PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,678,162 | dispar insult relev schizophrenia converg impair spike synchroni weaker synapt interact prefront local circuit schizophrenia result hundr known caus includ genet environment development insult cooper increas risk develop diseas spite divers causal factor schizophrenia present core set symptom brain abnorm structur function particular impact prefront cortex suggest mani differ causal factor lead schizophrenia may caus prefront neuron circuit fail fundament similar way natur converg malfunct prefront circuit cell synapt level lead schizophrenia known appli converg guid search identifi core patholog chang function properti prefront circuit lie downstream mechanist distinct insult relev diseas compar impact block nmda receptor monkey delet schizophrenia risk gene mice activ time effect communic prefront local circuit although manipul oper distinct molecular pathway biolog mechan found produc converg pathophysiolog effect prefront local circuit manipul reduc frequenc synchron lag spike prefront neuron weaken function interact prefront neuron monosynapt lag measur inform transfer neuron two observ may relat reduct synchron spike prefront neuron would expect weaken synapt connect via spike time depend synapt plastic data suggest link spike time synapt connect could compris function vulner multipl risk factor exploit produc diseas | D012559 | T048 |
34,678,161 | leverag health system data character larg effect variant confer risk liver diseas puerto rican integr genom data health system offer opportun identifi genom factor under continuum rare common diseas appli popul scale haplotyp associ approach base ident descent ibd larg multi ethnic biobank spectrum diseas outcom deriv electron health record ehr uncov risk locus liver diseas use genom sequenc silico approach fine map signal non code variant c c gene abcb vitro analysi confirm variant disrupt splice abcb pre mrna four five homozygot evid advanc liver diseas signific associ liver diseas among heterozygot suggest variant link increas risk liver diseas allel dose depend manner popul level screen reveal variant carrier rate puerto rican individu like result puerto rican founder effect work demonstr integr ehr genom data popul scale facilit strategi understand continuum genom risk common diseas particular popul underrepres genom medicin | D020022 | T032 |
34,678,160 | screen compound librari h mediat cancer therapeut use peroxiredoxin base sensor compound modul h reaction network applic target cancer therapeut subset cancer exhibit sensit redox signal previous studi identifi therapeut induc oxid reli upon probe respond mani differ oxid cell thus report h redox signal select oxid protein use genet encod fluoresc probe human peroxiredoxin prx oxid screen small molecul compound modul h pathway character cellular respons sever compound select screen result reveal compound enact h mediat toxic cell among smer antifung report oxid induc drug sever drug includ cisplatin previous shown induc reactiv oxygen speci ros appear oxid prx suggest h among ros induc drug | D009369;D054464 | T191;T121;T126;T116 |
34,678,156 | prospect prostat cancer screen programm men pathogen variant mismatch repair gene impact initi result intern prospect studi lynch syndrom rare famili cancer syndrom caus pathogen variant mismatch repair gene mlh msh msh pms caus predisposit various cancer predomin colorect endometri cancer data emerg pathogen variant mismatch repair gene increas risk earli onset aggress prostat cancer impact studi prospect assess prostat specif antigen psa screen men germlin mismatch repair pathogen variant report use psa screen prostat cancer incid tumour characterist first screen round men without germlin pathogen variant | D055088 | T058;T060 |
34,678,155 | particul matter promot melanin product endoplasm reticulum stressmedi ire signal particul matter pm believ relat cardiovascular respiratori diseas skin also known affect pm exposur result skin barrier dysfunct cutan inflamm apoptot cell death epidemiolog studi suggest pm relat pigment spot recent diesel exhaust particl report caus tan respons mediat oxid stress howev direct effect pm melanogenesi relat mechan yet clarifi studi show pm increas melanin product melanocyt mous skin human skin model rna sequenc analys melanocyt reveal express unfold protein respons molecul increas pm exposur particular ire signal pathway consist upregul relat pm trigger melanogenesi addit pm induc melanogenesi abrog ire inhibitor therefor find corrobor previous find melanocyt mous human model also illumin involv ire pathway mechan pm induc melanogenesi | D008543;D052638 | T167;T131;T109;T123 |
34,678,149 | seqe find hidden medulloblastoma cell minim residu diseas mrd assess revolution clinic manag pediatr leukemia remain challeng implement pediatr brain tumor issu cancer cell liu et al describ approach measur mrd pediatr medulloblastoma use cell free dna cerebrospin fluid import prognost implic | D002528;D008527 | T191 |
34,678,148 | learn prospect retrospect cognit map within neural circuit brain circuit thought form cognit map process store statist relationship environ cognit map common defin mental represent describ environment state ie variabl event relationship state process common conceptu prospect process base relationship state chronolog order eg reward follow given state perspect expand concept basi recent find postul addit prospect map brain form use retrospect cognit map eg given state preced reward demonstr mani neural signal behavior eg habit seem inflex non cognit result retrospect cognit map togeth present signific conceptu refram neurobiolog studi associ learn memori decis make | D007858;D012201 | T061;T062;T041 |
34,678,147 | compartment dynam within common multi area mesoscal manifold repres repertoir human hand movement human hand uniqu anim kingdom unparallel dexter rang complex prehens fine finger individu brain repres divers repertoir movement evalu mesoscal neural dynam across human grasp network use electrocorticographi dimension reduct method repertoir hand movement strike found grasp network repres finger grasp movement alik specif manifold character multi areal neural covari structur preserv movement across distribut network contrast latent neural dynam within manifold surpris specif movement type align latent activ kinemat uncov distinct submanifold despit similar synergist coupl joint movement thus find despit preserv neural covari distribut network level mesoscal dynam compartment movement specif submanifold mesoscal organ may allow flexibl switch repertoir hand movement | D006225;D009068 | T040;T023 |
34,678,146 | rapid synapt plastic contribut learn conjunct code posit choic relat inform hippocampus success perform goal direct navig anim must know eg look water bring food back nest escap predat hippocamp neuron code critic variabl conjunct littl known wherewhat code form flexibl rout brain region address question perform intracellular whole cell record mous ca cu two choic virtual navig task demonstr plateau potenti ca pyramid neuron rapid strengthen synapt input carri conjunct inform posit choic plastic induc respons field modul cue anim previous train collect reward base avail cue thus reveal gradual learn requir format conjunct popul code upstream ca plateau potenti induc synapt plastic ca enabl flexibl rout code downstream brain region | D056547;D009473 | T042;T023;T029;T043 |
34,678,141 | undibacterium baiyunens sp nov undibacterium curvum sp nov undibacterium fentianens sp nov undibacterium flavidum sp nov undibacterium griseum sp nov undibacterium hunanens sp nov undibacterium luofuens sp nov undibacterium nitidum sp nov undibacterium rivi sp nov undibacterium rugosum sp nov undibacterium umbellatum sp nov isol stream china twelv gram stain negat catalas oxidas posit rod shape motil strain cyw cyw cyw ftw ftw ftw bysw bysw lfsw lxw lxw nlw isol stream china comparison base rrna gene sequenc indic strain take speci genus undibacterium close neighbour reconstruct phylogenet phylogenom tree also show strain cluster speci genus undibacterium togeth genom gc content strain rang mol calcul pairwis orthoaniu valu digit dna dna hybrid valu among strain relat strain rang except valu strain cyw bysw respect q predomin respiratori quinon c c c major fatti acid polar lipid profil similar includ phosphatidylglycerol phosphatidylethanolamin one unidentifi phospholipid two kind unidentifi aminolipid combin polyphas taxonom characterist phylogenet relationship twelv strain repres eleven independ novel speci genus undibacterium name undibacterium baiyunens sp nov type strain bysw gdmcc kctc undibacterium curvum sp nov type strain cyw gdmcc kacc undibacterium fentianens sp nov type strain ftw gdmcc kctc undibacterium flavidum sp nov type strain lxw gdmcc jcm undibacterium griseum sp nov type strain ftw gdmcc kacc undibacterium hunanens sp nov type strain cyw gdmcc kacc undibacterium luofuens sp nov type strain lfsw gdmcc kctc undibacterium nitidum sp nov type strain lxw gdmcc kacc undibacterium rivi sp nov type strain ftw gdmcc kctc undibacterium rugosum sp nov type strain cyw gdmcc kacc undibacterium umbellatum sp nov type strain nlw gdmcc kacc propos | D010802;D045483 | T070;T062;T078 |
34,678,140 | collimona silvisoli sp nov collimona humicola sp nov two novel speci isol forest soil three aerob gram stain negat non motil rod shape bacteria design strain rxd rxd rltw isol two forest soil sampl nanl nation natur reserv guangdong provinc pr china phylogenet analys base rrna gene sequenc core gene show belong genus collimona close relat four valid publish speci similar rang genom dna gc content strain rxd rxd rltw mol respect genom deriv averag nucleotid ident ani digit dna dna hybrid dddh valu novel strain close relat type speci respect meanwhil ani dddh valu strain rxd rltw respect three novel strain contain c c cyclo sum featur c c andor c c major fatti acid sum featur c c andor c c compris relat higher proport strain rxd strain strain rxd rltw phosphatidylglycerol pg phosphatidylethanolamin pe diphosphatidylglycerol dpg unidentifi aminophospholipid apl main polar lipid pe apl detect strain rxd ubiquinon predomin quinon base phenotyp chemotaxonom phylogenet genom analys strain rxd consid repres one novel speci within genus collimona strain rxd rltw anoth one name collimona silvisoli sp nov collimona humicola sp nov propos rxd gdmcc kacc rltw gdmcc kacc type strain respect | D005227;D010802;D012988 | T109;T123;T168;T067;T078;T062 |
34,678,137 | implement share decis make lung cancer screen across veteran health administr hospit network hybrid effect implement studi protocol share decis make sdm lung cancer screen lcs recommend multipl organ reflect larger movement toward patient center care yet sdm lcs routin occur owe barrier multipl level moreov best implement sdm routin clinic practic remain unknown need novel approach overcom multilevel barrier ensur high qualiti sdm lcs integr routin practic present protocol us depart veteran affair va fund studi protocol design implement evalu multilevel tailor approach sdm lcs routin clinic practic within va new england health care network compris eight medic center prospect pragmat hybrid implement effect studi first conduct format evalu barrier sdm lcs level socioecolog model inform tailor implement plan sequenti introduc compon tailor multilevel approach implement sdm lcs across va new england final use mix method evalu implement impact effect primari outcom defin patient centered sdm well implement outcom inform aim implement scienc framework ie reach patient adopt provid implement fidel tailor implement address identifi challeng achiev polici recommend sdm lcs va new england inform nationwid implement sdm lcs address stakehold interest promot patient center interact across va | D055088;D008175 | T058;T191;T060 |
