PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,677,694 | enhanc osteoblast differenti small molecul incorpor engin nanofibr scaffold studi aim investig effect small molecul incorpor engin nanofibr scaffold enhanc osteoblast differenti materi method poli caprolacton pcl nanofib matric lithium chlorid licl fabric use electrospin techniqu scaffold character use scan electron microscopi sem energi dispers x ray edx scaffold seed mct e cell assess use western blot catenin alamarblu assay prolifer qpcr osteoblast differenti miner alizarin red stain | D057139;D010012 | T042;T073 |
34,677,693 | differenti leukocyt microrna respons follow pan cell allorecognit allosecretom base therapeut activ effect immunomodul cell respons critic treat autoimmun diseas cancer previous studi demonstr secretom deriv control methoxypolyethylen glycol mix lymphocyt alloactiv assay exert potent immunomodulatori activ mediat microrna mirna immunomodulatori effect biomanufactur mirna base allo secretom therapeut syn ta ia ia compar pan cell activ pha anti cdcd lymphocyt alloactiv differenti effect activ strategi rest peripher blood mononuclear cell pbmc assess via cell prolifer subset analysi mirna express profil mitogen induc pbmc prolifer signific exceed aris either allostimul pro inflammatori ia secretom product consequ stimul ratio cd cd cell rest pbmc cd cd decreas pan cell allrecognit ia activ cell averag chang aros consequ expans cd cd cd cd popul well shrinkag cd subset expans cd cell import activ strategi induc vast differ mirna express profil associ signific differ cellular differenti biolog function find support concept differenti pattern mirna express regul biolog immun respons lock key manner biomanufactur mirna enrich secretom biotherapeut may success therapeut approach system treatment autoimmun diseas ta cancer ia | D007963;D035683 | T025;T114;T123 |
34,677,692 | surgic treatment esophag cancer new technolog modern concept germani esophag cancer most treat special center accord nation intern guidelin multimod interdisciplinari set next year central esophag surgeri continu germani due new nation regul minimum case volum articl highlight new technolog surgic treatment esophag cancer also depict current oncolog concept perspect high volum center | D004938;D010535 | T061;T191;T060 |
34,677,690 | silag ferment characterist microbi divers alfalfa medicago sativa l respons exogen microbiota temper grass object studi explor microbiolog factor caus differ silag ferment characterist grass legum specif effect epiphyt microbiota alfalfa oat italian ryegrass ensil characterist microbi communiti alfalfa assess ray irradi steril microbiota transplant technolog steril alfalfa inocul follow asept water stal ii epiphyt bacteria alfalfa alal iii epiphyt bacteria oat alot iv epiphyt bacteria italian ryegrass alir alfalfa initi flower stage ensil laboratori scale silo day compar alal alir higher lactic acid content ratio lactic acid acet acid lower acet acid propion acid ethanol ammonia nitrogen content observ alot day ferment treat group lactobacillus domin genus day ensil relat higher abund weissella hafnia obesumbacterium enterobacteriacea hetero ferment lactobacillus found alal alir day co occurr network analysi prove pediococcus lactococcus pivot decid ferment pattern alfalfa silag accord rrna gene predict function profil metabol amino acid inhibit epiphyt microbiota oat overal alot show homo ferment process wherea alal alir exhibit hetero ferment pattern furthermor exogen microorgan inhibit metabol amino acid good potenti sourc improv silag qualiti legum forag | D005285 | T044 |
34,677,689 | ecosystem servic impact industri pollut urban health evid durgapur west bengal india industri urban rapid socioeconom growth prime factor regard develop urban citi activ deterior environ slowli increas harm pollut impact observ near futur term sever natur calam diseas ecolog consequ various urban ecosystem like urban forestri wetland grassland parksgarden etc main criteria urban health respect deliv multipl benefit surround biota regulatori system affect sever differ industri pollut stress result deterior physicochem qualiti biotic divers studi reveal annual averag air pollut index api exceed higher threshold valu ie studi period recogn durgapur sever pollut region west bengal india characterist major air pollut like nox suspend particul matter spm tempor trend evalu object studi detect effect industri pollut aforesaid urban ecosystem term variabl ecolog servic purif pollut air atmospher regul reduct nois proper drainag rainwat sewag treatment outcom review work evalu thorough physiolog biochem morpholog symptom plant speci air pollut stress hand effect air pollut human anim popul regard various diseas like bronchiti cardiopulmonari arrest cancer liver kidney dysfunct also discuss | D000393;D000397 | T131;T069;T080 |
34,677,686 | radiograph marker breast cancer brain metastas relat clinic characterist postop outcom occurr brain metastas bm associ poor prognosi patient breast cancer bc magnet reson imag mri standard care diagnosi bm determin treatment strategi aim present studi evalu associ radiograph marker bcbm mri patient characterist overal surviv os | D001932;D001943 | T191 |
34,677,685 | systemat review meta analysi tumour microsatellit instabl status predictor respons fluorouracil base adjuv chemotherapi colorect cancer colorect cancer crc classifi accord chromosom instabl pathway microsatellit stabl mss pathway microsatellit instabl msi pathway adjuv therapi surgeri advanc crc usual base fluoropyrimidin fluorouracil fu alon combin agent controversi howev remain use fu base regimen treat msi relat tumour | D015179;D053842 | T049;T191 |
34,677,683 | identifi skeleton collect vora import forens scienc bioarchaeolog southern inland portug import refer osteolog collect unquestion howev develop methodolog reliabl closer collect socioeconom demograph genet popul studi purpos studi character contextu new portugues refer collect collect identifi skeleton univers vora compris adult sex seven non adult deceas born consist almost exclus individu born die inland alentejo portugues collect characterist collect built follow current legal ethic oblig due characterist collect constitut fundament tool forens bioarchaeolog research inland region portug addit possibl offer develop valid methodolog scienc avail complet hospit archiv research make collect uniqu health studi epidemiolog transit | D001106;D018732 | T091;T060;T090 |
34,677,681 | boron intak decreas risk mortal kidney transplant recipi search potenti modifi factor improv long term outcom among kidney transplant recipi ktr hypothes boron exposur associ improv long term outcom ktr | D001895;D016030 | T061;T196 |
34,677,679 | potenti metagenom next generat sequenc diagnosi spinal infect retrospect studi metagenom next generat sequenc mngs new approach identifi infect organ infecti diseas aim evalu accuraci mngs determin etiolog spinal infect | D059014;D056186 | T091;T059;T063 |
34,677,678 | analysi pulmonari function patient undergo vertebr bodi tether adolesc idiopath scoliosi literatur concern effect scoliosi correct pulmonari function pf scarc sole relat spinal fusion vertebr bodi tether vbt repres new option scoliosi correct howev effect pf yet investig vbt fusion less techniqu limit dynam chest wall expect negat impact pf despit anterior surgic approach | D007738;D012600;D013123 | T190;T047;T061 |
34,677,677 | new bipartit begomovirus natur infect pyrenacantha sp mozambiqu begomovirus isol pyrenacantha sp plant yellow mosaic symptom collect maiz product field mozambiqu complet dna dna b compon genom organ typic old world bipartit begomovirus base current ictv speci demarc criteria genus begomovirus virus isol name pyrenacantha yellow mosaic virus pyymv member new speci name begomovirus pyrenacantha propos align common region cr indic nt insert dna cr nt sequenc ident crs increas nt insert remov align first report begomovirus natur infect pyrenacantha spp | D053839 | T005 |
34,677,676 | pathway microbiom modif relat surgeri enterocol hirschsprung diseas hirschsprung diseas hscr congenit anomali enter nervous system abnorm microbiom composit report hscr patient studi address analyz microbiom modif relat tosurgeri hscr associ enterocol haec | D017615;D004760;D006627;D064307 | T047;T022;T001;T032;T019;T028 |
34,677,674 | view mechanist model chlorella vulgari incub shake flask kinet growth model use tool better understand microalg cultiv optim cultiv condit evalu model requir experiment data labori generat bioreactor set experiment shake flask set use studi allow run experi time individu light intens light durat way biomass data set generat cultiv microalga chlorella vulgari identifi model paramet stepwis paramet estim procedur appli first light associ model paramet estim use addit measur local light intens differ height within medium differ biomass concentr next substrat relat model paramet estim use experi biomass nitrat data provid afterward growth relat model paramet estim applic extens cross valid procedur | D019149;D008954 | T074;T075 |
34,677,673 | frequenc spectrum glucokinas mutat adult maltes popul investig frequenc spectrum glucokinas gck mutat cohort adult island popul high preval diabet mellitus dm | D003924;D005941 | T116;T047;T126 |
34,677,668 | predict nomogram two year growth ct indetermin small pulmonari nodul lung cancer common cancer lead caus cancer relat death worldwid optim manag comput tomographi ct indetermin pulmonari nodul import optim individu follow strategi develop radiom nomogram predict year growth case indetermin small pulmonari nodul | D008175;D055613 | T033;T191 |
