PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,676,668 | evalu inject hydrogel base hyaluron acid chitosan glycerophosph load mesenchym stem cell enhanc therapeut efficaci myocardi infarct myocardi infarct mi due cardiac dysfunct result morbid mortal moreov cellular activ transplant mesenchym stem cell mscs general limit therapeut efficaci treatment mi inject abl hyaluron acid chitosan glycerophosph ha cs gp hydrogel load mscs prepar effect treatment mi investig synthes ha cs gp hydrogel exhibit swell ratio vitro degrad valu gelatin time respect rheolog studi reveal elast modulus ha cs gp hydrogel pa exhibit larg elast viscous modulus ratio indic mechan strength furthermor vitro cell msc cultur studi confirm good biocompat ha cs ha cs gp hydrogel implant synthes hydrogel mous mi model consider improv therapeut effect mscs enhanc cardiac function reduc cardiomyocyt apoptosi increas vascular first time innov synergist strategi combin inject ha cs ha cs gp hydro gel mscs may suitabl effect treatment cardiac morbid due mis | D048271;D059630;D009203 | T025;T047;T121;T109 |
34,676,667 | introduct special seri incorpor natur base solut built environ incorpor natur base solut nbss built environ support ongo sustain challeng emphas unit nation sustain develop goal sdgs particular relev sdg goal sustain citi communiti seek greater effici urban plan manag practic address age infrastructur ongo air water soil pollut short communic research articl special seri exemplifi mani aspect highlight applic nbss showcas latest environment research polici solut support natur base solut built environ aim promot understand transdisciplinari natur nbss enhanc global awar valu nbss provid divers solut illustr posit econom social environment benefit nbss built environ integr environ assess manag author integr environment assess manag publish wiley period llc behalf societi environment toxicolog chemistri setac | D054750;D004787 | T091;T069 |
34,676,666 | traf protein key regul plant develop stress respons tumor necrosi factor receptor associ factor traf protein conserv higher eukaryot play key role transduc cellular signal across differ organell character c termin region traf c domain contain seven eight anti parallel sheet also known meprin traf c homolog math domain past decad signific progress made toward understand divers role traf protein mammal plant compar eukaryot speci arabidopsi thaliana rice oryza sativa genom encod mani trafmath domain contain protein plant protein cluster five class trafmath math bpm math ubp ubiquitin proteas seven absentia sina math filament math pear protein suggest parallel evolut traf protein plant increas evid indic plant traf protein form central signal network essenti multipl biolog process veget reproduct develop autophagosom format plant immun symbiosi phytohormon signal abiot stress respons summar recent advanc highlight futur prospect understand molecular mechan traf protein act plant develop stress respons | D017360;D029681;D001686 | T070;T116;T038;T002 |
34,676,665 | factor associ obliter follow stereotact radiosurgeri patient brain arterioven malform meta analysi various factor report affect obliter brain arterioven malform avm follow stereotact radiosurgeri srs meta analysi conduct identifi factor potenti associ avm obliter srs | D002538;D016634 | T019;T061 |
34,676,664 | post oper ileus definit mechan controversi post oper ileus poi syndrom impair gastrointestin transit occur follow abdomin surgeri effect target therapi ileus research limit inconsist definit incomplet understand under pathophysiolog despit consider effort remain wide adopt definit ileus recent work identifi variat outcom report major sourc heterogen clinic trial outcom clear defin clinic relev reflect under biolog impact hospit resourc qualiti life collabor effort need develop consensus definit core outcom set postop gastrointestin recoveri investig pathophysiolog poi hinder use low resolut techniqu difficulti link cellular mechan dysmotil pattern clinic symptom recent evid suggest common assumpt post oper gi paralysi incorrect distal colon becom hyperact follow surgeri post oper inflammatori respons import pathophysiolog ileus time cours human remain unclear major evid come anim model futur work investig dysmotil pattern under ileus identifi biomark may use diagnos monitor stratifi patient ileus | D045823;D011788 | T047;T078 |
34,676,662 | real world evid biolog treatment moder sever psoriasi itali result canova effect biolog treatment plaqu psoriasi itali observ longitudin studi real life clinic practic studi effect biolog treatment plaqu psoriasi itali observ canova studi aim provid real world evid effect biolog italian patient moder sever psoriasi observ retro prospect cohort studi conduct italian dermatolog clinic adult patient moder sever plaqu psoriasi start biolog treatment week month enrol includ follow visit month enrol patient least month observ primari object describ clinic respons rate pasi week biolog treatment start secondari outcom sustain respons qualiti life treatment satisfact elig patient male nave biolog though mean durat psoriasi sinc first diagnosi year sd frequent prescrib biolog secukinumab ustekinumab tnf inhibitor ixekizumab pasi achiev patient ci week week week patient achiev pasi pasi week respect sustain pasi respons year treatment start achiev patient mean dlqi total score sd enrol decreas final visit high level treatment satisfact express patient studi period larg real world studi confirm clinic practic good effect accept biolog psoriasi patient | D001688;D011565 | T047;T121;T123 |
34,676,660 | earli symptom chang predict subsequ cours depress symptom psychotherapi previous studi report influenc earli chang treatment respons howev question whether earli chang predict subsequ cours depress symptom treatment psychotherapi yet clear answer aim investig whether symptom cours first week level individu session predict symptom progress session session level psychotherapi treatment patient major depress md | D015928;D003865 | T048;T061 |
34,676,659 | make exercis count consider role exercis back pain treatment chronic low back pain clbp pain persist greater three month common burdensom repres signific proport primari health present major peopl clbp specif nocicept contributor reliabl identifi pain categoris non specif exercis therapi recommend intern clinic guidelin first line treatment non specif clbp | D017116 | T047;T184 |
34,676,658 | import address multipl risk marker type diabet result leader sustain trial investig extent multipl risk marker improv confer lower risk cardiovascular kidney complic contemporari type diabet popul | D002318;D003924;D007674 | T047 |
34,676,656 | evalu efficaci atmospher pressur plasma diabet ulcer heal random clinic trial aim studi evalu efficaci safeti cold atmospher plasma cap novel therapi diabet foot ulcer investig blind random control trial week week treatment week follow twenti patient diabet foot ulcer divid two group control group receiv standard wound care plasma group receiv cap twice week six consecut week addit standard wound care ulcer size amount exud wound grade determin week cold plasma produc appli high voltag kv high frequenc khz helium gas exud wound treat cap show signific reduct third week complet treatment p wound grade ulcer improv sixth week p size ulcer signific decreas plasma group end treatment period p random clinic trial cap effect treatment option diabet foot ulcer term wound surfac reduct antibacteri effect | D003920;D017719;D058626 | T047;T104 |
34,676,655 | defin learn curv transan total mesorect excis systemat review meta analysi transan total mesorect excis tatm repres novel approach rectal dissect although mani structur train program develop worldwid assist surgeon implement new techniqu learn curv lc tatm yet conclus defin particular import given concern regard complic profil oncolog safeti tatm aim review provid date systemat review meta analysi lc tatm compar differ outcom lc learn curv alc group | D010535;D012004;D000067368 | T061;T191;T060 |
34,676,653 | pattern insulin therapi insulin daili dose children adolesc type diabet germani describ differ insulin therapi pattern insulin daili dose children adolesc age year type diabet | D003922;D007328 | T116;T047;T121;T125 |
34,676,652 | make recoveri meaning peopl intellectu disabl recoveri approach within mental health servic gain momentum mean adult intellectu disabl recov mental health disord less understood peopl experi recoveri explor help inform recoveri focus recommend clinic practis | D006233;D008607 | T048;T101 |
34,676,650 | bright side dark side daydream predict creativ togeth brain function connect daydream creativ similar cognit process neural basi howev empir studi examin relationship daydream creativ use cognit neurosci method present studi explor relationship differ type daydream creativ common neural basi behavior result reveal posit construct daydream posit relat creativ poor attent control negat relat machin learn framework adopt examin predict effect daydream relat brain function connect fc creativ result demonstr task fcs relat posit construct daydream task fcs relat poor attent control predict individu creativ score success addit task fcs combin posit construct daydream poor attent control also signific predict effect creativ score furthermor predict analysi base rest state fcs show similar pattern subscal relat fcs combin fcs signific predict effect creativ score analysi show task rest state fcs main locat default mode network central execut network salienc network attent network result show daydream close relat creativ share common fc basi | D063132;D003405;D005201;D008279 | T170;T041;T091;T017;T060;T078;T059 |
34,676,647 | hospit surviv pancreatoduodenectomi greater high volum hospit versus lower volum hospit meta analysi variat cut valu consid high volum hv hospit made assess volum outcom relationship pancreaticoduodenectomi pd challeng accord perform systemat review meta analysi compar hospit mortal pd hospit hv threshold various cut valu | D061847;D016577 | T061;T093;T073 |