34,678,135 | indirect effect dissoci relationship lifetim ptsd symptom condomless sex among men sex men histori childhood sexual abus posttraumat stress disord ptsd symptom may interfer gay bisexu men sex men msm abil engag safe sex practic indirect relationship dissoci may help elucid relationship ptsd symptom sever condomless sex among msm childhood sexual abus csa histori relationship previous examin group uniqu vulner hiv acquisit cross section sampl msm histori csa n recruit studi site boston miami fl particip mean age year sd african american identifi latino sampl report mean sd lifetim ptsd symptom met clinic threshold dissoci logist regress model adjust age educ substanc use disord use assess indirect effect dissoci relationship lifetim ptsd symptom condomless analvagin sex episod serodiscord unknown status partner past month dissoci account associ lifetim ptsd symptom sever condomless sex episod sobel test sobel p ci bias correct bootstrap suggest signific indirect effect dissoci dissoci among msm csa histori may compromis accur apprais sexual risk safeti increas vulner hiv acquisit research warrant address hiv prevent context ptsd symptom sever improv mental health msm increas effect hiv prevent intervent | D002650;D015658;D000072339;D013313 | T048;T047;T098 |
34,678,133 | assess passeng long term vibrat discomfort field studi high speed train environ studi reveal mechan long term passeng vibrat discomfort high speed train propos novel evalu model assess popular intern standard iso unsuit field test conduct investig long term passeng vibrat comfort high speed train differ oper environ measur whole bodi vibrat wbv subject rate passeng comfort whole sit period high speed train passeng phenomena compensatori degrad discomfort accumul found meant brief termin vibrat fundament allevi passeng vibrat comfort vibrat comfort evalu product exposur time novel vibrat acceler index propos meanwhil high speed train higher veloc run tunnel environ higher frequenc weight wbv amplitud open air lower veloc caus vibrat discomfort passeng practition summari field studi provid data support ensur occup health train driver whose work rout involv larg number tunnel improv passeng vibrat comfort meanwhil novel idea provid evalu vibrat comfort passeng prolong exposur low amplitud environ | D016272;D014732 | T091;T070;T078 |
34,678,132 | novel cln mutat turkish patient variant late onset neuron ceroid lipofuscinosi recurr fractur caus sever morbid neuron ceroid lipofuscinosi ncl character ataxia epilepsi mental motor deterior visual loss phenotyp patient high heterogen report patient late infantil onset psychomotor retard visual loss seizur movement disord recurr bone fractur clinic exom sequenc reveal novel homozyg cdel pyf mutat cln variant detect associ simpl bone cyst ncl diseas difficult diseas recurr fractur signific increas morbid case report contribut genotyp spectrum cln emphas clinic import turkish patient cln mutat non ncl factorsdiseas advers affect morbid | D009472 | T047 |
34,678,131 | mycoplasma ovipneumonia induc caspas depend extrins apoptosi p ros depend intrins apoptosi murin alveolar macrophag mycoplasma ovipneumonia mo principl causat agent chronic respiratori diseas rumin includ sheep goat deer pose great threat rumin industri worldwid howev pathogenesi mo infect still remain well understood need clarif report time depend apoptosi cultur murin alveolar macrophag mh cell line respons mo infect vitro mechanist mo infect activ apoptosi mh cell caspas depend extrins pathway tumor protein p reactiv oxygen speci ros depend intrins mitochondri pathway moreov mo infect promot transcript translat proinflammatori cytokin gene includ interleukin il il tumor necrosi factor tnf caspas p ros depend manner impli potenti link mo induc inflamm apoptot cell death collect result suggest mo infect induc activ extrins intrins apoptot pathway cultur mh cell relat upregul express proinflammatori cytokin find contribut elucid pathogenesi mo infect provid valuabl refer develop new strategi control mo infect | D003670;D045802;D011019 | T047;T015;T007 |
34,678,130 | gut microbiota deriv bioactiv metabolit function host physiolog everi individu harbour complex divers mutualist microbi flora intestin time becam integr part bodi affect plethora activ host interact host gut microbiota affect sever aspect host physiolog gut microbiota affect host metabol ferment unabsorbedundigest carbohydr larg intestin metabol function disturb composit gut microbiota first year life may impact brain develop later affect cognit behaviour thus gut dysbiosi caus certain serious patholog condit host includ metabol disord inflammatori bowel diseas mood alter etc microbi metabolit recent time emerg key mediat respons microbiota induc benefici effect host review provid overview mechan microbi metabolit product respect physiolog function impact gut microbiom health diseas metabolit dietari fibr aromat amino acid tryptophan primari bile acid other potenti substanc link microbiota host physiolog mani metabolit act signal molecul number cell type also help secret hormon moreov interact microbiota deriv metabolit host immun boost mechan protect pathogen modul metabol also highlight understand function attribut metabolit produc gut microbiota may lead open new avenu prevent develop potent therapi sever diseas | D000069196;D015212;D064307 | T007;T047;T001;T032;T028 |
34,678,129 | interact e learn modul promot bio psycho social manag low back pain healthcar profession pilot studi low back pain lbp rank first musculoskelet disord consid year live disabl worldwid despit numer guidelin promot bio psycho social bps approach manag patient lbp mani health care profession hcps still manag lbp patient main biomed point view | D003194;D017116 | T065;T047;T184 |
34,678,128 | phase exploratori random control trial inopuls patient fibrot interstiti lung diseas requir oxygen rational patient fibrot interstiti lung diseas often progress point requir supplement oxygen invari accompani impair qualiti life limit activ daili live object studi aim assess improv physic activ patient interstiti lung diseas requir supplement oxygen treat puls inhal nitric oxid via inopuls bellerophon therapeut addit sought explor safeti clinic benefit inopuls multipl patient report outcom method ambulatori patient fibrot lung diseas supplement oxygen random ratio inhal nitric oxid gkg ideal bodi weighth ino placebo month month baselin blind treatment studi assess multipl exploratori efficaci endpoint includ moder vigor physic activ measur actigraphi patient report outcom use univers california san diego short breath questionnair st georg respiratori questionnair sgrq result total patient ino placebo enrol placebo correct clinic benefit mind increas mvpa observ ino group clinic meaning benefici trend observ univers california san diego short breath questionnair point sgrq total score well sgrq activ sgrq impact domain conclus inopuls well toler associ mainten physic activ improv symptomatolog patient interstiti lung diseas requir supplement oxygen valid benefici effect warrant studi phase trial current underway | D017563;D010100 | T047;T121;T196;T123 |
34,678,127 | glufosin ammonium herbicid potenti induc hormesi effect upland rice studi aim evalu effect low dose herbicid glufosin ammonium differ applic mode veget develop upland rice treatment consist combin five low dose g ai ha herbicid glufosin ammonium four applic mode low dose singl activ tiller floral differenti fd singl fd split two first begin second fd split three first begin second fd third fd hormesi effect rice crop due low dose glufosin ammonium veget develop rice plant reduc applic low dose applic mode lower plant height dri weight number panicl effect tiller | D000613;D006540;D059165;D012275 | T116;T121;T002;T109;T168;T131;T040 |
34,678,123 | mix method case studi explor primari care antibiot prescrib practic matern expect use antibiot children overus antibiot inappropri prescrib result rapid develop antimicrobi resist antibiot unit kingdom prescrib primari care general practition half prescrib viral rather bacteri ill | D058005;D012141 | T097;T047 |
34,678,121 | femor antegrad start tool fast intramedullari nail intramedullari im nail standard care adult lower extrem long bone fractur stabilis key procedur obtain correct entri point trajectori initi guid pin insert work present femor antegrad start tool fast surgic tool address lack connect utilis sequenti fluoroscop imag achiev align femor guid pin placement user centr design develop fast introduc perform devic evalu guid pin insert femor im nail seri sawbon cadaver model lead first human clinic cohort studi result demonstr potenti fast improv time consist guid pin insert femor im nail less experienc surgeon traine overal fast found easi use high degre clinic interest particular use larg patient accept motiv continu develop new technolog | D005264;D005594 | T061;T037 |
34,678,120 | explor pathway inflamm coagulopathi covid narrat tour viral rabbit hole worldwid covid pandem taken huge toll morbid mortal select patient classifi sever overwhelm inflammatori state impos infect accompani hypercoagul state hallmark uniqu pattern mark increas dimer proport marker coagulopathi review turn spotlight phenomenon offer unifi conceptu model depict lead hypothes coagulopathi covid key player coagul cascad accompani covid inflamm malfunct virtual everi level tissu factor express amplifi physiolog anti coagul pathway anti thrombin protein c inhibitor tissu factor pathway impair fibrinolysi inhibit compon autoimmun complement system amongst other contribut patholog data continu gather model offer pathophysiolog overview covid coagulopathi defin result histopatholog either intra vascular extra vascular hope review facilit understand serv lead point futur therapeut direct | D000086382 | T047;T067 |
34,678,118 | similar outcom new antevert straight standard stem random studi total hip arthroplasti evalu clinic variabl radiostereometri dxa year background purpos anatom uncement stem sp cl static physiologicus cementless design facilit insert avoid stress concentr solitari contact point market sinc well document studi clinic perform migrat associ bone remodel random control trial corail stem control patient method patient hip primarili recruit patient hip sp cl corail attend last follow year oxford hip score oh primari outcom addit assess stem migrat chang bone miner densiti develop radioluc rsa dxa convent radiographi result year oxford hip score similar sp cl corail stem year sp cl stem show median distal migrat mm corail stem mm sp cl stem show slight loss bone miner densiti gruen region p interpret found differ clinic result sp cl well document corail stem stem stabil reach year postop stem next step think sp cl stem studi multi center set accept general use | D005548;D006622;D011474 | T058;T074;T042 |
