provid reliabl refer gene understand toler mechan ae tauschii differ abiot stress condit | D018506;D017343;D013312 | T121;T045;T039;T046;T032;T028;T040 |
34,681,675 | structur format mechan antimicrobi peptid temporin b l induc tubular membran protrus temporin famili antimicrobi peptid amp isol frog skin short weak charg high hydrophob execut bactericid activ differ way mani amp work investig morpholog chang planar bilay membran compos mix zwitterion anion phospholipid induc temporin b l tb tl use atom coars grain molecular dynam simul found tb tl fold helic membran surfac penetr shallowli bilay short amp low propens induc membran pore format possess high abil extract lipid relat high peptid concentr strong hydrophob tb tl promot aggreg cluster membran surfac aggreg attract larg amount lipid membran releas compress induc dispers peptid bind membran extrud lipid mix even peptid cluster form tubul like protrus certain water molecul follow movement lipid fill caviti protrus also assist maintain tubular structur contrast peptid free leaflet remain intact present result unravel distinct antimicrobi mechan temporin disturb membran | D056004;D010743 | T044;T066;T109;T123 |
34,681,674 | femal mice selenocystein trna delet agrp neuron maintain leptin sensit resist weight gain high fat diet role essenti trace element selenium hypothalam physiolog begun come light recent year selenium use synthes famili protein particip redox reaction call selenoprotein contain selenocystein residu place cystein past studi shown disrupt selenoprotein express hypothalamus advers impact energi homeostasi also evid selenium support leptin signal hypothalamus maintain proper redox balanc studi generat mice condit knockout selenocystein trna ser sec gene trsp orexigen cell popul call agouti relat peptid agrp posit neuron found femal trspagrpko mice gain less weight high fat diet occur due chang adipos tissu activ femal trspagrpko mice also retain hypothalam sensit leptin administr male mice unaffect howev highlight sexual dimorph influenc selenium neurobiolog energi homeostasi find provid novel insight role selenoprotein within small yet heavili influenti popul hypothalam neuron | D059305 | T061 |
34,681,672 | minispheroid tool ligament tissu engin self assembl techniqu spheroid dimens influenc cruciat ligamentocyt phenotyp spheroid cultur might stabil ligamentocyt phenotyp therefor phenotyp lapin cruciat ligamentocyt l cls minispheroid prepar either hang drop hd method use novel spheroid plate sp option methyl cellulos mc tune spheroid format test total l cls per spheroid seed hds sp perform cell viabil assay morphometri gene express qrt pcr protein immunoloc hdsp sp day stabl viabl spheroid size could produc method rapid sp mc acceler format round spheroid hd circular area decreas signific cultur day diamet hd deriv spheroid signific larger compar harvest sp tendenc lower circular suggest ellipsoid shape gene express decorin increas signific day hd similar trend sp tenascin c tend increas hdsp day sp wherea collagen type decreas hdsp compar monolay control cruciat ligament extracellular matrix compon could local mini spheroid confirm conserv express profil suitabl ligament tissu engin | D023822 | T061 |
34,681,669 | impact matur myocardi respons ischemia effect remot precondit male rat age attenu cardiac toler ischemiareperfus ir associ defect protect cell signal howev onset phenotyp complet investig studi aim compar chang respons ir effect remot ischem precondit ripc heart younger adult month matur adult month male wistar rat chang select protein protect signal langendorff perfus heart expos min min r without prior three cycl ripc pressur cuff inflationdefl hind limb infarct size incid ventricular arrhythmia recoveri contractil function lvdp serv end point age group left ventricular tissu sampl collect prior ischemia baselin ir non ripc control ripc group detect select pro surviv protein western blot matur affect post ischem recoveri heart function left ventricular develop pressur lvdp howev increas arrhythmogenesi accompani decreas level activ sever pro surviv protein higher level pro apoptot protein heart elder anim ripc reduc occurr reperfus induc ventricular arrhythmia contractil dysfunct younger anim preserv matur adult ripc increas phosphoryl protein kinas b p akt total akt ratio endotheli nitric oxid synthas eno protein kinas c pkc prior ischemia ir phosphoryl glycogen synthas kinas gsk increas inactiv ischemia age group coupl decreas level pro apoptot marker assum resist rat heart ir injuri start alreadi declin matur ripc may repres clinic relev cardioprotect intervent elder popul | D019157 | T061 |
34,681,661 | comparison distinct host specif respons three solanacea host induc phytophthora infestan three solanacea host tshs tuberosum n benthamiana lycopersicum repres three major phylogenet clade solanacea plant infect phytophthora infestan caus late blight one devast diseas serious affect crop product howev detail regard differ solanacea host respond p infestan lack conduct rna seq analyz transcriptom data tshs h post p infestan inocul captur earli express effect macroscop microscop observ show faster infect process tuberosum n benthamiana lycopersicum condit analysi number gene level express indic distinct respons model adopt tshs respons p infestan host specif infect process led overlap distinct go term kegg pathway enrich differenti express gene mani tight link immun respons tshs tuberosum show fastest respons strongest accumul reactiv oxygen speci compar n benthamiana lycopersicum also similar differ hormon regul collect studi provid import refer better understand late blight respons mechan differ solanacea host interact | D059467 | T086;T081 |
34,681,660 | blood base immun profil combin machin learn discrimin psoriat arthriti psoriasi patient psoriasi pso chronic inflammatori skin diseas pso patient develop psoriat arthriti psa lead irrevers joint damag earli detect psa pso patient crucial time treatment difficult dermatologist implement therefor aim find diseas specif immun profil discrimin pso psa patient possibl facilit correct identif pso patient need referr rheumatolog clinic phenotyp peripher blood immun cell consecut pso psa patient analyz diseas specif immun profil identifi via machin learn approach approach result random forest classif model capabl distinguish psa pso mean auc key psa classifi cell subset select includ increas proport differenti cdcdcd cd cdcd cd cd cell reduc proport cd cd monocyt memori cd cd cell subset cd regulatori cell within psa joint score show associ memori cdcdra cd effector cell cd monocyt conclud integr depth flow cytometri machin learn identifi immun cell profil discrimin psa pso immun profil may aid time diagnos psa pso | D000069550 | T066 |
34,681,653 | quantum artifici neural network approach deriv high predict qsar model blood brain barrier passag success passag blood brain barrier bbb essenti prerequisit drug molecul design act central nervous system logarithm blood brain partit logbb serv effect index molecular bbb permeabl use three dimension distribut molecular electrostat potenti esp numer descriptor quantit structur activ relationship qsar model term alphaq deriv predict molecular logbb valu obtain optim atom coordin molecul investig pairwis structur align conduct way maxim quantum mechan cross correl templat target molecul align method advantag convent atom atom match protocol structur divers molecul analyz rigor chemic deriv scaffold inaccuraci problem structur align allevi larg part categor molecul eight subset accord molecular weight appli artifici neural network algorithm associ fulli quantum mechan esp descriptor extens experiment logbb data high predict qsar model deriv molecular subset squar correl coeffici larger due simplic model build high predict alphaq anticip serv effect comput screen tool molecular bbb permeabl | D016571;D021281 | T170;T081 |
34,681,650 | discoveri lactoferrin stimul hadsc deriv ev secret proof enhanc result ev skin model extracellular vesicl ev secret hadsc low concentr make difficult util develop therapeut product overcom problem associ low concentr propos human lactoferrin hlf stimul secret hadsc deriv ev hlf report upregul intracellular ca known capabl increas ev secret cultur hadsc hlf supplement media analyz chang intracellular ca concentr characterist hadsc deriv ev secret hlf stimul analyz number membran protein marker presenc hlfs ev function hadsc deriv ev investig effect dermal fibroblast found hlf help hadsc effect uptak ca result increas ev secret factor result ev enhanc prolifer collagen synthesi effect dermal fibroblast compar number hadsc deriv ev secret without hlf stimul enhanc secret hadsc deriv ev increas collagen synthesi enhanc epiderm penetr result increas ev number summari propos hlf use stimul increas secret rate hadsc deriv ev | D008954 | T075 |
34,681,649 | mpapathwaytool user friend automat assign microbi communiti data metabol pathway taxonom function character microbi communiti divers environ human gut bioga plant multi omic method play ever import role research assign identifi gene transcript protein biolog pathway better understand function singl speci microbi communiti howev due versal microbi metabol still increas number newli biolog pathway linkag standard pathway map kegg central carbon metabol often problemat success implement valid new user friend stand alon web applic mpapathwaytool consist two part call pathway creator pathway calcul pathway creator enabl easi set user defin pathway specif taxonom constraint pathway calcul automat map microbi communiti data multipl measur select pathway visual result mpapathwaytool implement java reactj | D014584 | T170 |