34,676,645 | immunopathogenesi manag polymorph light erupt polymorph light erupt ple common immunolog mediat photodermatosi demonstr mani abnorm caus critic failur ultraviolet uv induc immunosuppress uniqu express antimicrobi peptid ple like determin alter microbiom compon upon uv exposur implic possibl trigger role pathogen signific erupt review aim clarifi current knowledg regard immunolog disturb correl ple serv base better understand molecular pathogenesi diseas develop new therapeut strategi prevent treatment broad spectrum suncreen sunscreen contain dna repair enzym well natur photoharden graduat exposur sunlight earli spring could suffici milder case antioxid topic calcipotriol promis approach adjuv prevent phototherapi main narrow band uvb ray appropri method sever case diseas establish treatment option ple includ local system glucocorticoid system nonsed antihistamin itch relief rare immunosuppress drug refractori case like medic photoharden afamelanotid potenti photoprotect induc melan skin afamelanotid believ possibl new treatment option sever refractori case ple target main pruritogen cytokin il open new road develop novel therapeut approach combat moder sever itch case ple intens pruritus | D010787 | T047;T037;T046 |
34,676,644 | lulworthioid fungi dark septat endophyt domin mediterranean seagrass posidonia oceanica previous studi sicili itali indic domin mediterranean seagrass posidonia oceanica form dark septat endophyt dse associ lulworthioid fungus lulwoana sp conflict sever studi nw mediterranean sea point recent describ pleosporalean fungus posidoniomyc atricolor collect p oceanica root eight site around sicili check fungal colon use light microscopi three site root fungal symbiont mycobiont isol pure cultur identifi use rdna sequenc posidoniomyc atricolor repres frequent mycobiont isol close follow lulworthioid fungi obtain mycobiont spectrum also includ cladosporium alternaria corollospora fusarium penicillium vishniacozyma isol characterist dse root colon similar occur terrestri plant known seagrass found investig p oceanica individu microscopi screen suggest p atricolor respons observ dse colon studi extend known rang pos atricolor dse associ characterist p oceanica southern tyrrhenian seasicili lulworthioid fungi regular occur p oceanica tissu includ termin fine root signific function eg parasit pathogen endophyt unknown requir investig howev current proof belong among dark septat endophyt seagrass | D035961;D060026 | T004;T002 |
34,676,643 | efficaci safeti botulinum toxin inject reduc deltoid muscl hypertrophi increas demand bodi contour botulinum toxin btx inject wide use label muscular hypertrophi howev best knowledg studi investig clinic efficaci btx type btx deltoid muscl hypertrophi studi conduct evalu efficaci safeti intramuscular inject btx reduc deltoid muscl hypertrophi overal patient bilater deltoid muscl hypertrophi treat intramuscular inject prabotulinum toxin total unit u administ per patient measur ultrasonographi thick deltoid muscl signific decreas week addit clinic assess score blind investig improv treatment howev patient satisfact score relat low major complic report therefor intramuscular inject btx seem candid novel treatment option deltoid muscl hypertrophi larger clinic studi warrant confirm efficaci btx | D019274;D057645;D006984 | T116;T023;T121;T109;T129;T046;T131 |
34,676,641 | hydrogen sulphid regul growth tomato root cell affect cell wall biosynthesi cuo nps stress copper oxid nanoparticl cuo nps show strong nano toxic effect organ hydrogen sulphid h play pivot role plant respons abiot stress studi examin crucial role cell wall regul h respons cuo nps stress digest method employ determin cu content use atom absorpt spectrometri trakin pro tubulin stain kit use investig microtubul cytoskeleton use confoc laser scan microscopi cell wall compon analysi util ic hplc system applic h reduc growth inhibit caus cuo nps furthermor cuo nps accumul root indic low transfer rate h signific decreas cuo nps content root leav stem subcellular distribut analysi impli cu accumul root cell wall h reduc content cu root cell wall cortic microtubul plasma membran guid cell wall biosynthesi h obvious allevi microtubul cytoskeleton disord caus cuo nps addit content cellulos hemicellulos pectin monosaccharid root cell wall reduc cuo nps treatment h enhanc monosaccharid polysaccharid content compar cuo nps treatment conclus h regul cell wall develop respons cuo nps stress stabil microtubul h affect cu distribut allevi growth inhibit tomato seedl research result provid theoret basi studi nano toxic regul plant | D006862;D018551 | T002;T130;T168;T131;T197 |
34,676,640 | pediatr discoid lupus erythematosus short report pediatr discoid lupus erythematosus dle rare inflammatori skin disord articl aim review avail clinic therapeut data report case pediatr dle systemat review literatur conduct use pubm embas limit public date sex nation thirti two articl includ case mean age year month year f ratio lesion locat head neck dissemin case associ symptom pruritus alopecia progress system lupus erythematosus sle concurr sle statist signific predictor progress sle onset symptom age year p treatment consist main sunscreen topic corticosteroid oral antimalari retrospect natur includ studi small sampl size short durat follow limit data patient demograph pediatr dle affect most head neck femal predomin possibl associ inflammatori autoimmun diseas overal good treatment respons prognosi | D001327;D008179;D008180 | T047 |
34,676,636 | patient compet cope self efficaci cope chang oncolog inpati rehabilit beyond construct patient compet pcs suggest allow comprehens understand cancer patient abil confront emot problem focus cope task aris diagnosi treatment survivorship cancer provid reliabl valid measur pcs research thus far clarifi whether pcs chang across time andor intervent studi ask whether pcs chang oncolog inpati rehabilit beyond | D007297;D020377 | T041;T101 |
34,676,634 | haemorrhag death sever liver trauma decreas era haemostat resuscit sever liver trauma caus major haemorrhag death haemostat resuscit principl associ improv surviv trauma patient major haemorrhag hypothesis death liver haemorrhag decreas parallel introduct haemostat resuscit | D006490;D014947 | T121;T037 |
34,676,633 | outcom adjunct therapi post hedgehog inhibitor manag local advanc basal cell carcinoma systemat review pool analysi manag patient local advanc basal cell carcinoma labcc tradit strategi yield suboptim outcom target treatment includ hedgehog inhibitor therapi hhit present limit util monotherapi herein report evid base outcom avail literatur multimod treatment adjuv hhit labcc manag util systemat search strategi pubm identifi studi publish incept april screen definit inclusionexclus criteria perform individu studi qualiti assess pool analysi assess impact adjunct treatment base respons post hhit clinic respons recurr outcom twenti nine studi n includ primari find includ complet respons cr rate median follow month post hhit complet recurr rate month median time recurr moh micrograph surgeri mms cr post hhit differ observ surgeri radiat therapi rt mms surgeri compar year recurr free rate rfr respect rt lower year rfr male gender portend advanc stage diagnosi wors outcom subset analysi periorbit labcc orbit involv cr rate versus without orbit involv similar rate recurr limit avail quantit data possibl public bias limit pool analysi observ data support use adjunct therapi post hhit improv treatment respons patient labcc longer term follow need studi recurr rate combin therapi | D000970;D002280;D012878 | T191;T121;T109 |
34,676,632 | compar concentr heavi metal two bivalv speci santo bay brazil subsidi understand assimil dynam bivalv contamin contamin substanc consist chemic element present potenti advers impact ecolog environ thus repres threat local fauna flora context heavi metal critic agent depend natur level potenti toxic live organ order evalu bioaccumul heavi metal santo estuari determin potenti influenc salin gradient heavi metal bioconcentr present studi measur concentr cd pb cu cr fe ni zn two bivalv speci crassostrea rhizophora perna perna sampl differ site santo bay southeastern region brazil throughout studi sentinel speci use effect bioaccumul contamin oyster base brazilian legisl critic limit exceed zn cu cr case mussel hand zn cr critic limit overcom present studi obtain data suggest salin determin paramet incorpor process bivalv mollusk practition point present studi present import result develop environment manag polici estuarin environ present studi point differ differ organ biomonitor provid subsidi decis effect biomonitor program present studi discuss valu contamin danger public health santo bay extrapol similar environ around world | D049872;D019216;D014874 | T131;T204;T196 |
34,676,631 | age reduc skin wet sensit across bodi central question studi age impair skin thermal tactil sensit age also induc loss skin wet sensit main find import older adult show averag loss skin wet sensit sensori deficit mediat combin reduct skin tactil sens hydrat status find increas knowledg wet sens mechan across lifespan | D012879;D055698 | T070;T042;T041 |
34,676,630 | trend fall relat encount predictor non transport us emerg medic servic agenc non transport hospit emerg medic servic em encount fall common howev incid factor associ non transport well studi especi beyond older adult object studi describ trend fall relat em utilis among adult patient describ incid characterist age identifi incid factor associ non transport follow fall retrospect observ studi includ prehospit clinic record data fall larg ambul servic minnesota usa multivari logist regress use assess independ associ non transport follow factor sex age race previous fall relat em encount incid locat primari impress fall relat encount studi result transport em fall call less common among younger peopl locat medic condit primarili treat em provid call differ great occur among patient older factor strong associ increas risk non transport multivari model primari impress appar illnessinjuri ci fall public locat ci fall relat em encount prior year ci fall occur public locat patient previous fall result clinic detect appar ill injuri signific increas odd non transport non transport fall incid unit state requir signific agenc resourc knowledg incid factor associ non transport call inform develop altern model prehospit care deliveri initi better serv patient | D004632 | T058;T093;T061 |
34,676,628 | castrat induc circrna expression chang subcutan adipos tissu male pig circular rnas circrna particip regul lipid metabol howev function role castrat induc lipid deposit deepli research research first compar circrna expression differ subcutan adipos tissu intact castrat male huainan pig total differenti express circrna dec detect two group log foldchang p adj go kegg analysi show parent gene main enrich metabol relat pathway tgf beta insulin ampk mapk pathway might play vital role castrat induc lipid deposit mirna enrich construct circrna mirna network main particip adipogenesi lipid metabol mir p mir mir verifi testosteron upregul mir downregul circ express dose depend manner porcin intramuscular adipocyt overexpress mir inhibit circ taken togeth dec may particip regul lipid metabol castrat reaction mirna indic novel role circrna castrat induc lipid deposit | D000273;D002369;D000079962 | T024;T114;T061;T201 |
