PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,677,012 | prepar liquid crystal base molecular imprint monolith molecular recognit thermodynam molecular imprint polym mip incorpor liquid crystallin monom imprint recogn templat low level crosslink thus address challeng associ convent mip embed imprint site low bind capac slow mass transfer due high degre crosslink compar tradit mip prepar mip greater number easili bind site effect overcom embed low util imprint site simultan decreas level chemic crosslink mass transfer templat molecul signific improv howev imprint effect liquid crystallin mip general weaker tradit mip due low degre crosslink therefor obtain liquid crystallin mip good imprint effect seri low crosslink liquid crystallin molecular imprint monolith prepar graft polymer evalu high perform liquid chromatographi hplc systemat determin relat polymer paramet affin result liquid crystallin mip experi trimethylolpropan trimethacryl trim use synthes monolith column skeleton toluen dodecyl alcohol porogen naproxen use templat liquid crystallin monom cyanophenyl cyclohexyl ethylen cpce ad graft synthes liquid crystallin mip monolith influenc acetonitril content ph mobil phase chromatograph retent templat molecul investig result show main forc mip recogn naproxen chang hydrogen bond hydrophob interact addit liquid crystallin monom frontal analysi adsorpt isotherm fit includ langmuir freundlich scatchard fit show crosslink degre liquid crystallin mip exhibit highest imprint factor heterogen specif adsorpt stronger non specif adsorpt analyz stoichiometr displac model total affin mip monolith templat molecul ln determin signific higher analogu indic liquid crystallin imprint monolith higher total affin templat molecul spatial match degre n templat molecul caviti structur mip also high inferior ketoprofen nevertheless ln valu ketoprofen indic spatial effect key factor determin recognit abil liquid crystallin imprint system analysi separ thermodynam reveal separ liquid crystallin mip entropi control process convent liquid crystallin free mip enthalpi control process base result addit liquid crystallin monom may alter recognit mechan mip appropri low crosslink degre signific improv recognit perform liquid crystallin mip pave way new generat mip | D050866;D054802 | T104;T063;T073 |
34,677,011 | research progress applic extern field separ technolog microfluid technolog separ micronanoscal micronanoscal concern interact entiti size rang biolog cell protein particl separ micronanoscal immens signific drug develop earli stage cancer detect custom precis therapi exampl recent year rapid advanc field cell therapi necessit develop simpl effect cell separ techniqu isol techniqu allow collect requir stem cell complex sampl develop materi scienc precis medicin separ particl also critic key physicochem properti micronanoscal high depend specif size shape function group mobil base charg characterist control perform separ system current demand made simultan innov separ system line detect platform imper accord various analyt method involv use extern forc flow field magnet field electr field acoust field use micronanoscal separ base physic chemic paramet separ materi analyt method select differ extern forc field micronanoscal separ enabl real time accur effici select separ howev present appli field separ technolog requir complex equip larg sampl amount make crucial miniatur integr separ technolog low cost rapid accur micronanoscal separ microfluid technolog repres micronanoscal separ technolog requir small volum liquid make cost effect high throughput enabl continu separ analysi fast respons microchip allow mani reaction final miniatur devic allow coupl multipl detector microchip continu growth progress microfluid technolog microfluid platform abl achiev non destruct separ cell also enabl line detect offer high separ effici allow rapid separ differ biolog sampl review primarili summar recent advanc microfluid chip base flow field electr field magnet field acoust field field separ technolog improv micronanoscal separ effici review also discuss various extern forc field micronanoscal microparticl singl cell separ substanc classifi introduct summar advantag disadvantag applic develop final prospect combin applic extern field separ technolog microfluid technolog earli screen cancer cell precis micronanoscal separ discuss advantag potenti applic combin technolog propos | D044085;D013672 | T090 |
34,677,010 | determin two quaternari ammonium salt disinfector portabl capillari electrophoresi devic base smartphon exist miniatur capillari electrophoresi ce devic use tablet comput data process analysi hinder portabl order solv problem smartphon base ce devic propos allow real portabl quantit analysi devic integr function capacit coupl contactless conduct detect c bluetooth communic furthermor kotlin languag base applic user friend interfac develop applic could control electrophoresi run ce devic also receiv data c detector real time display electrophoretogram process data peak area could calcul automat smartphon migrat time could obtain size develop devic cm cm cm weight kg quaternari ammonium salt qas disinfector dodecyl dimethyl benzyl ammonium bromid ddbab dodecyl trimethyl ammonium bromid dtab use analyt verifi perform develop devic experiment data show linear rang ddbab dtab moll respect correl coeffici r ddbab dtab respect indic good linear peak area concentr limit detect lod ddbab dtab moll respect intra day relat standard deviat rsds n ddbab dtab respect reveal good repeat addit mixtur ddbab dtab test two qas separ within min show good select final qas bromo geramin disinfector use field test valid perform design devic recoveri ddbab dtab respect indic good accuraci develop devic advantag good linear low lod good repeat high accuraci real portabl use quantit detect qas disinfector | D012492;D000068997 | T104;T073 |
34,677,008 | low lipoprotein level predict hepat fibrosi patient nonalcohol fatti liver diseas dyslipidemia cardiovascular complic comorbid nonalcohol fatti liver diseas nafld rang simpl steatosi nonalcohol steatohepat fibrosi cirrhosi hepatocellular carcinoma lipoprotein lp associ cardiovascular risk metabol abnorm impact sever liver damag patient nafld remain clarifi circul lp level assess patient biopsi proven nafld associ lp liver damag explor categor serum lp quartil receiv oper characterist curv use analyz accuraci serum lp hepat fibrosi predict hepat express lipoprotein lpa gene involv lipid metabol fibrogen process evalu rna sequenc subset patient nafld lp dosag avail n patient nafld elev lp level modest associ circul lipid carotid plaqu hypertens p convers patient low serum lp display insulin resist p transaminas elev p increas risk develop sever fibrosi p cirrhosi p addit diagnost accuraci lp predict fibrosi increas combin transaminas area curv fibrosi stage p hepat lpa express reflect serum lp level p reduc progress nafld p hepat lpa messeng rna level correl gene involv lipoprotein releas lipid synthesi fibrogenesi p final transmembran superfamili member tmsf rs apolipoprotein e apo rs proprotein convertas subtilisinkexin type pcsk rs known variant modul circul lipid may influenc serum lp level p conclus circul lp combin transaminas may repres novel noninvas biomark predict advanc fibrosi patient nafld | D065626 | T047 |
34,677,007 | lie face electromyographi approach studi decept behavior decept present walk life social interact matter homeland secur nevertheless reliabl indic decept behavior real life scenario remain elus | D008192;D007206 | T054;T055 |
34,677,006 | liver diseas risk hepatocellular carcinoma children mutat taldo mutat transaldolas taldo gene describ limit number case sever organ affect clinic manifest variabl often includ liver dysfunct andor hepatosplenomegali report patient present liver diseas earli onset hepatocellular carcinoma hcc patient cholestasi mutat taldo identifi next generat sequenc clinic laboratori histolog data collect four male patient identifi variant predict damag taldo three patient homozyg two protein truncatingon missens mutat one compound heterozyg two missens mutat median age present month rang day jaundic hepatosplenomegali pancytopaenia diagnosi corrobor detect minim transaldolas enzym activ skin fibroblast two case rais urin polyol third three patient underw liver transplant lt confirm hcc explant liver one patient sudden die short lt nontranspl case chronic liver diseas multipl dysplast liver nodul normal liver biochemistri alpha fetoprotein median follow year rang conclus transaldolas defici includ earli onset normal gamma glutamyltransferas liver diseas multisystem involv variabl progress patient diseas risk earli onset hcc may requir earli lt | D002239;D006528;D008113;D014153 | T191;T047;T116;T126 |
34,677,005 | effect inform motiv model domest brush hypochlorit base formula peri implant mucos random clinic studi manag mucos essenti long term mainten dental implant studi determin efficaci term clinic paramet adjunct domiciliari agent pair non surgic periodont therapi nspt patient peri implant mucos | D015921;D006997;D052016;D057873 | T047;T046;T074;T196;T197 |