34,681,641 | g quadruplex target fight virus updat g quadruplex gs noncanon nucleic acid structur involv regul key cellular process transcript replic sinc discoveri gs main investig role cancer target anticanc therapi recent explor presenc role gs viral genom led discoveri g regul key viral pathway context employ select g ligand help understand complex g mediat mechan viral life cycl highlight possibl target viral gs emerg antivir approach research field grow fast pace provid increas evid antivir activ old new g ligand review aim provid punctual updat literatur g ligand exploit virolog differ class g binder describ emphasi possibl antivir applic emerg diseas current covid pandem strength weak g target virus discuss | D054856 | T086 |
34,681,640 | atpa mutant aldosteron produc adenoma lead cell prolifer molecular mechan atpa mutat mediat cell prolifer tumorigenesi aldosteron produc adenoma apa elucid first investig whether apa associ atpa lr mutat stimul cell prolifer second aim clarifi molecular mechan atpa mutat mediat cell prolifer perform transcriptom analysi apa atpa mutat atpa lr mutat modul human adrenocort carcinoma hac cell atpa mutant cell evalu cell prolifer molecular signal event transcriptom immunohistochem analysi show nak atpas nka express atpa mutat apa abund non function adrenocort adenoma kcnj mutat apa signific increas number cell amount dna phase popul shown atpa mutant cell fluo atpa mutant cell signific increas low concentr ouabain stimul cell prolifer atpa mutant cell atpa mutant cell induc src phosphoryl low concentr ouabain supplement show src phosphoryl demonstr nkas high express atpa mutant apa mutant stimul cell prolifer src phosphoryl atpa mutant cell nka stimul would risk factor progress develop atpa mutant apa | D049109 | T043 |
34,681,639 | role mscs cell fusion tissu regener regen medicin concern investig therapeut agent use promot process regener injuri differ diseas mesenchym stemstrom cell mscs secretom includ extracellular vesicl ev great interest due role tissu regener immunomodulatori capac low immunogen far clinic studi conclus show conflict efficaci regard use mscs addit process possibl involv regener might cell fusion process occur physiolog pathophysiolog context affect immun respons due inflamm review role mscs cell fusion tissu regener discuss | D002459;D044968 | T091;T059 |
34,681,635 | evolutionari histori chymas locus locus encod sever major hematopoiet serin proteas sever hematopoiet cell immun system store larg amount proteas cytoplasm granul absolut major proteas belong larg famili chymotrypsin relat serin proteas chymas locus one four loci encod granul associ serin proteas mammal chymas locus encod four gene primat gene mast cell specif chymotrypt enzym chymas cell express asp ase granzym b neutrophil express chymotrypt enzym cathepsin g cell express chymotrypt enzym name granzym h interest locus experienc number quit dramat expans mammalian evolut illustr larg number function proteas gene found chymas locus mice gene rat gene separ expans also occur rumin find new class proteas gene duodenas express intestin region contrast opossum two function gene locus mast cell mc chymas granzym b low number gene may result invers may hinder unequ cross mechan may major factor expans within rodent lineag chymas locus trace back earli tetrapod gene cluster mammalian gene phylogenet tree found frog allig turtl appear lost bird present collect data concern evolut rapid evolv locus chang gene number specif may affect immun function various tetrapod speci | D019143 | T038 |
34,681,626 | integr epigenet mechan non genotox carcinogen hazard assess focus dna methyl histon modif epigenet involv seri mechan entail histon dna coval modif non code rnas collect contribut program cell function differenti epigenet anomali dna mutat co driver cellular dysfunct includ carcinogenesi alter epigenet system occur cancer whether initi carcinogen event genotox gtxc non genotox ngtxc carcinogen ngtxc inher dna reactiv unifi mode action yet regulatori test guidelin address mechan ngtxc fil gap test guidelin programm organis econom cooper develop develop framework integr approach test assess iata ngtxc consid assay address key event cancer hallmark intent better understand applic epigenet assay chemic carcinogen assess focus dna methyl histon modif review epigenet mechan contribut carcinogenesi epigenet mechan alter follow exposur arsenic nickel phenobarbit order identifi common carcinogen specif mechan characterist seri epigenet assay type epigenet assay valid need context chemic hazard assess key compon numer ngtxc mechan action epigenet assay includ iata assay combin contribut improv chemic carcinogen identif better protect public health | D019175;D057890 | T091;T044 |
34,681,618 | androgen receptor activ glioblastoma achiev ligand independ signal egfr potenti therapeut target androgen receptor ar ligand mediat transcript factor belong superfamili steroid receptor ar overexpress glioblastoma potenti therapeut target prostat breast cancer ar activ achiev also ligand independ signal receptor tyrosin kinas epiderm growth factor receptor egfr consid major role glioblastoma explor whether egfr involv ar signal tumor analysi mrna express glioblastoma sampl quantit real time revers transcript polymeras chain reaction reveal posit signific correl ar egfr mrna express level r p valid cancer genom atlas dataset n analysi r p use western blot immunofluoresc stain show transduc overexpress egfr variant egfrviii umg cell induc ar protein overexpress nuclear transloc protein kinas b akt ar phosphoryl egfr kinas inhibitor afatinib akt inhibitor mk reduc ar nuclear transloc afatinib diminish akt phosphoryl min h egfr egfrviii overexpress cell respect decreas ar phosphoryl egfr overexpress cell h afatinib mk combin therapi ar antagonist enzalutamid egfr egfrviii overexpress cell synergist efficaci find suggest egfr signal involv ar activ glioblastoma buttress concept combin egfr signal inhibitor ar antagonist potenti glioblastoma treatment | D008024;D015398 | T043;T044;T103 |
34,681,617 | polycycl aromat hydrocarbon detect process meat caus genet chang colorect cancer polycycl aromat hydrocarbon pah common ingest via meat produc high temperatur cook meat pah potenti role carcinogenesi colorect cancer crc aim investig pah concentr eight type common consum readi eat meat sampl potenti effect gene express relat crc extract clean meat sampl perform use quecher method pah detect use gc ms nine differ pah found meat sampl interest roast turkey contain highest total pah content follow salami meat ham vari level smoked show proport increas phenanthren phen anthracen anth fluoren flu tripl smoke ham sampl show signific higher level pah compar singl smoke ham three pah plus benzo pyren b p detect three meat sampl chosen treatment investig vitro gene express chang human colon cell pah treatment total rna extract rtpcr perform investig gene express relat crc b p decreas mrna express tp addit high concentr b p signific increas kras express treatment phen flu signific increas kras mrna express vitro impli potenti basi pah induc colorect carcinogenesi oppos anth treatment led increas tp apc express decreas kras express suggest anti carcinogen effect conclud pah common readi eat meat sampl capabl signific modifi express key gene relat crc | D005786 | T045 |
34,681,615 | elucid carfilzomib induc cardiotox vivo model age prophylact potenti metformin carfilzomib first line proteasom inhibitor indic relapsedrefractori multipl myeloma mm clinic use hamper cardiotox phenomena previous establish translat model carfilzomib cardiotox young adult mice metformin emerg prophylact therapi consid mm elder diseas age independ risk factor cardiotox herein sought valid carfilzomib cardiotox vivo model age | D000375 | T040;T033 |
34,681,604 | ampelopsin confer endur rehabilit mechan glycin max cv sowonkong multipl abiot stress present investig aim perceiv effect exogen ampelopsin treatment salin heavi metal damag soybean seedl glycin max l term physiochem molecular respons screen numer ampelopsin concentr soybean seedl growth indic concentr display increas agronom trait studi also determin ampelopsin applic could recov salin heavi metal damag plant soybean seedl irrig water nacl mm chosen heavi metal day result show applic ampelopsin rais surviv day old salin heavi metal stress soybean plant ampelopsin treat plant sustain high chlorophyl protein amino acid fatti acid salicyl acid sugar antioxid activ prolin content display low hydrogen peroxid lipid metabol abscis acid content unfavor status gene express survey reveal ampelopsin applic led improv express gmnac gmfdl gmfad gmapx gmwrki gmwrki gmsap gene reduc express gmerf gene studi suggest irrig ampelopsin allevi plant damag improv plant yield stress condit especi includ salin heavi metal | D013312 | T121;T039;T046;T032;T040 |
34,681,603 | ferroptosi crossroad gemcitabin resist tumorigenesi pancreat cancer overal five year surviv rate pancreat cancer hard chang past decad less resist known therapi includ chemotherapeut drug past decad gemcitabin forefront treatment pancreat ductal adenocarcinoma strategi combat drug resist need explor one promis possibl ferroptosi form nonapoptot cell death depend intracellular iron occur accumul lipid reactiv oxygen speci signific drug resist articl review gemcitabin resist mechan assess relationship among ferroptosi tumorigenesi gemcitabin resist explor new treatment method pancreat cancer | D000079403 | T043 |