34,676,627 | predict impact chronic kidney diseas cardiac sympathet nervous activ lethal arrhythm event chronic heart failur clinic implic chronic kidney diseas ckd cardiac sympathet nervous activ csna regard lethal arrhythm event yet fulli elucid patient chronic heart failur chf hypothes combin ckd abnorm csna assess metaiodobenzylguanidin mibg scintigraphi may provid use prognost inform lethal arrhythm event | D017147;D006333;D051436 | T047;T074;T046 |
34,676,625 | parallel attent augment bilinear network earli magnet reson imag base diagnosi alzheim diseas structur magnet reson imag smri captur spatial pattern brain atrophi alzheim diseas ad incipi dementia recent mani smri base deep learn method develop ad diagnosi method util neural network extract high level represent basi handcraft featur other attempt learn use featur brain region propos separ modul howev method requir consider manual engin stepwis train procedur would introduc cascad error propos parallel attent augment bilinear network novel deep learn framework ad diagnosi base convolut neural network framework direct learn global local featur smri scan without prior knowledg framework lightweight suitabl end end train evalu framework two public dataset adni adni contain subject ad classif mild cognit impair convers predict task framework achiev competit result furthermor generat heat map highlight discrimin area visual interpret experi demonstr effect propos framework medic prior unavail comput resourc limit propos framework general medic imag analysi effici interpret | D000077321;D018450 | T033;T046;T066 |
34,676,624 | sweet food specif inhibitori control train via mobil applic improv eat behavior children obes consumpt excess sugar common energi dens nutrient poor food risk factor obes school age children food specif inhibit train respons palat food stimuli sweet food consist repeat inhibit reduc sweet food intak adult howev studi yet examin effect inhibitori control train specif target sweet food among children high sugar crave examin whether sweet food specif inhibitori control train sf ict administ via mobil app reduc choic consumpt sweet food weight sampl children age overweight obes high sugar crave n | D063731 | T170 |
34,676,621 | l cystein modifi fe nanoparticl novel heterogen catalyst persulf activ btex remov l cystein modifi fe nanoparticl l cys nfe synthes success use catalyst activ persulf ps benzen toluen ethylbenzen xylen btex degrad composit fulli character l cys nfe protrus l cys combin surfac nfe remov btex respect psl cys nfe system btex remov reach condit nfe chelat l cys h four success cycl btex degrad complet psl cys nfe system synergist mechan btex degrad psl cys nfe system investig electron paramagnet reson epr benzoic acid ba probe x ray photoelectron spectroscopi xps test sfe bond l cys fe complex promot electron transfer nfe core solut iron iron interfac therebi promot fe fe cycl catalyt capac nfe optim ph psl cys nfe system hco cl exhibit negat influenc btex degrad btex remov presenc ps gl l cys nfe actual groundwat condit howev expand dosag ps l cys nfe effect strategi overcom advers effect practition point l cys nfe synthes success use catalyst activ ps btex degrad four success cycl btex degrad complet psl cys nfe system ls fe bond l cys nfe promot electron transfer ps nfe core | D053758;D014874 | T131;T073 |
34,676,620 | experi palliat care profession respons work relat stress qualit studi previous qualit research demonstr palliat care profession pcps deal wide array emot challeng issu associ care provid although previous research identifi self care strategi pcps engag lack focus respons help andor unhelp aim current studi understand describ experi pcps explor help unhelp respons work relat stress employ | D064869;D000073397 | T033;T048;T061;T054 |
34,676,618 | nurs guid incent spirometri use postop pulmonari complic among cardiac surgeri patient random control trial assess effect nurs guid use incent spiromet postop oxygen pulmonari complic coronari arteri bypass graft surgeri | D009042;D001261 | T047;T046;T041;T078;T080 |
34,676,617 | secondari end muscl spindl structur reflex action role motor control propriocept topic review describ structur function secondari sensori end muscl spindl reflex action role motor control propriocept advanc highlight mammalian skelet muscl secondari end spindl much numer primari end much less well studi focus secondari end review aim redress balanc draw attent known stimul futur research | D009470;D012018 | T023;T042 |
34,676,616 | impact whole bodi resist exercis time mitig hyperglycaemia induc vascular dysfunct central question studi estrous cycl affect disus atrophi estrous cycl chang relat musculoskelet outcom main find import rodent estrous cycl alter disus atrophi correspond musculoskelet outcom howev estrous cycl appear chang lewi lung carcinoma correspond differ muscl size compar healthi control find suggest relationship estrous cycl muscl size atroph patholog | D006943;D055070 | T033;T047;T061 |
34,676,614 | lewi patholog submandibular gland lewi bodi diseas report autopsi case accumul phosphoryl synuclein central peripher nervous system histolog hallmark lewi bodi diseas lbd includ parkinson diseas pd dementia lewi bodi dlb lb relat pure autonom failur submandibular gland employ biopsi site detect lewi patholog howev incid lewi patholog region autopsi proven lbd case stage age japanes cohort remain unclear valid util lewi patholog submandibular gland diagnost biomark lbd investig submandibular gland lewi patholog autopsi patient determin specif prospect evalu submandibular gland consecut autopsi patient determin sensit retrospect assess submandibular gland consecut autopsi patient prodrom clinic lbd prospect studi lewi patholog found patient nine patient submandibular gland lewi patholog lewi patholog found patient without cns lewi patholog give specif retrospect studi lewi patholog submandibular gland detect patient sensit pd dlb sensit increas diseas progress find support util submandibular gland biopsi patholog diagnosi lbd | D020961 | T047 |
34,676,613 | rcsb protein data bank celebr year pdb new tool understand visual biolog macromolecul research collaboratori structur bioinformat protein data bank rcsb pdb fund us nation scienc foundat nation institut health depart energi serv structur biologist protein data bank pdb data consum worldwid sinc rcsb pdb found member worldwid protein data bank wwpdb partnership us data center global pdb archiv hous biomolecular structur data rcsb pdb also respons secur pdb data wwpdb design archiv keeper annual rcsb pdb serv ten thousand three dimension macromolecular structur data depositor use macromolecular crystallographi nuclear magnet reson spectroscopi electron microscopi micro electron diffract inhabit contin rcsb pdb make pdb data avail research focus rcsborg web portal charg without usag restrict million pdb data consum work everi nation territori worldwid addit rcsb pdb oper outreach educ pdbrcsborg web portal use educ student member public calendar year invit tool issu contribut describ archiv grow evolv new experiment method generat ever larger complex biomolecular structur ii import data standard data remedi effect manag archiv facil integr extern data resourc iii new tool featur structur analysi visual made avail past year via rcsborg web portal | D014584 | T170 |
34,676,612 | high fat diet caus inferior vertebr structur function without disc degener rage ko mice back pain spinal patholog associ obes juvenil adult yet studi identifi causal relationship lack none investig sex differ studi determin high fat hf diet caus structur function chang vertebra intervertebr disc ivd chang modul mice systemat ablat receptor advanc glycat endproduct rage ko chang sex depend wild type wt rage ko mice fed low fat lf hf diet week start week repres juvenil popul hf diet led weightfat gain glucos intoler increas cytokin level il mig rant less fat gain rage ko femal import hf diet reduc vertebr trabecular bone volum fraction compress shear moduli without modifi effect rage ko pronounc effect femal hf diet caus reduc cortic area fraction wt male neither hf diet rage ko affect ivd degener grade biomechan properti coccyg motion segment affect rage ko diet interact identifi conclus hf diet result inferior vertebr structur function sex differ ivd degener modifi effect rage ko structur function defici hf diet provid evid diet affect spinal structur may increas risk spinal injuri degener age addit stressor back pain spinal patholog associ obes juvenil adult yet studi identifi causal relationship lack none investig sex differ | D007403;D055959 | T190;T047;T023 |
34,676,611 | immunoglobulin nephropathi paediatr date immunoglobulin nephropathi main caus glomerulonephr global import aetiolog end stage renal diseas children consid autoimmun diseas lead product autoantibodi abnorm iga format immun complex autoantibodi immun complex deposit glomeruli result renal injuri begin iga nephropathi cours patient asymptomat first clinic manifest children macroscop hematuria proteinuria diagnosi defin detect iga mesangi deposit kidney biopsi use immunofluoresc techniqu oxford mest c score use classif associ histolog find clinic outcom valid applic children recommend treatment option antihypertens antiproteinur therapi corticosteroid immunosuppress agent non pharmacolog approach ideal prognosi indic new perspect scienc scope find possibl biomark diseas omic research review aim summar date scientif literatur paediatr iga nephropathi focus pathophysiolog clinic find histopatholog current treatment prognosi futur perspect | D005921;D005922;D010372 | T091;T047 |
34,676,610 | crystal structur anti crispr acriic cluster regular interspac short palindrom repeat crispr crispr associ protein system bacteri archaeal defens mechan invad element phage virus overcom defens system phage virus develop inhibitor call anti crispr acr capabl inhibit host crispr cas system via differ mechan although inhibitori mechan acriic acriic acriic reveal inhibitori mechan acriic acriic fulli understood structur data unavail studi elucid crystal structur type iic anti crispr protein acriic structur analysi reveal acriic exhibit helic bundl fold compris four helix biochem biophys analys show acriic form monom solut monomer acriic direct interact cas cassgrna complex discoveri structur acriic interact mode cas help us elucid divers inhibitori mechan acr protein famili | D064113 | T040 |