34,677,004 | traf nck interact kinas critic regul procollagen traffick hepat fibrogenesi mice hepat fibrosi driven deposit matrix protein follow liver injuri hepat stellat cell hscs drive fibrogenesi produc matrix protein includ procollagen matur collagen follow secret disrupt intracellular procollagen process traffick caus endoplasm reticulum stress stress induc hsc apoptosi thus attract antifibrot strategi design immunofluoresc base small interf rna sirna screen identifi procollagen traffick regul hypothes protein could serv antifibrot target target sirna screen perform use immunofluoresc detect chang intracellular procollagen tumor necrosi factor receptor associ factor noncatalyt region tyrosin kinas interact kinas tnik identifi interrog vitro vivo use tnik kinas inhibitor ncb rna interfer mediat knockdown sirna screen identifi nine gene whose knockdown promot procollagen retent includ serinethreonin kinas tnik genet delet pharmacolog inhibit tnik small molecul inhibitor ncb disrupt procollagen traffick secret without impact procollagen express investig role tnik liver fibrogenesi analyz human murin liver find elev tnik express human cirrhot liver increas tnik express kinas activ fibrot mous liver activ primari human hscs final test whether inhibit tnik kinas activ could limit fibrogenesi vivo mice receiv ncb display reduc ccl induc fibrogenesi compar ccl alon although smooth muscl actin level unalt conclus sirna screen effect identifi tnik key kinas involv procollagen traffick vitro hepat fibrogenesi vivo | D011347;D017346 | T116;T126;T123 |
34,677,003 | transcrani magnet stimul modal psychiatr disord public trend transcrani magnet stimul tms noninvas brain stimul techniqu show potenti treat psychiatr disord although sever studi sought investig new tms modal treatment various psychiatr disord studi yet examin public trend research tms modal psychiatr disord studi investig public trend tms research psychiatr disord includ addict dementia major depress disord mdd obsess compuls disord ocd schizophrenia well tms modal includ bilater stimul deep tms high frequenc stimul low frequenc stimul theta burst stimul | D003865;D009771;D012559 | T048 |
34,677,002 | hla variant hla detect taiwanes individu one nucleotid substitut codon hla result novel allel hla | D015234 | T129 |
34,676,998 | high accur filter flag frequent hitter alphascreen assay suggest mechan alphascreen one wide use assay technolog drug discoveri due versatil dynam rang sensit howev presenc fals posit frequent hitter contribut difficulti interpret measur hts data although filter exist identifi frequent hitter alphascreen frequent base privileg scaffold develop filter time consum requir deep domain knowledg recent machin learn artifici intellig method emerg import tool advanc drug discoveri chemoinformat includ applic identif frequent hitter screen assay howev relat perform complementar machin learn scaffold base techniqu yet comprehens compar studi analys filter base privileg scaffold filter built use machin learn result demonstr machin learn method provid accur filter identif frequent hitter alphascreen assay scaffold base method easili redevelop new data measur present high accur model identifi frequent hitter alphascreen assay | D057166;D054852 | T170;T059 |
34,676,995 | development chang within extend face process network cross section function magnet reson imag studi field face process call core network intens research neural activ reliabl detect children adult use function magnet reson imag fmri howev core network counterpart call extend network less research present studi compar children adult brain activ extend system particular amygdala insula inferior frontal gyrus ifg use fmri compar brain activ pattern children age year adult emot face process task one hand children show increas activ extend face process system relat adult particular left amygdala right insula left ifg hand later indic reveal leftward bias children ifg compar adult result suggest brain activ associ face process character development decreas activ show develop associ rightward migrat face relat ifg activ possibl due competit neural space sever develop brain function development competit hypothesi | D000066499 | T041 |
34,676,994 | assess impact magnet reson treatment simul mrsim target volum delin dose organ risk oropharyng radiotherapi assess use radiat therapi rt plan mri perform treatment posit pmri target volum delin effect organ risk dose oropharyng cancer patient plan diagnost mri dmri ct scan | D058958;D011880 | T029;T061 |
34,676,991 | trend patient report outcom use earli phase dose find oncolog trial analysi clinicaltrialsgov patient report advers event ae may use adjunct clinician assess ae assess toler earli phase dose find oncolog trial dfot review dfot clinicaltrialsgov describ trend patient report outcom pro use | D000071066 | T170 |
34,676,989 | longitudin associ earli child weight gain parent feed child self regul later child bodi mass index longitudin studi examin associ child weight trajectori matern demanding respons feed child self regul | D016487;D000068356 | T054;T055 |
34,676,986 | rapid prepar antimicrobi activ polyurea coat dope nano zno recent covid virus led rise interest antimicrobi antivir coat frequent touch surfac public healthcar set coat may abil kill varieti microorgan bio structur reduc risk virus transmiss paper propos extrem rapid method introduc rare earth dope nano zno polyamin prepar anti microbi polyurea coat nano zno prepar wet chemic method dope nano zno obtain mix nano zno dopant appropri amount nitric acid rapid fabric polyurea coat effect reduc bacteria enrich surfac compar pure nano zno group polyurea coat four differ rare earth element la ce pr gd dope nano zno la dope nano zno formula group indic highest bactericid rate escherichia coli e coli pseudomona aeruginosa pseudomona follow cezno bactericid rate may still remain high room temperatur min uv exposur believ dope process may great improv photocatalyt respons uv light well environment temperatur due thermal catalyt enhanc surfac character bioassay coat durabl high bactericid rate even repeat usag polyurea coat high mechan strength adhes forc substrat materi without peel found rapid prepar method also provid good prospect practic applic | D000890;D000086382;D015034 | T047;T121;T197;T067 |
34,676,985 | use autoinfl devic lead clinic meaning chang hear threshold children otiti media effus object studi establish whether autoinfl effect intervent paediatr audiolog servic pragmat retrospect studi histor control use pair avail design | D006309 | T039 |
34,676,984 | yeast metabol innov emerg via expand metabol network gene posit select yeast known versatil metabol trait metabol trait evolv elucid systemat perform integr evolut analysi investig genom evolut determin trait generat reconstruct genom scale metabol model gem yeast gem could comprehens character trait divers predict enzym function therebi signifi sequenc level evolut shape reaction network toward new metabol function strike use gem mechanist map differ evolutionari event eg horizont gene transfer gene duplic onto relev subpathway explain metabol plastic demonstr gene famili expans enzym promiscu promin mechan metabol trait gain gem simul reveal addit factor gene loss distant pathway contribut trait loss furthermor analysi could pinpoint specif gene pathway posit select relev formul complex metabol trait ie thermotoler crabtre effect find illustr multidimension evolut metabol network structur individu enzym drive phenotyp variat | D053858;D012441 | T044;T169;T004 |
34,676,983 | machin learn predict drug target microb associ cardiovascular diseas incorpor host pathogen interact network paramet host pathogen interact play crucial role invas infect induct immun respons human work four machin learn algorithm name logist regress k nearest neighbor support vector machin random forest implement classif drug target algorithm train use host pathogen drug non drug target protein learn instanc protein pathogen host featur comput includ sequenc structur biolog host pathogen network central characterist random forest classifi model achiev best accuraci fold cross valid accuraci achiev roc auc score pathogen host train set eigenvector central host pathogen interact host host interact top featur perform classif pathogen host target respect featur import classif presenc catalyt bind site low instabilityaliphat index cellular locat random forest classifi use predict drug target involv microb associ cardiovascular diseas host pathogen protein predict drug target random forest model valid experiment therapeut intervent microb associ cardiovascular diseas | D002318 | T047 |
34,676,978 | graphen confer ultralow friction nanogear cog friction induc energi dissip imped perform nanomechan devic nevertheless applic graphen known modul friction dissip induc local strain work report nanomechan graphen conform differ textur silicon surfac mimic cog nanoscal gear variat pitch length regul strain induc cap graphen reveal scan probe techniqu raman spectroscopi molecular dynam simul atomist visual elucid asymmetr strain cc bond corrug architectur result distinct friction dissip respect groov axi experiment result report strain depend solid lubric regul corrug lead ultralow friction forc result applic graphen cover corrug structur movabl compon nanoelectromechan system nanoscal gear robot | D006108 | T196;T109 |