34,678,115 | effect risk percept access cannabi use among young popul spain find nation survey estud background cannabi use young popul undergon signific increas europ empir assess individu contextu mediat variabl relat cannabi use inform prevent action yet conduct spain object studi use nation survey drug use secondari educ spain estud inform potenti relev cannabi prevent target examin individu variabl sex age cannabi risk percept past day legal illicit substanc use substanc free activ contextu factor perceiv access cannabi associ past day cannabi use method data drawn adolesc femal structur equat model sem implement identifi predictor cannabi use indirect path test via bootstrap examin mediat effect cannabi risk percept access result demograph male sex higher age past day tobacco alcohol illicit substanc use associ past day cannabi use frequenc past year engag hobbi read also predict past day cannabi use mediat work relationship examin except hobbi illeg substanc use case access read hobbi case risk percept conclusionsimport cannabi use like emerg event low risk percept high access lower frequenc past year read higher engag hobbi often carri alon repres risk factor could potenti influenc prevent program | D002188;D019966 | T121;T002;T109;T167;T048;T033 |
34,678,114 | betel quid depend effect work memori remot memori chewer concurr use cigarett alcohol current studi ask whether bq depend level could affect work memori wm remot memori chewer concurr use cigarett alcohol common phenomenon taiwan | D000437;D062789 | T131;T048;T073;T109 |
34,678,113 | drink fit effect drink motiv self esteem alcohol use among femal colleg student past two decad rate alcohol use among femal student risen meet even surpass seen among male yet littl known factor play role relationship drink motiv alcohol consumpt femal colleg student present studi examin self esteem moder associ categori drink motiv alcohol use sampl femal colleg student | D000067292 | T054 |
34,678,110 | method statist analys studi motiv e cigarett use among univers student integr review understand motiv e cigarett use among colleg univers student essenti develop implement effect intervent evalu exist literatur necessari identifi methodolog gap limit improv qualiti futur research | D066300;D009042 | T080;T041;T073;T078 |
34,678,109 | fetal microchimer cell influenc experiment autoimmun myocard object investig presenc influenc fetal microchimer cardiac tissu mate femal mice submit experiment autoimmun myocard materi method nullipar balbc femal balbc femal mate either balbc male syngen mate cbl male allogen mate immun cardiac myosin peptid myhc kept non immun control immun occur week deliveri mice assess day result immun mice allogen mate lower product anti myhc antibodi compar immun nullipar mice immun nullipar femal intens mononuclear inflammatori infiltr cardiac tissu associ fibroplasia mate femal lower inflammatori reaction increas frequenc microchimer fetal cell observ mice submit allogen mate follow immun conclus allogen cell fetal origin could contribut mitig inflammatori respons experiment myocard | D001327;D009205 | T047 |
34,678,108 | current opinion diagnosi manag non function pituitari adenoma non function pituitari adenoma nfpas clinic silent tumor second common pituitari adenoma surgeri mainstay treatment yet effect medic treatment | D000236;D010911 | T191 |
34,678,106 | analges prescript receiv patient commenc boa model care osteoarthr swedish nation registri studi match refer clinic guidelin benchmark background purpos swedish clinic guidelin osteoarthr oa priorit patient educ exercis necessari weight reduct consid adjunct pharmacolog intervent contrariwis investig proport type dispens analges prescript sweden receiv patient year commenc non pharmacolog primari care intervent oa compar general popul furthermor analyz proport analges prescript dispens compar guidelin public term concord clinic guidelin recommend patient method patient hip knee oa n better manag oa nation qualiti regist receiv non pharmacolog intervent primari care includ oa cohort age sex resid match refer cohort n form swedish total popul regist base period year prior inclus oa cohort swedish prescrib drug regist data link oa refer cohort result compar refer cohort distinct larger proport oa cohort dispens prescript type analges increas exponenti year prior commenc non pharmacolog intervent sinc guidelin public proport oa cohort dispens prescript analges prior non pharmacolog primari care intervent concord increas ci furthermor dispens prescript concord decreas non select nsaid ci weak opioid ci glucosamin ci hyaluron acid ci discord increas strong opioid ci glucocorticoid intra articular inject hip oa ci interpret sweden dispens prescript analges common occur initi non pharmacolog primari care intervent oa reduc modest guidelin public priorit nonpharmacolog pharmacolog intervent addit modest improv occur steppedcar priorit analges prescript type howev futur strategi requir curb increas strong opioid prescript oa glucocorticoid intra articular inject hip oa | D010818 | T057 |
34,678,105 | follow care barrier patient orofaci cleft aim studi evalu whether patient cleft age associ syndrom cleft phenotyp travel distanc affect follow rate | D002971;D002972 | T019 |
34,678,103 | practic guidelin diagnosi covid associ pulmonari aspergillosi intens care set coronavirus diseas covid associ pulmonari aspergillosi capa new diseas character secondari aspergillus mold infect patient covid primarili affect patient covid critic state acut respiratori distress syndrom requir intens care mechan ventil capa higher mortal rate covid pose serious threat affect individu covid potenti risk factor capa alreadi claim massiv death toll worldwid sinc outbreak decemb second wave current progress toward peak third wave devast pandem expect follow therefor earli accur diagnosi capa utmost import effect clinic manag high fatal diseas howev uniform criteria diagnos capa intens care set therefor base review exist inform experi propos new criteria form practic guidelin diagnos capa focus point relev intensivist pulmonari critic care physician main highlight guidelin includ role capa appropri test specimen clinic risk factor comput tomographi thorax non cultur base indirect direct mycolog evid diagnos capa intens care unit guidelin classifi diagnosi capa suspect possibl probabl categori facilit clinic decis make hope practic guidelin adequ address diagnost challeng capa provid easi use practic algorithm clinician rapid diagnosi clinic manag diseas | D000086382;D055732;D012128 | T047;T067 |
34,678,102 | multimod imag genet primari mucos melanoma respons treatment mucos melanoma mms rare aggress tumor aris melanocyt mucos tissu line respiratori gastrointestin urogenit tract mms occur th th decad life mms may asymptomat may also caus bleed pain itch depend site origin asymptomat oligosymptomat natur difficulti visual case often advanc tumor patient present mm stage vari depend site primari tumor simplifi stage system allow classif clinic local diseas stage region nodal involv stage ii distant metastasi stage iii mm differ genet cutan counterpart common driver cutan melanoma b raf proto oncogen serinethreonin kinas braf lower mutat rate mm wherea mutat gene includ kit proto oncogen receptor tyrosin kinas kit splice factor b subunit gene sfb common mm complet resect best curat option howev surgic intervent wide local excis negat margin may difficult attain local anatomi extent diseas addit despit aggress surgic resect patient develop local recurr metastat diseas recent advanc treatment melanoma includ immunotherapi target therapi unfortun mms relat poor prognosi overal year surviv rate onlin supplement materi avail articl rsna | D008545;D012878 | T191 |
34,678,101 | ventil perfus scan primer practic radiologist lung scintigraphi ventil perfus vq scan one common perform studi nuclear medicin owe variabl clinic applic differ department workflow mani traine comfort interpret result studi articl provid simplifi overview vq imag includ review techniqu interpret method establish emerg clinic applic author review role vq imag evalu acut chronic pulmonari embol includ role spectct compar vq scan ct angiographi addit varieti applic pulmonari scintigraphi discuss includ congenit heart diseas pretreat plan lung cancer emphysema posttranspl imag bronchiol obliteran less common vascular nonvascular patholog condit may detect vq scan articl help radiologist resid interpret result vq scan understand various potenti clinic applic studi onlin supplement materi avail articl rsna | D011655;D000076665 | T047;T060;T046 |
34,678,095 | epitop map anti cd monoclon antibodi c mab use alanin scan mutagenesi surfac plasmon reson cd type transmembran protein express various kind normal cancer cell includ pancreat breast oral cancer cd associ cancer progress metastas treatment resist cd consist exon various isoform exist due altern splice central exon splice variant show cancer specif express pattern relat prognosi patient cancer therefor cd target therapi attract attent previous studi establish anti cd monoclon antibodi c mab igg kappa use flow cytometri western blot immunohistochemistri immun mice cdv ectodomain studi investig bind epitop c mab use enzym link immunosorb assay elisa surfac plasmon reson spr synthes peptid elisa result use delet mutant show c mab react amino acid aa aa cd examin c mab epitop use elisa point mutant aa cd demonstr c mab epitop compris thr asp val spr point mutant aa cd demonstr c mab epitop compris thr asp asp asp val togeth c mab epitop determin locat exon cd | D000409;D020349 | T116;T121;T063;T123 |
34,678,093 | epitop map cancer specif anti podocalyxin monoclon antibodi pcmab use enzym link immunosorb assay surfac plasmon reson podocalyxin podxl type transmembran sialoglycoprotein overexpress human cancer includ breast oral lung podxl promot tumor progress express associ poor prognosi sinc podxl express normal cell includ kidney podocyt vascular endotheli cell vec cancer specif monoclon antibodi mab necessari reduc advers effect antibodi therapi podxl express cancer previous establish cancer specif mab podxl pcmab mous igm kappa immun mice solubl podxl produc ln glioblastoma cell pcmab react podxl express cancer cell react vec studi investig epitop pcmab use flow cytometri surfac plasmon reson spr enzym link immunosorb assay elisa result spr reveal pcmab epitop consist thr arg gli gli gli ser gli asn pro thr contrast result elisa reveal pcmab epitop consist arg gli gli gli ser gli asn pro result demonstr cancer specif epitop recogn pcmab | D000911;D009369 | T129;T191;T116 |