34,676,609 | examin motor unit fire rate steadi torqu maxim effort either explos slower rate torqu develop central question studi aim explor agonist antagonist motor unit fire rate maxim effort perform either explos slower rate torqu develop main find import antagonist muscl present motor unit fire rate relationship similar agonist muscl addit motor unit muscl exhibit higher fire rate explos maxim contract maxim contract perform slower rate torqu develop result could prove use futur research analys effect age diseas resist train andor fatigu relat alter motor unit fire rate | D053834 | T120 |
34,676,608 | histolog haemodynam character right ventricl sedentari train rat heart failur preserv eject fraction central question studi right ventricl rv dysfunct high preval heart failur preserv eject fraction hfpef near doubl risk death rv function structur chang hfpef aerob exercis impact main find import hfpef zsf rat model present rv structur function chang mimick human condit aerob exercis prevent declin v max lower surrog marker rv overload eg higher mean maximum systol pressur improv diastol dysfunct eg end diastol pressur relax time constant emphas import use exercis manag hfpef | D006333 | T047;T046 |
34,676,607 | effect red peppercapsaicin blood pressur heart rate systemat review meta analysi clinic trial sever studi assess effect red pepper blood pressur bp heart rate hr report controversi result aim studi perform systemat review meta analysi clinic trial evalu effect red peppercapsaicin consumpt bp hr medlin scopus cochran librari googl scholar systemat search databas incept august ascertain clinic trial evalu effect red pepper capsaicin systol blood pressur sbp diastol blood pressur dbp hr pool effect size calcul use random effect method perform subgroup analys discern probabl sourc studi heterogen meta analysi show signific effect red peppercapsaicin sbp mmhg ci dbp mmhg ci hr bpm ci although studi heterogen high sbp dbp could discern potenti sourc heterogen conclus red peppercapsaicin effect bp hr find interpret caution studi heterogen high well design high qualiti studi requir investig efficaci safeti red peppercapsaicin supplement bp hr | D002212;D006973 | T047;T002;T168 |
34,676,606 | recent speciat hybrid iceland deep sea isopod integr approach use genom proteom crustacean marin isopod speci haploniscus bicuspi sar show circum iceland distribut wide rang environment condit along well known geograph barrier greenland iceland faro gif ridg want explor popul genet phylogeographi cryptic speciat well investig whether previous describ unaccept subspeci merit use set specimen combin mitochondri coi sequenc thousand nuclear loci ddrad proteom profil plus select morpholog charact use confoc laser scan microscopi clsm five diverg genet lineag identifi coi ddrad two south three north gif ridg assign popul three northern lineag vari detail analys reveal hybrid gene flow suggest singl northern speci complex phylogeograph histori appar hybrid observ among lineag south gif ridg infer exist two speci differ proteom profil three putat speci minim impli ongo recent speciat process popul differenti high even among close associ popul higher mitochondri coi nuclear ddrad loci gene flow appar male bias lead hybrid zone instanc complet exchang local nuclear genom immigr male studi confirm exist subspeci defin male charact probabl instead refer differ male development stage | D033321 | T204 |
34,676,604 | celastrol attenu high fructos diet induc inflamm insulin resist via inhibit hydroxysteroid dehydrogenas type activ rat adipos tissu high fructos consumpt link low grade inflamm insulin resist result increas intracellular hydroxysteroid dehydrogenas type hsd activ celastrol pentacycl triterpen demonstr exhibit multifacet target attenu various metabol diseas associ inflamm howev under mechan celastrol exert attribut properti high fructos diet hfrd induc metabol syndrom remain elus herein present studi aim elucid mechanist target celastrol co administr upon hfrd rat evalu potenti modul hsd activ celastrol remark improv glucos toler lipid profil insulin sensit along suppress hepat glucos product rat adipos tissu celastrol attenu nuclear factor kappa b nf b driven inflamm reduc c jun n termin kinas jnk phosphoryl mitig oxid stress via upregul gene express involv mitochondri biogenesi furthermor insulin signal pathway signific improv restor akt phosphoryl level ser thr residu celastrol exhibit potent select specif inhibitor intracellular hsd toward oxidoreductas activ ic valu nm comparison hsd relat enzym inhibit hsd express rat adipos microsom reduc avail cofactor nadph substrat hpdh coupl upregul mrna protein express glucocorticoid receptor conclus result underscor like conceiv mechan exhibit celastrol hfrd induc metabol dysregul main attenu inflamm insulin resist least via specif inhibit hsd activ adipos tissu | D043205;D007333 | T116;T046;T126 |
34,676,600 | thiamidol moder sever melasma week random doubl blind vehicl control clinic studi subsequ regress phase thiamidol potent inhibitor human tyrosinas screen substanc vivo well toler improv melasma signific first week random doubl blind vehicl control cosmet clinic studi assess efficaci toler thiamidol moder sever melasma phototyp iii v subject subsequ regress phase femal alloc verum n appli daili dual serum follow either day care spf morn night care even contain thiamidol vehicl group femal follow skin care routin use correspond vehicl formul subject came back follow visit week treatment regress phase assess includ clinic photographi melasma area sever index masi skin light qualiti life toler baselin demograph hyperpigment well balanc across treatment group clinic photographi masi improv thiamidol signific versus baselin p vehicl p time point treatment end follow masi still signific lower baselin similar verum vehicl skin light qualiti life improv signific versus baselin without signific differ verum vehicl studi demonstr thiamidol well toler superior improv melasma compar baselin vehicl treatment period week | D008548;D011788 | T033;T047;T078 |
34,676,599 | german onlin survey peopl experienc sleep paralysi present key find onlin survey isol sleep paralysi aim studi get differenti pictur correl frequenc sleep paralysi sever phenomena symptom experi well factor correl phenomena also investig role gender relat experi sleep paralysi use select sampl subject least one sleep paralysi experi total subject averag particip experienc sleep paralysi episod found high expect posit correl frequenc sleep paralysi experi amount phenomena emot perceiv shape form experienc sleep paralysi increas frequenc sleep paralysi also appear lead habitu de dramat affect individu interest signific correl miss one would suspect base previous hypothes neither self perceiv general stress poor sleep hygien appear influenc frequenc sleep paralysi found high signific gender differ item women report experienc phenomena emot overal frequent sleep paralysi experi intrud incubus type signific like perceiv concret form human figur peopl know also like men report experienc fear emot especi fear go crazi find base exploratori question requir replic valid | D007319;D020188 | T048;T047;T184 |
34,676,598 | updat recent find genet hair disord genet hair disord although unusu rare dermatologist often opportun see patient signific advanc molecular genet led identifi mani causat gene genet hair disord includ recent identifi causat gene lss corf mani patient detect autosom recess woolli hairhypotrichosi japanes popul caus founder mutat liph gene addit mani patient genet hair disord caus gene report east asia includ japan understand genet hair disord essenti dermatologist find obtain analyz diseas contribut reveal mechan hair follicl morphogenesi develop human | D006201;D007039 | T047 |
34,676,596 | appli deep learn quantifi empti lacuna histolog section osteonecrosi femor head osteonecrosi femor head onfh diseas inadequ blood suppli subchondr bone caus death cell bone marrow decalcifi histolog assess percentag empti lacuna use quantifi sever onfh howev current clinic practic manual count cell tedious ineffici process util power artifici intellig train establish deep convolut neural network framework faster rcnn automat classifi quantifi osteocyt healthi pyknot empti lacuna histolog imag adjust correl coeffici train cell classifi ground truth r method detail studi signific reduc manual effort cell count onfh histolog sampl translat field imag quantif | D000077321;D005271 | T047;T066;T046 |
34,676,595 | unravel innat immun respons bombyx mori hemolymph fat bodi midgut bombyx mori nucleopolyhedrovirus oral infect metabolom analysi bombyx mori nucleopolyhedrovirus bmnpv infect caus seri physiolog patholog chang bombyx mori b mori metabolom studi innat immun organ includ hemolymph fat bodi midgut silkworm strain dazao follow bmnpv challeng conduct reveal metabol variat b mori compar control featur high qualiti featur generat posit negat mode respect bmnpv infect larva princip compon analysi supervis learn method use partial least squar discrimin analysi demonstr good analyt stabil experiment reproduc metabol profil base databas annot total differenti express metabolit dem identifi bmnpv infect group hemolymph fat bodi midgut respect main group carboxyl acid deriv fatti acyl glycerophospholipid kyoto encyclopedia gene genom databas enrich analysi dem show amino acid metabol increas h bmnpv infect bmnpv induct adopt signific alter seri immun relat pathway includ phospholipas signal pathway foxo signal pathway metabol xenobiot cytochrom p melanogenesi membran transport carbohydr metabol lipid metabol differ level express sever dem includ l glutam naphthalen succinoylpyridin acyl sn glycerol phosphat l tyrosin involv pathway exhibit immun respons b mori bmnpv infect find valuabl better understand antivir mechan b mori under interact silkworm bmnpv | D012831;D007113;D017924 | T032;T204;T005 |
34,676,594 | therapeut time window compound nmda receptor signal pathway ischem stroke much evid prove excitotox induc excess releas glutam contribut larg damag caus ischemia view key role play nmda receptor mediat excitotox compound nmda receptor signal pathway becom promis type anti stroke candid compound howev limit therapeut time window neuroprotect key factor prevent nmda receptor relat compound show efficaci clinic trial ischem stroke perspect determin therapeut time window kind compound use ensur therapeut effect acceler clinic applic mini review discuss therapeut time window compound nmda receptor signal pathway describ relat influenc factor status clinic studi purpos review look compound wide therapeut time window better clinic applic prospect | D002545;D000083242;D020521 | T047;T046 |