34,681,601 | cardiac telocyt year learn far close routin applic knowledg cardiovascular regen medicin regener diseas heart one princip challeng modern cardiovascular medicin ongo research stem cell base therapeut approach cell popul call telocyt tcs describ year ago larg contribut research area cardiovascular regener tcs cell small bodi extrem long cytoplasm project call telopod describ layer heart wall function includ cell cell signal stem cell nurs mechan support immunoregul name function derang quantit loss tcs implic pathogenesi myocardi infarct heart failur arrhythmia mani condit exact pathomechan still unknown loss regul integr nurs function tcs may provid import clue therefor viabl avenu futur modern manag condit tc base cell therapi tcs previous transplant mous model myocardi infarct promis result tandem transplant stem cell may provid addit benefit howev mani underresearch area need address futur research routin applic tc base cell therapi human subject includ standard protocol isol cultiv transplant quantit optim tc transplant cost effect analysi mani other | D044968 | T091 |
34,681,600 | exercis intervent mitig patholog liver chang nafld zebrafish activ sirtampknrf signal non alcohol fatti liver diseas nafld common diseas caus serious liver damag exercis recogn non pharmacolog tool improv patholog nafld howev antioxid effect mechan exercis amelior nafld remain unclear present studi conduct exercis train zebrafish week high fat feed period studi antioxid effect exercis liver found swim exercis decreas lipid accumul improv patholog chang liver high fat diet fed zebrafish moreov swim allevi nox deriv reactiv oxygen speci ros overproduct reduc methanedicarboxyl aldehyd mda level also examin anti apoptot effect swim found increas express antiapoptot factor bcl decreas express gene associ apoptosi caspas bax mechanist swim intervent activ sirtampk signal mediat lipid metabol inflamm well enhanc akt nrf activ upregul downstream antioxid gene summari exercis attenu patholog chang liver induc high fat diet under mechan might relat nrf mediat sirtampk signal | D015398 | T043;T044 |
34,681,599 | systemat approach molecular dynam studi parametris gemini type cation surfact spread antibiot resist bacteria strain one serious problem medicin struggl nowaday trigger develop altern antimicrobi agent recent year one group gemini surfact massiv synthesis various structur configur obtain effect antibacteri properti unfortun comparison antimicrobi effect among differ type gemini agent unfeas sinc various protocol determin minimum inhibitori concentr use work propos altern comput approach comparison design comprehens databas gemini surfact descript structur paramet instanc spacer type length includ databas parametris model molecul obtain forc field entir gemini databas use conduct silico studi use molecular dynam investig incorpor agent model e coli inner membran system evalu effect gemini surfact structur stress mechan paramet membran agent incorpor enabl us select four like membran properti could correspond gemini antimicrobi effect base result select sever type gemini spacer could demonstr particular strong effect bacteri membran | D056004 | T044;T066 |
34,681,597 | enzym replac therapi pabinafusp alfa neuronopath mucopolysaccharidosi ii integr analysi preclin clinic data enzym replac therapi ert improv somat manifest mucopolysaccharidos mps howev intraven administ enzym cross blood brain barrier bbb ert ineffect progress neurodegener result sever central nervous system cns symptom observ patient neuronopath mps attempt surmount problem made intrathec intracerebroventricular ert order achiev cns effect burden patient inim long term administr howev sinc pabinafusp alfa human iduron sulfatas fuse bbb cross anti transferrin receptor antibodi show central peripher efficaci mous model subsequ clinic trial total patient mps ii hunter syndrom japan brazil substanti dual efficaci provid accept safeti profil date pabinafusp alfa approv intraven ert effect somat cns symptom patient mps ii articl summar previous obtain preclin clinic evid relat use drug present latest data discuss preclin translat clinic challeng evalu amelior prevent neurodegener patient mps ii | D056947 | T061 |
34,681,589 | quantit estim index earli stage screen compound target protein protein interact drug like quantif use screen drug candid quantit estim drug like qed common use assess quantit drug efficaci suitabl screen compound target protein protein interact ppis recent gain attent therefor develop quantit estim index compound target ppis qeppi specif earli stage screen ppi target compound qeppi extens qed method ppi target drug model physicochem properti base inform avail drugscompound specif report act ppis fda approv drug compound ippi db compris ppi inhibitor stabil evalu use qeppi result show qeppi suitabl qed earli screen ppi target compound qeppi also consid extend concept rule four ro ppi inhibitor index evalu discriminatori perform qeppi ro dataset ppi target compound fda approv drug use f score indic f score ro qeppi respect qeppi show better perform enabl quantif drug like earli stage ppi drug discoveri henc use initi filter effici screen ppi target compound | D060066 | T169 |
34,681,584 | molecular mechan food deriv polyphenol pd l dimer molecular dynam simul studi cancer immunotherapi emerg approach block interact program cell death pd program cell death ligand pd l use small molecul inhibitor food deriv polyphenol curcumin cc resveratrol rsv epigallocatechin gallat egcg anticanc immunolog function recent propos act via downregul pd l express howev remain unclear whether direct target pd l dimer thus interrupt pd pd l pathway elucid molecular mechan compound pd l dimer molecular dock nanosecond molecular dynam simul perform bind free energi calcul show affin cc rsv egcg pd l dimer follow trend cc rsv egcg henc cc effect inhibitor pd pd l pathway analysi contact number nonbond interact residu energi decomposit indic compound main interact c f g sheet fragment pd l dimer involv interact pd import nonpolar interact compound key residu ile tyr met ala tyr play domin role bind free energi landscap secondari structur analys demonstr compound stabli interact bind domain pd l dimer result provid evid cc rsv egcg inhibit pd pd l interact direct target pd l dimer provid novel approach discov food deriv small molecul inhibitor pd pd l pathway potenti applic cancer immunotherapi | D056004 | T044;T066 |
34,681,583 | k ras act critic regul cd promot invas stem gbm respons ioniz radiat radiat therapi current standard care treatment use wide gbm patient howev radiat therapi still remain signific barrier get success outcom due therapeut resist tumor recurr understand under mechan resist recurr would provid effici approach improv therapi gbm treatment identifi regulatori mechan cd induc infiltr mesenchym shift gbm ioniz radiat ir induc k raserk signal activ elev cd express downregul mir mir express high express cd promot src activ induc cancer stem emt featur gbm cell studi demonstr k raserkcd axi key mechan regul mesenchym shift gbm cell irradi find suggest block k ras activ cd express could provid effici way gbm treatment | D011839 | T070 |
34,681,581 | ampk local key differenti energi regul central node nutrit signal input metabol pathway amp activ protein kinas ampk tight regul maintain energi homeostasi subcellular compartment ampk one critic regul enabl ampk access proper target generat appropri respons specif perturb differ level stress one character local mechan rangtpas driven crm recogn nuclear export sequenc nes subunit transloc ampk cytoplasm nuclear local putat employ rangtpas driven importin might recogn nuclear local signal nls present ampk kinas domain nucleo cytoplasm shuttl ampk influenc multipl factor starvat exercis heat shock oxid cell densiti circadian rhythm tissu specif local distribut ampk trimer differ combin also shown vital maintain tissu specif metabol tissu specif subcellular distribut ampk might attribut differ express subunit stabil protein regul tissu activ local ampk activ consid import ampk local coordin signal metabol research due fulli elucid larg unknown complex mechan under regul | D004734 | T040;T039 |
34,681,578 | photoactivat nanocrisprca system base crrna revers immobil carbon nanoparticl propos new approach engin photoactivat crisprca gene edit system novel nanocrisprca system base use auxiliari photocleav oligodeoxyribonucleotid pc dnas complementari crrna pc dnas contain three uv sensit linker made nitrophenyl ethanediol insid oligonucleotid chain immobil pc dnas surfac carbon nanoparticl termin pyren residu provid suffici block crrna correspond cas activ uv irradi allow crrna releas uv irradi nm restor cas activ optim length block photocleav oligonucleotid number linker time irradi type carbon nanoparticl base result consid nanocrisprca system involv carbon encapsul iron nanoparticl promis provid greatest differ function activ beforeaft irradi use prospect magnet field control deliveri crispr system target cell tissu spatiotempor gene edit induc uv irradi | D064113 | T040 |
34,681,570 | associ ovarian teratoma anti n methyl aspart receptor enceph updat integr review ovarian teratoma far common ovarian germ cell tumor teratoma benign unless somat transform occur design teratoma refer neoplasm differenti toward somat type cell popul recent research show strike associ ovarian teratoma anti n methyl aspart receptor anti nmdar enceph rare understudi paraneoplast neurolog syndrom pns among teratoma matur teratoma thought greater relev neurolog impair pns describ neurolog deficit trigger under remot tumor wherea anti nmdar enceph character complex neuropsychiatr syndrom presenc autoantibodi cerebr spinal fluid glun subunit nmdar review aim summar recent report associ anti nmdar enceph ovarian teratoma particular molecular pathway pathogenesi updat mechan diseas model would discuss hope provid depth review issu therefor better understand epidemiolog diagnost approach treatment strategi | D015398 | T043;T044 |