34,677,667 | molecular genet divers primari hemophagocyt lymphohistiocytosi among polish pediatr patient hemophagocyt lymphohistiocytosi hlh clinic syndrom life threaten inflamm caus excess prolong ineffect immun respons increas number hlh case recogn poland genet caus famili hlh fhl report investig molecular genet associ outcom pediatr patient met hlh criteria studi patient hlh receiv genet studi twenti five patient subject direct sequenc prf uncd stx xiap shda gene addit patient subject target next generat sequenc studi group patient diagnos primari hlh bi allel fhl variant identifi patient wherea hemizyg chang identifi patient x link lymphoprolif diseas addit one patient diagnos x link immunodefici magnesium defect epstein barr virus infect neoplasia due hemizyg magt variant anoth newborn diagnos auto inflammatori syndrom caus mvk variant major fhl patient carri uncd pathogen variant wherea prf variant occur two patient novel variant uncd prf xiap detect epstein barr virus common trigger note patient secondari hlh three patient secondari hlh heterozyg variant fhl gene found overal surviv entir studi group median year follow result highlight divers molecular caus primari hlh poland | D020031;D051359 | T047 |
34,677,666 | fizz biomark acut exacerb chronic obstruct pulmonari diseas found inflammatori zone fizz associ lung inflamm aim studi investig express util fizz marker chronic obstruct pulmonari diseas copd | D029424 | T047 |
34,677,665 | updat distribut host spectrum dirofilaria repen republ uzbekistan among zoonot mosquito born nematod dirofilaria repen dirofilaria immiti spirurida onchocercida high signific public health perspect immiti also major veterinari concern repen regard less pathogen carnivor main causat agent human dirofilariosi throughout old world republ uzbekistan recent data refer exclus immiti infect domest wild carnivor current preval distribut repen remain unknown total domest wild carnivor carcass collect examin necropsi subcutan nematod collect identifi morpholog overal preval repen infect domest dog cani familiari wildlif host golden jackal cani aureus wolv cani lupus red fox vulp vulp jungl cat feli chaus addit human case subcutan repen infect also document present studi repres first recent assess occurr zoonot filarioid repen republ uzbekistan indic wide distribut domest dog four speci wildlif host throughout countri rais awar public health risk associ parasit | D004183;D060348;D004184;D004283 | T204;T047 |
34,677,664 | sar cov seropreval children famili member juli octob brussel aim studi estim seropreval sar cov antibodi pediatr popul first pandem wave belgium patient requir blood sampl juli octob institut invit particip parent sibl could also particip estim famili transmiss congruenc serolog status questionnair complet particip identifi symptom consist covid previous month blood sampl test sar cov specif immunoglobulin g use elisa final popul includ children sibl children adult seropreval case septemb date correspond week begin second wave belgium afterward ci p valu twenti five percent children asymptomat none experienc sever diseas symptom associ sar cov posit antibodi diarrhoea ci p valu fever ci p valu rhiniti ci p valu anosmia ci p valu child first symptomat household member famili clustersconclus seropreval children compar general popul children could repres sourc infect household known covid infect general mild asymptomat children adolesc belgian strategi test focus symptom adult believ respons famili cluster new serolog test give accur view rate infect children base serolog result children infect frequent adult first second wave belgium seventi five percent sar cov igg posit children present mild symptomatolog total asymptomat children could repres sourc infect within household | D000086382;D000086402 | T047;T005;T067 |
34,677,661 | comparison differ prognost model use metastat bone diseas appendicular skeleton chilean popul sever preoper prognosi model use treatment metastat bone diseas appendicular skeleton devis purpos studi compar perform differ surviv prognost model patient metastat bone diseas long bone chilean popul | D001859 | T191 |
34,677,660 | citi scale energet window adapt thermal insul north american citi previous research demonstr citi similar individu mammal relationship rate energi use heat outdoor air temperatur requir heat indoor live space energi plot citi contain inform citi wide thermal insul make possibl quantifi citi wide use citi unit measur develop method extract insul inform deriv method prior research mammal use method address question north america citi built particular cold locat construct way provid greater thermal insul one built thermal moder locat use data small medium size citi two inform extract method find statist signific invers relationship citi wide year averag citi recent year period rang year c relationship repres energi conserv trend indic citi cold climat greater built thermal insul citi warm climat howev augment insul cold climat half great would requir offset fulli increas energi cost low cold climat year explain varianc measur insul suggest citi north america vari great extent thermal insul prioriti citi develop | D002980;D003080 | T070 |
34,677,659 | characterist patient atrial flutter spontan atrioventricular conduct without anti arrhythm drug treatment atrial flutter afl larg reentrant circuit locat right atrium anti arrhythm drug aad provok afl atrioventricular conduct avc caus hemodynam collaps elucid characterist patient afl exhibit spontan avc fifteen patient afl group male year old document afl avc enrol compar patient without avc control group male year old afl cycl length maximum avc signific longer afl group control group vs ms p among avc group patient aad afl cycl length signific longer avc compar avc document day vs ms p suggest enhanc effect aad avc remain patient take aad patient show enlarg tricuspid annulus patient develop avc exercis multivari analysi reveal younger age use aad independ risk factor develop afl group prolong afl cycl length associ class iaic aad use slower heart rate sinus rhythm younger age import risk factor develop avc afl | D000889;D001282 | T046;T121 |
34,677,658 | right ventricular contractil affect clinic efficaci add tolvaptan follow hospit heart failur patient signific tricuspid regurgit tricuspid regurgit tr common condit independ associ high mortal rate patient heart failur hf sever studi demonstr clinic efficaci add tolvaptan patient hospit hf howev effect add tolvaptan patient signific tr less well understood among patient moder sever tr assess transthorac echocardiographi hospit congest hf patient could complet clinic cours start add tolvaptan includ studi rehospit due hf cardiac death defin advers cardiac event studi investig presenc absenc cardiac event within year follow introduct tolvaptan evalu echocardiograph function paramet associ cardiac event averag patient age year patient experienc advers cardiac event within year add tolvaptan administr serum creatinin mgdl brain natriuret peptid pgml concentr discharg signific higher patient cardiac event without cardiac event vs p vs p respect presenc absenc past hospit hf also signific higher event posit group compar event free group vs p comparison echocardiograph paramet reveal patient cardiac event signific lower left ventricular eject fraction vs p lower right ventricular fraction area chang rvfac vs p without cardiac event multipl logist regress analysi reveal rvfac past hospit hf independ associ cardiac event follow introduct tolvaptan odd ratio p respect right ventricular contractil well past histori admiss hf left ventricular eject fraction renal function brain natriuret peptid level discharg may reflect clinic outcom hf hospit patient signific tr treat tolvaptan | D006333;D014262 | T047;T046 |
34,677,657 | impact nocturn hypoxemia recurr atrial tachyarrhythmia cathet ablat atrial fibril factor caus atrial tachyarrhythmia recurr cathet ablat ca atrial fibril af remain undetermin studi aim investig effect nocturn hypoxemia recurr atrial tachyarrhythmia ca af among patient af underw ambulatori sleep studi nation cerebr cardiovascular center suita osaka japan underw ca af patient underw ca follow month multivari cox regress analysi use calcul hazard ratio hrs use clinic variabl identifi independ predictor atrial tachyarrhythmia recurr final ca atrial tachyarrhythmia recur patient median follow period day interquartil rang perform multivari analysi data patient receiv continu posit airway pressur cpap sever nocturn hypoxemia defin percentag sleep time spent sao hr confid interv ci p mlm increas left atrial volum index hr ci p found independ associ recurr atrial tachyarrhythmia addit rate freedom atrial tachyarrhythmia final af ablat cpap signific lower group sever nocturn hypoxemia log rank p conclus necessari consid ahi nocturn hypoxia perform ambulatori sleep apnea studi ca may less effect patient sever nocturn hypoxia despit administr cpap | D001281;D017115 | T047;T061;T046 |
34,677,656 | pamidron therapi increas trabecular bone complex mandibular condyl individu osteogenesi imperfecta patient osteogenesi imperfecta oi present extra skelet manifest includ import orodent craniofaci featur dentinogenesi imperfecta dental agenesi failur maxilla growth hypotonia masticatori muscl featur may compromis vital function speech mastic studi demonstr cyclic pamidron infus standard therapi patient moder sever oi influenc histomorphometr pattern differ bodi bone present studi aim investig condyl trabecular bone pattern oi patient use fractal dimens fd analysi dental panoram radiograph imag character mandibular condyl trabecular bone adolesc diagnos oi treat pamidron imag exam adolesc sex age year analyz compar age sex match healthi adolesc fd patient signific lower healthi control p type oi age treatment onset durat therapi variabl show statist signific effect fd result studi demonstr bone architectur mandibular condyl may alter pediatr patient moder sever form oi also pamidron treatment seem posit effect condyl trabecular bone patient support find fd valu posit influenc length cyclic pamidron treatment time imag well age individu treatment onset | D010013 | T047 |