34,676,592 | principl good sleep health principl good sleep health propos facilit improv public health engag import look sleep b offer first line intervent peopl poor sleep mild insomnia symptom goe beyond scope tradit known sleep hygien principl develop author uk nation health servic nhs campaign everi mind matter initi public health england support mental health foundat author serv campaign spokesperson sleep critic ingredi mental wellb principl encourag peopl valu prioritis personalis trust protect sleep intend educ sleep health support evid base self manag sleep altern cognit behaviour therapi cbt guidelin treatment chronic insomnia disord howev may bridg import gap self care practic mani peopl principl would benefit formal research evalu | D015928;D007319 | T048;T047;T184;T061 |
34,676,591 | adult onset immunodefici due anti interferon gamma autoantibodi associ sweet syndrom distinct entiti sweet syndrom ss increas report patient adult onset immunodefici aoid due anti interferon autoantibodi also concomit opportunist infect especi dissemin non tubercul mycobacteri infect dntmi retrospect studi retriev data conduct compar clinic characterist ss without aoid generat predict model examin interact aoid dntmi occurr ss lymphadenopathi pustular lesion leukocytosi signific predictor aoid associ ss adjust risk differ confid interv ci ci ci respect base analysi aggreg cross section data overal direct effect aoid increas preval ss indirect effect aoid occurr ss might also mediat dntmi common opportunist infect addit trend posit addit interact aoid dntmi although test addit interact reveal statist signific result deviat addit isol effect might suggest potenti causal interact aoid dntmi distinct clinic syndrom compris lymphadenopathi pustular lesion leukocytosi patient ss rais awar clinician potenti under aoid | D007153;D016463 | T047 |
34,676,590 | silica encapsul dna tracer measur aerosol distribut dynam real world set aerosol particl play signific role human health environment risk manag global import aerosol relat hazard circul pathogen high level air pollut led surg demand suitabl surrog tracer investig complex dynam airborn particl real world scenario studi propos novel approach use silica particl encapsul dna sped trace agent measur aerosol distribut indoor seri experi portabl setup sped success aerosol recaptur quantifi use quantit polymeras chain reaction qpcr posit depend ventil effect within confin space could shown quantit fashion achiev detect limit ng particl per sampl air conclus sped show promis flexibl cost effect low impact character aerosol dynam wide rang set | D016902;D012822 | T080;T069;T197 |
34,676,589 | masticatori movement food textur older patient eat difficulti investig whether masticatori movement older patient eat difficulti associ oral motor function physic function appropri food textur | D008409;D014070 | T040;T023 |
34,676,588 | lncrna ptprg facilit glycolysi stem properti esophag squamous cell carcinoma cell mir pdk axi esophag squamous cell carcinoma escc signific subtyp esophag cancer featur high occurr long noncod rnas lncrnas prove modul biolog properti cancer cell includ cell prolifer invas migrat apoptosi lncrna protein tyrosin phosphatas receptor type g antisens rna ptprg report play oncogen divers cancer howev detail function ptprg may exert escc unclear | D004938;D000077277;D010744;D062085 | T191;T116;T123;T114;T126 |
34,676,587 | effect short environment enrich earli life advers induc cognit altern adolesc rat earli life experi includ parent care affect cognit perform later life expos earli life matern separ ms increas suscept stress relat psychopatholog previous studi suggest ms could induc learn memori impair sinc enrich environ ee provid opportun explor social interact present studi evalu effect short ee paradigm durat day cognit abil matern separ rat ms minday postnat day pnd adolesc four experiment group control controle ms msee plasma corticosteron cort brain deriv neurotroph factor bdnf level also measur experiment anim also studi induct long term potenti ltp slice hippocamp ca area behavior electrophysiolog assess start pnd ms caus higher basal cort level plasma impair spatial learn memori social interact ltp induct also impair ms rat plasma bdnf level reduc anim ms also induc anxieti like behavior short ee reduc plasma cort level potenti improv locomotor activ anxieti like behavior msee rat revers ms induc impair spatial learn memori social behavior ltp induct plasma bdnf level also enhanc msee rat conclud short ee might consid therapeut strategi promot cognit | D000076783;D008426 | T033;T067 |
34,676,586 | intraop transit time flow measur pump coronari arteri bypass surgeri impact coronari stenosi competit flow combin preoper angiographi find intraop transit time flow measur ttfm may improv patenc coronari arteri bypass graft nevertheless graft flow might impair nativ coronari flow base sever stenos inferior long term outcom studi investig impact left anterior descend arteri lad stenosi competit flow measur left intern mammari arteri lima graft pump coronari arteri bypass graft | D047549;D023921 | T047;T061 |
34,676,585 | perform evalu elecsi sar cov antigen immunoassay diagnost covid one challeng control prevent sever acut respiratori syndrom coronavirus sar cov infect earli diagnost point care sever test base qualit antigen detect develop one elecsi sar cov antigen immunoassay roch diagnost total nasopharyng swab random select aim evalu sensit specif cross reactiv posit negat predict valu ppv npv agreement elecsi sar cov antigen immunoassay use revers transcript polymeras chain reaction rt pcr stat nat coronavirus diseas refer test cross reactiv estim use sampl posit rt pcr respiratori virus influenza virus parainfluenza virus rhinovirus coronavirus oc hku overal sensit elecsi sar cov antigen specif cross reactiv respiratori virus detect elecsi sar cov antigen immunoassay show high sensit sampl cycl threshold valu rang independ symptom ppv npv respect coeffici confid interv show substanti agreement test result suggest elecsi sar cov antigen immunoassay could use altern rt pcr test complement identifi infecti individu reduc sar cov transmiss | D000086382 | T047;T067 |
34,676,584 | cinnamaldehyd eugenol protect lps stimul oxid stress inflamm raw cell macrophag leukocyt play strateg role immun respons associ various diseas due effect inflamm process oxid event current studi evalu anti inflammatori antioxid properti cinnamaldehyd eugenol phyto compound numer bioactiv properti lipopolysaccharid lps induc macrophag cell purpos raw cell incub cinnamaldehyd eugenol stimul lps hr tumor necrosi factor alpha tnf interleukin il il level inflammatori mediat malondialdehyd mda nitric oxid nox level well superoxid dismutas sod catalas cat activ oxid status marker determin cell cultur cinnamaldehyd eugenol pre treatment decreas tnf il il level compar lps group concentr furthermor pre treatment increas sod activ decreas mda nox level well cat activ differ concentr result demonstr phyto compound potenti treatment various diseas protect agent chronic inflamm oxid stress practic applic chronic inflamm oxid stress complic play detriment role pathophysiolog mani diseas altern treatment method investig prevent cinnamaldehyd eugenol phyto compound high bioactiv obtain food spice studi protect effect cinnamaldehyd eugenol lipopolysaccharid induc oxid stress inflamm macrophag cell investig accord obtain result cinnamaldehyd eugenol pre treatment decreas inflamm also reduc oxid stress cinnamaldehyd eugenol may better natur altern protect agent chronic inflamm oxid stress relat diseas | D005054;D008070 | T121;T109 |
34,676,582 | cours covid associ tuberculin skin test diamet retrospect studi pathogenesi coronavirus diseas covid still fulli understood sever acut respiratori syndrom coronavirus sar cov similar pathogenet pathway mycobacterium tuberculosi report may relationship bacill calmett gurin bcg vaccin rate covid sever studi investig relationship tuberculin skin test tst indur diamet clinic cours covid adult patient underw tst patient sar cov infect confirm rt pcr analysi respiratori tract sampl includ studi relationship covid clinic sever tst posit indur size clinic paramet analyz patient tst result negat patient posit patient covid sever mild patient moder patient sever seven patient tst posit patient mild diseas patient mild diseas signific higher tst posit rate p larger indur diamet p area receiv oper characterist roc curv tst indur size differenti mild moder sever diseas p maximum youden j index valu indur diamet mm sensit specif covid patient posit tst show signific higher rate mild diseas negat tst tst posit favor associ cours covid | D000086382;D009169 | T007;T047;T067 |
34,676,581 | virtual screen function food dissect role modul gene function support post covid complic covid becom focal point sinc outbreak coronavirus diseas mani drug test use treat coronavirus infect differ kind vaccin also introduc prevent measur altern therapeut well incorpor health guidelin countri research aim look under mechan function food may improv long term post covid cardiovascular diabet respiratori complic bioactiv compound potenti nine function food post covid complic investig comput approach total bioactiv compound food search via extens literatur review three high associ target name troponin interact kinas tnnik dipeptidyl peptidas dpp transform growth factor beta tgf select cardiovascular diabet respiratori disord respect covid infect best dock compound analyz network pharmacolog tool explor interact complic relat gene mapk hspaa cardiovascular pparg tnf alpha diabet akt respiratori disord seventi one suggest compound one hundr thirti nine dock compound network pharmacolog recommend gene ontolog go item kyoto encyclopedia gene genom signal pathway prefer akt signal pathway mapk signal pathway ace receptor signal pathway insulin signal pathway ppar signal pathway among chosen function food black cumin fenugreek garlic ginger turmer bitter melon indian pennywort found modul action result demonstr aforesaid function food attenu role manag post covid complic practic applic function food approach greater interest due medicin use gastronom pleasur nine function food resourc use research tradit ethnopharmacolog use direct role modul gene involv manag post covid complic inadequ studi report therefor food type use research may priorit use function food amelior major post covid complic appropri scienc | D000086382;D004365 | T123;T047;T121;T067 |