34,681,569 | amala analysi direct evolut experi via anneal mutat approxim landscap present anneal mutat approxim landscap amala new method infer fit landscap direct evolut experi sequenc data experi typic start singl wild type sequenc undergo darwinian vitro evolut via multipl round mutat select target phenotyp last year direct evolut emerg power instrument probe fit landscap control experiment condit relev test ground develop accur statist model infer algorithm thank high throughput screen sequenc fit landscap model either use enrich variant abund input thus requir observ variant differ round assum last sequenc round sampl equilibrium distribut amala aim effect leverag inform encod whole time evolut assum statist sampl independ sequenc round possibl trajectori sequenc space gaug time depend statist weight consist two contribut energi term account select process ii general juke cantor model pure mutat step simpl scheme enabl accur describ direct evolut dynam infer fit landscap correct reproduc measur phenotyp select eg antibiot drug resist notabl outperform wide use infer strategi addit assess reliabl amala show infer statist model could use predict relev structur properti wild type sequenc | D009154 | T045 |
34,681,565 | effect manganes genom integr multicellular model organ caenorhabd elegan although manganes mn essenti trace element overexposur associ mn induc toxic neurolog dysfunct even though mn induc oxid stress discuss extens neither under mechan potenti consequ mn induc oxid stress dna damag dna repair possibl result toxic character yet studi use model organ caenorhabd elegan investig mode action mn toxic focus genom integr mean dna damag dna damag respons experi conduct analyz mn bioavail lethal induct dna damag differ delet mutant strain use investig role base excis repair ber deparyl dna damag respons protein mn induc toxic result indic dose time depend uptak mn result increas lethal excess exposur mn decreas genom integr activ ber altogeth studi character consequ mn exposur genom integr therefor broaden molecular understand pathway under mn induc toxic addit studi basal poli adp ribosyl paryl worm lack poli adp ribos glycohydrolas parg parg parg two orthologu parg indic parg account glycohydrolas activ worm | D004249 | T049 |
34,681,041 | associ gene gene interact studi late onset alzheim diseas russian popul alzheim diseas ad neurodegen disord repres common caus dementia studi perform sever differ analys detect loci involv develop late onset ad russian popul dna sampl unrel subject genotyp snps use iplex assay real time pcr identifi five genet loci signific associ load risk russian popul tomm rs apo rs rs nectin rs apo result analysi base comparison haplotyp frequenc show two risk haplotyp one protect haplotyp gmdr analysi demonstr three signific model result one factor two factor three factor model protein protein interact network three subnetwork form protein eight protein larg number interact identifi apo sorl apoc cd clu tomm cntnap cacnac present studi confirm import apo tomm locus main risk locus develop progress load russian popul associ analysi bioinformat approach detect interact associ level singl snps level gene protein | D056726;D020022 | T033;T032;T063 |
34,681,040 | fa nf function annot pipelin protein non model organ implement nextflow function annot allow ad biolog relev inform predict featur genom sequenc therefor import procedur de novo genom sequenc project also use proofread improv gene structur annot introduc fa nf pipelin implement nextflow versatil comput workflow manag engin pipelin integr differ annot approach ncbi blast diamond interproscan kegg start protein sequenc fasta file option structur annot file gff format produc sever file go assign output summari abovement program final annot report pipelin broken easili smaller process purpos parallel easili deploy linux comput environ thank softwar container thus help ensur full reproduc | D012984 | T170;T073;T090 |
34,681,038 | genet predict type diabet mellitus liabil glycat hemoglobin cardiovascular diseas wide angl mendelian random studi aim investig causal effect tdm liabil glycat haemoglobin hbac level various cardiovascular diseas outcom general popul non diabet individu specif method select variant genet instrument tdm liabil variant hbac linear mendelian random analys perform estim associ genet predict tdm liabil hbac cardiovascular diseas outcom unrel uk biobank particip european ancestri perform secondari analys particip without diabet hbac diagnos diabet particip without diabet pre diabet hbac diagnos diabet result genet predict tdm liabil posit associ p peripher vascular diseas aortic valv stenosi coronari arteri diseas heart failur ischaem stroke stroke genet predict hbac posit associ coronari arteri diseas stroke mendelian random estim general shift toward null exclud diabet pre diabet particip analys conclus genet evid support causal effect tdm liabil hbac rang cardiovascular diseas suggest improv glycaem control could reduc cardiovascular risk general popul greatest benefit individu diabet | D020022 | T032 |
34,681,037 | mitochondri stroke diagnost challeng chameleon mitochondri stroke like episod sles hallmark mitochondri encephalomyopathi lactic acidosi stroke like episod mela suspect anyon acutesubacut onset focal neurolog symptom age usual driven seizur suggest featur under mitochondri patholog includ evolv mri lesion often origin within posterior brain region presenc multisystem involv includ diabet deaf cardiomyopathi posit famili histori diagnosi mela import implic affect relat given enabl earli initi appropri treatment genet counsel howev diagnosi frequent challeng particular acut phase event describ four case mitochondri stroke highlight consider overlap exist neurolog disord includ viral autoimmun enceph ischem stroke central nervous system cns vascul discuss clinic laboratori imag featur help distinguish mela differenti diagnos | D003937 | T060 |
34,681,036 | associ pipka polymorph alcohol use disord alcohol use disord aud influenc individu famili also last social impact communiti nation level dopaminerg neurotransmiss involv excess alcohol consumpt phosphatidylinositol phosphat kinas type pipka play import role regul ascend dopamin pathway studi determin possibl associ nine polymorph pipka aud russian men | D020022;D055106 | T032;T063 |
34,681,035 | evalu associ comt rs polymorph swimmer competit perform swimmer competit perform result complic interact physiolog biochem physic psycholog factor strong affect water recent great attent paid role genet factor catechol methyltransferas gene comt influenc motiv emot stress toler self control sleep regul pain process percept addict behaviour neurodegener may underli differ achiev remark result sport competit thus studi perform investig associ comt valmet rs polymorph athlet perform caucasian swimmer total swimmer short distanc sds long distanc swimmer lds nation intern competit standard unrel sedentari control genotyp use real time polymeras chain reaction real time pcr found signific differ genotyp allel distribut male femal athlet sds lds athlet sedentari control codomin domin recess overdomin genet model associ found comt rs polymorph elit swim athlet status studi popul howev replic studi need | D056352 | T097;T098 |
34,681,034 | singl cell rna seq reveal gene express pattern vitro matur donkey oocyt donkey import domest anim provid labor meat milk medicin materi human howev donkey popul continu declin even risk extinct applic modern anim product technolog oocyt vitro matur promis method improv donkey popul studi explor gene express pattern donkey germin vesicl gv vitro matur metaphas ii mii oocyt use singl cell rna seq candid gene along regulatori mechan affect donkey oocyt matur identifi total oocyt gene signific differenti express gv mii oocyt gene ontolog go kyoto encyclopedia gene genom kegg analysi indic gene associ meiotic cell cycl mitochondrion activ n glycan biosynthesi might key gene regulatori mechan affect matur donkey oocyt studi provid consider understand regard matur donkey oocyt serv theoret basi improv develop donkey oocyt could ultim benefit expans donkey popul conserv biodivers genet resourc | D059471;D059010 | T059;T061 |
34,681,033 | atyp nf microdelet challeng opportun genotypephenotyp correl patient larg nf delet patient neurofibromatosi type nf type nf delet often exhibit sever clinic manifest patient intragen nf gene mutat includ facial dysmorph featur overgrowth sever global development delay sever autist symptom consider reduc cognit abil detect young age type nf delet encompass mb associ loss protein code gene includ nf suz atyp nf delet encompass protein code gene locat within type nf delet region potenti contribut delin genotypephenotyp relationship patient nf microdelet review atyp nf delet report date well clinic phenotyp observ patient concern compar find newli identifi atyp nf delet kb addit nf gene includ five gene locat centromer nf atyp nf delet patient includ suz gene encompass crlf compar analysi atyp nf delet suggest suz hemizygos like contribut signific reduc cognit abil sever global development delay facial dysmorph observ patient type nf delet | D017353 | T045 |
34,681,031 | generaliz gwa identifi genet risk variant metabol trait popul arabian peninsula arabian peninsula locat nexus africa europ asia implic earli human migrat arab popul character consanguin endogami lead inbreed global genom wide associ gwa studi metabol trait repres arab popul replic gwa identifi associ signal arab popul satisfactorili explor import assess well gwa identifi find general clinic interpret benefit target popul recent studi kuwait perform genom wide imput meta analysi observ gene gwa identifi metabol risk variant replic arab popul recent larg gwa studi qatar found replic gwa identifi lipid risk variant complement studi peninsula increas confid general metabol risk loci arab popul howev studi report low extent transfer review examin observ low transfer context differ environ genet correl allel frequenc linkag disequilibrium effect size herit phenotyp varianc emphas need larg scale gwa studi deepli phenotyp cohort least arab individu review present gwa identifi metabol risk variant generaliz arab popul | D020022;D005828;D055106 | T032;T063;T090 |