34,676,977 | decad synthesi atmospher emiss ambient air qualiti deposit oil sand region review part seri synthes peer review literatur past decad environment monitor oil sand region osr northeastern alberta focus atmospher emiss air qualiti deposit downwind osr publish monitor research activ concentr surfac mineabl region athabasca osr substanti progress made understand oil sand os relat emiss sourc use multipl approach airborn measur satellit measur sourc emiss test determinist model sourc apportion model approach general yield consist result indic os relat sourc region contributor near air pollut pollut exhibit enhanc air concentr within km surfac mine activ enhanc km downwind pollut eg sulfur dioxid nitrogen oxid undergo transform transport atmospher deposit rate os relat substanc primarili emit fugit dust enhanc within km surfac mine activ wherea gaseous fine particul emiss diffus deposit enhanc pattern extend hundr kilomet downwind general air qualiti guidelin exceed although singl pollut threshold comprehens indic air qualiti odor event occur communiti near os industri activ although difficult attribut event specif pollut sourc nitrogen sulfur polycycl aromat compound pac base cation os sourc occur environ explicit deleteri respons organ pollut appar across studi environ detail biolog monitor discuss paper special seri howev model critic load exceed suggest continu emiss level ecolog chang may occur futur knowledg gap recommend futur work address gap also present integr environ assess manag author integr environment assess manag publish wiley period llc behalf societi environment toxicolog chemistri setac | D000393;D000397 | T131;T069;T080 |
34,676,972 | inorgan phosphat induc cytotox phosphat essenti nutrient avail organ inorgan form balanc phosphat central cellular homeostasi genom role dna rna synthesi cell signal process therefor imbal nutrient manifest either defici excess phosphat level result patholog rang cytotox musculoskelet defect inorgan phosphat pi overdos result wide spectrum cytotox process note anim model human studi includ rewir cell signal pathway impair bone miner infertil prematur age vascular calcif renal dysfunct articl briefli review regul phosphat homeostasi elabor cytotox effect excess pi document cell base model | D002113;D010710 | T042;T197 |
34,676,971 | arsv arsw provid synergist resist antibiot methylarsenit toxic organoarsen enter environ biogen anthropogen activ microbi methyl inorgan arsenic pentaval herbicid monosodium methylarsen msma mas v trival mas iii consider toxic arsenit arsenat microb evolv mechan detoxifi organoarsen previous identifi arsv flavin link monooxygenas demonstr confer resist methylarsenit oxid methylarsen arsv gene usual arsenic resist ar operon control arsr repressor adjac methylarsenit efflux gene either arsk gene putat transport show paracoccus sp sy oxid methylarsenit ar operon three gene arsr arsv transport gene term arsw heterolog express arsv escherichia coli confer resist mas iii arsw co express arsv arsw increas resist compar either alon cell oxid methylarsenit accumul less methylarsen evert membran vesicl e coli cell express arsw accumul methylarsen propos arsv monooxygenas oxid methylarsenit methylarsen extrud arsw one known pentaval organoarsen efflux permeas novel pathway organoarsen resist | D001151;D001152 | T131;T121;T104;T196 |
34,676,970 | retrospect multicentr studi evalu periop outcom singl port robot cholecystectomi compar xi sp version da vinci robot surgic system singl incis robot cholecystectomi sirc wide perform da vinci xi system xi da vinci sp system sp limit number studi compar platform | D065287 | T061 |
34,676,969 | urinari dehydrothromboxan b aspirin efficaci test sensit periop inflamm pediatr solid organ transplant patient evid aspirin efficaci test pediatr limit especi outsid cardiolog yet thrombot event high morbid area pediatr transplant surgeri debat whether thromboembol event aspirin repres aspirin resist high treatment platelet reactiv persist given poor intertest agreement test platform | D016377;D010372;D013927 | T091;T046;T061 |
34,676,966 | overview approv procedur bioadhes unit state america canada bioadhes use medic devic help reduc postop complic adjunct sutur stapl seal wound biomed compani promot research develop new bioadhes medic devic translat promis candid market involv need pass sever regulatori step wherein safeti effect evalu proper reimburs payor assess regulatori procedur involv classif base risk factor support studi submiss applic relev author procur certif final commerci keep track record post market data import real world data recent realiz aim review focus translat goal expect necess medic devic focus bioadhes commerci aid research inspir discov market new bioadhes understand need basic regulatori procedur behind commerci medic usag import intern medicin specif unit state america canada europ part key differ regulatori aspect among highlight regul keep chang introduct new product government law updat manuscript till march | D004864;D058106 | T061;T074;T073 |
34,676,965 | expand clinicopatholog genet spectrum gne myopathi chines neuromuscular centr gne myopathi heterogen group ultrarar neuromuscular disord caus mutat gne gene estim preval lead defici data lack avail sampl conduct clinic research neuromuscular disord although gne mutat gene respons diseas well known key enzym biosynthesi pathway sialic acid clinicopatholog genet spectrum gne mutant patient still unclear expand studi present ten unrel patient gne myopathi discov five novel missens mutat clinic electrophysiolog imag patholog genet data present retrospect manner interest sever patient cohort found peripher neuropathi inflammatori cell infiltr muscl biopsi seldom report studi conduct neuromuscular centr china first attempt highlight abnorm clinicopatholog featur associ genet mutat gne myopathi | D020022;D009154;D010641 | T032;T045 |
34,676,963 | wake call older hospitalis patient nocturn lower urinari tract symptom nocturn lower urinari tract symptom nlut increas age frailti comorbid system ill affect mani older peopl aim studi describ preval nlut hospit age care sub acut environ | D059411;D053158;D053206 | T048;T047;T184 |
34,676,962 | comparison outcom surviv victoria denmark lung cancer surgeri opportun intern benchmark victoria australia denmark compar popul size high qualiti healthcar system lung cancer surgeri howev perform victorian hospit compar four denmark differ central may influenc outcom engag clinic qualiti registri enabl intern benchmark explor pattern lung cancer surgeri includ mortal surviv | D002289;D008175 | T191 |
34,676,961 | drain fluid amylas lipas predict factor postop pancreat fistula earli detect postop pancreat fistula popf may improv outcom pancreaticoduodenectomi pd aim assess role postop drain fluid amylas dfa lipas dfl measur predict indic develop popf | D008049;D010185 | T116;T047;T121;T126 |
34,676,959 | evalu ultrasound bladder scanner supin stand posit studi examin perform bladder volum measur devic bladderscan bs bvi use bs offer possibl assess bladder volum posit patient perform daili imag guid radiotherapi procedur patient often lie enter treatment vault therefor bs also assess stand posit | D061089;D001743 | T023;T061 |
34,676,958 | mobil aid predict mortal transcathet aortic valv implant select appropri patient transcathet aortic valv implant tavi challeng mani factor influenc post procedur outcom tradit surgic score system discrimin effect medic paramet function indic character mortal risk mobil import predict function index larg defin use subject criteria | D001024;D065467 | T047;T061 |
34,676,954 | ethnic region differ tempor trend prostat cancer incid mortal new zealand prostat cancer pca frequent diagnos cancer new zealand nz men third lead caus cancer death tempor chang pca incid mortal report despit chang pca landscap studi aim analys tempor trend pca focus ethnic region variat | D005006;D011471 | T191;T098;T102 |
34,676,953 | predict factor bleed carotid arteri pseudoaneurysm patient previous radiat head neck cancer bleed carotid arteri pseudoaneurysm emerg condit high morbid mortal aim identifi risk factor predict pseudoaneurysm bleed caus profus epistaxi irradi head neck cancer patient suspect carotid blowout pseudoaneurysm | D017541;D006258 | T191;T046 |
34,676,952 | prolifer cell nuclear antigen present marker folliculogenesi transplant ovarian tissu one import way understand ovarian biolog stud initi primordi follicl develop subsequ folliculogenesi control studi prolifer cell nuclear antigen pcna present use marker follicular develop thaw ovarian tissu ot follow transplant onto chick embryo chorioallanto membran cam use two method freez slow freez vitrif | D010053;D058989 | T070;T023 |
34,676,951 | toward conceptu converg systemat review psycholog resili famili caregiv person live chronic neurolog condit demand famili caregiv person chronic neurolog condit cncs increas psycholog resili may empow protect caregiv role thus synthesi resili evid within specif popul warrant | D017028;D055500 | T097;T055;T098;T099 |