34,678,091 | moral injuri moral resili health care worker covid pandem background coronavirus covid pandem place unpreced strain us health care system put health care worker hcws increas risk experienc moral injuri mi moral resili mr abil preserv restor integr propos resourc mitig detriment effect mi among hcws object object studi investig preval mi among hcws identifi relationship among factor predict mi determin whether mr act buffer design web base exploratori survey settingsubject hcws research network us mid atlant region measur survey item includ outcom moral injuri symptom scale health profession miss hp predictor includ demograph item deriv rushton moral resili scale rmrs ethic concern index eci result sixti five percent respond provid covid care overal preval clinic signific mi hcws nurs report highest occurr higher score eci item signific posit associ higher mi symptom p mi among hcws signific relat follow mr score eci score religi affili year profess mr moder effect year experi mi conclus hcws experienc mi pandem mr offer promis individu resourc buffer detriment impact mi research need understand cultiv mr reduc eci understand system level factor prevent mi symptom us hcws | D000086382;D013313 | T048;T047;T067 |
34,678,090 | measur eat patholog use minnesota multiphas person inventori mmpi eat disord preval among colleg student popul although previous iter instrument includ specif measur eat patholog minnesota multiphas person inventori mmpi includ specif scale ie eat concern eat assess problemat eat behavior current studi examin mmpi assess eat patholog among undergradu women pattern emerg symptom intern psychopatholog mmpi general associ symptom eat disord howev newli includ eat scale demonstr strongest associ area eat dysfunct hierarch regress analys suggest eat scale ad substanti increment predict util mmpi scale combin assess eat patholog classif accuraci statist yield high sensit specif coeffici predict eat disord risk eat scale score cutoff higher find support use mmpi assess eat patholog colleg women although perform men women colleg age remain studi | D008950;D001523 | T048;T170 |
34,678,089 | limit function climacter syndrom systemat literatur review use icf studi first four preparatori studi process develop intern classif function disabl health icf core set climacter syndrom aim identifi perimenopaus postmenopaus limit function report scientif literatur | D005831;D047648 | T039;T047 |
34,678,088 | pdgfr modul aerob glycolysi osteosarcoma hos cell via pikaktmtorc myc pathway osteosarcoma malign tumor abund vascular tissu rich blood suppli may signific impact metabol characterist pdgfr membran receptor high express osteosarcoma cell vascular wall cell effect osteosarcoma metabol need studi studi discuss effect mechan action pdgfr glucos metabol human osteosarcoma hos cell gsea pearson correl test ppi correl analysi indic posit regul pdgfr aerob glycolysi osteosarcoma result qpcr western blot confirm predict bioinformat glucos metabol experi prove pdgfpdgfr could effect promot aerob glycolysi osteosarcoma cell addit mitochondri membran potenti experi prove metabol chang trigger pdgfr caus mitochondri damag pik pathway inhibitor ly mek pathway inhibitor u warburg effect inhibitor dca use perform western blot glucos metabol experi result show pdgfbbpdgfr main activ pikaktmtorc myc pathway promot aerob glycolysi osteosarcoma hos cell newli elucid role pdgfr provid novel metabol therapeut target osteosarcoma | D001859;D012516 | T191 |
34,678,086 | detect idiograph person chang person chang across lifespan strong evid regard mechan respons person chang remain elus studi person chang life event exampl suggest person difficult chang two key issu assess person chang first chang model optim popul level individu level effect ignor heterogen pattern chang second optim chang mean level self report fail incorpor method assess person dynam use chang varianc correl multivari time seri data often proceed chang mean level make varianc chang detect promis techniqu studi chang use sampl n particip total n assess week week test permut base approach detect individu level person chang multivari time seri compar result event base method assess chang find non trivial number particip show chang cours year littl associ chang point life event experienc conclud highlight import idiograph dynam investig chang | D010551;D010554 | T048;T041 |
34,678,085 | associ hospit magnet status pay perform penalti center medicar medicaid servic pay perform pp program aim improv hospit care financi incent care qualiti patient outcom magnet recognit potenti pathway improv nurs work environ associ better patient outcom pp program score whether indic higher qualiti substanti enough avoid penalti therebi impact hospit reimburs unknown cross section studi use nation sampl hospit examin relationship hospit magnet status pp penalti pp program hospit readmiss reduct program hospit acquir condit hac reduct program hospit valu base purchas vbp program magnet hospit match non magnet hospit account organiz characterist includ hospit size locat post match logist regress model use comput hospit odd penalti nation sampl hospit hospit experienc pp penalti magnet hospit less like penal vbp program compar match non magnet counterpart vs magnet status associ lower odd vbp penalti relat non magnet hospit lower pp program penalti one benefit associ achiev magnet status otherwis maintain high qualiti nurs work environ | D019984;D012052 | T080;T170;T081 |
34,678,082 | folic acid inhibit vasculogen mimicri esophag cancer cell line eca one target epha degre vasculogen mimicri vm correl prognosi esophag cancer folic acid supplement could decreas esophagus cancer death among popul studi aim explor effect folic acid vm format esophag cancer cell target human esophag squamous cancer cell line eca cultur differ concentr folic acid gml cell count kit cck assay use measur cell prolifer amount vm effect differ concentr folic acid observ target gene screen sever possibl target gene includ mmp mmp epha cad ln employ revers transcript quantit polymeras chain reaction rt qpcr final western blot analysi use verifi target protein conclus studi found folic acid inhibit format vm eca cell one target protein epha | D004938;D000077277 | T191 |
34,678,076 | workplac leav breastfeed durat among postpartum women object examin associ workplac leav length breastfeed initi continu month method analyz data site unit state pregnanc risk assess monitor system site specif popul base surveil system sampl women recent live birth month birth use multivari logist regress examin associ leav length vs month breastfeed outcom result among postpartum women plan return job pregnanc report take unpaid leav report paid leav report unpaid paid leav report leav approxim two third women report take less month leav although women initi breastfeed women continu breastfeed month respect shorter leav length month whether paid unpaid associ lower preval breastfeed month compar month leav conclus women less month leav report shorter breastfeed durat women month leav j public health https doiorgajph | D049590;D014931 | T098;T079;T101 |
34,678,075 | next generat food research use meta omic approach character microbi communiti along food chain microorgan exist along food chain impact qualiti safeti food posit negat way identifi understand behavior microbi communiti enabl implement prevent correct measur public health food industri set current cultur depend microbi analys time consum target specif subset microb howev greater use cultur independ meta omic approach potenti facilit thorough character microbi communiti along food chain inde method shown potenti contribut outbreak investig ensur food authent assess spread ofantimicrobi resist track microbi dynam ferment process uncov factor along food chain impact food qualiti safeti review examin communiti base approach particular applic sequenc base meta omic strategi character microbi communiti along food chain | D020387;D064307 | T070;T001;T032;T028 |
34,678,074 | covid pandem influenc medic oncolog provid percept telehealth video visit covid pandem necessit rapid expans telehealth use oncolog specialti prior util low part barrier perceiv provid understand chang percept medic oncolog provid pandem critic continu expans improv telehealth cancer care studi design identifi medic oncolog provid percept telehealth video visit influenc covid pandem | D000086382;D010820;D017216 | T097;T058;T047;T067 |
34,678,049 | hydrogen product alter chicxulub crater impact breccia potenti energi sourc subsurfac microbi ecosystem sulfat reduc popul thermophil grew porous permeabl nich within glass bear impact breccia chicxulub impact crater microbi communiti grew impact generat hydrotherm system vent seafloor sever hundr meter beneath sea surfac potenti electron donor metabol hydrocarbon although strong c isotop signatur sourc exist model calcul explor suggest alter glass within impact breccia may produc h suffici quantiti popul growth hydrotherm system cool thermophil temperatur although sensit oxid state iron melt rock prior hydrotherm alter secondari miner assemblag high water rock ratio temperatur c h yield insuffici maintain popul hydrogenotroph sulfat reduc bacteria yield doubl higher proport ferrous iron c reduc rock ie highest proport ferrous iron allow form andradit observ core sampl produc copious amount h temperatur window thermophil hyperthermophil mixtur melt rock carbon observ breccia matric produc somewhat less h onset massiv h product shift higher temperatur ie lower wr | D017753;D064307 | T082;T001;T032;T028;T070 |
34,678,047 | gut microbiom connect diet glucos homeostasi diseas type diabet rate continu rise unab underscor need better understand etiolog potenti therapeut option avail diseas gut microbiom play role glucos homeostasi diabet associ alter gut microbiom given consumpt western diet associ increas metabol diseas western diet alter gut microbiom plausibl chang gut microbiota mediat dysregul glucos homeostasi review highlight signific mechan gut microbiom influenc glucos regul includ chang gut permeabl gut brain signal product bacteria deriv metabolit like short chain fatti acid bile acid better understand pathway could lead develop novel therapeut target gut microbiom order restor glucos homeostasi metabol diseas | D003924;D000069196 | T007;T047;T001 |
34,678,044 | radiat oncolog altern payment model larg urban academ center futur implic patient provid radiat oncolog altern payment model ro apm develop center medicar medicaid innov part center medicar medicaid servic vehicl optim valu patient undergo radiat therapi shift reimburs away fee servic toward prospect bundl payment system ro apm intend bend cost curv radiat oncolog preserv even enhanc outcom prior larg scale polici initi natur magnitud ro apm impact care deliveri vari substanti depend host local factor includ practic set urban academ center play key role radiat oncolog spearhead innov manag complic case train next generat radiat oncologist often care vulner patient popul thus protect patient access high qualiti cancer care crucial character ro apm project impact larg urban academ institut implement includ possibl unintend advers consequ provid overview seismic chang radiat oncolog reimburs discuss uniqu potenti implic larg urban academ institut mean facilit necessari prepar inform futur revis model | D018787 | T091 |