34,681,023 | high dimension singl cell transcriptom melanoma cancer immunotherapi recent advanc singl cell transcriptom great improv knowledg complex transcript program rapid expand knowledg cellular phenotyp function within tumour microenviron immun system sever new singl cell technolog develop recent year enabl expand understand mechanist cell biolog pathway target immunotherapi immun checkpoint inhibitor routin use patient manag high risk earli stage advanc melanoma technolog method specif strength weak capabl need consid utilis answer translat research question provid guidanc implement singl cell transcriptom analysi platform review current avail experiment analysi workflow highlight use technolog dissect tumour microenviron context cancer patient treat immunotherapi strateg use singl cell analyt clinic set discuss potenti futur opportun explor focus use rationalis design novel immunotherapeut drug therapi ultim lead improv cancer patient outcom | D007167 | T061 |
34,681,022 | lineag specif gene famili expans dictyostelid genom display express bias evolutionari diversif develop gene duplic generat new gene contribut express chang evolut new function genom often consist gene famili undergo expans occur specif lineag reflect recent adapt diversif studi lineag specif gene gene famili expans studi across five dictyostelid speci determin express multicellular develop lineag specif gene found enrich among gene bias express predomin express one development stage speci development time point suggest independ function innov new gene throughout phylogeni bias duplic gene greater express diverg ortholog paralog consist subfunction neofunction lineag specif expans particular bias gene molecular signal posit select high express suggest adapt genet transcript diversif follow duplic result present insight potenti contribut lineag specif gene famili generat speci specif phenotyp multicellular develop dictyostelid | D019143;D010802 | T062;T038;T078 |
34,681,020 | prenat diagnosi combin matern q interstiti delet patern q microdupl q delet syndrom well known rare genet condit caus partial termin interstiti delet long arm q chromosom phenotyp syndrom show broad spectrum clinic manifest due great variabl size locat delet literatur most termin delet chromosom q relat phenotyp describ interstiti delet long arm chromosom rare cite report femal fetus present abnorm ultrasound evid multipl chromosom aberr compar genom hybrid acgh reveal interstiti mb delet chromosom region q arr hg qq x combin kb microdupl chromosom q arr hg x birth month babi confirm healthi normal identif case allow deeper understand q syndrom provid explan wide geneticphenotyp spectrum patholog report provid refer prenat diagnosi genet counsel patient similar cytogenet abnorm underlin import report unusu variant chromosom diagnost genet purpos | D002869;D002872;D011296 | T049;T060 |
34,681,019 | wdr associ neurodegener case report highlight possibl mechan normal tension glaucoma wdr one number gene implic pathogenesi adult onset primari open angl glaucoma poag describ detail phenotyp patient pathogen variat wdr present protract histori central vision loss exam visual acuiti level tritan color defect show central arcuat visual field defect visual field test enlarg cup disk ratio normal intraocular pressur associ sever thin ganglion cell layer gcl retin nerv fiber layer consist clinic diagnosi normal tension glaucoma full field electroretinogram reveal sever inner retin dysfunct reduc amplitud remark delay time b wave preserv photoreceptor wave function pattern describ herein recapitul find anim model wdr associ poag suggest mechan diseas involv retina wide inner retin dysfunct neurodegener beyond gcl detail structur function character patient pathogen variant wdr gene requir confirm find | D020022 | T032 |
34,681,018 | structur protein analysi driver gene mutat conjunctiv melanoma recent year tremend enthusiasm respect detail genet basi mani neoplasm includ conjunctiv melanoma cm aim analyz five protein associ cm name braf nras c kit nf pten evalu protein intrins disord protein region idpr protein protein interact ppi predictor natur disord protein region pondr search tool retriev interact gene string pondr analysi found high level idpr five protein mutat link cm highest level idpr braf follow pten nf c kit nras string analysi found five protein predict interact expect p valu analysi demonstr mutat link cm like affect idpr possibl alter high complex ppis quantifi idpr braf nras c kit nf pten understand protein region import process idpr possibl drug target novel target therapi treat cm | D011487 | T082 |
34,681,017 | preval clinic characterist hear loss caus myh variant variant myh report caus autosom domin nonsyndrom hereditari hear loss adnshl variant report caus hear loss various ethnic group howev avail inform preval well regard clinic featur remain fragmentari studi genet screen myh variant carri use larg seri japanes hear loss patient reveal detail inform massiv parallel dna sequenc target candid gene appli unrel japanes hear loss patient includ adnshl identifi genom variat respons hear loss identifi famili variant preval found among hear loss patient among adnshl patient nine eleven variant identifi novel patient typic show late onset hear loss aris later year age along progress moder flat type hear loss also confirm progress hear loss serial audiogram clinic inform reveal present studi contribut diagnosi manag myh associ hear loss | D020022 | T032 |
34,681,016 | associ cypc promot hypomethyl small vessel occlus korean subject risk factor stroke fatal diseas includ type two diabet hypertens genet influenc small vessel occlus svo affect epigenet alter associ svo methyl cytochrom p famili subfamili c member cypc identifi studi measur level dna methyl cypc promot untransl region normal subject patient svo korea dna methyl level subject measur bisulfit amplicon sequenc statist analysi perform use general linear model pearson correl averag level dna methyl mark lower patient svo normal subject vs found methyl cypc signific posit correl blood paramet includ white blood cell hematocrit lactat dehydrogenas na subject svo predict bind rxr rar might affect cypc methyl cpg site find suggest cypc methyl promot region may predictor svo | D019175;D011401 | T044;T114;T123 |
34,681,015 | detect spinal muscular atrophi patient use dri saliva spot spinal muscular atrophi sma lower motor neuron diseas consid incur main symptom muscl weak muscular atrophi case sma caus homozyg delet surviv motor neuron smn emerg treatment splice modul smn smn gene replac therapi improv prognos motor function patient howev confirm diagnosi smn test often delay suggest presenc diagnosi delay undiagnos case enabl patient access right treatment screen system sma essenti even current newborn screen system use dri blood spot still invas cumbersom develop complet non invas screen system use dri saliva spot dss altern dna sourc detect smn delet studi dss sma patient control test combin modifi competit oligonucleotid prime polymeras chain reaction melt peak analysi clear distinguish dss sampl without smn conclus result suggest system dss applic sma patient detect real world | D012463 | T031 |
34,681,014 | role glutathion mediat abscis acid signal regul seed dormanc drought toler plant growth develop interact environ regul phytohormon signal molecul evolut plant develop strategi effici signal percept activ signal transduct cascad maintain proper growth develop particular advers environment condit abscis acid aba one phytohormon known regul plant development event toler environment stress role aba mediat accumul level regul biosynthesi catabol signal influenc complex regulatori mechan stress condit plant employ enzymat non enzymat antioxid strategi scaveng excess reactiv oxygen speci ros mitig negat effect oxid stress glutathion gsh one main antioxid molecul play critic role plant surviv stress condit detoxif excess ros maintain cellular redox homeostasi regul protein function gsh recent emerg import signal molecul regul aba signal transduct associ development event respons stressor review highlight current knowledg interplay aba gsh regul seed dormanc germin stomat closur toler drought | D000222;D055864 | T040;T070 |
34,681,013 | moggi popul genet analysi unit kingdom non pedigre cat domest cat one popular pet world estim domest cat uk non pedigre domest shorthair dsh domest longhair dlh domest semi longhair cat dslh despit popular littl known uk non pedigre cat popul structur breed dynam use custom design singl nucleotid variant snv array studi investig popul genet uk cat princip compon analysi pca faststructur analysi verifi uk dsh dlh dslh cat random bred rather admix mix breed crossbr contrast pedigre cat linkag disequilibrium random bred cat least extens decay rapid homozygos descent hbd analysi show major non pedigre cat proport less genom hbd segment compar pedigre cat segment older togeth find suggest dsh dlh dslh cat consid popul random bred cat rather crossbr pedigre admix cat unexpect random bred cat genom display higher proport hbd segment associ recent inbreed event therefor non pedigre cat whole genet divers impervi inbreed health risk | D005828 | T090 |
34,681,012 | two year clinic descript patient rare type low ggt cholestasi caus novel variant usp report novel truncat mutat ubiquitin specif peptidas gene usp caus low gt ggt cholestasi genet test carri includ clinic exom sequenc proband sanger sequenc proband parent proband harbor novel cdel p cystrpfster mutat ubiquitin carboxyl termin hydrolas uch domain usp describ clinic laboratori featur patient rare type low ggt cholestasi caus variant clinic present found similar phenotyp describ previous studi howev unusu presenc liver hemangioma observ patient thus report reinforc link usp mutat cholestasi report confirm usp gene low ggt cholestasi describ liver hemangioma possibl addit symptom phenotyp spectrum inclus usp omim databas liver gene panel increas effect molecular genet studi | D009154 | T045 |