34,677,655 | work characterist acut care surgeon swiss tertiari care hospit prospect one month snapshot studi multipl acut care surgeri ac work model implement optim resourc call roster knowledg work characterist requir therefor studi aim investig daili work characterist ac surgeon swiss tertiari care hospit | D066231 | T097 |
34,677,650 | risk factor characterist bacteri infect first line chemotherapi metastat gastric gastroesophag junction adenocarcinoma chemotherapi relat bacteri infect common side effect patient receiv chemotherapi purpos studi determin risk factor characterist bacteri infect metastat gastric gastroesophag junction gej adenocarcinoma patient treat combin chemotherapi | D000230;D001424;D004938;D013274 | T191;T047 |
34,677,649 | prognost nutrit index dynam curat treatment independ prognost factor surviv non metastat nasopharyng carcinoma aim identifi prognost predict valu post treatment prognost nutrit index pni pni dynam nasopharyng cancer patient npc studi | D009303;D015596 | T191;T170;T060;T081 |
34,677,647 | efficaci safeti wilm tumor helper peptid ocv elder patient acut myeloid leukemia multicent random doubl blind placebo control phase trial complet remiss cr acut myeloid leukemia aml elder patient short durat suitabl post remiss therapi explor role wilm tumor helper peptid ocv prevent recurr remiss | D015470;D025721 | T191;T116;T123 |
34,677,646 | mirna profil diseas sever patient sickl cell anemia identif biomark associ sever sickl cell anemia desir circul serum microrna mirna target studi diagnost prognost marker studi conduct sickl cell anemia purpos studi identifi specif signatur mirna plasma sampl sickl cell anemia patient accord sever index screen mirna express perform patient classifi tricuspid regurgit veloc trv measur trv ms trv ms sampl analyz real time pcr use megaplex rt human pool pool b compris distinct mirna seventeen mirna differenti express two group p five differenti express mirna mirb mir mir mir mir select valid cohort patient sampl trv ms anoth two sever score also use organ injuri score oi bayesian score bs univari binari logist regress perform analyz data five differenti express mirna select valid patient sampl mirb mir mir mir mir two mirna mir mir signific decreas case greater sever wherea mir express discrimin patient accord trv oi mir express accord bs first studi investig plasma mirna possibl biomark sca sever data suggest low level mir mir express associ greater sca diseas sever studi still necessari elucid mechan mirna relat protein | D059467 | T086;T081 |
34,677,642 | mr find suggest idiopath intracrani hypertens patient spontan cerebrospin fluid rhinorrhea purpos studi document preval mr find suggest idiopath intracrani hypertens iih patient undergo endoscop repair spontan csf rhinorrhea scsfr | D002559;D019586;D010211;D011559 | T033;T047;T037;T046 |
34,677,641 | inferior base dermoglandular flap partial subpector implant transposit revis mastopexi subglandular breast augment complic revis augment mastopexi complex procedur aim correct complic previous surgeri purpos studi evalu reliabl inferior base dermoglandular flap partial subpector implant coverag correct implant tissu relat complic associ primari subglandular breast augment influenc improv outcom | D018427;D016462 | T074;T061 |
34,677,638 | localis cryptochrom avian retina cryptochrom photolyas relat blue light receptor act core compon mammalian circadian clock cell nuclei one member cryptochrom protein famili also assum play role avian magnetorecept primari sensori molecul retina migratori bird mediat light depend magnet compass orient still identifi mrna cryptochrom cri report locat cell nuclei retina cri localis yet demonstr protein level provid evid cri protein locat photoreceptor inner segment outer nuclear layer inner nuclear layer ganglion cell layer retina night migratori european robin home pigeon domest chicken subcellular level find cri cytoplasm nucleus cell resid layer broad nucleic express rather point role avian cri circadian clock consist function transcript factor analog mammalian cri speak involv magnetorecept | D056931;D020308 | T116;T012;T123 |
34,677,637 | magnetosens learn walk desert ant cataglyphi nodus begin forag career cataglyphi desert ant calibr compass system learn visual panorama surround nest entranc perform well structur initi learn walk rotat bodi movement pirouett nave ant novic gaze back nest entranc memor way back nest align gaze direct reli geomagnet field compass cue contrast experienc ant forag use celesti compass cue path integr food search panorama nest entranc chang forag perform learn walk prior head new forag excurs show initi learn walk learn walk structur differ learn walk forag circl around nest entranc leav nest area search food pirouett gaze back nest entranc addit forag use magnet field compass cue align gaze direct learn walk pirouett nevertheless magnet alter learn walk manipul panoram condit induc chang nest direct view indic forag still magnetosensit cue conflict situat | D001000 | T204 |
34,677,634 | intraop periprosthet occult fractur acetabulum affect clinic outcom primari total hip arthroplasti frequenc intraop periprosthet occult fractur acetabulum ipoa primari total hip arthroplasti tha relat high howev effect fractur clinic outcom surviv primari tha remain unknown studi aim determin impact ipoa outcom primari tha minimum follow year | D019644;D005596;D006620;D006622;D057068;D016103 | T037;T047;T074;T061 |
34,677,633 | spinal patholog outcom post tha segment arthrodesi matter presenc lumbar spine arthrodesi sa associ abnorm spinopelv characterist inferior outcom post total hip arthroplasti tha howev whether patient upper segment sa also increas risk complic unknown studi aim determin upper segment sa associ inferior tha outcom assess spino pelvic characterist test whether static dynam spinopelv characterist correl outcom post tha | D019644;D004204;D013123 | T037;T061 |
34,677,632 | detect epimuscular myofasci forc golgi tendon organ skelet muscl emb multipl tendon organ proxim distal end muscl fiber one function spatial distribut may provid local uniqu forc feedback may becom import stress distribut non uniform within muscl forc exert connect adjac muscl ie epimuscular myofasci forc may caus local differ forc aim exploratori studi investig effect mechan interact adjac muscl sensori encod tendon organ action potenti singl affer record intra axon respons ramp hold releas rhr stretch passiv agonist muscl differ length relat posit passiv synergist tendon gastrocnemius gas plantari pl soleus muscl cut skeleton attach servomotor connect tissu among muscl kept intact lengthen gas pl decreas forc threshold tendon organ p forc threshold later gastrocnemius lg tendon organ affect length p also displac lg pl kept constant muscl tendon unit length proxim distal posit result decreas forc threshold lg tendon organ p result indic tendon organ fire affect chang length andor relat posit adjac synergist muscl conclud tendon organ provid central nervous system inform local stress caus epimuscular myofasci forc | D018482;D013710 | T023;T024 |
34,677,631 | estim reduct us mortal cigarett larg replac e cigarett recent estim indic substanti replac cigarett e cigarett would reduc us death life year lost million optimist scenario pessimist provid addit insight use altern model base shorter period four main smoke associ diseas death age year full product histori consid variat assum effect dose e cigarett versus cigarett f relat quit rate q proport smoke year x initi rate vape relat smoke | D066300;D016540;D062789;D000072137 | T131;T109;T073;T055 |
34,677,630 | deoxynivalenol induc apoptosi autophagi human prostat epitheli cell via pikakt signal pathway phosphoinositid kinas pik protein kinas b akt signal pathway one deregul signal pathway prostat cancer control basic process cell cell prolifer death disturb balanc cell death surviv might result carcinogenesi deoxynivalenol one common mycotoxin toxic metabolit fungi present everyday diet feed although previous studi report induc oxid stress modul steroidogenesi dna damag cell cycl modul trigger togeth toxic effect normal prostat epitheli cell known aim studi evalu effect apoptosi autophagi normal prostat epitheli cell via modul pikakt signal pathway result show dose induc oxid stress dna damag cell cycl arrest gm cell cycl phase higher concentr induc apoptosi wherea lower one autophagi pnta cell indic modul pikakt result induct autophagi trigger apoptosi normal prostat epitheli cell | D058539;D019869 | T116;T126 |
34,677,629 | use tourniquet superior tourniquet use high tibial osteotomi prospect randomis control trial tourniquet routin use high tibial osteotomi hto howev research necess tourniquet hto lack studi design investig necess tourniquet hto | D019645;D014111 | T074;T061 |