34,676,580 | simultan detect differenti mycobacterium lepra mycobacterium lepromatosi use novel polymeras chain reaction primer develop polymeras chain reaction base method detect distinguish mycobacterium lepra mycobacterium lepromatosi use singl set primer base bp differ amplicon size rpot gene method also help detect case co infect singl experi | D007918;D009161 | T007;T047 |
34,676,579 | use real world evid translat pharmacolog research real world evid rwe refer observ data gather outsid formal random control trial real life situat market drug clinic trial gold standard demonstr efficaci toler medicin product generaliz result actual use real life limit bias induc natur clinic trial inde patient includ trial may differ actual user concomit diseas treatment factor exclud trial clinic research pharmaceut industri henc becom increas interest expand integr rwe clinic research capit exponenti growth access data electron health record claim databas electron devic softwar mobil applic registri embed clinic practic social media meanwhil applic rwe may also use drug discoveri repurpos clinic develop post market studi aim review provid opinion regard use rwe translat research includ non clinic clinic pharmacolog research differ step drug develop use | D057286;D057170 | T062;T170;T073 |
34,676,578 | covid yorkshir rehabilit scale c yrs applic psychometr analysi post covid syndrom cohort understand natur preval post coronavirus diseas covid syndrom pcs increas measur impact covid could provid valuabl insight patient percept clinic trial epidemiolog studi well routin clinic practic evalu clinic use psychometr properti covid yorkshir rehabilit scale c yrs patient pcs prospect observ studi consecut patient attend post covid rehabilit clinic conduct c yrs use record patient symptom function disabl global health question use measur overal impact pcs health classic psychometr method data qualiti scale assumpt target reliabl valid use assess c yrs total group miss data low scale target assumpt satisfi intern consist high cronbach relationship overal percept health patient report symptom function disabl demonstr good concord first studi examin psychometr properti outcom measur patient pcs sampl patient c yrs clinic use satisfi standard psychometr criteria provid preliminari evid suitabl measur pcs | D000086382 | T047;T067 |
34,676,577 | cost effect efficaci fluorid varnish cari prevent south african children cluster random control communiti trial cluster random control communiti trial aim assess efficaci cost fluorid varnish fv applic cari prevent high risk popul south africa | D003731;D005460 | T033;T047;T122 |
34,676,575 | imprint canin igf h genom imprint occur therian mammal phenomenon wherebi two allel gene differenti express base sex parent allel inherit allel differ express consequ differ epigenet modif establish sperm oocyt gametogenesi transmit fertil offspr small minor gene regul way import biolog function aberr regul imprint gene contribut diseas aetiolog human anim factor drive evolut imprint gene also consider interest gene appear forego benefit diploidi broaden phylogenet analysi genom imprint began studi imprint gene domest dog cani familiari report show canin igf h imprint parent origin depend monoallel express pattern neonat umbil cord identifi putat imprint control region associ gene provid evid differenti methyl region somat tissu umbil cord hypermethyl male germlin cani familiari fast becom high inform system elucid diseas process evolut studi imprint gene speci may help understand gene contribut generat morpholog behavior divers | D019175;D018392 | T044;T045 |
34,676,574 | evalu potenti global impact ny mutat sar cov posit patient rapid reliabl detect sever acut respiratori syndrom coronavirus mutat signific control contagion spread rate virus aim evalu ny mutat rate random chosen posit patient polymeras chain reaction pcr evalu analysi data retrospect approach case mutat term public health contribut literatur global pandem affect societi public health author take necessari precaut evalu current situat ny mutat detect patient posit covid pcr test result posit sampl examin base carboxi fluorescein fam channel revers transcript pcr rt pcr quantit cycl cq valu low cq medium cq high cq group studi case detect mutat suspect found mutat age case mutat rang year mean age n case mutat male n femal rt pcr cq result examin seen vari averag | D000086382;D000086402;D064370 | T116;T047;T123;T005;T067 |
34,676,573 | open surgeri utero repair spina bifida microneurosurgeri versus standard techniqu systemat review prenat myelomeningocel mmc repair shown improv neurolog outcom suggest decreas hysterotomi diamet surgeri improv perinat outcom without alter neurolog outcom object studi describ compar main matern fetal outcom fetus undergo open surgeri mmc repair differ modif standard classic mini hysterotomi microneurosurgeri | D005865 | T032 |
34,676,572 | assess semin cystatin c level infertil men varicocel preliminari studi varicocel rais contributor male infertil support improv sperm paramet varicocelectomi cystatin c cys c link sever cellular chang common male infertil case associ varicocel apoptosi autophagi preliminari studi aim assess semin level cys c infertil oligoasthenoteratozoosperm oat men associ varicocel shown spermat vein vasodil activ death pathway overal men investig divid two equival group infertil oat men varicocel underw varicocelectomi healthi fertil men control group men subject histori take clinic examin semen analysi assess semin cys c pre month post varicocelectomi result show signific increas semin cys c infertil oat men varicocel fertil control ngml versus ngml p semin cys c signific decreas post oper pre oper level versus ngml p result show potenti role cys c varicocel induc infertil | D007248;D014646 | T033;T047;T184 |
34,676,571 | burn primari testicular tumour retroperiton lymph node biopsi mandatori prior initi chemotherapi report three case review literatur term burn tumour testi describ spontan complet regress testicular tumour present stage metastasi report three case burn testicular tumour illustr clinic radiolog histopatholog featur discuss hypothesi efficaci earli adjuv chemotherapi without previous retroperiton lymph node biopsi subsequ radic orchiectomi pathohistolog report reveal testicular hypotrophi microcalcif clear visibl germ cell tumour within specimen addit follow surgeri patient receiv standard cisplatin etoposid bleomycin chemotherapi protocol two three case show complet respons one examine reveal partial respons receiv salvag chemotherapi remain remiss phase last follow studi illustr valu earli administr adjuv chemotherapi patient burn testicular tumour offer possibl omit diagnost retroperiton lymph node biopsi consid low threshold testicular malign clear utmost import rare patient treat time manner without adjunct procedur lymph node biopsi lead addit morbid | D009373;D013736 | T191 |
34,676,570 | glycyrrhiza glabra alcohol root extract amelior hyperglycemia hyperlipidemia glycat induc free iron mediat oxid reaction hyperglycemia associ oxid stress lead various pathophysiolog complic diabet mellitus effect glycyrrhiza glabra g glabra root extract streptozotocin stz induc diabet chang associ free iron mediat oxid reaction investig anim divid five group group control nc receiv buffer group stz induc dc group control treat g glabra root extract nt mgkg bw daili month group diabet treat extract mgkg bw daili month group diabet treat glibenclamid dtg mgkg bw month stz induc hyperglycemia abnorm intraperiton glucos toler test ipgtt increas hba c decreas plasma insulin level ii hyperlipidemia iii lower antioxid enzym activ iv diminish rbc membran fluiditi v enhanc hemoglobin glycat induc iron releas associ free radic reaction treatment extract result signific revers hyperglycemia dc mgdl vs dt mgdl p hba c dc vs dt vs dt p insulin dc vs dt gml p free iron dc vs dt gmgm hb p tbar dc h vs dc h mmolesh p carbonyl dc vs dt mmolesg hb p level cell countpancreat islet dc vs dt p thus g glabra extract quit effect hyperglycemia associ free iron mediat oxid stress practic applic chronic use oral hypoglycem synthet drug may produc side effect drug resist recent various plant extract research explor antihyperglycem potenti effect alcohol powder root extract stz induc diabet chang associ oxid stress includ hemoglobin induc free iron mediat oxid reaction examin stz induc diabet chang hemoglobin glycat induc free iron mediat oxid reaction allevi wistar rat month treatment extract also report previous glycyrrhizin bioactiv constitu glycyrrhiza glabra root inhibit peroxidas esteras activ hemoglobin hemoglobin mediat oxid damag without affect oxygen bind capac protein preclin work substanti potenti therapeut use g glabra whole root extract treatment diabet mellitus | D003921;D006035;D006943;D006949 | T033;T047;T050;T002 |
34,676,569 | diagnosi lumbar transvers process fractur orthoped clinic use sonographi sonographi convent use diagnos fractur identifi cortic discontinu bone howev use diagnos lumbar transvers process fractur ltpfs remain unknown seri describ static stress sonographi find manual applic compress stress later lumbar vertebra patient ltpfs featur ltpfs static sonographi includ cortic discontinu hematoma step deform focal reverber echo ltpfs confirm stress sonographi thus stress sonographi consid detect ltpfs least one static sonograph fractur sign | D050723;D008159 | T023;T037 |
34,676,568 | matern infant bond opioid expos dyad rodger evolutionari concept analysi concept analysi aim offer insight opioid exposur affect qualiti construct matern infant bond | D008427;D009357 | T058;T047 |
34,676,566 | effect daucus carota extract pc pnta prostat cell acetylcholinesteras glutathion transferas glycosidas vitro silico studi daucus carota l ssp major dcm plant wide use tradit medicin treat type cancer various diseas therefor evalu biolog activ plant defin effect prostat cancer pca alzheim diseas ad oxid diabet mellitus dm well identifi phenol composit determin anti cancer properti plant extract treat pca cell extract concentr rang mgml signific result obtain pc cell compar normal pnta prostat epitheli cell result precis measur millimolar level observ plant extract show effect inhibit ic glutathion transferas gst mm acetyl cholinesteras ach mm gli mm enzym compar standard inhibitor antioxid activ dcm methanol extract determin via two well known vitro techniqu extract show antioxid activ dpph abt lc esi msms use determin phenol compound methanol extract dcm chlorogen acid gg shikim acid gg coumarin gg character major phenol compound addit interact chlorogen acid chrysin coumarin shikim acid use three enzym calcul use molecular dock simul practic applic plant natur phenol compound protect effect anti inflammatori antioxid anticarcinogen enzym inhibitori therefor import place food pharmaceut industri present studi aim reveal enzym inhibitori antioxid anticarcinogen properti daucus carota ssp major dcm plant extract signific result obtain pc cell compar normal pnta prostat epitheli cell dcm extract demonstr consider antioxid activ inhibitori potenti use metabol enzym biolog effect thought relationship rich chemic composit | D000110;D018552 | T116;T002;T126;T168 |