34,681,009 | epigenet regulatori dynam model methamphetamin use disord methamphetamin meth use disord mud serious potenti lethal biopsychosoci diseas exposur meth caus long term chang brain region involv reward process motiv lead vulner individu engag patholog drug seek drug take behavior remain lifelong struggl crucial elucid under mechan exposur meth lead molecular neuroadapt chang transcript translat level chang gene express control post translat modif via chromatin remodel review articl focus brain region specif combinatori distinct epigenet modif lead meth induc chang gene express | D044127 | T045 |
34,681,007 | genet loci under awn morpholog barley barley awn high activ photosynthesi account grain weight barley divers length rang long awnless shape straight hood crook divers import intrigu geneticist sever decad larg collect awn mutant avail dozen map chromosom recent clone differ awn gene interact produc divers awn phenotyp avail sequenc barley genom applic new map gene clone strategi possibl identifi clone awn gene better understand genet basi awn divers great facilit develop new barley cultivar improv yield adapt sustain | D017343 | T028 |
34,681,006 | genet genom reproduct medicin rapid innov meant reproduct medicin today repres clear exampl complex essenti adapt clinic practic laboratori techniqu new knowledg context dynam evolut medicin | D018456 | T091 |
34,681,005 | flt mutat associ segment lymphat dysfunct initi lymphat aplasia patient milroy diseas studi explor mutat fms relat tyrosin kinas vascular endotheli growth factor receptor gene flt lymphat defect patient milroy diseas md twenti nine patient lower limb lymphedema enrol sixteen patient famili histori md patient exhibit sporad md clinic sign flt mutat indocyanin green icg lymphographi find skin tissu immunohistochem stain result evalu twenti eight variant flt identifi twelv previous report novel variant missens mutat remain two compris splice mutat non frame shift mutat twenti five variant locat intracellular protein tyrosin kinas domain three locat extracellular immunoglobulin domain substanti delay contrast enhanc tortuous lymphat vessel visual ankl knee level patient underw icg lymphographi initi lymphat vessel visual skin specimen four patient exhibit lymphat vessel imag analys specif variant identifi relat uniqu clinic phenotyp segment dysfunct lymphat vessel initi lymphat aplasia present md patient flt mutat | D020022 | T032 |
34,681,003 | methanogenesi salt toler gene novel halophil methanosarcinacea metagenom assembl genom former solar saltern anaerob archaeal methanogen key player global carbon cycl due role final stage organ matter decomposit anaerob environ wetland sediment present first draft metagenom assembl genom mag sequenc unclassifi methanosarcinacea methanogen phylogenet place adjac methanolobus methanomethylovoran genera appear distinct genus speci genom deriv sediment hypersalin ppt chlorid unrestor industri saltern observ signific methan sourc sourc sediment salin previous sourc methanolobus methanomethylovoran propos new genus name methanosali hous genom design strain name sbspra mag bin concoct improv via scaffold extens reassembl genom contain pathway methylotroph methanogenesi trimethylamin dimethylamin well gene synthesi transport compat solut gene involv acetoclast hydrogenotroph methanogenesi present pathway appear incomplet genom mag abund two former industri saltern nearbi refer wetland restor wetland much lower salin level well signific lower methan emiss saltern | D017753 | T070;T082 |
34,681,002 | associ genet express gene involv hpa axi suicid behavior systemat review suicid behavior sb high associ respons stress hypothalam pituitari adren hpa axi aim studi summar result obtain genet studi analyz hpa axi stress pathway sb systemat review | D056726 | T033;T063 |
34,681,001 | investig role common rare variant larg italian multiplex famili multipl sclerosi patient known multipl sclerosi ms suscept variant explain half diseas estim herit wherea low frequenc rare variant may part account miss herit thus sought determin occurr rare function variant larg italian ms multiplex famili five affect member purpos combin linkag analysi next generat sequenc ngs base whole exom whole genom sequenc wes wgs respect genet burden attribut known common ms variant also assess weight genet risk score wgrs found signific higher burden common variant affect famili member compar observ among sporad ms patient healthi control hcs also identifi gene contain least one low frequenc function variant share among affect famili member show signific enrich gene involv specif biolog process particular mrna transport neurodegen diseas altogeth find point possibl pathogen role differ low frequenc function ms variant belong share pathway propos rare variant togeth known common ms variant may account high number affect famili member within ms multiplex famili | D020022 | T032 |
34,681,000 | modul global gene express aneuploidi cnv dosag sensit regulatori gene aneuploidi disrupt genet balanc due partial genom dosag chang usual detriment euploidi variat investig modul gene express aneuploidi analyz transcriptom sequenc data autosom sex chromosom trisomi drosophila result show gene vari chromosom cis present dosag compens remaind genom tran produc widespread invers dosag effect alter function pathway identifi common characterist aneuploidi sever possibl regulatori gene screen invers dosag effect furthermor demonstr dosag chang invers regul inr pcf produc genom wide invers dosag effect find suggest mechan genom imbal relat chang stoichiometr relationship macromolecular complex member affect overal function studi may deepen understand gene express regulatori mechan | D004303 | T045 |
34,680,999 | autism spectrum disord analysi mobil element q william beuren region compar genom autism spectrum disord asd group complex neurodevelopment disord character deficit social interact communic mani genet variant associ asd includ duplic q encompass gene symmetr hemizyg delet q caus william beuren syndrom wbs multisystem disord character hyper sociabl communic skill interest delet four non exon mobil element mes canin wbs locus associ behavior diverg wolf dog dog sociabl domest hypothes indel mes could involv asd associ differ phenotyp use biomark patient stratif therapeut design sinc mes non exon never discov search correspond mes loci human compar genom interest map differ asd relat gene loci individu phenotyp differ autism neurotyp control amplifi pcr sub set amplicon sequenc sanger variant result associ asd neither specif phenotyp found novel small scale insert snps discov sinc mes hyper methyl epigenet modul gene express investig asd necessari | D002872 | T049 |
34,680,997 | genet epigenet chang plant respons abiot stress current global climat crisi led drought high salin abnormaltemperatur heat cold serious threat crop product nbsp | D055864;D013312 | T121;T039;T046;T032;T040;T070 |
34,680,996 | metabolom crop breed general consider develop new product varieti agricultur crop becom increas difficult task modern approach identif benefici allel use elit cultivar quantit trait loci qtl map marker assist select mas effect insuffici keep pace improv wheat crop metabolom power underutil approach assist crop breed review basic methodolog inform summar current strategi applic metabolom relat crop breed explor use recent exampl briefli describ class plant metabolit cellular local metabol pathway strength weak main metabolom techniqu among commerci genet modifi crop alter metabol enzym activ identifi intern servic acquisit agri biotech applic isaaa databas plant review encourag exampl applic knowledg biochem pathway base recent exampl metabolom studi discuss perform metabol marker integr metabol genom data metabol qtls mqtls metabol genom wide associ studi mgwas elucid metabol pathway involv gene help crop breed introgress allel wild relat target manner | D055432;D000069600 | T091;T040 |
34,680,995 | impact abcg gene polymorph predisposit psoriasi psoriasi chronic inflammatori diseas caus interact genet environment factor evid show associ psoriasi co morbid includ cardiovascular diseas metabol syndrom hyperuricemia genom wide associ studi reveal abcg gene encod atp bind cassett g protein associ inflamm higher serum urat concentr studi aim evalu role abcg gene polymorph suscept psoriasi genotyp distribut two abcg singl nucleotid polymorph snps rs rs examin psoriasi patient gender match non psoriasi control found heterozygot gt rs associ decreas risk psoriasi p adjust ci adjust age compar homozygot major allel gg subject carri least one polymorph allel homozygot heterozygot minor allel less suscept psoriasi p adjust ci bear higher serum urat level p homozyg major allel result indic abcg gene polymorph associ risk psoriasi | D056726;D020022 | T033;T032;T063 |
34,680,991 | herit de novo mutat oesophag atresia tracheoesophag fistula aetiolog tracheoesophag fistula tof congenit anomali caus unknown major patient oatof variabl featur mani often mono genet syndrom research use anim model target gene involv candid pathway often result tracheoesophag phenotyp howev limit overlap gene implic anim model found oatof relat syndrom anomali knowledg affect pathway anim model accumul understand pathway patient lag behind affect pathway associ anim patient mechan link genet mutat affect cell type cellular defect phenotyp often well understood locus heterogen uncertainti exact herit oatof result relat low diagnost yield oatof sporad find low famili recurr rate parent usual unaffect de novo domin mutat seem plausibl explan surviv rate patient born oatof increas substanti patient start famili thus detect proper interpret domin inherit pathogen variant great import patient understand oatof aetiolog | D005817;D020022 | T091;T032;T061 |