34,677,628 | intern model toward metacognit ai sever paper publish biolog cybernet kawato colleagu propos comput model explain intern model acquir cerebellum model later support neurophysiolog experi use monkey neuroimag experi involv human earli studi influenc neurosci basic sensori motor control higher cognit function one perplex enigma relat intern model understand neural mechan enabl anim learn larg dimension problem trial conscious metacognit abil monitor one thought may part solut enigma base literatur review past year propos comput neurosci model metacognit model compris modular hierarch reinforc learn architectur parallel layer generat invers model pair prefront cortex distribut execut network call cognit realiti monitor network crmn orchestr conscious involv generat invers model pair percept action base mismatch comput generat invers model well reward predict error crmn comput respons signal gate select learn pair percept action reinforc learn high respons signal given pair best captur extern world compet movement small mismatch capabl reinforc learn small reward predict error crmn select pair higher respons signal object metacognit conscious determin entropi respons signal across pair model could lead new generat ai exhibit metacognit conscious dimens reduct select modul correspond represent learn small sampl may also lead develop new scientif paradigm enabl causal studi conscious combin crmn decod neurofeedback | D000067489 | T041 |
34,677,627 | map covari brain fdg uptak structur connect inter subject covari region f fluorodeoxyglucos fdg pet measur fdg cov proxi brain connect gain increas accept communiti yet still unclear extent fdg cov under actual structur connect via white matter fiber tract studi quantifi degre spatial overlap fdg cov structur connect network | D019788;D066127 | T130;T023;T024;T109 |
34,677,626 | cu label daratumumab f ab fragment enabl earli visual cd posit lymphoma abnorm cd express hematolog malign includ lymphoma made biomark target therapi daratumumab dara first fda approv cd specif monoclon antibodi enabl success immunopet imag past year radiolabel dara howev long blood circul delay tumor uptak limit applic focus studi develop cu label dara f ab visual cd lymphoma model | D000911;D008223 | T129;T191;T116 |
34,677,624 | imag diagnosi cholecyst adult ed compar multi reader multivari analysi ct us imag featur purpos studi util multivari logist regress order evalu imag featur combin predict diagnosi cholecyst comput tomographi ct ultrasound us adult ed patient use result compar accuraci ct us | D002764 | T047 |
34,677,621 | low grade osteoarthr develop latarjet procedur minimum year follow systemat review pool analysi purpos systemat review pool analysi evalu incid risk factor glenohumer osteoarthr oa patient underw latarjet procedur minimum year follow | D004204;D007593;D010003;D012783;D012785 | T023;T047;T037;T033;T030 |
34,677,620 | transfus strategi bleed critic ill adult clinic practic guidelin european societi intens care medicin develop evid base clinic practic recommend regard transfus practic transfus bleed critic ill adult | D003422;D016638 | T058;T047 |
34,677,617 | theoret practic consider use retroel insert estim speci tree anomali zone potenti shortcom concaten method speci tree estim failur account incomplet lineag sort coalesc method address problem make various assumpt violat result wors perform concaten given challeng analyz dna sequenc concaten coalesc method retroel insert ris emerg power phylogenom marker speci tree estim show two recent propos quartet base method sdpquartet astralbp statist consist estim unroot speci tree topolog coalesc ris follow neutral infinit site model mutat expect number new ris per generat constant across speci tree accuraci method infer speci tree ris yet assess simul data set true speci tree topolog known therefor evalu eight method given ris simul four model speci tree short branch least three anomali zone simul studi astralbp sdpquartet alway recov correct speci tree topolog given suffici larg number ris predict distanc base method astridbp dollo parsimoni also perform well recov speci tree topolog contrast unord polymorph camin sokal parsimoni well approach base mdc typic fail recov correct speci tree topolog anomali zone situat four ingroup taxa method studi astralbp automat estim intern branch length coalesc unit support valu ie local posterior probabl examin accuraci branch length estim find estim length accur short branch upward bias otherwis led us deriv maximum likelihood branch length estim ris given input instead binari gene tree correct formula produc accur estim branch length simul studi provid suffici larg number ris given input last evalu impact data quantiti speci tree estim repeat experi input size vari parsimoni inform ris found given parsimoni inform ris input astralbp success reconstruct major clade ie clade separ branch coalesc unit high support identifi rapid radiat ie shorter connect branch although precis branch order local posterior probabl effect control fals posit branch scenario coalesc incomplet lineag sort laurasiatheria palaeognatha parsimoni polymorph parsimoni retroel insert speci tree transposon | D046108;D018626 | T123;T114;T012 |
34,677,616 | blood neurofila light chain potenti biomark central peripher nervous toxic rat neurotox princip concern nonclin drug develop howev standard univers accept fluid biomark evalu neurotox lack increas clinic evid support potenti use neurofila light nfl chain biomark sever neurodegen diseas therefor investig chang cerebrospin fluid csf serum level nfl spragu dawley rat treat central nervous system cns toxic trimethyltin tmt mgkg po singl dose kainic acid ka mgkg sc singl dose mk mgkg sc singl dose peripher nervous system pns toxic pyridoxin mgkgday day anim euthan day day day administr day increas serum nfl observ tmt ka treat anim indic neuron cell death brain day andor mk treat anim exhibit chang serum csf level nfl histopatholog chang brain time point pyridoxin induc chromatolysi dorsal root ganglion day degener peripher nerv fiber day addit serum nfl increas strong correl observ serum csf level nfl brain lesion caus tmt ka indic nfl could use biomark detect cns toxic addit pns chang correl serum nfl level therefor serum nfl could serv use peripher biomark detect cns pns toxic rat | D007382;D010525 | T026;T023;T024 |
34,677,613 | aspergillosi emerg risk group critic ill patient inform invas aspergillosi ia invas filament fungal infect limit non neutropen patient admit intens care unit icu present classic ia risk factor review base critic apprais relev literatur author experi discuss took place consensus confer aim review risk factor favor aspergillosi icu patient special emphasi often overlook neglect condit icu patient corticosteroid use treat under condit chronic obstruct pulmonari diseas copd sepsi sever covid repres cardin risk factor ia import addit host risk factor copd decompens cirrhosi liver failur sever viral pneumonia influenza covid clinic observ indic patient admit icu sepsi acut respiratori distress syndrom like develop probabl proven ia suggest sepsi could also possibl direct risk factor ia could small molecul inhibitor use oncolog recommend prophylaxi icu patient posaconazol mold activ primari prophylaxi use center accord guidelin patient popul ia treatment critic ill patient basic patient popul combin evalu clinic sign imag classic biomark gm assay fungal cultur examin remain best option assess respons treatment | D001228 | T047 |
34,677,609 | effect transcrani direct current brain stimul motor cortex chemotherapi induc nausea vomit femal patient breast cancer chemotherapi induc nausea vomit cinv advers outcom associ chemotherapi sometim difficult manag studi aim examin impact singl session transcrani direct current brain stimul tdcs motor cortex minut chemotherapi patient receiv high emetogen chemotherapi | D000932;D000970;D001943;D009044;D065908 | T191;T023;T121;T109;T039;T061;T029 |
34,677,608 | endogen leptin concentr poor predict metreleptin respons patient partial lipodystrophi leptin replac metreleptin improv glycemia hypertriglyceridemia sever hypoleptinem patient general lipodystrophi gld effect variabl partial leptin defici patient partial lipodystrophi pld | D020738;D008060 | T116;T047;T125 |
34,677,607 | chromosom level genom assembl nephotettix cincticep uhler hemiptera cicadellida deltocephalina green rice leafhopp nephotettix cincticep uhler import rice pest vector rice dwarf virus asia produc high qualiti chromosom level genom assembl mb use pacbio hi c data contain scaffold contig whose scaffoldcontig n length reach mb mb assembl anchor eight pseudochromosom genom complet attain accord insect refer benchmark univers singl copi ortholog busco gene set n mask mb genom repetit element nine hundr sixti two noncod rnas identifi protein code gene predict also assign go term kegg pathway annot gene respect signific expand gene famili primarili involv immun cuticl digest detoxif embryon develop studi provid crucial genom resourc better understand biolog evolut famili cicadellida | D006430 | T204 |
34,677,606 | prevent amyotroph later sclerosi insight pre symptomat neurodegen diseas signific progress made understand pre symptomat phase amyotroph later sclerosi much still unknown advanc neurodegen diseas offer valuabl insight inde increas clear well recogn clinic syndrom alzheim diseas parkinson diseas huntington diseas spinal muscular atrophi frontotempor dementia also preced pre symptomat prodrom period vari durat under diseas process unfold associ compensatori chang loss inher system redund key insight diseas highlight opportun discoveri amyotroph later sclerosi develop biomark reflect amyloid tau led shift defin alzheim diseas base infer under histopatholog parkinson diseas uniqu among neurodegen diseas number divers non genet biomark pre symptomat diseas notabl rem sleep behaviour disord huntington diseas benefit abil predict like time clinic manifest diseas base age cag repeat length alongsid reliabl neuroimag marker atrophi spinal muscular atrophi clinic trial highlight transform valu earli therapeut intervent studi frontotempor dementia illustr differenti role biomark base genotyp similar advanc amyotroph later sclerosi would transform understand key event pathogenesi therebi dramat acceler progress toward diseas prevent deciph biolog pre symptomat amyotroph later sclerosi reli clear conceptu framework defin earliest stage diseas clinic manifest amyotroph later sclerosi may emerg abrupt especi among harbour genet mutat associ rapid progress amyotroph later sclerosi howev diseas may also evolv gradual reveal prodrom period mild motor impair preced phenoconvers clinic manifest diseas similar cognit behaviour impair present may emerg gradual evolv prodrom period mild cognit impair mild behaviour impair progress amyotroph later sclerosi biomark critic import studi pre symptomat amyotroph later sclerosi essenti effort interven therapeut clinic manifest diseas emerg use non genet biomark howev present challeng relat counsel inform consent communic result limit protect afford exist legisl experi pre symptomat genet test counsel legal protect discrimin base genet data may serv guid build learn broad pre symptomat neurodegen diseas specif amyotroph later sclerosi gene mutat carrier present road map earli intervent perhap even diseas prevent form amyotroph later sclerosi | D000544;D000690;D057180;D019636 | T048;T047 |