34,678,043 | biolog divers ant alkaloid ant outstand capac mediat inter intraspecif interact produc structur divers metabolit numer secretori gland sinc murray blum pioneer studi date grow interest arthropod toxin natur product dozen differ alkaloid class report approxim ant genera five subfamili peak divers within myrmicina tribe solenopsidini ant alkaloid function venom deriv gland altern function use defens eg alarm repel offens eg toxin also serv antimicrobi pheromon provid overview ant alkaloid divers function evolutionari perspect conclud direct integr research need suggest compar phylogenet illumin compound diversif molecular approach elucid genet origin biolog context inform natur histori remain critic research focal speci also guid appli research | D000470;D001000 | T121;T109;T123;T131;T204 |
34,678,042 | develop framework cultur scientif research scientif research cultur challeng enter differ aspect cultur may act barrier entri point differ peopl recognit barrier entri point requir identifi aspect cultur scientif research synthes singl descript framework systemat literatur review encompass two prong search strategi descript map idea consensus build perform identifi aspect scientif research cultur result cultur scientif research csr framework compos cultur aspect categor either practic normsexpect valuesbelief addit evid valid collect survey ask biolog research indic aspect framework relev experi research major survey respond n perceiv aspect csr framework relev biolog research framework provid consist structur describ experi peopl engag cultur scientif research literatur review includ literatur multipl disciplin csr framework broad applic futur applic csr framework includ identifi possibl barrier entri point experienc group current underrepres scientif research | D013334 | T098;T081 |
34,678,041 | support scientif practic model base inquiri student eye view grappl data uncertainti communiti laboratori experi model scientif practic support creativ reason motiv inquiri facilit communiti sens make paper explor student perspect model undergradu laboratori cours authent inquiri model aim bio propos test revis model conduct compar case studi eight student semest student describ use model support multipl form scientif reason hypothesi generat recount challeng deal uncertainti integr divers idea also describ challeng push think overal student report feel sens scientif authent agenc model experi addit provid depth look two student whose uniqu experi aim bio emphas variabl way model support inquiri learn claim model emerg legitim practic among student aim bio curriculum encourag divers student model provid opportun student grappl uncertainti foster collabor student suggest biolog educ consid model base inquiri allow student particip scienc way support interest identif ultim persist scienc technolog engin mathemat field | D007753;D013334 | T098;T093;T073;T081 |
34,677,984 | thermodynam kinet aggreg flexibl peripher membran protein biomembran remodel essenti cellular traffick membran bind peripher protein play key role signific membran remodel endo exocytosi often due aggreg mani protein direct membran mediat interact understand process via comput simul extrem challeng protein membran system involv time length scale make atomist simul impract coars grain model fall short resolv dynam physic effect protein membran flexibl develop coars grain model bilay membran bestrew rotate symmetr flexibl protein parametr reflect local curvatur later dynam protein investig kinet equilibrium distribut free energi landscap govern format breakup protein cluster surfac membran demonstr flexibl protein well surfac concentr play decid role high select macroscop aggreg behavior | D013816 | T090 |
34,677,978 | reproduc determin high densiti lipoprotein proteotyp high densiti lipoprotein hdl heterogen mixtur blood circul multimolecular particl contain mani differ protein lipid rnas recent advanc mass spectrometri base proteotyp analysi show promis analysi proteoform across larg patient cohort order creat requir spectral librari enabl data independ acquisit dia strategi hdl isol plasma patient multipl physiolog hdl state hdl proteom spectral librari consist protein group peptidoform establish perform dia strategi benchmark detect hdl proteotyp differ healthi individu cohort patient suffer diabet mellitus type andor coronari heart diseas bioinformat interrog data use generat spectral librari show dia approach enabl robust hdl proteotyp determin hdl peptidoform analysi enabl use spectral librari allow identif post translat modif apoa could affect hdl function technic point view data analysi show protein peptid quantiti current discrimin differ hdl proteotyp peptidoform without enrich togeth dia base hdl proteotyp enabl robust digit hdl proteotyp basi analysi larger clinic cohort | D008075;D040901 | T091;T116;T123 |
34,677,977 | titania model free interpret residu dipolar coupl context organ compound residu dipolar coupl rdcs becom increas import addit nmr paramet structur elucid organ compound usual use fit procedur discrimin comput structur accord rdcs other rule thus determin configur requir prior structur inform direct use rdcs restraint construct structur base rdcs recent begun also organ compound protocol publish though use vector dynam inform avail multialign data set direct joint determin conform configur organ compound propos current studi show employ data even flat random start structur converg correct configur structur employ multipl align data set iter procedur requir term number rdcs align media necessari discuss detail | D009930 | T109 |
34,677,976 | molecular structur vibrat spectra water molecul sorb poli methoxyethylacryl reveal molecular dynam simul molecular dynam md simul water sorption poli methoxyethylacryl pmea carri elucid hydrogen bond h bond structur water molecul side chain pmea pmea model incorpor lone pair virtual site carbonyl methoxi oxygen side chain pmea key interact site biocompat polym newli develop pmea model well reproduc experiment observ featur infrar spectra hydrat polym well radial distribut function water molecul contact polym calcul ab initio md simul md simul result reveal water molecul tend form h bond carbonyl oxygen methoxi oxygen side chain pmea simultan enhanc head tail stack structur side chain low concentr rang water penetr water pmea structur gradual increas water water h bond state promot format water cluster even equilibrium water content | D056004;D014867 | T044;T066;T121;T197 |
34,677,970 | design synthesi structur activ relationship molecular dock herbicid evalu cinnamoyl hydroxycyclohex en one deriv novel hydroxyphenylpyruv dioxygenas inhibitor cinnam acid isol cinnamon bark natur product excel bioactiv effect bind cyclohexanedion form novel hydroxyphenylpyruv dioxygenas hppd inhibitor accord activ sub structur combin principl seri novel hydroxi cinnamoyl en one deriv design synthes titl compound character infrar h nmr c nmr hrms vitro inhibitori activ hppd verifi compound ii show activ half maxim inhibitori concentr ic valu superior mesotrion vitro preliminari herbicid activ test demonstr compound good herbicid activ especi compound ii concentr g aiha bind mode hppd molecular dock indic two oxygen compound ii form bident interact metal ion benzen ring form accumul effect phe phe result molecular dynam simul show compound ii exhibit stabl bind abil hppd mesotrion studi provid insight develop natur effici herbicid futur | D015111;D006540 | T131;T116;T126 |
34,677,968 | berberin molecular recognit parallel myc g quadruplex solut medicin natur product berberin one activ studi pursu g quadruplex g ligand major g quadruplex form promot region myc oncogen mycg attract drug target promin exampl model structur parallel g quadruplex g target berberin deriv activ develop howev analogu design base previous crystal structur berberin bind dimer parallel g quadruplex herein show solut bind mode stoichiometri berberin substanti differ crystal structur berberin bind monom mycg use base recruit mechan revers orient posit charg convex side actual posit tetrad center structur provid physiolog relev basi futur structur base ration design g target berberin deriv studi demonstr crucial valid ligand dna interact | D054856;D016259 | T086;T028 |
34,677,966 | contemporari approach discoveri develop broad spectrum natur product prototyp control coronavirus press need sar cov control led reassess strategi identifi develop natur product inhibitor zoonot high virul rapid emerg virus review articl address contemporari approach involv comput chemistri natur product np protein databas mass spectrometri ms deriv target ligand interact analysi util expedit interrog np structur minim time expens extract purif screen biosafeti laboratori bsl laboratori unparallel structur divers complex nps extraordinari resourc discoveri develop broad spectrum inhibitor viral genera includ betacoronavirus contain mer sar sar cov common cold two key technolog advanc creat uniqu opportun identif np prototyp greater effici applic structur databas nps target protein applic modern ms techniqu assess protein ligand interact direct np extract approach develop year allow identif isol uniqu antivir ligand without immedi need bsl facil overal goal improv success rate np base screen focus resourc sourc materi higher likelihood success simultan provid opportun discoveri novel ligand select target protein involv viral infect | D055808 | T062 |
34,677,964 | impact dietari vitamin supplement growth molt antioxid capabl immun juvenil chines mitten crab eriocheir sinensi metabolit vitamin receptor vitamin vit indispens fat solubl nutrient associ skelet miner health mammal howev associ well studi econom import crustacean six level vit isonitrogen isolipid diet use feed eriocheir sinensi rang optim vit requir iukg base growth crab fed iukg vit show best growth perform vit dose signific increas antioxid capac hepatopancrea intestin optim molt innat immun via quantit polymeras chain reaction analysi transcriptom analys indic vit could alter protein process endoplasm reticulum steroid biosynthesi antigen process present shown enzym link immunosorb assay vit could improv vitamin receptor retino acid receptor c type lectin concentr dihydroxi vit content serum signific higher iukg vit studi suggest dietari vit metabolit regul molt innat immun crab | D000975;D003386 | T044;T121;T123;T039;T204 |
34,677,963 | nitrogen balanc bioavail amino acid spirulina diet fed wistar rat spirulina wide known consum health food main dri product sinc data raw spirulina protein sourc insuffici nutrit valu dri raw spirulina diet wistar rat determin digest coeffici signific lower dri raw spirulina diet casein diet although biolog valu dri raw spirulina diet signific higher casein diet protein digest correct amino acid score raw spirulina signific higher dri spirulina addit amino acid profil portalven blood spirulina diet fed rat reveal ala gli val leuil mark decreas system circul result suggest dri raw spirulina diet may effect protein sourc also supplement support proteinamino acid bioavail | D000596;D053545 | T116;T007;T121;T123 |