34,676,565 | link violent video game cyberaggress among colleg student cross section studi explor relationship exposur violent video game colleg student cyberaggress behavior intern mechan cross section survey carri sampl colleg student complet violent video game list questionnair vvlq adolesc onlin aggress behavior scale aoab belief support violenc scale bsvs trait anger scale tas result show exposur violent video game posit associ colleg student cyberaggress behavior trait anger moder posit relationship exposur violent video game colleg student cyberaggress behavior trait anger moder posit relationship exposur violent video game colleg student attitud toward violenc attitud toward violenc act partial mediat posit relationship exposur violent video game colleg student cyberaggress behavior attitud toward violenc trait anger play mediat moder role posit relationship exposur violent video game colleg student aggress behavior | D000374;D018910 | T073;T055 |
34,676,564 | purif character se enrich grifola frondosa glycoprotein evalu amelior effect induc immun toxic selenium se enrich glycoprotein research highlight role se glycoprotein immunoregul arsenic toxic potenti toxic immun function consequ human health sever report suggest se could reduc toxic heavi metal moreov nutrient food appli reliev induc toxic henc glycoprotein isol purifi se enrich grifola frondosa preliminari characterist well amelior effect mechan induc immun toxic evalu | D001151;D048691;D012643 | T121;T123;T004;T131;T196 |
34,676,563 | versatil genet toolbox prevotella copri enabl studi polysaccharid util system prevotella copri preval inhabit human gut associ plant rich diet consumpt divers health state under genet basi associ remain enigmat due lack genet tool develop novel versatil genet toolbox rapid effici genet insert allel exchang applic p copri strain multipl clade enabl genet platform systemat investig specif polysaccharid util loci pul identifi four high conserv pul util arabinan pectic galactan arabinoxylan inulin respect genet function analysi arabinan util system illustr p copri evolv two distinct type arabinan process pul pul ara type ii pul ara signific enrich individu consum vegan diet compar diet summari genet toolbox enabl function genet studi p copri futur | D014676;D000069196;D056426;D016680 | T007;T001;T028;T061;T033 |
34,676,560 | vf cpvt mutat yield distinct ryr channel popul differ respons cytosol ca mg catecholaminerg polymorph ventricular tachycardia type cpvt lethal genet diseas caus arrhythmia sudden cardiac death children young adult link mutat cardiac ryanodin receptor ryr effect cpvt mutat ryr ion channel function often investig use purifi recombin ryr channel homozyg mutat howev cpvt patient heterozyg diseas approach reveal true chang ryr function across entir ryr popul channel heart therefor investig nativ cardiac ryr singl channel abnorm mice heterozyg cpvt mutat vf ryr appli molecular model techniqu investig possibl structur chang could initi alter function observ increas sensit cardiac vf ryr channel activ inactiv level cytosol ca plus attenu mg inhibit mark chang sever abnorm uniform across channel give rise multipl sub popul differ function characterist exampl vf ryr channel exhibit reduc mg inhibit actual activ mg use homolog model discov v situat hing two region ryr helic domain hd model propos detriment function chang ryr aris mutat critic site reduc angl region result demonstr necess characteris total heterozyg popul cpvt mutat channel order understand cpvt phenotyp patient key point ryr mutat caus type catecholaminerg polymorph ventricular tachycardia cpvt lethal autosom domin arrhythm diseas howev chang ryr ion channel function result mani differ patient mutat rare investig detail often recombin ryr homozyg mutat studi cpvt heterozyg diseas tetramer ryr channel express heart contain vari number mutat monom investig rang ryr singl channel abnorm found heart mice heterozyg cpvt mutat vf ryr specif alter ligand regul vf ryr observ multipl sub popul channel exhibit vari degre abnorm particular increas sensit activ inactiv cytosol ca reduc sensit mg inhibit evid result provid mechanist insight chang ryr gate destabilis sarcoplasm reticulum ca releas caus life threaten arrhythmia vf cpvt patient | D019837;D017180 | T192;T116;T047;T046 |
34,676,558 | short term function chang hospit discharg covid teleconsult refer servic northeast brazil cross section studi coronavirus infect diseas covid associ physic function emot declin patient covid hospit intern object evalu main function chang hospit discharg covid teleconsult cross section studi carri april juli peak period new case hospit admiss death covid recif brazil includ patient n year posit covid rt pcr test hospit day function aspect muscl pain short breath cough weight loss kg weaknessfatigu daili live activ balanc walk lie sensit anxietysad alter memori understand assess besid impact hospit admiss daili activ qualiti inform obtain teleconsult quantifi mean age year hospit mean intern day main find studi show four predomin function alter weight loss greater kg muscl fatigueweak musclejoint pain anxietysad function analyz patient report dysfunct least three alter evalu sever short term physic function emot chang adult hospit discharg | D000086382;D019114 | T047;T060;T067 |
34,676,557 | copper induc oxid stress apoptosi hippocamp neuron via pcrebbdnf nrfho nqo pathway disord copper metabol suggest occur sever neurolog condit includ alzheim diseas parkinson diseas howev under mechan still unclear might link copper induc hippocamp neuron apoptosi decreas neuron viabil vitro experi show copper exposur induc oxid stress promot apoptosi ht murin hippocamp neuron cell mechanist found copper one hand prevent phosphoryl camp respons element bind protein creb decreas express downstream target protein brain deriv neurotroph factor bdnf decreas mitochondri membran potenti bcl bax ratio hand copper induc reactiv oxygen speci ros promot lipid peroxid reduc antioxid enzym activ gsh px copper induc oxid damag decreas phosphoryl creb decreas express bcl enhanc express bax acceler dissoci keap nrf complex promot nuclear transloc nrf stimul express antioxid molecul ho nqo conclus found copper inhibit pcrebbdnf signal pathway prevent creb phosphoryl found oxid damag inhibit neuroprotect signal pathway induc apoptosi activ antioxid protect signal nrfho nqo signal pathway | D019208;D051267 | T116;T123 |
34,676,555 | cascad deep learn base auto segment head neck cancer patient organ risk weight magnet reson imag investig multipl deep learn method autom segment auto segment parotid gland submandibular gland level ii level iii lymph node magnet reson imag mri outlin radiosensit organ imag use assist radiat therapi radiotherapi patient head neck cancer hnc time consum task variabl observ may direct impact patient treatment outcom auto segment comput tomographi imag shown result signific time reduct consist outlin organ risk | D000077321;D006258 | T191;T066 |
34,676,552 | self direct learn readi learn style among omani nurs student implic onlin learn covid pandem emerg covid pandem compel mani academ institut resort distanc learn onlin educ requir higher degre student self direct motiv learn studi explor self direct learn sdl readi among nurs student oman learn style ls associ demograph variabl ls sdl | D000086382;D020375;D013338 | T097;T065;T047;T067 |
34,676,551 | lignin organ free radic maiz zea may l seed respons aflatoxin b contamin optic epr spectroscop studi aflatoxin b afb danger mycotoxin contamin cereal seed natur stress lignin format link accumul reactiv oxygen speci caus chang redox status format stabl organ radic constitut first layer defens relationship afb chang lignin organ free radic seed known part seed target use optic electron paramagnet reson spectroscopi investig afb induc chang lignin organ free radic seed whether inner outer seed fraction differ respons increas afb | D016604;D003313 | T002;T109;T168;T131;T196 |
34,676,550 | bogert effect factor evolut behavior one major architect evolut behavior modifi interact environ organ influenc natur select amplifi case dampen other one earliest issu evolut charl bogert propos regulatori behavior name thermoregul shield organ select limit physiolog evolut trace histori surround origin concept known bogert effect behavior inertia implic physiolog evolutionari research throughout th centuri key follow studi earli st centuri galvan renew interest bogert classic idea establish focus slowdown rate evolut respons regulatori behavior illustr recent progress bogert effect evolutionari research discuss ecolog variabl predict whether strong phenomenon unfold base discoveri provid hypothes bogert effect across sever scale pattern trait evolut within among group speci spatial effect phenomenon import speciat also discuss inher link behavior inertia behavior drive empir case studi link phenomena modern compar approach help put macroevolutionari implic behavior buffer test describ progress date area ripe futur investig despit mani advanc bridg microevolutionari process macroevolutionari pattern remain persist gap understand bogert effect leav wide open mani avenu deeper explor | D005075;D001833 | T040;T045 |
34,676,548 | advantag listen academ content second languag may outweigh disadvantag cognit load theori approach frequent implicit assum advantag languag acquisit learn content second languag exceed disadvantag reduc content acquisit | D007802;D007804 | T171;T041 |
34,676,547 | comparison physicochem emulsifi properti commerci pea protein powder increas trend food industri util plant base protein pea protein pp one protein promis altern emulsifi howev signific function gap laboratori commerci produc pp limit usag physicochem emulsif properti five commerci pp powder character better understand function gap | D000078724 | T116 |