34,677,601 | marker immun activ inflamm individu postacut sequela sever acut respiratori syndrom coronavirus infect biolog process associ postacut sequela sever acut respiratori syndrom coronavirus sar cov infect pasc unknown | D000086382;D007249 | T046;T047;T067 |
34,677,595 | factor associ low valu cancer screen veteran health administr clinic practic guidelin recommend stop cancer screen risk exceed benefit yet low valu screen persist veteran health administr focus improv valu qualiti care use patient center medic home model may affect cancer screen behavior | D014493 | T092 |
34,677,593 | extend follow local steroid inject carpal tunnel syndrom random clinic trial local steroid inject common use treat patient idiopath carpal tunnel syndrom evid regard long term efficaci lack | D007267 | T169;T121 |
34,677,592 | assess percept mental health vs medic health plan network among us adult privat insur ten year mental health pariti addict equiti act patient continu report insur relat barrier specialti mental health care | D007722;D007348;D008603;D008605;D017149 | T057;T098;T041;T053;T058 |
34,677,591 | determin isol identif relat impur erdostein bulk drug erdostein mucolyt drug antioxid activ | D004340;D000431 | T121;T068;T109 |
34,677,589 | bodi mass index leptin relat cognit perform year women without hiv infect yet understood whether peopl live hiv infect increas risk alzheim diseas relat dementia due enhanc survivorship high effect antiretrovir therapi andor increas adipos age | D015992;D003071 | T041;T201 |
34,677,585 | phi thicken brassica oleracea root induc osmot stress mechan effect involv jasmon acid phi thicken peculiar secondari cell wall thicken found radial wall cortic cell plant root howev thicken widespread plant kingdom research develop lack describ simpl system rapid induct phi thicken primari root brassica four day old seedl transfer control agar plate new plate contain increas level osmotica phi thicken develop occur within narrow region differenti zone proport osmolar cellulos deposit lignif start h h respect howev osmoprotect fail induc phi thicken inhibit induct test combin thicken induc osmotica independ biomechan pathway exist regul phi thicken induct root growth rate substrat textur import factor determin thicken induct phi thicken develop also control stress relat plant hormon notabl jasmon acid also abscis acid research provid first understand development pathway control phi thicken induct also provid tool function enigmat structur might clarifi | D001937;D018517 | T002;T168 |
34,677,584 | delin infect strategi leishmania donovani secretori protein human host pathogen protein interactom predict interact leishmania donovani secretori virul factor host protein interplay infect process human poor studi viscer leishmaniasi lack holist studi pathway level de regul caus due virul factor lead poor understand parasit strategi subvert host immun respons secur surviv insid host spread infect viscer organ studi propos comput workflow predict host pathogen protein interactom ldonovani secretori virul factor human protein combin sequenc base interolog map structur base domain interact map techniqu employ graph theoret approach shortest path method analyz interactom studi deciph infect path involv uniqu understudi diseas associ signal pathway influenc cellular phenotyp respons host statist analysi base silico knockout studi unveil first time ubc z hsa mediat protein potenti immunomodulatori candid virul factor employ infect path identifi pathway novel mediat protein effect use possibl target control modul infect process aid treatment viscer leishmaniasi | D006790 | T070 |
34,677,583 | earli life formula feed associ infant gut microbiota alter increas antibiot resist load infant high risk acquir fatal infect treatment reli function antibiot antibiot resist gene arg present high number antibiot naiv infant gut microbiom infant mortal caus resist infect high role antibiot shape infant resistom studi limit knowledg factor affect antibiot resist burden infant gut | D007227 | T040;T061 |
34,677,582 | multifunct prostat acid phosphatas prostat cancer pathogenesi role human prostat acid phosphatas pacp pppaphuman prostat cancer investig use new proteom tool term signal sequenc swap replac domain nativ cleav amino termin signal sequenc secretorymembran protein correspond region function distinct signal sequenc subtyp manipul preferenti redirect protein differ pathway biogenesi endoplasm reticulum er magnifi normal difficult detect subset protein interest pacp techniqu reveal three form ident amino acid sequenc profound differ physiolog function subcellular locat biochem properti three form pacp also occur wildtyp pacp signal sequenc clinic specimen patient prostat cancer demonstr one form term plpacp correl earli prostat cancer find confirm analyt power method implic plpacp prostat cancer pathogenesi suggest novel anticanc therapeut strategi | D049109 | T043 |
34,677,581 | valid petrifilm coliform count plate enumer coliform bottl water aoac perform test methodsm petrifilm coliform count cc plate sampl readi cultur medium system contain modifi violet red bile nutrient cold water solubl gell agent tetrazolium indic facilit coloni enumer | D060766 | T167 |
34,677,578 | singl center surgeon long term year patient satisfact revis rate round textur eurosilicon breast implant breast augment one common perform aesthet plastic surgic procedur procedur unit state alon howev safeti breast implant close research monitor especi long term | D019928;D018427 | T074;T061 |
34,677,576 | valid environment scrub sampler wide spectrum neutral aoac perform test methodsm environment scrub sampler ml wide spectrum neutral nonspecif sampl devic intend use environment monitor surfac sampl | D005516;D008087 | T007;T067 |
34,677,575 | imagenet train deep neural network exhibit illus like respons scintil grid deep neural network dnn model comput vision capabl human level object recognit consequ similar dnn human vision interest character dnn represent scintil grid visual illus imag white disk perceiv partial black specif use vgg resnet dnn model train imag classif consid represent dissimilar l distanc penultim layer pair imag one white scintil grid disk disk decreas lumin level result show nonmonoton relat decreas disk lumin led increas subsequ decreas represent dissimilar scintil grid imag white disk closer term represent imag black disk imag gray disk control nonillus imag nonmonoton rare result suggest nonmonoton deep comput represent potenti test illus like respons geometri dnn model | D007088 | T033;T048;T041 |
34,677,574 | fixat eye movement passiv versus activ sustain fixat task human fixat eye movement small precis high speed accur tool need fulli reveal properti function role fixat imag land retina move differ level visual demand task subject current studi adapt optic scan laser ophthalmoscop aoslo use imag track present varieti fixat target maltes cross disk concentr circl vernier tumbl e letter healthi subject differ passiv static activ discrimin task natur eye motion land posit target retina track space time retin imag direct high spatial arcmin tempor hz resolut comput eye motion exact trajectori fixat target motion retina confirm compar passiv task activ task elicit partial inhibit microsaccad lead longer drift period compens larger correct saccad consequ overal fixat stabil activ task averag larger passiv task prefer retin locus fixat task coincid locat peak cone densiti | D005133;D005403 | T039;T042 |
34,677,568 | genom sequenc nie cyanobacteria collect focus heterocyst form clade cyanobacteria divers group gram negat prokaryot perform oxygen photosynthesi cyanobacteria use research photosynthesi attract attent platform biomaterialbiofuel product cyanobacteria also present almost habitat earth extens impact global ecosystem given biolog econom ecolog import number high qualiti genom sequenc cyanobacteria strain limit perform genom sequenc cyanobacteria strain nation institut environment studi microbi cultur collect japan sequenc strain form heterocyst morpholog distinct cell special fix nitrogen non heterocyst strain use illumina sequenc pair end mate pair librari silico finish construct high contigu assembl determin phylogenet relationship sequenc genom assembl found potenti difficulti classif certain heterocyst clade base morpholog observ also reveal bias sequenc strain phylogenet analysi rrna gene includ unsequenc strain genom sequenc cyanobacteria strain deposit worldwid cultur collect contribut understand enorm genet phenotyp divers within phylum cyanobacteria | D000458;D017753 | T070;T007;T082 |