34,676,950 | doubl immun reconstitut therapi cladribin alemtuzumab treatment multipl sclerosi alemtuzumab monoclon anti cd antibodi cladribin purin nucleosid analogu use treatment high activ relaps remit multipl sclerosi ms administ two short year cours possess abil induc long term remiss label immun reconstitut therapi although diseas activ alemtuzumab administr rare small number peopl ms experi diseas activ despit repeat alemtuzumab treatment | D000074243;D009103;D020529 | T040;T047 |
34,676,949 | associ increas level omentin carotid intima media thick earli sign cardiovascular risk patient polycyst ovari syndrom prospect case control studi omentin adipokin primarili secret viscer adipos tissu regul metabol homeostasi wherea carotid intima media thick cimt valid marker earli diagnosi atherosclerosi aim investig whether polycyst ovari syndrom pcos relat level omentin cimt demonstr associ cardiovascular risk | D002318;D011085 | T047 |
34,676,948 | util lena indic development outcom young children autism grow understand potenti benefit multi method approach accur captur languag skill children autism spectrum tool languag environ analysi lena provid effici mean captur analys earli child vocal cvs languag learn environ develop captur whole day record child languag naturalist set potenti util captur littl knowledg primari lena metric includ cvs convers turn cts novel metric vocal ratio vrs sampl clinic practic set children often seen moreov recent research indic novel vr may offer broad indic children development level beyond languag abil hypothesi yet investig larg sampl children lena design ie pre schooler | D000067877;D001321;D007805 | T033;T048;T047 |
34,676,946 | safeti durabl cavo tricuspid isthmus linear ablat current era singl center year experi procedur cavo tricuspid isthmus cti linear ablat perform atrial flutter afl empir atrial fibril af ablat real world practic purpos sought evalu safeti durabl cti ablat method retrospect studi includ consecut patient underw cti ablat afl document procedur patient empir cti af ablat perform patient result cti block success creat patient min total radiofrequ time repeat procedur perform recurr arrhythmia patient median month postprocedur conduct resumpt identifi among undergo cti ablat af ablat durabl signific higher without document afl vs p total radiofrequ time signific shorter vs min p durabl signific higher vs p larg tip irrig tip cathet group iatrogen afl observ empir cti ablat patient procedur relat complic occur patient eight patient experienc coronari arteri spasm includ one ventricular fibril follow st elev ward six patient experienc transient atrioventricular block one experienc cardiac tamponad requir drainag conclus despit high acut cti ablat success conduct block durabl relat low empir ablat empir cti ablat time af ablat recommend | D001281;D001282;D017115 | T047;T061;T046 |
34,676,944 | antenn sensilla anophthalm wood dwell speci clinidium canaliculatum costa coleoptera rhysodida habit feed slime mould myxomycet common present litter dead wood requir specif morpholog adapt mouthpart sensori structur involv search habitat food studi extern morpholog antenna sensilla studi use scan electron microscopi saproxyl beetl clinidium canaliculatum costa coleoptera rhysodida moniliform antenna consist scape pedicel nine flagellomer identifi seven differ type sensilla accord morpholog characterist two type sensilla chaetica sc two type sensilla basiconica sb one type sensilla campaniformia one type sensilla coeloconica bhm sensilla sexual dimorph found regard antenn morpholog sensilla type distribut except sensilla coeloconica function role sensilla discuss relat extern structur distribut compar current knowledg coleopteran sens organ result basic inform physiolog behavior studi identifi role select habitat food mate oviposit site | D001517;D058618 | T204;T023 |
34,676,943 | trend hospitalis common paediatr infect australian experi respiratori tract infect rtis acut gastroenter age signific impact health servic use among children howev recent trend hospit admiss rate well document object describ admiss rate rti age among children one jurisdict year period associ length stay los monetari cost chronic condit | D005759;D006760 | T058;T047 |
34,676,942 | parent socioeconom status asthma children use popul base cohort famili design observ associ parent socioeconom status ses measur educationincom asthma wheez offspr may explain confound unmeasur factor share gene famili environ aim studi associ parent ses asthmawheez use cousin comparison | D001249;D012135 | T033;T047;T184;T201 |
34,676,941 | genet structur protist physarum albescen amoebozoa reveal multipl marker genotyp sequenc myxomycet terrestri protist mani presum cosmopolitan speci dispers via airborn spore truli cosmopolitan speci would suffer outbreed depress hamper local adapt local adapt speci limit distribut would higher risk extinct chang environ investig intraspecif genet divers phylogeographi physarum albescen entir northern hemispher sequenc field collect fruit bodi genet marker ssu efa coi analys specimen genotyp sequenc structur three gene phylogeni snp base phylogeni phylogenet network observ recombin pattern three independ inherit gene marker best explain presenc least reproduct isol group seen cryptic speci intens sampl region mani local member sever phylogroup coexist phylogroup found abund one region complet absent well studi region thus may repres region endem result demonstr wide distribut myxomycet speci ph albescen repres complex least cryptic speci seem limit geograph distribut addit presenc group presum clonal specimen suggest sexual asexu reproduct coexist natur popul myxomycet | D056894;D010804 | T204 |
34,676,940 | effect regulatori intervent agomelatin use spain multipl intervent time seri analysi nationwid electron healthcar record databas liver injuri import identifi risk agomelatin sever measur put place prevent minim risk studi aim assess impact four intervent incid agomelatin use particular among patient age spain | D000081;D003695 | T058;T093;T109 |
34,676,939 | potenti new therapeut target alzheim diseas glucagon like peptid increas evid show close relationship alzheim diseas ad type diabet mellitus tdm recent glucagon like peptid glp gut incretin hormon becom well establish treatment tdm like involv treat cognit impair mini review similar ad tdm summaris main focus glp base therapeut ad | D000544;D060825;D003924 | T048;T047 |
34,676,938 | imag blood brain barrier permeabl mri pediatr sickl cell diseas feasibl studi blood brain barrier bbb disrupt may lead endothelium dysfunct inflamm sickl cell diseas scd howev abnorm bbb scd especi pediatr patient contrast agent administr less optim fulli character | D000755;D001812 | T023;T047 |
34,676,935 | popul genom olfactori dietari gut microbiota analys demonstr uniqu evolutionari trajectori feral pig domest intrigu evolutionari process mani domest popul subject strong human mediat select individu return wild subject select forc associ new environ general feral popul evolv someth differ wild predecessor member typic possess combin wild human select trait feralis manifest differ form spectrum wild domest phenotyp depend rewild domest popul readapt natur environ base much potenti flexibl ancestr genom retain domest signatur whether feralis lead evolut new trait exist wild converg wild form howev remain unclear address question perform popul genom olfactori dietari gut microbiota analys differ popul sus scrofa wild boar hybrid feral sever domest pig breed porcin singl nucleotid polymorph snps analysi show feral popul repres cluster distinct separ other member display signatur past artifici select demonstr valu f st specif region genom bottleneck signatur number length run homozygos generalis f st valu reacquir olfactori abil diet gut microbiota variat show current respons natur select result suggest feral pig independ evolutionari unit persist long level human intervent remain unchang | D000069196 | T007;T001 |
34,676,934 | partit macroscal microscal ecolog process use covari driven non stationari spatial model ecolog infer requir integr inform across scale integr creat complex spatial depend structur accur repres fulli non stationari model howev ecologist rare use model difficult estim interpret facilit use fulli non stationari model ecolog improv interpret recent develop non stationari model appli improv understand spatial process drive lake eutroph reformul model incorpor non stationari correl ad environment predictor covari function therebi build intuit mean regress creat ellips visual data given site correl surround ie rang direct under spatial process appli model describ spatial depend structur variabl relat lake eutroph across two differ region midwestern unit state region high agricultur landscap northeastern unit state region heterogen land use midwest increas forest cover increas homogen residu spatial structur total phosphorus indic macroscal process domin nutrient spatial structur convers high forest cover baseflow reduc spatial homogen chlorophyl residu indic microscal process domin chlorophyl midwest northeast increas urban land use baseflow decreas homogen phosphorus concentr indic domin microscal process none covari strong associ residu spatial structur chlorophyl model show spatial depend structur environment respons variabl shift across space also help explain structur use ecolog relev covari differ scale whose effect interpret intuit provid novel insight process lead eutroph complex pervas environment issu | D004784;D005068 | T057;T067 |