34,676,546 | regul cancer progress circrna function protein circular rnas circrna close back splice product precursor mrna eukaryot compar linear mrnas circrna special structur stabl express larg number studi provid differ regulatori mechan circrna tumor challeng exist understand control circrna sequenc overlap linear mrna survey recent progress regard regul circrna biogenesi rna bind protein one vital function protein furthermor substanti circrna exert compel biolog role act protein spong translat regul posttransl modif protein review help explor type function protein interact circrna cancer reveal unknown mechan circrna regul | D009369;D000079962 | T191;T114 |
34,676,545 | hydrogen peroxid phosphoinositid metabolit synergist regul cation current influenc neuroendocrin cell burst various neuron includ neuroendocrin cell non select cation channel elicit plateau potenti persist fire reproduct marin snail aplysia californica initi neuroendocrin bag cell neuron undergo afterdischarg prolong period enhanc excit spike egg lay hormon releas blood afterdischarg associ product hydrogen peroxid h activ phospholipas c plc hydrolys phosphatidylinositol bisphosph diacylglycerol dag inositol trisphosph ip previous demonstr h gate voltag depend cation current evok spike bag cell neuron present studi test dag ip impact h induc current excit whole cell voltag clamp cultur bag cell neuron bath applic oleoyl acetyl sn glycerol oag dag analogu enhanc h induc current amplifi inclus ip pipett similar outcom produc plc activ n trifluoromethylphenyl trimethylbenzenesulfonamid current clamp oag oag plus ip elev frequenc h induc burst pkc also trigger afterdischarg pkc stimul phorbol myrist acet caus voltag depend inward current revers potenti similar h induc current furthermor pkc activ follow h reduc onset latenc increas durat action potenti fire final inhibit nicotinamid adenin dinucleotid phosphat oxidas benzyl benzoxazolyl thio triazolo pyrimidin diminish evok burst isol bag cell neuron cluster result suggest reactiv oxygen speci phosphoinostid metabolit may synerg contribut reproduct behaviour promot neuroendocrin cell fire key point aplysia bag cell neuron secret reproduct hormon lengthi burst action potenti known afterdischarg afterdischarg phospholipas c plc hydrolys phosphatidylinositol bisphosph diacylglycerol dag inositol trisphosph ip subsequ activ protein kinas c pkc lead h product h evok voltag depend inward current action potenti fire dag analogu oleoyl acetyl sn glycerol oag ip enhanc h induc current mimick plc activ n trifluoromethylphenyl trimethylbenzenesulfonamid frequenc h evok afterdischarg like burst augment oag oag plus ip stimul pkc phorbol myrist acet shorten latenc increas durat h induc burst nicotinamid adenin dinucleotid phosphat oxidas inhibitor benzyl benzoxazolyl thio triazolo pyrimidin attenu burst fire bag cell neuron cluster | D055099 | T025 |
34,676,544 | monitor larg thrombus straddl patent foramen oval use cardiac point care ultrasound use cardiac pocus captur thrombus straddl pfo determin peripher venous sourc complet dissolut larg trap thrombus remiss sign pulmonari embol monitor time great valu subsequ treatment decis make | D054092;D011655;D013927 | T047;T019;T046 |
34,676,543 | genet characteris childhood b acut lymphoblast leukaemia uk patient fluoresc situ hybridis multiplex ligat depend probe amplif next generat sequenc technolog provid excel strategi screen newli defin genet abnorm prognost therapeut signific patient b acut lymphoblast leukaemia wide avail use dual screen approach incorpor fluoresc situ hybridis fish multiplex ligat depend probe amplif mlpa establish frequenc long term outcom repres cohort specif subgroup b recruit childhood trial ukal focuss abnorm known prognost signific includ abl class fusion erg delet surrog marker dux rearrang abl class fusion account b associ high level minim residu diseas mrd mrd high relaps rate follow treatment without tyrosin kinas inhibitor tki confirm import prospect screen view incorpor tki therapi patient delet erg b year event free surviv valid previous report excel outcom rearrang znf mefd nutm observ low frequenc estim approxim one third b patient reliabl classifi one known genet subgroup use dual screen method approach rapid accur readili incorpor routin test | D014408;D020022;D017404 | T032;T063;T123 |
34,676,542 | fenfluramin signific reduc day day seizur burden increas number seizur free day time seizur patient dravet syndrom time event analysi number unpredict sever seizur experienc patient dravet syndrom ds negat impact qualiti life qol patient caregiv famili metric need assess whether patient residu seizur move meaning toward seizur freedom treatment new antiseizur medic | D004831;D011788 | T047;T078 |
34,676,540 | breadstick fortif red grape pomac effect nutrit technolog sensori properti grape pomac gp wine make product rich dietari fiber df total phenol compound tpc potenti function ingredi fortif bake good | D005433;D027843 | T129;T002;T116;T168 |
34,676,539 | keton incorpor extend emiss properti xanthen scaffold beyond nm imag shortwav infrar region swir nm potenti enabl deep tissu imag high resolut critic develop method identif low molecular weight biolog compat fluoresc probe emit beyond nm exchang bridg oxygen atom xanthen scaffold c posit electron withdraw group shown lead signific redshift absorb emiss guid quantum chemistri comput model studi investig instal keton bridg c posit simpl modif extend absorb maxima nm emiss beyond nm albeit reduc photon output overal studi demonstr broad appli xanthen dye extend swir rang | D007659;D014966 | T109 |
34,676,538 | digest proteinas marin fish process wast south west atlant ocean partial character comparison fish process generat plenti wast direct discard open air dump water sourc treat way urban solid wast caus serious pollut problem wast repres signific sourc high valu bioproduct potenti applic differ industri process product feed fertil biodiesel bioga deterg addit cosmet object studi character compar specif activ differ ph valu temperatur condit acid alkalin proteinas viscera yield follow fish speci argentin hake merluccius hubbsi brazilian flathead percophi brasiliensi brazilian codl urophyci brasiliensi strip weakfish cynoscion guatucupa individu fish coast mar del plata argentina commerci fleet viscera immedi extract kept ice use stomach proteinas four speci highest activ ph stabil rang ph optimum ph intestin enzym c guatucupa hubbsi p brasiliensi intestin enzym u brasiliensi alkalin proteinas speci high stabl rang optimum temperatur stomach proteinas four speci studi c stabil c min optimum temperatur intestin enzym test speci c high stabil c min alkalin proteinas speci acid proteinas c guatucupa inact c min residu activ lower c pre incub stomach enzym mhubbsi p brasiliensi u brasiliensi min respect digest proteinas recov studi could appropri technolog usag reduc manufactur cost obtain revenu fisheri wast contribut reduct environment pollut | D048388;D010447 | T116;T121;T168;T013;T126 |
34,676,536 | mechanotransduct meniscus fibrochondrocyt caveola meniscus fibrochondrocyt mfcs import cell popul respons regul biomechan properti knee meniscus despit signific much known includ sens respond mechan stimuli due mechan natur knee joint therefor paramount understand meniscus mechanotransduct mechan elucid review summar current knowledg mechanotransduct mfcs highlight relev caveola lieu recent discoveri addit discuss import futur studi area help advanc field meniscus research | D040542;D000072600 | T044;T023 |
34,676,534 | beta adrenerg receptor emerg target combat obes induc lean treatment obes repurpos novel drug expand research field one approach target beta adrenerg receptor regul metabol phenotyp adipos skelet muscl tissu sever observ support role beta adrenerg receptor obes specif human beta adrenerg receptor polymorph associ bodi composit obes glnglu polymorph associ obes argg polymorph associ lean mass men develop obes specif popul individu obes also lower abund beta adrenerg receptor adipos tissu less sensit catecholamin addit studi livestock rodent demonstr select beta agonist induc call repartit effect character muscl accret reduc fat deposit human beta agonist dose depend increas rest metabol rate like observ mammal week treatment beta agonist increas muscl mass reduc fat mass young healthi individu beta agonist also exert benefici effect bodi composit use concomit train act addit increas muscl strength mass period resist train thus beta adrenerg receptor seem like attract target develop anti obes drug howev futur studi need verifi long term efficaci safeti beta agonist individu obes particular comorbid | D055070;D013851 | T033;T061 |
34,676,533 | vagus nerv stimul activ nucleus solitari tract neuron via supramedullari pathway vagus nerv stimul vns treat patient drug resist epilepsi depress heart failur mechan respons uncertain mild stimulus intens use chronic vns suggest activ myelin primari viscer affer project nucleus solitari tract nts monitor activ second higher order nts neuron respons peripher vagal activ use therapeut vns criteria bipolar stimul electrod activ left cervic vagus nerv stereotax place singl tungsten electrod record unit activ left caudomedi nts chloralos anaesthet rat high intens singl electr stimuli establish vagal affer conduct veloc myelin type unmyelin c type well synapt order second vs higher order use pair electr stimuli input singl nts neuron vns treatment appli mid collicular knife cut kc divid brainstem supramedullari region determin contribut nts activ chief find indic kc reduc basal spontan activ second order nts neuron receiv myelin vagal input neuron acut vns increas activ similar control kc anim interest kc interrupt vns activ higher order nts neuron second order nts neuron receiv unmyelin vagal input indic supramedullari descend project nts need amplifi peripher neuron signal vns present studi begin defin pathway activ vns help better identifi central nervous system contribut therapeut benefit vns therapi key point vagus nerv stimul routin use clinic treat epilepsi depress despit uncertainti treatment work studi connect nucleus solitari tract nts higher brain region sever learn contribut activ neuron stimul sever brain connect reduc baselin activ well reduc stimul induc activ nts neuron receiv myelin vagal input higher brain region play signific role maintain normal activ nts indirect mechan enhanc nts neuron activ vagus nerv stimul | D055536 | T061 |
34,676,532 | anticoagul acut ischaem stroke stroke third lead caus earli death worldwid ischaem stroke caus blood clot block arteri brain patient outcom might improv offer anticoagul reduc risk develop new blood clot increas risk bleed updat cochran review first publish updat | D002545;D000083242;D020521 | T047;T046 |
34,676,531 | fifteen year enzym therapi pomp diseas quinc ao de la terapia enzimtica en la enfermedad de pomp | D056947 | T061 |
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