34,677,960 | herbivor induc z hexen ol airborn signal promot direct indirect defens tea camellia sinensi light tea camellia sinensi popular nonalcohol beverag worldwid cultiv tea plant suscept herbivor pathogen serious affect tea yield qualiti previous report show z hexenol potenti effici defens substanc howev molecular mechan mediat z hexenol signal tea plant result effect plant defens remain uncharacter clarifi signal mechan z hexenol light involv gene transcript metabolit level assess respect studi demonstr tea plant rapid continu releas z hexen ol respons insect infest z hexen ol absorb adjac healthi plant would convert three insect defens compound z hexenyl glucosid z hexenyl primeverosid z hexenyl vicianosid identifi laboratori synthes standard moreov z hexen ol also activ synthesi jasmon acid enhanc insect resist tea plant addit continu light treatment induc accumul z hexenyl glycosid henc z hexenol serv light regul signal molecul activ system defens adjac plant studi reveal molecular mechan biotic abiot factor synergist regul signal function herbivor induc plant volatil plant provid valuabl inform futur comprehens analys system defens mechan plant | D028241;D055549 | T002;T109 |
34,677,958 | probiot bacillus cereus allevi dextran sulfat sodium induc coliti mice improv intestin barrier function anti inflamm gut microbiota modul dysbiosi lead continu progress inflammatori bowel diseas ibd howev current therapeut approach ibd limit efficaci associ various side effect studi focus explor posit effect new bacillus cereus b cereus strain hmpm coliti mous model elucid under molecular mechan coliti symptom allevi b cereus administr evidenc decreas bodi weight loss colon length shorten diseas activ index score histopatholog score b cereus mitig intestin epitheli barrier damag upregul tight junction protein express moreov b cereus exert anti inflammatori effect regul macrophag polar suppress tlr nf b nlrp inflammasom signal pathway b cereus also rebalanc damag gut microbiota thus molecular mechan allevi coliti b cereus treatment involv regul tlr nf b nlrp inflammasom signal pathway intestin mucos barrier modul gut microbiota composit | D003092;D000069196;D019936 | T007;T047;T001 |
34,677,956 | materi approach improv electrochem sensor perform electrochem sensor emerg import diagnost tool recent year due simplic eas use compar instrument analysi method use complic experiment data analysi techniquessuch mass spectrometri nuclear magnet reson nmr spectrophotometr method chromatographyelectrochem sensor show promis use wide rang real time situ applic pharmaceut test environment monitor medic diagnost order identifi analyt complex andor biolog sampl materi use electrod materi chemic select layer evolv throughout year optim analyt perform electrochem sensor increas sensit select linear rang perspect attent focus differ type materi use electrochem sens includ new combin well studi materi well novel strategi enhanc perform sens devic perspect also discuss exist challeng field futur strategi address challeng | D015374;D055664 | T059;T075 |
34,677,955 | molybdenum bioavail asymbiot nitrogen fixat soil rais iron oxyhydr oxid mediat free radic product nitrogen n fixat soil close link microbi mediat molybdenum mo cycl therefor elucid mechan factor affect mo bioavail crucial understand n fixat demonstr long term year manur fertil increas microbi divers content short rang order iron oxyhydr oxid rais mo bioavail time storag increas abund nif h gene nitrogenas activ nanos iron oxyhydr oxid ferrihydrit goethit hematit nanoparticl play dual role soil mo cycl concert microorgan rais mo bioavail catalyz hydroxyl radic ho product via fenton reaction ii increas mo retent associ nanos iron oxyhydr oxid summari long term manur fertil rais stock bioavail mo probabl also micronutri increas iron oxyhydr oxid reactiv intensifi asymbiot n fixat increas abund nif h gene nitrogenas activ work provid strategi increas biolog n fixat agricultur ecosystem | D008982;D009586 | T040;T196;T123 |
34,677,954 | sens oxygen sensor develop applic activ base assay direct monitor hif heterodimer convent hypoxia induc factor hif activ prolyl hydroxylas domain enzym phd inhibit monitor gene report assay principl reli monitor upstream event hif stabil downstream transcript activ develop novel approach direct sens hif activ monitor heterodimer hifhif subunit constitut function hif transcript factor two live cell base biosensor assay setup design util function complement split nanoluciferas tool measur hifhif protein protein interact result stabil hif hif assay setup well format optim durat h hekt transfect protocol introduc optim configur hifhif fusion protein new bioassay outperform hypoxia respons element base gene report assay current state art assay term sensit applic demonstr use panel phd inhibitor includ roxadustat molidustat daprodustat desidustat vadadustat fg concentr respons curv generat allow deriv potenc ec efficaci e max data broad applic biosensor establish via appli hypoxia mimet cocl iron chelat desferrioxamin proteasom inhibitor mg og mimet dimethyloxalylglycin assay indic concentr depend effect | D011393;D014157 | T116;T126;T123 |
34,677,952 | declin trend china futur cropland n emiss due reduc cropland area cropland largest anthropogen sourc nitrous oxid n power greenhous gas contribut grow atmospher n burden howev studi provid comprehens depict futur cropland n emiss nation scale due lack accur cropland predict data herein present newli develop distribut land use chang predict model high precis predict nation scale land use chang high precis land use data provid opportun elucid chang cropland area affect magnitud spatial distribut n emiss china cropland result show declin trend china total cropland n emiss tg nyear tg nyear consist cropland area reduct ha ha howev approxim calcul citi china would emit present level furthermor differ land use climat chang scenario would import impact cropland n emiss grain green plan implement china would effect control emiss approxim | D000383;D000074382 | T090;T197 |
34,677,949 | herbicid induc shift periphyton communiti composit indirect affect feed activ physiolog gastropod grazer physella acuta herbicid well known unintend effect freshwat periphyton communiti larg knowledg gap howev exist regard indirect herbicid impact primari consum chang qualiti periphyton food sourc ie diet relat effect address gap grazer physella acuta gastropoda fed day periphyton grew day presenc absenc herbicid diuron gl quantifi chang feed rate growth rate energi storag neutral lipid fatti acid nlfas p acuta periphyton biomass cell viabil communiti structur fas serv proxi food qualiti support mechanist interpret grazer respons diuron chang alga periphyton communiti fatti acid profil indic alter food qualiti could explain differ snail feed rate compar control snail growth rate despit effect size statist signific chang nlfa profil p acuta alter result indic herbicid chang food qualiti periphyton shift alga composit may affect physiolog grazer | D006540;D000074284 | T131;T001 |
34,677,947 | automat cocryst detect raman spectral deconvolut base novelti analysi cocryst import molecular adduct mani advantag mean modifi physicochem properti activ pharmaceut ingredi includ tast mask improv solubl bioavail stabil result discoveri new cocryst great interest commerci drug discoveri program time consum manual analysi larg volum data emerg larg scale cocryst screen program prepar pose challeng raman spectroscopi shown discrimin cocryst physic mixtur easi autom allow rapid screen larg number potenti cocryst spectral featur encod inform often subtl eg slight chang peak posit intens employ autom signal process routin base spars decomposit algorithm speed data process step maintain accuraci train spectroscopist use algorithm screen potenti cocryst prepar found use comput generat threshold could achiev clear classif cocryst physic mixtur less minut compar sever hour manual | D004364;D013059 | T070;T121;T059 |
34,677,946 | differ electrochem perform pt base catalyst use polym electrolyt membran fuel cell liquid half full cell substanti amount research effort direct toward develop pt base catalyst higher perform durabl convent polycrystallin pt nanoparticl achiev high power innov energi convers system current attent paid toward expand electrochem activ surfac area ecsa catalyst increas intrins activ oxygen reduct reaction orr howev despit innumer effort carri explor possibl achiev focus rotat disk electrod rde half cell relat result adapt membran electrod assembl mea full cell actual oper condit fuel cell thus uncertain whether advanc catalyst use substitut practic fuel cell applic improv catalyt perform real life fuel cell still necessari therefor practic industri point view goal review compar orr catalyst perform durabl half full cell provid differenti approach durabl concern half full cell share new perspect strateg design use induc addit perform full cell devic | D010984;D011108 | T104;T122;T196 |
34,677,945 | novel insight dissolv organ matter process pathway coastal confin aquif system highest known concentr geogen ammonium high level geogen ammonium groundwat high neglect nitrogen pool coastal aquat system although organ matter om miner known signific influenc geogen ammonium enrich detail mechan under ammonium enrich base dissolv organ matter dom character coastal aquif system remain unclear studi character optic molecular signatur dom coupl hydrogeochemistri multipl isotop hocn elucid detail mechan under anomal high ammonium coastal confin aquif system pearl river delta exhibit highest report geogen ammonium concentr groundwat earth identifi three dom fluoresc compon marin humic like compon c two humic like compon c c autochthon om first process c compon transform c c compon term molecular class process pathway bacteri algal deriv om aliphat compound high unsatur low compound identifi high unsatur low compound accumul main product compound contain two three n atom process compound one n atom gradual accumul degrad cho compound ammonium mgl n gradual enrich due decomposit chon chon chon cho compound owe longer resid time less frequent fresh water flush produc ammonium retain aquif long term result contrast dom characterist togeth differ deposit hydrogeolog condit give rise higher level geogen ammonium coastal confin aquif system compar inland alluvi lacustrin confin aquif system knowledg first studi character dom relationship geogen ammonium coastal aquif system | D064751;D060587 | T082;T104;T197;T081;T070 |
34,677,944 | enthalp entrop select water small ion polyamid membran polyamid revers osmosi nanofiltr membran extens util water purif desalin process molecular detail govern water solut permeat membran fulli understood studi appli transit state theori transmembran permeat systemat break intrins permeabl water small ion loos tight polyamid nanofiltr membran enthalp entrop compon use eyr type equat analyz trend compon elucid molecular phenomena induc water salt monoval dival monoval monoval select differ ph valu result suggest pore either small contain electrostat repel mouth thermal activ ion form ion dehydr less like promot entrop driven select steric exclus hydrat ion instead larger uncharg pore enabl ion dehydr induc enthalp select driven differ ion hydrat properti also demonstr electrostat interact cation intrapor carboxyl group hinder salt permeabl increas enthalp barrier transport last permeat test monoval cation loos tight polyamid membran expos opposit reject trend support phenomenon ion dehydr larg subnanopor | D009757;D018508 | T052;T057;T122;T109 |