34,676,929 | catalyt atroposelect c functionalis indolin indol axial chiral atropisomer compound wide appli asymmetr catalysi medicin chemistri particular axial chiral indol indolin base framework recognis import heterobiaryl class core unit bioactiv natur alkaloid chiral ligand bioactiv compound among synthesi c substitut indol biaryl analog indolin deriv particular challeng method effici synthesi high demand transit metal catalysi consid one effici method construct atropisom report enantioselect synthesi c indolino c indolo biaryl atropisom mean c h functionalis catalys chiral rhjascp complex | D007211 | T109 |
34,676,924 | extracellular matrix synthet hydrogel base prostat cancer organoid regul therapeut respons ezh drd inhibitor follow treatment androgen receptor ar pathway inhibitor prostat cancer patient progress shed ar depend tumor undergo epigenet reprogram turn castrat resist prostat cancer adenocarcinoma crpc adeno neuroendocrin prostat cancer crpc nepc target therapi avail crpc nepc minim organoid model discov new therapeut target aggress tumor use combin patient tumor proteom rna sequenc spatial omic synthet hydrogel base organoid putat extracellular matrix ecm cue regul phenotyp transcriptom epigenet underpin crpc nepc defin short term cultur tumor express ecm differenti regul dna methyl mobil gene crpc nepc ecm type distinct regul respons small molecul inhibitor epigenet target dopamin receptor drd latter understudi target neuroendocrin tumor vivo patient deriv xenograft immunocompromis mice show strong anti tumor respons treat drd inhibitor final demonstr therapeut respons crpc nepc drug resist ecm condit overcom first cellular reprogram epigenet inhibitor follow drd treatment synthet organoid suggest regulatori role ecm therapeut respons target therapi crpc nepc enabl discoveri therapi overcom resist | D009940;D064129 | T191;T024 |
34,676,918 | efficaci calcium phosphatefluorid varnish ionomer sealant cervic dentin hypersensit random doubl blind placebo control clinic studi dentin hypersensit dh common problem popul signific impact qualiti life suffer condit | D057133;D003807 | T047;T121 |
34,676,917 | genom landscap circul tumour dna metastat extramammari paget diseas although cancer person profil deep sequenc capp seq cell free dna cfdna gain attent clinic util circul tumour dna ctdna extramammari paget diseas empd investig studi genom alter cfdna tumour tissu dna investig seven patient metastat empd capp seq reveal mutat gene yet report empd variant allel frequenc mutat gene reflect diseas cours patient empd one patient mutat detect even though imag find reveal metastasi anoth patient tripl empd genit area axilla cfdna sequenc detect mutat rib metastat lesion also detect axilla lesion genit region investig ctdna may use toward elucid clonal evolut empd | D000073888;D000074141;D010145;D012878 | T191;T114;T123 |
34,676,916 | influenc load protocol platform switch two implant bar retain overdentur year result random control equival clinic trial test null hypothesi vertic peri implant bone level alter ibl equival immedi il month post placement dl load implant mandibular implant overdentur iod two implant | D016301;D015921;D057893 | T074;T047;T061 |
34,676,912 | south african parkinson diseas studi collect parkinson diseas pd incid increas sub saharan africa recruit individu pd differ ancestr group across south africa afrikan european earli onset pd ancestr group men pd women younger age onset men year | D010300 | T047 |
34,676,910 | donor age sex limit effect mechan microstructur properti human connect tissu connect tissu tendon ligament capsul play larg role locomot joint stabil often subject traumat injuri degener purpos studi evalu mechan microstructur properti connect tissu correl age sex human donor dissect sampl prepar mechan test consist cycl precondit stress relax ramp hold quasi static ramp failur test protocol microstructur organ tissu analyz use quantit polar light imag linear mix model use assess whether tissu type donor age donor sex signific associ mechan microstructur tissu properti tissu type signific effect paramet donor age sex group tissu type ie tendon vs ligament vs capsul evid microstructur data tendon tighter group ligament larger spread valu interact tissu type age yield signific effect linear modulus p palmari tendon appear largest contribut effect signific interact effect sex tissu type donor age donor age appear affect linear modulus tissu type otherwis age sex signific effect mechan microstructur properti rang connect tissu analyz studi | D008022;D013710 | T023;T024 |
34,676,909 | map corticoreticular pathway cortex wide anterograd axon trace mous corticoreticular pathway crp implic import mediat motor recoveri rehabilit central nervous system damag howev origin trajectori later well understood studi map mous crp comparison corticospin tract cst systemat search allen mous brain connect atlas allen institut brain scienc experi use anterograd tracer inject right isocortex mice elig experi n crp cst project strength quantifi tracer volum reach reticular format motor nuclei rf motor pyramid respect tracer densiti brain voxel also correl rf motor versus pyramid project strength explor relat trajectori crp cst found signific crp project origin primari secondari motor cortic anterior cingul primari somatosensori cortex medial prefront cortex compar cst crp stronger project region except primari somatosensori cortex ipsilater project stronger contralater tract pyramid decuss crp project bilater cst estim crp trajectori anteromedi cst intern capsul dorsal cst brainstem find reveal widespread distribut crp origin confirm strong bilater crp project theoret increas potenti partial spare brain lesion contralesion compens unilater injuri | D009044;D011712 | T023;T029 |
34,676,908 | associ year sleep behaviour trajectori childhood adolesc myopia ocular biometri young adulthood cross section studi variabl report poor sleep qualiti may associ myopia children longitudin data collect age myopia develop progress could provid new insight sleep myopia paradigm studi test hypothesi year trajectori sleep behaviour childhood adolesc associ myopia young adulthood | D001699;D009216 | T062;T047 |
34,676,907 | famili base treatment adolesc anorexia nervosa outcom step care model step care model treatment underexplor eat disord enhanc treatment outcom inform literatur adapt famili base treatment fbt develop fbt base step care model adolesc anorexia nervosa consist famili prefer ie tailor respons adolesc need ie intens aim studi evalu effect model term remiss end treatment | D000856 | T048 |
34,676,902 | preval periap lesion root canal treatment restor teeth adjac implant tooth support crown multi centr cross section studi describ preval periap lesion root canal treatment coron restor teeth adjac either implant natur tooth support crown use cone beam comput tomographi cbct assess compar nonadjac teeth | D003786;D010485 | T047;T030 |
34,676,901 | banff consensus recommend steatosi assess donor liver consensus criteria approach exist regard assess steatosi set human donor liver suitabl transplant banff work group liver allograft patholog undertook studi determin consist steatosi assess report frozen section potenti donor liver | D005234;D016031 | T047;T061 |
34,676,899 | evid mixotrophi pico chlorophyt new picochlorum trebouxiophycea strain mixotroph increas recogn wide distribut aquat ecosystem signific contribut biogeochem cycl mani taxa within phyla chrysophyta cryptophyta haptophyta capabl phago mixotrophi howev phagotrophi chlorophyta remain controversi due insuffici research solid evid studi identifi new strain picochlorum sp glmf trebouxiophycea use rrna gene analysi morpholog observ display multi cell divis autosporul two four cell daughter two unequ flagella never report genus picochlorum use multipl method includ bioimag analysi acid food vacuol like compart stain prey reduct calcul discov confirm bacterivori picochlorum provid strong evid phago mixotrophi green alga addit found picochlorum sp glmf grow complet dark prey deplet condit suggest light bacteria indispens strain mixotroph nutrit mode oblig like phago phototroph picochlorum sp glmf capabl regul growth ingest rate accord light intens inorgan nutrient concentr confirm mixotrophi picochlorum strain advanc understand trophic role green alga well photosynthet picoeukaryot marin microbi food web | D000460;D044523;D058087 | T204;T002 |
34,676,898 | benefit give effect prosoci behavior recoveri stress individu regular face stress manner cope stress crucial compon predict stress recoveri mani engag self reward behavior feel better behavior come cost current studi test effect engag differ behavior experienc stress prosoci behavior given health benefit associ give other plausibl engag prosoci behavior success reduc psycholog physiolog respons stress test particip underw trier social stress test either sent gift card person choos receiv gift card select aesthet pleas gift card measur self report mood heart rate blood pressur salivari alpha amylas cortisol collect throughout session manipul elicit differ psycholog hormon measur give group show signific greater downregul heart rate diastol blood pressur mean arteri pressur recov stressor addit give group evidenc greater prosoci sentiment show larger reduct diastol blood pressur mean arteri pressur follow studi suggest behavior may engag differ reward compon gave gift card report greater like receiv gift card report greater want overal find show engag prosoci behavior follow stressor help downregul physiolog stress respons | D000533 | T054 |