34,677,565 | dual emiss supramolecular framework hydrogel bead high select detect antibiot mechan research ratiometr fluoresc probe base coordin polym cps wide appli optic applic therefor import develop dual emit gel materi base coordin polym specif recognit molecul cu atda h atda amino triazol diyl dibenzo acid synthes porous structur larg number amino site expos surfac regard carrier fluoresc molecul well dispers sa hydrogel network dual emiss eu function cp hydrogel bead acu atda eusa anthraldehyd sa sodium algin success prepar present ratiometr fluoresc detect flumequin low detect limit nm high select furthermor also display excel fluoresc quench effect nitrofuran antibiot exhibit dual function perform addit fluoresc respons mechan flumequin nitrofuran antibiot discuss depth portabl materi visual acu atda eusa bead provid extens conveni applic prospect real time monitor antibiot water environ | D005456 | T130 |
34,677,564 | synthesi carbon dot antiphag activ use caffeic acid recent studi preserv properti field materi scienc suggest newli synthes materi retain biolog properti raw materi still studi necessari sinc featur critic influenc research intersect materi scienc biolog could provid uniqu research direct synthesi new materi thus caffeic acid ca use raw materi synthes novel carbon quantum dot ca cds use simpl rapid hydrotherm method ca cds exhibit antiphag antibacteri activ use three type phage model confirm ca cds inhibit phage prolifer viral titr declin order magnitud ca cds display potenti univers antiphag abil mechan suggest ca cds could chang protein structur phage impact phage adsorpt stage lead loss infect meanwhil antibacteri activ retain ca cds signific inhibit growth gram posit bacteria also reveal preserv properti ca cds ca cds synthes ca expand rang antivir activ also increas mani uniqu optic properti carbon dot materi find meaning order promot develop new cds remark biolog activ act basi futur scientif research novel altern antivir treatment | D002244;D045663 | T121;T073;T196 |
34,677,483 | studi mechan blood glucos lower effect collagen peptid sturgeon product previous studi found collagen peptid prepar product bester sturgeon inhibitori effect elev blood glucos level glucos toler test icr mice present studi examin mechan effect sturgeon collagen peptid scps detail glucos oral administ mice along scps found glucos remain stomach longer time test amount glucos excret fece mice also increas contrari reveal scps dipeptidyl peptidas iv dpp iv inhibitori abil vitro test subsequ oral intraven glucos administr test glucagon like peptid glp insulin level blood mice maintain high level result suggest follow three mechan scps slow rate transport glucos stomach small intestin result delay glucos absorpt scps suppress absorpt glucos small intestin excret bodi scps inhibit dpp iv blood maintain high glp level blood turn stimul insulin secret | D005399 | T013 |
34,677,482 | synthesi bioactiv ancorinosid b marin diglycosyl tetram acid spong metabolit ancorinosid b prepar first time step yield featur galactopyranosyl glucuron acid tether aspart acid deriv tetram acid key step synthesi fulli protect lactos deriv thioglycosid attach c aldehyd spacer function latter termin n ketoacyl aspart basic dieckmann cyclize close pyrrolidin dion ring concomit global deprotect ancorinosid b exhibit multipl biolog effect medicin interest inhibit secret cancer metastasi relev matrix metalloproteinas mmp mmp also growth staphylococcus aureus biofilm ca appli concentr low gml concentr far mic ca gml thus unlik induc bacteri resist also led dispers preform aureus biofilm appli concentr ca gml ancorinosid b might thus interest candid control general hospit cathet joint prothes infect | D011161 | T204 |
34,677,481 | applic network approach assess chemic divers biogeographi pharmaceut potenti verongiida natur product studi provid review isol natur product nps report spong within order verongiida may includ comprehens compil geograph physico chemic paramet physico chemic paramet use studi infer pharmacokinet properti well potenti pharmaceut potenti nps order marin spong addit network analysi nps produc verongiida spong appli systemat explor chemic space relationship taxonomi secondari metabolit drug score variabl allow identif differ correl within dataset use scaffold network well bipartit relationship network provid platform explor chemic divers well use chemic similar network link pharmacokinet properti structur similar studi pave way futur applic network analysi procedur field natur product order famili | D000091484;D011161 | T204;T062;T170 |
34,677,479 | chemic constitu deep sea deriv penicillium solitum systemat chemic investig deep sea deriv fungus penicillium solitum mccc result isol one novel polyketid two new alkaloid known compound structur new compound establish main basi exhaust analysi nmr data viridicatol display moder anti tumor activ panc hela cell ic valu around moreov display potent vitro anti food allerg activ ic valu compar posit control loratadin indol acet acid methyl ester penicopeptid show moder effect ic respect | D010407 | T004 |
34,677,478 | posidonia oceanica l delil dampen cell migrat human neuroblastoma cell neuroblastoma nb common cancer childhood lethal high risk form primarili high metastat potenti target cancer cell migrat thus prevent metastasi format rational effect cancer therapi nb previous studi describ leaf extract posidonia oceanica marin plant poe antioxid anti inflammatori agent inhibitor cancer cell migrat studi aim examin poe anti migratori role human sh syy neuroblastoma cell under mechan action wound heal gelatin zymographi assay show poe earli time inhibit cell migrat reduc pro mmp releas cultur medium monitor express level key autophagi marker western blot assay correl poe induc cell migrat inhibit autophagi activ demonstr cell morpholog immunofluoresc analys show poe induc neurit format neuron differenti later time result suggest poe might act cell migrat trigger earli nontox autophagi poe induc cellular morpholog chang toward cell differenti might contribut prolong phytocomplex anti migratori effect later time overal result encourag futur vivo studi test poe applic neuroblastoma treatment | D035961 | T002 |
34,677,477 | nutrit valu biofunct two edibl green seawe ulva lactuca caulerpa racemosa indonesia subcrit water hydrolysi caulerpa racemosa sea grape ulva lactuca sea lettuc edibl green seawe good sourc bioactiv compound futur food nutraceut cosmeceut industri present studi determin nutrit valu investig recoveri bioactiv compound c racemosa u lactuca use hot water extract hwe subcrit water extract swe differ extract temperatur c besid signific higher extract yield swe process also give higher protein sugar total phenol tpc saponin tsc flavonoid content tfc antioxid activ compar convent hwe process swe process appli highest tpc tsc tfc valu obtain u lactuca hydrolyz reaction temperatur c valu gae mgg de mgg qe mgg respect addit also show highest antioxid activ valu ascorb acid equival aae mgg trolox equival te mgg abt total antioxid respect highest phenol acid u lactuca gallic acid vanil acid cytotox assay demonstr c racemosa u lactuca hydrolys obtain hwe swe show toxic effect raw cell test concentr h h treatment p suggest hydrolys safe non toxic applic food cosmeceut nutraceut product addit result studi demonstr potenti swe product high qualiti seawe hydrolys collect studi show potenti exploit tropic green seawe resourc potenti antioxid nutraceut cosmeceut product | D055951;D012624 | T204;T168 |
34,677,476 | vitro anti orthohantavirus activ high low molecular weight fraction fucoidan brown alga fucus evanescen hantaan orthohantavirus genovari amur amrv rodent born zoonot virus causat agent haemorrhag fever renal syndrom human current limit therapeut option requir develop effect anti orthohantavirus drug abil nativ fucoidan fucus evanescen fef enzymat prepar high molecular weight fehmp low molecular weight felmp fraction inhibit differ stage amrv infect vero cell studi structur deriv obtain determin use nuclear magnet reson nmr spectroscopi found fucoidan deriv exhibit signific antivir activ affect earli stage amrv lifecycl notabl virus attach penetr fehmp felmp fraction show highest anti adsorpt activ inhibit amrv focus format select index si fef si felmp fraction show greater virucid effect compar fef fehmp fraction shown molecular dock sulphat fucotetrasaccharid main compon felmp fraction abl bind amrv envelop glycoprotein gngc integrin prevent virus cell interact relat small size site interact explain higher anti amrv activ felmp fraction | D000459 | T204 |
34,677,475 | laminarin major polysaccharid stramenopil process primari secondari endosymbiosi differ microalga evolv synthesi differ storag polysaccharid stramenopil main storag polysaccharid glucan laminarin vacuol current laminarin gain consider attent due applic food cosmet pharmaceut industri also import global biogeochem cycl especi ocean carbon cycl review structur composit content bioactiv laminarin summar differ alga shown general featur laminarin speci depend furthermor propos biosynthesi catabol pathway laminarin function key gene diel regul laminarin also depict comprehens discuss first time howev complet pathway function gene diel regulatori mechan laminarin requir biomolecular studi review provid use inform identifi knowledg gap regard futur studi laminarin applic | D058009 | T204 |