34,677,943 | dissect biolog synthet soft hard interfac tissu like system soft hard materi interfac exhibit mismatch behavior mismatch chemic biochem reactiv mechan respons environment adapt leverag mitig differ yield interfaci process difficult achiev inapplic pure soft pure hard phase explor interfaci mismatch associ bio chemic mechan physic process may yield numer opportun fundament studi applic manner similar semiconductor heterojunct contribut solid state physic semiconductor industri past decad review explor fundament chemic role principl involv design interfac bio chemic evolut adapt buffer zone discuss spectroscop microscop bio chemic comput tool requir uncov chemic process confin hidden soft hard interfac propos soft hard interact framework use discuss soft hard interfaci process multipl system across sever spatiotempor scale focus tissu like materi devic end review propos sever new scientif engin approach leverag soft hard interfaci process involv biointerfac composit explor new applic composit | D012666 | T073 |
34,677,940 | engin facil aptam molecul doctor hairpin contain motif enabl accur imag kill cancer cell herein subt engin ph membran receptor dual activat aptam therapeut bispecif tumor cell imag situ drug releas util hairpin contain motif acid respons element complementari tumor target aptam name aptam molecul doctor ph apt md specif ph apt md consist two dna strand apt sgcc label af cy end respect strand hairpin contain motif complementari apt sgcc strand partial label bhq middl thus generat cy quench fluoresc af emit fluoresc doubl helix region ph apt md design rich gc base provid site doxorubicin dox intercal target cell encount ph apt md disassembl due specif recognit aptam conform chang motif activ fluoresc reson energi transfer fret signal af cy accompani dox releas situ benefit design hairpin contain motif ph apt md present narrow ph respons rang ph transit midpoint ph furthermor live cell studi reveal stimuli respons fret signal activ ph apt md success achiev hct cell surfac ultralow background enhanc imag contrast cytotox experi prove accur drug releas cell kill realiz target cell acid microenviron facil doubl stimuli respons strategi ph apt md may hold great promis applic precis diagnosi therapi cancer cell | D052157;D009369 | T191;T114 |
34,677,935 | small molecul exploit hidden structur featur within rna repeat expans caus calsftd rescu patholog hallmark hexanucleotid repeat expans ggggcc r g c exp within intron corf caus genet defin amyotroph later sclerosi frontotempor dementia collect name calsftd repeat expans caus neurodegener via deleteri phenotyp stem r g c exp rna gain loss function mechan r g c exp rna fold hairpin structur repeat nucleotid gg intern loop g quadruplex structur report identif small molecul cb select bind hairpin form r g c exp interest small molecul bind previous unobserv conform rna form nucleotid gg intern loop reveal seri bind structur studi nmr molecular dynam simul suggest r g c exp hairpin interconvert intern loop process strand slippag provid experiment evid cb bind inde shift equilibrium toward gg intern loop conform inhibit mechan drive calsftd pathobiolog repeat associ non atg translat format stress granul defect nucleocytoplasm transport various cellular model calsftd | D000690;D057180 | T048;T047 |
34,677,934 | prepar magnet hydrogel microparticl cation surfac cell assembl perform cation magnet hydrogel microparticl high retent cell surfac prepar use two step procedur use magnet hydrogel microparticl cell cluster cell aggreg prepar effect cross link poli vinyl alcohol pva hydrogel microparticl contain iron oxid nanoparticl prepar diamet microparticl rang nm water solubl cation polym contain trimethyl ammonium tma group phenylboron acid pba group synthes surfac modif microparticl regul composit electr neutral phosphorylcholin group introduc polym coval bond form hydroxi group pva microparticl pba group polym surfac zeta potenti microparticl reflect composit tma group particl respond extern magnet field cluster rapid microparticl adsorb float cell surfac induc cell aggreg quick magnet field appli effect condit diamet cell aggreg increas approxim mm min denser cell aggreg form synergist effect magnet field properti microparticl form cell aggreg continu grow day appli magnet field indic abil cell aggreg prolifer well maintain | D020100;D011108 | T104;T122 |
34,677,933 | magnetoelast immunosensor via antibodi immobil specif detect lysozym lysozym human urin crucial clinic signific indic renal tubular glomerular diseas lysozym detect method reli enzym link immunosorb assay elisa usual tedious procedur meanwhil aptam sensor fluoresc base techniqu lysozym detect emerg recent studi howev method time consum high complex oper even requir exorbit reagent instrument restrict real time clinic monitor diagnost approach therefor rapid low cost lysozym detect method facil prepar still demand modern precis medicin herein propos magnetoelast immunosensor lysozym detect detect chang reson frequenc magnetostrict effect detect system compos magnetoelast chip immobil lysozym antibodi solenoid coil vector network analyz sinc sensor ultrasensit mass chang frequenc offset caus mass chang util detect content lysozym immunosensor evalu possess superior sensit hzg ml term reson frequenc shift rfs addit sensor display outstand perform specif experi show relat lower detect limit ngml convent lysozym detect method elisa chemiluminesc assay fluoresc aptam biosensor | D055910;D015374 | T129;T116;T059;T075 |
34,677,927 | develop integr system site infect detect modern healthcar system face unrel threat microorgan evidenc global outbreak new viral diseas emerg antimicrobi resist rise incid healthcar associ infect hai effect respons threat requir rapid accur diagnost test identifi causat pathogen point care poc test could elimin diagnost uncertainti facilit patient triag minim empir use antimicrobi drug enabl target treatment current standard method howev often fail meet need rapid diagnosi poc set cultur base assay entail long process time requir special laboratori infrastructur nucleic acid na test often limit central hospit due assay complex high cost discuss two new poc test develop group enabl rapid diagnosi infect first nanopcr take advantag core shell magnetoplasmon nanoparticl mpns au shell signific acceler thermocycl via volumetr plasmon light heat convers ii magnet core enabl sensit situ fluoresc detect via magnet clear adopt ferri wheel modul system expedit multisampl parallel minim setup appli covid diagnosi nanopcr detect sar cov rna copyl within min particular nanopcr diagnost accur identifi covid case clinic sampl n valid clinic applic second polar anisotropi diagnost pad system exploit principl fluoresc polar fp detect modal fluoresc probe design alter molecular weight upon recogn target nas event modul probe tumbl rate brownian motion lead chang fp approach robust environment nois benefit ratiometr natur signal readout appli pad detect clinic relev hai bacteria escherichia coli klebsiella pneumonia acinetobact baumannii pseudomona aeruginosa staphylococcus aureus pad assay demonstr detect sensit singl bacterium level determin drug resist virul status summari new test potenti becom power tool rapid diagnosi infecti diseas space requir high skill personnel labor intens analys assay quick cost effect attribut make nanopcr pad well align poc workflow aid physician initi prompt inform patient treatment | D000086742;D005454;D036103;D016133 | T070;T059;T063;T090 |
34,677,921 | clinic summari reason format tool clinic practic medic train patient record often bulki unwieldi necessit creation summari structur summari format add advantag improv organ easier retriev inform howev typic clinic summari format document intermedi deduct link symptomatolog diagnosi extent fall short track cognit process clinician clinic summari reason format faculti paediatr nation postgradu medic colleg nigeria west african colleg physician design track clinic thought reason process clinician consist two major section first section document data histori physic examin earli laboratori report second section record hierarch deduct way reach various level diagnosi definit descript various compon format herein present use format clinic practic clinic train assess traine discuss | D010820 | T097 |
34,677,920 | compound odontoma anterior maxilla associ displac later incisor case report odontoma common odontogen tumor worldwid usual chanc find seen routin dental examin howev progress may associ adjac tooth displac | D009810 | T191 |
34,677,913 | bio deriv surfac layer suitabl long term cycl ni rich cathod lithium ion batteri sinc ni rich cathod materi sensit moistur easili form residu lithium compound degrad cell perform import pay attent select surfac modifi media accord hydroxyapatit ca po oh tooth deriv materi show excel mechan thermodynam stabil select verifi avail hydroxyapatit surfac protect materi lithium dope hydroxyapatit ca li po oh form nm layer react residu lithium compound li ni co al spontan result dramat reduct surfac lithium residu ppm ppm ca li po oh modifi li ni co al electrod provid ultra long term cycl stabil enabl cycl retain initi capac also morpholog degrad micro crack amorph surfac signific suppress presenc ca li po oh layer li ni co al ca li po oh transform caf via ca li po f long term cycl react hf electrolyt addit author densiti function theori dft result explain reason instabl nca caf layer delay micro crack electrochem reaction therefor stabl ca li po f caf layer play pivot role protect li ni co al ultra long cycl stabil | D011211;D008094 | T196;T121;T073 |
34,677,912 | effect captiv vertebr bone microstructur xenarthran mammal captiv specimen museum collect facilit studi rare taxa lifestyl diet lifespan captiv anim differ wild counterpart trabecular bone architectur adapt vivo forc may reflect interspecif variat ecolog behavior well intraspecif variat captiv wild specimen compar trunk vertebra bone microstructur captiv wild xenarthran mammal test effect ecolog captiv collect ct scan last six presacr vertebra fossori terrestri suspensori xenarthran speci bodi mass g kg vertebra measur centrum length bone volum fraction bvtv trabecular number mean thick tbth global compact gc cross section area mean intercept length star length distribut connect connect densiti wild specimen robust trabecula vari speci ecolog patholog wild specimen fossori taxa dasypus robust trabecula captiv clear differ bone microstructur wild captiv specimen suspensori taxa bradypus choloepus suggest locomotor ecolog influenc degre captiv affect bone microstructur captiv tamandua myrmecophaga higher bvtv tbth gc wild counterpart due captiv caus bone patholog result add understand variat mammalian bone microstructur suggest caution includ captiv specimen bone microstructur research indic need better replic habitat diet behavior anim captiv | D001842;D013131 | T023;T024 |