34,676,897 | avoid cope mediat effect hardi mental distress symptom male femal subject person disposit hardi shown associ adapt cope strategi consid import protect factor develop mental health symptom one critic found hardi literatur concern question whether construct equal import men women use prospect design moder mediat model regress analys perform examin effect avoid cope associ hardi mental distress effect biolog sex examin associ hardi avoid cope sampl includ civilian personnel employ militari organ result show higher hardi level associ lower report use avoid cope turn associ lower level distress symptom avoid cope mediat effect hardi anxieti symptom indirect effect moder biolog sex result indic hardi oper similar women men factor influenc mental distress symptom | D001523;D008889;D055500 | T097;T048;T055 |
34,676,896 | adolesc satisfact care abort relat complic sub saharan african countri cross section facil base studi assess satisfact care abort relat complic experienc among adolesc compar older women | D000028;D000022 | T047;T046;T093;T061;T081;T033 |
34,676,895 | exploit virgin oliv oil product olea europaea l phenol volatil compound transform phenomena fresh two phase oliv pomac alperujo differ storag condit much effort recent spent use virgin oliv oil product nutraceut ingredi human diet thank rich bioactiv phenol manag easi produc aim provid use inform better manag fresh oliv pomac dri studi phenol volatil compound transform phenomena fresh oliv pomac store differ condit plan simul control uncontrol temperatur condit oliv oil mill | D031658;D055549 | T002;T168;T109 |
34,676,894 | pathway matern depress symptom children academ perform adolesc year prospect longitudin studi pathway exposur matern depress symptom earli childhood link academ perform adolesc poor understood studi test pathway matern depress symptom age adolesc academ perform age cumul parent risk age subsequ child function age use multi inform data prospect longitudin communiti studi span year n male white structur equat model test indirect effect reveal small associ matern depress symptom increas cumul parent risk poorer child function via pathway poorer academ perform thus childhood exposur matern depress symptom may associ pathway risk could limit children educ opportun | D000073978;D003863 | T080;T048;T184 |
34,676,893 | latent class aggress peer victim measur invari differenti item function across sex race ethnic cohort studi site peer victim common link maladjust prior research typic identifi four peer victim subgroup aggressor victim aggress victim uninvolv howev find relat sex racial ethnic differ subgroup membership mix use data collect septemb studi conduct confirmatori latent class analysi racial ethnic divers sampl sixth grader boy black hispan repres two cohort school four us communiti replic four subgroup evalu measur invari latent class indic across cohort sex race ethnic studi site result replic four class solut illustr sociodemograph differ subgroup membership less evid account differenti item function | D058445;D019548 | T048;T068;T098 |
34,676,892 | level determin contracept uptak among women attend facil abort relat complic east southern africa investig level determin nonreceipt contracept among women admit facil abort relat complic east southern africa | D000028;D003270 | T121;T039;T046;T093;T061;T081;T033 |
34,676,891 | domin clade featur sar cov co occur mutat reveal plausibl epistasi silico base hypothet model sever acut respiratori syndrom coronavirus sar cov evolv eight fundament clade four clade g gh gr gv global preval explain plausibl epistat effect signatur co occur mutat circul clade viral replic transmiss fit propos hypothet model use silico approach molecular dock dynam analys show higher infecti spike mutant favor bind g elastas rdrp mutat ppl signific increas genom wide mutat p allow flexibl rdrp mutat nsp interact may acceler replic superior rna stabil structur variat nsp ct might impact protein rna interact anoth silent utr ct mutat might affect translat effici viral packag four g clade featur co occur mutat might increas viral replic sentinel gh clade orfa pqh variant constrict ion channel intertransmembran domain interact cystein c histidin h gr clade n prg kr would stabil rna interact flexibl hypo phosphoryl sr rich region gv clade virus seem gain evolutionari advantag confound factor nevertheless n pav might modul rna bind phenotyp effect hypothet model need retrospect prospect studi understand detail molecular event relationship fit sar cov | D000086382;D000086402 | T047;T005;T067 |
34,676,890 | benchmark ab initio proton affin gas phase basic alanin base coupl cluster theori statist mechan determin proton affin pa gas phase basic gb amino acid alanin chemic accur level perform explicit correl ccsd fbaug cc pvdz geometri optim normal mode vibrat frequenc calcul well ccsd fbaug cc pvtz energi comput possibl neutral proton geometri temperatur effect k consid translat rotat vibrat enthalpi entropi correct obtain via standard statist mechan util molecular geometri harmon vibrat energi level amino nitrogen n carbonyl oxygen atom proven potenti proton site systemat conform search reveal n proton conform kcalmol energi rang k respect final comput pa gb valu k case n proton kcalmol respect wherea correspond valu proton kcalmol result benchmark high level coupl cluster comput util assess accuraci sever lower level cost effect method mp densiti function theori various function sogga x x pbe blyp tpss | D011522 | T196 |
34,676,889 | case seroneg autoimmun enceph associ human herpesvirus hhv last year increas number patient present acut enceph observ find attribut autoimmun mechan despit fact autoantibodi usual target neuron cell surfac synapt protein central nervous system cns mani case remain undetect constitut futur diagnost therapeut challeng human herpesvirus hhv proven neurotrop virus caus various neurolog complic most adult popul present case year old girl confirm activ hhv infect cns develop acut seroneg autoimmun enceph best knowledg literatur concern pediatr case autoimmun enceph follow hhv infect | D016199 | T005 |
34,676,888 | clozapin treatment risk sever covid infect investig whether patient clozapin treatment increas risk sever covid infect compar patient antipsychot drug | D000086382;D003024 | T047;T121;T109;T067 |
34,676,885 | assess concurr valid day aliv home metric patient live serious ill valu spend time home emerg data suggest day aliv home dah may use metric howev research need aim assess concurr valid dah respect clinic signific chang patient caregiv report outcom pros | D006699;D010166 | T058;T061 |
34,676,884 | effect coval photoconjug affibodi epiderm growth factor receptor egfr cellular quiescenc cellular quiescenc revers state cell cycl arrest wherebi cell temporarili maintain nondivid phase induc quiescenc cancer cell target growth receptor treatment strategi slow cell growth certain aggress tumor turn increas efficaci treatment surgeri system chemotherapi howev ligand interact cell receptor induc receptor mediat endocytosi follow proteolyt degrad limit durat cellular quiescenc report effect target coval affibodi photoconjug epiderm growth factor receptor egfr egfr posit mda mb breast cancer cell first coval conjug affibodi cell increas doubl time two fold reduc erk activ compar cell treat fda approv anti egfr antibodi cetuximab bind egfr noncoval distribut cell phase cell cycl determin cell conjug affibodi demonstr accumul g phase indic g cell cycl arrest final prolif capac cell determin incorpor ethynyl deoxyuridin ki elisa assay show percentag prolif cell photoconjug affibodi half found untreat control | D066246;D055668;D011993 | T116;T123;T192;T070;T126 |
34,676,883 | anim metric track contribut new approach method reduc anim use mani compani global regulatori program express intent move away vivo anim test new approach method nam part product safeti assess nam includ non anim approach test assess comput base model chemico vitro model allow faster data generat potenti greater relev human avoid anim use monitor progress implement nam organ first must defin scope start definit anim eg mammal vertebr applic studi eg anim use hous experi contract research organ part environment monitor next organ must establish baselin anim use includ defin rule inclus exclus anim ensur consist futur assess last organ must establish metric anim save base util nam data paper present one approach establish anim use metric toxicolog program dow chemic compani premis program nam inform valu anim save valu depend data use eg research develop screen regulatori requir level certainti intern decis make manuscript provid metric impact nam allow quantit assess anim use number time account resourc spent nam develop identif area nam develop still need approach refin use organ | D000826;D019985 | T062;T081 |