34,677,473 | valor red alga gelidium sesquipedal extract broad spectrum minor compound use green approach red alga gelidium sesquipedal primarili exploit agar product leav undervalu biomass work use eco friend approach employ ultrasound assist extract uae green solvent investig valor algal minor compound green method use herein show attract altern effici extract broad spectrum bioactiv compound short extract time min vs h convent method use best uae condit red seawe extract character term total phenol mg gae g dw flavonoid mg qe g dw mycosporin like amino acid maa maa mg g dw phycobiliprotein mg g dw addit produc algal extract exhibit interest antioxid anti enzymat activ potenti applic medic andor cosmet product thus studi provid basi reach superior valor algal biomass use altern method extract biolog activ compound follow eco friend approach moreov strategi develop open new possibl commerci use gelidium sesquipedal also valor differ alga speci sinc techniqu establish easili adapt | D000461 | T002 |
34,677,472 | microalga sustain biofactori produc high valu lipid biodivers exploit biotechnolog applic microalga often call sustain biofactori due dual potenti mitig atmospher carbon dioxid produc great divers high valu compound nevertheless success exploit microalga biofactori industri scale depend choos right microalga optimum growth condit due rich biodivers microalga screen pipelin develop perform microalg strain select explor growth robust metabolit product current prospect microalg biotechnolog turn focus high valu lipid pharmaceut nutraceut cosmet product within microalg lipid fraction polyunsatur fatti acid carotenoid broad recogn vital function human organ microalg deriv phytosterol still underexploit lipid resourc despit present promis biolog activ includ neuroprotect anti inflammatori anti cancer neuromodulatori immunomodulatori apoptosi induct effect modul microalg biochem composit accord intend field applic import know contribut cultiv factor combin effect want product accumul microalga vital role play futur low carbon economi sinc microalg biodiesel still cost desir explor potenti oleagin speci high valu lipid present great global market prospect | D001688 | T121;T123 |
34,677,471 | research progress anti inflammatori bioactiv substanc deriv marin microorgan spong alga coral inflamm bodi defens reaction respons stimul basi various physiolog patholog process howev chronic inflamm undesir close relat occurr develop diseas ocean give birth uniqu divers bioactiv substanc gain special attent focus anti inflammatori drug develop far numer promis bioactiv substanc obtain various marin organ marin bacteria fungi spong alga coral review cover bioactiv substanc describ includ structur speci sourc evalu model anti inflammatori activ substanc review aim provid refer research progress marin organ deriv anti inflammatori metabolit give research impetus convers novel anti inflammatori drug | D059001;D001688 | T121;T001;T123 |
34,677,470 | thraustochytrid mangrov habitat andaman island speci divers pufa profil biotechnolog potenti thraustochytrid promis microbi sourc commerci product docosahexaeno acid dha applic human health aquacultur nutraceut sector present studi isol thraustochytrid strain mangrov habitat south andaman island india studi divers polyunsatur fatti acid pufa biotechnolog potenti predomin strain identifi belong two major genera thraustochytrium aurantiochytrium base morpholog molecular characterist strain anvkk produc maximum biomass gl anvkk exhibit maximum total lipid omega pufa eicosapentaeno acid epa accumul anvkk docosapentaeno acid dpa anvkk dha anvkk anvkk show maximum scaveng activ anvkk anvkk display highest antibacteri activ human fish pathogen aureus mm v parahaemolyticus mm respect strain non toxic evid negat blood agar hemolysi thus thraustochytrid suggest potenti sourc dha applic health care human fish | D053833 | T070;T083 |
34,677,469 | chondracanthus teedei var lusitanicus nutraceut potenti unexploit marin resourc present high demand nutrit enhanc food current challeng look new raw food sourc supplement benefici human diet nutrit profil key secondari metabolit red seawe rhodophyta gain interest challeng context possibl use red seawe chondracanthus teedei var lusitanicus gigartinal novel nutraceut sourc investig result highlight high miner content seawe repres g g dri weight dw despit low level calcium phosphorus g g dw respect seawe interest sourc nitrogen potassium g dw accord furthermor high content carbohydr g g dw act dietari fiber confer low calor content raw food sourc thus studi demonstr c teedei var lusitanicus fact unexploit potenti resourc capabl provid key miner human diet promis nutraceut properti | D019587;D012624 | T204;T168;T061 |
34,677,468 | chang trend paralyt shellfish poison reflect increas sea surfac temperatur practic indigen recreat harvest british columbia canada paralyt shellfish poison psp occur shellfish contamin saxitoxin equival paralyt shellfish toxin psts ingest british columbia canada document poison increas frequenc base investig identifi two psp investig report compar sinc p coincid rise global temperatur r p major psp investig case link self harvest shellfish far investig involv harvest indigen communiti commerci recreat group singl case exposur investig increas time decad compar previous period clam mussel oyster scallop recent year crab link ill guid understand self harvest consumpt risk recommend collect data determin pst produc alga present high concentr improv qualiti data onlin shellfish harvest map includ date last test biotoxin test result descript bivalv speci test relianc toxin result biomonitor speci may address actual consumpt risk unmonitor speci harvest area recommend introduc phytoplankton monitor remot indigen communiti self harvest common toxin test unavail well continu participatori educ biotoxin risk seafood | D012758 | T204 |
34,677,467 | cultur marin spong cell product bioactiv compound product spong deriv bioactiv compound vitro propos altern wild harvest aquacultur chemic synthesi meet demand clinic drug develop manufactur recent possibl marin invertebr cell line recent breakthrough develop spong cell line rapid cell divis improv nutrient media make approach viabl option hypothes three dimension cell cultur would better repres spong function natur includ product bioactiv compound success cultur spong cell matric use fibracel disk thin hydrogel layer gel microdroplet gmds vitro product bioactiv compound use gmds recommend nutrient spong product rapid diffus matrix gmds may scale spinner flask cell andor secret product easili recov research scale product progress laboratori | D017756;D011161 | T167;T204;T057 |
34,677,466 | identifi potenti antioxid properti viscera sea snail turbo cornutus turbo cornutus horn turban sea snail found along intertid basalt shorelin jeju island korea cornutus feed seawe eg undaria sp ecklonia sp compos divers antioxid studi identifi potenti antioxid properti cornutus viscera tissu divers extract evalu hydrogen peroxid h scaveng activ cornutus viscera protamex assist extract tvp purifi gel filtrat chromatographi gfc potenti antioxid properti analyz amino acid sequenc peroxidas inhibit effect silico molecular dock vitro analysi accord result cornutus viscera tissu compos mani protein content among extract tvp possess highest h scaveng activ addit tvp gfc signific decreas intracellular reactiv oxygen speci ros level increas cell viabil h treat hepg cell without cytotox tvp gfc compris nine low molecular bioactiv peptid elr vgpq tdi alpha pah vdi wsdk vfsp fapqi notabl peptid dock activ site myeloperoxidas mpo especi tdi fapqi show mpo inhibit effect ic valu respect altogeth find demonstr cornutus viscera potenti antioxid properti use high valu ad ingredi | D012908 | T204 |
34,677,464 | potenti protect effect possibl mechan peptid oyster crassostrea hongkongensi hydrolys triptolid induc testi injuri male mice peptid oyster hydrolys op varieti biolog activ howev protect effect exact mechan testicular injuri remain poor understood studi aim evalu protect effect op triptolid tp induc testi damag spermatogenesi dysfunct investig under mechan work tp induc testi injuri model creat op gavag mice week result show op signific improv sperm count motil mice allevi seminifer tubul injuri studi show op decreas malonaldehyd mda level increas antioxid enzym sod gph px activ attenu oxid stress therebi reduc number apoptot cell testi addit op improv activ enzym ldh alp acp relat energi metabol testi restor serum hormon level mice normal furthermor op promot express nrf protein increas express antioxid enzym regulatori protein ho nqo testi op inhibit jnk phosphoryl bcl bax mediat apoptosi conclus op protect effect testicular injuri spermatogenesi disord caus tp suggest potenti protect op male reproduct | D049896 | T204 |
34,677,462 | potenti biomed applic collagen filament deriv marin demospong ircinia oro schmidt sarcotragus foetidus schmidt collagen filament deriv two marin demospong ircinia oro sarcotragus foetidus first time isol biochem characteris test potenti use regen medicin sds page isol filament reveal main collagen subunit band kda sampl studi dsc analysi membran produc collagen spong filament show higher thermal stabil commerci mammalian deriv collagen membran dynam mechan thermal analysi attest membran obtain filament foetidus resist stabl rise temperatur compar one deriv filament oro moreov former higher stabil salin collagenas solut evid antioxid activ convers water bind capac result lower membran obtain oro adhes prolifer test use l fibroblast hacat keratinocyt result remark biocompat develop membran model gene express analysi show evid regul ecm relat gene final membran oro signific increas type collagen gene express releas cultur medium find report strong suggest biotechnolog potenti collagen structur poriferan origin scaffold wound heal | D011161 | T204 |