34,680,990 | expand constel histon post translat modif epigenet landscap emerg nucleosom base chromatin structur accompani evolutionari transit prokaryot eukaryot scenario histon becam heart complex precis time coordin chromatin architectur function adapt respons environment influenc mean epigenet mechan notabl epigenet machineri involv overwhelm number post translat modif multipl residu core linker histon review aim comprehens describ old recent evid excit field research particular histon post translat modif establishingremov mechan genom locat implic nucleosom dynam chromatin base process well harmoni combin interdepend discuss | D019143 | T038 |
34,680,989 | cold shock protein south pole dwell soil bacterium arthrobact sp confer cold toler rice low temperatur critic environment factor restrict physiolog organ across kingdom prokaryot cold shock induc express various gene protein involv cellular process cold shock protein arcspa south pole dwell soil bacterium arthrobact sp introduc rice monocot model plant speci four week old arcspa transgen rice plant grown cold chamber c surviv day cold stress signific decreas chlorophyl content wt plant day compar arcspa transgen plant rna seq analysi perform wt arcspa transgen rice withwithout cold stress go term respons stress go respons cold go respons heat go signific enrich among upregul gene arcspa transgen rice normal condit even without cold stress treatment express five cold stress relat gene rabb osg rab osg lea osg abi os g mapk osg signific upregul transgen rice compar wt rice result indic arcspa gene might involv induct cold respons gene provid cold toler | D000222;D003080;D012988 | T040;T070;T067 |
34,680,988 | identif comprehens structur function analys exo gene famili cotton exo gene vital compon exocytosi complex particip biolog process rang plant cell divis polar growth mani exo gene plant function extens littl known exo gene famili cotton analyz four cotton sequenc databas identifi exo gene divid eight subgroup exoa exoh base phylogenet relationship exoa exon wherea seven one two exon henc exoa may mani import function exo gene asian upland cotton express root stem leav flower fiber andor ovul full length ghexoa cdna homolog clone upland cotton gossypium hirsutum g hirsutum subcellular analysi reveal ghexoa protein local plasma membran yeast two hybrid assay reveal ghexoa interact ghexoa ghexob ghexoc ghexoa silenc signific alter gene chang sever signal pathway relat metabol thus exo gene play critic role physiolog function cotton | D017343 | T028 |
34,680,987 | develop new cancer treatment identifi focus genet mutat alter express gynecolog cancer advent next generat sequenc ngs cancer genom atlas tcga research network given gynecolog cancer molecular classif impact clinic practic new cancer treatment identifi target pathogen abnorm gene rapid develop promin progress gynecolog cancer clinic efficaci poli adp ribos polymeras parp inhibitor shown breakthrough benefit reduc hazard ratio hrs hrs progress death brca mutat ovarian cancer immun checkpoint inhibit also promis cancer harbor mismatch repair defici dmmr microsatellit instabl msi review focus druggabl genet alter gynecolog cancer summar literatur find complet ongo clinic trial | D009154 | T045 |
34,680,986 | identif character hsp gene famili reveal involv hsp grp trap heat stress respons chlami farreri heat shock protein hsps class ubiquit high conserv multi function molecular chaperon present live organ assist protein fold process form function protein present studi three hsp gene cfhsp cfgrp cftrap success identifi genom chlami farreri length cfhsp cfgrp cftrap bp bp bp contain open read frame orf bp bp bp encod protein amino acid respect transcriptom databas demonstr cfhsp cfgrp primari function executor high express larval develop adult tissu cftrap express low furthermor three cfhsps show higher express gonad ganglia compar tissu indic probabl involv gametogenesi nerv signal transmiss c farreri addit heat stress express cfhsp cfgrp signific regul mantl gill blood heart nevertheless express cftrap chang signific four test tissu taken togeth cope heat stress cfhsp cfgrp could help correct protein fold salvag damag protein cell homeostasi c farreri collect comprehens analysi cfhsps c farreri conduct studi indic function divers cfhsps growth develop environment respons find may implic subsequ depth explor hsps invertebr | D018869 | T040;T039 |
34,680,985 | identif express profil circul microrna serum cysticercus pisiformi infect rabbit cysticercus pisiformi c pisiformi larval form taenia pisiformi parasit main liver omentum mesenteri rabbit caus huge econom loss rabbit breed industri microrna mirna short non code rna wide stabli distribut plasma serum numer data demonstr parasit infect mirna becom key regulatori factor control host biolog process howev role serum mirna c pisiformi infect rabbit elucid studi compar mirna express profil c pisiformi infect healthi rabbit serum use rna seq total mirna differenti express fold chang p includ downregul mirna data verifi qrt pcr real time quantit polymeras chain reaction analysi addit go analysi show target gene dysregul mirna enrich cellular singl organ metabol process kegg pathway analysi show mirna target gene involv pik akt viral carcinogenesi b cell receptor signal pathway interest align clean read pisiformi genom four mir p mir p mir novel mir pisiformi deriv mirna found novel mirwa upregul differ period c pisiformi infect verifi qrt pcr pre novel mir amplifi cysticerci rt pcr impli novel mir deriv c pisiformi great potenti diagnosi cysticercosi pisiformi infect first investig mirna express profil function serum rabbit infect c pisiformi provid fundament data develop diagnost target cysticercosi pisiformi | D020869 | T059;T063 |
34,680,983 | genom wide character spl gene famili codonopsi pilosula reveal function cpspl cpspl promot accumul secondari metabolit growth c pilosula hairi root squamosa promot bind protein like spl transcript factor play critic role regul divers aspect plant growth develop includ veget phase chang plant architectur anthocyanin accumul later root growth etc present studi spl gene identifi base genom data codonopsi pilosula well known medicin plant phylogenet analysi cluster cpspls eight group g g along spls arabidopsi thaliana solanum lycopersicum oryza sativa physcomitrella paten cpspls group share similar gene structur conserv motif composit cis act element respond light stress phytohormon wide exist promot region qrt pcr result indic cpspls differenti express differ tissu root stem leaf flower calyx differ development period month germin various condit nacl meja aba treatment compar control overexpress cpspl cpspl signific promot growth hairi root also accumul total saponin lobetyolin result establish foundat investig cpspls provid novel insight biolog function far know first experiment research gene function c pilosula | D018745 | T028 |
34,680,982 | identif valid qtl bacteri leaf streak resist rice oryza sativa l thai xoc strain rice one import food crop world vital import mani countri various diseas caus fungi bacteria virus constant threaten rice plant caus yield loss bacteri leaf streak diseas bls caus xanthomona oryza pv oryzicola xoc one devast rice diseas howev modern rice varieti suscept bls studi appli qtl seq approach use f popul deriv cross ir homcholasit hsc rapid identifi quantit trait loci qtl confer resist bls caus thai xoc isol sp result show singl genom region begin chromosom high associ resist bls gene xa consid potenti candid gene region sinc associ singl nucleotid polymorph snps within gene kompetit allel specif pcr kasp marker develop base two consecut function snps xa valid six f popul inocul anoth thai xoc isol ny phenotyp varianc explain marker pve rang six popul find indic xa viabl candid gene bls resist may help breed program bls resist | D040641 | T028 |
34,680,981 | opportun challeng improv public research program plant breed enhanc underutil plant genet resourc tropic american tropic hotspot wild domest plant biodivers still underutil breed program despit conserv region gene bank improv program depend long term public fund mainten special staff unfortun financi up down complic staff connect research impact agrosavia corporacin colombiana de investigacin agropecuaria dramat decreas public financi support survey research agrosavia involv plant breed plant genet resourc program examin effect decim fund last ten year hypothes staff dedic plant breed still suffer strong fragment low connect expect social network among research weak top ten central leader predomin male msc degre signific experi area staff experi tropic crop list underutil speci moreov although crop nation germplasm bank primari sourc breed program propos five principl improv connect among team research impact promot intern discuss gender gap generat shift design indic monitor decreas dispar time construct long term initi synergi colombian govern support local product food secur crop independ market trend better collabor nation plant germplasm bank plant breed research concert prioriti list speci especi neglect underutil extern institut better focus collabor effort research use public fund better space design project among research train program new technolog principl could also appli tropic countri public plant breed research program face similar challeng | D017343;D000069600;D014329 | T040;T070;T028 |