34,676,880 | exosom micrornaa promot trophoblast migrat prolifer repress angiogenesi regul express level vegfa preeclampsia global morbid rate preeclampsia pe matern death associ pe howev mechan pathogenesi remain unknown aim present studi examin relationship micrornaa mira pe first relat express level mira placent tissu patient pe normal control analyz use revers transcriptionquantit pcr mira express upregul pe tissu particular sever pe subsequ htrsvneo cell transfect mira vector overexpress mira overexpress mira mark promot cell prolifer coloni format migrat invas vitro subsequ present studi examin function exosom secret htrsvneo cell transfect mira vector compar negat control vector group mira express mark increas exosom mira overexpress group addit exosom mira overexpress repress huvec invas ring format luciferas report assay indic vegfa direct target mira mira express negat correl vegfa express conclus present result demonstr upregul mira may promot htrsvneo cell prolifer migrat invas repress angiogenesi target vegfa indic mira may potenti target develop pe therapi | D049109 | T043 |
34,676,879 | micrornacp suppress intervertebr disc degener target rapcerk signal intervertebr disc degener idd major caus lower back pain high morbid associ diseas diminish qualiti life affect microrna mir play crucial role various diseas includ idd howev mechan via mircp play role develop idd remain unknown present studi aim investig effect mircp progress idd under mechan express level mircp evalu intervertebr disc tissu patient idd construct idd cell model nucleus pulposus np cell treat lipopolysaccharid lps h follow transfect mircp mimic inhibitor luciferas activ assay perform revers transcriptionquantit pcr western blot conduct determin rna protein express level respect express level mircp intervertebr disc tissu patient idd lower normal subject lps treatment reduc express level mircp np cell moreov mircp mimic inhibit lpsinduc np cell apoptosi found mircp attenu inflammatori cytokin level extracellular matrix ecm degrad np cell furthermor mircp target rasrel protein c rapc np cell rapc promot apoptosi inflammatori cytokin level ecm degrad activ erk signal knockdown rapc inhibit erk signal sch partial revers proinflammatori effect mircp inhibitor lpstreat np cell thus mircp inhibit np cell apoptosi inflammatori cytokin level ecm degrad idd target rapcerk signal | D015398 | T043;T044 |
34,676,870 | longitudin associ actigraphi assess sleep physic growth first month life suboptim sleep associ obes sequela children adult howev studi examin associ sleep physic growth infant experi rapid chang sleepwak pattern examin longitudin associ chang object assess sleepwak pattern chang growth age month | D056044;D012890 | T040;T033;T060 |
34,676,869 | postur control eleph largest extant leg anim eleph arguabl face extrem challeng stabl stand studi investig displac centr pressur eleph quiet stand found averag amplitud oscil later fore aft direct less cm amplitud postur oscil compar dog speci suggest aspect sensorimotor postur control scale size | D004606 | T015 |
34,676,868 | simpl model highlight differ walk biomechan young children adult adult conserv metabol energi walk minim step step transit work perform leg doubl support util spring like mechan leg littl known whether children util mechan gain better understand studi children year adult modul mechan metabol demand walk prefer speed across slow prefer fast step frequenc quantifi posit mass specif work done trail leg step step transit leg spring like behavior singl support averag children walk greater net cost transport cot j kg adult p yet group increas net cot vari step frequenc scale speed children generat fold less trail limb posit scale mechan work step step transit p unlik adult children modul trail limb posit work meet demand walk prefer step frequenc singl support young children oper stanc limb much greater complianc adult versus p observ suggest mechan walk children age year fundament distinct mechan walk adult may help explain child higher net cot insight implic design assist devic children suggest children simpli treat scale version adult | D007866;D016138 | T023;T169;T056 |
34,676,867 | alter stress relat glucocorticoid endocannabinoid hair chronic cocain user previous research anim human demonstr potenti role stress regulatori system hypothalam pituitari adren hpa axi endocannabinoid ecb system develop substanc use disord thus investig alter hpa ecb marker individu chronic cocain use disord use advanc hair analysi techniqu | D003042;D003348 | T131;T121;T109;T125 |
34,676,858 | threshold photoelectron spectroscopi methyladenin theori experi present combin experiment theoret studi singl photon ionize methyladenin gas phase addit tautomer sever rotam due rotat methyl group may exist comput show howev sole one rotam contribut low popul molecular beam andor unfavor franck condon factor upon ionize experiment use vuv radiat avail desir beamlin synchrotron radiat facil soleil record threshold photoelectron spectrum molecul ev spectrum consist well resolv band assign main vibron level cation state plus contribut state two larg band correspond electron excit state adiabat ionize energi measur ev close agreement comput valu use explicit correl coupl cluster approach includ core valenc scalar relativist zero point vibrat energi correct work shed light complex pattern lowest doublet electron state comparison canon adenin reveal methyl induc electron structur complic may import understand effect ioniz radiat charg distribut biolog entiti differ time scale | D000225;D014732 | T070;T114;T123 |
34,676,852 | thermodynam adsorpt alcohol dehydrogenas gold nanoparticl surfac model base analysi versus direct measur character nanoparticl protein corona gain tremend import late paramet quantit establish specif nanoparticl protein interact need measur accur sinc good qualiti data necessari elucid under mechan accur molecular dynam simul employ surfac sensit second harmon light scatter shls investig adsorpt tetramer protein alcohol dehydrogenas adh saccharomyc cerevisia kda nm nm nm nm citrat cap gold nanoparticl gnps aqueous phosphat buffer ph extract bind constant number adh bound per gnp gibb free energi g decay second harmon scatter signal function protein concentr use modifi version langmuir adsorpt isotherm data obtain check anoth techniqu dynam light scatter use modifi langmuir model mlm bind constant measur two method agreement number adh bound gnp obtain two method vari lot order probe bind independ model fit use orthogon fluoresc assay measur number adh bound gnp direct model fit necessari use temperatur depend shls measur heat adsorpt h entropi adh gnp corona format found equilibrium bind constant k b obtain shls order format gnp adh corona spontan g kj mol howev adsorpt modest endotherm accompani larg increas entropi state differ gnp adh corona format entrop driven perhap due tremend disrupt water structur negat charg interfac upon arriv protein within bond distanc believ shls techniqu high sensit reliabl low concentr nanoparticl protein quantit estim thermodynam paramet nanoparticl protein corona format mani techniqu may fall short | D013816 | T090 |
34,676,851 | har select pet ent catalysi chlorophyl synthes n alkyl quinolin h one isoquinolin h one trioxan photocatalyt synthes quinolin h one isoquinolin h one trioxan achiev select photo induc electron transfer pet energi transfer ent respect chlorophyl visibl light irradi quinolin h one isoquinolin h one trioxan biolog potent scaffold synthes follow mild reaction protocol high sought work showcas diverg photocatalyt role chlorophyl viz electron transfer case quinolin isoquinolin energi transfer allyl alcohol substrat afford aerob oxid green reaction condit mechanist investig affirm catalyt cycl follow electron transfer pathway carri oxid n alkyl iso quinolinium salt furthermor method provid environment benign simpl reaction strategi organ transform n heterocycl | D011804 | T109 |
34,676,842 | methyl trifluoromethyl substitut strategi increas membran permeabl short peptid investig effect ch cf substitut membran permeabl peptid synthes seri peptid cf group correspond nonfluorin peptid measur membran permeabl peptid result demonstr ch cf substitut use increas membran permeabl di tri peptid | D010455 | T116;T121 |
34,676,841 | intestin microbiom metabolom analys reveal metabol disord earli stage renal transplant renal transplant effect treatment end stage renal diseas long term prognosi organ transplant ideal recent year import gut microb metabolit studi diseas mechan gradual receiv attent howev coordin gut microb metabol renal transplant patient need studi integr sequenc metabolom data describ chang serum fecal metabolit renal transplant patient data reveal gut microbi divers decreas relat abund mani bacteria enterococcus streptococcus signific chang transplant addit larg number amino acid peptid serum fece signific chang suggest abnorm amino acid metabol transplant spearman correl analysi reveal chang co metabol pattern gut microb host metabol transplant furthermor enterococcus found correl renal function metabolit reflect renal damag studi provid potenti gut microb metabolit impact renal health help understand renal damag patient kidney transplant | D000069196;D016030;D008659 | T007;T047;T001;T061 |