34,677,461 | voltag gate sodium channel promin target marin toxin voltag gate sodium channel vgscs consid one import ion channel given remark physiolog role vgscs constitut famili larg transmembran protein allow transmiss generat propag action potenti occur conduct na ion membran support cell excit communic signal various system result wide rang coordin physiolog function locomot cognit accomplish drug target alter molecular mechan vgscs function high contribut discoveri percept function structur channel among drug various marin toxin produc harm microorgan venom anim toxin play key role understand mode action vgscs map various alloster bind site furthermor marin toxin appear emerg sourc therapeut tool reliev pain treat vgsc relat human channelopathi sever studi document effect marin toxin vgscs well pharmaceut applic none underlin princip marin toxin effect vgscs therefor review aim highlight neurotoxin produc marin anim pufferfish shellfish sea anemon cone snail activ vgscs discuss pharmaceut valu | D001688 | T121;T123 |
34,677,460 | scalaran type sesterterpenoid marin spong lendenfeldia sp allevi inflamm human neutrophil spong deriv scalaran remark sesterterpenoid previous found exhibit profound inhibitori effect neutrophil inflamm current work construct metabolom profil marin spong lendenfeldia sp first time use tandem mass spectrometri msms molecular network approach result highlight rich chemic divers scalaran motiv us conduct research discov novel scalaran target neutrophil inflamm ms nmr assist isol elucid led discoveri seven new homoscalaran lendenfeldaran k q character methyl c togeth five known deriv lendenfeldaran b methyl dioxoscalar en oic acid methyl trioxoscalar en oic acid felixin b hydroxi methyldeoxoscalarin scalaran assay superoxid anion generat elastas releas repres neutrophil inflammatori respons respiratori burst degranul respect result indic exhibit potenti anti inflammatori activ ic superoxid anion scaveng ic elastas releas | D011161 | T204 |
34,677,459 | antioxid bioactiv extract beach cast leav posidonia oceanica l delil marin environ generous sourc biolog activ compound use human health year bioactiv marin compound identifi increas per year peculiar featur alga plant product secondari metabolit polyphenol synthes form adapt environment stress posidonia oceanica mediterranean endem domin seagrass repres biolog ecolog geolog import marin ecosystem within studi methanol ethanol extract generat fresh dri posidonia nbsp oceanica leav aim employ valor beach cast leav best yield antioxid activ polyphenol content equal mg gaeg dpph ic gl record ethanol extract gd e obtain leav dri two day c ground four time hplc analys reveal presenc polyphenol compound abund chicor acid antioxid benefici properti bioactiv properti gd e extract evalu vitro use fibroblast cell line hs subject uv induc oxid stress pre treatment cell gd e extract led signific protect oxid stress mortal associ uv exposur thus highlight benefici properti antioxid compound produc marin plant photo damag free radic associ negat cellular effect beach cast leav select process extract procedur vitro assay result suggest potenti sustain approach biotechnolog exploit resourc could serv model marin resourc | D035961 | T002 |
34,677,458 | exogen antioxid improv accumul satur polyunsatur fatti acid schizochytrium sp pku mn speci schizochytrium well known remark abil produc lipid intracellular howev lipid accumul reactiv oxygen speci ros generat inevit byproduct excess result lipid peroxid allevi ros induc damag seven differ natur antioxid ascorb acid tocopherol tea extract melatonin mannitol sesamol butyl hydroxytoluen evalu effect lipid accumul schizochytrium sp pku mn use fraction factori design among test antioxid mannitol show best increment total fatti acid concentr howev interact effect mannitol gl ascorb acid gl result gl gl satur polyunsatur fatti acid sfa pufa respect batch ferment concentr increas gl sfa gl pufa fed batch ferment notabl interact effect yield increment sfa pufa concentr batch ferment possibl mechan underlin increment increas maximum growth rate strain pku mn allevi ros level differenti express lipid biosynthet gene andupregul catalas gene studi provid applic strategi improv accumul sfa pufa thraustochytrid exogen antioxid under mechan | D059001 | T001 |
34,677,457 | recent updat marin cancer prevent compound natur compound deriv marin organ often exhibit uniqu chemic structur potent biolog activ cancer prevent activ one rather new activ emerg extens studi last decad review summar recent updat marin chemoprevent compound cover relev literatur publish follow previous comprehens review stonik fedorov marin drug current articl molecul effect malign transform relat pathway molecul cancer stem cell carcinogen induc vivo tumor develop consid true cancer prevent compound therefor review addit particular attent given molecular mechan chemoprevent execut report marin compound | D000970;D059001;D001688;D018890 | T121;T109;T123;T001;T061 |
34,677,456 | evalu effect fucoidan fucus speci laminaria hyperborea oxid stress iron depend cell death fucoidan algal polysaccharid exhibit protect properti oxid stress aim studi investig differ fucoidan brown seawe abil protect iron depend oxid stress ferroptosi main hallmark retin brain diseas includ hemorrhag investig five new high molecular weight fucoidan extract fucus vesiculosus f serratus f distichus subsp evanescen previous publish laminaria hyperborean extract commerci avail extract f vesiculosus undaria pinnatifida induc oxid stress glutathion deplet erastin h four retin neuron cell line well primari cortic neuron extract f serratus f distichus subsp evanescen laminaria hyperborea partial protect erastin induc cell death arp omm cell none extract show benefici effect neuron cell protect fucoidan also attenu decreas protein level antioxid enzym gpx key regul ferroptosi comprehens analysi demonstr antioxid abil fucoidan may cell type specif besid depend algal speci extract method futur studi need character health benefit effect fucoidan determin exact mechan under antioxid abil | D044645;D007795 | T204;T121;T002 |
34,677,453 | chemic structur anticoagul properti novel sulfat polysaccharid green alga cladophora oligoclada marin macroalga effici produc sulfat polysaccharid algal sulfat polysaccharid possess divers bioactiv peculiar chemic structur repres great potenti sourc explor present studi heparinoid activ sulfat polysaccharid isol green alga cladophora oligoclada result chemic spectroscop analys indic sulfat polysaccharid compos gal p gal p glc p gal p unit sulfat ester c c gal p c gal p c glc p unit branch consist gal p gal p unit locat c gal p unit sulfat polysaccharid exhibit potent anticoagul activ vitro vivo evalu activ partial thromboplastin time aptt thrombin time fibrinogen level aptt signal clot time gml vitro mgkg vivo obvious thrombolyt activ sulfat polysaccharid vitro also found mechan analysi anticoagul action demonstr sulfat polysaccharid signific inhibit activ intrins coagul factor less gml select inhibit common coagul factor furthermor sulfat polysaccharid strong stimul inhibit thrombin potenti antithrombin iii iii heparin cofactor ii also larg promot inhibit factor xa mediat iii result reveal sulfat polysaccharid c oligoclada potenti becom anticoagul agent prevent therapi thrombot diseas | D000460 | T002 |
34,677,452 | marin fungal cerebrosid flavusid b protect hacat keratinocyt staphylococcus aureus induc damag cerebrosid glycosyl sphingolipid mammal contribut pro anti inflammatori properti innat antimicrobi activ skin mucos surfac staphylococcus aureus infect develop minor scratch skin pathogen also activ promot epitheli breach effect cerebrosid flavusid b marin sediment deriv fungus penicillium islandicum aniva bay sea okhotsk viabil apoptosi total caspas activ cell cycl human epiderm keratinocyt hacat line co cultiv aureus well influenc flavusid b lps treat hacat cell studi influenc flavusid b bacteri growth biofilm format aureus effect enzymat activ sortas also investig found aureus co cultiv keratinocyt induc caspas depend apoptosi cell death arrest cell cycl gg phase increas cellular immun inflamm cerebrosid flavusid b demonstr antimicrobi anti inflammatori properti substanti elimin negat consequ caus co cultiv keratinocyt aureus bacteri lps dual action flavusid b may high effect treatment bacteri skin lesion studi futur vivo experi | D010407 | T004 |
34,677,451 | appli seawe compound cosmet cosmeceut nutricosmet interest seawe cosmet cosmeceut nutricosmet increas base demand natur ingredi seawe offer advantag relat renew charact wide distribut rich versatil valuabl bioactiv compound use ingredi addit activ agent formul skin care product bioactiv compound polyphenol polysaccharid protein peptid amino acid lipid vitamin miner respons biolog properti associ seawe seawe fraction also offer technic featur thicken gell emulsifi textur moisten develop cohes matric furthermor possibl valor industri wast stream algal bloom make attract low cost raw renew materi review present updat summari activ differ seawe compound fraction base scientif patent literatur | D012624 | T204 |
34,677,450 | chitosan base scaffold miner tissu regener convent bone graft procedur use treat bone defect sever limit import aspect bone tissu engin develop novel bone substitut biomateri bone graft repair orthoped defect consider attent given chitosan natur biopolym primarili extract crustacean shell offer desir characterist biocompat biodegrad osteoconduct review present overview chitosan base biomateri bone tissu engin bte cover basic knowledg chitosan term biomateri tradit novel strategi chitosan scaffold fabric process advantag disadvantag furthermor paper integr relev contribut give brief insight recent research develop chitosan base scaffold limit bte last part review discuss next generat smart chitosan base scaffold current applic regen dentistri futur direct field miner tissu regener | D016025;D048271;D054457 | T121;T122;T061;T109 |
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