34,680,980 | dna methyl pig fut promot alter mrna express regul e coli f suscept post wean diarrhea pwd frequent associ e coli f infect piglet howev under molecular mechan concern resist e coli f local wean piglet china clear understood present studi compar analysi transcriptom fucosyltransferas fut evalu key candid correl resist e coli f sutai meishan piglet function analysi demonstr fut act key posit regul e coli f suscept newli food accustom piglet howev core promot fut present bp chr g g compris methyl cpg site among methyl level two cpg site mc mc locat hifa sp transcript factor tf consider associ mrna express fut p find indic methyl mc mc site certain inhibitori effect fut express promot resist e coli f piglet underlin studi may explor fut new candid target e coli f infect chines local wean piglet | D019175;D011401 | T044;T114;T123 |
34,680,978 | compound heterozygot point mutat chromosom microdelet involv otudb coincid zmiz variant syndrom intellectu disabl otudb zmiz gene recent identifi caus syndrom intellectu disabl id share phenotyp facial dysmorph distal limb anomali seizur disord otudb zmiz relat id inherit autosom recess autosom domin pattern respect report year old girl development delay facial phenotyp resembl william syndrom cardiac defect patient also termin broaden finger polydactyli cytogenom microarray cma whole exom sequenc wes mrna analysi perform cma show patern inherit mb delet q chr otudb involv wes identifi hemizyg otudb variant cdela plysasnfst mother heterozyg allel wes also demonstr heterozyg zmiz variant c c patient father zmiz variant yield exon skip evidenc mrna studi suggest william syndrom like phenotyp name periorbit edema hang cheek long smooth philtrum repres expand phenotyp otudb relat id data expand genotyp spectrum otudb zmiz relat disord first report case compound heterozygot featur point mutat chromosom microdelet otudb uniqu event otudb coupl zmiz variant | D020022 | T032 |
34,680,976 | evalu impact sex bias genet admixtur america analysi haplotyp data general imbal proport disembark male femal america document tran atlant slave trade coloni era although less promin recent imbal may left signatur genom modern day popul characteris high level admixtur analysi uniparent system evalu continent proport ratio autosom x chromosom reveal general sex imbal toward male european femal african indigen american ancestri howev consist degre imbal variabl suggest factor cultur social practic may play role shape moreov investig evalu sex imbal use haplotyp data contain critic inform genotyp analys genom wide data admix american individu assess presenc direct magnitud sex bias admixtur america purpos appli two haplotyp base approach elai nnls compar genotyp base method admixtur besid general agreement method unravel post coloni admixtur dynam show higher complex previous describ | D005828;D063426 | T054;T090 |
34,680,974 | genet divers popul structur asian tiger mosquito aed albopictus vietnam evid genet differenti climat region aed albopictus nativ mosquito southeast asia high potenti diseas transmiss understand ae albopictus popul develop speci nativ rang use plan futur control strategi identifi sourc invas rang present studi aim investig genet divers popul structur ae albopictus across various climat region vietnam analyz mitochondri cytochrom oxidas coi gene sequenc specimen collect local use distanc base redund analysi evalu amount variat genet distanc could explain geograph distanc climat factor high level genet polymorph detect haplotyp similar sequenc temper tropic region worldwid note haplotyp group geograph distribut result distinct popul structur northeastern popul remain popul genet differenti notabl genet variat among ae albopictus popul driven primarili climat factor lesser extent also influenc geograph distanc find fill import gap current understand popul genet ae albopictus vietnam especi respect provid data track origin invad region worldwid | D005828;D010802 | T062;T090;T078 |
34,680,972 | covid infect alter microbiom elit athlet sedentari patient similar bacteri flora regular exercis upgrad effici immun system benefici alter composit gastro intestin microbiom test hypothesi activ athlet divers microbiom sedentari subject could provid better protect covid infect twenti activ compet athlet ca male femal nation first second leagu age year sedentari subject sed male femal age year diagnos posit covid pcr test serv subject studi fecal sampl collect five eight day diagnosi three week negat covid pcr test use microbiom analysi except two individu subject report mild andor mild symptom covid stay home quarantin signific differ found bacteri flora train untrain subject hand covid infect phylum level relat abund bacteroidet elev covid compar level measur three week negat pcr test p subject includ statist analysi sinc known bacteroidet suppress toll like receptor ace depend signal thus enhanc resist pro inflammatori cytokin suggest bacteroidet provid protect sever covid infect differ microbiom bacteri flora train untrain subject mild level covid infect | D056352;D000069196;D057185 | T007;T079;T098;T097;T001;T033 |
34,680,971 | dbtrend web server trna express profil small rna sequenc data human transfer rna trna key compon translat machineri play critic role stress condit various diseas knowledg regard import trna function increas biolog role still well understood current comprehens databas web server provid express landscap trnas across varieti human tissu diseas construct user friend interact databas dbtrend provid profil matur trna express across various biolog condit reanalyz small rna microrna sequenc data cancer genom atlas tcga ncbi gene express omnibus geo human user explor express valu matur individu trnas human genom also isodecod isoacceptor base specif pipelin dbtrend provid express pattern trnas differenti express trnas differ biolog condit inform sampl patient tissu type molecular subtyp cancer databas expect help research interest function discoveri trnas | D030541;D020407;D012984 | T090;T170;T073 |
34,680,967 | eukaryot genom show strong evolutionari conserv k mer composit correl contribut intron intergen region sever strong conserv dna sequenc pattern intron intergen region iir consist short tandem repeat strs repeat length bp alreadi describ kingdom animalia work expand search analysi conserv dna sequenc pattern wider rang eukaryot genom aim confirm conserv pattern support hypothesi function constraint andor identif unknown pattern pairwis compar genom dna sequenc gene exon cds intron intergen region embryophyta land plant protista fungi use establish k mer base align free comparison method addit result compar valu deriv animalia former studi confirm strong correl sequenc structur iir span entir domain eukaryot found high correl within intron intergen region two result conserv abund strs repeat unit bp eg n sequenc pattern invers complementari sequenc found violat equal distribut complementari dna strand subset genom look mismatch within identifi str pattern found specif prefer certain nucleotid stabl four phylogenet kingdom conclud conserv pattern iir indic share function sequenc structur relat strs | D019143 | T038 |
34,680,966 | angiotensin convert enzym ace gene polymorph phenotyp express covid symptom renin angiotensin aldosteron system raa appear play import role sar cov infect polymorph within gene control enzymat system candid elucid pathogenesi covid sinc covid pulmonari diseas also affect mani organ system throughout bodi multipl way strike fact ace one major compon raa prerequisit sar cov infect recent group report associ polymorph ace gene homolog ace phenotyp express covid particular sever ethnic differ ace insert delet polymorph seem explain appar differ mortal west east asia purpos review evalu evid link ace polymorph covid search medlin databas refer citat relev articl select studi clinic outcom covid relat ace id polymorph although number patient larg enough yet avail evid support notion dd genotyp advers influenc covid symptom surpris small studi conduct sever countri yield opposit result suggest ace ii genotyp risk factor contradictori result may case certain geograph area especi subgroup patient may also due interact gene yet unexplain biochem mechan accord hypothesi candid gene function involv pathophysiolog covid act concert ace dd genotyp show differ frequenc west east asia conduct research focus alu relat gene current studi ace genotyp provid potenti new clue pathogenesi treatment diagnosi sar cov infect | D000086382;D015967;D005838;D054643;D007703;D011110 | T116;T047;T045;T129;T032;T067;T126 |
34,680,962 | complet mitochondri genom one breed strain asian swamp eel monopterus albus zuiew use pacbio illumina sequenc technolog phylogenet analysi synbranchiform asian swamp eel monopterus albus zuiew commerci import fish due nutrit valu eastern southeastern asia one local strain albus distribut jianghan plain china subject select breed program prefer bodi color superior growth fecund member genus monopterus reclassifi genera recent classif requir phylogenet analys studi complet mitochondri genom breed albus decod use pacbio illumina sequenc technolog phylogenet analys carri includ sampl albus five differ site speci synbranchiform complet mitochondri genom total length mitogenom bp one nucleotid shorter four mitogenom albus sampl four provinc china well one unknown sampl site gene content gene order overal base composit almost ident five report one result maximum likelihood ml bayesian infer analys complet mitochondri genom protein code gene pcgs consist phylogenet tree indic select breed form deepest branch clade asian swamp eel confirm phylogenet relationship four genera famili synbranchida also provid systemat phylogenet relationship order synbranchiform diverg time analys show asian swamp eel diverg million year ago mya common ancestor split speci mya middl miocen epoch altogeth complet mitogenom breed albus would serv import dataset germplasm identif breed program speci addit provid great help identifi phylogenet relationship order synbranchiform | D010802 | T062;T078 |
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