34,677,909 | impact mobil devic cancer diagnosi cytolog digit patholog widen pathologist opportun examin surgic cytolog sampl recent portabl mobil devic like tablet smartphon test applic digit technolog includ static dynam recent whole slide imag studi aim review publish literatur impact mobil devic cancer diagnos cytolog analysi focus diagnost potenti technic detail critic issu pitfal econom aspect | D034201;D009369 | T191;T073 |
34,677,905 | bifunct ionic coval organ network enhanc simultan remov chromium vi arsenic v oxoanion via synerget ion exchang redox process chromium vi arsenic v oxoanion major toxic heavi metal pollut water threaten human health environment safeti herein develop report bifunct ionic coval organ network icon integr guanidinium phenol unit simultan sequest chromat arsenat water via synergist ion exchang redox process guanidinium group facilit ion exchang base adsorpt chromat arsenat neutral ph fast kinet high uptak capac wherea integr phenol motif mediat cr vi cr iii redox process immobil chromat promot adsorpt arsenat via format cr iii v clustercomplex synergist ion exchang redox approach push high adsorpt effici chromat arsenat also uphold balanc cras uptak ratio regardless chang concentr presenc interf oxoanion | D001151;D014874 | T131;T121;T196 |
34,677,903 | restor experi polymetal nodul area deep seab polymetal nodul mine multipl advers effect benthic communiti perman loss habitat remov nodul habitat modif sediment one tool manag biodivers risk mitig hierarchi includ avoid minim impact rehabilit andor restor offset initi long term restor experi site polymetal nodul explor contract area clarion clipperton zone clear nodul preprototyp mine vehicl ii disturb dredg sledg iii undisturb iv natur devoid nodul accommod habitat loss deploy artifici ceram nodul studi possibl effect substrat provis recoveri biota impact sediment biogeochemistri seventi five nodul recov eight week colon sessil epifauna nodul remain seafloor sever year recoveri furthermor account habitat modif top sediment layer sediment epibenth sledg track loosen metal rake test feasibl sediment decompact facilit soft sediment recoveri analys granulometri nutrient one month sediment decompact reveal sand fraction proport lower within decompact sampl wherea total organ carbon valu higher consid slow natur recoveri rate deep sea communiti experi repres begin year studi expect gain insight natur time develop hard substrat communiti influenc nodul recoveri disturb sediment communiti result help us understand advers long term effect nodul remov provid evid base set criteria definit serious harm environ furthermor accompani research need defin robust ecosystem baselin order effect identifi restor success integr environ assess manag author integr environment assess manag publish wiley period llc behalf societi environment toxicolog chemistri setac | D044822;D017753 | T080;T070;T082 |
34,677,900 | quantit trait variant gabra under increas methamphetamin stimul sensit psychostimul methamphetamin cocain use disord genet compon remain most unknown conduct genom wide quantit trait locus qtl analysi methamphetamin stimul sensit facilit gene identif employ reduc complex cross close relat cbl mous substrain examin maximum speed distanc travel min follow methamphetamin mgkg ip maximum methamphetamin induc speed follow second third administr identifi singl genom wide signific qtl chromosom peak near cyfip locus lod peak cm mb methamphetamin induc distanc travel follow first second administr identifi genom wide signific qtl chromosom peak near function intron indel gabra code alpha subunit gaba receptor lod peak cm mb striatal cis express qtl map corrobor gabra function candid gene under methamphetamin induc distanc travel crisprca mediat correct mutant intron delet cblj background wild type cblnj allel suffici reduc methamphetamin induc locomotor activ toward wild type cblnj like level thus valid quantit trait variant qtv studi show power effici reduc complex cross identifi causal variant under complex trait function restor gabra express decreas methamphetamin stimul sensit support preclin human genet studi implic gaba receptor psychostimul addict relev trait import find major implic studi psychostimul cblj strain gold standard strain biomed research | D040641 | T028 |
34,677,899 | agreement controversi nation guidelin bronchiol result italian survey signific variat manag bronchiol often record parallel recommend univoc clinic approach challeng still question studi aim evalu diagnost therapeut manag bronchiol children adopt italian pediatrician follow nation guidelin | D001988 | T047 |
34,677,898 | smart nanogatekeep tumor theranost nanoparticul drug deliveri system nano ddss requir reliabl arriv persist resid tumor site minim target side effect clinic theranost howev due complic environ high interstiti pressur tumor tissu return bloodstream caus secondari side effect normal organ recent number nanogatekeep engin via structur transformablest strategi overcom undesir dilemma emerg structur transform nanogatekeep tumor imag therapi first overview particular nanogatekeep undergo structur transform tumor microenviron cell membran organell thereaft intellig structur stabl nanogatekeep revers activ artifici individu receptor overview final ongo challeng prospect nanogatekeep clinic translat briefli discuss | D009369;D057285 | T091;T191;T061 |
34,677,897 | preval frailti mobil disabl older peopl live retir villag determin preval rate frail prefrail robust mobil disabl older adult live retir villag within region victoria australia | D000073496 | T033;T046;T184 |
34,677,889 | coronavirus diseas covid vaccin recommend special popul patient exist comorbid vaccin sever acut respiratori syndrom coronavirus sar cov crucial step end current worldwid pandem howev sever particular vulner group popul includ suffici number coronavirus diseas covid vaccin trial therefor scienc advanc advic vaccin special popul covid continu evolv focus review provid latest recommend consider special popul ie patient rheumatolog autoimmun disord cancer transplant recipi chronic liver diseas end stage renal diseas neurolog disord psychiatr disord diabet mellitus obes cardiovascular diseas chronic obstruct pulmonari diseas human immunodefici virus current smoker pregnant breastfeed women elder children patient allerg reaction use current avail research evid | D000086382 | T047;T067 |
34,677,886 | part per million level catalyt annul asymmetr synthesi methanobenzo annulen alkyl lawson select react alkyl nitroethylen part per million ppm quinin nh thiourea catalysi furnish chiral methanobenzo annulen ee dr ton tandem michaelhenri annul asymmetr ppm level catalyt tandem annul would high inspir design mani ppm level organocatalyt reaction time final molecul basic skeleton antibiot | D013890 | T130;T109 |
34,677,885 | weigh environment impact recent investig detect fipronil imidacloprid contamin waterway sourc still definit determin fact activ substanc found caus concern impact discuss appropri parasiticid use | D007306 | T131 |
34,677,884 | import problem covid pandem may reduc number peopl travel abroad pet soar number dog import oversea mean ask anim come increas import part respons parasit control | D000086382;D004283 | T047;T067 |
34,677,883 | decis make absenc data parasiticid use companion anim generat much debat recent evid lack inform decis make mani vet face dilemma come balanc need client patient concern resist environment harm | D003657;D018634 | T097;T041 |
34,677,882 | inform educ owner engag owner convers parasiticid crucial ensur appropri use help involv understand client specif motiv concern | D003142 | T097;T080;T170;T054 |
34,677,880 | two big question vet veterinari nurs research weigh two key question surround appropri parasiticid use pet | D017750;D018634 | T097 |
34,677,878 | congenit x link neutropenia myelodysplasia somat tetraploidi due germlin mutat sept septin play key role mammalian cell divis cytokinesi previous implic germlin human disord male infant sever neutropenia progress dysmyelopoiesi tetraploid myeloid precursor identifi known genet etiolog neutropenia bone marrow failur found howev next generat sequenc germlin sampl patient reveal novel de novo germlin stop loss mutat x link gene sept result reduc sept stain bone marrow granulocyt precursor megakaryocyt patient skin fibroblast deriv induc pluripot stem cell ipsc produc reduc myeloid coloni particular granulocyt lineag crisprca knock patient mutat complet knock sept toler non patient deriv ipsc human myeloid cell line sept knock success erythroid cell line result clone reveal propens multinucl silico analysi predict mutat protein hinder dimer sept coil coil parallel antiparallel arrang could turn impair filament format data demonstr critic role sept chromosom segreg myeloid progenitor account unusu predisposit aneuploidi dysmyelopoiesi | D018095 | T045 |
34,677,872 | covid coagulopathi human blood protein mimic sar cov virus vaccin protein bacteri co infect induc autoimmun combin bacteria sar cov synerg induc autoantibodi target cardiolipin cardiolipin bind protein platelet factor prothrombin coagul factor sever covid often accompani coagulopathi thrombocytopenia abnorm clot rare complic follow sar cov vaccin caus coagulopathi unknown hypothes coagulopathi accompani sar cov infect vaccin result bacteri co infect synerg virus induc autoimmun due antigen mimicri blood protein bacteri viral antigen coagulopathi occur main sever covid character bacteri co infect streptococci staphylococci klebsiella escherichia coli acinetobact baumannii bacteria express unusu larg number antigen mimick human blood antigen sar cov adenovirus bacteria mimic cardiolipin prothrombin albumin platelet factor pf sar cov mimic complement factor rh antigen platelet phosphodiesteras factor ix x von willebrand factor vwf vwf proteas adamt adenovirus mimic prothrombin platelet factor bacteri prophylaxi avoid vaccin bacteri infect individu antigen delet vaccin may reduc coagulopathi risk also see video abstract https youtubezwdosghrpg | D000086382;D060085 | T047;T067 |
34,677,870 | effect mussel inspir co deposit hydroxymethyl methacryl poli methoxyethyl acryl hydrophil bind tendenc common hemodialysi membran molecular dynam simul molecular dock studi despit advanc field hemoincompat remain critic issu hemodialysi hd interact various human blood constitu polymer structur hd membran result complic activ immun system cascad ad hydrophil polym structur membran one modif approach decreas extent protein adsorpt studi conduct molecular dynam md simul understand interact three human serum protein fibrinogen fb human serum albumin transferrin common hd membran untreat modifi form poli aryl ether sulfon pae cellulos triacet use common dialyz polym membran modif perform hydroxymethyl methacryl hema poli methoxyethyl acryl pmea use polydopamin assist co deposit md simul use framework bind energi simul molecular dock simul also perform conduct molecular level investig two modifi polym hema pmea fb three protein act differ membran due uniqu natur surfac chemistri simul show pmea bind less intens fb higher number hydrogen bond reflect pmea superior perform compar hema simul suggest pae membran could use modifi form blood contact applic reflect lowest bind energi blood protein | D062105;D056004 | T044;T170;T066;T063 |
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