34,676,840 | cantharidin load biomimet mof nanoparticl cascad enhanc fenton reaction base amplifi phototherm therapi treatment effici fenton reaction expect great restrict due problem ineffici deliveri fenton catalysi limit h concentr uneven tumour tissu accur phototherm therapi ptt could improv effici fenton catalysi extent rais temperatur howev heat shock respons hsr tumour cell caus ptt fenton reaction would attenu treatment effect studi develop iron ion mediat fenton reaction combin ptt treatment platform base metal organ framework ie ppi ctd mil mpcm nanoparticl pcmm nps explor inhibitori effect pcmm nps heat shock respons hsr pcmm nps could accumul tumour tissu via coat macrophag cell membran mpcms target inflammatori tissu phototherm effect polypyrrol ppi acceler releas cantharidin ctd iron ion load pcmm nps ctd hsr inhibitor could inhibit respons tumour cell improv effect ptt meanwhil heat generat ptt process could improv effici fenton reaction studi suggest pcmm nps could serv combin treatment platform enhanc fenton reaction base amplifi phototherm therapi | D002193;D053758 | T121;T073;T109;T131;T204 |
34,676,837 | multifunct bodipi effect inactiv gram posit bacteria promot wound heal bacteri infecti diseas antimicrobi resist serious endang human health altern therapi bacteri infect urgent need recent photodynam therapi bacteria shown great potenti high effici low acquir resist design synthes dipyrromethen boron difluorid bodipi photosensit contain guanidin group libdp combat bacteri infect posit charg guanidin destroy bacteri membran inhibit prolifer bacteria certain extent upon light irradi libdp produc reactiv oxygen speci ros destroy pre form biofilm induc potent antibacteri activ addit guanidin libdp oxid nitric oxid generat ros improv antibacteri effect also promot wound heal strategi work pave way synthes high perform antibacteri materi | D006094;D010778 | T007;T061 |
34,676,835 | phosphor pentoxid free bioactiv glass exhibit dose depend angiogen osteogen capac retain glass polymer composit scaffold bioactiv glass bgs attract materi bone tissu engin bioactiv osteoinduct studi report synthesi novel phosphor pentoxid free silic base bioactiv glass bg compos sio na cao wt glass thorough character biocompat osteogen properti bg particl analyz vitro human adipos deriv mesenchym stem cell admsc human osteoblast bg particl biocompat induc miner matrix deposit express osteogen marker runx alkalin phosphatas osteocalcin osteopontin collagen angiogen marker vascular endotheli growth factor vegf angiogen properti addit confirm zebrafish embryo model bg ad poli caprolacton pcl obtain composit wt glass content composit pcls bg scaffold fabric addit manufactur display high poros pore interconnect incorpor bg particl increas young modulus pcl scaffold mpa admsc seed effici prolifer higher pcls bg compar pcl scaffold indic improv biocompat final bg incorpor improv scaffold osteogen angiogen properti increas miner deposit induc relev gene express vegf protein secret overal bg particl pcls bg composit may attract divers bone engin applic requir concomit angiogen properti | D001672;D015027 | T013;T122 |
34,676,833 | safeti venous thromboprophylaxi low molecular weight heparin children ulcer coliti evalu increas rectal bleed follow enoxaparin thromboprophylaxi children hospit ulcer coliti uc | D003093;D054556 | T047 |
34,676,822 | enhanc nation surveil sever acut respiratori infect sari within covid surveil slovenia week monitor trend sever covid morbid slovenia week nation week rate sever acut respiratori infect sari case test posit sar cov admiss hospit vari case per popul without previous covid diagnosi sari covid admiss rate rang per unvaccin per fulli vaccin individu nation sari covid surveil essenti inform covid respons | D000086382;D007251;D012141 | T047;T067 |
34,676,821 | four week lockdown covid pandem germani week serial cross section survey risk percept knowledg public trust behaviour march backgrounddur covid pandem public percept behaviour adapt rapid new risk scenario radic behaviour restrictionsaimto identifi major driver accept protect behaviour week transit virtual covid case nationwid lockdown germani march methodsa serial cross section onlin survey administ week ca uniqu individu four data collect round march use non probabl quota sampl repres german adult popul year term age sex feder state n accept restrict regress sociodemograph variabl time psycholog variabl eg trust risk percept self efficaci extract homogen cluster base knowledg behaviourresultsaccept restrict polici increas particip age employ healthcar sector cognit particular affect risk percept signific predictor accept increas time trust institut becam relev trust media becam less relev cluster analysi indic higher educ increas gap knowledg behaviour trust institut relat convers knowledg actionconclusionidentifi relev principl increas accept remain crucial develop strategi help adjust behaviour control pandem possibl year come base find provid oper recommend health author regard data collect health communic outreach | D000086382;D058873 | T047;T067 |
34,676,820 | rapid dose depend effici inactiv surfac dri sar cov nm uv c irradi covid pandem urg cheap reliabl rapid technolog disinfect decontamin one frequent propos method ultraviolet uv c irradi uv c dose necessari achiev inactiv high titr sar cov poor defin | D000086382;D000086402 | T047;T005;T067 |
34,676,819 | increas invas diseas caus haemophilus influenza b netherland incid respiratori transmit diseas decreas covid pandem result contain measur contrast netherland note increas invas diseas caus haemophilus influenza b hib discuss factor may contribut rise | D000086382;D006192;D018073;D019741 | T007;T047;T121;T129;T067 |
34,676,817 | toxic effect methomyl mous oocyt possibl mechan methomyl broad spectrum carbam insecticid varieti toxic effect human anim howev studi toxic methomyl femal mammalian oocyt studi investig toxic effect environment oestrogen methomyl exposur mous oocyt matur possibl mechan result indic methomyl exposur inhibit polar bodi extrus mous oocyt compar control group methomyl treatment group superoxid anion free radic oocyt signific increas addit mitochondri membran potenti metaphas ii stage oocyt methomyl treatment group signific decreas result reduc mous oocyt qualiti h exposur methomyl metaphas stage mous oocyt display abnorm spindl morpholog mrna express pro apoptot gene bax caspas methomyl treat oocyt increas confirm apoptosi collect result indic mous oocyt matur defect methomyl treatment least disrupt spindl morpholog mitochondri function induct oxid stress | D008724;D009865 | T131;T025;T109 |
34,676,816 | suicid bomb terror suicid bomb context warfar exist throughout histori exponenti rise attack decad follow initi war terror health care implic attack grow concern across emerg respons sector studi epidemiolog examin terror relat bomb sustain compar rate fatal injuri fi non fatal injuri nfi suicid bomb attack sba versus non suicid bomb attack nsba | D001753;D013405;D023481 | T033;T054;T037 |
34,676,815 | review method preserv male fertil male infertil respons men health problem alway concern person social issu survey global statist suggest increas infertil rate one critic issu document studi differ way maintain fertil men depend age paper review preserv method use fertil treatment iran countri avail data review googl scholar pubm scopus web scienc iranmedex medlib irandoc scientif inform databas search articl publish use medic subject head mesh term cryopreserv sperm testicular spermatogonia stem cell male infertil andor iranian world provid evid evalu fertil preserv method base search strategi manuscript found review titl abstract manuscript entireti articl obtain select accord elig criteria studi mention divid three categori sperm testi spermatogonia stem cell sscs method fertil preserv investig way maintain male fertil differ depend age includ sperm testicular ssc freez number studi testicular tissu sscs low human sampl studi still need sperm freez infertil centr top male fertil preserv | D059247;D007248 | T033;T047;T184;T061 |
34,676,810 | avail key determin palliat home care set patient famili caregiv perspect quantit qualit content analysi approach sens secur import palliat home care yet knowledg compon contribut feel secur patient famili caregiv perspect especi sinc introduct specialist palliat home care spars goal current studi determin key compon contribut sens secur relat experienc patient famili caregiv specialist generalist palliat home care | D006699;D009369 | T058;T191 |
34,676,809 | inform caregiv older muslim diagnos cancer portrait depress social support faith islam popul constitut world popul grow rapid nevertheless data concern inform caregiv older muslim patient diagnos cancer scarc improv well caregiv vital step optim care patient throughout muslim communiti world studi focus sampl palestinian caregiv older muslim patient diagnos cancer live east jerusalem west bank gaza studi aim describ socio demograph characterist caregiv understand social support identifi predictor caregiv depress | D017028;D009369 | T097;T191;T098;T099 |
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